miRTarBase - #MIRT464207


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pre-miRNA Information
pre-miRNA hsa-mir-3529   
Genomic Coordinates chr15: 88611847 - 88611924
Description Homo sapiens miR-3529 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3529-5p
Sequence 10| AGGUAGACUGGGAUUUGUUGUU |31
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs747160976 1 dbSNP
rs777738449 2 dbSNP
rs1421978871 4 dbSNP
rs1167726772 6 dbSNP
rs1355306872 6 dbSNP
rs1286285953 7 dbSNP
rs1233166293 8 dbSNP
rs772151253 9 dbSNP
rs1204890571 13 dbSNP
rs1250455629 18 dbSNP
rs748388180 19 dbSNP
rs1303070972 21 dbSNP
Putative Targets

Gene Information
Gene Symbol VGLL4   
Synonyms VGL-4
Description vestigial like family member 4
Transcript NM_001128219   
Other Transcripts NM_001128220 , NM_001128221 , NM_014667   
Expression
Putative miRNA Targets on VGLL4
3'UTR of VGLL4
(miRNA target sites are highlighted)		 
>VGLL4|NM_001128219|3'UTR
   1 AGGGAGCGCCTCCTCCAACAACACGTGGATCTGCATGGTTTGCCTGAGCTTTGAACAGTCAGTACTTAAAAAAAAAAAAA
  81 TCATGGGGGTGGGGTGGGGGGAAGGGAAGGGATGGTTTATTTGCAAAAACCATGTTGTTGGGATTTGTGTTCTGTTTTTG
 161 TACTTGCTTGGTATCCGTACAAGGGGGCCCTCAAACATGATAGCAGGAACTACGCGTGGAACATCTGTCTAATGTAGCAT
 241 CCTTACTTCCTGCCTCAGTTACCAAAGAAACCTCTGATGCAGGTCTGCTGCCCCGACGGGGCCAGGACTCCACAGCGCTT
 321 TCTCAGTCACAAGCCATGATGAATTGGTGACTCAGACGCTTTGTGCTTTTTCCTTTGCTTCTTGAGACCGGGGTGTGTGT
 401 GGCTCAGCTTCCACGGCGTGTTTGGTTCGGTCCATGTGTGTGCGTGTGTATACTTGAAGAGAACTGTCGTGTCTGATTTG
 481 CACTATTGGAGGAGGACTAAAGTTGCCTGACAACTTTATGTGTTATGCCAGAACTCTGAGGGCAAACTGCTGAAAAACAA
 561 AGGGTTTAAGGATGACATTTCTGACCATTTGTGTGTTTGTTGTTGTTACTGTTTTTGTTTTTTTTAATGTAGACAATACA
 641 GCTTTGGAAGGGGAAGTCTCATACAGGTTATAGGTCTTTCTCTCTCTAGATTTCAGGTGCTTGCAACTGGACTGCAGACT
 721 CTACCAATCACGGGCATTTTATCTTCTCTGAACACTGCAGTTTGTTAGACTAGAGCTGAGGTTGGAGGATTCCATAGTGC
 801 TTTAAACGTGATGCATGTTTTAATGGAGAAAAAATAGCTGGTTTCTATTAATTATATAGACAGTAAACAAAAACCTTAAT
 881 ACTTACTATCTTCTTTTCAGAATTAGTTTATTTTTGTCAGTTACAGTCCTAGATATACTTACTGCTGGTACAGTTGTACT
 961 CTAAGATTGGTATTTGATATTCACTTTACTCACAAGTAGTGCGGGAGGCCAGCTCCTGGCAGGCCCTCGCGATGAGCAGT
1041 GGGTCAGCTGCGGTGTGGGATGCTGGAGTTTGGCTGCAGGCTGACATCATTTATTTTTGCATCCCTGTCTGCTTTGTTAC
1121 AAGCTCCCAGGGGAGGTGGGGTTTGTGTCTTCCAACTTCCCTACATGCAGAAACTGCTCCCTTTGAACTCTCTTGGCTGA
1201 ACAGCAGATTACTGACAGACAATCTGTGATATGGTGTTTTATACGCTTCCTCGTACGCTGGGGCCAAGGCAGTATACATT
1281 CCTCTGACTTTATACTGTTATTACTGCATTTATTATTTGCTATATTAATAGCTACTAACTAGAAATTAGATGAAGCAAGC
1361 ATGACAGACACAGCTGTGGAGGTCACAGCTGCTCCTTTTTGGTCAATGAGCGTTTCTATCCCCTCCCCCTGGGGTGTGCT
1441 GTGTCCCACCTGGCCCACCAGAGGCTCACGACGATGGCACCTGACCAGGTGACGTGGGCGTGGTCACCTCACCTGCAAGG
1521 CTTTGTGGACTCTGCACACCGTATGACCCCCGGTTTTACAGTTTTTAGCTGTTGAATTTTGGAAATTGGCACTGGGTGAA
1601 AAGGTCGGAGGACTGGCTCTTGTAGTCACAGAGTGGCTGCAGGCCTTTGAAAAGTGGAGGAAAGAAAAGCCCTTCTCCTT
1681 GCCCCGCACACATTTCACTCCCACTGTACTGGGCTTCCAAGCTTTGGCATTCAGGCCCCTATATTTTCTGTAGGAAAAAT
1761 CGTTGAGAACACTTTTCTATATGGGTGATTTTGAGACCATCGTTACGCTGTGCGTAAAGAATGTACAGAGAAATTTGTAG
1841 GTATTTTTTGAAGAACATTAATTTGTTAATGATATGTAGCTATTTAATTTTTCCCTTTCCTATTGTAATCATTCATTTTT
1921 TTTGTTGTTCGGAAAAAAAAAGTTGATCTTTTTTTTTGTCGTAGATTTGTCTGTAAAAGTGCAGGAACAGTTATTCTATG
2001 AGAACACTGCATCTGCATTCATAGCCACGAGTTTGTTATTGCTACAGGCTACTGAGCGTCGTAACAGGAAAACCACCCAC
2081 AGCTGACCGGCTCGGTGGAGGACACTCCTGGGACAGGTCTCTTTGTCAGTGAACAAGGGCGTCACTCTGGGAGGGGTCGG
2161 CGGTGCTGGCGGCCGGGTCCCTGGTGCACTGACCTATCTGGGATAGGCAGTACCCTGGAGGGGGGCCTGGGGCAGAGGAG
2241 GCAGCAGAAAACCAAACATTTCACTGAGAAAGCCCCCTCCCTGCTCTAAGAAGGGGCTCCGTGAAGTTCTTCCCAGAGCC
2321 GCGCTGCCTGCAGTGCGCTCTGACCTTCTCTTCATGTGTGTAAATCTGTAATATACCATTCTCTGTGGCCTGTTTTTCCT
2401 GGAAGAAGAAAAAAAAAGGTTTGGCAGGCCATCTTTTTTTGTACTTAAAAGTAGCCTTAAGAACAATAATAAAGTGCTCT
