miRTarBase - #MIRT464366


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pre-miRNA Information
pre-miRNA hsa-mir-3180-1   
Genomic Coordinates chr16: 14911220 - 14911313
Description Homo sapiens miR-3180-1 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-3180-2   
Genomic Coordinates chr16: 16309879 - 16309966
Description Homo sapiens miR-3180-2 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-3180-3   
Genomic Coordinates chr16: 18402178 - 18402271
Description Homo sapiens miR-3180-3 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3180-5p
Sequence 18| CUUCCAGACGCUCCGCCCCACGUCG |42
Evidence Experimental
Experiments Illumina
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol URM1   
Synonyms C9orf74
Description ubiquitin related modifier 1
Transcript NM_001135947   
Other Transcripts NM_030914   
Expression
Putative miRNA Targets on URM1
3'UTR of URM1
(miRNA target sites are highlighted)		 
>URM1|NM_001135947|3'UTR
   1 AGATTTGCAGGTTGAGGTATAGGATACCCATTTTTCTGGTAGAGTCTGTCTCTTCCAGAGCAGCCAGTCCTCAGCCCCTG
  81 TTCTCCCAACTCCTGGGGTGGACCTGGGAAGGTGGCCCTGAGGGTCTCCCGCTCCCCTCTCTCCCGCACCAGGGTGAGCT
 161 GGACTACCAGCTTCAGGACCAGGACAGCGTCCTCTTCATCTCCACTCTGCACGGCGGCTGAGGGCCCTTCTCTGGGCCTG
 241 GGCACCCTTAGAGGGGAGAACGAAGCAATCAGACATCCCCTTGGGCCCTGCTTCCAGGTCTCCCTGTCCCCCTTGCCTGC
 321 CTTCTTCCCTGCTCTGTCCCCTAAGCTCCCTCCAGGCAGGGAAAAGAGGCCAGGTGCTAAAAATGAGCCTTTCTCAAGCA
 401 CGTGAGCAGCGGAAGGCAGACAGGCGCCAGAGCCCAGCACTCCCTTTTCCAGCAGCTGTGGTGGGGGAGGGTTCCCCTCC
 481 AGTTTGTCAAGAGTTGAAGGAGGCTCTGTGGCCAGGTGACCTGGCTGCCTTCCACTCCTTGTACCTCAGTCTAAACATGG
 561 AGTGGCCGCTGACAAGGCGCTCCAGCCCCAGAGCCAGCGTCTTCATGGGGAAGATGAATGGACCTGAGTAGCTGAAGGAA
 641 GGCCCCTCCCTACCCAAAGACTGGAGGCTTCTCAGCCTCAATTTCCCTGTCTGTACAGCTGAGGGCTCTGCCTGTCCCCC
 721 ACTGCTATCAGTATGGAACCCCAGCTGGGGTCCCCTATTGAGTGCCGACTCCCCCCACCGCCAGCAGCTGCTCCTCCAGC
 801 CACACCCCTCCTGCTCCCCCCACCCCTAGCCCTTGACCCTGGCTGGCCTGCCCCGCTCCACAGGCCACCAGATGGGCTCC
 881 TGAGACCCTCCCCAGGCTGCTTACAGCTCATTCTGCTGGGGGTAGAGATGAGGGGAGGGAGTAAGTTAAACCTTGGACTA
 961 GCAAGTAGAAGCCTGGGGGGATGCGTGTGCCTCAGTTTCCTCCTCCACAACTGAATATAGTGGCTGAAAACTGGGGAGAT
1041 ACTTGATGGCGCGAATGTCCGTTTTCTCTCCCTTCCCACCTCCTGCAGGAAGCAGGACGGGGCAGGCAGCACCTGGTAGG
1121 CACAGTGCTTTGCCCCTCCTCCCCTTCCCTTCTGGAAGTCTTGGGGCCTCAGTGCTTGCAACAGCCGGCCTTGGGCAAAT
1201 AAAAGACTAGGTTGTTTACTAGCCTTGCTTGGAGCTTCATCCTTGGAAACGGGTGGCACCTCATATCCCCCCAGCCGTGG
1281 TCTGTGATACAACCTCTCCATCCTCAGCCTAGGGCCTCAGAGCTACCCTTCACCCAAAAGAGGGGTGGGGGTGAACACTC
1361 AGACAATCTGAGAGGGGGTAGTCTAATAGAGCCATCTGGAGAAGGGAGTGGCAGAGCCAGTCTGTGCTGACCAGTCTGTG
1441 TCCCGGGACGCATCCCCACCCGTCTGTCCAAGGCTTTGTCCCACCAGCTGCAGCCAGCAGCCTCAGAACCCAAAATGAGG
1521 GTAGCATAGATAAGACTGCTGAGCCCCCTTTCTGTGGTCTTTCCTTTCCATGACCTAGAGAAAAGAGCTTTGCTGGAGGG
1601 AGACCCCCAAAAAGAATTAGGGTGCTAACATCCCACCAAAAGCATCATCCCACCCAAAATGTTGCTTTTCATTCTATGTC
1681 AATAATTTAAGGTGGAATTTCTCTCACCCTGTGGAGATGAAAGTGGCAAAAGGTTGTCCCAGCAGTGTTGGGGGATGGGG
1761 TGTGCACATCATTCTTTTGGGGGTAGATGACCTGCTGGCTGGTGGGCTTTTCTCCAGGACTACTGCAGGTAGAGACCCTC
1841 TGGGCTTGTGTGGAGTGGGAGCAGCCGTGTTGGGACTATGGGGAGGAGCTGGTCTGGGTGCAAATTAAGGCCAGTGTTGG
1921 GGTCTGAGTGCTGTCCAGAAAGGCTGTGTGACCAACCCTCACTAGTTCCTGAGGTCAGGGTCTCCATGTTAGGGAACAGA
2001 GCAAGAGACTTGGAACAGCTCCCTACAGCTGCACTTCTAGAAGGTCAGCCTGTCCGATTCTTGTAACCTGGAGGTCCCTC
2081 CCCATCTGCAGCCCCCTGAGCTGCAGGAGCGGCCCCATCAGTGCACCTGATTGGAACACACTAGATTTCAGGTCCTGGAA
2161 ACTGGGCGCTAGGATCCGTTTCCCTGGCTGCAGAGAGTGGGAGGTGTGATGTGGAATATCCCTTCTCCCAGCACACCCCA
2241 ATTAATACTGAAGAGTAGGGCAGGAGGAGGTGCTGGGAAAACCGGGTTTCTTGGCACATGGGGGTGCAAGCACTGTGGTT
