miRTarBase - #MIRT464551


—
pre-miRNA Information
pre-miRNA hsa-mir-4651   
Genomic Coordinates chr7: 75915197 - 75915269
Description Homo sapiens miR-4651 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4651
Sequence 10| CGGGGUGGGUGAGGUCGGGC |29
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30595227 5 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1458858872 1 dbSNP
rs887877274 2 dbSNP
rs559953168 4 dbSNP
rs1332072774 12 dbSNP
rs868980356 12 dbSNP
rs1291879524 14 dbSNP
rs1228835859 19 dbSNP
rs1349605668 19 dbSNP
rs1277626081 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol UBTF   
Synonyms NOR-90, UBF, UBF-1, UBF1, UBF2
Description upstream binding transcription factor, RNA polymerase I
Transcript NM_001076683   
Other Transcripts NM_001076684 , NM_014233   
Expression
Putative miRNA Targets on UBTF
3'UTR of UBTF
(miRNA target sites are highlighted)		 
>UBTF|NM_001076683|3'UTR
   1 GGCTCAGCCCCACCCCAGGGCAGCCAGGGAGAGCCCAGGAGCTCCCCTCCCCAACTGACCACCTTTGTTTCTCCCCCATG
  81 TTCTGTCCCTTGCCCCCCTGGCCTCCCCCACTTTCTTTCTTTCTTTAAAAAAAAAAAAAAATACGGTGGGGGTAGGGGGC
 161 TGGAGGAGCCCAGGCCAGGACTCTGCAGCCTCAGAGACATCAGCCCTTGGGGGTCCTCCTCCAGGGACAGCAACTATCAG
 241 ACTAAGCCAGCACCGGACCAGCCTGGCCCACCCCACCCACTTCTGCACTTGCGGTTCCGGCATGGACAATGGACCGGAGA
 321 GTGGGGGTGGGGGGTCCCAAAGAGTTTGATGAGGCCCTCCACACCTGCGGCCCAATCCAAGGTGGGGTGGAAGCTTGGGG
 401 AAGACCCATTCCTTCCCAGAGGGGCCTGCCACCTGGACCCCTGCATTGGAACTGGAGGCAGGGAACATGGGGAGGAGGAG
 481 GGTCGGTGCCTTCAAGAAAACAGGCACTGCCCTGGTGGCCCTCTCCCCTGCCCCCTGCAGGAAGGAGCTGCCTGGACCCG
 561 TTCATGGGGGAGGGGGCAGAAGTGTTTTTTATATATGTGTATATATTTTTTTTTAAGCTCTGAGCTGTCAACGAGACGTT
 641 TCCTACCGATCTCGGCTGCCGTCTCTGTTGTCATTTCTGGGAGAGGGAGGGTTTAGGGGTAGATTTGGAACCTTTTAAAA
 721 ATGGTCTTGATGTATGTGGAAGAGAGTATGTGTATGTGTGTTCCTGTACATAGCATGGGTGCAGCTGTGGATGTGTGCAA
 801 AAGAGTGTGAGTGTGTGTGTGTGTGTGTAAAGGGGTCTGTCCTAGAGCCCACATCAGTTTGTTGTGAATCTGGAAAAAGG
 881 GTCGGTGAGGGCCGGGAGATGTTGACCCTGGTGGGAGCAGGCTGAGGCTGCCCCGTTCTCCACATCCTCTGTTTTGCCCA
 961 GTCTCTGATTCCATTAGGGGGAGTGTGCTGAAGCCATTCTCGGATGCTTCCCAGACCAGGCTCCCTCTGCCAGAGTCACA
1041 TGCATCCGAGCTGCTGGTCTCCATTGTCCAGCAGGAAGGCGGAAAGGCAGGCAAGATGGTGTGAAGCTTAAAGCTTGTAT
1121 TTGATGGAAAAGGTCTCCCCTGTTCATCTGAGAGGCCAAGCCTGGCCACCCCAGGCTCAGAACCTGGGCTTCAAGAAATG
1201 TGCTGGGAGCTCCTAACTTACACATCCCTCCAGCCTTCCTTGAATCCTCCCACCACCCCCTATTTCCTTTAATTTCTCAG
1281 GTCTGCTCCCTCCTCCCCCAACCCCACAGCTGGGCAAGAAGTCTGCAAAAGCTGCATCTGCAGCTGTCTCTAACTCTTCC
1361 CAGCCATCTCCCGTATTTTTTGGTACCTTGATTCCTTGACTCTTAATAAGCCAAGCCACCTTATCTCTGTAGTTCTTATT
1441 TTTTTGTTGACTAAATTTGGGGGGTTCTTTTTTATGGTCATGTCACTGACCTATTAAATTGGGGCTTGGTGCTTTTCCAC
1521 CTTCCCCCTCTGAATGAAAGCCAAGGAATGGGGGAAGAGCGGGAACTCTGCCGCGGAGGTGGAGCAAGAACGGTGAAGGG
1601 CCCTGGTCCCAGAGAGGCTGGTGGGTCCCTCTCCCAAAGGAAGGCAGACAGTCTCTGCTTTGCCTTGGACCTTGGTGCTG
1681 GGGGTGGGGAGGCCTGGGGGGGACACTCCCCACTCCCATTCCCCTTCCTTTGTCCTAATCCTGGAATTAAGTACAGGGGT
1761 TTATAGGTTCTATTTCTTCCCAAGAGCCCTGCAAAGAACCCCAGTTTCCTATTTGGATGCCCCTACACTGTTGTGTTTCA
1841 GTGGAATGTATTTTCATTTAAAAACAACTTTGAATGGGGCACTTTTTCTTTCCTGTTTTAAAAATTGAAAAATTCTTACA
1921 GTACAAACAGGACTGTCAGGGTGGGGGTGTTGGTGCTGTAAGAGGTCACTCTTGAGTGCATTTTGGCACTGGGATGGGAT
2001 GGCTGGGGTGGGAAGACCCCCATCCCCACCCCCAACTTCTTTTCTAATATTTAAGGAGTGTTTTGTAGGATTCAACAACC
2081 ACCACAACTTGAATTTGTATCATGGGAGGTGGGAGGGAGTGGCTTAGAGGTGTCTGCCTATGCTTAAAGCCAACTGTGGA
2161 AGTTTTGTTTTCCCTTTTTTGTATAATAAAGTGAAAAACAAAGGTTTGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
2241 A
