miRTarBase - #MIRT465065


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pre-miRNA Information
pre-miRNA hsa-mir-1208   
Genomic Coordinates chr8: 128150116 - 128150188
Synonyms MIRN1208, hsa-mir-1208, MIR1208
Description Homo sapiens miR-1208 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-1208
Sequence 12| UCACUGUUCAGACAGGCGGA |31
Evidence Experimental
Experiments Northern
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs756433811 2 dbSNP
rs780440181 3 dbSNP
rs1380328961 4 dbSNP
rs747737307 8 dbSNP
rs771811651 10 dbSNP
rs1350004170 13 dbSNP
rs375652780 17 dbSNP
rs552306924 18 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TSR1   
Synonyms -
Description TSR1, ribosome maturation factor
Transcript NM_018128   
Expression
Putative miRNA Targets on TSR1
3'UTR of TSR1
(miRNA target sites are highlighted)		 
>TSR1|NM_018128|3'UTR
   1 TGGATTCAAAGAGATTCTGTCTTACCGGTGCCAGTCAGTACTCCAGGGATGGGAGGCACAAGTTGTGATTGGGCAAAGTT
  81 TATTTTCTATGTCAGCCTGTCAGTCCACTGCCCCATTTTGCAAGACTTTTTTTTAGCCTTGACAAAATGTCTCAGTTAAG
 161 TATAAAAGTTTTTCCACTACTTAGTCCAAAAAAAACTATTAAATCTTAATGAAATAGCCACTCTCCATTAAGAATCTGAT
 241 AACTAAGAGTTGACAATACTAGGAAACAAAATGTCTTCAGTATCTAAAGACACTGAATTCCCACCATTTCCTTTTCTGTA
 321 AATTAAACAGAAACAGACTGATAAGAAGCTGGCCTTTCAGCCTGCTTCACCCAAGTTATGGAGGAGGTTAAGTCTACATT
 401 TCCACCACTGAGCACAATACAAATGTTCTTTACTTCTGGGGAAACAGTTTGAAAATGTTGAGACAGCACAGCAGCCACTC
 481 CAACACCAGCTGTAGGTTCAATGAGTAGTTTCATCCTCTCCCACACCAGCTGGGTTGCACACTGTTGATATGGAAGGGAG
 561 TAGGAATTAGTGAAAGGGGAGTCTAGTTGGTTTACCTATAAAGTTCAGATGAGAATACGTGTCCAGTTTGAATTTTCTTA
 641 TCACTGTGTACACACGCTTCCCAAAGCTTTTCTTTAATTCTGACTCTGCTTCTGTCAAGAGGGTTGTCATTAATACATCT
 721 AGGGTACCCTCCCATGTCATGAAGTTACCTAGTCAGGTTCCCGTGGGTCACTTGCTACTCCTAAGGGAAGTTTCTTCTGC
 801 CTAAGAAGTTACACCATGCTTTGCTATTTCTTTTCTTGCTGGAGCCTCACCTTAATTTCATCCTCTGTGACAGTGAAGAT
 881 ATCATCCACAAGGTCCCTGATAATAGGCCAGGTGTTCAAGCCAATGCTGGATTTGACACCATCTGCTATGGTTTCTGGAG
 961 GATAAAGATTGGGCATCAGTTTCCCCTTCAGCTTGGACTGGTAGCAGTCATCTGCATTTGAGGGTTCAGCAGCATATACC
1041 TTCACACTAGGTTTCAGAGCCTGGGAAGAGGAATATTAAGACATCTTAACAACAAACCACAACATTGCCTGCATGTCTAA
1121 AAGAAAATATGGGCCTGGTGTGGTGGCTCACACCTGTAATCCCAACACTTTGGGAGCCCGAGGCGGGTGGATCAGCTGAG
1201 GTCAGGAGTTCAAGACCAGCCTGGCCAACCTGGTGAAATGCAGTGTCAACTAAAAATAGGAAAATCAGCCAGGCGTGGTG
1281 GCAGACCCCTGTAATCCCAGCTACTCAAGAGGCTGAGGTAGGAGAATCACTTGAACTTGGGAGGGGTAGGTTGCAGTGAG
1361 CTGAGATCACACCAAAATGGGGTGGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGA
1441 TCACGAGGTAGGGAGATCAAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aggcggacAGAC-UUGUCACu 5'
                  |||| :|||||| 
Target 5' tttcatccTCTGTGACAGTGa 3'
 856 - 876 136.00 -16.40
2 
miRNA  3' aggcgGACAGAC----UUGUCAcu 5'
               || ||||    ||||||  
Target 5' ctttaCT-TCTGGGGAAACAGTtt 3'
 428 - 450 128.00 -8.80
3 
miRNA  3' aggcGGACAGACUUGUCACu 5'
              :|||||| | |:||| 
Target 5' agatTCTGTCTTACCGGTGc 3'
 12 - 31 120.00 -13.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31587500 6 COSMIC
COSN31500718 7 COSMIC
COSN31583745 9 COSMIC
COSN19047331 13 COSMIC
COSN27000320 104 COSMIC
COSN30511522 113 COSMIC
COSN18740603 127 COSMIC
COSN30103492 291 COSMIC
