miRTarBase - #MIRT464278


—
pre-miRNA Information
pre-miRNA hsa-mir-4534   
Genomic Coordinates chr22: 37988794 - 37988853
Description Homo sapiens miR-4534 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4534
Sequence 36| GGAUGGAGGAGGGGUCU |52
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs890798116 2 dbSNP
rs1382774432 11 dbSNP
rs982883970 15 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol VASH1   
Synonyms KIAA1036
Description vasohibin 1
Transcript NM_014909   
Expression
Putative miRNA Targets on VASH1
3'UTR of VASH1
(miRNA target sites are highlighted)		 
>VASH1|NM_014909|3'UTR
   1 GGCGGATGCCAGCACCCCAGGCCCCACCCACTCTTGGGGGCCAGGATCCACCTGCTGGAACCAGCCTTATGCATGGGGAA
  81 GGCGGGGCTGGTGACAAGGCAGGGCAAGAGGCTGCAGGAAGAGTGTGTTCCAGCTCAGCCCCCCAAGCTGCTCTCGCTCC
 161 CACTGAGCCAAGCCCCCTAACTTTGGGCCTAGAGGCCGTTAGTATTTTATTTGGAGTTTTTAACTCTACAACTGAAGTTT
 241 AAGGTATTTGGGGAAAACTTAGTCCAAATGGATCTGCTGATGGTGGGAAGGCCAGTGCTTAACAAATCCATGTGTCATGG
 321 GGCCAGGTGAGGGAAACTGCTGGTTCTGCTGGTGCCTCTGCCCCTGGCTTCTCTCTGGGAGTTGGGTGCATCTTATCAGT
 401 GGGAAATCTCCCAGCCTTACCAGGCCTGTGATGGGGGGTGGGGGTGGGGTGGAGATGTTTCTCCAGTTCTGCCTGCCCTG
 481 GCAGAATCTTGACCCAGGGAAAGGGAAGCAGGGTAGGAGTCCTTCTGAGAAAGGTCTGTGTAGCCCATTAACCAGGAGCT
 561 TGGCACAGGCCACATCTGCCCCAAGAGCATGAGCTCGTGGCTCAGGAGAGCCTTCAGGCCCTTGAGGCCCCCATGGGCAG
 641 TGCTGTGTGGGCAGAGGAGGGGTGATATGAGAGCGAGCCCAGGGAAGGACCTCTGGGCAAAAAGTTCCCAGGCCCTAACT
 721 GCGTCTACTTGCTCAGTCCCAGCTCTGCCTGTTGCTCTAGCCCACAGGCTCCCTGCGGAGGGTCTGGGCTTGGCGGAGGA
 801 CCCAGAATGGCACTGAGGCCAGCATGGCTGTGGGAGTTGAGCAAACCCTGGGTGCCAGTCCAGGAGCTGTGGCTGGACAT
 881 GGGGTGATGGGGCGGGATGCTTGGGCCTGGGTCTCTCCGCCAGCAGTGCCAGGAGCCCTTGCTGGGGAAATCAAGACCAG
 961 ACTAGGATGCTTCTGCCCCAGGCCTGCCTTCCATTCTTTAACAGCCCATCTTGGCTTGGGGTTGCAATGATGGCTGGGCC
1041 AGTCACTTGTGGCAGGGCATCAGGGCCCTGGCAGGGAAGAACCTAGGCACCTGGGGTTGTCCCCAGCCTGCCCGTCAGCA
1121 TGAGATACCCAGTGGGAAAGTGAGAGGATGCGGAGAGGTTGGCAGAGCCAGGGGTAGGTTCTGGAGGCTCAAGCAACAAG
1201 GAGGTGCAGGTAAAGGGTGCAGTGCAGCCACTGAGGGACAGCTGGGAACTGGGGGATGCAAGTGAGAAAGGGATGTGGGG
1281 GAGAGTTCAGGATCAGGCTGCTTGAGGAGTAATGGGTTACCTACAGCAGAGACGAGATGGCTGTTTGTCAGGAGGCGGTA
1361 GAAAGGTAGAAAGGATTCAGATTGTGGAAGGGTAAACGGATGAGATGACCATTAAGGTTTTGTTTTACTGAGAGGCTGTA
1441 AGTCTGCCAGGGACAGCTGTCAGTAAGGCTGCAGAAGGGCTGGGGGGCTACACAAGGAAGAGCAGAACTAGGGTTGTAAG
1521 CTCAAATGACGAGCAAACGGTGAGAAGGAGGCCTGAAGGGCTGTGTGGGGACTATGGCTACCTGAAGAGGGCACACCCTG
1601 TTAAAGGGGCCACAGCTGCTCAGCTGTTCTTACAGTGCCGGCCCTGTGTTGCCAGATTGTCTGCTTTGTCAGAGGCCAGA
1681 ATTCTGACTTTTTATGTGAAATAGGATTTTTAAATGCTGGTGATCACTTAAAAAAAACTTAAAAACCCAATACTGGCAAA
1761 AGAGGATGCCAGTTTGCAATCCCTGAAGTAGAGAGAGCTCGTGCTGGGGAGAAGTCCACCAAGATGCTTTGAGGCGGGCT
1841 GTAGCAAAGTCCTGTTTCTCAGAGCTGGGCTGGGCTGGGGTAGGATCCTTGCAGCTGAGGAGGAGGAAAAGCCACTGAGT
1921 CTCCTCCCAGAGCGGGACAAACCAGAGGCCCTTTGCAGTTGCTGGGTCACCAGCGGGGGTGGCGCATGGAGTACAGACAG
2001 TGTAGCTCTTGGCCTGCCAGGGAGACGGATGGTGCCTTTGAAGCAAAGAGGAAGGGAAGGCAGAACCAGGGATGCCTTTG
2081 CTGATGAGAGTGCCTGTCAGGGAAGGCGCCACAGGCTGGCAGCTCTTCAAACCAGCAGCGCTTGACCCAGAGCCAGATCC
2161 AGCATGGCCTGGCCAGAGGCACCCTGGGAGGCCAGCTGGTCAGTCCCTTGCCTCCCCAAGTTCCCCCTGGGGTCAATGAG
2241 CCCTGGGAGGATGCCTAACCTAACTCCAGCCAGACTAATAGGGGCATGGTGACCCTTGACTCACCATCCCATCCCAGCTT
2321 TCAGGGAGTGGGGGTAGTGTGGTCTCCATGTTCCTACTATGCCTAAGAAGAGATGGCTCACCTTGGGAGGTGCCAGGCTG
2401 AAACTAGGTCCTTTCCGGGTCTGGATGCTGCCGCTCAGGAGCAGGGGCGTGGCCTCAGCTGCCTCTGGGAGCTTCCCGGG
2481 AATGACAGGGTTTGAGGGGAGTAGATATGAGAGGGAGCCGCTCCTGGTTCTGGAGTCTTAGGAGGTTCCAACTTGCAGGA
2561 TCCTTTCCCAGAGCCCTCCATGGAGAAAACAGCAAAATGAAGCCCTTACCTGCTTGCTGTCTGCAAGGGAGGGAGCCGAG
2641 CCCCAGCTGATAATCCCCCAGCACTCACCCTTCCTGAGCTGAGACTTCGGGGCTGTGGAGACCAGCACAGGACATAGTGG
2721 TGCTTTTTAAATTTATTTTTAACTGTTTCTCATATGTAGCAACCCCTCCTCCCCTCCTGGGCATGTTTACACAGGCTCTG
2801 CTCTGGGGGCTGGCCTGGCTGTGAGGTTTCTGGGGAGGCAGAGAGGCAGGGACTTTGGGGCCTTAGTCACCATCCATGGT
2881 ATCACCTCATCTCACTTCCTGTGAGGGACAGGGCCTGGCTGATGTGATCCCAGCTCCCCCCAGTTCAGGACTGTCTTTCA
2961 GCTCCTTTGCCCCTGGAGGTGGGGGCTGCTGGCTGAGGAGGGGTCAAGGTGAGTTCAAGAAAGCTACCTGTGGAAAATGG
3041 ACCAGGTTGGGGGGGTGATTGCAAAGTCTCCCCAAAGCCTGGCTCCTCATGCTCAGTGCCAGGGGCAGAACACTGGGGAG
3121 CCAGGTATAGAGAGCCTTCCTGTCATAACTGCCAGTCCTCTTCCTCCAAGGCCTCTGCATATTCTCATGTTCCCCTCACC
3201 CATCATGCCAGCCACCCCTATCCCTCTTCTAGCAGGGCCAAGATGGGGACAGCAGCAGCCCTCTGGCCTTGGGATGTGAT
3281 GATAAAGCAAGCCTAGGGCCAGGGTTTGGGGAGCAGAGAGAGCCAAGAAGTTGACCACGTGTGATTTCCAGCCCTTCCCA
3361 CTGGGACTTGACTTCCCAGGTCAAGGAGTCCGTCTCATTCTGGCTGGTCGAGTGACCAGAGGCCTGTGTGAATGTGTGCA
3441 CCTGCTTTTCCTGCCTGGAATGTTTTCTGGCTCAGCTGCAGCAACATCTGTGAGCCCAGTGTCTGCCCTGTGTCCCTGGG
3521 CTCGCTCCAAGTGCAGGAACATACATGCAGGGCCCAACATGATGATGGTGTGAAGGGCAGGAAACAGTCCTCTGAAGGAG
3601 TGGGGAGGTGGGCAGTCTGCCCCCGCCAGGTACCATCGCCTCCTGCCAGCTTCCTTAGACCAGGCAGGGCTGCCATGGTG
3681 CTAGCTGCAAGTCCATCAGTATTGACCGTCTCGCTCCATCTTGGTCCTCCGGAGTCCCAAGTTTCCTTTTCATCAAATCT
