pre-miRNA Information
pre-miRNA hsa-mir-4747   
Genomic Coordinates chr19: 4932687 - 4932740
Description Homo sapiens miR-4747 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4747-5p
Sequence 1| AGGGAAGGAGGCUUGGUCUUAG |22
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs560927363 4 dbSNP
rs1471226927 10 dbSNP
rs763137545 12 dbSNP
rs767337154 15 dbSNP
rs775298039 16 dbSNP
rs760472311 19 dbSNP
rs1207950315 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol WNT7B   
Synonyms -
Description Wnt family member 7B
Transcript NM_058238   
Expression
Putative miRNA Targets on WNT7B
3'UTR of WNT7B
(miRNA target sites are highlighted)
>WNT7B|NM_058238|3'UTR
   1 GGCCAGGCCCGGAGGCGGCCGCGGGCACCCTGGAACCCGGCGGCATTTTGCACATCCACTCCTCACCTTCCCTGCCTTGG
  81 TGCTGCCAGCAGCAGACATAGACGGGTGCAGAAGCGGGGAGCTCCAGGTGCAGGAGGGCACCGGCCGGGGCCCACGCCCT
 161 CTGCCCGCCTCCCTGGGGCTCCTTCCTGCCACCTCCTCCCATCACCTCCTGCGGCAGAACAGCACCCGTGACCCACCCAG
 241 AGAGCAAGGCCAGGGGTCTTGGTGCTCCCCGACGGGGCCCGGCAAGTTCTCTTTCTTCTCTCTGGGAAAATGAACGTCCA
 321 GGACACACCTGTATCCCAGAGAGCAAAGTGATGAGGAGACTGAGCGTCCCCAGCCCCACCTGGCGGCATGGACACAGAAA
 401 AGCTACGCCGGCTGGCCTCTCCAGACCAGTTCCCAGGCTGGGTCTGCCGCTGGGCCCTGGGGCGGTGGGGACAGATGTTG
 481 ACACAAATTATTTATGTTTTCTTAGTATCAGAAGAGGATTCTCGGCACTAACACATAGCCAGTCCTAACTCCGTACTCTG
 561 TGTCAGCCCATCCCCTAGACACCCTCTGTTTCCTTTCCCGGCCCCACCTGGCCGGCCCTCTGCCCCTGCAGAGCTGAGGC
 641 AGCCTGGGGTTGATGGGGACCACGCGGTGCCTGCAGGTCCTAGAAGTGAGCTGGGCAGGGGCTCTTCAGACCACACAGCC
 721 CTGACCGGGCCTTGGAGGAGAGCCATGGACAGGCTCCTCCATGCCGTCTTTCCTTCTTTTGAAAATCCTATCAATGGCTG
 801 GGCGCGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGACCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTCGAGAC
 881 CAGCCTGGCCAACGTGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGCGTGCACCTGTAATC
 961 CCAGCTACTCAGGAGGCTGAGACAGGACACTTGCTTGAACCCGGGAGGTGGAGGTTGCAATGAGCCAAGATTGTGCCACT
1041 GTATTCCAACTTGGGTGACAGAGCACGACTCTGTCTCAAAAAAAGAAAAGAAAATAATATCAAGCAAATCAAAATATCAC
1121 CCACGTCAGGTTCCAGGAGTCCTTCGTTCCCTCCCTCATCCTGTCACCCTCCCGGCCTGGCACCTCCAGTTTACAGAGAC
1201 CCCCTTCCCCCTGGAGCCAGCCTGACCCCTGGGACAGTGCTGCCGCGGGGGTCAGGCAGGTGGTGAGTGGTCAGGGATGT
1281 TTGTCCCACTTGACAGATGGGAACTCTGAGGCCCAGAGTGGCACAAGGACCTACCAGAGACCCTGCAGCTGTGACTGGAG
1361 GCTTCCACCTTTCTCCTGCCCAGCCTGGGGCTCTGGACCTGGGAGAACACATCAGGATGCCCGGGGTGGCAGTAGGTAGC
1441 TCCCATGCCTTGAGGCACTTGGCTGCTCCCTCCACCCCCTGACAGCCTCATTGGGGCCTGCACTCCCCTCGGTGCCTTTG
1521 AGGCTTCGCCTAGCCCTGTCCTGGTCCTTTTACCCTGACCCCAGTGCTGAGAAAATCTGGATCCAGAGCTGGACATGTCC
1601 TTTCTGGATGCTCCCACCCCTGTCTCTGAGGAGCATGAGTGACAGAGGGAGGAACTTGTCCGAGGCCAGAGAGGATGGTC
1681 TGCAGCTGGCTCCTGGTGCACCCCCACTGCCCACGGCCTGGCCCCCATTTAGGGTGTGTTCTCTTGGAAGCCCGTAGGAA
1761 TGTGTTCTTGAGCAGCCGACAAGCCAAGGGCCTGGGCTCAGCCTGGGGCAAGTGGGTCCCTCCTGGGCTCTGGCCCTGTG
1841 GTCCAGCCCATGTGCCTCTAACCATGCCTGGACGCTCTGAGTCTCCGGGCCACCGTGAATGCCCCACCCTCAGCCTGGCC
1921 CCATCCCCTTACCTTCCCCAAGTCCCAGAACACACCTGAGTCCATAGGCCCGGCAGCCTCTGCAAGGAACCTGGTTAACT
2001 TATGTTGTTATATAGCGTCGAAATGTCTATAGTGTCTTTAAATTATTGTGACCTACACTGGGTACCGGAGAGGGGGATGG
2081 CTGCGGCCCCCATCCCTCATCCCCCATCCCATCCCATCCCTCATCTCATCCCTCATCCCATCCCCCATCCCATCCCTGAC
2161 CCCATCCCCCATCCCATCCCTCATCCCTATTCCCCATACCCACCCCCCATCCCATCCCCCATCTCCCGAACCAGGCTCCT
2241 CCTGCTTCAACAGACCCTTGGGGCCCCTGATGCCACCGAGACACTCGCACTGTCCCTTGGCTGCCGGGCACCCCACTGAG
2321 CCCCTGCCCACCCCAAAGTCTGCCAGCAACAGGCCCTTTGCCTGGGTGAGACGGGGGTCAGGGTGGCCCAGATGGGGGTG
2401 ATGGCGACCAAGGTGCTGCGTCCCCACCCTTCTGACGGCAGCCTCCCCTGGAGGGGAGTGCTCGGCCCAATAAAAGCTGG
2481 AATCGGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gauucUGGUUC-GGAGGAAGGGa 5'
               || :|| || ||||||| 
Target 5' agtttACAGAGACCCCCTTCCCc 3'
1188 - 1210 157.00 -17.40
2
miRNA  3' gauucuGGUUCGGA--GGAAGGGa 5'
                |||  |||  ||||||| 
Target 5' gcacatCCACTCCTCACCTTCCCt 3'
50 - 73 154.00 -19.00
3
miRNA  3' gauUCUGGUUCGG---A-GGAAGGGa 5'
             :| || | ||   | ||||||| 
Target 5' cctGGCCCCATCCCCTTACCTTCCCc 3'
1914 - 1939 147.00 -19.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN27005117 16 COSMIC
COSN30601580 21 COSMIC
COSN30480220 28 COSMIC
COSN30483108 35 COSMIC
COSN30459660 39 COSMIC
COSN30481472 39 COSMIC
COSN30157142 53 COSMIC
COSN30481766 64 COSMIC
COSN30447963 70 COSMIC
COSN30508660 76 COSMIC
COSN26548254 90 COSMIC
COSN1263016 806 COSMIC
COSN20179839 815 COSMIC
COSN8997531 892 COSMIC