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cgGGCUGGAGUGGGUGGGGc 5'
            || :||| :|||||||| 
Target 5' gaCCAGCCTGGCCCACCCCa 3'
 256 - 275 166.00 -28.30
2 
miRNA  3' cgGGCU--GGAGUG-GGUGGGGc 5'
            ::||  |||| | ||||||| 
Target 5' ccTTGAATCCTCCCACCACCCCc 3'
 1238 - 1260 156.00 -23.00
3 
miRNA  3' cgggcugGAGU--GGGUGGGGc 5'
                 ||||  |||||||| 
Target 5' -----ggCTCAGCCCCACCCCa 3'
 1 - 17 155.00 -20.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30455912 11 COSMIC
COSN4622666 20 COSMIC
COSN30473083 27 COSMIC
COSN7812720 47 COSMIC
COSN30524122 51 COSMIC
COSN23843802 87 COSMIC
COSN1197233 127 COSMIC
COSN26548197 526 COSMIC
COSN26563639 548 COSMIC
COSN31579000 605 COSMIC
COSN31555700 607 COSMIC
COSN30543969 730 COSMIC
COSN29036550 810 COSMIC
COSN9669445 887 COSMIC
COSN18972964 926 COSMIC
COSN22024291 1488 COSMIC
COSN7435858 1666 COSMIC
COSN7435857 1703 COSMIC
COSN31490284 1915 COSMIC
COSN31515775 1915 COSMIC
COSN31563280 2003 COSMIC
COSN31608808 2047 COSMIC
COSN31577382 2142 COSMIC
rs9910055 1573 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs572638952 1 dbSNP
rs1265946955 2 dbSNP
rs906051185 4 dbSNP
rs770607035 5 dbSNP
rs1185159203 6 dbSNP
rs760152795 7 dbSNP
rs1044566914 9 dbSNP
rs770642757 11 dbSNP
rs377318867 13 dbSNP
rs138321189 14 dbSNP
rs1326593392 18 dbSNP
rs200826893 20 dbSNP
rs748055414 26 dbSNP
rs991881928 27 dbSNP
rs755405644 35 dbSNP
rs1299111150 36 dbSNP
rs1336906138 41 dbSNP
rs1381408521 44 dbSNP
rs1386090475 44 dbSNP
rs1394973396 51 dbSNP
rs1407861849 52 dbSNP
rs768525090 54 dbSNP
rs749128923 55 dbSNP
rs191365085 57 dbSNP
rs747564580 57 dbSNP
rs1388247613 58 dbSNP
rs1159358193 59 dbSNP
rs756454628 67 dbSNP
rs1375930444 69 dbSNP
rs1198789598 71 dbSNP
rs1455046583 74 dbSNP
rs745931206 75 dbSNP
rs1295206884 78 dbSNP
rs966720238 78 dbSNP
rs1198473391 79 dbSNP
rs781265823 80 dbSNP
rs145623357 87 dbSNP
rs1283202685 89 dbSNP
rs1205286374 92 dbSNP
rs752054456 93 dbSNP
rs552987056 94 dbSNP
rs753105726 95 dbSNP
rs765999022 97 dbSNP
rs776106868 99 dbSNP
rs146797528 100 dbSNP
rs569660738 102 dbSNP
rs1432712005 104 dbSNP
rs772748372 105 dbSNP
rs1037256676 108 dbSNP
rs1386207819 109 dbSNP
rs2229285 109 dbSNP
rs992321212 110 dbSNP
rs1434634002 113 dbSNP
rs1285308881 114 dbSNP
rs1343839232 119 dbSNP
rs1232869319 121 dbSNP
rs1255191595 123 dbSNP
rs1351830417 126 dbSNP
rs1283738260 127 dbSNP
rs1324381589 127 dbSNP
rs1487942132 133 dbSNP
rs1199474248 137 dbSNP
rs75104069 140 dbSNP
rs1431085797 141 dbSNP
rs1197806076 142 dbSNP
rs1360404189 142 dbSNP
rs1455613633 142 dbSNP
rs374363130 142 dbSNP
rs1425890145 143 dbSNP
rs1400196264 144 dbSNP
rs1388738411 145 dbSNP
rs956877320 147 dbSNP
rs918229577 152 dbSNP
rs1307907862 153 dbSNP
rs1337776894 154 dbSNP
rs886128047 156 dbSNP
rs536050870 163 dbSNP
rs1412486599 166 dbSNP
rs962584698 176 dbSNP
rs1198412360 181 dbSNP
rs1223213347 182 dbSNP
rs1018092575 184 dbSNP
rs1293318842 189 dbSNP
rs1487179002 192 dbSNP
rs1476867978 196 dbSNP
rs1208736308 203 dbSNP
rs1248112427 205 dbSNP
rs1250726153 208 dbSNP
rs1177124951 213 dbSNP
rs1221766555 214 dbSNP
rs985252589 216 dbSNP
rs955495278 221 dbSNP
rs1367251767 223 dbSNP
rs1038826495 226 dbSNP
rs565700500 233 dbSNP
rs944550960 237 dbSNP
rs1030164735 243 dbSNP
rs1398874056 249 dbSNP
rs750548177 254 dbSNP
rs547888617 255 dbSNP
rs891805822 258 dbSNP
rs1032991739 260 dbSNP
rs1000476443 261 dbSNP
rs906103526 262 dbSNP
