miRTarBase - #MIRT464134


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pre-miRNA Information
pre-miRNA hsa-mir-499a   
Genomic Coordinates chr20: 34990376 - 34990497
Description Homo sapiens miR-499a stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-499a-3p
Sequence 70| AACAUCACAGCAAGUCUGUGCU |91
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30512073 1 COSMIC
COSN8868602 4 COSMIC
COSN20079766 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs768246420 3 dbSNP
rs3746444 4 dbSNP
rs761417578 6 dbSNP
rs150018420 8 dbSNP
rs1406470841 9 dbSNP
rs772652105 11 dbSNP
rs1189840352 16 dbSNP
rs759966338 17 dbSNP
rs1475405341 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol VPS35   
Synonyms MEM3, PARK17
Description VPS35, retromer complex component
Transcript NM_018206   
Expression
Putative miRNA Targets on VPS35
3'UTR of VPS35
(miRNA target sites are highlighted)		 
>VPS35|NM_018206|3'UTR
   1 AAAGGAAATAGCTCACCATACTCCTTTCCATGTACATCCAGTGAGGGTTTTATTACGCTAGGTTTCCCTTCCATAGATTG
  81 TGCCTTTCAGAAATGCTGAGGTAGGTTTCCCATTTCTTACCTGTGATGTGTTTTACCCAGCACCTCCGGACACTCACCTT
 161 CAGGACCTTAATAAAATTATTCACTTGGTAAGTGTTCAAGTCTTTCTGATCACCCCAAGTAGCATGACTGATCTGCAATT
 241 TAAAATTCCTGTGATCTGTAAAAAAAAAAAAAAAAAAAAAAACAAAACCCACAAGCACTTATCTTGGCTACTAATGAAGC
 321 TCTCCTTTTTTTTGTTTGTTTGTTTGCTTCATTGTTGATTGTGTATTTTCTTCATTCCTGGGGAGTACTAACCCAAAAGC
 401 GTCTGTCTCTTGTTTTCTAGTCCAGTTTGAGATTAATTTAGAAGAAAGGAATACTGTATGTGAAATTCATCTTGGGCTTT
 481 CCCCTAAATTGCAAGATAAGGCCATGTGTAAGATTTTCCCTAAAACTAGAATATATTAATGCATGTTTGAGAATTTTAAA
 561 GCACCATGGTCAAAACCAGAAGCTATATTTTGCATATTTGGACTCAGCCATCCATTAAGAACCCATGTTGTCCTCTGGAC
 641 ATATTTATCAATATAATTGGGTTTTAAATAGTATAAAAGAAAACTTGTGATCTATATAATTTATGTATCACCTTCATTGT
 721 AAATTTAGCAGGAAATGCATCACAATTATGATTTTTTTTTTTGCACCAGTGAAACAATAAAGATGCTATTAACAATTTTG
 801 GAGCTTTTTTTCCCCTTTCATACTATCTTTAATTGATAAAAAGTACTAGTAGTATGGCTATAGAGTTTAATAGTCATTCT
 881 CATATATTCACAGAGCTCACTTAACTCTAGTTTTAAGCACTTGTTGAACAAGGCAGCATCTACTCTTTTAGTCATTTATA
 961 CCCCTTTTCTTTCCTCAACTTTACCCTGCTTTTCCCAAGGCATGATGAATTCACATAAACCCCCCAAAGGCTCACCACCG
1041 ATACTAGTTACCTACTATATAATAAACCATCCCAAAACTTACTGTCTTAAAACAGCAAACATTTATCTCACAGGTCTCTG
1121 GATCAGGAATTTGGGAGCAGCTTAGCTGGTGGTTCTGGCAAAGAGTGTGGTGTAAGGTTGCAAACAAGATACTGGTTGGG
1201 GCTGCAGTCATCTGATGCTTTGACTGGGGCTGACTTTTCTGCTCACTGACCTGGCTGTTAGGCAGAGGCCCCAGTTCCTC
1281 TTCTTGAGGGCAGAGGCCCCAGTTCCTCTCCTTGAGGGCAGAGGCCTAAGTTCCTTTCCTTGAGGGCAGAGGCCCCAGTT
1361 CCTCTCCTTGACGGCCCTTCCATAGAGTGTCCTCACAGCATGGTGGCTGGCTTTCCCCTGAGTATGAAAGCAAGAAGGAA
1441 ACCACAGTGCCTTTCAGTGGCCTCCCTGTGGAAGTGACATGCTCATTTTTGCCTTATTCTGTAAGTGGGGAGTCACTAAG
1521 TCTAGCCTATATTCAAGGGTAAGGAGAATTAAGCTCCACCTCTTAAAGGGAAAATTTATAGACATTTTCAAATGACTACA
1601 TCACTTAACCCCTCACCATCTGCCCTCCCATTGCTAGCACTTGATGACTAGCCCTTGCTGGGCTTTACATGAACAGATGT
1681 TTCCCAAAGTTATAAAATTAGTACCACTAAAATGTATCAAATGTTAAGCCATTCTGTGGTATGTCATAGTCCAGCAAACC
1761 CTTTCTGTTCTTTGTAGGTGTTAGTTTACCCCGTATAAACCTGATTATGGCTTGACATGTCCATATTATTTACATGTTTT
1841 GTGAAATACAACTGGAATAGTAGAAAAGACATGAGTCAAGAACACTTGAGTTGGAGAGCTTGGTTTGCAAGTAAGGTAAT
1921 GTCAGTACAGTGTGTAAATTATCTCTTATTTTCTGGGTTGAGGTAAACCCAATTTTAAAAATAATAAACCAACAAAAGTA
2001 AATAAAAGTGAAACAAAAGCACTGCTAGTATCCTTAACTTACAGATTTTTTTTGTTGAACAAAAACTGGGTACCAGATAT
2081 AGTTAGGCACTGAATCTAAAGGTGAAGAAGATCATAGCCTCTAGCTTCAAGAACGTTAGTCTGCTGTGAAGACAGACCTG
2161 TAGTTACAGAAGATGGTAAGGGTTTGTGCAGGAGAGCAGTGAAGAAGAGCTTTGAGGGATTGGGGATGGGGAAGTTCTGC
2241 AGAGGGTTGTATGAATTCTCATGGAACATCAAGTCCAATAGTTTATTTAGCCTTCTGAGGCCAGTGCTTTGGCCTGCAGT
2321 CCCAGGCTCCTCAGACCCATGGGCTGAAGCAAGTTATACTCTTGGCTGCCTGTAGTGAAATAGATATTTAGAAATTGACT
2401 TAGCATTTAAAACCCTTTATAGCAATTTGACAGAGTAATTTTATGTCTATTGGATGTAATAAATATTTGGCTTTGTGCTT
2481 TGTGTGTCTGCTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucgugucuGAA-CGACACUACAa 5'
                  |||  ||||||||| 
Target 5' tcccatttCTTACCTGTGATGTg 3'
 108 - 130 154.00 -13.50
2 
miRNA  3' ucGUGUCUGAACGACACUACAa 5'
            || |||   | ||||:||| 
Target 5' ggCAAAGA---G-TGTGGTGTa 3'
 1157 - 1174 136.00 -11.20
3 
miRNA  3' ucguGUCUGAACGACACUACAa 5'
              :| | || ||||||| | 
Target 5' aattTAAAATTCCTGTGATCTg 3'
 237 - 258 130.00 -6.82
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
886614 34 ClinVar
886613 161 ClinVar
319288 259 ClinVar
