pre-miRNA Information
pre-miRNA hsa-mir-367   
Genomic Coordinates chr4: 112647874 - 112647941
Synonyms MIRN367, hsa-mir-367, MIR367
Description Homo sapiens miR-367 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-367-3p
Sequence 44| AAUUGCACUUUAGCAAUGGUGA |65
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN24411246 17 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs535597757 1 dbSNP
rs1013348949 11 dbSNP
rs896333735 12 dbSNP
rs751269136 14 dbSNP
rs1163501507 16 dbSNP
rs757092597 21 dbSNP
Putative Targets

Gene Information
Gene Symbol ZC3HAV1L   
Synonyms C7orf39
Description zinc finger CCCH-type containing, antiviral 1 like
Transcript NM_080660   
Expression
Putative miRNA Targets on ZC3HAV1L
3'UTR of ZC3HAV1L
(miRNA target sites are highlighted)
>ZC3HAV1L|NM_080660|3'UTR
   1 AGAAGATGGAAAAGGAGAAAATGTCCTTTTGGAAGAATACATTTGGGCATGGGTGGTTGGGGATGGGGTGGGACATTGAA
  81 CAGGCAAAGAGAGGCTAAAATTGAGTGCAGATGGGGCTAGTCCAGGGCAAGTGCTGAAGATGGCAGCTGCTATCTGCAGC
 161 TCCTAGGTGCTTTCCTCAGGCTGGGTAGATGGAGCTCTGCTGACTTCTGTGGTCCACCATTGTTTTTCTATCAATTTATA
 241 TTGTGGCAATCCTAGAGTACTTTGCACTCATTTTTTTTTTTCACTTAATATTGTCTCATAAGCATCTTTCTATATTTGTT
 321 CACATCGTACATAATCATGTTTTTGCACAGATACATTAATATTATCATAGTTTGTTTAACTACTTGGCTTTTTCTAACAG
 401 TTTTTTTTTTTGAGATGGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGACGTGATCTCGGCTCACTGCAGCCTTGACT
 481 TCCTGGGCTCAAGTGATCATCCCACCTCAGCCTCCTGAGTAGCTGGGACTACAGGTATGCACCACGACCAGCTAATTTTT
 561 TGTATTTTTTTTTTGTAGAGAGGGTATTTTGCCATGTTGCCCAGGCTAGTCTTGAACTCCTGGGCTCAAGCGATCTGCCT
 641 GCTTCAGCCTCCCAGAGTGCTAGGATTACAGGCATGAGCCACTGCACCCAGCCTCTTAACAAATTTTGAATATAACTCCT
 721 GTCTTAAAATCTGCAGAATATTGAATTTTTCCAGCTATTTTTTACTTTTGCTTAGCTTATAGATGCTAAAGGATACTGTC
 801 ATTTGCATTTTTAAAAATATATGTATGAGTGAATAGTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
 881 AAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' aguGGUAACGAUUUCACGUUAa 5'
             |||  |||::||||||:| 
Target 5' tgcCCA-GGCTGGAGTGCAGTg 3'
430 - 450 150.00 -19.20
2
miRNA  3' agUGG-UAACGAUUUCA-CGUUAa 5'
            |:| |||  ||  || ||||| 
Target 5' ctATCAATTTATATTGTGGCAATc 3'
228 - 251 124.00 -6.20
3
miRNA  3' agugguaaCGAUU-----UCACGU-UAa 5'
                  |||||     |||||| || 
Target 5' aaagagagGCTAAAATTGAGTGCAGATg 3'
86 - 113 122.00 -10.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30510389 21 COSMIC
COSN19121951 25 COSMIC
COSN27005549 27 COSMIC
COSN27005550 27 COSMIC
COSN27005551 56 COSMIC
COSN30537309 72 COSMIC
COSN27005552 78 COSMIC
COSN30527012 192 COSMIC
COSN20104862 270 COSMIC
COSN27589700 271 COSMIC
COSN28490554 564 COSMIC
COSN6353940 586 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1376637662 1 dbSNP
rs947907641 7 dbSNP
rs765419069 11 dbSNP
rs1336542248 14 dbSNP
rs781634462 17 dbSNP
rs759784808 20 dbSNP
rs111891533 31 dbSNP
rs894983722 37 dbSNP
rs556361392 41 dbSNP
rs771009734 43 dbSNP
rs115015323 44 dbSNP
rs1180234812 45 dbSNP
rs773656153 48 dbSNP
rs939267774 49 dbSNP
rs1245749767 51 dbSNP
rs532924358 56 dbSNP
rs867239563 63 dbSNP
rs150537133 68 dbSNP
rs923835216 81 dbSNP
rs977813485 84 dbSNP
rs77941163 86 dbSNP
