miRTarBase - #MIRT463178


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pre-miRNA Information
pre-miRNA hsa-mir-451b   
Genomic Coordinates chr17: 28861371 - 28861438
Description Homo sapiens miR-451b stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-451b
Sequence 7| UAGCAAGAGAACCAUUACCAUU |28
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 2 17 + 28861378 16594986, 27587585 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs761024330 13 dbSNP
rs1173019348 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZNF281   
Synonyms ZBP-99, ZNP-99
Description zinc finger protein 281
Transcript NM_012482   
Expression
Putative miRNA Targets on ZNF281
3'UTR of ZNF281
(miRNA target sites are highlighted)		 
>ZNF281|NM_012482|3'UTR
   1 GGTCCCAAAAGTGGCCAGGCTGGAGGTCTTCTAATGTAATTTTGTTTTATTTTGAGAACACTGCCATTGGAATGTTTCTA
  81 CACGATCCTATTAAGAATAATGTGATGCCCTTTCAATGCAACTTTTCATATTTAGTTTATTTTGTTAGCGTGATTTTAGC
 161 TCTGTTTGTATTATGATTTTTAATCAAAATCAATAGATTAAAAATAGTTTGACATTCAAAGTGACAATGTTTAGCAATCA
 241 AATTTACATGTATAGATCGTCAGGGAATAGCCCAAATGTTTTAAACGCAAAAAAAAAGACAAAAAAAAACCAAAAAAAAA
 321 AAACCTACAAAAAAAACTTTGTTGCTAGGATTAAGGTTATTCTAATTGCTTTACTCTCAGGAAAGTGTAATAACGCATGG
 401 GAATTCTGTACGTTATCACTGTAATGGAATATCCAATTTACAGATAGTATGATATACATTTCATCATTTAAGTAAGGGAT
 481 CGAAAACATTTCAAATTGCTCTATCTGGGCTGATAGACATTTCGTCATTTAAGTAAGGGATCGAAGACATTTCAAATTGC
 561 TATCTCCATCTGGGCTGATCCAAAATTCTGAGATTGTTGGCTACCTATATTTTGTTGCAGCTTTTAAATGTACTCTGAAC
 641 TTCCAAACCACATTCATTCCAGCCTGGTAGAACAAATATTCTTGGATCTTTGATCAAAGCCTGGAATGATAGCTTTAATA
 721 AAAGAAGGAAAAAAAAAAAGCACCCTCTCTTGATCTCAACTGTAACAAGGCTGTAATTCCATCAAGCGATTCTACTGACA
 801 TCTAGTACAGTGTTGAAGCCCAAGTGGTTGGCTGGTTCCAGTATTAGAACTCAAGTTGAAATTATATGATTAACTGAAAT
 881 TTGGGGCATGCATTATTTATTATACATGGCCTACAACGGTTCTGTCTGCGCTGTTACGTATTACCTACACTTCTGGGTTT
 961 TTTTGTTCTTGTTCTCAGCCTCTCTTTAAGAGTTCTTGGGCCTTCCTTTTCCCTCTTTCTATTTTAACAGTTTTAATTTT
1041 AGAACCATTTACATTCCAGTAGGTAATTCACTATGCGCTTTATATGCCTTAGGGCATCCAAATAAAAAACAATAGGGTAA
1121 ACATCCCCAAAACCCACCTTTAAAAAAAAAAAAACCCATACAGATTTCCATATGTAATAAAACCCCGTGTTCTTGGATAG
1201 ATATTAATAAGGTTGTAATTCCAACTGGTGACATAACTCCTGTGAGGGATAAGAATGTGTCTGCTTATAGTAATAACATC
1281 AGAACCTCTTTGTGAAATTGCGGCCTTTAATGTACATTTTAATGAAAGGGTGCATTAGTATTGTACAGGGGTCTTGTAAA
1361 GTCATCAAAACTTGCTATGAACTCTAATTGCCATTTGAAGCTACTGATTGGCAGTGGCTCTACTCTAAAACTGCTTTTTA
1441 GCAATTGTATTTTTTTCCTGATTATATTTTTTAATGTACTTTGATGTTTATGCTGATGAGTTTTTTATGTACTTTTGGTG
1521 ATGTTTCAGTCTTATGTACTCTTCTGACGTCAGAAAAGTACCACTGGTTGTTTGCAGTCTTATTGTGTAATCAGCCTACC
1601 GCAGGCTTCCATGTATAATAAAGTAATTAATATTGTGCAAGTGTAAAACACTTCTGTTATAAAAGCAGTGTTTGGAAAAT
1681 AAGAAATATTAAAAATGGTTACAAAGTATTAGTTAATTTCCTTTTCCCACTTTCCTCCCTTTAGCTTTAGCAGCTAAAGG
1761 GTCACCAACTTGTCATTGCAAGATTCTTAGAAAATGTACTTAATCTTAAATACGCTGAGTACTAAAAAGTGTTTATTTCT
1841 TATTTCAGTAAGTGCGGTAAGTTCTATTGAGTACAGAGTACAAGCTGTAATCAAAGGATGGAGAGGACCTTTACCACTGT
1921 ATCTCTTAAGCTGTATGATTTTTCTCCAGTTTGTTTTATACAGGTTTTGAATTTCTTTAACTTTTATTGTGTGTACTGAA