COSN17601815 1477 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs906009740 1 dbSNP
rs965288751 2 dbSNP
rs373580692 3 dbSNP
rs773564586 6 dbSNP
rs1202556712 7 dbSNP
rs111982331 10 dbSNP
rs747793574 11 dbSNP
rs373115429 15 dbSNP
rs754534050 16 dbSNP
rs370224093 17 dbSNP
rs1351149735 19 dbSNP
rs895551467 20 dbSNP
rs780036850 21 dbSNP
rs758319832 22 dbSNP
rs750199942 23 dbSNP
rs372846592 24 dbSNP
rs756323048 25 dbSNP
rs1274094047 32 dbSNP
rs778823832 32 dbSNP
rs753011143 33 dbSNP
rs754870032 36 dbSNP
rs767814061 38 dbSNP
rs528108376 39 dbSNP
rs774558955 41 dbSNP
rs369203607 42 dbSNP
rs1463007376 43 dbSNP
rs1244477149 44 dbSNP
rs368443461 45 dbSNP
rs371939748 46 dbSNP
rs943260528 56 dbSNP
rs1410849247 65 dbSNP
rs1398380763 66 dbSNP
rs542336315 83 dbSNP
rs778450689 86 dbSNP
rs11544454 99 dbSNP
rs556884218 100 dbSNP
rs987704685 101 dbSNP
rs1257932048 103 dbSNP
rs543640693 104 dbSNP
rs577855916 105 dbSNP
rs1235591822 108 dbSNP
rs948241020 115 dbSNP
rs893946292 116 dbSNP
rs1033281420 117 dbSNP
rs375863236 123 dbSNP
rs1286459426 130 dbSNP
rs750260919 136 dbSNP
rs979062061 142 dbSNP
rs73457143 143 dbSNP
rs371230475 146 dbSNP
rs1034537993 147 dbSNP
rs539002731 155 dbSNP
rs1404109544 156 dbSNP
rs1296049546 161 dbSNP
rs1408032250 164 dbSNP
rs1014799240 166 dbSNP
rs113363630 167 dbSNP
rs1374246109 174 dbSNP
rs976773875 177 dbSNP
rs1025989455 178 dbSNP
rs943987038 191 dbSNP
rs911145153 200 dbSNP
rs985352483 201 dbSNP
rs1170017653 205 dbSNP
rs952538033 206 dbSNP
rs115577190 212 dbSNP
rs972933721 213 dbSNP
rs1351471999 217 dbSNP
rs1233741675 220 dbSNP
rs1187489993 222 dbSNP
rs555867960 227 dbSNP
rs1035811803 228 dbSNP
rs1258752727 237 dbSNP
rs1435905693 238 dbSNP
rs553460765 242 dbSNP
rs536753503 244 dbSNP
rs1482884447 248 dbSNP
rs1233159292 253 dbSNP
rs969671387 256 dbSNP
rs9723264 257 dbSNP
rs1393747929 258 dbSNP
rs1012442265 259 dbSNP
rs1004722080 267 dbSNP
rs550891875 270 dbSNP
rs761534003 271 dbSNP
rs1264739461 273 dbSNP
rs111885193 274 dbSNP
rs1331121673 278 dbSNP
rs1336649623 278 dbSNP
rs925973424 280 dbSNP
rs370301678 281 dbSNP
rs1234891403 292 dbSNP
rs902606014 296 dbSNP
rs1272178236 298 dbSNP
rs762556339 298 dbSNP
rs571830654 300 dbSNP
rs1467764313 302 dbSNP
rs944039566 315 dbSNP
rs1026419993 320 dbSNP
rs911197689 331 dbSNP
rs1422162949 332 dbSNP
rs1389428466 361 dbSNP
rs993234762 365 dbSNP
rs777228528 366 dbSNP
rs1458907797 369 dbSNP
rs1370547058 372 dbSNP
rs73457141 376 dbSNP
rs919787964 384 dbSNP
rs1252739817 385 dbSNP
rs1007600278 389 dbSNP
rs1294765805 399 dbSNP
rs889048382 404 dbSNP
rs778822439 406 dbSNP
rs372979871 407 dbSNP
rs1204112381 409 dbSNP
rs558926211 410 dbSNP
rs928419935 417 dbSNP
rs1195724129 423 dbSNP
rs934770779 427 dbSNP
rs1358469029 435 dbSNP
rs1258898501 436 dbSNP
rs548624495 437 dbSNP
rs969722439 439 dbSNP
rs1329636685 441 dbSNP
rs1022570709 442 dbSNP
rs1288378444 449 dbSNP
rs9330786 451 dbSNP
rs1383885835 452 dbSNP
rs1329980843 456 dbSNP
rs1318943395 463 dbSNP
rs563441556 463 dbSNP
rs1323708730 464 dbSNP
rs1294745744 470 dbSNP
rs1335085252 472 dbSNP
rs958309541 473 dbSNP
rs993508372 477 dbSNP
rs960266239 491 dbSNP
rs1207383886 495 dbSNP
rs1393425632 516 dbSNP
rs1485546454 517 dbSNP
rs1186259144 518 dbSNP
rs1032974939 523 dbSNP
rs999702376 524 dbSNP
rs1232474400 528 dbSNP
rs1456999143 536 dbSNP
rs773601548 539 dbSNP
rs963102549 541 dbSNP
rs1041164821 545 dbSNP
rs543229186 552 dbSNP
rs748362507 553 dbSNP
rs67976848 558 dbSNP
rs751649991 560 dbSNP
rs889830129 560 dbSNP
rs1029980500 561 dbSNP
rs1318182607 566 dbSNP
rs1239219296 572 dbSNP
rs1287285205 574 dbSNP
rs9330785 577 dbSNP
rs541338652 578 dbSNP
rs1176815757 582 dbSNP
rs1248759365 585 dbSNP
rs764109966 585 dbSNP
rs1000666253 587 dbSNP
rs1208069208 588 dbSNP
rs75330741 599 dbSNP
rs553393767 600 dbSNP
rs779819590 604 dbSNP
rs939881892 606 dbSNP
rs1296087167 609 dbSNP
rs536692596 613 dbSNP
rs1446803868 614 dbSNP
rs574029409 614 dbSNP
rs1302091439 619 dbSNP
rs1370855476 621 dbSNP
rs915923413 621 dbSNP
rs1275075432 625 dbSNP
rs981182144 632 dbSNP
rs1057123481 633 dbSNP
rs1313137401 638 dbSNP
rs1204351446 639 dbSNP
rs969778104 645 dbSNP
rs1234705903 646 dbSNP
rs915614663 652 dbSNP
rs756050140 653 dbSNP
rs989785179 655 dbSNP
rs957223138 662 dbSNP
rs1199301343 663 dbSNP
rs1032613524 664 dbSNP
rs972216198 665 dbSNP