COSM9551812 339 COSMIC
COSM2799137 340 COSMIC
COSM3937291 341 COSMIC
COSM4064770 345 COSMIC
COSM8400843 367 COSMIC
COSM976644 373 COSMIC
COSM5437449 380 COSMIC
COSM4929693 381 COSMIC
COSM5981084 396 COSMIC
COSM7629243 405 COSMIC
COSM8994063 422 COSMIC
COSM5423062 460 COSMIC
COSM3819053 470 COSMIC
COSM1679371 471 COSMIC
COSM4064769 497 COSMIC
COSM6790427 511 COSMIC
COSM8092686 516 COSMIC
COSM8481007 516 COSMIC
COSM8035263 535 COSMIC
COSM8639272 544 COSMIC
COSN30447314 556 COSMIC
COSN31613763 578 COSMIC
COSN30149843 606 COSMIC
COSN30457651 606 COSMIC
COSN31558013 613 COSMIC
COSN31598865 617 COSMIC
COSN30674948 669 COSMIC
COSN31515762 672 COSMIC
COSN30119719 733 COSMIC
COSN13706988 762 COSMIC
COSN30497737 777 COSMIC
COSN18062732 778 COSMIC
COSN31573519 794 COSMIC
COSN31573529 830 COSMIC
COSM5016529 856 COSMIC
COSM9392435 862 COSMIC
COSM8243648 863 COSMIC
COSM1266800 873 COSMIC
COSM129435 904 COSMIC
COSM1609964 905 COSMIC
COSM4064768 924 COSMIC
COSM8453145 946 COSMIC
COSM3937290 947 COSMIC
COSM5640663 948 COSMIC
COSM6790424 973 COSMIC
COSM6428343 1001 COSMIC
COSM9921171 1006 COSMIC
COSM4730066 1062 COSMIC
COSN31599927 1074 COSMIC
COSN25558694 1098 COSMIC
COSN27000318 1103 COSMIC
COSN31554533 1107 COSMIC
COSN18041980 1148 COSMIC
COSN26440710 1191 COSMIC
COSN21517733 1311 COSMIC
COSN30378057 1401 COSMIC
COSN21565076 1447 COSMIC
COSN7162473 1643 COSMIC
COSN8241128 1688 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs747437340 3 dbSNP
rs762276377 5 dbSNP
rs1477130729 7 dbSNP
rs367780481 9 dbSNP
rs1401076800 19 dbSNP
rs140951255 21 dbSNP
rs1287478248 25 dbSNP
rs371305424 26 dbSNP
rs761098424 27 dbSNP
rs1014623213 28 dbSNP
rs775481749 31 dbSNP
rs561395220 37 dbSNP
rs746077123 38 dbSNP
rs774606553 41 dbSNP
rs1165080065 42 dbSNP
rs770603354 44 dbSNP
rs985068615 50 dbSNP
rs1306060902 57 dbSNP
rs950925260 58 dbSNP
rs1026956564 59 dbSNP
rs1352683836 61 dbSNP
rs111963625 69 dbSNP
rs1306862000 78 dbSNP
rs780582736 78 dbSNP
rs961125797 82 dbSNP
rs1229727826 88 dbSNP
rs544738497 89 dbSNP
rs1012023493 94 dbSNP
rs1002241259 95 dbSNP
rs903899013 96 dbSNP
rs1276399543 97 dbSNP
rs146419119 108 dbSNP
rs1195042097 110 dbSNP
rs558792171 111 dbSNP
rs892401339 116 dbSNP
rs1051427231 117 dbSNP
rs933850381 118 dbSNP
rs75933088 121 dbSNP
rs573098117 123 dbSNP
rs866264166 124 dbSNP
rs1039515495 127 dbSNP
rs1372672574 137 dbSNP
rs1460723759 148 dbSNP
rs745368110 162 dbSNP
rs1403426120 163 dbSNP
rs1061732 173 dbSNP
rs941073950 175 dbSNP
rs1323508405 177 dbSNP
rs1335365720 188 dbSNP
rs1228531419 196 dbSNP
rs1460661629 196 dbSNP
rs778629733 197 dbSNP
rs924572861 203 dbSNP
rs756900228 216 dbSNP
rs1226345262 218 dbSNP
rs1256359182 223 dbSNP
rs1484153175 225 dbSNP
rs944929467 226 dbSNP
rs1242513279 236 dbSNP
rs1460894356 239 dbSNP
rs1168970839 247 dbSNP
rs982460553 260 dbSNP
rs1392191526 270 dbSNP
rs553218976 273 dbSNP
rs766887655 273 dbSNP
rs1259657773 275 dbSNP
rs1185685754 282 dbSNP
rs777454429 284 dbSNP
rs756025561 286 dbSNP
rs748097779 288 dbSNP
rs1332975757 290 dbSNP
rs375441326 292 dbSNP
rs754581800 293 dbSNP
rs1198242047 294 dbSNP
rs751223644 298 dbSNP
rs1294118196 302 dbSNP