2001 TACTGCATATGTATTATTCTGATTGTTTGCTCTAGTTTACTACCAATAAAAGTCCTGTTAATCACAAGATTAAAAAAAAA
2081 AAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uuaCCAUUACCAAGAGAACGAu 5'
             |||  |  | :|||||:| 
Target 5' ctgGGTTTTTTTGTTCTTGTTc 3'
 953 - 974 135.00 -11.06
2 
miRNA  3' uuaccAUUACCAAGAGAACGAu 5'
               |||| ||  |:|||:| 
Target 5' tcttcTAAT-GTAATTTTGTTt 3'
 27 - 47 124.00 -5.50
3 
miRNA  3' uuaccAUUACCAAGAGAACGAu 5'
               ||:|  || |:|||:| 
Target 5' atattTAGT--TTATTTTGTTa 3'
 128 - 147 121.00 -6.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30458048 20 COSMIC
COSN30162069 60 COSMIC
COSN31560073 64 COSMIC
COSN30512994 67 COSMIC
COSN30173795 83 COSMIC
COSN30175395 87 COSMIC
COSN30495969 107 COSMIC
COSN30419820 185 COSMIC
COSN6018799 197 COSMIC
COSN31528508 212 COSMIC
COSN31522289 222 COSMIC
COSN31609565 258 COSMIC
COSN31553423 286 COSMIC
COSN30539868 288 COSMIC
COSN29007923 311 COSMIC
COSN15662061 312 COSMIC
COSN32061574 329 COSMIC
COSN26644235 341 COSMIC
COSN17761791 351 COSMIC
COSN26574907 355 COSMIC
COSN30544791 377 COSMIC
COSN26555898 378 COSMIC
COSN31544099 395 COSMIC
COSN31608364 523 COSMIC
COSN29467877 524 COSMIC
COSN30544824 553 COSMIC
COSN27396117 728 COSMIC
COSN27462581 729 COSMIC
COSN29357844 959 COSMIC
COSN28939445 965 COSMIC
COSN21431554 974 COSMIC
COSN7197820 990 COSMIC
COSN16449829 1383 COSMIC
COSN26713063 1493 COSMIC
COSN8428286 1760 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1162759417 5 dbSNP
rs1425199419 7 dbSNP
rs771841506 11 dbSNP
rs1259770831 17 dbSNP
rs748135498 17 dbSNP
rs1374201308 18 dbSNP
rs774315324 20 dbSNP
rs1166474518 21 dbSNP
rs573995191 23 dbSNP
rs1183525332 25 dbSNP
rs899692165 31 dbSNP
rs1214275850 32 dbSNP
rs1393331573 33 dbSNP
rs377661439 33 dbSNP
rs1034066469 37 dbSNP
rs781078928 38 dbSNP
rs1285368369 39 dbSNP
rs1222263980 41 dbSNP
rs757561925 48 dbSNP
rs534302212 54 dbSNP
rs1226614902 55 dbSNP
rs566897310 64 dbSNP
rs1334542168 65 dbSNP
rs1041623941 66 dbSNP
rs949789981 78 dbSNP
rs1361408198 80 dbSNP
rs1222768919 81 dbSNP
rs551894990 83 dbSNP
rs540071956 84 dbSNP
rs1489625956 89 dbSNP
rs1218106299 96 dbSNP
rs1010331128 97 dbSNP
rs1191679412 100 dbSNP
rs891688737 104 dbSNP
rs1179769864 107 dbSNP
rs1459484768 108 dbSNP
rs1421774933 117 dbSNP
rs1289457397 127 dbSNP
rs1239411047 128 dbSNP
rs916921868 132 dbSNP
rs1193558519 140 dbSNP
rs569449684 149 dbSNP
rs1055977130 159 dbSNP
rs1246507447 162 dbSNP
rs201032582 164 dbSNP
rs1356777928 170 dbSNP
rs937096000 174 dbSNP
rs1260743016 175 dbSNP
rs1485292434 181 dbSNP
rs920318597 185 dbSNP
rs1245548936 190 dbSNP
rs549327975 201 dbSNP
rs1240706511 207 dbSNP
rs1039095054 212 dbSNP
rs1441717083 215 dbSNP
rs1160187164 217 dbSNP
rs974212942 227 dbSNP
rs962815111 232 dbSNP
rs1156721072 237 dbSNP
rs1047690565 249 dbSNP
rs1379003985 252 dbSNP
rs1335764761 254 dbSNP
rs1326846848 258 dbSNP
rs766940206 259 dbSNP