319287 261 ClinVar
319285 276 ClinVar
319286 276 ClinVar
319284 277 ClinVar
319283 278 ClinVar
319282 279 ClinVar
319281 280 ClinVar
319279 281 ClinVar
319280 281 ClinVar
886612 283 ClinVar
319278 284 ClinVar
319277 285 ClinVar
319273 288 ClinVar
319274 288 ClinVar
319275 288 ClinVar
319276 288 ClinVar
886611 289 ClinVar
886610 345 ClinVar
319272 346 ClinVar
319271 354 ClinVar
319270 380 ClinVar
319269 401 ClinVar
885588 422 ClinVar
885587 575 ClinVar
319268 617 ClinVar
319266 763 ClinVar
319267 763 ClinVar
COSN31581716 1 COSMIC
COSN30181982 23 COSMIC
COSN30151009 28 COSMIC
COSN30177635 30 COSMIC
COSN13672664 48 COSMIC
COSN27004707 56 COSMIC
COSN30471560 71 COSMIC
COSN30521513 90 COSMIC
COSN31560335 141 COSMIC
COSN31558657 174 COSMIC
COSN31543534 189 COSMIC
COSN30025381 217 COSMIC
COSN20112846 281 COSMIC
COSN28960507 281 COSMIC
COSN30130097 289 COSMIC
COSN22274363 811 COSMIC
COSN9646816 927 COSMIC
COSN8391477 1208 COSMIC
COSN18723329 1814 COSMIC
COSN25219100 2667 COSMIC
COSN21948519 2808 COSMIC
COSN9220952 2921 COSMIC
COSN16603250 2939 COSMIC
COSN9220951 3020 COSMIC
COSN16962880 3277 COSMIC
COSN5834858 3664 COSMIC
COSN8391476 3837 COSMIC
COSN21695642 3975 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs200195623 2 dbSNP
rs570492580 4 dbSNP
rs1324849965 5 dbSNP
rs183923278 7 dbSNP
rs188654478 8 dbSNP
rs189948577 11 dbSNP
rs1307257172 12 dbSNP
rs780867284 18 dbSNP
rs754730255 21 dbSNP
rs751335821 27 dbSNP
rs1252276941 28 dbSNP
rs779980787 34 dbSNP
rs758270070 36 dbSNP
rs1156800231 38 dbSNP
rs1406266454 40 dbSNP
rs750436964 41 dbSNP
rs765392455 43 dbSNP
rs1182777844 45 dbSNP
rs970135927 46 dbSNP
rs527800239 54 dbSNP
rs185420432 56 dbSNP
rs548502981 57 dbSNP
rs1331993238 59 dbSNP
rs1416521259 60 dbSNP
rs1022087928 63 dbSNP
rs1031732732 72 dbSNP
rs112747048 73 dbSNP
rs1011657508 74 dbSNP
rs530305374 77 dbSNP
rs968423274 80 dbSNP
rs977203062 80 dbSNP
rs1251150107 84 dbSNP
rs1481153945 103 dbSNP
rs1427823670 120 dbSNP
rs1267377794 127 dbSNP
rs1479171445 135 dbSNP
rs1421756503 136 dbSNP
rs1168658911 143 dbSNP
rs759782658 147 dbSNP
rs774726845 148 dbSNP
rs563219537 167 dbSNP
rs1353757078 175 dbSNP
rs1367051213 176 dbSNP
rs1462291302 178 dbSNP
rs11550461 179 dbSNP
rs1190571241 180 dbSNP
rs759445626 182 dbSNP
rs999417037 185 dbSNP
rs1486275580 192 dbSNP
rs1343504237 199 dbSNP
rs1404437661 208 dbSNP
rs544896659 217 dbSNP
rs1283961265 220 dbSNP
rs1347436598 233 dbSNP
rs1213086568 239 dbSNP
rs1295115112 242 dbSNP
rs1205397932 258 dbSNP
rs1311613797 259 dbSNP
rs886052012 259 dbSNP
rs59370839 260 dbSNP
rs901069434 260 dbSNP
rs1019415284 261 dbSNP
rs886052011 261 dbSNP
rs71852726 262 dbSNP
rs1274544269 267 dbSNP
rs1214768498 269 dbSNP
rs1184468285 270 dbSNP
rs1478711805 270 dbSNP
rs1418343586 271 dbSNP
rs1170195664 272 dbSNP
rs1007771782 273 dbSNP
rs1303670652 274 dbSNP
rs1351750818 274 dbSNP
rs1282199903 275 dbSNP
rs886052009 276 dbSNP
rs886052010 276 dbSNP
rs886052008 277 dbSNP
rs886052007 278 dbSNP
rs575317929 279 dbSNP
rs886052006 280 dbSNP
rs1491413604 281 dbSNP
rs752834205 281 dbSNP
rs808078 281 dbSNP
rs373111906 282 dbSNP
rs1317779618 283 dbSNP
rs1334942840 283 dbSNP
rs1453829968 283 dbSNP
rs199765664 283 dbSNP
rs369756092 283 dbSNP
rs889270416 283 dbSNP
rs878915318 284 dbSNP
rs886052005 284 dbSNP
rs879039152 285 dbSNP
rs879053227 285 dbSNP
rs1053393 286 dbSNP
rs1157892963 286 dbSNP
rs1407942282 287 dbSNP
rs1458876246 288 dbSNP
rs369068093 288 dbSNP
rs145606241 289 dbSNP
rs1336514230 295 dbSNP
rs1334320379 301 dbSNP
rs1280635982 302 dbSNP
rs1329663099 302 dbSNP
rs1350650776 314 dbSNP
rs998146101 318 dbSNP
rs1260884535 322 dbSNP
rs1322341837 326 dbSNP
rs1404963285 330 dbSNP
rs1204092078 334 dbSNP
rs1435840337 334 dbSNP
rs897842857 334 dbSNP
rs1388915651 338 dbSNP
rs1167544785 342 dbSNP
rs1006640513 345 dbSNP
rs545755034 346 dbSNP
rs1428898322 347 dbSNP
rs564951006 347 dbSNP
rs887896442 347 dbSNP
rs1394857678 348 dbSNP
rs572048744 354 dbSNP
rs1330157661 355 dbSNP
rs1372889262 357 dbSNP
rs1411152647 360 dbSNP
rs1045123990 362 dbSNP
rs948578513 372 dbSNP
rs886052004 380 dbSNP
rs1450685198 381 dbSNP
rs776500632 383 dbSNP
rs1337280819 387 dbSNP
rs992778344 399 dbSNP
rs543740178 400 dbSNP
rs553790361 401 dbSNP