rs915034411 90 dbSNP
rs115752120 94 dbSNP
rs1400454685 103 dbSNP
rs1370434817 104 dbSNP
rs953760331 105 dbSNP
rs1029131696 110 dbSNP
rs141661116 116 dbSNP
rs1227927738 126 dbSNP
rs112444031 127 dbSNP
rs1015580898 131 dbSNP
rs551368712 136 dbSNP
rs946719068 137 dbSNP
rs1467678895 145 dbSNP
rs1192250748 164 dbSNP
rs1264515397 177 dbSNP
rs1429412112 178 dbSNP
rs1409835306 193 dbSNP
rs1371757622 208 dbSNP
rs913879425 214 dbSNP
rs1165978954 215 dbSNP
rs189911848 216 dbSNP
rs550650377 228 dbSNP
rs939425157 229 dbSNP
rs1027619024 230 dbSNP
rs1012346505 231 dbSNP
rs757123559 233 dbSNP
rs928510353 234 dbSNP
rs767975062 239 dbSNP
rs1294570607 257 dbSNP
rs1338194753 263 dbSNP
rs562662249 265 dbSNP
rs1234722320 266 dbSNP
rs1257038935 266 dbSNP
rs542739746 267 dbSNP
rs1484374515 270 dbSNP
rs1238069907 271 dbSNP
rs76876234 271 dbSNP
rs1188866842 282 dbSNP
rs1486470190 282 dbSNP
rs369793399 282 dbSNP
rs879880075 282 dbSNP
rs969831772 283 dbSNP
rs1474228980 290 dbSNP
rs1161394535 299 dbSNP
rs1056334824 300 dbSNP
rs1023318672 301 dbSNP
rs939153378 303 dbSNP
rs1259978273 310 dbSNP
rs1358337816 310 dbSNP
rs1293451817 321 dbSNP
rs902460859 327 dbSNP
rs76416666 329 dbSNP
rs560777662 330 dbSNP
rs374018128 337 dbSNP
rs137891636 339 dbSNP
rs185983316 346 dbSNP
rs932422466 352 dbSNP
rs145210962 353 dbSNP
rs1212050476 355 dbSNP
rs1257007727 365 dbSNP
rs1484807395 369 dbSNP
rs1179243930 370 dbSNP
rs1408777709 372 dbSNP
rs10265929 387 dbSNP
rs1158235908 389 dbSNP
rs1439467323 392 dbSNP
rs576179189 401 dbSNP
rs1173503491 402 dbSNP
rs908157689 408 dbSNP
rs1044387918 412 dbSNP
rs1445314107 412 dbSNP
rs373451520 412 dbSNP
rs899968505 412 dbSNP
rs1299580550 414 dbSNP
rs1011139231 422 dbSNP
rs1390350626 423 dbSNP
rs984113653 427 dbSNP
rs1417536550 428 dbSNP
rs1163141826 431 dbSNP
rs1235745247 436 dbSNP
rs1280060855 437 dbSNP
rs952296622 439 dbSNP
rs1027674781 440 dbSNP
rs1310855396 443 dbSNP
rs866135024 443 dbSNP
rs1012235252 447 dbSNP
rs1257206423 452 dbSNP
rs1176672961 453 dbSNP
rs1052384325 456 dbSNP
rs1456537626 458 dbSNP
rs777541847 460 dbSNP
rs959472076 465 dbSNP
rs111743133 469 dbSNP
rs1412570667 472 dbSNP
rs1270974400 483 dbSNP
rs1354760857 485 dbSNP
rs1440757787 485 dbSNP
rs143088993 487 dbSNP
rs1442245259 501 dbSNP
rs902345072 503 dbSNP
rs1303339496 507 dbSNP
rs1365878201 510 dbSNP
rs1045099913 523 dbSNP
rs1273906769 525 dbSNP
rs948580518 532 dbSNP
rs1197054772 535 dbSNP
rs1275090104 536 dbSNP
rs915729916 537 dbSNP
rs112290712 542 dbSNP
rs1246089521 543 dbSNP
rs1476882680 545 dbSNP
rs536005983 546 dbSNP
rs1188065990 550 dbSNP
rs1420037245 551 dbSNP
rs1409008177 562 dbSNP
rs1168148203 564 dbSNP
rs77991415 565 dbSNP
rs1011251016 567 dbSNP
rs1461535500 568 dbSNP
rs1325740310 570 dbSNP
rs565459142 571 dbSNP
rs1433566444 575 dbSNP
rs893702696 575 dbSNP
rs962653088 575 dbSNP
rs1221544232 577 dbSNP
rs547042386 580 dbSNP
rs1295376366 592 dbSNP
rs1335509444 594 dbSNP
rs1213151607 595 dbSNP
rs769430504 596 dbSNP
rs1449781384 601 dbSNP
rs1217949207 603 dbSNP
rs1242457124 614 dbSNP
rs192029353 616 dbSNP
rs1419575911 617 dbSNP