rs557462403 666 dbSNP
rs908980233 682 dbSNP
rs1427632520 691 dbSNP
rs77830872 700 dbSNP
rs1355870611 702 dbSNP
rs953144949 705 dbSNP
rs750378223 726 dbSNP
rs571832064 727 dbSNP
rs889882172 737 dbSNP
rs1277119050 740 dbSNP
rs1173399843 741 dbSNP
rs1368926499 743 dbSNP
rs956615914 747 dbSNP
rs1030893639 758 dbSNP
rs551740454 760 dbSNP
rs865873716 762 dbSNP
rs150147568 764 dbSNP
rs186381255 765 dbSNP
rs767332055 766 dbSNP
rs894556184 776 dbSNP
rs1485515262 788 dbSNP
rs939912073 793 dbSNP
rs907086712 796 dbSNP
rs1184518919 798 dbSNP
rs1421350833 802 dbSNP
rs1201466176 803 dbSNP
rs548564050 804 dbSNP
rs948525013 805 dbSNP
rs528883829 806 dbSNP
rs1201855345 807 dbSNP
rs534025552 810 dbSNP
rs919525234 811 dbSNP
rs915667020 815 dbSNP
rs61670056 816 dbSNP
rs942279171 836 dbSNP
rs1292903747 838 dbSNP
rs935693876 843 dbSNP
rs1333041238 844 dbSNP
rs1230080588 849 dbSNP
rs1290729417 850 dbSNP
rs924260585 851 dbSNP
rs1213497259 855 dbSNP
rs1250014765 862 dbSNP
rs986309260 864 dbSNP
rs1488455152 867 dbSNP
rs543830334 872 dbSNP
rs549871443 875 dbSNP
rs967355491 876 dbSNP
rs1398468767 886 dbSNP
rs975758322 889 dbSNP
rs1019843490 893 dbSNP
rs1353764349 894 dbSNP
rs1400980158 894 dbSNP
rs1450419667 899 dbSNP
rs956336159 904 dbSNP
rs1416432150 906 dbSNP
rs1222145003 907 dbSNP
rs777118340 909 dbSNP
rs1354392701 913 dbSNP
rs1209858089 914 dbSNP
rs1277967429 921 dbSNP
rs1443955249 926 dbSNP
rs573564074 929 dbSNP
rs986968538 932 dbSNP
rs979370407 936 dbSNP
rs532938949 938 dbSNP
rs954168770 939 dbSNP
rs564318224 941 dbSNP
rs967981802 944 dbSNP
rs995981846 946 dbSNP
rs148064407 947 dbSNP
rs1173597656 956 dbSNP
rs1373976346 966 dbSNP
rs1016009955 970 dbSNP
rs1004169025 975 dbSNP
rs572368836 986 dbSNP
rs1354233941 1000 dbSNP
rs1440093395 1001 dbSNP
rs1391871664 1002 dbSNP
rs561992530 1003 dbSNP
rs894561540 1013 dbSNP
rs948573872 1014 dbSNP
rs1233419411 1015 dbSNP
rs894284357 1017 dbSNP
rs1054241278 1031 dbSNP
rs543029404 1033 dbSNP
rs573993020 1034 dbSNP
rs369551176 1035 dbSNP
rs942311467 1050 dbSNP
rs28681555 1051 dbSNP
rs924333934 1057 dbSNP
rs977498624 1061 dbSNP
rs944315546 1063 dbSNP
rs182309829 1066 dbSNP
rs190236470 1067 dbSNP
rs1479205998 1071 dbSNP
rs775032386 1073 dbSNP
rs1343709960 1077 dbSNP
rs975853189 1078 dbSNP
rs921412451 1084 dbSNP
rs1277347708 1095 dbSNP
rs935052649 1095 dbSNP
rs974223542 1095 dbSNP
rs963111592 1099 dbSNP
rs1323806134 1104 dbSNP
rs557918991 1110 dbSNP
rs114190593 1114 dbSNP
rs1233679435 1121 dbSNP
rs566008279 1124 dbSNP
rs1378878430 1125 dbSNP
rs1015646163 1133 dbSNP
rs1285219330 1140 dbSNP
rs1004625593 1141 dbSNP
rs185363951 1145 dbSNP
rs114771506 1146 dbSNP
rs1211348743 1160 dbSNP
rs1307669272 1161 dbSNP
rs1265866254 1163 dbSNP
rs569637266 1173 dbSNP
rs549571609 1174 dbSNP
rs1372823362 1177 dbSNP
rs1034800371 1198 dbSNP
rs1173012929 1202 dbSNP
rs1002942135 1203 dbSNP
rs764409313 1205 dbSNP
rs1162561732 1206 dbSNP
rs1054694701 1209 dbSNP
rs1162941143 1211 dbSNP
rs1392755870 1217 dbSNP
rs566630955 1221 dbSNP
rs1317586692 1222 dbSNP
rs1324412182 1226 dbSNP
rs897907062 1227 dbSNP
rs1014919112 1229 dbSNP
rs1333773982 1230 dbSNP
rs1404742052 1242 dbSNP
rs1006183819 1244 dbSNP
rs902933689 1245 dbSNP
rs73175048 1246 dbSNP
rs757047118 1247 dbSNP
rs1250550176 1251 dbSNP
rs932207022 1252 dbSNP
rs547595137 1255 dbSNP
rs1182489645 1256 dbSNP
rs1185728704 1263 dbSNP
rs1370219509 1264 dbSNP
rs1458486765 1267 dbSNP
rs1483734690 1268 dbSNP
rs1157858937 1269 dbSNP
rs1382782310 1278 dbSNP
rs911544619 1284 dbSNP
rs1298631728 1287 dbSNP
rs1244529283 1288 dbSNP
rs1354393985 1292 dbSNP
rs1412491254 1293 dbSNP
rs1051368764 1305 dbSNP
rs1340483581 1306 dbSNP
rs1237790891 1312 dbSNP
rs539636205 1313 dbSNP
rs771560336 1316 dbSNP
rs1040554053 1320 dbSNP
rs527518261 1327 dbSNP
rs561928653 1334 dbSNP
rs1291220950 1342 dbSNP
rs1230328104 1346 dbSNP
rs923644650 1348 dbSNP
rs78936816 1351 dbSNP
rs1424468822 1352 dbSNP
rs946375859 1359 dbSNP
rs1229284973 1361 dbSNP
rs1441509847 1365 dbSNP
rs974657126 1366 dbSNP
rs1374569225 1378 dbSNP
rs1464364963 1379 dbSNP
rs192805787 1383 dbSNP
rs1390295062 1384 dbSNP
rs1304286551 1390 dbSNP
rs1291916447 1403 dbSNP
rs1378517683 1405 dbSNP
rs1435667318 1408 dbSNP
rs1310649344 1410 dbSNP
rs1350342014 1414 dbSNP
rs1347526883 1415 dbSNP
rs908641053 1420 dbSNP