rs1204783373 408 dbSNP
rs1220120087 409 dbSNP
rs1268334161 419 dbSNP
rs181198454 422 dbSNP
rs977527968 442 dbSNP
rs1226460588 451 dbSNP
rs968372667 453 dbSNP
rs188743379 454 dbSNP
rs1168806960 463 dbSNP
rs1021409720 466 dbSNP
rs1423336541 483 dbSNP
rs1303049087 495 dbSNP
rs1364469274 499 dbSNP
rs774565598 501 dbSNP
rs1386840173 503 dbSNP
rs1325119002 507 dbSNP
rs1324259878 508 dbSNP
rs1170821357 512 dbSNP
rs1375507245 512 dbSNP
rs985863143 513 dbSNP
rs938925484 516 dbSNP
rs1280196522 520 dbSNP
rs1435931737 528 dbSNP
rs1243760725 529 dbSNP
rs1290942511 531 dbSNP
rs953537707 536 dbSNP
rs1328116447 539 dbSNP
rs1211659789 543 dbSNP
rs1462194699 545 dbSNP
rs1446601338 556 dbSNP
rs928836241 566 dbSNP
rs768759859 575 dbSNP
rs542974709 583 dbSNP
rs780922363 584 dbSNP
rs1228042531 585 dbSNP
rs754785560 587 dbSNP
rs1157467112 593 dbSNP
rs1163579153 606 dbSNP
rs948904221 608 dbSNP
rs1409446083 610 dbSNP
rs762727734 612 dbSNP
rs746602580 617 dbSNP
rs1382363284 622 dbSNP
rs779756007 625 dbSNP
rs1381352102 633 dbSNP
rs749705519 644 dbSNP
rs887760536 659 dbSNP
rs1450107626 664 dbSNP
rs1195065526 665 dbSNP
rs1045140300 669 dbSNP
rs1468672014 675 dbSNP
rs1012263955 683 dbSNP
rs1213453604 691 dbSNP
rs1247126529 692 dbSNP
rs1259085362 695 dbSNP
rs894312500 699 dbSNP
rs11550460 700 dbSNP
rs1032102320 705 dbSNP
rs1209657501 708 dbSNP
rs1250125500 719 dbSNP
rs976022796 726 dbSNP
rs1318650833 732 dbSNP
rs1183307752 736 dbSNP
rs965268731 737 dbSNP
rs758047233 739 dbSNP
rs1006755372 748 dbSNP
rs1426030741 761 dbSNP
rs34926621 762 dbSNP
rs889649099 762 dbSNP
rs1310527035 763 dbSNP
rs1390318087 763 dbSNP
rs938523361 763 dbSNP
rs183646374 764 dbSNP
rs1335796273 765 dbSNP
rs1379589586 768 dbSNP
rs1397761967 769 dbSNP
rs1304765338 782 dbSNP
rs924564635 788 dbSNP
rs1441890353 803 dbSNP
rs1270264092 804 dbSNP
rs1321610176 806 dbSNP
rs1203466780 811 dbSNP
rs1364813267 812 dbSNP
rs1484435551 812 dbSNP
rs575736800 814 dbSNP
rs191441368 826 dbSNP
rs1250351164 837 dbSNP
rs1471986723 838 dbSNP
rs1182214214 843 dbSNP
rs1698957 844 dbSNP
rs1479277466 856 dbSNP
rs1346175885 857 dbSNP
rs1175240081 859 dbSNP
rs780263080 860 dbSNP
rs1413296370 865 dbSNP
rs1467381984 865 dbSNP
rs1296386645 868 dbSNP
rs1395610045 879 dbSNP
rs560695968 881 dbSNP
rs1290247606 903 dbSNP
rs896871563 915 dbSNP
rs1036705471 944 dbSNP
rs1302240117 947 dbSNP
rs1247100474 949 dbSNP
rs1184407629 950 dbSNP
rs141839860 953 dbSNP
rs1202798225 958 dbSNP
rs1486689967 963 dbSNP
rs1207887065 969 dbSNP
rs1253413591 969 dbSNP
rs976689787 972 dbSNP
rs1242521859 973 dbSNP
rs906864075 974 dbSNP
rs1209299072 978 dbSNP
rs542697419 985 dbSNP
rs552312462 988 dbSNP
rs1425350298 1002 dbSNP
rs1282548528 1010 dbSNP
rs1434697781 1012 dbSNP
rs868028366 1013 dbSNP
rs948936848 1016 dbSNP
rs962233424 1019 dbSNP
rs1389513871 1021 dbSNP
rs914748498 1035 dbSNP
rs1341555727 1037 dbSNP
rs794557 1039 dbSNP
rs934749814 1043 dbSNP
rs1309749985 1051 dbSNP
rs1363864201 1052 dbSNP
rs1216574534 1056 dbSNP
rs1363042317 1057 dbSNP
rs1294357746 1071 dbSNP
rs1006413868 1073 dbSNP
rs1446427594 1078 dbSNP
rs79050797 1081 dbSNP
rs138252903 1082 dbSNP
rs1290206904 1098 dbSNP
rs966053109 1100 dbSNP
rs1017548118 1101 dbSNP
rs145628294 1105 dbSNP
rs553910416 1108 dbSNP
rs112150674 1109 dbSNP
rs1427464847 1112 dbSNP
rs866627684 1118 dbSNP
rs1449842792 1120 dbSNP
rs1170419477 1143 dbSNP
rs1429974482 1148 dbSNP
rs961419713 1167 dbSNP
rs1383242136 1172 dbSNP
rs1003144925 1177 dbSNP
rs1181125818 1185 dbSNP
rs1165525127 1187 dbSNP
rs1015389933 1188 dbSNP
rs530343884 1194 dbSNP
rs903004957 1195 dbSNP
rs1002615221 1208 dbSNP
rs115810403 1217 dbSNP
rs1366453918 1222 dbSNP
rs1044065988 1223 dbSNP
rs1437635342 1226 dbSNP
rs1013604145 1231 dbSNP
rs1259449848 1235 dbSNP
rs76259065 1244 dbSNP
rs148961435 1246 dbSNP
rs934885050 1247 dbSNP
rs1290015578 1253 dbSNP
rs1050052677 1254 dbSNP
rs1213284889 1256 dbSNP
rs931658990 1257 dbSNP
rs1465194639 1259 dbSNP
rs1190217826 1262 dbSNP
rs1308348485 1263 dbSNP
rs1241234192 1269 dbSNP
rs1472451632 1279 dbSNP
rs924767526 1280 dbSNP
rs1312434737 1282 dbSNP
rs1416130032 1283 dbSNP
rs1399023577 1284 dbSNP
rs1040466462 1288 dbSNP
rs1389576855 1298 dbSNP
rs1459175725 1299 dbSNP