3761 GACAAGAGAGAAGAAACATGGGTGTGCTTGGCCCACAGGGCCTGGTGGTGATGGACCTCCCCGCTCCCTCAAGCTCTGGA
3841 TGGCTGCAGTGTTGTACTAGACTTTGTTCAGGCTGTTCTCATCTCAGTATTGCCCCTTCCTTTCACTTTCACACTTCATC
3921 TCATTCCTGTTGTCACTTTCCCCGAAACGAATAAAGTCTCCCCAGCTCCTGCTGTGTAGGCTGGGCAGAAACCACAACAC
4001 GT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucUGG-GGAG-GAGGUAGg 5'
            ||| :||| ||||||| 
Target 5' tgACCGTCTCGCTCCATCt 3'
 3703 - 3721 155.00 -21.30
2 
miRNA  3' ucugGGGAG---GAGGUAGg 5'
              |::||   ||:|||| 
Target 5' ttcaCTTTCACACTTCATCt 3'
 3902 - 3921 129.00 -10.70
3 
miRNA  3' ucuggggaGGAGGUAgg 5'
                  |||||||  
Target 5' cccagagcCCTCCATgg 3'
 2567 - 2583 125.00 -13.87
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM8597188 1 COSMIC
COSN30184581 4 COSMIC
COSN30497896 18 COSMIC
COSN31587475 32 COSMIC
COSN30477123 50 COSMIC
COSN30461411 79 COSMIC
COSN30505555 84 COSMIC
COSN31507807 97 COSMIC
COSN1171325 156 COSMIC
COSN31505828 157 COSMIC
COSN32073297 381 COSMIC
COSN1171326 411 COSMIC
COSN30571042 416 COSMIC
COSN32069856 427 COSMIC
COSN20521822 440 COSMIC
COSN32058683 605 COSMIC
COSN15312389 641 COSMIC
COSN19735783 649 COSMIC
COSN19694936 660 COSMIC
COSN22358758 797 COSMIC
COSN32090982 1508 COSMIC
COSN17217854 1652 COSMIC
COSN19335827 1738 COSMIC
COSN1659668 2330 COSMIC
COSN8387267 2622 COSMIC
COSN31593729 2866 COSMIC
COSN6542991 3284 COSMIC
COSN31594998 3639 COSMIC
COSN28746856 3708 COSMIC
COSN31521829 3718 COSMIC
COSN21516361 3760 COSMIC
COSN31536810 3768 COSMIC
COSN29678050 3788 COSMIC
COSN29888620 3861 COSMIC
COSN31556153 3882 COSMIC
COSN26573798 3924 COSMIC
COSN31591516 3973 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1341280123 2 dbSNP
rs751863547 4 dbSNP
rs779235767 4 dbSNP
rs765658659 5 dbSNP
rs755079577 20 dbSNP
rs1358082318 21 dbSNP
rs1356507683 22 dbSNP
rs1241449146 29 dbSNP
rs756835879 36 dbSNP
rs780783241 39 dbSNP
rs1201674561 41 dbSNP
rs1256485266 42 dbSNP
rs1456994682 44 dbSNP
rs769323232 48 dbSNP
rs1279018377 62 dbSNP
rs1016557685 66 dbSNP
rs1342755971 72 dbSNP
rs961002475 73 dbSNP
rs972635937 75 dbSNP
rs1207256579 78 dbSNP
rs143884436 84 dbSNP
rs1249398442 85 dbSNP
rs553797526 96 dbSNP
rs774809949 97 dbSNP
rs949945886 102 dbSNP
rs900971132 105 dbSNP
rs999349136 111 dbSNP
rs570685573 119 dbSNP
rs1451296075 124 dbSNP
rs979953878 125 dbSNP
rs1052729465 128 dbSNP
rs539645700 132 dbSNP
rs556389445 140 dbSNP
rs1452833987 142 dbSNP
rs1217410626 143 dbSNP
rs1193064471 144 dbSNP
rs1390911443 145 dbSNP
rs1430782207 147 dbSNP
rs576243359 151 dbSNP
rs1348752820 156 dbSNP
rs927087669 163 dbSNP
rs1451878516 173 dbSNP
rs1406682756 176 dbSNP
rs938114622 177 dbSNP
rs1023552472 179 dbSNP
rs1054256857 191 dbSNP
rs1476831705 195 dbSNP
rs1425655579 198 dbSNP
rs893825099 199 dbSNP
rs867044689 202 dbSNP
rs1477755879 227 dbSNP
rs1245000056 228 dbSNP
rs1224059942 233 dbSNP
rs1354484020 242 dbSNP
rs1452403391 249 dbSNP
rs969368620 250 dbSNP
rs1003555872 253 dbSNP
rs1320673494 259 dbSNP
rs774519128 259 dbSNP
rs1381889191 268 dbSNP
rs1440261127 271 dbSNP
rs1175333117 272 dbSNP
rs1375827822 274 dbSNP
rs962461152 275 dbSNP
rs17104866 284 dbSNP
rs1304601902 286 dbSNP
rs1407120137 292 dbSNP
rs555366905 296 dbSNP
rs768625500 301 dbSNP
rs774225820 304 dbSNP
rs762161590 307 dbSNP
rs781177281 311 dbSNP
rs901421596 311 dbSNP
rs1301269719 313 dbSNP
rs1463834428 321 dbSNP
rs758914383 322 dbSNP
rs1234795736 325 dbSNP
rs998794028 326 dbSNP
rs952271149 327 dbSNP
rs1028498749 328 dbSNP
rs1413776700 329 dbSNP
rs1423238060 335 dbSNP
rs1239592730 337 dbSNP
rs1458077112 339 dbSNP
rs1190404999 340 dbSNP
rs773464387 347 dbSNP
rs889912791 348 dbSNP
rs1434769055 350 dbSNP
rs1178364277 356 dbSNP
rs1237769274 357 dbSNP
rs111319945 363 dbSNP
rs986381674 365 dbSNP
rs1005316519 366 dbSNP
rs760709593 369 dbSNP
rs79823205 376 dbSNP
rs1259042102 377 dbSNP
rs754400669 380 dbSNP
rs759977366 382 dbSNP
rs540990467 383 dbSNP
rs1366123207 385 dbSNP
rs942355154 387 dbSNP
rs1041134418 388 dbSNP
rs1339339741 389 dbSNP
rs1348200061 396 dbSNP
rs1308114017 401 dbSNP
rs565759703 403 dbSNP
rs935112509 413 dbSNP
rs753018067 420 dbSNP
rs1298534232 427 dbSNP
rs1318149513 429 dbSNP
rs1220562756 430 dbSNP
rs1263413537 432 dbSNP
rs1489435588 433 dbSNP
rs749235394 434 dbSNP
rs1451826127 436 dbSNP
rs370722585 439 dbSNP
rs1052275480 440 dbSNP
rs533402528 440 dbSNP
rs1477573404 442 dbSNP
rs1191576652 443 dbSNP
rs1426060361 444 dbSNP
rs1410684498 445 dbSNP
rs1164558313 446 dbSNP
rs1348453541 448 dbSNP
rs1239241280 455 dbSNP
rs1181623828 456 dbSNP
rs893643681 458 dbSNP
rs961055881 463 dbSNP
rs1360445222 464 dbSNP
rs1397658797 473 dbSNP
rs1279476719 476 dbSNP
rs1010744637 478 dbSNP
rs1284607427 480 dbSNP
rs1237601918 484 dbSNP
rs1362262854 486 dbSNP