2321 GAAATTGGCCATGTCCAAGGCACACCAGACGATTTCAGGTCATTTTTAGCCCTAGACTGGAAAGGGGTCAGGGGACAGGT
2401 GACCTGGGCTCAGCCCCCAGCAGCTCCCAACTGCCCCTCTCCCAAGCAACTCCTGATCCCTGCTTTTGAGGAAATAAACA
2481 AATAAAACCCCGCTATCTCCGAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gcugcACCCCGCCUCG--CAGACCUuc 5'
               ||||| |||||  ||||||:  
Target 5' gactaTGGGGAGGAGCTGGTCTGGGtg 3'
 1874 - 1900 146.00 -29.80
2 
miRNA  3' gcugcaccccgccucGCAGACCUUc 5'
                         | ||||||| 
Target 5' ccctcctccccttccCTTCTGGAAg 3'
 1134 - 1158 142.00 -11.90
3 
miRNA  3' gcugcaccccgcCUC-GCAGACCUUc 5'
                      ||| | ||||||: 
Target 5' ggtagtctaataGAGCCATCTGGAGa 3'
 1377 - 1402 133.00 -12.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31592236 29 COSMIC
COSN28881228 57 COSMIC
COSN16128667 108 COSMIC
COSN16128480 121 COSMIC
COSN30702656 132 COSMIC
COSN31552436 137 COSMIC
COSM8254442 151 COSMIC
COSM4936038 180 COSMIC
COSM8533847 189 COSMIC
COSM9342110 203 COSMIC
COSM4921095 216 COSMIC
COSN24303216 233 COSMIC
COSN30469206 247 COSMIC
COSN30471702 247 COSMIC
COSN30492753 259 COSMIC
COSN14373717 263 COSMIC
COSN30465570 280 COSMIC
COSN7557265 298 COSMIC
COSN30539677 332 COSMIC
COSN24311744 349 COSMIC
COSN30513730 389 COSMIC
COSN30543541 408 COSMIC
COSN7557266 411 COSMIC
COSN32063473 543 COSMIC
COSN20106645 1019 COSMIC
COSN8520003 1149 COSMIC
COSN26562595 1223 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1171299719 3 dbSNP
rs970062146 6 dbSNP
rs767515211 7 dbSNP
rs750569263 8 dbSNP
rs756256510 12 dbSNP
rs780198034 16 dbSNP
rs1411887987 23 dbSNP
rs78533174 27 dbSNP
rs41313335 38 dbSNP
rs1365979127 42 dbSNP
rs1231042171 43 dbSNP
rs762339326 46 dbSNP
rs1447430328 49 dbSNP
rs906389051 53 dbSNP
rs1194145869 55 dbSNP
rs143774094 71 dbSNP
rs1033616634 73 dbSNP
rs1188760043 76 dbSNP
rs920895329 77 dbSNP
rs1490671842 79 dbSNP
rs536714521 82 dbSNP
rs1165819183 95 dbSNP
rs1344728720 96 dbSNP
rs556671154 100 dbSNP
rs375067234 101 dbSNP
rs1050821088 102 dbSNP
rs372824048 107 dbSNP
rs772613378 109 dbSNP
rs778225263 111 dbSNP
rs539223531 112 dbSNP
rs745452451 117 dbSNP
rs1298488320 124 dbSNP
rs768237190 125 dbSNP
rs769337598 129 dbSNP
rs201991488 131 dbSNP
rs768154723 132 dbSNP
rs200421694 133 dbSNP
rs774219751 134 dbSNP
rs1372127877 135 dbSNP
rs767627771 138 dbSNP
rs750370980 142 dbSNP
rs1168107640 144 dbSNP
rs760631983 146 dbSNP
rs370747877 147 dbSNP
rs753817796 150 dbSNP
rs375604007 154 dbSNP
rs1251790061 155 dbSNP
rs1037252644 157 dbSNP
rs1180589664 159 dbSNP
rs1384893970 160 dbSNP
rs898347641 161 dbSNP
rs778977986 162 dbSNP
rs1331623594 165 dbSNP
rs753097631 166 dbSNP
rs1347081220 168 dbSNP
rs1200774973 174 dbSNP
rs922753956 179 dbSNP
rs932863980 188 dbSNP
rs1343639496 189 dbSNP
rs150966477 190 dbSNP
rs1482160463 191 dbSNP
rs749134712 193 dbSNP
rs1252607116 196 dbSNP
rs757642428 199 dbSNP
rs368570056 207 dbSNP
rs1407881001 209 dbSNP
rs370348671 210 dbSNP
rs1269900772 212 dbSNP
rs1379838312 212 dbSNP
rs748698395 213 dbSNP
rs768405680 214 dbSNP
rs374697837 216 dbSNP
rs748012287 217 dbSNP
rs772006352 223 dbSNP
rs140821387 224 dbSNP
rs1368121770 227 dbSNP
rs1478654731 230 dbSNP
rs773737651 231 dbSNP
rs773074614 234 dbSNP
rs760688992 236 dbSNP
rs1434332588 237 dbSNP
rs368000179 240 dbSNP
rs776817804 242 dbSNP
rs759500572 243 dbSNP
rs765565694 244 dbSNP
rs752905550 246 dbSNP
rs1427411205 248 dbSNP
rs1010345098 250 dbSNP
rs758561778 254 dbSNP
rs764451819 255 dbSNP