rs944776962 1300 dbSNP
rs1335090578 1307 dbSNP
rs1340214690 1310 dbSNP
rs1449463336 1326 dbSNP
rs910573206 1327 dbSNP
rs1294380439 1328 dbSNP
rs1380715894 1328 dbSNP
rs1409770400 1331 dbSNP
rs1221517040 1336 dbSNP
rs986063443 1338 dbSNP
rs954104826 1341 dbSNP
rs1329374638 1354 dbSNP
rs1210177662 1355 dbSNP
rs188470349 1358 dbSNP
rs1441623303 1370 dbSNP
rs985012169 1372 dbSNP
rs1239059003 1373 dbSNP
rs545490118 1380 dbSNP
rs974392667 1382 dbSNP
rs961268585 1384 dbSNP
rs1023833955 1385 dbSNP
rs1174517943 1387 dbSNP
rs1015422591 1393 dbSNP
rs1415399139 1403 dbSNP
rs746409661 1404 dbSNP
rs1012244423 1424 dbSNP
rs1002647864 1434 dbSNP
rs1353218396 1438 dbSNP
rs1407492433 1444 dbSNP
rs1287206836 1460 dbSNP
rs971112723 1464 dbSNP
rs1229914476 1470 dbSNP
rs1272716719 1475 dbSNP
rs539333964 1478 dbSNP
rs1022646050 1479 dbSNP
rs1012544695 1481 dbSNP
rs1435964089 1491 dbSNP
rs749537563 1491 dbSNP
rs892792235 1496 dbSNP
rs1252688153 1499 dbSNP
rs865874834 1504 dbSNP
rs960724122 1506 dbSNP
rs1197617035 1509 dbSNP
rs1377214894 1511 dbSNP
rs1054749390 1514 dbSNP
rs1174637833 1516 dbSNP
rs1188521359 1517 dbSNP
rs571998815 1519 dbSNP
rs1472245257 1534 dbSNP
rs999589398 1536 dbSNP
rs560037141 1541 dbSNP
rs794558 1548 dbSNP
rs1309163393 1549 dbSNP
rs1370712397 1550 dbSNP
rs1411062624 1554 dbSNP
rs1020089209 1557 dbSNP
rs774644453 1558 dbSNP
rs1011505680 1559 dbSNP
rs903387301 1560 dbSNP
rs112333048 1570 dbSNP
rs1050331744 1576 dbSNP
rs1212069131 1577 dbSNP
rs1227646089 1578 dbSNP
rs1337343446 1579 dbSNP
rs1344413697 1580 dbSNP
rs1220286937 1584 dbSNP
rs555956898 1585 dbSNP
rs375977006 1587 dbSNP
rs1274231836 1595 dbSNP
rs1266980099 1597 dbSNP
rs763130659 1599 dbSNP
rs1228296528 1600 dbSNP
rs944807993 1612 dbSNP
rs568752537 1613 dbSNP
rs371605094 1616 dbSNP
rs1449241440 1617 dbSNP
rs1169791477 1624 dbSNP
rs910600737 1625 dbSNP
rs1050857429 1627 dbSNP
rs773307805 1628 dbSNP
rs920582852 1629 dbSNP
rs974045223 1630 dbSNP
rs1389345271 1631 dbSNP
rs1387040611 1641 dbSNP
rs537393708 1644 dbSNP
rs1324750739 1654 dbSNP
rs908392784 1666 dbSNP
rs1362847598 1667 dbSNP
rs981243084 1670 dbSNP
rs1459578237 1672 dbSNP
rs1434003195 1673 dbSNP
rs748025305 1680 dbSNP
rs11647138 1685 dbSNP
rs984958128 1693 dbSNP
rs991640359 1697 dbSNP
rs1456623855 1704 dbSNP
rs1362055760 1706 dbSNP
rs930810204 1722 dbSNP
rs916856334 1728 dbSNP
rs957091382 1731 dbSNP
rs558779814 1746 dbSNP
rs1250472932 1751 dbSNP
rs1033074836 1753 dbSNP
rs1443367417 1757 dbSNP
rs1187429759 1761 dbSNP
rs768650421 1784 dbSNP
rs1457963813 1785 dbSNP
rs866269780 1792 dbSNP
rs533970325 1793 dbSNP
rs1321026328 1794 dbSNP
rs1367069601 1806 dbSNP
rs939828968 1814 dbSNP
rs1008978648 1821 dbSNP
rs889279153 1822 dbSNP
rs966782513 1823 dbSNP
rs1186061489 1834 dbSNP
rs1247015278 1835 dbSNP
rs1286716340 1838 dbSNP
rs566858054 1838 dbSNP
rs1328699183 1841 dbSNP
rs930707552 1846 dbSNP
rs779764620 1849 dbSNP
rs1482472240 1851 dbSNP
rs1036747921 1865 dbSNP
rs1254008642 1870 dbSNP
rs794559 1883 dbSNP
rs908420454 1885 dbSNP
rs1189389267 1888 dbSNP
rs1409088078 1889 dbSNP
rs892955918 1899 dbSNP
rs981354618 1900 dbSNP
rs374027606 1923 dbSNP
rs1028942634 1924 dbSNP
rs949898939 1928 dbSNP
rs1348990767 1932 dbSNP
rs996078302 1943 dbSNP
rs1302209424 1947 dbSNP
rs901509278 1947 dbSNP
rs1397888068 1948 dbSNP
rs570059770 1969 dbSNP
rs1349927801 1970 dbSNP
rs1040006441 1972 dbSNP
rs1229308153 1972 dbSNP
rs1310814393 1984 dbSNP
rs1232919230 1985 dbSNP
rs1316947816 1995 dbSNP
rs1302114576 2000 dbSNP
rs1484548917 2003 dbSNP
rs1203603655 2010 dbSNP
rs940342351 2013 dbSNP
rs1181696863 2035 dbSNP
rs548431200 2037 dbSNP
rs1182454376 2038 dbSNP
rs114654822 2042 dbSNP
rs1326324533 2043 dbSNP
rs1381373328 2047 dbSNP
rs1431247494 2048 dbSNP
rs1175035569 2051 dbSNP
rs200961009 2054 dbSNP
rs1160177488 2069 dbSNP
rs1306095967 2070 dbSNP
rs536731227 2077 dbSNP
rs1454274177 2080 dbSNP
rs752584142 2089 dbSNP
rs1310101837 2094 dbSNP
rs1365696606 2096 dbSNP
rs150247715 2101 dbSNP
rs112939943 2102 dbSNP
rs939578191 2112 dbSNP
rs1274463804 2117 dbSNP
rs547249927 2117 dbSNP
rs879180711 2119 dbSNP
rs1205185639 2120 dbSNP
rs527341985 2121 dbSNP
rs1234282378 2123 dbSNP
rs1487326873 2125 dbSNP
rs560084002 2128 dbSNP