rs1227335890 487 dbSNP
rs1310106004 490 dbSNP
rs1323322868 494 dbSNP
rs1222020843 496 dbSNP
rs1307507806 498 dbSNP
rs1285289672 499 dbSNP
rs1487232487 500 dbSNP
rs1044975425 504 dbSNP
rs1376648115 507 dbSNP
rs1265383472 513 dbSNP
rs1475879166 514 dbSNP
rs972351881 516 dbSNP
rs1181550325 517 dbSNP
rs1415262787 518 dbSNP
rs1359985233 522 dbSNP
rs1411860560 523 dbSNP
rs1296414329 525 dbSNP
rs1421813359 529 dbSNP
rs1425997198 532 dbSNP
rs1364576814 534 dbSNP
rs1164593405 536 dbSNP
rs1360466400 537 dbSNP
rs1418366716 544 dbSNP
rs534454925 545 dbSNP
rs1345319054 546 dbSNP
rs1422465437 556 dbSNP
rs1446609331 560 dbSNP
rs1463022295 570 dbSNP
rs1300783061 571 dbSNP
rs1380867697 574 dbSNP
rs971348249 576 dbSNP
rs1246452151 577 dbSNP
rs868193328 581 dbSNP
rs980389878 588 dbSNP
rs927169630 592 dbSNP
rs1003526122 595 dbSNP
rs1172714189 597 dbSNP
rs751621373 598 dbSNP
rs1489091823 604 dbSNP
rs1260978627 607 dbSNP
rs1220311225 609 dbSNP
rs1447699113 611 dbSNP
rs1319720305 612 dbSNP
rs1209503978 618 dbSNP
rs1236005271 621 dbSNP
rs767611927 623 dbSNP
rs1339738415 624 dbSNP
rs1184597793 626 dbSNP
rs1380021620 627 dbSNP
rs1276439665 628 dbSNP
rs1401887204 630 dbSNP
rs1438196890 631 dbSNP
rs962144951 634 dbSNP
rs551335670 636 dbSNP
rs1409345817 638 dbSNP
rs1413465565 640 dbSNP
rs1173266268 641 dbSNP
rs1166090850 648 dbSNP
rs994027898 654 dbSNP
rs191926626 657 dbSNP
rs1196422497 659 dbSNP
rs1429799982 659 dbSNP
rs2280795 660 dbSNP
rs1241642682 663 dbSNP
rs986350694 666 dbSNP
rs566137848 668 dbSNP
rs527994228 669 dbSNP
rs528485845 671 dbSNP
rs183838228 675 dbSNP
rs934261042 676 dbSNP
rs1317261577 680 dbSNP
rs115083366 686 dbSNP
rs1220332499 695 dbSNP
rs1327114434 714 dbSNP
rs1300593028 719 dbSNP
rs889974445 720 dbSNP
rs1006120317 723 dbSNP
rs539734202 724 dbSNP
rs1327046236 728 dbSNP
rs1038108511 729 dbSNP
rs111968893 733 dbSNP
rs569843198 741 dbSNP
rs993845072 744 dbSNP
rs753785573 747 dbSNP
rs1156272722 748 dbSNP
rs1023928745 752 dbSNP
rs1344157887 756 dbSNP
rs971448113 758 dbSNP
rs1001475334 764 dbSNP
rs1034670071 767 dbSNP
rs915047359 770 dbSNP
rs748431831 775 dbSNP
rs1314582625 777 dbSNP
rs989981973 778 dbSNP
rs1457168787 783 dbSNP
rs535614651 796 dbSNP
rs966790979 798 dbSNP
rs1353485712 800 dbSNP
rs1413892634 813 dbSNP
rs939298083 819 dbSNP
rs12886600 823 dbSNP
rs1255538718 829 dbSNP
rs200519768 836 dbSNP
rs1288778146 838 dbSNP
rs1313990834 840 dbSNP
rs1304472331 849 dbSNP
rs1353091636 851 dbSNP
rs1222325501 854 dbSNP
rs1375155313 858 dbSNP
rs1283647846 859 dbSNP
rs1056465847 860 dbSNP
rs897823583 867 dbSNP
rs555182803 870 dbSNP
rs756951981 876 dbSNP
rs1396307858 879 dbSNP
rs1173887190 889 dbSNP
rs1438618851 891 dbSNP
rs1312909580 892 dbSNP
rs1378323426 894 dbSNP
rs879688605 895 dbSNP
rs1027751659 901 dbSNP
rs1255431437 902 dbSNP
rs1198616894 909 dbSNP
rs1255944288 910 dbSNP
rs74068853 911 dbSNP
rs1239782974 914 dbSNP
rs1050038475 915 dbSNP
rs1281689514 917 dbSNP
rs778782430 919 dbSNP
rs1007711963 920 dbSNP
rs1332797099 928 dbSNP
rs1398242663 930 dbSNP
rs1235000360 932 dbSNP
rs1017822254 934 dbSNP
rs911445081 948 dbSNP
rs941570742 949 dbSNP
rs1312950165 950 dbSNP
rs1418766326 966 dbSNP
rs1358202362 971 dbSNP
rs1159901114 972 dbSNP
rs1470404725 974 dbSNP
rs151219576 976 dbSNP
rs897291494 980 dbSNP
rs976743668 981 dbSNP
rs371522911 987 dbSNP
rs1258389952 988 dbSNP
rs1215955774 992 dbSNP
rs993897296 997 dbSNP
rs1286649355 1002 dbSNP
rs1045427935 1006 dbSNP
rs1205890454 1012 dbSNP
rs1029299052 1022 dbSNP
rs188283743 1024 dbSNP
rs1235745979 1029 dbSNP
rs956589527 1059 dbSNP
rs1175005962 1077 dbSNP
rs1373493824 1078 dbSNP
rs1293420640 1080 dbSNP
rs570727517 1081 dbSNP
rs1398885146 1084 dbSNP
rs906899399 1086 dbSNP
rs1001590942 1089 dbSNP
rs1319899411 1091 dbSNP
rs1400860139 1093 dbSNP
rs987886504 1096 dbSNP
rs1161230697 1097 dbSNP
rs1034311595 1103 dbSNP
rs1462996242 1104 dbSNP
rs914975336 1106 dbSNP
rs957509308 1114 dbSNP
rs1011464716 1115 dbSNP
rs1243859409 1122 dbSNP
rs1020130333 1126 dbSNP
rs1451243662 1127 dbSNP
rs1308380213 1132 dbSNP
rs967178321 1152 dbSNP
rs577959720 1153 dbSNP
rs1279128630 1156 dbSNP
rs1368580155 1160 dbSNP
rs143870199 1173 dbSNP
rs1278347682 1174 dbSNP
rs865803540 1175 dbSNP
rs1347752431 1178 dbSNP
rs939241198 1180 dbSNP
rs1056792310 1182 dbSNP
rs1206582710 1193 dbSNP
rs1323689925 1199 dbSNP
rs1442870891 1203 dbSNP
rs543693393 1204 dbSNP
rs922664965 1205 dbSNP
rs549945971 1206 dbSNP
rs1394883656 1220 dbSNP
rs374175802 1246 dbSNP
rs563568461 1247 dbSNP
rs897796993 1248 dbSNP
rs1463934631 1255 dbSNP
rs1275535531 1273 dbSNP
rs955424180 1278 dbSNP
rs1168552425 1281 dbSNP
rs1477849830 1284 dbSNP
rs573918829 1288 dbSNP
rs985862445 1290 dbSNP
rs911511024 1293 dbSNP
rs543165006 1301 dbSNP
