miRTarBase - #MIRT464952


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pre-miRNA Information
pre-miRNA hsa-mir-4316   
Genomic Coordinates chr17: 77396984 - 77397054
Description Homo sapiens miR-4316 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4316
Sequence 11| GGUGAGGCUAGCUGGUG |27
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs989002279 5 dbSNP
rs957742923 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TWIST1   
Synonyms ACS3, BPES2, BPES3, CRS, CRS1, CSO, SCS, TWIST, bHLHa38
Description twist family bHLH transcription factor 1
Transcript NM_000474   
Expression
Putative miRNA Targets on TWIST1
3'UTR of TWIST1
(miRNA target sites are highlighted)		 
>TWIST1|NM_000474|3'UTR
   1 CAGGCGGAGCCCCCCACCCCCTCAGCAGGGCCGGAGACCTAGATGTCATTGTTTCCAGAGAAGGAGAAAATGGACAGTCT
  81 AGAGACTCTGGAGCTGGATAACTAAAAATAAAAATATATGCCAAAGATTTTCTTGGAAATTAGAAGAGCAAAATCCAAAT
 161 TCAAAGAAACAGGGCGTGGGGCGCACTTTTAAAAGAGAAAGCGAGACAGGCCCGTGGACAGTGATTCCCAGACGGGCAGC
 241 GGCACCATCCTCACACCTCTGCATTCTGATAGAAGTCTGAACAGTTGTTTGTGTTTTTTTTTTTTTTTTTTTTGACGAAG
 321 AATGTTTTTATTTTTATTTTTTTCATGCATGCATTCTCAAGAGGTCGTGCCAATCAGCCACTGAAAGGAAAGGCATCACT
 401 ATGGACTTTCTCTATTTTAAAATGGTAACAATCAGAGGAACTATAAGAACACCTTTAGAAATAAAAATACTGGGATCAAA
 481 CTGGCCTGCAAAACCATAGTCAGTTAATTCTTTTTTTCATCCTTCCTCTGAGGGGAAAAACAAAAAAAAACTTAAAATAC
 561 AAAAAACAACATTCTATTTATTTATTGAGGACCCATGGTAAAATGCAAATAGATCCGGTGTCTAAATGCATTCATATTTT
 641 TATGATTGTTTTGTAAATATCTTTGTATATTTTTCTGCAATAAATAAATATAAAAAATTTAGAGAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' guggucgaucGGAGUGg 5'
                    |||||| 
Target 5' gcggcaccatCCTCACa 3'
 239 - 255 120.00 -14.90
2 
miRNA  3' guggucgaUCGGAGUGg 5'
                  :|| |||| 
Target 5' aaaggaaaGGCATCACt 3'
 384 - 400 109.00 -5.70
3 
miRNA  3' guGGUCGAUCGGA-GUgg 5'
            | | ||:|||| ||  
Target 5' atCAAACTGGCCTGCAaa 3'
 475 - 492 103.00 -10.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN24295366 1 COSMIC
COSN30128221 9 COSMIC
COSN5098878 9 COSMIC
COSN30699045 10 COSMIC
COSN30753275 25 COSMIC
COSN8789486 53 COSMIC
COSN29297538 96 COSMIC
COSN24951752 150 COSMIC
COSN16777545 156 COSMIC
COSN20726843 198 COSMIC
COSN20758808 374 COSMIC
COSN27362502 489 COSMIC
COSN27339322 555 COSMIC
COSN29462858 567 COSMIC
COSN30543232 586 COSMIC
COSN22674195 665 COSMIC
COSN31571193 671 COSMIC
COSN22118780 690 COSMIC
COSN22120337 693 COSMIC
COSN31521778 718 COSMIC
COSN31547883 731 COSMIC
COSN31562200 744 COSMIC
COSN31578895 771 COSMIC
COSN26556864 784 COSMIC
COSN26639403 793 COSMIC
COSN26644651 832 COSMIC
COSN20103808 833 COSMIC
COSN20103809 833 COSMIC
COSN31515118 836 COSMIC
COSN19659100 869 COSMIC
COSN20091529 875 COSMIC
COSN31480109 911 COSMIC
COSN7973356 977 COSMIC
COSN31556401 1080 COSMIC
COSN2214396 1120 COSMIC