rs1382178629 318 dbSNP
rs143157273 322 dbSNP
rs1328353331 329 dbSNP
rs1438190640 334 dbSNP
rs201876645 336 dbSNP
rs764369833 338 dbSNP
rs761240669 344 dbSNP
rs1371248402 345 dbSNP
rs1169600822 346 dbSNP
rs1433736299 356 dbSNP
rs1262353578 364 dbSNP
rs369740761 368 dbSNP
rs1210575273 369 dbSNP
rs1333814264 372 dbSNP
rs767563893 374 dbSNP
rs759654207 379 dbSNP
rs774447773 383 dbSNP
rs1186124146 389 dbSNP
rs753551078 391 dbSNP
rs777661938 395 dbSNP
rs1249722026 398 dbSNP
rs1227254894 402 dbSNP
rs200376855 409 dbSNP
rs1354759011 416 dbSNP
rs149507864 426 dbSNP
rs1003225681 436 dbSNP
rs1306068222 437 dbSNP
rs763101686 438 dbSNP
rs1369749614 439 dbSNP
rs1331684517 440 dbSNP
rs377162534 445 dbSNP
rs769530524 448 dbSNP
rs748073301 456 dbSNP
rs763383117 456 dbSNP
rs1023491733 457 dbSNP
rs1297114495 458 dbSNP
rs1293707734 460 dbSNP
rs1466472510 463 dbSNP
rs781315596 464 dbSNP
rs768743634 468 dbSNP
rs746466959 470 dbSNP
rs77340213 471 dbSNP
rs1369287372 482 dbSNP
rs750767272 482 dbSNP
rs1182750670 483 dbSNP
rs1421111878 491 dbSNP
rs1248436871 493 dbSNP
rs1402807953 495 dbSNP
rs1009537490 500 dbSNP
rs567278233 501 dbSNP
rs769788684 503 dbSNP
rs778187514 514 dbSNP
rs1283137433 515 dbSNP
rs756486270 516 dbSNP
rs372876974 518 dbSNP
rs1310492466 520 dbSNP
rs1161848665 523 dbSNP
rs1240662744 524 dbSNP
rs1333675846 525 dbSNP
rs892430076 528 dbSNP
rs1473170121 530 dbSNP
rs368815579 533 dbSNP
rs1315152843 535 dbSNP
rs760060940 540 dbSNP
rs1377170903 549 dbSNP
rs751584409 551 dbSNP
rs766378266 553 dbSNP
rs558698941 557 dbSNP
rs763869723 558 dbSNP
rs773351524 561 dbSNP
rs769597237 562 dbSNP
rs998509389 563 dbSNP
rs761657041 566 dbSNP
rs776588530 574 dbSNP
rs1186341105 582 dbSNP
rs899691335 585 dbSNP
rs536759489 589 dbSNP
rs746947026 590 dbSNP
rs779612067 591 dbSNP
rs1362661350 593 dbSNP
rs888208636 598 dbSNP
rs890484087 600 dbSNP
rs1164877673 604 dbSNP
rs1366957060 606 dbSNP
rs929660453 609 dbSNP
rs570963841 618 dbSNP
rs552400594 619 dbSNP
rs932254216 624 dbSNP
rs920724249 626 dbSNP
rs532729839 628 dbSNP
rs940408099 642 dbSNP
rs926836214 644 dbSNP
rs1265710122 646 dbSNP
rs1212108910 655 dbSNP
rs1291383172 655 dbSNP
rs1483559803 657 dbSNP
rs980925006 660 dbSNP
rs1231609385 663 dbSNP
rs140095938 686 dbSNP
rs907605956 692 dbSNP
rs113656766 702 dbSNP
rs745938133 705 dbSNP
rs1386523401 706 dbSNP
rs1442291309 710 dbSNP
rs915336744 716 dbSNP
rs988148879 719 dbSNP
rs1411382970 720 dbSNP
rs1236974031 724 dbSNP
rs1353767320 725 dbSNP
rs1448667189 726 dbSNP
rs1304557773 728 dbSNP
rs1385060530 744 dbSNP
rs1331387715 748 dbSNP
rs1023292386 757 dbSNP
rs752473301 762 dbSNP
rs1030071318 763 dbSNP
rs35961025 764 dbSNP
rs1343152893 765 dbSNP
rs1216603937 772 dbSNP
rs530299555 774 dbSNP
rs1032566917 775 dbSNP
rs1437651427 783 dbSNP
rs1211411808 797 dbSNP
rs1245536348 799 dbSNP
rs771539748 803 dbSNP
rs745512745 804 dbSNP
rs1356742624 806 dbSNP
rs778471362 812 dbSNP
rs756936243 813 dbSNP
rs151214581 814 dbSNP
rs781539118 816 dbSNP
rs755416056 818 dbSNP
rs1383054158 824 dbSNP
rs374791115 826 dbSNP
rs142227912 827 dbSNP
rs760176866 828 dbSNP
rs1162899574 830 dbSNP