rs929314460 266 dbSNP
rs1307345377 273 dbSNP
rs1403061954 283 dbSNP
rs1304756215 286 dbSNP
rs1433127372 287 dbSNP
rs1394788135 288 dbSNP
rs920816405 289 dbSNP
rs1159643558 296 dbSNP
rs780680157 297 dbSNP
rs1177970390 298 dbSNP
rs3210270 298 dbSNP
rs1250139788 300 dbSNP
rs3204322 300 dbSNP
rs1181771444 301 dbSNP
rs1430079460 301 dbSNP
rs1175688575 302 dbSNP
rs1470200232 302 dbSNP
rs1436704772 306 dbSNP
rs1256275257 309 dbSNP
rs1223437948 310 dbSNP
rs1284565669 310 dbSNP
rs1372094260 310 dbSNP
rs1389350647 310 dbSNP
rs1463369318 310 dbSNP
rs551314475 310 dbSNP
rs926817624 310 dbSNP
rs1201748653 311 dbSNP
rs1205605014 312 dbSNP
rs1484491433 312 dbSNP
rs908831890 315 dbSNP
rs979835225 323 dbSNP
rs1470756928 324 dbSNP
rs1479743580 324 dbSNP
rs1480188619 324 dbSNP
rs983049707 324 dbSNP
rs1198560581 325 dbSNP
rs1423036283 325 dbSNP
rs1217058164 326 dbSNP
rs1353710335 326 dbSNP
rs971107948 326 dbSNP
rs1355635384 327 dbSNP
rs1304654753 328 dbSNP
rs1365629622 329 dbSNP
rs376462698 330 dbSNP
rs1403856455 336 dbSNP
rs1280836717 337 dbSNP
rs1364650604 337 dbSNP
rs1277676746 338 dbSNP
rs955579979 340 dbSNP
rs772537194 344 dbSNP
rs988456659 345 dbSNP
rs1341099492 350 dbSNP
rs997223586 355 dbSNP
rs11811745 357 dbSNP
rs964142947 368 dbSNP
rs955907638 369 dbSNP
rs1292827969 374 dbSNP
rs1490200643 375 dbSNP
rs1220281087 379 dbSNP
rs35753959 383 dbSNP
rs1033055912 384 dbSNP
rs748414064 390 dbSNP
rs903011888 394 dbSNP
rs1041697609 395 dbSNP
rs779505992 411 dbSNP
rs190693169 412 dbSNP
rs1055479798 415 dbSNP
rs936961547 417 dbSNP
rs753982825 425 dbSNP
rs185051622 429 dbSNP
rs890515121 436 dbSNP
rs1320940093 437 dbSNP
rs941569302 438 dbSNP
rs1432095956 445 dbSNP
rs1288862721 447 dbSNP
rs1360273280 450 dbSNP
rs548753007 452 dbSNP
rs1316198351 454 dbSNP
rs983466715 455 dbSNP
rs934272748 465 dbSNP
rs929288868 467 dbSNP
rs1317652380 468 dbSNP
rs1473433039 472 dbSNP
rs1368477233 473 dbSNP
rs1188999075 477 dbSNP
rs1463507611 477 dbSNP
rs527271706 482 dbSNP
rs1243537793 491 dbSNP
rs975442460 496 dbSNP
rs1161158272 502 dbSNP
rs1409521106 503 dbSNP
rs560026971 507 dbSNP
rs1400819754 508 dbSNP
rs1158987198 510 dbSNP
rs1256325608 513 dbSNP
rs1455084079 515 dbSNP
rs938291629 515 dbSNP
rs964006041 516 dbSNP
rs544684228 523 dbSNP
rs577437165 524 dbSNP
rs978839915 526 dbSNP
rs1351467895 536 dbSNP
rs1223246778 538 dbSNP
rs967230447 542 dbSNP
rs1020104587 555 dbSNP
rs982253323 558 dbSNP
rs1460760063 561 dbSNP
rs192265035 562 dbSNP
rs1356982859 565 dbSNP
rs1176081309 568 dbSNP
rs544110999 570 dbSNP
rs1267210722 579 dbSNP
rs1231525928 587 dbSNP
rs573807658 590 dbSNP
rs1409136484 603 dbSNP
rs916969567 604 dbSNP
rs555630345 618 dbSNP
rs756260748 621 dbSNP
rs533978052 637 dbSNP
rs560427353 659 dbSNP
rs1331319529 670 dbSNP
rs1336538118 677 dbSNP
rs1001188172 678 dbSNP
rs1286473968 685 dbSNP
rs1347533271 686 dbSNP
rs1325011994 697 dbSNP
rs1318084677 702 dbSNP
rs1365508471 702 dbSNP