COSN26574783 1182 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs775715586 2 dbSNP
rs1353667669 5 dbSNP
rs769923744 6 dbSNP
rs1420542078 9 dbSNP
rs1362688958 10 dbSNP
rs760470134 11 dbSNP
rs772911763 12 dbSNP
rs1369591313 14 dbSNP
rs1167571388 15 dbSNP
rs778566992 16 dbSNP
rs558318692 19 dbSNP
rs1256214065 20 dbSNP
rs778388839 21 dbSNP
rs1461053563 22 dbSNP
rs754536695 22 dbSNP
rs1260558809 23 dbSNP
rs537671443 25 dbSNP
rs1198488863 28 dbSNP
rs748757824 30 dbSNP
rs372109750 32 dbSNP
rs867793755 35 dbSNP
rs750764487 39 dbSNP
rs781725395 41 dbSNP
rs753401350 44 dbSNP
rs757830026 47 dbSNP
rs1342668686 50 dbSNP
rs1316455299 51 dbSNP
rs879910149 53 dbSNP
rs1192453490 54 dbSNP
rs1421403912 55 dbSNP
rs1404092693 56 dbSNP
rs930088700 59 dbSNP
rs922658342 63 dbSNP
rs1170805426 65 dbSNP
rs953062129 66 dbSNP
rs1310641433 69 dbSNP
rs1301455464 70 dbSNP
rs1404879838 83 dbSNP
rs1433742855 91 dbSNP
rs1396990825 93 dbSNP
rs975957113 95 dbSNP
rs1318173969 96 dbSNP
rs944506655 97 dbSNP
rs1339137126 101 dbSNP
rs1220491183 108 dbSNP
rs1360564603 111 dbSNP
rs1029109387 112 dbSNP
rs1231418309 113 dbSNP
rs1257526072 114 dbSNP
rs548746046 115 dbSNP
rs1159902495 117 dbSNP
rs1489259606 120 dbSNP
rs986005553 121 dbSNP
rs967953537 122 dbSNP
rs1022003146 123 dbSNP
rs987788958 132 dbSNP
rs368929258 133 dbSNP
rs1425852627 134 dbSNP
rs377293398 139 dbSNP
rs536574277 143 dbSNP
rs188412313 144 dbSNP
rs547854422 145 dbSNP
rs866021895 146 dbSNP
rs1488757105 149 dbSNP
rs1402438211 152 dbSNP
rs906753301 156 dbSNP
rs1288474127 161 dbSNP
rs1345024739 167 dbSNP
rs1385170980 171 dbSNP
rs1303593562 175 dbSNP
rs1025205148 176 dbSNP
rs1237995053 177 dbSNP
rs1283673671 181 dbSNP
rs1355764225 181 dbSNP
rs1217324922 183 dbSNP
rs1214525747 185 dbSNP
rs1487182960 185 dbSNP
rs1350133748 186 dbSNP
rs4647960 187 dbSNP
rs1023805028 188 dbSNP
rs1418195648 189 dbSNP
rs1005793813 191 dbSNP
rs766889703 192 dbSNP
rs1422042960 193 dbSNP
rs888686473 194 dbSNP
rs183006608 196 dbSNP
rs895146986 197 dbSNP
rs1047074271 198 dbSNP
rs929952920 200 dbSNP
rs1053791756 201 dbSNP
rs901268371 202 dbSNP
rs1306792518 204 dbSNP
rs1413986974 206 dbSNP
rs1240612134 211 dbSNP
rs1290901436 217 dbSNP
rs1041490949 218 dbSNP
rs944558550 219 dbSNP
rs1223103341 227 dbSNP
rs1265554300 231 dbSNP
rs910416667 232 dbSNP
rs1340723504 233 dbSNP
rs902616235 235 dbSNP
rs985953114 236 dbSNP
rs1299715479 240 dbSNP
rs946644286 245 dbSNP
rs1422632330 250 dbSNP
rs915140232 272 dbSNP
rs911744387 273 dbSNP
rs987819993 274 dbSNP
rs780927923 275 dbSNP
rs956540614 279 dbSNP
rs1283436082 287 dbSNP
rs565381752 292 dbSNP
rs1230023593 294 dbSNP
rs549979233 296 dbSNP
rs1306350969 298 dbSNP
rs973048897 307 dbSNP
rs969160188 311 dbSNP
rs1265607363 314 dbSNP
rs147172672 322 dbSNP
rs1005656103 332 dbSNP