rs1335888241 257 dbSNP
rs751882648 262 dbSNP
rs1246761256 263 dbSNP
rs372210741 269 dbSNP
rs1189313018 274 dbSNP
rs373253256 275 dbSNP
rs1461404525 277 dbSNP
rs574075510 280 dbSNP
rs1438103068 288 dbSNP
rs1266868590 290 dbSNP
rs1226022410 291 dbSNP
rs1033978449 292 dbSNP
rs543148115 293 dbSNP
rs563036884 295 dbSNP
rs1161286599 296 dbSNP
rs1338979363 297 dbSNP
rs774510032 301 dbSNP
rs1453565522 303 dbSNP
rs974927091 311 dbSNP
rs748398460 312 dbSNP
rs114245612 319 dbSNP
rs1409405275 321 dbSNP
rs1368023436 328 dbSNP
rs1384673443 330 dbSNP
rs955017380 332 dbSNP
rs41276664 335 dbSNP
rs866165607 338 dbSNP
rs376181985 339 dbSNP
rs1350831675 342 dbSNP
rs939740048 344 dbSNP
rs1444808327 351 dbSNP
rs1275827326 356 dbSNP
rs1312149441 362 dbSNP
rs966704562 364 dbSNP
rs1245403291 365 dbSNP
rs972488657 366 dbSNP
rs773271761 370 dbSNP
rs1456702740 373 dbSNP
rs761148696 384 dbSNP
rs1209122552 388 dbSNP
rs976791341 389 dbSNP
rs1316821141 395 dbSNP
rs919726838 402 dbSNP
rs1178321623 403 dbSNP
rs931140340 409 dbSNP
rs1029714669 411 dbSNP
rs766601555 412 dbSNP
rs985649114 416 dbSNP
rs1323520871 417 dbSNP
rs559396719 426 dbSNP
rs962990930 427 dbSNP
rs1389216778 430 dbSNP
rs1186223290 433 dbSNP
rs777224994 444 dbSNP
rs140759094 456 dbSNP
rs1242119089 457 dbSNP
rs1198093396 464 dbSNP
rs547494584 466 dbSNP
rs1293852608 470 dbSNP
rs1223001934 471 dbSNP
rs1341170664 472 dbSNP
rs948101545 473 dbSNP
rs928970464 479 dbSNP
rs1362757385 489 dbSNP
rs1010708976 490 dbSNP
rs1046158456 502 dbSNP
rs1177030440 507 dbSNP
rs1021666796 521 dbSNP
rs1408085401 525 dbSNP
rs1409621371 531 dbSNP
rs1463850937 540 dbSNP
rs1369054007 548 dbSNP
rs768110617 561 dbSNP
rs369312970 563 dbSNP
rs927740464 565 dbSNP
rs937811045 568 dbSNP
rs904654606 569 dbSNP
rs1272606536 573 dbSNP
rs1476738108 578 dbSNP
rs996292400 579 dbSNP
rs1200001168 580 dbSNP
rs1482626085 582 dbSNP
rs1029144803 583 dbSNP
rs955108822 593 dbSNP
rs1224719592 594 dbSNP
rs1308364907 595 dbSNP
rs1010804190 599 dbSNP
rs1265528762 608 dbSNP
rs1325695151 611 dbSNP
rs1316516729 623 dbSNP
rs987758187 624 dbSNP
rs1409680588 628 dbSNP
rs1198417008 639 dbSNP
rs902494532 642 dbSNP
rs1439797953 643 dbSNP
rs1443380544 666 dbSNP
rs1196974545 679 dbSNP
rs1019666622 686 dbSNP
rs150093187 687 dbSNP
rs1029663886 688 dbSNP
rs1467796568 699 dbSNP
rs1480790033 700 dbSNP
rs1200127213 702 dbSNP
rs1177078154 717 dbSNP
rs1472192532 720 dbSNP
rs972439753 721 dbSNP
rs372900918 728 dbSNP
rs763607380 730 dbSNP
rs868185071 732 dbSNP
rs1007425054 748 dbSNP
rs1237137038 753 dbSNP
rs1431344267 755 dbSNP
rs1017083332 758 dbSNP
rs530099424 767 dbSNP
rs550336370 768 dbSNP
rs1046557713 771 dbSNP
rs979920463 777 dbSNP
rs927943489 778 dbSNP
rs375868791 780 dbSNP
rs1411347516 781 dbSNP
rs1283270121 787 dbSNP
rs1321155713 795 dbSNP
rs539235826 798 dbSNP
rs972949387 799 dbSNP
rs1407680030 800 dbSNP
rs570719469 806 dbSNP
rs918858807 807 dbSNP
rs114639179 817 dbSNP
rs1405025016 820 dbSNP
rs1057062096 822 dbSNP
rs1412714790 823 dbSNP
rs1181991215 825 dbSNP
rs913183917 826 dbSNP
rs946065502 829 dbSNP
rs1243971577 830 dbSNP
rs927656264 831 dbSNP
rs1463582993 832 dbSNP
rs1217082925 837 dbSNP
rs937774655 837 dbSNP
rs751127951 839 dbSNP
rs1310958573 840 dbSNP
rs1248612235 848 dbSNP
rs2240945 854 dbSNP
rs915068631 855 dbSNP
rs371423026 856 dbSNP
rs1208336588 862 dbSNP
rs1289409120 873 dbSNP
rs1042263248 875 dbSNP
rs1490552094 877 dbSNP
rs1224818673 885 dbSNP
rs1349214492 886 dbSNP