rs1019192553 2135 dbSNP
rs1395850077 2143 dbSNP
rs1190252533 2157 dbSNP
rs1267873043 2162 dbSNP
rs753188016 2167 dbSNP
rs1166649619 2170 dbSNP
rs966695803 2176 dbSNP
rs1430511549 2178 dbSNP
rs1172573251 2185 dbSNP
rs1022411946 2189 dbSNP
rs1457645526 2191 dbSNP
rs1009094491 2196 dbSNP
rs889310332 2199 dbSNP
rs1029555884 2220 dbSNP
rs1275414609 2231 dbSNP
rs1433270623 2237 dbSNP
rs1297536902 2244 dbSNP
rs1366501641 2248 dbSNP
rs541382201 2249 dbSNP
rs1274567725 2251 dbSNP
rs1445594019 2259 dbSNP
rs1319394604 2261 dbSNP
rs184888157 2262 dbSNP
rs899216001 2264 dbSNP
rs1206209739 2266 dbSNP
rs1469663537 2270 dbSNP
rs1483235594 2278 dbSNP
rs996505547 2280 dbSNP
rs1450050821 2288 dbSNP
rs1278973483 2291 dbSNP
rs1411800658 2292 dbSNP
rs1231522896 2297 dbSNP
rs966024036 2301 dbSNP
rs1303612819 2314 dbSNP
rs1036372644 2317 dbSNP
rs1456001403 2318 dbSNP
rs781763237 2319 dbSNP
rs1389819193 2324 dbSNP
rs886095323 2324 dbSNP
rs940711226 2325 dbSNP
rs1282942355 2329 dbSNP
rs780126752 2331 dbSNP
rs1227192161 2333 dbSNP
rs1313018270 2337 dbSNP
rs1336442124 2340 dbSNP
rs1324427641 2345 dbSNP
rs1320091063 2346 dbSNP
rs906524935 2349 dbSNP
rs1048812311 2356 dbSNP
rs1472520989 2357 dbSNP
rs746904233 2357 dbSNP
rs1420070427 2368 dbSNP
rs1471759227 2381 dbSNP
rs1374847849 2387 dbSNP
rs1413249256 2395 dbSNP
rs994524012 2404 dbSNP
rs879811262 2407 dbSNP
rs895322749 2414 dbSNP
rs1359045191 2420 dbSNP
rs1045708234 2449 dbSNP
rs1436598848 2450 dbSNP
rs755598539 2454 dbSNP
rs1226264739 2456 dbSNP
rs193290216 2466 dbSNP
rs915767223 2470 dbSNP
rs991704533 2479 dbSNP
rs1276454815 2481 dbSNP
rs188296214 2487 dbSNP
rs867577072 2492 dbSNP
rs547937267 2493 dbSNP
rs1210694470 2501 dbSNP
rs925652164 2505 dbSNP
rs1255936750 2512 dbSNP
rs1482115063 2523 dbSNP
rs1181739421 2526 dbSNP
rs1252743263 2530 dbSNP
rs1471375101 2534 dbSNP
rs1171147554 2539 dbSNP
rs1424863814 2544 dbSNP
rs977136554 2545 dbSNP
rs967049439 2565 dbSNP
rs911544022 2570 dbSNP
rs1043013859 2572 dbSNP
rs1407387025 2577 dbSNP
rs141018966 2578 dbSNP
rs1307049809 2579 dbSNP
rs1335938082 2581 dbSNP
rs1443880824 2582 dbSNP
rs1436458841 2590 dbSNP
rs1486338691 2594 dbSNP
rs987705209 2594 dbSNP
rs114021432 2595 dbSNP
rs1282302637 2598 dbSNP
rs915215686 2612 dbSNP
rs1029174684 2613 dbSNP
rs558629585 2626 dbSNP
rs1252853445 2635 dbSNP
rs989581725 2642 dbSNP
rs1271712308 2646 dbSNP
rs540514296 2655 dbSNP
rs1246549865 2676 dbSNP
rs954077619 2678 dbSNP
rs1354596133 2689 dbSNP
rs921341344 2692 dbSNP
rs1427296434 2696 dbSNP
rs573016205 2704 dbSNP
rs963575549 2706 dbSNP
rs1015458114 2707 dbSNP
rs1411359743 2710 dbSNP
rs555007783 2714 dbSNP
rs906557474 2715 dbSNP
rs1441292626 2716 dbSNP
rs766691646 2721 dbSNP
rs1014195282 2733 dbSNP
rs1005181399 2745 dbSNP
rs1328333719 2749 dbSNP
rs1208291125 2758 dbSNP
rs1408411755 2758 dbSNP
rs1398988817 2762 dbSNP
rs1452571790 2781 dbSNP
rs1215898724 2803 dbSNP
rs950407240 2805 dbSNP
rs1027239941 2812 dbSNP
rs1461195252 2814 dbSNP
rs1373211064 2827 dbSNP
rs1476072958 2828 dbSNP
rs894352151 2830 dbSNP
rs536621510 2834 dbSNP
rs994552017 2836 dbSNP
rs1389507903 2848 dbSNP
rs1190647376 2859 dbSNP
rs1327718523 2860 dbSNP
rs1386159646 2861 dbSNP
rs894930668 2866 dbSNP
rs1296203657 2874 dbSNP
rs1242634817 2892 dbSNP
rs1328289525 2892 dbSNP
rs1055278948 2893 dbSNP
rs1335776492 2894 dbSNP
rs1215760783 2899 dbSNP
rs1237527336 2906 dbSNP
rs1266688069 2907 dbSNP
rs1055636870 2912 dbSNP
rs532677385 2917 dbSNP
rs1264408499 2927 dbSNP
rs906681273 2936 dbSNP
rs925799654 2938 dbSNP
rs1196041328 2940 dbSNP
rs1333834863 2947 dbSNP
rs1041474557 2955 dbSNP
rs557475498 2956 dbSNP
rs915246843 2969 dbSNP
rs183765045 2996 dbSNP
rs1456454199 3005 dbSNP
rs539264766 3011 dbSNP
rs1053821437 3014 dbSNP
rs932637215 3022 dbSNP
rs1394183870 3043 dbSNP
rs1333645134 3048 dbSNP
rs921382439 3052 dbSNP
rs977228813 3060 dbSNP
rs1286609013 3073 dbSNP
rs1328925446 3075 dbSNP
rs151089279 3080 dbSNP
rs911575196 3081 dbSNP
rs987067958 3083 dbSNP
rs1263051990 3085 dbSNP
rs1343545452 3086 dbSNP
rs965921671 3091 dbSNP
rs953662715 3095 dbSNP
rs983336244 3100 dbSNP
rs935917242 3102 dbSNP
rs1249101349 3103 dbSNP
rs1392696603 3108 dbSNP
rs1027518888 3112 dbSNP
rs973080233 3122 dbSNP
rs922138088 3123 dbSNP