2481 TAAACCACAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uuguuguuUAGGGUCAGAUGGa 5'
                  ||||| ||||:|: 
Target 5' atttttgcATCCCTGTCTGCTt 3'
 1093 - 1114 130.00 -17.40
2 
miRNA  3' uuGUUGU----UUAGG-GU--CAGAUGGa 5'
            |||||    :|||: ||  ||:|:|| 
Target 5' aaCAACACGTGGATCTGCATGGTTTGCCt 3'
 17 - 45 128.00 -14.90
3 
miRNA  3' uuGUUG-UUUAGGGUC--AGAUGGa 5'
            |||| ::| : |||  |||||| 
Target 5' tgCAACTGGACTGCAGACTCTACCa 3'
 702 - 726 124.00 -13.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30452650 2 COSMIC
COSN30487777 4 COSMIC
COSN24382427 8 COSMIC
COSN20098109 67 COSMIC
COSN15666739 68 COSMIC
COSN20090766 95 COSMIC
COSN20064864 96 COSMIC
COSN19420700 121 COSMIC
COSN21230116 192 COSMIC
COSN30175756 215 COSMIC
COSN24300147 216 COSMIC
COSN31483032 295 COSMIC
COSN23039832 354 COSMIC
COSN26646790 617 COSMIC
COSN31484960 724 COSMIC
COSN31522993 954 COSMIC
COSN31533149 1272 COSMIC
COSN30161853 1292 COSMIC
COSN31549895 1360 COSMIC
COSN20720486 1412 COSMIC
COSN31513127 1500 COSMIC
COSN31562063 1686 COSMIC
COSN31522243 1762 COSMIC
COSN1908442 1820 COSMIC
COSN15725059 1885 COSMIC
COSN1265674 1949 COSMIC
COSN31571562 1956 COSMIC
COSN30176516 1960 COSMIC
COSN31518695 1980 COSMIC
COSN31536878 2037 COSMIC
COSN26649544 2087 COSMIC
COSN31962017 2162 COSMIC
COSN31536432 2164 COSMIC
COSN30542406 2214 COSMIC
COSN6571068 2218 COSMIC
COSN31548999 2363 COSMIC
COSN20703596 2380 COSMIC
COSN31566091 2439 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs199701475 7 dbSNP
rs370862899 8 dbSNP
rs776006826 11 dbSNP
rs1189928849 13 dbSNP
rs200385499 18 dbSNP
rs1432199806 19 dbSNP
rs968206952 21 dbSNP
rs1301228010 22 dbSNP
rs201152887 24 dbSNP
rs757854006 24 dbSNP
rs759990697 25 dbSNP
rs774960701 29 dbSNP
rs1158673106 30 dbSNP
rs1455796620 31 dbSNP
rs771318836 42 dbSNP
rs1388471088 49 dbSNP
rs143606016 50 dbSNP
rs1322637894 56 dbSNP
rs1254669982 57 dbSNP
rs1365818515 58 dbSNP
rs1386444627 61 dbSNP
rs542555092 61 dbSNP
rs955509020 64 dbSNP
rs1483404206 65 dbSNP
rs1254281566 66 dbSNP
rs1203223970 67 dbSNP
rs1267495333 68 dbSNP
rs1329776611 68 dbSNP
rs1341208541 78 dbSNP
rs1030074688 81 dbSNP
rs1268935437 81 dbSNP
rs1270701917 81 dbSNP
rs1361051526 81 dbSNP
rs1435290029 81 dbSNP
rs369629845 81 dbSNP
rs561287742 81 dbSNP
rs900382937 81 dbSNP
rs996892023 81 dbSNP
rs1348239054 82 dbSNP
rs1292142680 83 dbSNP
rs979292945 84 dbSNP
rs1393133065 85 dbSNP
rs575356624 86 dbSNP
rs879602170 90 dbSNP
rs1223888072 94 dbSNP
rs879786287 95 dbSNP
rs1038953549 96 dbSNP
rs1320592705 99 dbSNP
rs1006034461 100 dbSNP
rs1305817294 100 dbSNP
rs1408770043 105 dbSNP
rs1365806544 106 dbSNP
rs1294545954 109 dbSNP
rs1266898647 113 dbSNP
rs1479451525 113 dbSNP
rs1459750606 114 dbSNP
rs1367275695 119 dbSNP
rs1164641251 120 dbSNP
rs1472971482 126 dbSNP
rs35743963 130 dbSNP
rs887622060 130 dbSNP
rs1180291151 132 dbSNP
rs553095730 147 dbSNP
rs1412190140 152 dbSNP
rs1261149607 153 dbSNP
rs1423381340 154 dbSNP
rs929019418 158 dbSNP
rs1000494146 160 dbSNP
rs1428045483 166 dbSNP
rs1056502750 167 dbSNP
rs1370969329 173 dbSNP
rs937697472 176 dbSNP
rs1301024325 177 dbSNP
rs1378327428 177 dbSNP
rs556880251 197 dbSNP
rs1027970078 204 dbSNP
rs1339694769 207 dbSNP
rs188306508 214 dbSNP
rs539097787 215 dbSNP
rs571668361 216 dbSNP
rs1036706543 221 dbSNP
rs1241088646 223 dbSNP
rs1483193356 231 dbSNP
rs1182573452 232 dbSNP
rs1416074511 233 dbSNP
rs553540722 234 dbSNP
rs955635455 246 dbSNP
rs1390954858 251 dbSNP
rs1431459287 253 dbSNP
rs1173688687 254 dbSNP
rs1358545689 262 dbSNP
rs1448642572 265 dbSNP