rs1475215648 619 dbSNP
rs1390117542 620 dbSNP
rs112889923 622 dbSNP
rs1405041979 623 dbSNP
rs1388033018 624 dbSNP
rs1292145802 625 dbSNP
rs1402919119 631 dbSNP
rs1319610398 632 dbSNP
rs1459818533 635 dbSNP
rs1398575103 636 dbSNP
rs1314930002 641 dbSNP
rs1040768986 642 dbSNP
rs113856201 650 dbSNP
rs35318154 669 dbSNP
rs1282500710 671 dbSNP
rs1352988270 672 dbSNP
rs1225377646 691 dbSNP
rs908044388 693 dbSNP
rs768762390 702 dbSNP
rs1158699145 703 dbSNP
rs746889256 718 dbSNP
rs952420993 719 dbSNP
rs779966544 725 dbSNP
rs1366178294 726 dbSNP
rs754470649 745 dbSNP
rs537825870 755 dbSNP
rs115731935 758 dbSNP
rs549056439 762 dbSNP
rs906521852 764 dbSNP
rs1265255670 768 dbSNP
rs1211392422 770 dbSNP
rs1175903548 776 dbSNP
rs1376519152 783 dbSNP
rs1414370216 788 dbSNP
rs1337563180 795 dbSNP
rs959356426 800 dbSNP
rs116354985 813 dbSNP
rs1213950730 819 dbSNP
rs1352878081 823 dbSNP
rs1237948704 829 dbSNP
rs980289644 831 dbSNP
rs1348383257 836 dbSNP
rs187276264 839 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000275766.1 | 3UTR | AAUGGCGCGAUCUCAUCUCACCAUAACCUCCGCCUCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla 0.612 1.3e-2 0.620 1.2e-2 13 Click to see details
GSE26953 Aortic valvular endothelial cells -0.318 6.5e-2 -0.318 6.5e-2 24 Click to see details
GSE21849 B cell lymphoma -0.213 1.3e-1 0.261 8.6e-2 29 Click to see details
GSE17306 Multiple myeloma 0.16 1.4e-1 0.523 5.8e-5 49 Click to see details
GSE38226 Liver fibrosis 0.244 1.4e-1 0.227 1.6e-1 21 Click to see details
GSE32688 Pancreatic cancer 0.174 1.7e-1 0.181 1.6e-1 32 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.545 1.7e-1 -0.600 1.4e-1 5 Click to see details
GSE28544 Breast cancer -0.182 2.0e-1 -0.287 8.7e-2 24 Click to see details
GSE21687 Ependynoma primary tumors 0.103 2.1e-1 -0.099 2.2e-1 64 Click to see details
GSE27834 Pluripotent stem cells 0.173 2.6e-1 0.121 3.3e-1 16 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.121 2.8e-1 -0.211 1.6e-1 25 Click to see details
GSE42095 Differentiated embryonic stem cells 0.073 3.7e-1 -0.094 3.3e-1 23 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.057 4.1e-1 0.283 1.1e-1 20 Click to see details
GSE14794 Lymphoblastoid cells 0.02 4.3e-1 0.049 3.2e-1 90 Click to see details
GSE19350 CNS germ cell tumors 0.018 4.8e-1 0.175 2.9e-1 12 Click to see details
GSE19350 CNS germ cell tumors 0.018 4.8e-1 0.175 2.9e-1 12 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
255 hsa-miR-367-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055315 DUSP5 dual specificity phosphatase 5 2 8
MIRT055791 PLEKHA1 pleckstrin homology domain containing A1 2 12
MIRT057114 DDIT4 DNA damage inducible transcript 4 2 4
MIRT059663 GATAD2B GATA zinc finger domain containing 2B 2 2
MIRT059926 ZDHHC5 zinc finger DHHC-type containing 5 2 2
MIRT061610 BTG2 BTG anti-proliferation factor 2 2 6
MIRT066478 HMGA2 high mobility group AT-hook 2 2 2
MIRT069388 ZFYVE21 zinc finger FYVE-type containing 21 2 2
MIRT069972 GEMIN2 gem nuclear organelle associated protein 2 2 2