rs902442420 889 dbSNP
rs996238190 896 dbSNP
rs1261045043 897 dbSNP
rs554949609 899 dbSNP
rs1386148108 909 dbSNP
rs1476820104 922 dbSNP
rs998108151 923 dbSNP
rs780030329 925 dbSNP
rs1187631062 928 dbSNP
rs1488475114 932 dbSNP
rs1051099870 933 dbSNP
rs890640426 936 dbSNP
rs1476265238 942 dbSNP
rs1227124850 943 dbSNP
rs1009528051 957 dbSNP
rs1006961815 962 dbSNP
rs1382292473 965 dbSNP
rs1017446535 973 dbSNP
rs1384231036 978 dbSNP
rs1301192902 980 dbSNP
rs1424840504 981 dbSNP
rs1168205649 984 dbSNP
rs962885851 984 dbSNP
rs574137546 985 dbSNP
rs141115931 986 dbSNP
rs962649552 988 dbSNP
rs1267445103 991 dbSNP
rs1202170141 993 dbSNP
rs754026881 996 dbSNP
rs1251469784 1007 dbSNP
rs1194421608 1013 dbSNP
rs993827512 1014 dbSNP
rs1243059552 1015 dbSNP
rs201525896 1015 dbSNP
rs200432145 1016 dbSNP
rs3217091 1016 dbSNP
rs199707278 1018 dbSNP
rs1360450594 1021 dbSNP
rs1311052769 1032 dbSNP
rs556641571 1035 dbSNP
rs1281336471 1038 dbSNP
rs1026682019 1043 dbSNP
rs1225197502 1043 dbSNP
rs1345928495 1044 dbSNP
rs1034675808 1051 dbSNP
rs1389460270 1052 dbSNP
rs1248401502 1053 dbSNP
rs576489571 1054 dbSNP
rs952422073 1058 dbSNP
rs750022870 1061 dbSNP
rs147022760 1062 dbSNP
rs779676534 1069 dbSNP
rs959908622 1074 dbSNP
rs1439896708 1077 dbSNP
rs1252258062 1078 dbSNP
rs1195980832 1085 dbSNP
rs753276978 1088 dbSNP
rs993109268 1098 dbSNP
rs913140019 1099 dbSNP
rs879231322 1100 dbSNP
rs1236681430 1102 dbSNP
rs1185161933 1104 dbSNP
rs749257705 1114 dbSNP
rs1395608170 1128 dbSNP
rs1404162112 1135 dbSNP
rs559469457 1139 dbSNP
rs754908990 1140 dbSNP
rs933891076 1149 dbSNP
rs572929921 1151 dbSNP
rs1048340 1153 dbSNP
rs1388610585 1154 dbSNP
rs1157290338 1155 dbSNP
rs1471379232 1159 dbSNP
rs1048354 1161 dbSNP
rs1043019971 1162 dbSNP
rs1182099022 1167 dbSNP
rs1051482039 1174 dbSNP
rs1240882910 1178 dbSNP
rs542139776 1179 dbSNP
rs1205063811 1182 dbSNP
rs561952372 1187 dbSNP
rs185888387 1188 dbSNP
rs1038415436 1203 dbSNP
rs1452413224 1205 dbSNP
rs35885713 1208 dbSNP
rs1050539275 1210 dbSNP
rs890578341 1218 dbSNP
rs1159716707 1230 dbSNP
rs1261149797 1236 dbSNP
rs746774559 1237 dbSNP
rs1380904702 1238 dbSNP
rs1394739364 1240 dbSNP
rs1453499750 1243 dbSNP
rs994285528 1251 dbSNP
rs772253835 1256 dbSNP
rs1025818189 1260 dbSNP
rs907395668 1261 dbSNP
rs898065533 1269 dbSNP
rs1386299679 1270 dbSNP
rs1003115895 1272 dbSNP
rs1423122537 1273 dbSNP
rs550150553 1275 dbSNP
rs1184985958 1276 dbSNP
rs1444716541 1277 dbSNP
rs773503308 1278 dbSNP
rs1307336261 1285 dbSNP
rs1026628212 1288 dbSNP
rs952372120 1294 dbSNP
rs1190374029 1300 dbSNP
rs758639973 1303 dbSNP
rs555753579 1307 dbSNP
rs1221545179 1314 dbSNP
rs771329624 1323 dbSNP
rs1262510501 1328 dbSNP
rs1294223531 1336 dbSNP
rs1352777806 1336 dbSNP
rs1198619492 1338 dbSNP
rs1338849865 1343 dbSNP
rs776802294 1355 dbSNP
rs1262318942 1360 dbSNP
rs1432936021 1360 dbSNP
rs960092965 1361 dbSNP
rs1303058496 1363 dbSNP
rs1403501895 1365 dbSNP
rs868527368 1367 dbSNP
rs977835055 1372 dbSNP
rs913079133 1373 dbSNP
rs1235970313 1374 dbSNP
rs1418316487 1375 dbSNP
rs1165721845 1377 dbSNP
rs377012109 1378 dbSNP
rs986710956 1386 dbSNP
rs565067958 1389 dbSNP
rs1198519053 1395 dbSNP
rs978660513 1409 dbSNP
rs1489807539 1411 dbSNP
rs1364974157 1417 dbSNP
rs911131261 1443 dbSNP
rs925918899 1445 dbSNP
rs532612779 1446 dbSNP
rs931985282 1450 dbSNP
rs986577971 1451 dbSNP
rs1283205027 1453 dbSNP
rs138184459 1462 dbSNP
rs930029178 1463 dbSNP
rs370371883 1467 dbSNP
rs1353622355 1468 dbSNP