rs1314705417 264 dbSNP
rs1044621655 268 dbSNP
rs532524933 273 dbSNP
rs1243377365 275 dbSNP
rs950197825 277 dbSNP
rs1458798783 280 dbSNP
rs966689049 285 dbSNP
rs895949646 292 dbSNP
rs1056628569 293 dbSNP
rs1462001904 294 dbSNP
rs989970877 298 dbSNP
rs929717460 299 dbSNP
rs959448498 300 dbSNP
rs1034189829 306 dbSNP
rs1003683329 309 dbSNP
rs970887398 311 dbSNP
rs1015778184 312 dbSNP
rs866503221 315 dbSNP
rs117467674 316 dbSNP
rs1175543432 317 dbSNP
rs772763701 323 dbSNP
rs1304401294 326 dbSNP
rs1048758664 327 dbSNP
rs770968010 328 dbSNP
rs1376843043 333 dbSNP
rs994912716 342 dbSNP
rs911135706 344 dbSNP
rs1191437568 346 dbSNP
rs985306201 355 dbSNP
rs955216334 356 dbSNP
rs944538817 357 dbSNP
rs573747907 359 dbSNP
rs149845965 362 dbSNP
rs989321188 368 dbSNP
rs1042322005 369 dbSNP
rs1212648456 371 dbSNP
rs945316672 380 dbSNP
rs915166647 389 dbSNP
rs989464660 398 dbSNP
rs959647722 410 dbSNP
rs956133517 421 dbSNP
rs1033458402 422 dbSNP
rs1263067480 424 dbSNP
rs531692944 425 dbSNP
rs1000193031 429 dbSNP
rs970004952 433 dbSNP
rs1471099473 435 dbSNP
rs1177939783 442 dbSNP
rs1023229949 451 dbSNP
rs1014484692 454 dbSNP
rs1465479231 455 dbSNP
rs1279755764 458 dbSNP
rs895990181 463 dbSNP
rs1015747233 466 dbSNP
rs561579481 467 dbSNP
rs1345727678 478 dbSNP
rs1220658072 480 dbSNP
rs1276947392 482 dbSNP
rs766876829 482 dbSNP
rs982992608 484 dbSNP
rs1047871838 485 dbSNP
rs1299981965 490 dbSNP
rs1192996360 491 dbSNP
rs1435919501 494 dbSNP
rs994351175 496 dbSNP
rs1027657933 511 dbSNP
rs896895217 515 dbSNP
rs543312323 516 dbSNP
rs941033561 519 dbSNP
rs1159604213 523 dbSNP
rs1362345603 527 dbSNP
rs910854545 528 dbSNP
rs1417839460 532 dbSNP
rs1297030603 534 dbSNP
rs527908125 534 dbSNP
rs1437995495 536 dbSNP
rs1272661686 538 dbSNP
rs1366493608 539 dbSNP
rs1224643237 544 dbSNP
rs1311965842 551 dbSNP
rs1352115528 559 dbSNP
rs1382044839 560 dbSNP
rs994489816 565 dbSNP
rs900190969 566 dbSNP
rs3169720 572 dbSNP
rs1008686595 579 dbSNP
rs1360735973 595 dbSNP
rs1481105297 598 dbSNP
rs1179000323 600 dbSNP
rs751894350 603 dbSNP
rs545569262 605 dbSNP
rs1042208342 606 dbSNP
rs1157909358 607 dbSNP
rs922453557 607 dbSNP
rs1385806047 612 dbSNP
rs1348903033 615 dbSNP
rs1406555364 615 dbSNP
rs988650162 618 dbSNP
rs377177156 632 dbSNP
rs1333767771 633 dbSNP
rs1428784439 634 dbSNP
rs956355954 637 dbSNP
rs1375230715 638 dbSNP
rs893700806 644 dbSNP
rs1054128162 647 dbSNP
rs1387923425 648 dbSNP
rs938006679 649 dbSNP
rs926643705 653 dbSNP
rs1438597712 654 dbSNP
rs979521220 655 dbSNP
rs536804421 656 dbSNP
rs982209429 660 dbSNP
rs1456238293 661 dbSNP
rs1177802478 662 dbSNP
rs949509556 665 dbSNP
rs1324341025 666 dbSNP
rs1160926423 667 dbSNP
rs908635058 667 dbSNP
rs1412514542 669 dbSNP
rs576906358 679 dbSNP
rs1465813423 681 dbSNP
rs1172286674 683 dbSNP
rs926059169 690 dbSNP
rs978804303 693 dbSNP
rs1449575915 696 dbSNP
rs1337849624 699 dbSNP
rs571411225 705 dbSNP
rs558226223 706 dbSNP
rs1340079923 710 dbSNP
rs1027221047 722 dbSNP
rs976100493 725 dbSNP
rs964402512 729 dbSNP
rs776096598 731 dbSNP
rs1317554312 733 dbSNP
rs1017729421 734 dbSNP
rs1014537212 742 dbSNP
rs1008572085 747 dbSNP
rs1484506479 750 dbSNP
rs527327773 751 dbSNP
rs1204250298 754 dbSNP
rs1026933494 758 dbSNP
rs1477828260 761 dbSNP
rs1195241022 763 dbSNP
rs762887268 766 dbSNP
rs1229365946 772 dbSNP
rs1464823982 773 dbSNP
rs773021175 779 dbSNP
rs1009377012 781 dbSNP
rs199695548 783 dbSNP