MIRT074764 CNEP1R1 CTD nuclear envelope phosphatase 1 regulatory subunit 1 2 2
MIRT076199 GID4 GID complex subunit 4 homolog 2 6
MIRT077512 UBE2Z ubiquitin conjugating enzyme E2 Z 2 4
MIRT077903 TOB1 transducer of ERBB2, 1 2 6
MIRT082250 MED29 mediator complex subunit 29 2 4
MIRT082434 CIC capicua transcriptional repressor 2 6
MIRT082474 PPP1R37 protein phosphatase 1 regulatory subunit 37 2 2
MIRT082778 ZNF264 zinc finger protein 264 2 2
MIRT084533 BCL2L11 BCL2 like 11 2 8
MIRT085309 UBXN4 UBX domain protein 4 2 8
MIRT086365 SSFA2 sperm specific antigen 2 2 8
MIRT087455 NF2 neurofibromin 2 2 2
MIRT088865 FOXN2 forkhead box N2 2 12
MIRT092185 ITPR1 inositol 1,4,5-trisphosphate receptor type 1 2 6
MIRT092326 EDEM1 ER degradation enhancing alpha-mannosidase like protein 1 2 6
MIRT093533 GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 2 6
MIRT096935 PAPD7 poly(A) RNA polymerase D7, non-canonical 2 8
MIRT097026 MAP1B microtubule associated protein 1B 2 4
MIRT099137 MYLIP myosin regulatory light chain interacting protein 2 6
MIRT099905 SOX4 SRY-box 4 2 12
MIRT102289 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 2 10
MIRT102507 KLHDC10 kelch domain containing 10 2 2
MIRT102891 INSIG1 insulin induced gene 1 2 2
MIRT109188 VMA21 VMA21, vacuolar ATPase assembly factor 2 4
MIRT124567 PRRC2B proline rich coiled-coil 2B 2 2
MIRT135568 SPRYD4 SPRY domain containing 4 2 2
MIRT161135 SLC25A36 solute carrier family 25 member 36 2 6
MIRT163995 KIAA1109 KIAA1109 2 4
MIRT164689 RNF4 ring finger protein 4 2 2
MIRT167705 HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 2 8
MIRT178956 USP28 ubiquitin specific peptidase 28 2 2
MIRT185717 ARNTL2 aryl hydrocarbon receptor nuclear translocator like 2 2 2
MIRT186264 TCEB3 elongin A 2 2
MIRT186537 TWF1 twinfilin actin binding protein 1 2 4
MIRT186628 COX20 COX20, cytochrome c oxidase assembly factor 2 8
MIRT189373 TXLNA taxilin alpha 2 4
MIRT197013 EIF1 eukaryotic translation initiation factor 1 2 10
MIRT206437 YIPF4 Yip1 domain family member 4 2 2
MIRT211228 FGF2 fibroblast growth factor 2 2 10
MIRT214529 C5ORF24 chromosome 5 open reading frame 24 2 2
MIRT216034 IL6ST interleukin 6 signal transducer 2 10
MIRT218084 TULP4 tubby like protein 4 2 2
MIRT242418 CCDC113 coiled-coil domain containing 113 2 2
MIRT243162 SOX11 SRY-box 11 2 2
MIRT250943 CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 2 4
MIRT253350 ZNF417 zinc finger protein 417 2 2
MIRT271968 ARF1 ADP ribosylation factor 1 2 2
MIRT273214 ZNF695 zinc finger protein 695 2 4
MIRT296114 SLC12A5 solute carrier family 12 member 5 2 2
MIRT301711 TEF TEF, PAR bZIP transcription factor 2 2
MIRT316477 ARID1B AT-rich interaction domain 1B 2 6
MIRT322174 CLN8 CLN8, transmembrane ER and ERGIC protein 2 4
MIRT341538 CNIH1 cornichon family AMPA receptor auxiliary protein 1 2 6
MIRT356062 SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 2 2
MIRT443579 PPIC peptidylprolyl isomerase C 2 2
MIRT448825 FKBP1A FK506 binding protein 1A 2 4
MIRT451494 FOPNL FGFR1OP N-terminal like 2 2
MIRT452694 MDM2 MDM2 proto-oncogene 2 2