rs1326381671 1485 dbSNP
rs1372890247 1487 dbSNP
rs1411162181 1496 dbSNP
rs1423673778 1502 dbSNP
rs143664445 1521 dbSNP
rs1431309886 1527 dbSNP
rs190168332 1533 dbSNP
rs145917322 1540 dbSNP
rs1231407277 1546 dbSNP
rs930853754 1562 dbSNP
rs1034569862 1563 dbSNP
rs368192853 1574 dbSNP
rs761363025 1579 dbSNP
rs1326366480 1581 dbSNP
rs1284471618 1588 dbSNP
rs1420967727 1589 dbSNP
rs1001192432 1598 dbSNP
rs570467171 1601 dbSNP
rs895548756 1611 dbSNP
rs1255850985 1612 dbSNP
rs967716083 1620 dbSNP
rs1443863470 1622 dbSNP
rs1195978313 1630 dbSNP
rs1272286534 1643 dbSNP
rs1252112137 1644 dbSNP
rs1430939833 1660 dbSNP
rs1014438364 1662 dbSNP
rs182426410 1663 dbSNP
rs967190386 1673 dbSNP
rs1399897832 1675 dbSNP
rs978608305 1677 dbSNP
rs1481672413 1683 dbSNP
rs1470660589 1695 dbSNP
rs1242760069 1697 dbSNP
rs1181889372 1702 dbSNP
rs1169015011 1709 dbSNP
rs148331426 1712 dbSNP
rs1264312195 1719 dbSNP
rs1315531409 1720 dbSNP
rs1286842495 1724 dbSNP
rs570233262 1728 dbSNP
rs141444537 1729 dbSNP
rs1462721951 1747 dbSNP
rs953331289 1752 dbSNP
rs374155409 1754 dbSNP
rs1449848103 1761 dbSNP
rs986137434 1763 dbSNP
rs911906603 1767 dbSNP
rs750123992 1768 dbSNP
rs755659465 1771 dbSNP
rs1303386267 1773 dbSNP
rs944787870 1775 dbSNP
rs546948330 1780 dbSNP
rs972571495 1782 dbSNP
rs1404406687 1792 dbSNP
rs1452901665 1794 dbSNP
rs919391417 1798 dbSNP
rs1343335618 1801 dbSNP
rs2240944 1815 dbSNP
rs1346082034 1816 dbSNP
rs150827739 1819 dbSNP
rs905430986 1821 dbSNP
rs938286555 1830 dbSNP
rs1256895289 1835 dbSNP
rs919914540 1836 dbSNP
rs1306685536 1857 dbSNP
rs1055440269 1860 dbSNP
rs1244331483 1861 dbSNP
rs75629323 1867 dbSNP
rs1359096045 1868 dbSNP
rs1047156882 1870 dbSNP
rs1290580881 1881 dbSNP
rs1243268370 1883 dbSNP
rs928708535 1886 dbSNP
rs1360998084 1888 dbSNP
rs1013968649 1892 dbSNP
rs1312865032 1898 dbSNP
rs1359858221 1899 dbSNP
rs1290502229 1905 dbSNP
rs1400392135 1914 dbSNP
rs1364691574 1915 dbSNP
rs1252700684 1922 dbSNP
rs938830218 1923 dbSNP
rs1426846088 1924 dbSNP
rs113086733 1939 dbSNP
rs1169912459 1947 dbSNP
rs762578971 1956 dbSNP
rs1426797925 1958 dbSNP
rs894682291 1959 dbSNP
rs1221111744 1981 dbSNP
rs1490296976 1985 dbSNP
rs1267146620 1987 dbSNP
rs1225153048 1993 dbSNP
rs1019992584 1997 dbSNP
rs902978323 2002 dbSNP
rs1226078889 2008 dbSNP
rs1305193768 2010 dbSNP
rs1268919334 2018 dbSNP
rs999147978 2021 dbSNP
rs866180391 2024 dbSNP
rs999979341 2040 dbSNP
rs955290719 2049 dbSNP
rs1301106769 2054 dbSNP
rs1406536998 2055 dbSNP
rs1032837513 2056 dbSNP
rs953280882 2057 dbSNP
rs1297763767 2064 dbSNP
rs1460531997 2092 dbSNP
rs1356311476 2093 dbSNP
rs116967727 2095 dbSNP
rs1427773465 2097 dbSNP
rs774190847 2097 dbSNP
rs1434070421 2103 dbSNP
rs201130942 2108 dbSNP
rs1194839221 2111 dbSNP
rs151141817 2111 dbSNP
rs187942668 2120 dbSNP
rs192221871 2124 dbSNP
rs2240943 2126 dbSNP
rs532388503 2136 dbSNP
rs966449033 2145 dbSNP
rs1198690345 2163 dbSNP
rs1322820332 2166 dbSNP
rs10124503 2168 dbSNP
rs1225130058 2172 dbSNP
rs559591272 2173 dbSNP
rs116246421 2174 dbSNP
rs928654563 2176 dbSNP
rs1367482997 2177 dbSNP
rs548335525 2178 dbSNP
rs1469346491 2179 dbSNP
rs184074843 2185 dbSNP
rs926796479 2187 dbSNP
rs1363535614 2189 dbSNP
rs371545217 2190 dbSNP
rs538789986 2197 dbSNP
rs1180081623 2199 dbSNP
rs1361099051 2200 dbSNP
rs1178775186 2209 dbSNP
rs1214951039 2210 dbSNP
rs531082096 2221 dbSNP
rs1057123183 2235 dbSNP
rs34688153 2236 dbSNP
rs1261181225 2242 dbSNP
rs1345477273 2247 dbSNP