rs983187688 341 dbSNP
rs60767072 348 dbSNP
rs542003035 351 dbSNP
rs532302907 352 dbSNP
rs994187014 356 dbSNP
rs1168655415 357 dbSNP
rs901129685 359 dbSNP
rs1466376183 361 dbSNP
rs1012462335 364 dbSNP
rs1336819939 365 dbSNP
rs754626503 369 dbSNP
rs1303287373 371 dbSNP
rs1271251860 375 dbSNP
rs1339794999 376 dbSNP
rs1216198067 377 dbSNP
rs1279593718 379 dbSNP
rs1318129176 387 dbSNP
rs1222587635 388 dbSNP
rs1041049683 389 dbSNP
rs1232440004 398 dbSNP
rs1276085476 399 dbSNP
rs942812537 402 dbSNP
rs1310741493 403 dbSNP
rs1318414103 407 dbSNP
rs889863473 410 dbSNP
rs1050269625 414 dbSNP
rs1488279861 415 dbSNP
rs946505244 416 dbSNP
rs574432712 417 dbSNP
rs559181197 424 dbSNP
rs1052312687 425 dbSNP
rs1000888985 430 dbSNP
rs935262098 431 dbSNP
rs1478262110 437 dbSNP
rs746505972 438 dbSNP
rs1423326433 459 dbSNP
rs927656258 471 dbSNP
rs540624266 473 dbSNP
rs1323680456 477 dbSNP
rs1398112842 482 dbSNP
rs1299485869 485 dbSNP
rs1340536815 487 dbSNP
rs1435135612 488 dbSNP
rs969569027 488 dbSNP
rs1008764514 495 dbSNP
rs1346715155 499 dbSNP
rs1164916939 501 dbSNP
rs576400040 503 dbSNP
rs984265477 505 dbSNP
rs1288797267 507 dbSNP
rs1488617504 511 dbSNP
rs952846048 513 dbSNP
rs931881638 514 dbSNP
rs1025852368 518 dbSNP
rs1245151952 519 dbSNP
rs1479157032 526 dbSNP
rs1191522518 530 dbSNP
rs1379528069 532 dbSNP
rs1417647887 535 dbSNP
rs1426253162 536 dbSNP
rs1160318991 544 dbSNP
rs779489948 545 dbSNP
rs921863109 549 dbSNP
rs994865345 550 dbSNP
rs558633197 551 dbSNP
rs879267780 552 dbSNP
rs1436841469 554 dbSNP
rs149963436 555 dbSNP
rs865781232 555 dbSNP
rs1238430621 556 dbSNP
rs965649550 557 dbSNP
rs1020060701 558 dbSNP
rs1006873350 559 dbSNP
rs918059274 560 dbSNP
rs889888623 561 dbSNP
rs773982572 562 dbSNP
rs1010747489 563 dbSNP
rs893684143 564 dbSNP
rs891210996 565 dbSNP
rs1234011754 566 dbSNP
rs1251059409 567 dbSNP
rs138390369 567 dbSNP
rs1487208910 567 dbSNP
rs539560603 567 dbSNP
rs55734353 567 dbSNP
rs575838997 567 dbSNP
rs745507465 567 dbSNP
rs779739552 567 dbSNP
rs536778035 568 dbSNP
rs555500155 568 dbSNP
rs1235848494 569 dbSNP
rs1491577140 569 dbSNP
rs1420991129 570 dbSNP
rs1491350542 570 dbSNP
rs1325752688 572 dbSNP
rs1052261862 574 dbSNP
rs527926420 578 dbSNP
rs1051574370 581 dbSNP
rs1397730078 582 dbSNP
rs758406720 590 dbSNP
rs576068002 594 dbSNP
rs1395814538 595 dbSNP
rs1332727728 596 dbSNP
rs1342807910 600 dbSNP
rs1415454013 602 dbSNP
rs996430400 603 dbSNP
rs900367607 605 dbSNP
rs1220760007 612 dbSNP
rs1252126555 618 dbSNP
rs554912927 621 dbSNP
rs935276017 623 dbSNP
rs1343943991 634 dbSNP
rs1198543467 642 dbSNP
rs1037568067 646 dbSNP
rs1402864576 655 dbSNP
rs941985232 661 dbSNP
rs1327238555 663 dbSNP
rs1409804260 672 dbSNP
rs907510572 674 dbSNP
rs1426122843 675 dbSNP
rs1174599054 677 dbSNP
rs536833438 682 dbSNP