MIRT453167 CNOT4 CCR4-NOT transcription complex subunit 4 2 6
MIRT454588 SLC33A1 solute carrier family 33 member 1 2 4
MIRT455794 TAF8 TATA-box binding protein associated factor 8 2 4
MIRT456010 CYP2C19 cytochrome P450 family 2 subfamily C member 19 2 2
MIRT456044 KIAA1586 KIAA1586 2 2
MIRT456763 TMEM239 transmembrane protein 239 2 4
MIRT458068 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT459230 MRPS21 mitochondrial ribosomal protein S21 2 2
MIRT459534 MFF mitochondrial fission factor 2 6
MIRT459759 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT460236 TNFRSF13C TNF receptor superfamily member 13C 2 2
MIRT461104 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT462924 ZNRF3 zinc and ring finger 3 2 2
MIRT463476 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT463516 ZBTB8B zinc finger and BTB domain containing 8B 2 4
MIRT465503 TOR1B torsin family 1 member B 2 2
MIRT469525 RBFOX2 RNA binding protein, fox-1 homolog 2 2 8
MIRT470079 PTGES2 prostaglandin E synthase 2 2 2
MIRT471581 PARD6B par-6 family cell polarity regulator beta 2 2
MIRT473451 MCOLN2 mucolipin 2 2 8
MIRT475882 H3F3C H3 histone family member 3C 2 10
MIRT475915 H3F3B H3 histone family member 3B 2 8
MIRT476195 GOLGA8A golgin A8 family member A 2 10
MIRT476318 GM2A GM2 ganglioside activator 2 2
MIRT476676 FUT11 fucosyltransferase 11 2 10
MIRT478368 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT479545 CDC5L cell division cycle 5 like 2 2
MIRT481024 BAZ2B bromodomain adjacent to zinc finger domain 2B 2 2
MIRT491009 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT493168 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT494345 CASKIN1 CASK interacting protein 1 2 2
MIRT499087 ZDHHC21 zinc finger DHHC-type containing 21 2 6
MIRT500029 ABCF2 ATP binding cassette subfamily F member 2 2 8
MIRT501298 RRN3 RRN3 homolog, RNA polymerase I transcription factor 2 4
MIRT503124 BCL11B B-cell CLL/lymphoma 11B 2 8
MIRT503301 GTF2A1 general transcription factor IIA subunit 1 2 6
MIRT504328 ASGR2 asialoglycoprotein receptor 2 2 6
MIRT504471 EID2B EP300 interacting inhibitor of differentiation 2B 2 2
MIRT504655 RPL9 ribosomal protein L9 2 6
MIRT505331 TMF1 TATA element modulatory factor 1 2 8
MIRT505732 SERTAD3 SERTA domain containing 3 2 4
MIRT505827 RSBN1 round spermatid basic protein 1 2 8
MIRT506004 PURG purine rich element binding protein G 2 8
MIRT506308 PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 2 6
MIRT506806 KLHL15 kelch like family member 15 2 6
MIRT507119 GOLGA8B golgin A8 family member B 2 6
MIRT507353 FAM129A family with sequence similarity 129 member A 2 6
MIRT507591 DDX3X DEAD-box helicase 3, X-linked 2 4
MIRT507674 CPEB4 cytoplasmic polyadenylation element binding protein 4 2 4
MIRT507703 CNOT2 CCR4-NOT transcription complex subunit 2 2 8
MIRT508012 BCAT1 branched chain amino acid transaminase 1 2 4
MIRT510439 ZIC5 Zic family member 5 2 6
MIRT510539 XKR7 XK related 7 2 4
MIRT510600 TPPP tubulin polymerization promoting protein 2 6
MIRT511060 NRAS NRAS proto-oncogene, GTPase 2 4