rs537956542 2247 dbSNP
rs1356853084 2262 dbSNP
rs1244739459 2267 dbSNP
rs1236570780 2274 dbSNP
rs1379476144 2278 dbSNP
rs916880957 2281 dbSNP
rs747267090 2284 dbSNP
rs546978601 2287 dbSNP
rs1055912152 2295 dbSNP
rs1291921837 2295 dbSNP
rs1339299025 2302 dbSNP
rs1360950349 2307 dbSNP
rs949747241 2316 dbSNP
rs1214349803 2318 dbSNP
rs1242040313 2326 dbSNP
rs1157261788 2328 dbSNP
rs1455661447 2332 dbSNP
rs1486441357 2341 dbSNP
rs916035999 2345 dbSNP
rs1158804157 2351 dbSNP
rs1188668075 2363 dbSNP
rs947597657 2364 dbSNP
rs771116198 2374 dbSNP
rs550839131 2378 dbSNP
rs1203181993 2384 dbSNP
rs1444267434 2390 dbSNP
rs999927007 2390 dbSNP
rs1164413931 2407 dbSNP
rs761093937 2414 dbSNP
rs766426224 2418 dbSNP
rs1043248766 2427 dbSNP
rs570854585 2428 dbSNP
rs999095545 2438 dbSNP
rs1158398939 2448 dbSNP
rs539051351 2451 dbSNP
rs1326418244 2459 dbSNP
rs1344553050 2460 dbSNP
rs1316782748 2461 dbSNP
rs1384277974 2476 dbSNP
rs1052046055 2480 dbSNP
rs1431326755 2480 dbSNP
rs1423657077 2489 dbSNP
rs755153726 2490 dbSNP
rs138173359 2493 dbSNP
rs1290445356 2501 dbSNP
rs888962138 2503 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_030914 | 3UTR | UUUGCCCCUCCUCCCCUUCCCUUCUGGAAGUCUUGGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_030914 | 3UTR | ACAGUGCUUUGCCCCUCCUCCCCUUCCCUUCUGGAAGUCUUGGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_030914 | 3UTR | CUGGUAGGCACAGUGCUUUGCCCCUCCUCCCCUUCCCUUCUGGAAGUCUUGGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_030914 | 3UTR | CACAGUGCUUUGCCCCUCCUCCCCUUCCCUUCUGGAAGUCUUGGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_030914 | 3UTR | CCUGGUAGGCACAGUGCUUUGCCCCUCCUCCCCUUCCCUUCUGGAAGUCUUGGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000372850.1 | 3UTR | CUUUGCCCCUCCUCCCCUUCCCUUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
126 hsa-miR-3180-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT088042 UBXN2A UBX domain protein 2A 2 2
MIRT092741 SETD5 SET domain containing 5 2 4
MIRT123870 FZD6 frizzled class receptor 6 2 2
MIRT134588 GXYLT1 glucoside xylosyltransferase 1 2 2
MIRT174919 RNF38 ring finger protein 38 2 2
MIRT232088 CCSAP centriole, cilia and spindle associated protein 2 2
MIRT257503 HIST1H2AH histone cluster 1 H2A family member h 2 2
MIRT332968 CELF1 CUGBP Elav-like family member 1 2 4
MIRT441902 SEPN1 selenoprotein N 2 2
MIRT443231 ALG8 ALG8, alpha-1,3-glucosyltransferase 2 2
MIRT446243 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT447999 GPR63 G protein-coupled receptor 63 2 2
MIRT458203 FOXL2 forkhead box L2 2 2
MIRT461680 ZNF426 zinc finger protein 426 2 2
MIRT462650 HMOX1 heme oxygenase 1 2 4
MIRT462850 UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2 2
MIRT464366 URM1 ubiquitin related modifier 1 2 2
MIRT466852 STX6 syntaxin 6 2 2
MIRT468228 SGK1 serum/glucocorticoid regulated kinase 1 2 2
MIRT472037 NPAT nuclear protein, coactivator of histone transcription 2 2
MIRT481535 ARL5B ADP ribosylation factor like GTPase 5B 2 2
MIRT482639 RPL18A ribosomal protein L18a 2 2
MIRT498085 SEMA7A semaphorin 7A (John Milton Hagen blood group) 2 2
MIRT498273 POFUT1 protein O-fucosyltransferase 1 2 2
MIRT506560 MNX1 motor neuron and pancreas homeobox 1 2 4
MIRT507153 GATA6 GATA binding protein 6 2 4
MIRT507447 EIF6 eukaryotic translation initiation factor 6 2 2
MIRT507565 DEK DEK proto-oncogene 2 2
MIRT519629 ZNF772 zinc finger protein 772 2 4
MIRT527689 IL17REL interleukin 17 receptor E like 2 2