rs1476183526 840 dbSNP
rs1475151533 846 dbSNP
rs376035038 847 dbSNP
rs1243270658 848 dbSNP
rs1195767653 851 dbSNP
rs138106032 859 dbSNP
rs765340372 860 dbSNP
rs1334067078 862 dbSNP
rs1450459893 863 dbSNP
rs762132935 865 dbSNP
rs767465041 867 dbSNP
rs1270706647 869 dbSNP
rs1050423985 878 dbSNP
rs1291429472 879 dbSNP
rs932180494 881 dbSNP
rs150371285 882 dbSNP
rs760685466 883 dbSNP
rs1339086353 886 dbSNP
rs769313154 887 dbSNP
rs1220208169 891 dbSNP
rs1038390828 893 dbSNP
rs940852219 896 dbSNP
rs1265468973 900 dbSNP
rs775329550 902 dbSNP
rs1428565394 907 dbSNP
rs771587282 910 dbSNP
rs775126066 910 dbSNP
rs1248101999 912 dbSNP
rs745313736 914 dbSNP
rs1323997699 917 dbSNP
rs750437545 921 dbSNP
rs770500874 922 dbSNP
rs748949336 924 dbSNP
rs1461043958 932 dbSNP
rs1420337262 939 dbSNP
rs1170083545 941 dbSNP
rs1474731969 943 dbSNP
rs1372818564 945 dbSNP
rs1194710819 946 dbSNP
rs1201324683 947 dbSNP
rs373333825 948 dbSNP
rs142355333 961 dbSNP
rs747532264 968 dbSNP
rs1046885558 972 dbSNP
rs1342388006 973 dbSNP
rs1334972922 974 dbSNP
rs780379801 975 dbSNP
rs1385730328 977 dbSNP
rs949147831 979 dbSNP
rs1316440080 985 dbSNP
rs375998142 986 dbSNP
rs1212691394 989 dbSNP
rs1386740596 991 dbSNP
rs1338687517 992 dbSNP
rs758978162 998 dbSNP
rs200298697 1006 dbSNP
rs1326078851 1007 dbSNP
rs1458161251 1010 dbSNP
rs750404787 1014 dbSNP
rs1373456621 1020 dbSNP
rs765422725 1032 dbSNP
rs757541456 1033 dbSNP
rs990464066 1034 dbSNP
rs754179577 1035 dbSNP
rs1223402922 1037 dbSNP
rs1417760647 1039 dbSNP
rs763949797 1043 dbSNP
rs372405299 1045 dbSNP
rs147659060 1047 dbSNP
rs147065197 1049 dbSNP
rs759520245 1055 dbSNP
rs773674415 1057 dbSNP
rs1283043361 1063 dbSNP
rs770482385 1073 dbSNP
rs748930855 1076 dbSNP
rs186118106 1079 dbSNP
rs368381442 1082 dbSNP
rs1191861632 1086 dbSNP
rs747298383 1089 dbSNP
rs201269732 1091 dbSNP
rs780474231 1093 dbSNP
rs1045256517 1096 dbSNP
rs375980768 1097 dbSNP
rs76186241 1099 dbSNP
rs374738239 1100 dbSNP
rs779131384 1103 dbSNP
rs1471161288 1105 dbSNP
rs988278703 1107 dbSNP
rs1374395322 1108 dbSNP
rs1384420988 1110 dbSNP
rs1425530687 1115 dbSNP
rs536565100 1115 dbSNP
rs1293276820 1119 dbSNP
rs1305234987 1123 dbSNP
rs573560934 1126 dbSNP
rs765315304 1130 dbSNP
rs956994608 1140 dbSNP
rs899188065 1149 dbSNP
rs556542327 1152 dbSNP
rs1338059289 1154 dbSNP
rs1236186020 1163 dbSNP
rs1467814306 1164 dbSNP
rs536646739 1165 dbSNP
rs1289167270 1166 dbSNP
rs1490113355 1174 dbSNP
rs1205613296 1176 dbSNP
rs1252509013 1177 dbSNP
rs1435995135 1179 dbSNP
rs1181083815 1180 dbSNP
rs571050022 1184 dbSNP
rs558600858 1185 dbSNP
rs1165655327 1191 dbSNP
rs776873712 1195 dbSNP
rs551045573 1204 dbSNP
rs1299118243 1206 dbSNP
rs1046552933 1208 dbSNP
rs538887914 1211 dbSNP
rs1328830996 1212 dbSNP
rs768804438 1218 dbSNP
rs1382820170 1221 dbSNP
rs916344644 1225 dbSNP
rs964042700 1233 dbSNP
rs1372873823 1235 dbSNP
rs761081349 1243 dbSNP
rs1018207474 1252 dbSNP
rs1451906561 1254 dbSNP
rs56212798 1256 dbSNP
rs1252849090 1262 dbSNP
rs1337251921 1265 dbSNP
rs374109887 1265 dbSNP
rs1054829631 1266 dbSNP
rs1005470021 1268 dbSNP
rs936332322 1271 dbSNP
rs924978591 1274 dbSNP
rs140491317 1275 dbSNP