rs78360744 704 dbSNP
rs776158671 710 dbSNP
rs1406372123 717 dbSNP
rs573174815 719 dbSNP
rs1163450187 721 dbSNP
rs1459391550 724 dbSNP
rs1322531223 726 dbSNP
rs1416553020 727 dbSNP
rs1193883420 728 dbSNP
rs1037434760 729 dbSNP
rs558311402 733 dbSNP
rs964567739 737 dbSNP
rs886159205 739 dbSNP
rs1017490746 740 dbSNP
rs140983887 740 dbSNP
rs796470955 740 dbSNP
rs1200758715 751 dbSNP
rs1429144662 759 dbSNP
rs1047244884 768 dbSNP
rs934113192 786 dbSNP
rs79617453 787 dbSNP
rs976062917 788 dbSNP
rs759170042 789 dbSNP
rs925927722 794 dbSNP
rs1282750226 799 dbSNP
rs1192184752 804 dbSNP
rs1230978048 807 dbSNP
rs1271657108 811 dbSNP
rs938012959 814 dbSNP
rs1227203567 815 dbSNP
rs1272087161 818 dbSNP
rs905406543 831 dbSNP
rs765907268 838 dbSNP
rs1267563541 839 dbSNP
rs1046691851 851 dbSNP
rs1452036849 853 dbSNP
rs949525408 855 dbSNP
rs914113830 863 dbSNP
rs1475316623 864 dbSNP
rs1052857346 865 dbSNP
rs978871240 873 dbSNP
rs967470791 874 dbSNP
rs1302548396 877 dbSNP
rs925736370 886 dbSNP
rs1020766547 888 dbSNP
rs1384991735 889 dbSNP
rs1478648870 890 dbSNP
rs1320284398 892 dbSNP
rs1326771874 895 dbSNP
rs978808306 903 dbSNP
rs1295170981 906 dbSNP
rs992680459 909 dbSNP
rs960133043 919 dbSNP
rs1246275404 923 dbSNP
rs964347980 924 dbSNP
rs1034308333 930 dbSNP
rs1220629165 931 dbSNP
rs1001387309 933 dbSNP
rs1269895590 936 dbSNP
rs1128817 937 dbSNP
rs1445399464 938 dbSNP
rs1333237534 948 dbSNP
rs1324406279 953 dbSNP
rs1015894315 957 dbSNP
rs1440861140 964 dbSNP
rs767583788 986 dbSNP
rs1393011084 988 dbSNP
rs1455447627 990 dbSNP
rs886192201 999 dbSNP
rs954542131 1000 dbSNP
rs1385532169 1002 dbSNP
rs1051916820 1004 dbSNP
rs1026589625 1017 dbSNP
rs1384797765 1021 dbSNP
rs1452914867 1033 dbSNP
rs1311623633 1034 dbSNP
rs934210361 1046 dbSNP
rs1416943625 1047 dbSNP
rs901336007 1053 dbSNP
rs1260832137 1062 dbSNP
rs1039979843 1063 dbSNP
rs942919249 1065 dbSNP
rs926165861 1071 dbSNP
rs1478221867 1073 dbSNP
rs1043100544 1076 dbSNP
rs945993776 1077 dbSNP
rs1181464266 1083 dbSNP
rs1002172057 1086 dbSNP
rs1421142648 1086 dbSNP
rs1182534366 1090 dbSNP
rs1363315571 1092 dbSNP
rs905229814 1095 dbSNP
rs551152314 1098 dbSNP
rs913347808 1106 dbSNP
rs1407995732 1109 dbSNP
rs1238812153 1112 dbSNP
rs1200594572 1115 dbSNP
rs1302073385 1117 dbSNP
rs1436188945 1118 dbSNP
rs1392774566 1122 dbSNP
rs1307009923 1123 dbSNP
rs1272531298 1125 dbSNP
rs1019397983 1136 dbSNP
rs1220054592 1136 dbSNP
rs1328511087 1141 dbSNP
rs10666591 1142 dbSNP
rs187093892 1142 dbSNP
rs1347524559 1146 dbSNP
rs892625280 1151 dbSNP
rs1481708825 1153 dbSNP
rs1196660616 1155 dbSNP
rs1251166023 1155 dbSNP
rs1471676536 1155 dbSNP
rs34371654 1155 dbSNP
rs5780025 1155 dbSNP
rs1301707831 1156 dbSNP
rs1357224480 1158 dbSNP
rs959921708 1158 dbSNP
rs1463184505 1162 dbSNP
rs1298457964 1163 dbSNP
rs1369369159 1164 dbSNP
rs1407507211 1168 dbSNP
rs568702998 1172 dbSNP
rs1346624486 1179 dbSNP
rs547259920 1181 dbSNP
rs1219174679 1186 dbSNP