rs566389049 687 dbSNP
rs927886096 703 dbSNP
rs1452583812 706 dbSNP
rs1046504226 708 dbSNP
rs781606517 709 dbSNP
rs1192872094 711 dbSNP
rs947716028 713 dbSNP
rs1404943139 721 dbSNP
rs1458182818 722 dbSNP
rs1297646495 724 dbSNP
rs1338452566 729 dbSNP
rs1234571210 730 dbSNP
rs1296510480 734 dbSNP
rs1202152363 742 dbSNP
rs1330762809 747 dbSNP
rs949136788 751 dbSNP
rs1437074399 752 dbSNP
rs916336438 753 dbSNP
rs1215877949 756 dbSNP
rs750393195 758 dbSNP
rs1283814748 764 dbSNP
rs1488962444 768 dbSNP
rs1186618474 770 dbSNP
rs983794184 772 dbSNP
rs1266205668 773 dbSNP
rs1431136202 775 dbSNP
rs548062966 778 dbSNP
rs868514139 780 dbSNP
rs972911369 784 dbSNP
rs966037847 791 dbSNP
rs1158504251 804 dbSNP
rs35259071 805 dbSNP
rs1019836345 809 dbSNP
rs925477895 814 dbSNP
rs1289568230 821 dbSNP
rs1240295694 826 dbSNP
rs1390246375 828 dbSNP
rs979679683 829 dbSNP
rs1376144430 830 dbSNP
rs201649810 832 dbSNP
rs1007312209 833 dbSNP
rs1306927667 833 dbSNP
rs1371386714 833 dbSNP
rs866855015 834 dbSNP
rs1215847939 835 dbSNP
rs987217260 836 dbSNP
rs955459197 837 dbSNP
rs1211208107 838 dbSNP
rs1028808667 839 dbSNP
rs996969201 840 dbSNP
rs1433113440 841 dbSNP
rs1374885697 851 dbSNP
rs1159917050 853 dbSNP
rs1379022529 853 dbSNP
rs1421437472 853 dbSNP
rs1491286759 853 dbSNP
rs201604997 853 dbSNP
rs34284409 853 dbSNP
rs763575517 853 dbSNP
rs764306112 853 dbSNP
rs796641991 853 dbSNP
rs878961789 853 dbSNP
rs1311943977 854 dbSNP
rs1491195633 854 dbSNP
rs1319337295 855 dbSNP
rs1246393742 858 dbSNP
rs1273367476 859 dbSNP
rs111902598 861 dbSNP
rs1159296444 863 dbSNP
rs377447559 864 dbSNP
rs1481897905 866 dbSNP
rs373862489 869 dbSNP
rs1422090570 870 dbSNP
rs1016089458 875 dbSNP
rs1056312759 875 dbSNP
rs1168258904 881 dbSNP
rs1356004363 883 dbSNP
rs1442672295 883 dbSNP
rs1175417612 884 dbSNP
rs571517784 885 dbSNP
rs886371867 886 dbSNP
rs1189577655 888 dbSNP
rs550134072 891 dbSNP
rs866140111 893 dbSNP
rs1216474644 896 dbSNP
rs1259605695 904 dbSNP
rs562154901 906 dbSNP
rs577286074 911 dbSNP
rs1237390354 913 dbSNP
rs1482586295 929 dbSNP
rs1190150571 933 dbSNP
rs1216692574 937 dbSNP
rs1258391443 938 dbSNP
rs1318273117 940 dbSNP
rs561424240 944 dbSNP
rs1191696790 951 dbSNP
rs1421960350 953 dbSNP
rs1282685639 967 dbSNP
rs1223725847 970 dbSNP
rs548092290 973 dbSNP
rs1380280888 974 dbSNP
rs896184828 977 dbSNP
rs891874623 979 dbSNP
rs1031277837 982 dbSNP
rs778096967 982 dbSNP
rs1355035020 983 dbSNP
rs1397593370 985 dbSNP
rs1299092231 991 dbSNP
rs925404214 992 dbSNP
rs12669895 997 dbSNP
rs1362252551 1007 dbSNP
rs979602706 1009 dbSNP
rs999344232 1010 dbSNP
rs945579830 1023 dbSNP
rs757143259 1024 dbSNP
rs1310945187 1033 dbSNP
rs914155164 1035 dbSNP
rs1281675392 1038 dbSNP
rs987093520 1041 dbSNP
rs1191629925 1044 dbSNP
rs955542698 1049 dbSNP