rs1440832923 1276 dbSNP
rs967035224 1282 dbSNP
rs1201259608 1289 dbSNP
rs1338429276 1291 dbSNP
rs1375113142 1296 dbSNP
rs546842781 1299 dbSNP
rs986648278 1306 dbSNP
rs533718523 1309 dbSNP
rs1454061776 1317 dbSNP
rs1334104239 1321 dbSNP
rs1381488874 1336 dbSNP
rs895573955 1337 dbSNP
rs530430192 1341 dbSNP
rs1305503860 1342 dbSNP
rs1226465381 1343 dbSNP
rs1029065849 1345 dbSNP
rs1201764204 1347 dbSNP
rs7216291 1354 dbSNP
rs551039635 1358 dbSNP
rs1187278046 1365 dbSNP
rs1264158540 1366 dbSNP
rs746378687 1373 dbSNP
rs7222251 1374 dbSNP
rs529465828 1383 dbSNP
rs565410027 1384 dbSNP
rs1465684187 1387 dbSNP
rs545507812 1388 dbSNP
rs147622777 1389 dbSNP
rs559510129 1391 dbSNP
rs922684286 1393 dbSNP
rs561811266 1396 dbSNP
rs573645225 1397 dbSNP
rs556827489 1398 dbSNP
rs1013693718 1400 dbSNP
rs895340776 1401 dbSNP
rs1282583080 1404 dbSNP
rs1054799867 1406 dbSNP
rs984065267 1414 dbSNP
rs952588784 1421 dbSNP
rs1485007652 1426 dbSNP
rs1025544919 1428 dbSNP
rs543048386 1429 dbSNP
rs924935742 1433 dbSNP
rs1197833620 1435 dbSNP
rs1207034355 1437 dbSNP
rs1342684402 1438 dbSNP
rs1419083541 1439 dbSNP
rs1290878187 1440 dbSNP
rs1226546554 1444 dbSNP
rs1042447825 1445 dbSNP
rs945288180 1450 dbSNP
rs912494663 1451 dbSNP
rs1402902056 1452 dbSNP
rs1282480370 1453 dbSNP
rs1373982316 1459 dbSNP
rs543542722 1464 dbSNP
rs770586229 1465 dbSNP
rs557439675 1466 dbSNP
rs953858300 1469 dbSNP
rs1412046399 1471 dbSNP
rs1021233936 1472 dbSNP
rs531585600 1473 dbSNP
rs974823248 1476 dbSNP
rs1011138869 1477 dbSNP
rs564550434 1478 dbSNP
rs1016243447 1479 dbSNP
rs145446023 1480 dbSNP
rs56664509 1484 dbSNP
rs375792133 1489 dbSNP
rs536833752 1490 dbSNP
rs746916372 1494 dbSNP
rs1469726278 1497 dbSNP
rs1410019972 1498 dbSNP
rs1184634457 1504 dbSNP
rs567996006 1505 dbSNP
rs1195688531 1506 dbSNP
rs752182254 1507 dbSNP
rs768602608 1507 dbSNP
rs1219222873 1513 dbSNP
rs1302288614 1515 dbSNP
rs1354961933 1516 dbSNP
rs1453232612 1517 dbSNP
rs28572614 1518 dbSNP
rs11334122 1519 dbSNP
rs1289615626 1519 dbSNP
rs1446175125 1519 dbSNP
rs369083266 1519 dbSNP
rs397740526 1519 dbSNP
rs1308491278 1520 dbSNP
rs1491181208 1520 dbSNP
rs911248459 1521 dbSNP
rs531203976 1522 dbSNP
rs1033816950 1523 dbSNP
rs1183680361 1523 dbSNP
rs1244504840 1524 dbSNP
rs1442387559 1525 dbSNP
rs1162324931 1528 dbSNP
rs1168184218 1529 dbSNP
rs1411473673 1529 dbSNP
rs1446056232 1529 dbSNP
rs918507985 1529 dbSNP
rs931274296 1529 dbSNP
rs1222700589 1530 dbSNP
rs972637857 1530 dbSNP
rs1228669751 1532 dbSNP
rs1326535118 1535 dbSNP
rs1283877963 1537 dbSNP
rs571686203 1538 dbSNP
rs551447432 1539 dbSNP
rs1000579269 1541 dbSNP
rs1216690636 1541 dbSNP
rs1271427715 1546 dbSNP
rs537539222 1547 dbSNP
rs1204931593 1550 dbSNP
rs1264425442 1551 dbSNP
rs1351440791 1551 dbSNP
rs1293327534 1552 dbSNP
rs1434821260 1559 dbSNP
rs1476233292 1561 dbSNP
rs960186152 1564 dbSNP
rs1042025592 1566 dbSNP
rs528591388 1570 dbSNP
rs541194344 1571 dbSNP
rs1051002481 1575 dbSNP
rs3205847 1578 dbSNP
rs1408364926 1581 dbSNP
rs1412864041 1582 dbSNP
rs969763357 1594 dbSNP
rs921060927 1595 dbSNP
rs974332042 1597 dbSNP
rs1473054181 1602 dbSNP
rs1428917872 1609 dbSNP