rs1413128923 788 dbSNP
rs1053695177 796 dbSNP
rs937958199 800 dbSNP
rs1401882301 803 dbSNP
rs762234503 804 dbSNP
rs905189237 804 dbSNP
rs1198527170 806 dbSNP
rs1275212310 806 dbSNP
rs755556498 806 dbSNP
rs1218139296 808 dbSNP
rs1277769177 808 dbSNP
rs1381250423 808 dbSNP
rs1046341245 810 dbSNP
rs1477289817 810 dbSNP
rs59928879 810 dbSNP
rs1303272860 811 dbSNP
rs111482977 812 dbSNP
rs1360050189 812 dbSNP
rs1491104383 812 dbSNP
rs949394281 814 dbSNP
rs1329584582 816 dbSNP
rs1368426545 816 dbSNP
rs908603930 816 dbSNP
rs982853548 817 dbSNP
rs1005231001 818 dbSNP
rs754891507 823 dbSNP
rs879160621 827 dbSNP
rs1209939090 829 dbSNP
rs149970908 829 dbSNP
rs3837836 829 dbSNP
rs58481905 829 dbSNP
rs1388808482 832 dbSNP
rs1367423760 840 dbSNP
rs554457992 848 dbSNP
rs1049368210 851 dbSNP
rs1377280678 852 dbSNP
rs1448738832 853 dbSNP
rs1162082613 855 dbSNP
rs1316305095 861 dbSNP
rs1244848471 864 dbSNP
rs1353800434 865 dbSNP
rs1208936742 866 dbSNP
rs920123251 872 dbSNP
rs933932979 880 dbSNP
rs1426133321 883 dbSNP
rs922539285 884 dbSNP
rs1415169850 888 dbSNP
rs1238058945 889 dbSNP
rs1053404713 893 dbSNP
rs1166973168 894 dbSNP
rs1182002272 902 dbSNP
rs1482298495 903 dbSNP
rs1457474857 905 dbSNP
rs1171582833 911 dbSNP
rs1402762662 915 dbSNP
rs1448673410 917 dbSNP
rs934517930 928 dbSNP
rs925746490 930 dbSNP
rs1206201912 931 dbSNP
rs775534610 934 dbSNP
rs534903450 935 dbSNP
rs1396591024 938 dbSNP
rs915941766 939 dbSNP
rs1314238886 943 dbSNP
rs1338121690 947 dbSNP
rs1232162982 948 dbSNP
rs369557079 951 dbSNP
rs765585314 956 dbSNP
rs1197106112 957 dbSNP
rs1257874615 960 dbSNP
rs987108405 962 dbSNP
rs1184039072 972 dbSNP
rs960607592 980 dbSNP
rs758918610 981 dbSNP
rs1426016534 984 dbSNP
rs1020695843 986 dbSNP
rs972692357 988 dbSNP
rs565653627 994 dbSNP
rs1353773051 1001 dbSNP
rs1466361660 1002 dbSNP
rs957887343 1005 dbSNP
rs1032628776 1012 dbSNP
rs1413583779 1018 dbSNP
rs548939952 1020 dbSNP
rs1341963694 1022 dbSNP
rs963592287 1029 dbSNP
rs1313352456 1032 dbSNP
rs1216475961 1038 dbSNP
rs1016364539 1039 dbSNP
rs1294413892 1040 dbSNP
rs372006844 1044 dbSNP
rs1212712069 1045 dbSNP
rs565939352 1047 dbSNP
rs770309861 1048 dbSNP
rs1410123249 1050 dbSNP
rs1389546729 1071 dbSNP
rs1013522090 1074 dbSNP
rs1476959325 1075 dbSNP
rs1291369109 1080 dbSNP
rs997862138 1081 dbSNP
rs900798109 1097 dbSNP
rs368250400 1117 dbSNP
rs920026337 1124 dbSNP
rs776222291 1125 dbSNP
rs538816508 1127 dbSNP
rs1434078716 1138 dbSNP
rs904379521 1139 dbSNP
rs1471886661 1142 dbSNP
rs761930872 1145 dbSNP
rs1287876834 1149 dbSNP
rs1042897646 1155 dbSNP
rs1183349141 1156 dbSNP
rs1221266957 1159 dbSNP
rs948816157 1160 dbSNP
rs151087663 1162 dbSNP
rs746671795 1165 dbSNP
rs1288783168 1169 dbSNP
rs993283010 1176 dbSNP
rs987072329 1201 dbSNP
rs1215180342 1203 dbSNP
rs938704521 1207 dbSNP
rs1489610918 1209 dbSNP
rs954346228 1219 dbSNP
rs913601877 1221 dbSNP
rs1159118732 1223 dbSNP
rs1382124140 1224 dbSNP
rs1417277812 1227 dbSNP
rs1157786546 1235 dbSNP
rs1265552149 1253 dbSNP
rs1350089350 1255 dbSNP
rs371691378 1259 dbSNP
rs1488860799 1266 dbSNP
rs972362476 1270 dbSNP
rs1292147022 1271 dbSNP
rs1370624056 1271 dbSNP
rs142928957 1276 dbSNP
rs1447996792 1280 dbSNP
rs12449732 1283 dbSNP
rs1312032635 1288 dbSNP
rs1260196776 1294 dbSNP
rs1223265376 1296 dbSNP
rs531757311 1297 dbSNP
rs1290743651 1298 dbSNP
rs567639156 1301 dbSNP
rs957986543 1307 dbSNP
rs566600577 1308 dbSNP
rs772908913 1310 dbSNP