rs571818412 1422 dbSNP
rs971400111 1423 dbSNP
rs1455408045 1424 dbSNP
rs927835716 1425 dbSNP
rs972538891 1427 dbSNP
rs1024243053 1430 dbSNP
rs1469837498 1442 dbSNP
rs1012826365 1445 dbSNP
rs1236386127 1447 dbSNP
rs958621745 1448 dbSNP
rs1459159897 1450 dbSNP
rs962105239 1450 dbSNP
rs1032888992 1451 dbSNP
rs1006651400 1452 dbSNP
rs748521919 1459 dbSNP
rs550277257 1466 dbSNP
rs1050984199 1472 dbSNP
rs902987043 1475 dbSNP
rs73175047 1477 dbSNP
rs141543789 1478 dbSNP
rs375038778 1479 dbSNP
rs1190057859 1481 dbSNP
rs1446889401 1485 dbSNP
rs578046219 1486 dbSNP
rs376701156 1491 dbSNP
rs1367589422 1492 dbSNP
rs1050079943 1502 dbSNP
rs567620073 1503 dbSNP
rs572329506 1506 dbSNP
rs549434922 1510 dbSNP
rs941541010 1511 dbSNP
rs1199419129 1512 dbSNP
rs946442155 1515 dbSNP
rs1487490488 1516 dbSNP
rs536156921 1527 dbSNP
rs1229229784 1528 dbSNP
rs570294261 1530 dbSNP
rs556124340 1535 dbSNP
rs1212837654 1538 dbSNP
rs1218673916 1542 dbSNP
rs79828342 1546 dbSNP
rs1465679638 1549 dbSNP
rs1276512338 1553 dbSNP
rs1332474247 1559 dbSNP
rs1434889300 1561 dbSNP
rs1295824608 1569 dbSNP
rs1368674262 1591 dbSNP
rs917283307 1594 dbSNP
rs570548774 1595 dbSNP
rs1320337920 1598 dbSNP
rs547532882 1606 dbSNP
rs961170799 1611 dbSNP
rs1272587254 1613 dbSNP
rs1387625909 1618 dbSNP
rs909687732 1620 dbSNP
rs984919474 1621 dbSNP
rs958709185 1630 dbSNP
rs368125342 1631 dbSNP
rs952217792 1633 dbSNP
rs1186816872 1635 dbSNP
rs188844737 1636 dbSNP
rs996541443 1640 dbSNP
rs548310195 1642 dbSNP
rs184162816 1647 dbSNP
rs1426708203 1648 dbSNP
rs966290688 1661 dbSNP
rs1019178542 1662 dbSNP
rs999714174 1663 dbSNP
rs75848132 1664 dbSNP
rs1376982822 1673 dbSNP
rs1349504347 1674 dbSNP
rs1230163972 1677 dbSNP
rs1487068335 1688 dbSNP
rs1352961163 1689 dbSNP
rs1044272202 1692 dbSNP
rs1008684640 1693 dbSNP
rs1287840556 1698 dbSNP
rs755910829 1702 dbSNP
rs1209731261 1707 dbSNP
rs531622291 1714 dbSNP
rs191549873 1715 dbSNP
rs1181992625 1717 dbSNP
rs1028709175 1722 dbSNP
rs1415123478 1723 dbSNP
rs1439583976 1724 dbSNP
rs1157411644 1727 dbSNP
rs1226084161 1733 dbSNP
rs894887606 1736 dbSNP
rs1357702928 1737 dbSNP
rs1450271531 1738 dbSNP
rs1284894791 1742 dbSNP
rs1376291856 1743 dbSNP
rs1054803676 1750 dbSNP
rs186742442 1753 dbSNP
rs1298264460 1754 dbSNP
rs1383651980 1762 dbSNP
rs1376738909 1763 dbSNP
rs898805975 1764 dbSNP
rs1210427398 1776 dbSNP
rs1039054638 1777 dbSNP
rs1360375129 1778 dbSNP
rs941604197 1779 dbSNP
rs887314114 1788 dbSNP
rs1047211540 1791 dbSNP
rs1428542079 1794 dbSNP
rs1382772563 1797 dbSNP
rs984358966 1797 dbSNP
rs1390035861 1800 dbSNP
rs113866700 1804 dbSNP
rs917348767 1809 dbSNP
rs991504013 1815 dbSNP
rs1333275744 1822 dbSNP
rs765867790 1824 dbSNP
rs1232226956 1826 dbSNP
rs1254573843 1827 dbSNP
rs564206157 1830 dbSNP
rs1181487546 1846 dbSNP
rs112416708 1857 dbSNP
rs925955937 1860 dbSNP
rs1203042960 1863 dbSNP
rs1341567869 1865 dbSNP
rs979124022 1871 dbSNP
rs11544453 1873 dbSNP
rs1200046089 1874 dbSNP
rs978369014 1875 dbSNP
rs1438941583 1877 dbSNP
rs1020177808 1883 dbSNP
rs555532900 1884 dbSNP
rs967357051 1886 dbSNP
rs1022502698 1887 dbSNP
rs1173310776 1888 dbSNP
rs1311812130 1893 dbSNP
rs987306508 1894 dbSNP
rs542105873 1895 dbSNP
rs576656136 1903 dbSNP
rs1400900424 1911 dbSNP
rs1386100058 1912 dbSNP
rs1321524783 1913 dbSNP
rs1028761201 1916 dbSNP
rs372229104 1922 dbSNP
rs995929056 1925 dbSNP
rs556620582 1926 dbSNP
rs75343830 1931 dbSNP
rs1219905175 1933 dbSNP
rs939977729 1935 dbSNP
rs761847840 1936 dbSNP
rs1006252955 1939 dbSNP
rs570483209 1945 dbSNP
rs1047278286 1954 dbSNP
rs1164443977 1955 dbSNP
rs1424774333 1965 dbSNP
rs758099832 1968 dbSNP
rs950230618 1971 dbSNP
rs895973102 1972 dbSNP
rs553854423 1979 dbSNP
rs1373662707 1987 dbSNP
rs1457477802 1991 dbSNP
rs28454273 1995 dbSNP
rs1392867866 1999 dbSNP
rs922057411 2002 dbSNP
rs1297400359 2003 dbSNP
rs1338186419 2011 dbSNP
rs1401407939 2016 dbSNP
rs533880160 2017 dbSNP
rs944760965 2019 dbSNP
rs911930585 2020 dbSNP
rs925979869 2023 dbSNP
rs1285703273 2026 dbSNP
rs1264798104 2030 dbSNP
rs1245171520 2032 dbSNP
rs1218990092 2037 dbSNP
rs765274323 2051 dbSNP
rs966991401 2058 dbSNP
rs1022937572 2060 dbSNP
rs1043068797 2064 dbSNP
rs867979885 2066 dbSNP
rs946000920 2067 dbSNP
rs1033794259 2072 dbSNP
rs1358324579 2072 dbSNP
rs1401128285 2075 dbSNP