rs1464531210 3124 dbSNP
rs973672590 3125 dbSNP
rs959276988 3128 dbSNP
rs750628966 3135 dbSNP
rs1003675641 3147 dbSNP
rs547018651 3150 dbSNP
rs1021500895 3151 dbSNP
rs1015082598 3154 dbSNP
rs1309668727 3159 dbSNP
rs894102405 3164 dbSNP
rs1233246517 3165 dbSNP
rs1004989673 3171 dbSNP
rs528789560 3183 dbSNP
rs1281590404 3186 dbSNP
rs1348002379 3188 dbSNP
rs1212353848 3192 dbSNP
rs765239709 3196 dbSNP
rs145706280 3200 dbSNP
rs1468115670 3206 dbSNP
rs1234147079 3216 dbSNP
rs547802662 3222 dbSNP
rs566134443 3223 dbSNP
rs1436696421 3228 dbSNP
rs571562249 3232 dbSNP
rs895143497 3253 dbSNP
rs1462740946 3256 dbSNP
rs1041156146 3260 dbSNP
rs1365936462 3264 dbSNP
rs550059578 3272 dbSNP
rs1373877728 3273 dbSNP
rs776752985 3280 dbSNP
rs1000102437 3284 dbSNP
rs1306406796 3288 dbSNP
rs1204778484 3292 dbSNP
rs1283397317 3310 dbSNP
rs904377122 3311 dbSNP
rs1041506743 3312 dbSNP
rs1252639713 3318 dbSNP
rs929137909 3326 dbSNP
rs1487393935 3327 dbSNP
rs1212800114 3336 dbSNP
rs1253366534 3343 dbSNP
rs1455573632 3347 dbSNP
rs945811873 3353 dbSNP
rs911607756 3355 dbSNP
rs973278875 3359 dbSNP
rs1352878536 3362 dbSNP
rs368519455 3365 dbSNP
rs1172825989 3375 dbSNP
rs1280250876 3377 dbSNP
rs1348314616 3378 dbSNP
rs1461088125 3382 dbSNP
rs1440416262 3387 dbSNP
rs531247169 3390 dbSNP
rs562273929 3393 dbSNP
rs1369125957 3411 dbSNP
rs1397124708 3416 dbSNP
rs1433608146 3417 dbSNP
rs1328179248 3418 dbSNP
rs543903630 3422 dbSNP
rs1051380103 3423 dbSNP
rs1442025871 3426 dbSNP
rs959082566 3431 dbSNP
rs1214592208 3435 dbSNP
rs1297318456 3438 dbSNP
rs192572698 3440 dbSNP
rs1344998466 3452 dbSNP
rs1316804194 3462 dbSNP
rs1273647820 3467 dbSNP
rs187040910 3471 dbSNP
rs1206749097 3472 dbSNP
rs1241392362 3474 dbSNP
rs1486248892 3479 dbSNP
rs867665496 3480 dbSNP
rs1411690740 3482 dbSNP
rs1475036485 3483 dbSNP
rs1165917861 3485 dbSNP
rs1420475102 3488 dbSNP
rs540008534 3489 dbSNP
rs1455919328 3490 dbSNP
rs1409506857 3493 dbSNP
rs921601566 3494 dbSNP
rs1318271366 3498 dbSNP
rs974088556 3500 dbSNP
rs573115471 3511 dbSNP
rs1376332558 3512 dbSNP
rs908056179 3514 dbSNP
rs547899460 3516 dbSNP
rs981885656 3527 dbSNP
rs970848809 3531 dbSNP
rs182040823 3534 dbSNP
rs1392800086 3535 dbSNP
rs970806636 3543 dbSNP
rs1020714101 3547 dbSNP
rs560922847 3553 dbSNP
rs1241334053 3554 dbSNP
rs1235870521 3555 dbSNP
rs1025106098 3556 dbSNP
rs543078684 3559 dbSNP
rs1009763693 3561 dbSNP
rs1213516344 3561 dbSNP
rs200939331 3563 dbSNP
rs990910334 3567 dbSNP
rs1448711718 3568 dbSNP
rs1471831286 3573 dbSNP
rs775316806 3574 dbSNP
rs140165957 3579 dbSNP
rs1409149434 3587 dbSNP
rs1403016778 3589 dbSNP
rs1000541108 3592 dbSNP
rs1373101213 3593 dbSNP
rs557536815 3594 dbSNP
rs1020082649 3600 dbSNP
rs1009986602 3602 dbSNP
rs890284424 3603 dbSNP
rs1356932561 3604 dbSNP
rs1439542079 3606 dbSNP
rs899836530 3608 dbSNP
rs1041411733 3610 dbSNP
rs1051488331 3615 dbSNP
rs371577709 3619 dbSNP
rs931731104 3622 dbSNP
rs944047257 3635 dbSNP
rs1433491920 3637 dbSNP
rs900184358 3638 dbSNP
rs1211634775 3648 dbSNP
rs1282522969 3648 dbSNP
rs1482226221 3651 dbSNP
rs539113951 3655 dbSNP
rs1047115831 3656 dbSNP
rs879711435 3660 dbSNP
rs942283506 3661 dbSNP
rs908083572 3662 dbSNP
rs983699056 3667 dbSNP
rs771786988 3669 dbSNP
rs1173769769 3670 dbSNP
rs1433597527 3670 dbSNP
rs1433449885 3684 dbSNP
rs1376727573 3686 dbSNP
rs1418498614 3688 dbSNP
rs1407926991 3689 dbSNP
rs1327688957 3690 dbSNP
rs918079734 3699 dbSNP
rs1444040677 3706 dbSNP
rs571609175 3707 dbSNP
rs1263740441 3708 dbSNP
rs1370206348 3714 dbSNP
rs553533447 3723 dbSNP
rs1210104555 3725 dbSNP
rs189692024 3726 dbSNP
rs926315956 3732 dbSNP
rs1337529798 3735 dbSNP
rs1282615067 3742 dbSNP
rs527352234 3746 dbSNP
rs979423493 3758 dbSNP
rs1307194302 3762 dbSNP
rs1252729452 3768 dbSNP
rs970402130 3772 dbSNP
rs766242816 3776 dbSNP
rs1196046359 3778 dbSNP
rs185229249 3783 dbSNP
rs549247027 3789 dbSNP
rs1166982729 3793 dbSNP
rs1419735944 3800 dbSNP
rs1411262544 3806 dbSNP
rs1323700862 3812 dbSNP
rs958212724 3817 dbSNP
rs1441634756 3825 dbSNP
rs1032474039 3835 dbSNP
rs1324780015 3848 dbSNP
rs1020198103 3849 dbSNP
rs1010094820 3852 dbSNP
rs761951654 3855 dbSNP
rs890310525 3857 dbSNP
rs1271024740 3859 dbSNP
rs1341784640 3862 dbSNP
rs535869454 3865 dbSNP