MIRT528200 NELFE negative elongation factor complex member E 2 2
MIRT528528 CYP2C19 cytochrome P450 family 2 subfamily C member 19 2 4
MIRT528871 ATF3 activating transcription factor 3 2 2
MIRT529121 HOMEZ homeobox and leucine zipper encoding 2 2
MIRT529479 TPD52L3 tumor protein D52 like 3 2 2
MIRT530757 ZNF582 zinc finger protein 582 2 2
MIRT530897 C9orf3 chromosome 9 open reading frame 3 2 2
MIRT531495 NONO non-POU domain containing octamer binding 2 2
MIRT531927 IL12RB2 interleukin 12 receptor subunit beta 2 2 2
MIRT532343 PLEK pleckstrin 2 2
MIRT532817 ZNF827 zinc finger protein 827 2 2
MIRT533516 TRIM13 tripartite motif containing 13 2 2
MIRT534275 SLC12A7 solute carrier family 12 member 7 2 2
MIRT534480 SAR1B secretion associated Ras related GTPase 1B 2 2
MIRT537351 FJX1 four jointed box 1 2 2
MIRT538799 C2CD5 C2 calcium dependent domain containing 5 2 2
MIRT538842 BTG1 BTG anti-proliferation factor 1 2 2
MIRT539266 ANKRD28 ankyrin repeat domain 28 2 2
MIRT543401 ANAPC13 anaphase promoting complex subunit 13 2 2
MIRT552637 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT556033 MXD1 MAX dimerization protein 1 2 2
MIRT556449 LMNB2 lamin B2 2 4
MIRT562448 CSDE1 cold shock domain containing E1 2 2
MIRT567281 HNRNPL heterogeneous nuclear ribonucleoprotein L 2 2
MIRT574050 PROSC pyridoxal phosphate binding protein 2 2
MIRT575658 Map1b microtubule-associated protein 1B 2 2
MIRT606823 APBB2 amyloid beta precursor protein binding family B member 2 2 2
MIRT609583 GPM6B glycoprotein M6B 2 2
MIRT609678 TMEM213 transmembrane protein 213 2 2
MIRT611221 ZNF274 zinc finger protein 274 2 2
MIRT612577 SYNGAP1 synaptic Ras GTPase activating protein 1 2 4
MIRT613583 MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 2 2
MIRT614394 C11orf45 chromosome 11 open reading frame 45 2 2
MIRT615558 JPH2 junctophilin 2 2 2
MIRT615850 RASGRP1 RAS guanyl releasing protein 1 2 2
MIRT615906 C1orf27 chromosome 1 open reading frame 27 2 2
MIRT615932 MAP1LC3B microtubule associated protein 1 light chain 3 beta 2 2
MIRT617632 RXRA retinoid X receptor alpha 2 2
MIRT618745 CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2 2
MIRT622073 SRPX2 sushi repeat containing protein, X-linked 2 2 2
MIRT624390 CD3D CD3d molecule 2 2
MIRT634656 GRIN2B glutamate ionotropic receptor NMDA type subunit 2B 2 2
MIRT636717 AQR aquarius intron-binding spliceosomal factor 2 2
MIRT638033 SHPK sedoheptulokinase 2 2
MIRT638543 KIAA1549 KIAA1549 2 2
MIRT638754 EPHA4 EPH receptor A4 2 2
MIRT639223 IMMP2L inner mitochondrial membrane peptidase subunit 2 2 2
MIRT641774 ZFP91 ZFP91 zinc finger protein 2 2
MIRT643672 CEP78 centrosomal protein 78 2 2
MIRT645851 AFF2 AF4/FMR2 family member 2 2 2
MIRT646021 S100A7A S100 calcium binding protein A7A 2 2
MIRT646071 NDUFS2 NADH:ubiquinone oxidoreductase core subunit S2 2 2
MIRT646730 FADS1 fatty acid desaturase 1 2 2
MIRT646742 MUC4 mucin 4, cell surface associated 2 2
MIRT647563 ZNF660 zinc finger protein 660 2 2
MIRT648539 TMEM169 transmembrane protein 169 2 2
MIRT650852 UNC13D unc-13 homolog D 2 2
MIRT650872 PPP1R15A protein phosphatase 1 regulatory subunit 15A 2 2
MIRT652345 TMOD3 tropomodulin 3 2 2
MIRT653451 SLC6A17 solute carrier family 6 member 17 2 2
MIRT654750 PRKCB protein kinase C beta 2 2
MIRT655569 OXSR1 oxidative stress responsive 1 2 2
MIRT656547 LZIC leucine zipper and CTNNBIP1 domain containing 2 2
MIRT657212 IGF1R insulin like growth factor 1 receptor 2 2