rs913171907 2084 dbSNP
rs987358584 2085 dbSNP
rs1247285883 2087 dbSNP
rs1015215490 2089 dbSNP
rs182436724 2095 dbSNP
rs888383134 2096 dbSNP
rs1048764358 2097 dbSNP
rs1483071180 2097 dbSNP
rs1258294535 2104 dbSNP
rs996758780 2104 dbSNP
rs1461836225 2106 dbSNP
rs1177857011 2108 dbSNP
rs1378477063 2109 dbSNP
rs1420520882 2110 dbSNP
rs776586705 2111 dbSNP
rs899693575 2111 dbSNP
rs112457027 2114 dbSNP
rs1173989526 2114 dbSNP
rs1157186752 2116 dbSNP
rs1472418578 2117 dbSNP
rs1308108887 2121 dbSNP
rs1311998441 2121 dbSNP
rs137871195 2121 dbSNP
rs879191712 2121 dbSNP
rs537672951 2122 dbSNP
rs1198153627 2123 dbSNP
rs1439133726 2123 dbSNP
rs944811774 2123 dbSNP
rs112599486 2126 dbSNP
rs1236263976 2126 dbSNP
rs887575189 2126 dbSNP
rs1183995850 2128 dbSNP
rs1431525188 2129 dbSNP
rs1266345794 2133 dbSNP
rs562275592 2133 dbSNP
rs1177789424 2134 dbSNP
rs1429631720 2135 dbSNP
rs1464632118 2136 dbSNP
rs1049188646 2138 dbSNP
rs1401886180 2138 dbSNP
rs1463937870 2138 dbSNP
rs1266526153 2140 dbSNP
rs1367259200 2143 dbSNP
rs1303659468 2145 dbSNP
rs1385518255 2145 dbSNP
rs937544371 2145 dbSNP
rs1210400707 2146 dbSNP
rs1469633033 2148 dbSNP
rs927053968 2150 dbSNP
rs1264865499 2155 dbSNP
rs200390203 2157 dbSNP
rs764762531 2157 dbSNP
rs1269121532 2158 dbSNP
rs146348184 2158 dbSNP
rs193275266 2160 dbSNP
rs988699815 2163 dbSNP
rs1329343816 2164 dbSNP
rs1428600196 2164 dbSNP
rs1171725653 2165 dbSNP
rs957264343 2166 dbSNP
rs1280943796 2168 dbSNP
rs1366612895 2169 dbSNP
rs149177997 2169 dbSNP
rs915515499 2169 dbSNP
rs1230378936 2170 dbSNP
rs1215303720 2176 dbSNP
rs1311894499 2177 dbSNP
rs1330038146 2182 dbSNP
rs1301146158 2188 dbSNP
rs990167276 2193 dbSNP
rs1006722768 2196 dbSNP
rs1442341899 2198 dbSNP
rs1213923288 2202 dbSNP
rs1397122941 2203 dbSNP
rs1475446859 2203 dbSNP
rs959640722 2204 dbSNP
rs1422540165 2208 dbSNP
rs1319038285 2209 dbSNP
rs1386189297 2209 dbSNP
rs1296570666 2214 dbSNP
rs1419483869 2214 dbSNP
rs1347226953 2216 dbSNP
rs1431533986 2216 dbSNP
rs1302297611 2218 dbSNP
rs1457047617 2219 dbSNP
rs954556576 2220 dbSNP
rs1454818168 2223 dbSNP
rs1248011463 2225 dbSNP
rs113343186 2228 dbSNP
rs1160536651 2236 dbSNP
rs371742816 2238 dbSNP
rs547428158 2239 dbSNP
rs963153500 2244 dbSNP
rs1199473110 2251 dbSNP
rs1483954264 2254 dbSNP
rs1455585990 2262 dbSNP
rs1016394651 2265 dbSNP
rs1439449386 2275 dbSNP
rs1187636745 2276 dbSNP
rs1465204003 2277 dbSNP
rs879566254 2278 dbSNP
rs1175647085 2282 dbSNP
rs950356898 2286 dbSNP
rs1025879894 2287 dbSNP
rs1256131996 2301 dbSNP
rs1376128360 2303 dbSNP
rs1444266206 2304 dbSNP
rs1014439286 2305 dbSNP
rs896027019 2306 dbSNP
rs1235658264 2308 dbSNP
rs1055959518 2309 dbSNP
rs1002074923 2310 dbSNP
rs904607543 2311 dbSNP
rs78437334 2312 dbSNP
rs1296061035 2313 dbSNP
rs1203810608 2315 dbSNP
rs946083132 2317 dbSNP
rs1026639764 2318 dbSNP
rs561877273 2322 dbSNP
rs899748856 2324 dbSNP
rs1470721920 2327 dbSNP
rs1190827519 2342 dbSNP
rs1423398960 2350 dbSNP
rs1470983028 2354 dbSNP
rs1177291360 2356 dbSNP
rs1320510016 2357 dbSNP
rs1051705462 2359 dbSNP
rs542396254 2360 dbSNP
rs921798812 2365 dbSNP
rs1413040336 2372 dbSNP
rs974612439 2373 dbSNP
rs1040902260 2377 dbSNP
rs1336058394 2378 dbSNP
rs1435579102 2379 dbSNP
rs963506249 2380 dbSNP
rs576578755 2381 dbSNP
rs1347053991 2382 dbSNP
rs1223784155 2383 dbSNP
rs1256816445 2391 dbSNP
rs983591806 2393 dbSNP
rs1388197227 2395 dbSNP
rs1194520157 2398 dbSNP
rs1275805035 2399 dbSNP
rs1438741691 2404 dbSNP
rs56686476 2405 dbSNP
rs1024591675 2406 dbSNP
rs890559550 2407 dbSNP
rs1243679536 2408 dbSNP
rs1014493857 2412 dbSNP
rs1042474283 2413 dbSNP
rs1422936384 2417 dbSNP
rs960287583 2418 dbSNP
rs1034974643 2419 dbSNP
rs915260591 2420 dbSNP
rs1001730499 2424 dbSNP
rs1441554010 2426 dbSNP
rs535938492 2434 dbSNP
rs1404520434 2435 dbSNP
rs1212332623 2436 dbSNP
rs1043176652 2437 dbSNP
rs1010307071 2439 dbSNP
rs1337774205 2441 dbSNP
rs1229055121 2446 dbSNP
rs1339476849 2447 dbSNP
rs1273058355 2453 dbSNP
rs891843524 2463 dbSNP
rs771362848 2464 dbSNP
rs926843394 2468 dbSNP
rs982257497 2469 dbSNP
rs970844682 2470 dbSNP
rs1195478480 2473 dbSNP
rs1051760304 2474 dbSNP
rs761141806 2475 dbSNP
rs933275639 2479 dbSNP
rs900424256 2482 dbSNP
rs1161610481 2484 dbSNP
rs540163994 2485 dbSNP
rs1297189484 2488 dbSNP