rs779048426 271 dbSNP
rs1302917500 272 dbSNP
rs1388918734 276 dbSNP
rs1029754778 280 dbSNP
rs1049215370 281 dbSNP
rs1297955877 285 dbSNP
rs370926057 287 dbSNP
rs1216733269 290 dbSNP
rs1276923602 292 dbSNP
rs1311930808 294 dbSNP
rs36111966 295 dbSNP
rs930913125 295 dbSNP
rs7355828 297 dbSNP
rs1044448586 298 dbSNP
rs949995292 304 dbSNP
rs917343053 309 dbSNP
rs1451523757 313 dbSNP
rs1391460051 316 dbSNP
rs567702089 317 dbSNP
rs1006127787 319 dbSNP
rs1472291557 324 dbSNP
rs753687381 331 dbSNP
rs887715417 332 dbSNP
rs1047590239 336 dbSNP
rs1433883080 338 dbSNP
rs1431245743 347 dbSNP
rs925808876 357 dbSNP
rs978600896 358 dbSNP
rs1209116838 359 dbSNP
rs549655894 365 dbSNP
rs1266143991 372 dbSNP
rs766028848 380 dbSNP
rs879550655 385 dbSNP
rs531231109 389 dbSNP
rs570616053 390 dbSNP
rs757520878 392 dbSNP
rs1197030362 394 dbSNP
rs551697256 395 dbSNP
rs1478267647 403 dbSNP
rs751691686 412 dbSNP
rs1004397059 414 dbSNP
rs888183731 415 dbSNP
rs185535419 417 dbSNP
rs1390249394 418 dbSNP
rs914190150 425 dbSNP
rs558544680 426 dbSNP
rs1049732053 428 dbSNP
rs995006372 429 dbSNP
rs955569687 430 dbSNP
rs1349234279 434 dbSNP
rs1228341904 436 dbSNP
rs1289481840 442 dbSNP
rs558479644 443 dbSNP
rs7614588 444 dbSNP
rs1289519079 446 dbSNP
rs1452375273 450 dbSNP
rs1803492 455 dbSNP
rs950052533 458 dbSNP
rs1249381714 461 dbSNP
rs1174541587 464 dbSNP
rs1182812612 464 dbSNP
rs1365405539 465 dbSNP
rs964504144 466 dbSNP
rs1016925758 468 dbSNP
rs984158526 469 dbSNP
rs1406717717 471 dbSNP
rs951932126 478 dbSNP
rs917227287 482 dbSNP
rs1409534542 485 dbSNP
rs866250546 486 dbSNP
rs1338043717 491 dbSNP
rs1377275788 493 dbSNP
rs1026241112 495 dbSNP
rs1248478446 497 dbSNP
rs772261668 497 dbSNP
rs934766311 499 dbSNP
rs1272661253 503 dbSNP
rs143719167 507 dbSNP
rs1346347954 511 dbSNP
rs896335258 514 dbSNP
rs760342121 515 dbSNP
rs1186290837 517 dbSNP
rs1246152262 517 dbSNP
rs1445879747 518 dbSNP
rs979037338 518 dbSNP
rs1187795173 520 dbSNP
rs1429589014 521 dbSNP
rs1001943423 522 dbSNP
rs1442506417 523 dbSNP
rs537504419 526 dbSNP
rs1394822456 528 dbSNP
rs532658655 543 dbSNP
rs921183390 544 dbSNP
rs1341143025 548 dbSNP
rs1454598201 549 dbSNP
rs1198223358 550 dbSNP
rs1341721594 551 dbSNP
rs1228923768 552 dbSNP
rs1252832906 553 dbSNP
rs1342554259 554 dbSNP
rs182313607 556 dbSNP
rs1462312474 562 dbSNP
rs542467251 562 dbSNP
rs774975203 562 dbSNP
rs1043365380 563 dbSNP
rs1015236599 565 dbSNP
rs1344701320 578 dbSNP
rs946393395 588 dbSNP
rs1296064847 589 dbSNP
rs1430561687 591 dbSNP
rs1407463326 595 dbSNP
rs892680444 596 dbSNP
rs1364799141 597 dbSNP
rs147906293 597 dbSNP
rs376282056 597 dbSNP
rs1297948157 599 dbSNP
rs190216412 599 dbSNP
rs1232186698 600 dbSNP
rs1329141194 600 dbSNP
rs1256586275 602 dbSNP
rs1325553429 602 dbSNP
rs952602460 603 dbSNP
rs1384685138 608 dbSNP
rs1464921654 608 dbSNP
rs1401821546 611 dbSNP
rs748498181 614 dbSNP
rs1026698909 617 dbSNP
rs369417745 617 dbSNP
rs532493658 617 dbSNP
rs1431420608 621 dbSNP
rs1388025006 623 dbSNP
rs774897542 626 dbSNP
rs1157527078 630 dbSNP
rs769101043 637 dbSNP
rs942795354 646 dbSNP
rs1290868535 651 dbSNP
rs149366792 652 dbSNP
rs906010113 662 dbSNP
rs1386045641 664 dbSNP
rs1283658219 674 dbSNP
rs1347106230 678 dbSNP
rs147674636 688 dbSNP
rs371418568 688 dbSNP
rs527873758 688 dbSNP
rs531867006 688 dbSNP
rs1329246661 689 dbSNP
rs1056994 694 dbSNP
rs1044684127 706 dbSNP
rs1487939075 711 dbSNP
rs780051389 715 dbSNP
rs1209673881 716 dbSNP
rs1270083092 717 dbSNP
rs951380828 720 dbSNP
rs750304307 723 dbSNP
rs1184842586 724 dbSNP
rs1419807917 728 dbSNP
rs1161340203 729 dbSNP
rs1441303004 731 dbSNP