rs1204269274 1304 dbSNP
rs775618234 1310 dbSNP
rs1469203662 1317 dbSNP
rs571546602 1317 dbSNP
rs941619924 1321 dbSNP
rs1049114017 1324 dbSNP
rs191820213 1332 dbSNP
rs528581584 1334 dbSNP
rs918768932 1335 dbSNP
rs930134446 1339 dbSNP
rs1300831363 1342 dbSNP
rs538021371 1343 dbSNP
rs997752635 1352 dbSNP
rs1032360243 1357 dbSNP
rs568330817 1357 dbSNP
rs1356180726 1358 dbSNP
rs1392770203 1360 dbSNP
rs1414001017 1373 dbSNP
rs956341742 1377 dbSNP
rs906946396 1383 dbSNP
rs1168485304 1390 dbSNP
rs2280796 1398 dbSNP
rs1407937854 1399 dbSNP
rs1327972855 1402 dbSNP
rs1481931305 1406 dbSNP
rs1055873808 1410 dbSNP
rs967766821 1411 dbSNP
rs1441347467 1412 dbSNP
rs776102160 1418 dbSNP
rs1011515647 1421 dbSNP
rs1443433918 1431 dbSNP
rs980488983 1434 dbSNP
rs1221825622 1436 dbSNP
rs926422901 1440 dbSNP
rs939194890 1444 dbSNP
rs1370415936 1449 dbSNP
rs1229246926 1459 dbSNP
rs1447117932 1465 dbSNP
rs1373786158 1469 dbSNP
rs992064898 1472 dbSNP
rs1272363171 1474 dbSNP
rs1435626853 1475 dbSNP
rs1360100125 1479 dbSNP
rs1421270914 1482 dbSNP
rs1020182545 1484 dbSNP
rs1195539899 1485 dbSNP
rs1254846951 1488 dbSNP
rs1291094672 1488 dbSNP
rs139353766 1494 dbSNP
rs1485815819 1500 dbSNP
rs1215254277 1502 dbSNP
rs1250587182 1503 dbSNP
rs1467594701 1513 dbSNP
rs903046869 1514 dbSNP
rs1284692351 1517 dbSNP
rs997331745 1522 dbSNP
rs1353461307 1529 dbSNP
rs919148791 1531 dbSNP
rs144085002 1532 dbSNP
rs1374686266 1536 dbSNP
rs1029785934 1537 dbSNP
rs146587334 1539 dbSNP
rs985524696 1540 dbSNP
rs1049089733 1543 dbSNP
rs761543300 1546 dbSNP
rs1420608157 1547 dbSNP
rs765458070 1550 dbSNP
rs773625874 1552 dbSNP
rs1475258142 1557 dbSNP
rs1018710375 1564 dbSNP
rs1260353621 1575 dbSNP
rs943399997 1580 dbSNP
rs1039151855 1584 dbSNP
rs1463196537 1585 dbSNP
rs1220522859 1588 dbSNP
rs1332361191 1590 dbSNP
rs183854781 1597 dbSNP
rs1275002401 1601 dbSNP
rs1233759453 1607 dbSNP
rs1394030400 1607 dbSNP
rs1317376602 1608 dbSNP
rs962657290 1612 dbSNP
rs1435849485 1613 dbSNP
rs998077354 1623 dbSNP
rs974325853 1634 dbSNP
rs1293349539 1635 dbSNP
rs569929484 1639 dbSNP
rs1320389815 1640 dbSNP
rs1325172536 1641 dbSNP
rs918823514 1641 dbSNP
rs763362945 1646 dbSNP
rs112172944 1656 dbSNP
rs766846263 1658 dbSNP
rs1337483061 1659 dbSNP
rs1429977413 1669 dbSNP
rs549116863 1670 dbSNP
rs1192564678 1673 dbSNP
rs149803277 1689 dbSNP
rs1254571507 1694 dbSNP
rs967693205 1695 dbSNP
rs1270810111 1696 dbSNP
rs1480258524 1697 dbSNP
rs565688033 1703 dbSNP
rs1001881336 1709 dbSNP
rs1263283965 1717 dbSNP
rs1033864232 1720 dbSNP
rs1232282965 1721 dbSNP
rs960510439 1730 dbSNP
rs937087529 1731 dbSNP
rs1446760045 1737 dbSNP
rs1394934815 1740 dbSNP
rs1055524581 1742 dbSNP
rs992387517 1751 dbSNP
rs892817728 1752 dbSNP
rs919138260 1756 dbSNP
rs534708535 1757 dbSNP
rs1396716927 1758 dbSNP
rs1417355695 1759 dbSNP
rs984714312 1769 dbSNP
rs1454544615 1777 dbSNP
rs557503083 1786 dbSNP
rs909184880 1790 dbSNP
rs943372057 1792 dbSNP
rs1382975382 1796 dbSNP
rs1041679751 1801 dbSNP
rs577196010 1802 dbSNP
rs372484447 1805 dbSNP
rs536623862 1809 dbSNP
rs1334303451 1810 dbSNP
rs535567015 1815 dbSNP
rs888932275 1816 dbSNP
rs1392410001 1819 dbSNP
rs113675356 1820 dbSNP
rs1432529042 1823 dbSNP
rs1376862474 1834 dbSNP
rs759568533 1836 dbSNP
rs1001806331 1837 dbSNP
rs1354406394 1843 dbSNP
rs1239370276 1850 dbSNP
rs1256963533 1852 dbSNP
rs962711013 1853 dbSNP
rs1261958127 1854 dbSNP
rs974043524 1858 dbSNP
rs960728630 1860 dbSNP
rs1025888291 1861 dbSNP
rs1280903319 1864 dbSNP
rs1486622701 1868 dbSNP
rs951640494 1870 dbSNP
rs1185497160 1875 dbSNP
rs981676250 1882 dbSNP
rs1026533974 1897 dbSNP
rs1419895275 1901 dbSNP
rs1184326710 1903 dbSNP
rs1313126185 1904 dbSNP
rs542897989 1907 dbSNP
rs1160065827 1911 dbSNP
rs928812788 1916 dbSNP
rs950544645 1918 dbSNP
rs1185654515 1932 dbSNP
rs937494662 1934 dbSNP
rs767656807 1935 dbSNP
rs1192826478 1938 dbSNP
rs376797705 1956 dbSNP
rs1445478929 1971 dbSNP
rs914306060 1973 dbSNP
rs947075456 1975 dbSNP
rs559887851 1976 dbSNP
rs761034650 1978 dbSNP
rs1377748726 1980 dbSNP
rs924238575 1984 dbSNP
rs1284263686 1995 dbSNP
rs533551593 1999 dbSNP
rs1429653640 2004 dbSNP
rs1324289841 2008 dbSNP
rs1051659349 2019 dbSNP
rs888976671 2027 dbSNP
rs975143109 2028 dbSNP
rs35776488 2029 dbSNP
rs1393514863 2039 dbSNP
rs545459390 2040 dbSNP
rs1462947694 2044 dbSNP
rs1007375537 2055 dbSNP
rs1039805012 2056 dbSNP
rs1167382677 2073 dbSNP
rs1333650499 2074 dbSNP
rs898579746 2077 dbSNP
rs1491215303 2086 dbSNP
rs777334086 2087 dbSNP
rs1303565623 2090 dbSNP
rs1349922044 2092 dbSNP
rs1216168019 2093 dbSNP
rs186728290 2096 dbSNP
rs913358943 2100 dbSNP
rs1213512508 2101 dbSNP
rs1025605062 2103 dbSNP
rs951387717 2108 dbSNP
rs1003548247 2109 dbSNP
rs906111035 2110 dbSNP