MIRT511855 GOLGA8J golgin A8 family member J 2 6
MIRT511865 GOLGA8I golgin A8 family member I, pseudogene 1 3
MIRT512570 CTDSPL CTD small phosphatase like 2 2
MIRT512708 ZNF134 zinc finger protein 134 2 6
MIRT513177 MOAP1 modulator of apoptosis 1 2 6
MIRT513783 PAWR pro-apoptotic WT1 regulator 2 6
MIRT515099 IRGQ immunity related GTPase Q 2 2
MIRT515481 INCENP inner centromere protein 2 4
MIRT517416 BMP8A bone morphogenetic protein 8a 2 2
MIRT518754 C1orf35 chromosome 1 open reading frame 35 2 2
MIRT519780 ZNF354B zinc finger protein 354B 2 4
MIRT519865 ZFP62 ZFP62 zinc finger protein 2 6
MIRT520510 TRAM2 translocation associated membrane protein 2 2 6
MIRT521068 SLC25A32 solute carrier family 25 member 32 2 6
MIRT526912 ZNF772 zinc finger protein 772 2 6
MIRT527134 GULP1 GULP, engulfment adaptor PTB domain containing 1 2 2
MIRT527867 SLC39A14 solute carrier family 39 member 14 2 2
MIRT528404 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2 2
MIRT532956 ZNF24 zinc finger protein 24 2 4
MIRT533021 ZFC3H1 zinc finger C3H1-type containing 2 4
MIRT533191 WASL Wiskott-Aldrich syndrome like 2 6
MIRT534191 SLC7A11 solute carrier family 7 member 11 2 2
MIRT534961 PTAR1 protein prenyltransferase alpha subunit repeat containing 1 2 4
MIRT536396 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT537046 GRAMD4 GRAM domain containing 4 2 2
MIRT537125 GOLGA3 golgin A3 2 4
MIRT537183 GFPT2 glutamine-fructose-6-phosphate transaminase 2 2 4
MIRT537652 ERGIC2 ERGIC and golgi 2 2 4
MIRT538632 CCSER2 coiled-coil serine rich protein 2 2 4
MIRT539231 ANP32E acidic nuclear phosphoprotein 32 family member E 2 6
MIRT540099 NPY4R neuropeptide Y receptor Y4 2 2
MIRT540998 ZNF460 zinc finger protein 460 2 4
MIRT541468 AURKA aurora kinase A 2 2
MIRT542680 SESN3 sestrin 3 2 2
MIRT542757 PRRG4 proline rich and Gla domain 4 2 2
MIRT542863 NUCKS1 nuclear casein kinase and cyclin dependent kinase substrate 1 2 2
MIRT542925 HOXC8 homeobox C8 2 2
MIRT543747 SZRD1 SUZ RNA binding domain containing 1 2 2
MIRT544404 ZSCAN12 zinc finger and SCAN domain containing 12 2 2
MIRT544583 AP5Z1 adaptor related protein complex 5 zeta 1 subunit 2 4
MIRT544662 MED19 mediator complex subunit 19 2 2
MIRT545251 GTF2E1 general transcription factor IIE subunit 1 2 2
MIRT545261 TRIM36 tripartite motif containing 36 2 4
MIRT545744 UHRF1BP1 UHRF1 binding protein 1 2 2
MIRT545999 WDR81 WD repeat domain 81 2 2
MIRT546038 VPS4B vacuolar protein sorting 4 homolog B 2 2
MIRT547170 PDZD8 PDZ domain containing 8 2 2
MIRT547273 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT547729 KIF5B kinesin family member 5B 2 2
MIRT548127 GATA6 GATA binding protein 6 2 2
MIRT548203 FNIP1 folliculin interacting protein 1 2 2
MIRT548756 CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 2 2
MIRT549641 ZNF75A zinc finger protein 75a 2 2
MIRT549684 ZNF598 zinc finger protein 598 2 2
MIRT550197 MRO maestro 2 2
MIRT550340 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT550536 MYZAP myocardial zonula adherens protein 2 2
MIRT550975 TOR4A torsin family 4 member A 2 2