rs971994379 732 dbSNP
rs1014545448 746 dbSNP
rs544863289 750 dbSNP
rs1053569041 753 dbSNP
rs904918160 754 dbSNP
rs1307400840 762 dbSNP
rs1484244437 763 dbSNP
rs576886185 767 dbSNP
rs1225012507 773 dbSNP
rs1376454240 780 dbSNP
rs1214337112 781 dbSNP
rs1022003499 782 dbSNP
rs1245108337 785 dbSNP
rs1010504211 786 dbSNP
rs1803491 788 dbSNP
rs1362058281 793 dbSNP
rs1357740139 794 dbSNP
rs892145451 794 dbSNP
rs1286440532 799 dbSNP
rs879244123 808 dbSNP
rs1481233253 813 dbSNP
rs756208951 814 dbSNP
rs1179410704 815 dbSNP
rs759981054 817 dbSNP
rs185271223 823 dbSNP
rs1354851602 825 dbSNP
rs553493518 826 dbSNP
rs1164465251 829 dbSNP
rs1052558967 835 dbSNP
rs777079574 840 dbSNP
rs1411824367 841 dbSNP
rs1167698699 849 dbSNP
rs934671416 850 dbSNP
rs117140049 852 dbSNP
rs904614359 854 dbSNP
rs1355096463 855 dbSNP
rs879586113 855 dbSNP
rs1300972577 857 dbSNP
rs771163414 858 dbSNP
rs1377815684 864 dbSNP
rs1452657464 865 dbSNP
rs1316785630 868 dbSNP
rs1362577689 873 dbSNP
rs1226709482 882 dbSNP
rs116096788 886 dbSNP
rs1308405199 887 dbSNP
rs1254709663 888 dbSNP
rs901460048 888 dbSNP
rs1482998602 889 dbSNP
rs1039863789 891 dbSNP
rs756937582 892 dbSNP
rs374501135 894 dbSNP
rs1415925031 899 dbSNP
rs1161349250 901 dbSNP
rs942868104 905 dbSNP
rs1480459596 907 dbSNP
rs1016481861 910 dbSNP
rs984220833 910 dbSNP
rs1173888264 914 dbSNP
rs764039424 916 dbSNP
rs1469929539 919 dbSNP
rs921124625 921 dbSNP
rs537715092 931 dbSNP
rs1362336564 932 dbSNP
rs943996188 934 dbSNP
rs908457065 936 dbSNP
rs982862231 956 dbSNP
rs952371415 957 dbSNP
rs1216674435 965 dbSNP
rs370458878 965 dbSNP
rs993278182 970 dbSNP
rs1204447023 977 dbSNP
rs1183710532 979 dbSNP
rs570236737 980 dbSNP
rs1250589922 987 dbSNP
rs1204319373 989 dbSNP
rs980520234 993 dbSNP
rs960649920 995 dbSNP
rs1189244810 996 dbSNP
rs969116449 1002 dbSNP
rs552077876 1003 dbSNP
rs1452513690 1009 dbSNP
rs1292672990 1013 dbSNP
rs1385809890 1013 dbSNP
rs1014430860 1015 dbSNP
rs1318626740 1025 dbSNP
rs753012156 1027 dbSNP
rs539640103 1028 dbSNP
rs969211884 1029 dbSNP
rs1031890487 1031 dbSNP
rs1289135033 1034 dbSNP
rs1327182098 1041 dbSNP
rs1021971307 1047 dbSNP
rs999265016 1051 dbSNP
rs1230282983 1052 dbSNP
rs1348916344 1053 dbSNP
rs1803490 1055 dbSNP
rs904499587 1058 dbSNP
rs1490432751 1061 dbSNP
rs1279155573 1068 dbSNP
rs1043437185 1072 dbSNP
rs771832992 1074 dbSNP
rs1436968270 1081 dbSNP
rs1351353054 1089 dbSNP
rs1321515114 1096 dbSNP
rs1158604687 1097 dbSNP
rs565975247 1100 dbSNP
rs879745143 1103 dbSNP
rs1322426598 1106 dbSNP
rs998291843 1107 dbSNP
rs1160808876 1109 dbSNP
rs747723557 1111 dbSNP
rs1305552626 1112 dbSNP
rs1471309499 1113 dbSNP
rs1040890204 1116 dbSNP
rs1441619336 1116 dbSNP
rs546249318 1120 dbSNP
rs778496831 1122 dbSNP
rs1280188665 1124 dbSNP
rs982694820 1126 dbSNP
rs528177011 1129 dbSNP
rs1226826936 1130 dbSNP
rs1291236243 1139 dbSNP
rs1487793861 1143 dbSNP
rs1224434025 1144 dbSNP
rs1249575468 1149 dbSNP
rs1437136689 1151 dbSNP
rs1191368297 1163 dbSNP
rs1040361311 1164 dbSNP
rs547038533 1169 dbSNP
rs919633744 1173 dbSNP
rs1162556501 1178 dbSNP
rs980828405 1191 dbSNP
rs1385459713 1194 dbSNP
rs1425763325 1198 dbSNP
rs560519583 1212 dbSNP
rs1007036329 1217 dbSNP
rs969168695 1218 dbSNP
rs1330062433 1220 dbSNP
rs16340 1222 dbSNP
rs397831750 1222 dbSNP
rs930043974 1223 dbSNP
rs1314706496 1228 dbSNP
rs1210714406 1229 dbSNP
rs1247959862 1232 dbSNP
rs1024722664 1233 dbSNP
rs548587861 1244 dbSNP
rs960156803 1245 dbSNP
rs1440259647 1246 dbSNP
rs530564976 1252 dbSNP
rs1032358655 1253 dbSNP
rs563415421 1256 dbSNP
rs138724586 1257 dbSNP
rs927879678 1266 dbSNP
rs1021666387 1267 dbSNP