rs1323626001 2112 dbSNP
rs1035930149 2136 dbSNP
rs937627944 2140 dbSNP
rs1055159923 2141 dbSNP
rs959149340 2147 dbSNP
rs991669524 2151 dbSNP
rs914358369 2155 dbSNP
rs968462348 2157 dbSNP
rs1421668222 2158 dbSNP
rs896162011 2159 dbSNP
rs1453988864 2166 dbSNP
rs1013723907 2167 dbSNP
rs530942255 2169 dbSNP
rs1026082209 2179 dbSNP
rs886215557 2190 dbSNP
rs80016145 2191 dbSNP
rs1202970819 2192 dbSNP
rs1435578843 2194 dbSNP
rs77515847 2211 dbSNP
rs1248643900 2218 dbSNP
rs563579526 2218 dbSNP
rs368125426 2220 dbSNP
rs1016141324 2221 dbSNP
rs548949398 2222 dbSNP
rs974689119 2223 dbSNP
rs1356419556 2227 dbSNP
rs1381589055 2232 dbSNP
rs1308698200 2237 dbSNP
rs1434382820 2238 dbSNP
rs1052139163 2243 dbSNP
rs572303519 2248 dbSNP
rs1373907600 2251 dbSNP
rs910468262 2254 dbSNP
rs943234122 2261 dbSNP
rs1037506766 2265 dbSNP
rs954744032 2274 dbSNP
rs989275538 2280 dbSNP
rs1471435792 2281 dbSNP
rs1234158325 2282 dbSNP
rs913300689 2285 dbSNP
rs145709655 2293 dbSNP
rs995565852 2295 dbSNP
rs534448577 2297 dbSNP
rs1463813833 2299 dbSNP
rs1212503022 2304 dbSNP
rs551084434 2306 dbSNP
rs1002855106 2309 dbSNP
rs1375403253 2330 dbSNP
rs1288867572 2331 dbSNP
rs1414269562 2335 dbSNP
rs1353580731 2347 dbSNP
rs1036393231 2350 dbSNP
rs1466745479 2351 dbSNP
rs1345032607 2356 dbSNP
rs1325985668 2357 dbSNP
rs937557149 2359 dbSNP
rs1413381194 2365 dbSNP
rs958978998 2365 dbSNP
rs570976183 2371 dbSNP
rs1231462902 2373 dbSNP
rs558553187 2383 dbSNP
rs896116713 2389 dbSNP
rs191098698 2397 dbSNP
rs1483364514 2400 dbSNP
rs1241353689 2407 dbSNP
rs1213424442 2408 dbSNP
rs1047882511 2417 dbSNP
rs534099870 2418 dbSNP
rs1268708114 2422 dbSNP
rs536935751 2433 dbSNP
rs977198549 2434 dbSNP
rs1361496011 2444 dbSNP
rs1287289834 2446 dbSNP
rs924366684 2447 dbSNP
rs954567502 2449 dbSNP
rs184314712 2450 dbSNP
rs1016064047 2462 dbSNP
rs1325828312 2467 dbSNP
rs573403811 2473 dbSNP
rs900343903 2478 dbSNP
rs910178100 2479 dbSNP
rs1255139242 2482 dbSNP
rs148917645 2484 dbSNP
rs1423850811 2485 dbSNP
rs1193119236 2488 dbSNP
rs973272368 2502 dbSNP
rs1248408847 2507 dbSNP
rs1467070772 2514 dbSNP
rs920439806 2514 dbSNP
rs929126721 2520 dbSNP
rs371458426 2521 dbSNP
rs1306936538 2527 dbSNP
rs1293716722 2534 dbSNP
rs1216476773 2544 dbSNP
rs1366458257 2546 dbSNP
rs1303109856 2547 dbSNP
rs1397285152 2549 dbSNP
rs1168735471 2550 dbSNP
rs575764442 2552 dbSNP
rs1464763336 2560 dbSNP
rs1353348977 2572 dbSNP
rs1326100129 2580 dbSNP
rs938714759 2586 dbSNP
rs954811234 2586 dbSNP
rs1057139268 2592 dbSNP
rs1452302339 2593 dbSNP
rs544666956 2597 dbSNP
rs968770225 2603 dbSNP
rs894425927 2606 dbSNP
rs1249682709 2620 dbSNP
rs777923042 2630 dbSNP
rs1343110848 2635 dbSNP
rs1013191764 2636 dbSNP
rs750221702 2638 dbSNP
rs904717670 2639 dbSNP
rs958921688 2645 dbSNP
rs1372058865 2653 dbSNP
rs1295927573 2655 dbSNP
rs999021109 2657 dbSNP
rs375874854 2660 dbSNP
rs529210745 2670 dbSNP
rs11558546 2671 dbSNP
rs1172573804 2675 dbSNP
rs930257491 2682 dbSNP
rs542885554 2689 dbSNP
rs1017291250 2690 dbSNP
rs964316777 2692 dbSNP
rs941724952 2698 dbSNP
rs1418416579 2701 dbSNP
rs1248569200 2712 dbSNP
rs1037466628 2716 dbSNP
rs900311248 2729 dbSNP
rs1208918134 2736 dbSNP
rs1347665824 2740 dbSNP
rs1256943160 2741 dbSNP
rs1239024971 2744 dbSNP
rs973321491 2747 dbSNP
rs920491692 2753 dbSNP
rs1309743006 2756 dbSNP
rs1411153574 2764 dbSNP
rs1275238803 2770 dbSNP
rs1311896791 2772 dbSNP
rs929178828 2775 dbSNP
rs143845202 2777 dbSNP
rs927752758 2785 dbSNP
rs1172922470 2786 dbSNP
rs1242815081 2789 dbSNP
rs1487132170 2795 dbSNP
rs1453016639 2796 dbSNP
rs1010607631 2799 dbSNP
rs1020201640 2804 dbSNP
rs968704663 2807 dbSNP
rs1000214828 2808 dbSNP
rs1444324172 2827 dbSNP
rs1257352559 2828 dbSNP
rs1204953172 2832 dbSNP
rs1348929961 2834 dbSNP
rs1270587129 2835 dbSNP
rs753413260 2836 dbSNP
rs938781045 2841 dbSNP
rs1292114819 2842 dbSNP
rs1475703927 2844 dbSNP
rs1341858613 2850 dbSNP
rs1167593500 2851 dbSNP
rs1334356957 2856 dbSNP
rs576850718 2857 dbSNP
rs993005579 2859 dbSNP
rs1459592536 2866 dbSNP
rs537957735 2868 dbSNP
rs572416154 2868 dbSNP
rs1163426443 2880 dbSNP
rs1473796777 2880 dbSNP
rs1345338561 2887 dbSNP
rs1192676696 2896 dbSNP
rs951625183 2902 dbSNP
rs1250280197 2909 dbSNP
rs948683346 2918 dbSNP
rs1209963139 2934 dbSNP
rs907507023 2936 dbSNP
rs1272033203 2937 dbSNP
rs1043368287 2941 dbSNP
rs148161708 2944 dbSNP
rs1284430102 2945 dbSNP
rs1226234835 2950 dbSNP
rs1339795174 2955 dbSNP
rs1415115136 2958 dbSNP
rs999076510 2967 dbSNP
rs1031844700 2971 dbSNP
rs1353759515 2976 dbSNP
rs921688602 2983 dbSNP
rs530510932 2986 dbSNP
rs1435778169 2992 dbSNP
rs1393687024 2998 dbSNP
rs890597825 3002 dbSNP
rs931757797 3009 dbSNP
rs550194838 3018 dbSNP
rs1407171265 3023 dbSNP
rs1391450752 3031 dbSNP