rs1179056477 1313 dbSNP
rs1239900070 1317 dbSNP
rs1290041331 1321 dbSNP
rs1228789789 1322 dbSNP
rs986256538 1338 dbSNP
rs1298776553 1344 dbSNP
rs529254626 1345 dbSNP
rs1388104649 1352 dbSNP
rs71651947 1358 dbSNP
rs768987798 1360 dbSNP
rs953838436 1364 dbSNP
rs1024835425 1365 dbSNP
rs368843991 1366 dbSNP
rs887108639 1372 dbSNP
rs186897947 1373 dbSNP
rs1375302918 1374 dbSNP
rs1442193803 1382 dbSNP
rs1449441868 1390 dbSNP
rs1381344475 1395 dbSNP
rs1226704436 1397 dbSNP
rs1391456944 1405 dbSNP
rs1272736244 1406 dbSNP
rs1318920699 1407 dbSNP
rs1199013800 1410 dbSNP
rs1259814074 1413 dbSNP
rs900853121 1415 dbSNP
rs528010946 1419 dbSNP
rs560830882 1420 dbSNP
rs1201340668 1429 dbSNP
rs1185203875 1431 dbSNP
rs80038530 1439 dbSNP
rs140353172 1443 dbSNP
rs912761781 1446 dbSNP
rs1394871771 1447 dbSNP
rs948537343 1451 dbSNP
rs894280479 1453 dbSNP
rs1051338236 1455 dbSNP
rs946318942 1458 dbSNP
rs1057230062 1461 dbSNP
rs913487327 1462 dbSNP
rs1269944041 1463 dbSNP
rs1292798194 1464 dbSNP
rs1341343602 1467 dbSNP
rs147595057 1478 dbSNP
rs780499501 1480 dbSNP
rs1205602011 1491 dbSNP
rs1344058547 1493 dbSNP
rs988177675 1500 dbSNP
rs1208075679 1501 dbSNP
rs1256264269 1503 dbSNP
rs1254005342 1520 dbSNP
rs1477941758 1521 dbSNP
rs938742524 1522 dbSNP
rs1370997890 1524 dbSNP
rs1475268288 1524 dbSNP
rs1235014687 1529 dbSNP
rs919289060 1530 dbSNP
rs1312410440 1539 dbSNP
rs1427839105 1541 dbSNP
rs533314347 1542 dbSNP
rs1312344207 1549 dbSNP
rs1432280667 1560 dbSNP
rs543079106 1561 dbSNP
rs9910055 1573 dbSNP
rs969619676 1574 dbSNP
rs781326107 1575 dbSNP
rs953558452 1579 dbSNP
rs923408335 1580 dbSNP
rs761260024 1583 dbSNP
rs976549827 1585 dbSNP
rs1279529122 1588 dbSNP
rs965486668 1591 dbSNP
rs560575146 1592 dbSNP
rs541295042 1593 dbSNP
rs1446115882 1599 dbSNP
rs1248884615 1601 dbSNP
rs772422849 1601 dbSNP
rs1452964275 1602 dbSNP
rs1173495343 1605 dbSNP
rs1031368818 1611 dbSNP
rs1030017369 1622 dbSNP
rs1421552284 1629 dbSNP
rs1156945506 1630 dbSNP
rs1384502173 1634 dbSNP
rs1025531465 1635 dbSNP
rs1193876209 1637 dbSNP
rs1372826714 1650 dbSNP
rs1438459467 1664 dbSNP
rs1441740937 1664 dbSNP
rs995891788 1690 dbSNP
rs1241653623 1697 dbSNP
rs898521957 1697 dbSNP
rs998518735 1698 dbSNP
rs542590858 1702 dbSNP
rs879037954 1706 dbSNP
rs1273473577 1710 dbSNP
rs1225682730 1716 dbSNP
rs757337389 1717 dbSNP
rs1343710049 1719 dbSNP
rs1012811285 1720 dbSNP
rs1467379413 1725 dbSNP
rs1193441324 1727 dbSNP
rs1239292059 1730 dbSNP
rs1442140975 1731 dbSNP
rs183279698 1742 dbSNP
rs1363366689 1744 dbSNP
rs1244782588 1749 dbSNP
rs1057350823 1750 dbSNP
rs1392583942 1755 dbSNP
rs1459647431 1756 dbSNP
rs1336651924 1757 dbSNP
rs1396973391 1759 dbSNP
rs1377534093 1760 dbSNP
rs1002989154 1764 dbSNP
rs1393135487 1765 dbSNP
rs891299323 1766 dbSNP
rs1051227337 1784 dbSNP
rs553988004 1787 dbSNP
rs1274617101 1804 dbSNP
rs192552176 1810 dbSNP
rs764448429 1811 dbSNP
rs942040872 1814 dbSNP
rs758222505 1818 dbSNP
rs538466653 1819 dbSNP
rs1459481038 1822 dbSNP
rs909186115 1825 dbSNP
rs577735934 1835 dbSNP
rs1472462370 1839 dbSNP
rs1366662878 1840 dbSNP
rs73316181 1841 dbSNP
rs923490748 1843 dbSNP
rs1424422376 1845 dbSNP
rs936316715 1851 dbSNP
rs1485894381 1860 dbSNP
rs1475036467 1861 dbSNP
rs568543384 1871 dbSNP
rs1163937938 1872 dbSNP
rs1400671941 1877 dbSNP
rs1463341802 1882 dbSNP
rs1296328253 1886 dbSNP
rs1395717547 1889 dbSNP
rs367796281 1890 dbSNP
rs1396072323 1901 dbSNP