rs1169056160 1269 dbSNP
rs1399252767 1273 dbSNP
rs981109190 1274 dbSNP
rs1336132444 1278 dbSNP
rs1439864996 1279 dbSNP
rs1454807552 1281 dbSNP
rs1295595973 1282 dbSNP
rs534982826 1288 dbSNP
rs754977474 1291 dbSNP
rs1227876220 1292 dbSNP
rs996794401 1292 dbSNP
rs899934436 1297 dbSNP
rs771470628 1300 dbSNP
rs1202542855 1301 dbSNP
rs1263246607 1302 dbSNP
rs563592832 1306 dbSNP
rs1041067455 1307 dbSNP
rs989312424 1309 dbSNP
rs1260593576 1310 dbSNP
rs1428362199 1313 dbSNP
rs543804662 1315 dbSNP
rs1375332783 1321 dbSNP
rs1322418962 1324 dbSNP
rs956446696 1331 dbSNP
rs1031174985 1332 dbSNP
rs886915647 1336 dbSNP
rs997819932 1347 dbSNP
rs1047324913 1350 dbSNP
rs1384526110 1352 dbSNP
rs1017970549 1355 dbSNP
rs1320019623 1359 dbSNP
rs1455211722 1361 dbSNP
rs1329091252 1362 dbSNP
rs773548637 1362 dbSNP
rs1283782158 1364 dbSNP
rs1226035550 1367 dbSNP
rs1325138285 1367 dbSNP
rs1007131179 1369 dbSNP
rs1176336152 1373 dbSNP
rs749130482 1381 dbSNP
rs1206473074 1383 dbSNP
rs1415882419 1384 dbSNP
rs559590203 1389 dbSNP
rs1489941892 1390 dbSNP
rs879162554 1396 dbSNP
rs1199348745 1397 dbSNP
rs779929617 1401 dbSNP
rs1375737633 1402 dbSNP
rs1454083588 1410 dbSNP
rs1249222847 1411 dbSNP
rs931271397 1412 dbSNP
rs888741669 1416 dbSNP
rs541506267 1418 dbSNP
rs1463610561 1420 dbSNP
rs1363499732 1421 dbSNP
rs1404093470 1422 dbSNP
rs1241667226 1427 dbSNP
rs114200578 1429 dbSNP
rs376053228 1435 dbSNP
rs1044788793 1439 dbSNP
rs1314215278 1440 dbSNP
rs994346642 1441 dbSNP
rs947669222 1447 dbSNP
rs917676632 1454 dbSNP
rs1240747568 1455 dbSNP
rs1263259208 1459 dbSNP
rs938667201 1460 dbSNP
rs750219985 1469 dbSNP
rs764367995 1470 dbSNP
rs924827471 1472 dbSNP
rs555930754 1473 dbSNP
rs1419681967 1479 dbSNP
rs1006386378 1484 dbSNP
rs969030947 1485 dbSNP
rs1449549102 1486 dbSNP
rs1357104917 1487 dbSNP
rs1367150029 1492 dbSNP
rs537027805 1493 dbSNP
rs758549640 1494 dbSNP
rs1392616401 1495 dbSNP
rs1312552725 1498 dbSNP
rs923688488 1499 dbSNP
rs1171038861 1500 dbSNP
rs963987058 1501 dbSNP
rs576427998 1503 dbSNP
rs867309922 1504 dbSNP
rs976897031 1506 dbSNP
rs1203044477 1514 dbSNP
rs1008298210 1516 dbSNP
rs887175063 1523 dbSNP
rs1481038194 1525 dbSNP
rs549631900 1533 dbSNP
rs566109655 1534 dbSNP
rs781434902 1535 dbSNP
rs752789024 1537 dbSNP
rs985160083 1538 dbSNP
rs373367113 1539 dbSNP
rs150193137 1540 dbSNP
rs1027243748 1541 dbSNP
rs1334098571 1547 dbSNP
rs548069346 1548 dbSNP
rs375326913 1551 dbSNP
rs1213172841 1552 dbSNP
rs917560143 1552 dbSNP
rs1483264797 1561 dbSNP
rs551520797 1566 dbSNP
rs1276590596 1571 dbSNP
rs1035891158 1574 dbSNP
rs1225883527 1575 dbSNP
rs1261369701 1587 dbSNP
rs1204555938 1588 dbSNP
rs1460872421 1588 dbSNP
rs1245183904 1593 dbSNP
rs1056123849 1594 dbSNP
rs1003350761 1606 dbSNP
rs191606941 1607 dbSNP
rs1313302372 1612 dbSNP
rs1229567531 1614 dbSNP
rs935134688 1620 dbSNP
rs923677719 1622 dbSNP
rs1376284159 1623 dbSNP
rs1311908151 1627 dbSNP
rs1338370903 1630 dbSNP
rs1343039922 1631 dbSNP
rs893684508 1632 dbSNP
rs1288678742 1634 dbSNP
rs1372010256 1636 dbSNP
rs1221006441 1640 dbSNP
rs867275810 1642 dbSNP
rs1322991803 1647 dbSNP
rs1224202188 1650 dbSNP
rs1310293997 1651 dbSNP
rs9881151 1652 dbSNP
rs923753282 1656 dbSNP
rs976654251 1657 dbSNP
rs1242519746 1658 dbSNP
rs1486686118 1669 dbSNP
rs943778789 1674 dbSNP
rs1354501760 1680 dbSNP
rs746633249 1682 dbSNP
rs914842655 1682 dbSNP
rs534383588 1685 dbSNP
rs964248644 1686 dbSNP
rs532083410 1687 dbSNP
rs1019599629 1689 dbSNP
rs1402223845 1693 dbSNP
rs766890693 1695 dbSNP
rs985086735 1696 dbSNP
rs1345404360 1697 dbSNP
rs1187308397 1698 dbSNP
rs567008333 1700 dbSNP