rs529792015 1064 dbSNP
rs753969715 1071 dbSNP
rs1422869115 1073 dbSNP
rs1156781948 1080 dbSNP
rs906454126 1089 dbSNP
rs1359856115 1090 dbSNP
rs1400076180 1090 dbSNP
rs559241074 1090 dbSNP
rs1345415160 1096 dbSNP
rs1435388179 1099 dbSNP
rs1046275373 1100 dbSNP
rs947723913 1108 dbSNP
rs1369153536 1110 dbSNP
rs1189776888 1114 dbSNP
rs1205556810 1115 dbSNP
rs962776774 1124 dbSNP
rs1304750415 1126 dbSNP
rs1353688163 1129 dbSNP
rs1203429122 1135 dbSNP
rs1474139103 1137 dbSNP
rs894851897 1143 dbSNP
rs563616060 1147 dbSNP
rs1048040978 1148 dbSNP
rs1006029158 1154 dbSNP
rs1221032864 1155 dbSNP
rs931093715 1156 dbSNP
rs1486526515 1157 dbSNP
rs1469616061 1158 dbSNP
rs1194050521 1172 dbSNP
rs918315989 1173 dbSNP
rs973329246 1176 dbSNP
rs1159781978 1181 dbSNP
rs1408004750 1183 dbSNP
rs944186464 1199 dbSNP
rs1239881306 1200 dbSNP
rs1396256010 1204 dbSNP
rs912810065 1206 dbSNP
rs985770191 1207 dbSNP
rs1327047624 1224 dbSNP
rs1215646873 1230 dbSNP
rs868509997 1232 dbSNP
rs1237596458 1237 dbSNP
rs1281791888 1239 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' guggucgaucGGAGUGg 5'
                    |||||| 
Target 5' ----caccauCCUCACa 3'
 		1 - 13
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000242261.5 | 3UTR | CACCAUCCUCACACCUCUGCAUUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
74 hsa-miR-4316 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT080624 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2 2
MIRT095088 SEC24A SEC24 homolog A, COPII coat complex component 2 4
MIRT123331 CALU calumenin 2 2
MIRT154964 RRM2 ribonucleotide reductase regulatory subunit M2 2 2
MIRT370850 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT442955 SGCD sarcoglycan delta 2 2
MIRT448240 ZNF774 zinc finger protein 774 2 2
MIRT451710 OLR1 oxidized low density lipoprotein receptor 1 2 2
MIRT452072 ATP6V0B ATPase H+ transporting V0 subunit b 2 2
MIRT455665 GLO1 glyoxalase I 2 2
MIRT460354 TXNDC16 thioredoxin domain containing 16 2 2
MIRT461908 NECAB3 N-terminal EF-hand calcium binding protein 3 2 2
MIRT462047 HOXC13 homeobox C13 2 2
MIRT462735 EFNB1 ephrin B1 2 2
MIRT463409 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT464952 TWIST1 twist family bHLH transcription factor 1 2 2
MIRT465052 TSR1 TSR1, ribosome maturation factor 2 2
MIRT467549 SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 2 4
MIRT470226 PRRC2A proline rich coiled-coil 2A 2 2
MIRT474081 LMBR1L limb development membrane protein 1 like 2 2
MIRT474481 KLHDC8B kelch domain containing 8B 2 2
MIRT474704 KIF3A kinesin family member 3A 2 2
MIRT474897 KCTD21 potassium channel tetramerization domain containing 21 2 2
MIRT475203 IL2RB interleukin 2 receptor subunit beta 2 2
MIRT477664 EFHD2 EF-hand domain family member D2 2 2