MIRT657740 GNG12 G protein subunit gamma 12 2 2
MIRT659225 CXorf23 BCLAF1 and THRAP3 family member 3 2 2
MIRT659272 CTNNBIP1 catenin beta interacting protein 1 2 2
MIRT660822 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT666123 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT666608 REEP2 receptor accessory protein 2 2 2
MIRT668974 CLSTN2 calsyntenin 2 2 2
MIRT678890 TTLL12 tubulin tyrosine ligase like 12 2 2
MIRT683998 FOLR1 folate receptor 1 2 2
MIRT685672 PSMB7 proteasome subunit beta 7 2 2
MIRT689095 ZBTB25 zinc finger and BTB domain containing 25 2 2
MIRT690645 RPF2 ribosome production factor 2 homolog 2 2
MIRT697740 USP5 ubiquitin specific peptidase 5 2 2
MIRT698823 STARD7 StAR related lipid transfer domain containing 7 2 2
MIRT699886 RUNX1 runt related transcription factor 1 2 2
MIRT700010 RPP25 ribonuclease P and MRP subunit p25 2 2
MIRT706001 ABCC1 ATP binding cassette subfamily C member 1 2 2
MIRT708394 XKR7 XK related 7 2 2
MIRT708517 TOP2B DNA topoisomerase II beta 2 2
MIRT709215 PARD3B par-3 family cell polarity regulator beta 2 2
MIRT710154 MTRF1L mitochondrial translational release factor 1 like 2 2
MIRT711069 NLGN2 neuroligin 2 2 2
MIRT714631 TM4SF18 transmembrane 4 L six family member 18 2 2
MIRT715418 SPOPL speckle type BTB/POZ protein like 2 2
MIRT716612 RBM18 RNA binding motif protein 18 2 2
MIRT718658 HNF4A hepatocyte nuclear factor 4 alpha 2 2
MIRT718929 TRIM66 tripartite motif containing 66 2 2
MIRT720637 ELF5 E74 like ETS transcription factor 5 2 2
MIRT720782 PRKRIP1 PRKR interacting protein 1 2 2
MIRT721285 TRABD2A TraB domain containing 2A 2 2
MIRT721337 LIF LIF, interleukin 6 family cytokine 2 2
MIRT722891 LRRC20 leucine rich repeat containing 20 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-3180-5p Ginsenoside Rh2 NULL 119307 Microarray NSCLC cell line A549 23152132 2013 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3180 Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-3180 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-3180 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3180 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-3180 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-3180 Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-3180 Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (AsPC-1)
hsa-miR-3180 Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (MGC803)
hsa-miR-3180 Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-3180 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-3180 Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)
hsa-miR-3180 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-3180 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-3180 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3180-5p Paclitaxel 36314 NSC125973 approved sensitive High Non-Small Cell Lung Cancer cell line (H460)
hsa-miR-3180-5p Docetaxel 148124 NSC628503 approved resistant High Breast Cancer cell line (MDA-MB-231, MCF-7)
hsa-miR-3180-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-3180-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-3180-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-3180-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3180-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-3180-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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