rs952487935 2491 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gauucuGGUUCGGA--GGAAGGGa 5'
                |||  |||  ||||||| 
Target 5' gcacauCCACUCCUCACCUUCCCu 3'
17 - 40
2
miRNA  3' gauucUGGUUCGGAGGAAGGga 5'
               ||| :||  | ||::  
Target 5' ----aACCCGGCGGCAUUUUgc 3'
1 - 18
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177599. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_1 PAR-CLIP data was present in ERX177623. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_4_1 PAR-CLIP data was present in ERX177629. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_4_7 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000339464.4 | 3UTR | AACCCGGCGGCAUUUUGCACAUCCACUCCUCACCUUCCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
215 hsa-miR-4747-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT061689 BTG2 BTG anti-proliferation factor 2 2 2
MIRT062834 BCL7A BCL tumor suppressor 7A 2 2
MIRT079371 CCDC137 coiled-coil domain containing 137 2 2
MIRT081190 MIDN midnolin 2 4
MIRT081724 ZNF507 zinc finger protein 507 2 2
MIRT110565 ZMYND11 zinc finger MYND-type containing 11 2 2
MIRT133724 SKI SKI proto-oncogene 2 4
MIRT146689 MINK1 misshapen like kinase 1 2 2
MIRT150676 SLC27A1 solute carrier family 27 member 1 2 2
MIRT159196 NRBP1 nuclear receptor binding protein 1 2 2
MIRT180865 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 2
MIRT190659 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT196111 MPRIP myosin phosphatase Rho interacting protein 2 2
MIRT232390 SP1 Sp1 transcription factor 2 2
MIRT331070 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 4
MIRT338632 SHMT2 serine hydroxymethyltransferase 2 2 2
MIRT407441 CTDSP1 CTD small phosphatase 1 2 2
MIRT444276 NKX6-1 NK6 homeobox 1 2 2
MIRT444834 PDE6D phosphodiesterase 6D 2 2
MIRT445452 EXT1 exostosin glycosyltransferase 1 2 2
MIRT445644 NPY4R neuropeptide Y receptor Y4 2 2
MIRT446157 RPL12 ribosomal protein L12 2 2
MIRT446608 HIP1 huntingtin interacting protein 1 2 2
MIRT447108 CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2 2
MIRT449314 MRO maestro 2 2
MIRT450305 DRAXIN dorsal inhibitory axon guidance protein 2 2
MIRT451245 ZNF444 zinc finger protein 444 2 2
MIRT451714 OLR1 oxidized low density lipoprotein receptor 1 2 2
MIRT451908 ILK integrin linked kinase 2 2
MIRT452183 KIAA1456 KIAA1456 2 2
MIRT452610 REPIN1 replication initiator 1 2 2
MIRT453422 GLG1 golgi glycoprotein 1 2 2
MIRT454006 ALKBH5 alkB homolog 5, RNA demethylase 2 2
MIRT455072 ARHGAP39 Rho GTPase activating protein 39 2 2
MIRT455319 TTLL9 tubulin tyrosine ligase like 9 2 2
MIRT455357 KDM5C lysine demethylase 5C 2 2
MIRT455589 TAF12 TATA-box binding protein associated factor 12 2 2
MIRT455711 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2 2
MIRT455860 TMEM254 transmembrane protein 254 2 2
MIRT455919 RAPGEF1 Rap guanine nucleotide exchange factor 1 2 2
MIRT455946 CYP4A22 cytochrome P450 family 4 subfamily A member 22 2 2
MIRT456935 LRP10 LDL receptor related protein 10 2 2
MIRT457223 AP3D1 adaptor related protein complex 3 delta 1 subunit 2 2
MIRT457431 NOL10 nucleolar protein 10 2 2
MIRT457470 SLC35F6 solute carrier family 35 member F6 2 2
MIRT457907 ZNF212 zinc finger protein 212 2 2
MIRT458046 TSEN54 tRNA splicing endonuclease subunit 54 2 2
MIRT458073 RNLS renalase, FAD dependent amine oxidase 2 2
MIRT458234 NXPH3 neurexophilin 3 2 2
MIRT458307 TNFAIP8L3 TNF alpha induced protein 8 like 3 2 2
MIRT458378 ITM2C integral membrane protein 2C 2 2
MIRT458967 ZNF436 zinc finger protein 436 2 2
MIRT459099 CYP4A11 cytochrome P450 family 4 subfamily A member 11 2 2
MIRT459446 TMEM37 transmembrane protein 37 2 2
MIRT459671 VPS37C VPS37C, ESCRT-I subunit 2 2
MIRT460727 ASXL3 additional sex combs like 3, transcriptional regulator 2 2
MIRT460744 SRP14 signal recognition particle 14 2 2
MIRT461531 C14orf1 ergosterol biosynthesis 28 homolog 2 2
MIRT461752 DDX11 DEAD/H-box helicase 11 2 2
MIRT461837 F2RL3 F2R like thrombin or trypsin receptor 3 2 2
MIRT462019 RIF1 replication timing regulatory factor 1 2 2
MIRT462631 PHF5A PHD finger protein 5A 2 2
MIRT462772 ZNF8 zinc finger protein 8 2 2
MIRT463032 ZNF689 zinc finger protein 689 2 2
MIRT463886 WNT7B Wnt family member 7B 2 2
MIRT463995 WDTC1 WD and tetratricopeptide repeats 1 2 2