MIRT551221 CIDEC cell death inducing DFFA like effector c 2 2
MIRT551355 AGBL5 ATP/GTP binding protein like 5 2 2
MIRT551571 LETM1 leucine zipper and EF-hand containing transmembrane protein 1 2 2
MIRT552277 RAB3D RAB3D, member RAS oncogene family 2 2
MIRT552661 ZADH2 zinc binding alcohol dehydrogenase domain containing 2 2 2
MIRT553081 UCK2 uridine-cytidine kinase 2 2 2
MIRT553753 TBC1D8 TBC1 domain family member 8 2 2
MIRT554030 SPCS3 signal peptidase complex subunit 3 2 2
MIRT554099 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT554155 SLX4 SLX4 structure-specific endonuclease subunit 2 2
MIRT554815 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT555522 PMEPA1 prostate transmembrane protein, androgen induced 1 2 2
MIRT555597 PIP5K1C phosphatidylinositol-4-phosphate 5-kinase type 1 gamma 2 2
MIRT555632 PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 2 4
MIRT555679 PGAM4 phosphoglycerate mutase family member 4 2 4
MIRT555827 PAX9 paired box 9 2 2
MIRT555868 PAIP1 poly(A) binding protein interacting protein 1 2 2
MIRT555939 NUP43 nucleoporin 43 2 2
MIRT555994 NFYB nuclear transcription factor Y subunit beta 2 2
MIRT556340 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT556432 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT556585 LHFPL2 LHFPL tetraspan subfamily member 2 2 4
MIRT556801 KIAA1958 KIAA1958 2 2
MIRT558047 EXOC5 exocyst complex component 5 2 2
MIRT558697 CLTA clathrin light chain A 2 2
MIRT559191 BMPR1A bone morphogenetic protein receptor type 1A 2 4
MIRT559639 AKAP10 A-kinase anchoring protein 10 2 2
MIRT559707 AEN apoptosis enhancing nuclease 2 2
MIRT560673 SRFBP1 serum response factor binding protein 1 2 2
MIRT560990 GPBP1L1 GC-rich promoter binding protein 1 like 1 2 2
MIRT562170 HOXA13 homeobox A13 2 2
MIRT562275 GNAQ G protein subunit alpha q 2 2
MIRT563624 ZNF277 zinc finger protein 277 2 2
MIRT563815 FMN1 formin 1 2 2
MIRT564096 TLR3 toll like receptor 3 2 2
MIRT565320 TMEM41A transmembrane protein 41A 2 2
MIRT565986 RNF44 ring finger protein 44 2 2
MIRT566047 REV3L REV3 like, DNA directed polymerase zeta catalytic subunit 2 2
MIRT568236 C11orf24 chromosome 11 open reading frame 24 2 2
MIRT568310 BAK1 BCL2 antagonist/killer 1 2 2
MIRT572376 ATOX1 antioxidant 1 copper chaperone 2 2
MIRT574822 CPEB3 cytoplasmic polyadenylation element binding protein 3 2 2
MIRT609212 PELP1 proline, glutamate and leucine rich protein 1 2 2
MIRT616217 RBM27 RNA binding motif protein 27 2 2
MIRT629087 FASLG Fas ligand 2 2
MIRT632124 FKBP9 FK506 binding protein 9 2 2
MIRT632576 POLQ DNA polymerase theta 2 2
MIRT634799 ENTHD1 ENTH domain containing 1 2 2
MIRT636553 ESRP1 epithelial splicing regulatory protein 1 2 2
MIRT640977 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT653875 SH2B3 SH2B adaptor protein 3 2 2
MIRT655598 OTUD7B OTU deubiquitinase 7B 2 2
MIRT659764 CCDC171 coiled-coil domain containing 171 2 2
MIRT660744 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT681037 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT682305 RBM28 RNA binding motif protein 28 2 2