rs979875563 1187 dbSNP
rs1228394003 1188 dbSNP
rs1274258004 1196 dbSNP
rs1224769174 1199 dbSNP
rs1269698804 1200 dbSNP
rs963281956 1202 dbSNP
rs1334030220 1206 dbSNP
rs1443705090 1212 dbSNP
rs1190600748 1216 dbSNP
rs1352313954 1217 dbSNP
rs1422791417 1222 dbSNP
rs1430126448 1231 dbSNP
rs1053001867 1233 dbSNP
rs1016094414 1246 dbSNP
rs1327712522 1247 dbSNP
rs527319362 1248 dbSNP
rs773137348 1250 dbSNP
rs925653571 1251 dbSNP
rs1436385597 1255 dbSNP
rs1292333563 1258 dbSNP
rs1364501047 1260 dbSNP
rs1383083871 1261 dbSNP
rs1042794979 1263 dbSNP
rs943030414 1270 dbSNP
rs6668164 1271 dbSNP
rs1292568120 1283 dbSNP
rs1321262665 1292 dbSNP
rs142690378 1302 dbSNP
rs1244960173 1311 dbSNP
rs1030121044 1313 dbSNP
rs184307307 1315 dbSNP
rs1486818788 1318 dbSNP
rs997657109 1334 dbSNP
rs901371563 1338 dbSNP
rs1447271181 1345 dbSNP
rs771893847 1358 dbSNP
rs1413847902 1361 dbSNP
rs1404300533 1363 dbSNP
rs1162122111 1364 dbSNP
rs954655252 1367 dbSNP
rs919199111 1377 dbSNP
rs562709543 1386 dbSNP
rs972269555 1386 dbSNP
rs963251940 1390 dbSNP
rs1016754207 1398 dbSNP
rs1378502191 1412 dbSNP
rs1007042612 1418 dbSNP
rs1232380220 1420 dbSNP
rs1211040911 1435 dbSNP
rs1002330481 1440 dbSNP
rs1286466758 1440 dbSNP
rs969360874 1446 dbSNP
rs1267254758 1457 dbSNP
rs1278519568 1458 dbSNP
rs1463411108 1478 dbSNP
rs544609391 1485 dbSNP
rs1237648634 1486 dbSNP
rs532824244 1494 dbSNP
rs946106149 1499 dbSNP
rs148204949 1500 dbSNP
rs1312078193 1503 dbSNP
rs191801113 1506 dbSNP
rs913203585 1507 dbSNP
rs1159158078 1508 dbSNP
rs1386866164 1509 dbSNP
rs1471188506 1512 dbSNP
rs1335298677 1516 dbSNP
rs1358760775 1518 dbSNP
rs1446097140 1525 dbSNP
rs1281339923 1531 dbSNP
rs747950425 1532 dbSNP
rs143393661 1535 dbSNP
rs938776961 1548 dbSNP
rs1205289994 1564 dbSNP
rs575261245 1565 dbSNP
rs1312300411 1570 dbSNP
rs149220070 1573 dbSNP
rs1207653317 1583 dbSNP
rs1448233893 1586 dbSNP
rs904054024 1587 dbSNP
rs1483118491 1589 dbSNP
rs573731036 1594 dbSNP
rs979908274 1600 dbSNP
rs573176173 1601 dbSNP
rs1310773993 1605 dbSNP
rs558147727 1610 dbSNP
rs774307259 1632 dbSNP
rs187472952 1633 dbSNP
rs888769535 1635 dbSNP
rs575760392 1638 dbSNP
rs1051355257 1641 dbSNP
rs866640402 1642 dbSNP
rs1409233529 1665 dbSNP
rs879647780 1679 dbSNP
rs1348484389 1695 dbSNP
rs1235349321 1696 dbSNP
rs909168087 1697 dbSNP
rs1275209252 1706 dbSNP
rs1182497845 1712 dbSNP
rs919135461 1716 dbSNP
rs1217083974 1725 dbSNP
rs1274735467 1727 dbSNP
rs1255661870 1729 dbSNP
rs983329778 1730 dbSNP
rs1187573889 1735 dbSNP
rs1203759349 1739 dbSNP
rs1248990371 1748 dbSNP
rs1488787661 1754 dbSNP
rs941857819 1776 dbSNP
rs1246457809 1779 dbSNP
rs1477273794 1781 dbSNP
rs145308442 1783 dbSNP
rs909071784 1784 dbSNP
rs1030398728 1795 dbSNP
rs1166735847 1796 dbSNP
rs775400303 1798 dbSNP
rs1009062576 1804 dbSNP
rs1388438120 1805 dbSNP
rs772883377 1810 dbSNP
rs769332831 1813 dbSNP
rs11804058 1814 dbSNP
rs758948231 1824 dbSNP