MIRT464371 URM1 ubiquitin related modifier 1 2 2
MIRT465342 TPM3 tropomyosin 3 2 4
MIRT465515 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT465602 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT465697 TNPO2 transportin 2 2 10
MIRT466988 SSRP1 structure specific recognition protein 1 2 4
MIRT467630 SLC7A5 solute carrier family 7 member 5 2 2
MIRT468132 SH3PXD2A SH3 and PX domains 2A 2 2
MIRT468322 SF3B3 splicing factor 3b subunit 3 2 2
MIRT468502 SESN2 sestrin 2 2 2
MIRT468881 RREB1 ras responsive element binding protein 1 2 2
MIRT469322 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT469562 RARA retinoic acid receptor alpha 2 2
MIRT469898 PTRF caveolae associated protein 1 2 2
MIRT470045 PTGFRN prostaglandin F2 receptor inhibitor 2 2
MIRT470068 PTGES2 prostaglandin E synthase 2 2 2
MIRT470238 PRRC2A proline rich coiled-coil 2A 2 2
MIRT470390 PPP1R16B protein phosphatase 1 regulatory subunit 16B 2 2
MIRT470500 PPP1R11 protein phosphatase 1 regulatory inhibitor subunit 11 2 2
MIRT470689 POLR2D RNA polymerase II subunit D 2 2
MIRT470704 POGK pogo transposable element derived with KRAB domain 2 2
MIRT471083 PIK3C2B phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta 2 2
MIRT472482 NACC2 NACC family member 2 2 2
MIRT473583 MAT2A methionine adenosyltransferase 2A 2 2
MIRT474554 KLHDC3 kelch domain containing 3 2 2
MIRT474651 KLF13 Kruppel like factor 13 2 2
MIRT474843 KHSRP KH-type splicing regulatory protein 2 2
MIRT474934 KCTD15 potassium channel tetramerization domain containing 15 2 2
MIRT475573 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2 2
MIRT476045 GRSF1 G-rich RNA sequence binding factor 1 2 2
MIRT476080 GRB2 growth factor receptor bound protein 2 2 2
MIRT476440 GBA2 glucosylceramidase beta 2 2 2
MIRT476764 FOSL2 FOS like 2, AP-1 transcription factor subunit 2 2
MIRT478785 CRTC2 CREB regulated transcription coactivator 2 2 2
MIRT479287 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT479505 CDH6 cadherin 6 2 2
MIRT479732 CCND1 cyclin D1 2 6
MIRT480352 C5orf24 chromosome 5 open reading frame 24 2 2
MIRT480407 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT480859 BHLHB9 basic helix-loop-helix family member b9 2 2
MIRT481445 ARRB2 arrestin beta 2 2 2
MIRT481732 APH1A aph-1 homolog A, gamma-secretase subunit 2 2
MIRT481824 AP2M1 adaptor related protein complex 2 mu 1 subunit 2 2
MIRT482566 ABHD2 abhydrolase domain containing 2 2 2
MIRT482607 ABHD14B abhydrolase domain containing 14B 2 2
MIRT483144 SYCE1L synaptonemal complex central element protein 1 like 2 2
MIRT483214 APOA1 apolipoprotein A1 2 6
MIRT483878 TGIF1 TGFB induced factor homeobox 1 2 2
MIRT483917 SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 2 2
MIRT483939 LENG8 leukocyte receptor cluster member 8 2 4
MIRT484420 SNX19 sorting nexin 19 2 2
MIRT484489 SLC9A1 solute carrier family 9 member A1 2 2
MIRT484612 SIX3 SIX homeobox 3 2 6
MIRT484705 RNF11 ring finger protein 11 2 2
MIRT485107 SHISA6 shisa family member 6 2 2
MIRT485354 MYO1C myosin IC 2 4
MIRT485609 FOSL1 FOS like 1, AP-1 transcription factor subunit 2 4
MIRT487311 GLTSCR1 BRD4 interacting chromatin remodeling complex associated protein 2 2
MIRT487417 CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 2 2
MIRT487695 CDK14 cyclin dependent kinase 14 2 2
MIRT487791 GPR20 G protein-coupled receptor 20 2 4
MIRT488042 PABPC1L2B poly(A) binding protein cytoplasmic 1 like 2B 2 2
MIRT488058 PABPC1L2A poly(A) binding protein cytoplasmic 1 like 2A 2 2
MIRT488237 DNLZ DNL-type zinc finger 2 4
MIRT488764 FXYD1 FXYD domain containing ion transport regulator 1 2 2
MIRT489401 TUBB2A tubulin beta 2A class IIa 2 2
MIRT489777 GRINA glutamate ionotropic receptor NMDA type subunit associated protein 1 2 2
MIRT490099 FN3K fructosamine 3 kinase 2 2
MIRT490290 ISL2 ISL LIM homeobox 2 2 2
MIRT490378 LHFPL3 LHFPL tetraspan subfamily member 3 2 2
MIRT491329 GFER growth factor, augmenter of liver regeneration 2 2
MIRT491435 MSX2 msh homeobox 2 2 2
MIRT491769 ZNF385A zinc finger protein 385A 2 2
MIRT491922 WNK2 WNK lysine deficient protein kinase 2 2 2
MIRT491983 UNK unkempt family zinc finger 2 2
MIRT492228 SLC48A1 solute carrier family 48 member 1 2 2
MIRT492404 SDK1 sidekick cell adhesion molecule 1 2 2