rs1276716491 1702 dbSNP
rs796313318 1705 dbSNP
rs1348585231 1706 dbSNP
rs1223433995 1713 dbSNP
rs1254215270 1714 dbSNP
rs1193894106 1721 dbSNP
rs1480162249 1725 dbSNP
rs73812470 1726 dbSNP
rs1219973409 1737 dbSNP
rs1291008257 1738 dbSNP
rs1490499430 1739 dbSNP
rs1027211094 1741 dbSNP
rs995354913 1742 dbSNP
rs972967081 1745 dbSNP
rs1230678586 1748 dbSNP
rs767514099 1749 dbSNP
rs1177481811 1750 dbSNP
rs760998324 1755 dbSNP
rs898300582 1757 dbSNP
rs867640067 1761 dbSNP
rs530422684 1762 dbSNP
rs752495534 1763 dbSNP
rs1365292233 1768 dbSNP
rs1425884947 1770 dbSNP
rs1326034502 1773 dbSNP
rs1012200902 1779 dbSNP
rs1334072117 1784 dbSNP
rs896401460 1790 dbSNP
rs1292207412 1792 dbSNP
rs145976533 1793 dbSNP
rs1379367319 1800 dbSNP
rs905907855 1800 dbSNP
rs1243988819 1802 dbSNP
rs1314148686 1806 dbSNP
rs754690019 1807 dbSNP
rs1351992827 1813 dbSNP
rs1286029506 1814 dbSNP
rs1270777617 1822 dbSNP
rs1390055306 1823 dbSNP
rs934957481 1825 dbSNP
rs1239675893 1830 dbSNP
rs1442421839 1834 dbSNP
rs1182556234 1835 dbSNP
rs902262887 1839 dbSNP
rs1396159655 1843 dbSNP
rs765220541 1850 dbSNP
rs1473299830 1852 dbSNP
rs1165571719 1853 dbSNP
rs1394966619 1854 dbSNP
rs1043841002 1856 dbSNP
rs1329645724 1862 dbSNP
rs773617930 1863 dbSNP
rs1459960816 1872 dbSNP
rs1402495324 1874 dbSNP
rs1450724340 1874 dbSNP
rs1314560954 1875 dbSNP
rs1383330198 1876 dbSNP
rs1246711389 1877 dbSNP
rs1268382967 1877 dbSNP
rs914769012 1879 dbSNP
rs1392897377 1883 dbSNP
rs975536564 1889 dbSNP
rs747297831 1893 dbSNP
rs1164361257 1895 dbSNP
rs1457803180 1898 dbSNP
rs1414500912 1900 dbSNP
rs1179860458 1901 dbSNP
rs1418296931 1904 dbSNP
rs1267704182 1906 dbSNP
rs771853057 1911 dbSNP
rs1011506520 1912 dbSNP
rs1467121588 1913 dbSNP
rs771433120 1916 dbSNP
rs563302500 1917 dbSNP
rs565437662 1918 dbSNP
rs1171921087 1924 dbSNP
rs397966587 1924 dbSNP
rs61586366 1924 dbSNP
rs1425885858 1927 dbSNP
rs1237804709 1929 dbSNP
rs1468287039 1930 dbSNP
rs551337320 1930 dbSNP
rs1315989439 1931 dbSNP
rs999849234 1931 dbSNP
rs1302484957 1932 dbSNP
rs1431396604 1933 dbSNP
rs1279953508 1935 dbSNP
rs1388861726 1941 dbSNP
rs1320875536 1942 dbSNP
rs201810263 1942 dbSNP
rs1263419765 1945 dbSNP
rs1369477965 1946 dbSNP
rs1202956959 1949 dbSNP
rs542508272 1951 dbSNP
rs1446721479 1957 dbSNP
rs1265968480 1958 dbSNP
rs879799623 1958 dbSNP
rs902464181 1958 dbSNP
rs1175770842 1959 dbSNP
rs1378227190 1960 dbSNP
rs533275707 1960 dbSNP
rs114755647 1961 dbSNP
rs1383989417 1964 dbSNP
rs1400372539 1965 dbSNP
rs1300035185 1969 dbSNP
rs541211040 1971 dbSNP
rs1403854747 1972 dbSNP
rs1283400987 1979 dbSNP
rs1157051516 1985 dbSNP
rs1332250807 1988 dbSNP
rs1025746493 1994 dbSNP
rs1049518774 1994 dbSNP
rs1217766266 2000 dbSNP
rs1288840783 2001 dbSNP
rs1490008883 2018 dbSNP
rs974536157 2021 dbSNP
rs1268154475 2025 dbSNP
rs60599857 2029 dbSNP
rs1452301130 2039 dbSNP
rs186875727 2046 dbSNP
rs1180001310 2047 dbSNP
rs1363438883 2047 dbSNP
rs1023512538 2048 dbSNP
rs919572869 2050 dbSNP
rs1012078277 2055 dbSNP
rs972464462 2057 dbSNP
rs543935024 2058 dbSNP
rs576319889 2060 dbSNP
rs1034894969 2061 dbSNP
rs1389170189 2065 dbSNP
rs1465868505 2068 dbSNP
rs999216531 2085 dbSNP
rs902145629 2088 dbSNP
rs774018935 2089 dbSNP
rs563060970 2093 dbSNP
rs970216642 2094 dbSNP
rs1022974658 2098 dbSNP
rs1011601525 2099 dbSNP
rs1440575760 2106 dbSNP
rs900260177 2107 dbSNP
rs1346105964 2108 dbSNP
rs1031626214 2109 dbSNP
rs1303328743 2110 dbSNP
rs1443764038 2114 dbSNP
rs998876803 2118 dbSNP
rs1039884588 2121 dbSNP
rs1351515851 2123 dbSNP
rs1460068845 2124 dbSNP
rs1367970034 2125 dbSNP
rs778659371 2125 dbSNP
rs942840030 2127 dbSNP