rs1299583391 1831 dbSNP
rs1233364565 1834 dbSNP
rs568620603 1843 dbSNP
rs553414616 1855 dbSNP
rs535290065 1856 dbSNP
rs1413795820 1857 dbSNP
rs1043350358 1861 dbSNP
rs1450425665 1864 dbSNP
rs956740793 1864 dbSNP
rs1290436376 1866 dbSNP
rs1195701747 1870 dbSNP
rs1249052123 1873 dbSNP
rs1031664188 1876 dbSNP
rs1186986732 1878 dbSNP
rs1344503022 1883 dbSNP
rs1458515529 1901 dbSNP
rs1162758910 1907 dbSNP
rs1010890483 1908 dbSNP
rs776369238 1910 dbSNP
rs1165476254 1914 dbSNP
rs1322233366 1918 dbSNP
rs1463065404 1921 dbSNP
rs1057445984 1923 dbSNP
rs1018426574 1932 dbSNP
rs1007026566 1933 dbSNP
rs1341918399 1947 dbSNP
rs888825422 1948 dbSNP
rs1051467070 1949 dbSNP
rs932971749 1953 dbSNP
rs1354793739 1959 dbSNP
rs566141007 1960 dbSNP
rs878983681 1965 dbSNP
rs897527388 1979 dbSNP
rs182919435 1983 dbSNP
rs905964754 1992 dbSNP
rs1245142508 1993 dbSNP
rs532763865 1997 dbSNP
rs941984834 1998 dbSNP
rs1186843957 2000 dbSNP
rs770451873 2002 dbSNP
rs941908187 2003 dbSNP
rs909032723 2007 dbSNP
rs1161367347 2013 dbSNP
rs1456462928 2016 dbSNP
rs775758341 2016 dbSNP
rs980579919 2024 dbSNP
rs568650903 2025 dbSNP
rs780554081 2045 dbSNP
rs748550321 2049 dbSNP
rs1336214953 2053 dbSNP
rs1270763719 2065 dbSNP
rs917974550 2067 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uuaccauuaccaagaGAACGAu 5'
                         |||||| 
Target 5' ------ucaucaaaaCUUGCUa 3'
 		1 - 16
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000294740.3 | 3UTR | UCAUCAAAACUUGCUAUGAACUCUAAUUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
124 hsa-miR-451b Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT060018 VANGL2 VANGL planar cell polarity protein 2 2 4
MIRT069874 SRP54 signal recognition particle 54 2 2
MIRT088316 RAB10 RAB10, member RAS oncogene family 2 4
MIRT100747 VEGFA vascular endothelial growth factor A 5 12
MIRT152236 ZNF460 zinc finger protein 460 2 2
MIRT198492 USP14 ubiquitin specific peptidase 14 2 6
MIRT204750 BZW1 basic leucine zipper and W2 domains 1 2 12
MIRT211209 FGF2 fibroblast growth factor 2 2 2
MIRT234352 MSL1 male specific lethal 1 homolog 2 8
MIRT281810 MAP2K1 mitogen-activated protein kinase kinase 1 2 2
MIRT369113 CKMT1A creatine kinase, mitochondrial 1A 2 2
MIRT401349 C5ORF51 chromosome 5 open reading frame 51 2 4
MIRT441509 ERN1 endoplasmic reticulum to nucleus signaling 1 2 2
MIRT441888 RD3 retinal degeneration 3 2 4
MIRT443549 GPR35 G protein-coupled receptor 35 2 2
MIRT444959 ADAM22 ADAM metallopeptidase domain 22 2 2
MIRT445808 NFATC2 nuclear factor of activated T-cells 2 2 2
MIRT446509 ASCC1 activating signal cointegrator 1 complex subunit 1 2 2
MIRT447457 ST18 ST18, C2H2C-type zinc finger 2 2
MIRT448296 ZDHHC3 zinc finger DHHC-type containing 3 2 2
MIRT463178 ZNF281 zinc finger protein 281 2 2
MIRT466606 TBC1D13 TBC1 domain family member 13 2 2
MIRT467235 SPRED1 sprouty related EVH1 domain containing 1 2 2
MIRT471039 PISD phosphatidylserine decarboxylase 2 10