MIRT492767 PDGFB platelet derived growth factor subunit B 2 2
MIRT492966 NCS1 neuronal calcium sensor 1 2 2
MIRT493295 LLGL2 LLGL2, scribble cell polarity complex component 2 2
MIRT493650 HDLBP high density lipoprotein binding protein 2 2
MIRT493913 FAM127B retrotransposon Gag like 8A 2 4
MIRT495601 NKX2-5 NK2 homeobox 5 2 2
MIRT496875 AHCYL2 adenosylhomocysteinase like 2 2 2
MIRT498514 MYH14 myosin heavy chain 14 2 2
MIRT499178 RBPJL recombination signal binding protein for immunoglobulin kappa J region like 2 2
MIRT502143 KIF5B kinesin family member 5B 2 8
MIRT502692 CSNK1G1 casein kinase 1 gamma 1 2 4
MIRT508460 HOXB6 homeobox B6 2 4
MIRT510430 ZNF207 zinc finger protein 207 2 6
MIRT511837 GPATCH8 G-patch domain containing 8 2 4
MIRT512368 CPM carboxypeptidase M 2 2
MIRT512506 BTBD19 BTB domain containing 19 2 2
MIRT513065 ANKRD45 ankyrin repeat domain 45 2 2
MIRT513267 SCUBE1 signal peptide, CUB domain and EGF like domain containing 1 2 4
MIRT513575 EVX1 even-skipped homeobox 1 2 2
MIRT515051 EBNA1BP2 EBNA1 binding protein 2 2 2
MIRT515790 COL4A3BP collagen type IV alpha 3 binding protein 2 2
MIRT521657 PRKD3 protein kinase D3 2 2
MIRT522679 LUZP1 leucine zipper protein 1 2 6
MIRT528845 RAB32 RAB32, member RAS oncogene family 2 2
MIRT533569 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT543738 DHCR7 7-dehydrocholesterol reductase 2 2
MIRT544295 TSPYL1 TSPY like 1 2 2
MIRT544857 MYH2 myosin heavy chain 2 2 4
MIRT557323 HIATL1 major facilitator superfamily domain containing 14B 2 4
MIRT560522 TMEM98 transmembrane protein 98 2 2
MIRT561565 SLC6A9 solute carrier family 6 member 9 2 2
MIRT562374 ERI2 ERI1 exoribonuclease family member 2 2 2
MIRT565780 SEMA6D semaphorin 6D 2 2
MIRT569548 UNC119B unc-119 lipid binding chaperone B 2 2
MIRT569944 PRRT2 proline rich transmembrane protein 2 2 2
MIRT570016 COL1A2 collagen type I alpha 2 chain 2 2
MIRT572163 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT572322 HSPB6 heat shock protein family B (small) member 6 2 2
MIRT573495 IQSEC3 IQ motif and Sec7 domain 3 2 2
MIRT574139 MARVELD1 MARVEL domain containing 1 2 2
MIRT609449 CCDC149 coiled-coil domain containing 149 2 2
MIRT610619 ARHGAP18 Rho GTPase activating protein 18 2 2
MIRT623355 LZIC leucine zipper and CTNNBIP1 domain containing 2 2
MIRT629854 ACOX1 acyl-CoA oxidase 1 2 2
MIRT630516 CDC73 cell division cycle 73 2 2
MIRT632535 PSMB2 proteasome subunit beta 2 2 2
MIRT633975 SLC35E2 solute carrier family 35 member E2 2 2
MIRT636408 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 2
MIRT641722 LTBR lymphotoxin beta receptor 2 2
MIRT642661 RGS6 regulator of G protein signaling 6 2 2
MIRT649649 MAST3 microtubule associated serine/threonine kinase 3 2 2
MIRT650367 MOCS3 molybdenum cofactor synthesis 3 2 2
MIRT651355 ZBTB40 zinc finger and BTB domain containing 40 2 2
MIRT664840 HUS1 HUS1 checkpoint clamp component 2 2
MIRT667322 MYH9 myosin heavy chain 9 2 2
MIRT670680 SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 2 2
MIRT674922 TRPM6 transient receptor potential cation channel subfamily M member 6 2 2
MIRT675919 CYP51A1 cytochrome P450 family 51 subfamily A member 1 2 2
MIRT676493 GJD3 gap junction protein delta 3 2 2
MIRT680162 ZDHHC20 zinc finger DHHC-type containing 20 2 2
MIRT688008 GSN gelsolin 2 2
MIRT688997 ATP6AP1 ATPase H+ transporting accessory protein 1 2 2
MIRT700337 RAB4A RAB4A, member RAS oncogene family 2 2
MIRT701344 NR4A3 nuclear receptor subfamily 4 group A member 3 2 2
MIRT703519 FKBP15 FK506 binding protein 15 2 2
MIRT703901 EPT1 selenoprotein I 2 2
MIRT705565 ARHGEF18 Rho/Rac guanine nucleotide exchange factor 18 2 2
MIRT709709 DNAJC11 DnaJ heat shock protein family (Hsp40) member C11 2 2
MIRT713108 TMBIM4 transmembrane BAX inhibitor motif containing 4 2 2
MIRT718426 ZNF85 zinc finger protein 85 2 2
MIRT719236 CYSLTR2 cysteinyl leukotriene receptor 2 2 2
MIRT719326 STAC SH3 and cysteine rich domain 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4747 Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4747-5p Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-4747-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4747-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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