rs976647211 1905 dbSNP
rs1294653230 1906 dbSNP
rs925006019 1910 dbSNP
rs763232106 1915 dbSNP
rs1232376261 1919 dbSNP
rs1202635444 1930 dbSNP
rs1278447588 1932 dbSNP
rs1309574976 1933 dbSNP
rs965196672 1940 dbSNP
rs980926521 1952 dbSNP
rs947767773 1956 dbSNP
rs924357379 1964 dbSNP
rs991923436 1967 dbSNP
rs951233618 1974 dbSNP
rs1273166526 1975 dbSNP
rs1426074897 1980 dbSNP
rs1430037516 1992 dbSNP
rs1168102974 1993 dbSNP
rs1025961573 1995 dbSNP
rs977286809 1998 dbSNP
rs538371018 2005 dbSNP
rs144994852 2008 dbSNP
rs1413647337 2009 dbSNP
rs1286494646 2014 dbSNP
rs1007307287 2018 dbSNP
rs1208933335 2022 dbSNP
rs549441402 2022 dbSNP
rs891183297 2024 dbSNP
rs1029766068 2026 dbSNP
rs1010386030 2031 dbSNP
rs1237056082 2046 dbSNP
rs1012563082 2047 dbSNP
rs1278828145 2050 dbSNP
rs1347177561 2053 dbSNP
rs1217475813 2058 dbSNP
rs747118278 2061 dbSNP
rs891992371 2070 dbSNP
rs1350303925 2075 dbSNP
rs1035410107 2076 dbSNP
rs1003036797 2077 dbSNP
rs1433565555 2078 dbSNP
rs897610711 2093 dbSNP
rs1175375462 2097 dbSNP
rs1393220106 2099 dbSNP
rs368968434 2104 dbSNP
rs1433518023 2109 dbSNP
rs1411984776 2113 dbSNP
rs1371390377 2119 dbSNP
rs1428293077 2129 dbSNP
rs1036927504 2154 dbSNP
rs906110534 2157 dbSNP
rs118019638 2158 dbSNP
rs1403681994 2162 dbSNP
rs947735320 2175 dbSNP
rs1392919919 2177 dbSNP
rs759526399 2186 dbSNP
rs1164956562 2197 dbSNP
rs1475482465 2201 dbSNP
rs1056163286 2203 dbSNP
rs200146260 2203 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cgggcuggaguGGGUGGGGc 5'
                     |||||||| 
Target 5' -----------CCCACCCCa 3'
 		1 - 9
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM4903831
Method / RBP HITS-CLIP / AGO
Cell line / Condition Human neurons / 124TD_shELAVL3_a
Location of target site NM_014233 | 3UTR | CCCCUAUUUCCUUUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161238
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000343638.5 | 3UTR | CCCACCCCACCCACUUCUGCACUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
121 hsa-miR-4651 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066212 MARCH9 membrane associated ring-CH-type finger 9 2 2
MIRT113270 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 2
MIRT115795 CAPN15 calpain 15 2 2
MIRT125296 MID1IP1 MID1 interacting protein 1 2 2
MIRT145419 ANKRD13B ankyrin repeat domain 13B 2 2
MIRT153779 NCOA3 nuclear receptor coactivator 3 2 2
MIRT189384 TXLNA taxilin alpha 2 4
MIRT451063 PNMAL2 paraneoplastic Ma antigen family member 8B 2 2
MIRT451142 C19orf53 chromosome 19 open reading frame 53 2 2
MIRT452374 LY6E lymphocyte antigen 6 family member E 2 4
MIRT452788 FAM136A family with sequence similarity 136 member A 2 2
MIRT452985 CABP4 calcium binding protein 4 2 2
MIRT453231 FTSJ3 FtsJ RNA methyltransferase homolog 3 2 2
MIRT453824 SAA1 serum amyloid A1 2 2
MIRT454136 FOXRED2 FAD dependent oxidoreductase domain containing 2 2 2
MIRT455104 NKX2-2 NK2 homeobox 2 2 6
MIRT455250 DDX39B DExD-box helicase 39B 2 10
MIRT456899 DDA1 DET1 and DDB1 associated 1 2 2
MIRT457099 DCX doublecortin 2 2
MIRT457761 ZC3H12B zinc finger CCCH-type containing 12B 2 4
MIRT458539 CYP2B6 cytochrome P450 family 2 subfamily B member 6 2 2
MIRT459011 UQCRH ubiquinol-cytochrome c reductase hinge protein 2 2
MIRT459197 RCE1 Ras converting CAAX endopeptidase 1 2 2
MIRT459295 PHYKPL 5-phosphohydroxy-L-lysine phospho-lyase 2 2
MIRT459466 MUC17 mucin 17, cell surface associated 2 4