rs1448540076 2130 dbSNP
rs912820767 2130 dbSNP
rs1334222949 2133 dbSNP
rs558137092 2140 dbSNP
rs1228104551 2142 dbSNP
rs1324009792 2150 dbSNP
rs1381687861 2152 dbSNP
rs766686673 2155 dbSNP
rs878870478 2156 dbSNP
rs546152688 2159 dbSNP
rs1008450019 2161 dbSNP
rs146630392 2162 dbSNP
rs1200817750 2165 dbSNP
rs918612823 2168 dbSNP
rs1394183335 2170 dbSNP
rs1049611619 2171 dbSNP
rs931047138 2173 dbSNP
rs554081826 2174 dbSNP
rs574492643 2175 dbSNP
rs779905433 2177 dbSNP
rs1451321655 2196 dbSNP
rs1037071293 2198 dbSNP
rs1023689604 2200 dbSNP
rs1466719675 2201 dbSNP
rs1173896081 2203 dbSNP
rs1371248449 2205 dbSNP
rs769766046 2213 dbSNP
rs960504684 2217 dbSNP
rs1191893842 2221 dbSNP
rs1381034465 2224 dbSNP
rs939703660 2225 dbSNP
rs1220509094 2226 dbSNP
rs1318773092 2226 dbSNP
rs1261553967 2233 dbSNP
rs1311849890 2237 dbSNP
rs1211034980 2238 dbSNP
rs1034954633 2241 dbSNP
rs1442450689 2255 dbSNP
rs1238991987 2259 dbSNP
rs1484738457 2259 dbSNP
rs928855332 2259 dbSNP
rs375948441 2262 dbSNP
rs1263809834 2264 dbSNP
rs1478539793 2273 dbSNP
rs1427935008 2276 dbSNP
rs966632827 2281 dbSNP
rs1208205778 2285 dbSNP
rs1022421065 2290 dbSNP
rs1010565479 2291 dbSNP
rs981728636 2292 dbSNP
rs970311482 2300 dbSNP
rs1280149295 2304 dbSNP
rs745655467 2319 dbSNP
rs541552078 2320 dbSNP
rs1038722907 2321 dbSNP
rs373233928 2323 dbSNP
rs1280984830 2326 dbSNP
rs1341083044 2326 dbSNP
rs957421026 2329 dbSNP
rs568364610 2336 dbSNP
rs999239031 2337 dbSNP
rs1413242758 2338 dbSNP
rs1197143748 2339 dbSNP
rs966085664 2346 dbSNP
rs1375062716 2350 dbSNP
rs758644300 2354 dbSNP
rs1405302011 2355 dbSNP
rs1431364837 2367 dbSNP
rs752878909 2370 dbSNP
rs1394283753 2372 dbSNP
rs555162193 2373 dbSNP
rs779079754 2374 dbSNP
rs765935220 2375 dbSNP
rs941303203 2376 dbSNP
rs916684813 2377 dbSNP
rs990871824 2378 dbSNP
rs960765375 2383 dbSNP
rs1422063408 2385 dbSNP
rs1369622560 2402 dbSNP
rs1185151753 2405 dbSNP
rs1349431240 2408 dbSNP
rs537152211 2408 dbSNP
rs560633866 2409 dbSNP
rs927809908 2409 dbSNP
rs1371428180 2410 dbSNP
rs1206356332 2411 dbSNP
rs1239639056 2411 dbSNP
rs1309757881 2411 dbSNP
rs1220183740 2418 dbSNP
rs898208470 2418 dbSNP
rs995346277 2418 dbSNP
rs977947325 2426 dbSNP
rs1036799104 2434 dbSNP
rs1223093934 2437 dbSNP
rs1271524445 2439 dbSNP
rs1230623977 2441 dbSNP
rs939651062 2441 dbSNP
rs1195665521 2443 dbSNP
rs369442149 2444 dbSNP
rs906853658 2448 dbSNP
rs1162296895 2449 dbSNP
rs1295263813 2451 dbSNP
rs1413665568 2459 dbSNP
rs1045829962 2464 dbSNP
rs1325639473 2467 dbSNP
rs1231509217 2470 dbSNP
rs1352802354 2470 dbSNP
rs1332232068 2471 dbSNP
rs1446331240 2471 dbSNP
rs574090098 2473 dbSNP
rs756026461 2474 dbSNP
rs1283572676 2476 dbSNP
rs967064715 2478 dbSNP
rs1289172745 2479 dbSNP
rs569519872 2485 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uuguuguuuagggucAGAUGGa 5'
                         |||||| 
Target 5' -------------acUCUACCa 3'
 		1 - 9
2 
miRNA  3' uuGUUGUUUAG-G---GUCAGAUGGA---- 5'
            | || |||| |   || |:||:||    
Target 5' cuCUACCAAUCACGGGCAUUUUAUCUUCUC 3'
 		2 - 31
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000273038.3 | 3UTR | ACUCUACCAAUCACGGGCAUUUUAUCUUCUCUGAACACUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
66 hsa-miR-3529-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT068541 NHLRC3 NHL repeat containing 3 2 6
MIRT094173 PCGF3 polycomb group ring finger 3 2 6
MIRT100107 ABT1 activator of basal transcription 1 2 8
MIRT120933 PDE12 phosphodiesterase 12 2 8
MIRT179060 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 6
MIRT202049 ZSWIM1 zinc finger SWIM-type containing 1 2 2