rs567231362 3046 dbSNP
rs1051601230 3049 dbSNP
rs1167622710 3049 dbSNP
rs1008662484 3050 dbSNP
rs758308332 3051 dbSNP
rs1251706200 3052 dbSNP
rs1213745283 3054 dbSNP
rs1452900313 3055 dbSNP
rs1285884088 3060 dbSNP
rs1194923842 3068 dbSNP
rs1041636637 3069 dbSNP
rs1276287850 3080 dbSNP
rs1228900373 3081 dbSNP
rs1369904094 3084 dbSNP
rs535842544 3087 dbSNP
rs1190491411 3090 dbSNP
rs553641530 3095 dbSNP
rs1331807297 3100 dbSNP
rs964368775 3105 dbSNP
rs1372673957 3106 dbSNP
rs1169410896 3107 dbSNP
rs17104869 3119 dbSNP
rs1393653544 3120 dbSNP
rs539235973 3129 dbSNP
rs1034348891 3141 dbSNP
rs1478631510 3147 dbSNP
rs78642259 3149 dbSNP
rs746967382 3155 dbSNP
rs1246827722 3159 dbSNP
rs1180511399 3165 dbSNP
rs894559680 3172 dbSNP
rs1180985620 3177 dbSNP
rs1205350749 3178 dbSNP
rs1346960768 3179 dbSNP
rs1014758595 3180 dbSNP
rs34354295 3192 dbSNP
rs950643982 3194 dbSNP
rs1220920893 3198 dbSNP
rs1345588247 3201 dbSNP
rs1278840140 3211 dbSNP
rs1408101313 3212 dbSNP
rs1408286904 3215 dbSNP
rs1024445159 3219 dbSNP
rs1308870394 3219 dbSNP
rs983734224 3221 dbSNP
rs951642834 3223 dbSNP
rs1415364700 3225 dbSNP
rs1407925763 3229 dbSNP
rs983006744 3238 dbSNP
rs1359800458 3241 dbSNP
rs1435305888 3246 dbSNP
rs1253343991 3255 dbSNP
rs1182519883 3259 dbSNP
rs1485125810 3277 dbSNP
rs1235560335 3279 dbSNP
rs1212010144 3282 dbSNP
rs1314481079 3286 dbSNP
rs1442737341 3289 dbSNP
rs1283492381 3302 dbSNP
rs927836888 3304 dbSNP
rs1331383879 3305 dbSNP
rs1289044246 3307 dbSNP
rs1232943173 3315 dbSNP
rs1377287100 3317 dbSNP
rs1304760851 3319 dbSNP
rs190825953 3322 dbSNP
rs1449234626 3329 dbSNP
rs1319219563 3331 dbSNP
rs767995467 3334 dbSNP
rs575850464 3336 dbSNP
rs115290387 3342 dbSNP
rs193060708 3353 dbSNP
rs574798397 3357 dbSNP
rs540231239 3358 dbSNP
rs1411207813 3377 dbSNP
rs1280295538 3380 dbSNP
rs185430481 3392 dbSNP
rs987634755 3393 dbSNP
rs528370995 3399 dbSNP
rs934921266 3408 dbSNP
rs1258939151 3410 dbSNP
rs1268644804 3419 dbSNP
rs544843359 3426 dbSNP
rs1349194647 3427 dbSNP
rs189860248 3442 dbSNP
rs1319945500 3467 dbSNP
rs530548089 3480 dbSNP
rs769478536 3487 dbSNP
rs1315119052 3488 dbSNP
rs1213728189 3501 dbSNP
rs1361775171 3506 dbSNP
rs550280457 3507 dbSNP
rs1295824338 3518 dbSNP
rs1437948107 3523 dbSNP
rs1278618032 3524 dbSNP
rs1390057590 3527 dbSNP
rs1325765569 3529 dbSNP
rs1456982502 3531 dbSNP
rs1347544894 3537 dbSNP
rs117459334 3541 dbSNP
rs867867533 3542 dbSNP
rs1038818874 3549 dbSNP
rs1233046648 3561 dbSNP
rs1262437874 3564 dbSNP
rs904441444 3568 dbSNP
rs1444253809 3577 dbSNP
rs900250555 3590 dbSNP
rs1248581300 3597 dbSNP
rs1190480455 3603 dbSNP
rs1470986473 3607 dbSNP
rs994512387 3619 dbSNP
rs1055760849 3620 dbSNP
rs1379222943 3624 dbSNP
rs529700465 3625 dbSNP
rs950362043 3626 dbSNP
rs1231105889 3636 dbSNP
rs1014309599 3639 dbSNP
rs1004815109 3640 dbSNP
rs1175371032 3646 dbSNP
rs1035330877 3648 dbSNP
rs1393195441 3649 dbSNP
rs1385590920 3651 dbSNP
rs1364948726 3656 dbSNP
rs1294742332 3661 dbSNP
rs1457933328 3662 dbSNP
rs960612725 3668 dbSNP
rs991053488 3670 dbSNP
rs1413663484 3676 dbSNP
rs1431400992 3684 dbSNP
rs916384953 3687 dbSNP
rs970134292 3688 dbSNP
rs1329322339 3689 dbSNP
rs546229758 3693 dbSNP
rs544444650 3694 dbSNP
rs887212110 3699 dbSNP
rs1004368430 3704 dbSNP
rs1440348529 3706 dbSNP
rs181353820 3708 dbSNP
rs1249910658 3709 dbSNP
rs1371892093 3713 dbSNP
rs185528906 3714 dbSNP
rs1053394372 3717 dbSNP
rs61992273 3724 dbSNP
rs975663471 3731 dbSNP
rs552841940 3732 dbSNP
rs1344950562 3739 dbSNP
rs1386855580 3748 dbSNP
rs1349261488 3749 dbSNP
rs1305868082 3751 dbSNP
rs1411259205 3757 dbSNP
rs1028623139 3764 dbSNP
rs1302018083 3764 dbSNP
rs1464324169 3766 dbSNP
rs1379325409 3769 dbSNP
rs569453998 3773 dbSNP
rs1472308973 3775 dbSNP
rs1409845656 3778 dbSNP
rs1182045826 3789 dbSNP
rs1483491979 3798 dbSNP
rs538414096 3801 dbSNP
rs1255685323 3804 dbSNP
rs200353308 3806 dbSNP
rs555068809 3808 dbSNP
rs386778990 3809 dbSNP
rs944925114 3809 dbSNP
rs999624514 3809 dbSNP
rs370631142 3810 dbSNP
rs1484407961 3811 dbSNP
rs565183050 3812 dbSNP
rs1468482615 3813 dbSNP
rs1194992598 3814 dbSNP
rs911618409 3816 dbSNP
rs866622390 3821 dbSNP
rs562665130 3823 dbSNP
rs900638285 3824 dbSNP
rs1350765316 3826 dbSNP
rs994563291 3835 dbSNP
rs542103279 3847 dbSNP
rs1333043715 3861 dbSNP
rs935888535 3898 dbSNP
rs1048769869 3907 dbSNP
rs1168254313 3907 dbSNP
rs1421477311 3913 dbSNP
rs1386609050 3924 dbSNP
rs1161423330 3942 dbSNP
rs1472930505 3943 dbSNP
rs1368127876 3944 dbSNP
rs886134498 3945 dbSNP
rs1170169665 3946 dbSNP
rs1056132507 3949 dbSNP
rs1004952886 3950 dbSNP
rs1034977601 3954 dbSNP
rs896402208 3964 dbSNP
rs1443129046 3971 dbSNP
rs950074537 3980 dbSNP
rs774790329 3986 dbSNP