MIRT459598 KCNK3 potassium two pore domain channel subfamily K member 3 2 2
MIRT461274 COX10 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 2 2
MIRT464551 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT465253 TRIM44 tripartite motif containing 44 2 2
MIRT465274 TRIM28 tripartite motif containing 28 2 2
MIRT465402 TP53 tumor protein p53 2 2
MIRT465877 TMEM43 transmembrane protein 43 2 4
MIRT466234 TMED10 transmembrane p24 trafficking protein 10 2 2
MIRT467027 SRSF1 serine and arginine rich splicing factor 1 2 4
MIRT468320 SF3B3 splicing factor 3b subunit 3 2 2
MIRT468437 SETD1B SET domain containing 1B 2 2
MIRT468691 SEC22C SEC22 homolog C, vesicle trafficking protein 2 4
MIRT468863 RREB1 ras responsive element binding protein 1 2 2
MIRT469779 RAB15 RAB15, member RAS oncogene family 2 2
MIRT470314 PPP6R1 protein phosphatase 6 regulatory subunit 1 2 2
MIRT470765 PNPLA6 patatin like phospholipase domain containing 6 2 2
MIRT472213 NGFR nerve growth factor receptor 2 2
MIRT472520 NACC1 nucleus accumbens associated 1 2 2
MIRT473281 MFRP membrane frizzled-related protein 2 2
MIRT473403 MDM4 MDM4, p53 regulator 2 2
MIRT473521 MAX MYC associated factor X 2 2
MIRT474529 KLHDC8A kelch domain containing 8A 2 2
MIRT474631 KLF16 Kruppel like factor 16 2 2
MIRT475130 IP6K1 inositol hexakisphosphate kinase 1 2 2
MIRT475808 HDGF heparin binding growth factor 2 2
MIRT478623 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT479501 CDH6 cadherin 6 2 2
MIRT479865 CCDC6 coiled-coil domain containing 6 2 2
MIRT480132 CALR calreticulin 2 2
MIRT480529 C10orf76 chromosome 10 open reading frame 76 2 2
MIRT480774 BMP2 bone morphogenetic protein 2 2 2
MIRT481423 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT481778 APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 2 2
MIRT481821 AP2M1 adaptor related protein complex 2 mu 1 subunit 2 2
MIRT482698 XRCC3 X-ray repair cross complementing 3 2 2
MIRT482976 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT483391 SPATA6 spermatogenesis associated 6 2 4
MIRT483429 RHOXF2B Rhox homeobox family member 2B 2 2
MIRT483476 STMN3 stathmin 3 2 4
MIRT483687 CYP11A1 cytochrome P450 family 11 subfamily A member 1 2 2
MIRT483803 CYP2W1 cytochrome P450 family 2 subfamily W member 1 2 6
MIRT484335 EPN1 epsin 1 2 4
MIRT484683 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT484966 UCK1 uridine-cytidine kinase 1 2 2
MIRT485987 YIPF2 Yip1 domain family member 2 2 2
MIRT486773 SESTD1 SEC14 and spectrin domain containing 1 2 4
MIRT487372 C10orf54 V-set immunoregulatory receptor 2 2
MIRT487632 ONECUT3 one cut homeobox 3 2 4
MIRT488080 DLGAP3 DLG associated protein 3 2 4
MIRT488158 PRRC2B proline rich coiled-coil 2B 2 4
MIRT488463 B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 2 2
MIRT490948 PPM1F protein phosphatase, Mg2+/Mn2+ dependent 1F 2 2
MIRT491719 RTN4R reticulon 4 receptor 2 2
MIRT492338 SEPT8 septin 8 2 2
MIRT493038 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT493368 KIAA1614 KIAA1614 2 2
MIRT499384 PLCG2 phospholipase C gamma 2 2 11
MIRT499596 ANKRD45 ankyrin repeat domain 45 2 2
MIRT499730 USH1G USH1 protein network component sans 2 4
MIRT500357 ZNF385A zinc finger protein 385A 2 2
MIRT501691 PCGF3 polycomb group ring finger 3 2 6
MIRT504502 PPP1R9B protein phosphatase 1 regulatory subunit 9B 2 2