MIRT682573 EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2 2
MIRT686217 ZNF267 zinc finger protein 267 2 2
MIRT687209 PLXNA3 plexin A3 2 2
MIRT690630 LAX1 lymphocyte transmembrane adaptor 1 2 2
MIRT692419 AGMAT agmatinase 2 2
MIRT694437 MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2 2
MIRT700725 PNO1 partner of NOB1 homolog 2 2
MIRT701549 NARF nuclear prelamin A recognition factor 2 2
MIRT704379 DAND5 DAN domain BMP antagonist family member 5 2 2
MIRT707935 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 2
MIRT709939 MRPS16 mitochondrial ribosomal protein S16 2 2
MIRT711371 MED7 mediator complex subunit 7 2 2
MIRT712327 PER2 period circadian clock 2 2 2
MIRT714515 SHE Src homology 2 domain containing E 2 2
MIRT715520 G2E3 G2/M-phase specific E3 ubiquitin protein ligase 2 2
MIRT724294 OSMR oncostatin M receptor 2 2
MIRT725358 MUC21 mucin 21, cell surface associated 2 2
MIRT732242 KLF4 Kruppel like factor 4 3 1
MIRT735384 SPAG5 sperm associated antigen 5 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-367 Medpor NULL NULL Microarray osteoblast-like cells line (MG-63) 18408260 2008 up-regulated
miR-367 Activin A NULL 229455 Quantitative real-time PCR Human embryonic stem (hES) cells 19885849 2010 up-regulated
miR-367 Mistletoe lectin-I NULL NULL Microarray colorectal cancer cells CLY cells 20955366 2011 down-regulated
miR-367 Doxorubicin approved 31703 Quantitative real-time PCR heart 22859947 2012 up-regulated
miR-367 Paclitaxel approved 36314 Microarray Ovarian cancer cell lines 24220856 2014 up-regulated
miR-367 Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-367 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-367-3p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-367-3p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-367-3p Siop Treatment Protocol sensitive High Nephroblastoma tissue
hsa-miR-367-3p Paclitaxel 36314 NSC125973 approved resistant High Pan-Cancer cell line (NCI-H460, NCI-H522, NCI-H322M, HOP62, A549, EKVX, MALME-3M, NCI-H226, HT-29, HCT-116, SE-620, HCT-15, HCC2998, COLO205, HS-578T, NCI/ADR-RES, OVCAR8, OVCAR4, ACHN, SN-12C, 786-O, CAKI-1, UO-31, TK-10, A498, SK-MEL-28, UACC-257, M14, UACC-62, SK
hsa-miR-367-3p Doxorubicin 31703 NSC123127 approved sensitive High Hepatocellular Carcinoma tissue and cell line (HepG2)
hsa-miR-367-3p Mitoxantrone 4212 NSC279836 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-367-3p Sorafenib 216239 NSC747971 approved sensitive Low Hepatocellular Carcinoma cell line (SKhep1, HA22T)
hsa-miR-367-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-367-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM16)
hsa-miR-367-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-367-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-367-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-367-3p Cisplatin 5460033 NSC119875 approved resistant cell line (IGROV-1)
hsa-miR-367-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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