MIRT215733 C5ORF51 chromosome 5 open reading frame 51 2 10
MIRT254619 HIC2 HIC ZBTB transcriptional repressor 2 2 2
MIRT266230 PEX11B peroxisomal biogenesis factor 11 beta 2 2
MIRT297452 SLC20A1 solute carrier family 20 member 1 2 4
MIRT315453 SLC16A10 solute carrier family 16 member 10 2 2
MIRT442138 C3orf17 nucleolus and neural progenitor protein 2 2
MIRT453879 IFRD1 interferon related developmental regulator 1 2 12
MIRT456259 TDRKH tudor and KH domain containing 2 12
MIRT456413 MTRF1L mitochondrial translational release factor 1 like 2 2
MIRT459730 RRM1 ribonucleotide reductase catalytic subunit M1 2 2
MIRT461475 METTL1 methyltransferase like 1 2 2
MIRT463790 YBX1 Y-box binding protein 1 2 6
MIRT464032 WASL Wiskott-Aldrich syndrome like 2 2
MIRT464207 VGLL4 vestigial like family member 4 2 2
MIRT466713 SYNJ2BP synaptojanin 2 binding protein 2 2
MIRT467958 SLC16A1 solute carrier family 16 member 1 2 4
MIRT469225 RHOBTB3 Rho related BTB domain containing 3 2 2
MIRT473960 LRRC58 leucine rich repeat containing 58 2 2
MIRT475310 IFNLR1 interferon lambda receptor 1 2 2
MIRT476946 FAM83G family with sequence similarity 83 member G 2 4
MIRT477746 EDN1 endothelin 1 2 2
MIRT478261 DDX19B DEAD-box helicase 19B 2 2
MIRT478681 CSRP2 cysteine and glycine rich protein 2 2 4
MIRT490256 HAAO 3-hydroxyanthranilate 3,4-dioxygenase 2 2
MIRT493290 LNPEP leucyl and cystinyl aminopeptidase 2 2
MIRT493565 HSPA5 heat shock protein family A (Hsp70) member 5 2 2
MIRT495961 TBC1D19 TBC1 domain family member 19 2 2
MIRT497107 BEST3 bestrophin 3 2 2
MIRT498349 CISD1 CDGSH iron sulfur domain 1 2 2
MIRT500784 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 8
MIRT501092 SLC5A6 solute carrier family 5 member 6 2 4
MIRT505308 TPD52 tumor protein D52 2 2
MIRT511108 NFIB nuclear factor I B 2 4
MIRT512736 CD59 CD59 molecule (CD59 blood group) 2 4
MIRT514270 ZNF519 zinc finger protein 519 2 2
MIRT514603 NDUFA12 NADH:ubiquinone oxidoreductase subunit A12 2 4
MIRT515379 RPL7 ribosomal protein L7 2 2
MIRT518565 GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 2 2
MIRT520460 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT529766 SF3B1 splicing factor 3b subunit 1 2 2
MIRT538006 DNAL1 dynein axonemal light chain 1 2 2
MIRT538251 CUL3 cullin 3 2 4
MIRT543778 RBM12B RNA binding motif protein 12B 2 4
MIRT546204 TOR1AIP2 torsin 1A interacting protein 2 2 2
MIRT547202 PARP1 poly(ADP-ribose) polymerase 1 2 2
MIRT548441 ELMOD2 ELMO domain containing 2 2 2
MIRT551635 TRUB1 TruB pseudouridine synthase family member 1 2 4
MIRT553335 TSC22D2 TSC22 domain family member 2 2 2
MIRT556170 MCC mutated in colorectal cancers 2 2
MIRT557969 FAM222B family with sequence similarity 222 member B 2 2
MIRT560717 ZNF749 zinc finger protein 749 2 2
MIRT564115 ZYG11B zyg-11 family member B, cell cycle regulator 2 4
MIRT564375 MRPS18B mitochondrial ribosomal protein S18B 2 2
MIRT566934 LIN28B lin-28 homolog B 2 2
MIRT573339 TUBD1 tubulin delta 1 2 2
MIRT607187 SPRY4 sprouty RTK signaling antagonist 4 2 2
MIRT694902 THAP6 THAP domain containing 6 2 2
MIRT698514 TGFBR1 transforming growth factor beta receptor 1 2 2
MIRT704038 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT714583 PRRC1 proline rich coiled-coil 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3529-5p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-3529-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-3529-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-3529-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)

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