MIRT509579 HIST2H2AB histone cluster 2 H2A family member b 2 4
MIRT510610 TPM3 tropomyosin 3 2 2
MIRT512803 GLRX glutaredoxin 2 2
MIRT513302 SETBP1 SET binding protein 1 2 2
MIRT514005 CECR2 CECR2, histone acetyl-lysine reader 2 4
MIRT515701 ZNF321P zinc finger protein 321, pseudogene 2 2
MIRT518260 LEAP2 liver enriched antimicrobial peptide 2 2 2
MIRT523183 HIST3H3 histone cluster 3 H3 2 2
MIRT524051 DNAJC8 DnaJ heat shock protein family (Hsp40) member C8 2 2
MIRT538642 CCSAP centriole, cilia and spindle associated protein 2 2
MIRT541497 ADM adrenomedullin 2 2
MIRT569279 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT570279 ARPC3 actin related protein 2/3 complex subunit 3 2 2
MIRT570326 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT571451 YKT6 YKT6 v-SNARE homolog 2 2
MIRT571597 TOB2 transducer of ERBB2, 2 2 2
MIRT574894 Plcg2 phospholipase C, gamma 2 2 7
MIRT607551 GLI2 GLI family zinc finger 2 2 2
MIRT607694 MAPK10 mitogen-activated protein kinase 10 2 2
MIRT609983 PPARA peroxisome proliferator activated receptor alpha 2 2
MIRT610076 CRLF1 cytokine receptor like factor 1 2 2
MIRT610578 CACUL1 CDK2 associated cullin domain 1 2 4
MIRT626322 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT634011 RIF1 replication timing regulatory factor 1 2 2
MIRT642680 KRT74 keratin 74 2 2
MIRT689717 ATXN2 ataxin 2 2 2
MIRT691175 APOL6 apolipoprotein L6 2 2
MIRT693169 NPR1 natriuretic peptide receptor 1 2 2
MIRT697121 OTUD5 OTU deubiquitinase 5 2 2
MIRT711817 ELN elastin 2 2
MIRT721551 FXN frataxin 2 2
MIRT721666 SLFN12 schlafen family member 12 2 2
MIRT723760 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 2
MIRT737362 FOXP4 forkhead box P4 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4651 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4651 Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-4651 Cisplatin 5460033 NSC119875 approved resistant High Pancreatic Cancer cell line (BxPC-3)
hsa-miR-4651 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4651 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4651 Curcumin 969516 NSC32982 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4651 Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4651 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4651 Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-mir-4651 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4651 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4651 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4651 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (cytosolic RNA)
hsa-miR-4651 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (total RNA)
hsa-miR-4651 Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-4651 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-4651 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-4651 Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-4651 Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-miR-4651 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4651 Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-4651 Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-4651 Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-4651 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4651 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-4651 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

Error report submission