rs942099872 1614 dbSNP
rs1189218168 1615 dbSNP
rs1224638581 1617 dbSNP
rs909276838 1617 dbSNP
rs983577964 1626 dbSNP
rs950715822 1627 dbSNP
rs1024966163 1630 dbSNP
rs992336215 1632 dbSNP
rs550933525 1633 dbSNP
rs542848575 1634 dbSNP
rs1480671916 1635 dbSNP
rs1269509632 1636 dbSNP
rs1201418911 1637 dbSNP
rs112827195 1639 dbSNP
rs1031708179 1640 dbSNP
rs1252387923 1642 dbSNP
rs1298789113 1644 dbSNP
rs1402663789 1646 dbSNP
rs1296648340 1651 dbSNP
rs1405939627 1652 dbSNP
rs778573676 1656 dbSNP
rs181150923 1657 dbSNP
rs1279600120 1659 dbSNP
rs543333801 1661 dbSNP
rs1284878709 1664 dbSNP
rs1490432049 1671 dbSNP
rs1142116 1672 dbSNP
rs754598915 1673 dbSNP
rs1142118 1675 dbSNP
rs1450936602 1677 dbSNP
rs1386481667 1681 dbSNP
rs866250865 1685 dbSNP
rs1041200207 1689 dbSNP
rs1364444400 1689 dbSNP
rs780855878 1696 dbSNP
rs1007039457 1702 dbSNP
rs1379950359 1705 dbSNP
rs189932514 1706 dbSNP
rs889887292 1707 dbSNP
rs1048475477 1709 dbSNP
rs185862100 1712 dbSNP
rs1457873792 1717 dbSNP
rs1358798218 1724 dbSNP
rs899763663 1727 dbSNP
rs1330212308 1731 dbSNP
rs1336954526 1736 dbSNP
rs1443938444 1737 dbSNP
rs918594319 1749 dbSNP
rs1174290624 1761 dbSNP
rs1247772570 1761 dbSNP
rs1263455041 1764 dbSNP
rs149338852 1769 dbSNP
rs1196247988 1771 dbSNP
rs1425613606 1784 dbSNP
rs1185818998 1785 dbSNP
rs1439594044 1787 dbSNP
rs1176881406 1790 dbSNP
rs1237698417 1792 dbSNP
rs1445430792 1799 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aggcggacAGAC-UUGUCacu 5'
                  |||| :||||   
Target 5' uuucauccUCUGUGACAG--- 3'
 		12 - 29
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000301364.5 | 3UTR | CCUCACcuuaauuucauccucugugacag
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla 0.544 2.7e-2 0.522 3.4e-2 13 Click to see details
GSE38226 Liver fibrosis 0.306 8.9e-2 0.055 4.1e-1 21 Click to see details
GSE28544 Breast cancer 0.271 1.0e-1 0.100 3.2e-1 24 Click to see details
GSE26953 Aortic valvular endothelial cells -0.167 2.2e-1 -0.279 9.3e-2 24 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.149 2.4e-1 -0.104 3.1e-1 25 Click to see details
GSE32688 Pancreatic cancer 0.088 3.2e-1 0.024 4.5e-1 32 Click to see details
GSE42095 Differentiated embryonic stem cells 0.032 4.4e-1 0.018 4.7e-1 23 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
55 hsa-miR-1208 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT076103 ADORA2B adenosine A2b receptor 2 2
MIRT447464 OSMR oncostatin M receptor 2 2
MIRT448145 ESF1 ESF1 nucleolar pre-rRNA processing protein homolog 2 2
MIRT463639 YY1 YY1 transcription factor 2 4
MIRT465065 TSR1 TSR1, ribosome maturation factor 2 2
MIRT468464 SET SET nuclear proto-oncogene 2 4
MIRT480171 CALM3 calmodulin 3 2 2
MIRT481495 ARL6IP1 ADP ribosylation factor like GTPase 6 interacting protein 1 2 8
MIRT484111 ABCD2 ATP binding cassette subfamily D member 2 2 4
MIRT499834 PCSK9 proprotein convertase subtilisin/kexin type 9 2 8
MIRT500261 ZNF788 zinc finger family member 788 2 6
MIRT500551 XBP1P1 X-box binding protein 1 pseudogene 1 2 8
MIRT502697 CSNK1G1 casein kinase 1 gamma 1 2 4
MIRT517786 EFCAB11 EF-hand calcium binding domain 11 2 2