rs1012127101 3996 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ucuGGGGAGGAGGuagg 5'
             ||||||||||    
Target 5' ---CCCCUCCUCCccuc 3'
 		1 - 14
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000167106.4 | 3UTR | CCCCUCCUCCCCUCCUGGGCAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
141 hsa-miR-4534 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT087131 CRKL CRK like proto-oncogene, adaptor protein 2 2
MIRT179641 CAPZA1 capping actin protein of muscle Z-line alpha subunit 1 2 2
MIRT243304 SLC25A36 solute carrier family 25 member 36 2 2
MIRT325574 HIATL1 major facilitator superfamily domain containing 14B 2 4
MIRT448776 GNA13 G protein subunit alpha 13 2 2
MIRT451456 HSD11B1L hydroxysteroid 11-beta dehydrogenase 1 like 2 2
MIRT452150 PPP2R1B protein phosphatase 2 scaffold subunit Abeta 2 2
MIRT454199 HLA-A major histocompatibility complex, class I, A 2 2
MIRT455984 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT456058 SLC25A28 solute carrier family 25 member 28 2 2
MIRT457082 XPNPEP3 X-prolyl aminopeptidase 3 2 2
MIRT457278 ALDH9A1 aldehyde dehydrogenase 9 family member A1 2 2
MIRT457361 POFUT2 protein O-fucosyltransferase 2 2 2
MIRT457396 CAMK2A calcium/calmodulin dependent protein kinase II alpha 2 2
MIRT458817 ZNF843 zinc finger protein 843 2 2
MIRT459697 VPS37C VPS37C, ESCRT-I subunit 2 2
MIRT460346 ARL14EP ADP ribosylation factor like GTPase 14 effector protein 2 2
MIRT462713 MAPK13 mitogen-activated protein kinase 13 2 2
MIRT464278 VASH1 vasohibin 1 2 2
MIRT465634 TNRC18P2 trinucleotide repeat containing 18 pseudogene 2 2 10
MIRT465772 TMOD3 tropomodulin 3 2 2
MIRT466414 TFDP1 transcription factor Dp-1 2 2
MIRT467122 SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 2 8
MIRT467475 SMYD1 SET and MYND domain containing 1 2 4
MIRT468462 SET SET nuclear proto-oncogene 2 2
MIRT468618 SUMO1 small ubiquitin-like modifier 1 2 2
MIRT468835 RRM2 ribonucleotide reductase regulatory subunit M2 2 4
MIRT470890 PLXND1 plexin D1 2 2
MIRT473226 SMCR7L mitochondrial elongation factor 1 2 4
MIRT473858 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT474975 KCND3 potassium voltage-gated channel subfamily D member 3 2 2
MIRT475858 H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase 2 2
MIRT478569 CTNND1 catenin delta 1 2 2
MIRT479347 CEP97 centrosomal protein 97 2 2
MIRT479910 CCDC117 coiled-coil domain containing 117 2 4
MIRT480122 CALR calreticulin 2 2
MIRT480892 BCL9L B-cell CLL/lymphoma 9 like 2 2
MIRT481149 AVL9 AVL9 cell migration associated 2 6
MIRT481527 ARL5B ADP ribosylation factor like GTPase 5B 2 10
MIRT481896 ANKRD40 ankyrin repeat domain 40 2 2
MIRT490138 FN3K fructosamine 3 kinase 2 4
MIRT490329 ANK1 ankyrin 1 2 4
MIRT491472 TMEM214 transmembrane protein 214 2 2
MIRT503552 TIGIT T-cell immunoreceptor with Ig and ITIM domains 2 4
MIRT504413 TUBA1B tubulin alpha 1b 2 4
MIRT508207 SLC35E1 solute carrier family 35 member E1 2 2
MIRT508333 SLC37A4 solute carrier family 37 member 4 2 6
MIRT516381 TRAF3IP2 TRAF3 interacting protein 2 2 4
MIRT518549 ABCA6 ATP binding cassette subfamily A member 6 2 2
MIRT522545 MED28 mediator complex subunit 28 2 6
MIRT522592 MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1 like 2 2
MIRT522923 KAT6A lysine acetyltransferase 6A 2 4
MIRT525937 C11orf74 chromosome 11 open reading frame 74 2 2
MIRT527021 PABPN1L poly(A) binding protein nuclear 1 like, cytoplasmic 2 2
MIRT530396 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT530660 TRIM56 tripartite motif containing 56 2 2
MIRT531625 TM4SF5 transmembrane 4 L six family member 5 2 4
MIRT532703 TCN2 transcobalamin 2 2 4
MIRT540173 MB21D1 Mab-21 domain containing 1 2 2
MIRT540756 UTP6 UTP6, small subunit processome component 2 2
MIRT541966 ZNF485 zinc finger protein 485 2 2
MIRT542738 RAF1 Raf-1 proto-oncogene, serine/threonine kinase 2 2
MIRT543090 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT550687 YARS tyrosyl-tRNA synthetase 2 2
MIRT553466 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT559980 RELA RELA proto-oncogene, NF-kB subunit 2 2
MIRT561084 LLPH LLP homolog, long-term synaptic facilitation 2 2
MIRT561738 PLAGL2 PLAG1 like zinc finger 2 2 2
MIRT569872 KLK10 kallikrein related peptidase 10 2 2
MIRT570264 ARPC3 actin related protein 2/3 complex subunit 3 2 2
MIRT573431 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT573874 PRPS1L1 phosphoribosyl pyrophosphate synthetase 1-like 1 2 2
MIRT576905 Poteg POTE ankyrin domain family, member G 2 2
MIRT607934 ANG angiogenin 2 2
MIRT609472 RPL7L1 ribosomal protein L7 like 1 2 4
MIRT612179 EMC3 ER membrane protein complex subunit 3 2 2
MIRT613428 GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 2 2