MIRT477775 E2F3 E2F transcription factor 3 2 2
MIRT477940 DPM2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory 2 2
MIRT478224 DDX52 DExD-box helicase 52 2 2
MIRT479904 CCDC117 coiled-coil domain containing 117 2 2
MIRT480639 BSCL2 BSCL2, seipin lipid droplet biogenesis associated 2 2
MIRT482435 ADM adrenomedullin 2 10
MIRT483908 GNB1L G protein subunit beta 1 like 2 2
MIRT484161 FAM71B family with sequence similarity 71 member B 2 2
MIRT484405 SNX19 sorting nexin 19 2 2
MIRT485426 LASP1 LIM and SH3 protein 1 2 2
MIRT489788 KRT80 keratin 80 2 4
MIRT490813 ASB1 ankyrin repeat and SOCS box containing 1 2 4
MIRT491176 LAMA5 laminin subunit alpha 5 2 2
MIRT491573 HSDL1 hydroxysteroid dehydrogenase like 1 2 2
MIRT492633 PLXNA1 plexin A1 2 2
MIRT492984 NAV1 neuron navigator 1 2 2
MIRT496441 RAB11FIP4 RAB11 family interacting protein 4 2 2
MIRT501829 NCOA3 nuclear receptor coactivator 3 2 2
MIRT502165 KIAA0195 transmembrane protein 94 2 2
MIRT508652 DIABLO diablo IAP-binding mitochondrial protein 2 4
MIRT509554 ACTG1 actin gamma 1 2 4
MIRT520033 YOD1 YOD1 deubiquitinase 2 6
MIRT523969 DVL3 dishevelled segment polarity protein 3 2 2
MIRT526150 KIAA1456 KIAA1456 2 2
MIRT530330 ARHGAP1 Rho GTPase activating protein 1 2 2
MIRT539985 SLC24A4 solute carrier family 24 member 4 2 4
MIRT540851 NUP155 nucleoporin 155 2 2
MIRT542326 LIMD1 LIM domains containing 1 2 2
MIRT558908 CBX5 chromobox 5 2 2
MIRT563663 SMC4 structural maintenance of chromosomes 4 2 2
MIRT565433 SURF4 surfeit 4 2 2
MIRT567773 DGAT2 diacylglycerol O-acyltransferase 2 2 2
MIRT615573 NCS1 neuronal calcium sensor 1 2 2
MIRT627336 TTLL7 tubulin tyrosine ligase like 7 2 2
MIRT632965 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT634307 SNTN sentan, cilia apical structure protein 2 2
MIRT641569 RAX retina and anterior neural fold homeobox 2 2
MIRT660509 ARL5A ADP ribosylation factor like GTPase 5A 2 2
MIRT662703 C10orf111 chromosome 10 open reading frame 111 2 4
MIRT663214 ZNF277 zinc finger protein 277 2 2
MIRT665318 YIPF4 Yip1 domain family member 4 2 2
MIRT695264 CD209 CD209 molecule 2 2
MIRT696231 LIN9 lin-9 DREAM MuvB core complex component 2 2
MIRT698867 SRPR SRP receptor alpha subunit 2 2
MIRT702700 IPO9 importin 9 2 2
MIRT704236 DHDDS dehydrodolichyl diphosphate synthase subunit 2 2
MIRT704935 CCDC120 coiled-coil domain containing 120 2 2
MIRT724285 KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 2 2
MIRT735579 VEGFA vascular endothelial growth factor A 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4316 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-miR-4316 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4316 Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

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