MIRT519191 IVD isovaleryl-CoA dehydrogenase 2 2
MIRT523114 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT527425 NRL neural retina leucine zipper 2 2
MIRT529509 IYD iodotyrosine deiodinase 2 2
MIRT533705 TMEM67 transmembrane protein 67 2 2
MIRT535694 NEURL1B neuralized E3 ubiquitin protein ligase 1B 2 2
MIRT536141 MAPK14 mitogen-activated protein kinase 14 2 2
MIRT544878 ZNF543 zinc finger protein 543 2 4
MIRT551362 EPM2AIP1 EPM2A interacting protein 1 2 2
MIRT555949 NUCKS1 nuclear casein kinase and cyclin dependent kinase substrate 1 2 2
MIRT561498 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT569681 AMACR alpha-methylacyl-CoA racemase 2 2
MIRT572518 KIAA0232 KIAA0232 2 2
MIRT572877 OPHN1 oligophrenin 1 2 2
MIRT572924 PRAMEF1 PRAME family member 1 2 2
MIRT607528 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT611076 ZNF621 zinc finger protein 621 2 2
MIRT613236 CCDC39 coiled-coil domain containing 39 2 2
MIRT616542 NFATC2 nuclear factor of activated T-cells 2 2 2
MIRT620010 CCDC137 coiled-coil domain containing 137 2 2
MIRT621491 STYK1 serine/threonine/tyrosine kinase 1 2 2
MIRT622379 SALL1 spalt like transcription factor 1 2 2
MIRT628226 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT636458 LRCH3 leucine rich repeats and calponin homology domain containing 3 2 2
MIRT636546 FAM126B family with sequence similarity 126 member B 2 2
MIRT637350 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT637604 ZNF554 zinc finger protein 554 2 2
MIRT637732 EXO5 exonuclease 5 2 2
MIRT638697 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT640634 ZIC4 Zic family member 4 2 2
MIRT641535 SNW1 SNW domain containing 1 2 2
MIRT648796 VPS8 VPS8, CORVET complex subunit 2 2
MIRT663060 LRIF1 ligand dependent nuclear receptor interacting factor 1 2 2
MIRT666581 RHOBTB3 Rho related BTB domain containing 3 2 2
MIRT699206 FYN FYN proto-oncogene, Src family tyrosine kinase 2 2
MIRT704875 CD164 CD164 molecule 2 2
MIRT706850 DNAJB13 DnaJ heat shock protein family (Hsp40) member B13 2 2
MIRT712941 CCBE1 collagen and calcium binding EGF domains 1 2 3
MIRT714653 FSTL1 follistatin like 1 2 2
MIRT722320 SH2D1A SH2 domain containing 1A 2 2
MIRT722535 EPRS glutamyl-prolyl-tRNA synthetase 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-1 Anthocyanin NULL 145858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Caffeic acid NULL 689043 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Catechin approved 9064 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Curcumin NULL 969516 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Ferulic acid NULL 445858 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Hesperidin NULL 10621 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-1 Quercetin NULL 5280343 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-1 Galactose NULL 6036 Quantitative real-time PCR lens 22736950 2012 up-regulated
miR-1 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Quantitative real-time PCR myocardial differentiation of mouse ES cells 19521018 2009 down-regulated