rs1273022447 3871 dbSNP
rs115184009 3879 dbSNP
rs900213689 3880 dbSNP
rs1246671010 3894 dbSNP
rs1019860620 3903 dbSNP
rs1191895214 3907 dbSNP
rs1037774941 3908 dbSNP
rs1476224197 3910 dbSNP
rs550123091 3915 dbSNP
rs1162346520 3921 dbSNP
rs147776974 3925 dbSNP
rs564802979 3933 dbSNP
rs1047146018 3941 dbSNP
rs1382646330 3944 dbSNP
rs546789629 3950 dbSNP
rs1381549215 3953 dbSNP
rs1314226374 3959 dbSNP
rs748793054 3965 dbSNP
rs1466218030 3969 dbSNP
rs1353629428 3972 dbSNP
rs774267277 3999 dbSNP
rs1328269388 4005 dbSNP
rs1413171493 4010 dbSNP
rs1292840116 4011 dbSNP
rs1335942391 4019 dbSNP
rs1235477248 4022 dbSNP
rs560104347 4033 dbSNP
rs918110390 4036 dbSNP
rs1055271949 4040 dbSNP
rs144165872 4041 dbSNP
rs114726342 4043 dbSNP
rs979922494 4048 dbSNP
rs1329123534 4056 dbSNP
rs1488948600 4058 dbSNP
rs966716158 4060 dbSNP
rs1256310641 4064 dbSNP
rs542939718 4074 dbSNP
rs1189852092 4079 dbSNP
rs1187101590 4080 dbSNP
rs1385674156 4081 dbSNP
rs1361829073 4087 dbSNP
rs148640437 4090 dbSNP
rs954598948 4103 dbSNP
rs1030586590 4104 dbSNP
rs937851361 4108 dbSNP
rs995983059 4117 dbSNP
rs926556925 4127 dbSNP
rs1432890461 4131 dbSNP
rs1312526988 4134 dbSNP
rs964897362 4135 dbSNP
rs1356378391 4140 dbSNP
rs1259692768 4141 dbSNP
rs1016047356 4148 dbSNP
rs563682312 4149 dbSNP
rs1240397766 4161 dbSNP
rs183806626 4165 dbSNP
rs192409143 4167 dbSNP
rs1047406261 4175 dbSNP
rs1278954947 4185 dbSNP
rs1485823706 4186 dbSNP
rs1183226673 4188 dbSNP
rs1248153324 4189 dbSNP
rs957742231 4194 dbSNP
rs553156270 4198 dbSNP
rs1452467118 4199 dbSNP
rs1173146131 4207 dbSNP
rs896707422 4207 dbSNP
rs1376129729 4212 dbSNP
rs1436886992 4220 dbSNP
rs1296601485 4228 dbSNP
rs1396245409 4230 dbSNP
rs976028487 4231 dbSNP
rs777876331 4232 dbSNP
rs1369485947 4233 dbSNP
rs1020311898 4238 dbSNP
rs1302134475 4240 dbSNP
rs1347885832 4242 dbSNP
rs1337655011 4254 dbSNP
rs1055704813 4266 dbSNP
rs186634540 4267 dbSNP
rs938232930 4268 dbSNP
rs752035703 4273 dbSNP
rs925436019 4285 dbSNP
rs1395774525 4287 dbSNP
rs1043840398 4309 dbSNP
rs1443978712 4325 dbSNP
rs945439802 4333 dbSNP
rs1164028361 4334 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000299138.7 | 3UTR | UUUCCCAUUUCUUACCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer -0.491 7.4e-3 -0.422 2.0e-2 24 Click to see details
GSE38226 Liver fibrosis 0.48 1.4e-2 0.458 1.8e-2 21 Click to see details
GSE19350 CNS germ cell tumors -0.51 4.5e-2 0.019 4.8e-1 12 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.296 1.0e-1 0.009 4.8e-1 20 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.261 1.0e-1 -0.368 3.5e-2 25 Click to see details
GSE17498 Multiple myeloma 0.186 1.3e-1 0.042 4.0e-1 40 Click to see details
GSE26953 Aortic valvular endothelial cells -0.221 1.5e-1 -0.239 1.3e-1 24 Click to see details
GSE21687 Ependynoma primary tumors -0.12 1.7e-1 -0.080 2.6e-1 64 Click to see details
GSE28260 Renal cortex and medulla 0.223 2.3e-1 0.202 2.5e-1 13 Click to see details
GSE32688 Pancreatic cancer 0.09 3.1e-1 -0.088 3.2e-1 32 Click to see details
GSE42095 Differentiated embryonic stem cells 0.06 3.9e-1 0.016 4.7e-1 23 Click to see details
GSE42095 Differentiated embryonic stem cells 0.06 3.9e-1 0.016 4.7e-1 23 Click to see details
GSE42095 Differentiated embryonic stem cells 0.06 3.9e-1 0.016 4.7e-1 23 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
PRAD -0.694 0 -0.600 0.01 14 Click to see details
LIHC 0.566 0.01 -0.029 0.46 17 Click to see details
LUSC 0.898 0.05 0.800 0.1 4 Click to see details
HNSC -0.389 0.15 -0.300 0.22 9 Click to see details
BRCA -0.889 0.15 -1.000 0.5 3 Click to see details
THCA 0.138 0.24 0.184 0.17 29 Click to see details
KICH 0.244 0.25 0.418 0.11 10 Click to see details
UCEC -0.182 0.35 -0.071 0.44 7 Click to see details
KIRP -0.151 0.35 -0.100 0.4 9 Click to see details
STAD 0.125 0.42 0.300 0.31 5 Click to see details
KIRC -0.022 0.46 -0.009 0.49 19 Click to see details
KIRC -0.022 0.46 -0.009 0.49 19 Click to see details
KIRC -0.022 0.46 -0.009 0.49 19 Click to see details
KIRC -0.022 0.46 -0.009 0.49 19 Click to see details
KIRC -0.022 0.46 -0.009 0.49 19 Click to see details
59 hsa-miR-499a-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT130131 TXNIP thioredoxin interacting protein 2 2