MIRT471892 NUAK2 NUAK family kinase 2 2 2
MIRT474151 LIMA1 LIM domain and actin binding 1 2 6
MIRT474155 LIFR LIF receptor alpha 2 2
MIRT481037 BAZ2A bromodomain adjacent to zinc finger domain 2A 2 2
MIRT483083 GPR75 G protein-coupled receptor 75 2 4
MIRT485208 PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha 2 8
MIRT495187 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT495431 ATG7 autophagy related 7 2 2
MIRT499160 FAM83C family with sequence similarity 83 member C 2 6
MIRT499505 GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 2 2
MIRT500400 ZMAT3 zinc finger matrin-type 3 2 10
MIRT500684 TRIM37 tripartite motif containing 37 2 2
MIRT501301 RPS6KB1 ribosomal protein S6 kinase B1 2 2
MIRT504339 ASGR2 asialoglycoprotein receptor 2 2 6
MIRT505931 RCAN3 RCAN family member 3 2 4
MIRT513196 SLU7 SLU7 homolog, splicing factor 2 2
MIRT521807 POM121C POM121 transmembrane nucleoporin C 2 2
MIRT522779 LAMP2 lysosomal associated membrane protein 2 2 6
MIRT530179 ZBED2 zinc finger BED-type containing 2 2 2
MIRT532397 SNX3 sorting nexin 3 2 2
MIRT532482 HOXA13 homeobox A13 2 2
MIRT532538 WDR13 WD repeat domain 13 2 2
MIRT534779 RAN RAN, member RAS oncogene family 2 2
MIRT535719 N4BP1 NEDD4 binding protein 1 2 2
MIRT539310 AKAP12 A-kinase anchoring protein 12 2 4
MIRT539877 RPL32 ribosomal protein L32 2 2
MIRT539891 IRGQ immunity related GTPase Q 2 2
MIRT540063 CEP104 centrosomal protein 104 2 2
MIRT540154 GTF2B general transcription factor IIB 2 4
MIRT540206 ARHGAP18 Rho GTPase activating protein 18 2 2
MIRT540391 CRTC1 CREB regulated transcription coactivator 1 2 2
MIRT540595 ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit 2 4
MIRT540733 FABP2 fatty acid binding protein 2 2 2
MIRT540949 SLC25A43 solute carrier family 25 member 43 2 2
MIRT541444 C18orf32 chromosome 18 open reading frame 32 2 4
MIRT541571 ZNF43 zinc finger protein 43 2 4
MIRT541601 ALOX15 arachidonate 15-lipoxygenase 2 2
MIRT541933 ORC1 origin recognition complex subunit 1 2 4
MIRT542394 WDR12 WD repeat domain 12 2 2
MIRT542414 SYNJ2BP synaptojanin 2 binding protein 2 2
MIRT542481 APOC3 apolipoprotein C3 2 2
MIRT542621 XIAP X-linked inhibitor of apoptosis 2 2
MIRT542976 FAM83F family with sequence similarity 83 member F 2 2
MIRT543741 DHCR7 7-dehydrocholesterol reductase 2 2
MIRT544594 AP5Z1 adaptor related protein complex 5 zeta 1 subunit 2 4
MIRT546441 SNX5 sorting nexin 5 2 2
MIRT548213 FKBP1A FK506 binding protein 1A 2 2
MIRT550471 OSCAR osteoclast associated, immunoglobulin-like receptor 2 4
MIRT555230 PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 2 4
MIRT555428 PPAP2B phospholipid phosphatase 3 2 2
MIRT556368 MAF MAF bZIP transcription factor 2 2
MIRT558149 ELK4 ELK4, ETS transcription factor 2 2
MIRT566181 PTPN14 protein tyrosine phosphatase, non-receptor type 14 2 2
MIRT568468 ARMC12 armadillo repeat containing 12 2 2