miR-1 Sulfonyl-hydrazone-1 (SHZ) NULL NULL Quantitative real-time PCR Murine broblast-derived Induced pluripotent stem cells 21445862 2011 up-regulated
miR-1 Cocaine NULL 446220 Next-generation sequencing ventral striatum 21708909 2011 up-regulated
miR-1 Atorvastatin approved 60823 Quantitative real-time PCR Cardiomyocyte 23860036 2013 down-regualted
miR-1 Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-1 Docosahexaenoic acid NULL 445580 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 Palmitic acid approved 985 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miR-1 17beta-estradiol (E2) approved 5757 Microarray MCF-7AKT breast cancer cells 19528081 2009 down-regulated
miR-1 Essential amino acids (EAA) NULL NULL Quantitative real-time PCR skeletal muscle of young adults 19828686 2009 up-regulated
miR-1 Hydrogen peroxide (H2O2) NULL 784 Quantitative real-time PCR Human umbilical vein endothelial cells 21527937 2011 down-regulated
miR-1 Trichostatin A (TSA) NULL 444732 Microarray apoptosis-resistant breast cancer cells 21971930 2011 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-1 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-1 Bicalutamide approved 2375 Microarray prostate 22674191 2012 up-regulated
miR-1 Arsenic trioxide approved 14888 Quantitative real-time PCR cardia 22889704 2012 up-regulated
miR-1 Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-1 Quinidine approved 441074 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 up-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR myocardial infarction (MI) rats 19775284 2009 down-regulated
miR-1 Tanshinone IIA NULL 164676 Quantitative real-time PCR post-infarction rat cardiomyocytes 21220930 2011 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 down-regulated
miR-1 Dexamethasone approved 5743 Microarray adrenals and granulosa cells 24205079 2014 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 up-regulated
miR-1 Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 down-regulated
miR-1 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1208 Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-1208 Sunitinib 5329102 NSC750690 approved sensitive High Renal Cell Cancer tissue
hsa-miR-1208 Cisplatin 5460033 NSC119875 approved sensitive Low Renal Cell Cancer cell line (Caki-1)
hsa-mir-1208 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-1208 Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-mir-1208 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-miR-1208 Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-1208 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-1208 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-1208 Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-1208 Cisplatin 5460033 NSC119875 approved sensitive cell line (RPMI2650)
hsa-miR-1208 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-1208 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-1208 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-1208 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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