MIRT133678 ETNK1 ethanolamine kinase 1 2 2
MIRT252103 NAPG NSF attachment protein gamma 2 2
MIRT260160 IGFBP4 insulin like growth factor binding protein 4 2 2
MIRT388009 DR1 down-regulator of transcription 1 2 2
MIRT441692 ABLIM1 actin binding LIM protein 1 2 6
MIRT447799 EPC2 enhancer of polycomb homolog 2 2 2
MIRT450657 STYX serine/threonine/tyrosine interacting protein 2 4
MIRT456843 ZNF460 zinc finger protein 460 2 2
MIRT464134 VPS35 VPS35, retromer complex component 2 2
MIRT465101 TSC22D3 TSC22 domain family member 3 2 4
MIRT470051 PTGFRN prostaglandin F2 receptor inhibitor 2 2
MIRT474146 LIMA1 LIM domain and actin binding 1 2 6
MIRT474153 LIFR LIF receptor alpha 2 2
MIRT485327 MYO1D myosin ID 2 2
MIRT496403 ZSCAN16 zinc finger and SCAN domain containing 16 2 2
MIRT497280 MAF MAF bZIP transcription factor 2 2
MIRT500970 SPTSSA serine palmitoyltransferase small subunit A 2 2
MIRT501536 POM121C POM121 transmembrane nucleoporin C 2 6
MIRT505174 WDR76 WD repeat domain 76 2 4
MIRT505203 UQCRB ubiquinol-cytochrome c reductase binding protein 2 4
MIRT506745 LIN54 lin-54 DREAM MuvB core complex component 2 4
MIRT506799 KLHL15 kelch like family member 15 2 6
MIRT525718 DCAF12L2 DDB1 and CUL4 associated factor 12 like 2 2 2
MIRT530014 SRRM1 serine and arginine repetitive matrix 1 2 2
MIRT531457 PROSER2 proline and serine rich 2 2 2
MIRT532272 CD93 CD93 molecule 2 2
MIRT538715 CAPRIN2 caprin family member 2 2 4
MIRT547356 NAT8L N-acetyltransferase 8 like 2 2
MIRT551468 TRIM59 tripartite motif containing 59 2 2
MIRT555444 NT5C3A 5'-nucleotidase, cytosolic IIIA 2 2
MIRT555674 PGAM4 phosphoglycerate mutase family member 4 2 4
MIRT557816 FOXO1 forkhead box O1 2 2
MIRT557853 FIGN fidgetin, microtubule severing factor 2 2
MIRT557880 FEM1B fem-1 homolog B 2 4
MIRT562299 GLO1 glyoxalase I 2 2
MIRT563245 QRFPR pyroglutamylated RFamide peptide receptor 2 2
MIRT565571 SLC7A2 solute carrier family 7 member 2 2 2
MIRT566214 PTMA prothymosin, alpha 2 2
MIRT575544 Map4 microtubule-associated protein 4 2 2
MIRT609316 FXYD6 FXYD domain containing ion transport regulator 6 2 2
MIRT609362 ACOT2 acyl-CoA thioesterase 2 2 2
MIRT611163 BTLA B and T lymphocyte associated 2 4
MIRT611749 CACNA1B calcium voltage-gated channel subunit alpha1 B 2 2
MIRT615019 ELK4 ELK4, ETS transcription factor 2 2
MIRT623317 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT624550 BMPR1A bone morphogenetic protein receptor type 1A 2 2
MIRT633934 DNAH9 dynein axonemal heavy chain 9 2 2
MIRT635691 BMP10 bone morphogenetic protein 10 2 2
MIRT646438 DNAH8 dynein axonemal heavy chain 8 2 2
MIRT651940 UBN1 ubinuclein 1 2 2
MIRT663605 TBC1D22A TBC1 domain family member 22A 2 2
MIRT689759 PRR13 proline rich 13 2 2
MIRT691916 SRXN1 sulfiredoxin 1 2 2
MIRT698678 TEF TEF, PAR bZIP transcription factor 2 2
MIRT700924 PDS5A PDS5 cohesin associated factor A 2 2
MIRT707970 PDE12 phosphodiesterase 12 2 2
MIRT715290 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT722414 RARS2 arginyl-tRNA synthetase 2, mitochondrial 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-499a Erlotinib 176870 NSC718781 approved sensitive Low Osteosarcoma cell line (CD166)
hsa-mir-499a Cisplatin 5460033 NSC119875 approved resistant Low Cervical Cancer cell line (GH329, Hela, CaSki, Siha)
hsa-miR-499a-3p Trametinib 11707110 NSC758246 approved sensitive High Melanoma cell line (M14) (2uM)
hsa-miR-499a-3p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (M14) (2uM)
hsa-miR-499a-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-499a-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-499a-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-499a-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM47)
hsa-miR-499a-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-499a-3p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-499a-3p Cisplatin 5460033 NSC119875 approved resistant cell line (RPMI2650)
hsa-miR-499a-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-499a-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-499a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

Error report submission