MIRT613746 GPR155 G protein-coupled receptor 155 2 2
MIRT615034 DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 2
MIRT615565 JPH2 junctophilin 2 2 2
MIRT615937 MAP1LC3B microtubule associated protein 1 light chain 3 beta 2 2
MIRT616643 LRAT lecithin retinol acyltransferase 2 4
MIRT630890 SLC25A33 solute carrier family 25 member 33 2 2
MIRT636542 FAM126B family with sequence similarity 126 member B 2 2
MIRT641392 NUBPL nucleotide binding protein like 2 2
MIRT641410 SCN2B sodium voltage-gated channel beta subunit 2 2 2
MIRT643184 HYPK huntingtin interacting protein K 2 2
MIRT652600 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT653974 SEMA7A semaphorin 7A (John Milton Hagen blood group) 2 2
MIRT655692 NUDT3 nudix hydrolase 3 2 2
MIRT660734 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 4
MIRT661604 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT663284 ZNF675 zinc finger protein 675 2 2
MIRT666337 SKAP2 src kinase associated phosphoprotein 2 2 2
MIRT666636 RBMS2 RNA binding motif single stranded interacting protein 2 2 2
MIRT667125 OCIAD2 OCIA domain containing 2 2 2
MIRT670412 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT671119 ZNF573 zinc finger protein 573 2 2
MIRT671152 ANKRD9 ankyrin repeat domain 9 2 2
MIRT671336 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT671867 ZNF429 zinc finger protein 429 2 2
MIRT671972 IKZF3 IKAROS family zinc finger 3 2 2
MIRT672062 KIAA0930 KIAA0930 2 2
MIRT672652 SLC25A16 solute carrier family 25 member 16 2 4
MIRT672671 GTF2H5 general transcription factor IIH subunit 5 2 2
MIRT672768 UBE2V2 ubiquitin conjugating enzyme E2 V2 2 2
MIRT672927 LRRC2 leucine rich repeat containing 2 2 2
MIRT673156 C1orf50 chromosome 1 open reading frame 50 2 2
MIRT673270 RUNDC1 RUN domain containing 1 2 2
MIRT673329 THAP1 THAP domain containing 1 2 2
MIRT673348 SLC35F6 solute carrier family 35 member F6 2 2
MIRT673664 ZNF440 zinc finger protein 440 2 2
MIRT673901 DCTN6 dynactin subunit 6 2 2
MIRT674399 MYCBP MYC binding protein 2 2
MIRT674523 PRR23A proline rich 23A 2 2
MIRT674831 ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 2 2
MIRT675064 FGD6 FYVE, RhoGEF and PH domain containing 6 2 2
MIRT675078 CCR6 C-C motif chemokine receptor 6 2 2
MIRT675123 FSD2 fibronectin type III and SPRY domain containing 2 2 2
MIRT679399 IL10RB interleukin 10 receptor subunit beta 2 2
MIRT686608 TMEM70 transmembrane protein 70 2 2
MIRT690371 ZSWIM7 zinc finger SWIM-type containing 7 2 2
MIRT694464 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT695706 OLA1 Obg like ATPase 1 2 2
MIRT696846 WDR13 WD repeat domain 13 2 2
MIRT700894 PER2 period circadian clock 2 2 2
MIRT701924 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT704918 CCDC36 coiled-coil domain containing 36 2 2
MIRT706211 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT706546 GJD2 gap junction protein delta 2 2 2
MIRT706727 RFK riboflavin kinase 2 2
MIRT707366 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT707416 RRP7A ribosomal RNA processing 7 homolog A 2 2
MIRT710646 GLUL glutamate-ammonia ligase 2 2
MIRT712298 PGM2L1 phosphoglucomutase 2 like 1 2 2
MIRT713709 HIST3H2BB histone cluster 3 H2B family member b 2 2
MIRT713751 SLC9A8 solute carrier family 9 member A8 2 2
MIRT716423 VPS53 VPS53, GARP complex subunit 2 2
MIRT717169 UCHL3 ubiquitin C-terminal hydrolase L3 2 2
MIRT718877 PDIA3 protein disulfide isomerase family A member 3 2 2
MIRT720096 SPTLC3 serine palmitoyltransferase long chain base subunit 3 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4534 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4534 Fluorouracil 3385 NSC19893 approved sensitive High Pancreatic Cancer cell line (PATU8988)
hsa-miR-4534 Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4534 Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4534 Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4534 Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-mir-4534 Androstenedione+Anastrozole sensitive cell line (MCF-7)
hsa-mir-4534 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4534 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (cytosolic RNA)
hsa-miR-4534 Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-4534 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4534 Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4534 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4534 Platinum 23939 resistant tissue
hsa-miR-4534 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4534 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4534 Cisplatin 5460033 NSC119875 approved resistant cell line (A549)

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