MIRT607594 TANGO2 transport and golgi organization 2 homolog 2 2
MIRT617588 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT621244 SIGLEC9 sialic acid binding Ig like lectin 9 2 4
MIRT623679 HOXD4 homeobox D4 2 2
MIRT625989 FGFR1OP FGFR1 oncogene partner 2 4
MIRT627244 ZBTB3 zinc finger and BTB domain containing 3 2 2
MIRT632946 ELOVL6 ELOVL fatty acid elongase 6 2 4
MIRT635872 SLC11A2 solute carrier family 11 member 2 2 2
MIRT636638 CHAF1B chromatin assembly factor 1 subunit B 2 2
MIRT643563 WDR73 WD repeat domain 73 2 2
MIRT647907 CIRH1A UTP4, small subunit processome component 2 2
MIRT652503 TMEM170A transmembrane protein 170A 2 2
MIRT652843 TACO1 translational activator of cytochrome c oxidase I 2 2
MIRT653299 SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 2 2
MIRT659383 CREG2 cellular repressor of E1A stimulated genes 2 2 2
MIRT661339 TBC1D15 TBC1 domain family member 15 2 2
MIRT662372 ANKRD42 ankyrin repeat domain 42 2 2
MIRT664322 CD209 CD209 molecule 2 2
MIRT671759 F11R F11 receptor 2 2
MIRT673240 KLHDC8A kelch domain containing 8A 2 2
MIRT682871 C9orf156 tRNA methyltransferase O 2 2
MIRT683171 SF3A1 splicing factor 3a subunit 1 2 2
MIRT684262 TBXA2R thromboxane A2 receptor 2 2
MIRT684395 MCTS1 MCTS1, re-initiation and release factor 2 2
MIRT684883 P4HB prolyl 4-hydroxylase subunit beta 2 2
MIRT686650 TMEM184C transmembrane protein 184C 2 2
MIRT687771 KIAA0355 KIAA0355 2 2
MIRT694352 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT696347 SLC35D2 solute carrier family 35 member D2 2 2
MIRT700480 PUM1 pumilio RNA binding family member 1 2 2
MIRT705909 ADAM9 ADAM metallopeptidase domain 9 2 2
MIRT714076 FNDC3B fibronectin type III domain containing 3B 2 2
MIRT714401 FBXO31 F-box protein 31 2 2
MIRT716442 RPS24 ribosomal protein S24 2 2
MIRT718204 PSMF1 proteasome inhibitor subunit 1 2 2
MIRT721238 CRCP CGRP receptor component 2 2
MIRT721271 SH3D19 SH3 domain containing 19 2 2
MIRT721603 ZNF484 zinc finger protein 484 2 2
MIRT722916 COA4 cytochrome c oxidase assembly factor 4 homolog 2 2
MIRT723457 CUL4A cullin 4A 2 2
MIRT733813 KREMEN1 kringle containing transmembrane protein 1 2 0
MIRT733814 CASK calcium/calmodulin dependent serine protein kinase 2 0
MIRT733815 KLF4 Kruppel like factor 4 2 0
MIRT733816 BCL2 BCL2, apoptosis regulator 2 0
MIRT733817 PCNA proliferating cell nuclear antigen 2 0
MIRT733818 BAX BCL2 associated X, apoptosis regulator 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-451b Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (A2780CIS)
hsa-miR-451b Trastuzumab sensitive High HER2-Positive Breast Cancer tissue
hsa-mir-451b Cisplatin 5460033 NSC119875 approved sensitive cell line (CP20)
hsa-mir-451b Cisplatin 5460033 NSC119875 approved sensitive cell line (CIS)
hsa-miR-451b Neoadjuvant chemotherapy sensitive tissue (breast cancer)

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