miRTarBase - #MIRT465704


—
pre-miRNA Information
pre-miRNA hsa-mir-3689a   
Genomic Coordinates chr9: 134849487 - 134849564
Description Homo sapiens miR-3689a stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3689a-5p
Sequence 10| UGUGAUAUCAUGGUUCCUGGGA |31
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs866098973 7 dbSNP
rs1203092136 8 dbSNP
rs1275806724 10 dbSNP
rs1264215348 13 dbSNP
rs1203436967 16 dbSNP
rs1170643534 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TNFAIP1   
Synonyms B12, B61, BTBD34, EDP1, hBACURD2
Description TNF alpha induced protein 1
Transcript NM_021137   
Expression
Putative miRNA Targets on TNFAIP1
3'UTR of TNFAIP1
(miRNA target sites are highlighted)		 
>TNFAIP1|NM_021137|3'UTR
   1 CCAGACCCTCAGGGAGTCAGGGCACGGGAGGCCCTATCTCCCATCCTGTGGAACCCGCCCCATTGGCCACCCCATGCTGC
  81 TGCTGCCTGGGTCTCTGCTCTAGCACCCAGAGGCATGACAGGCCCTGCTCAGAGGTCAGAGGGTCTGGGCAGAGGAGGGA
 161 CCACATTCCCCTGCCTTGCCCCTGAGCACTTCTGGAGACTGCGTCCTGTCCTATCTGCTCACCATCACCCTTCCTGCCCG
 241 ACGGAGCTGCTTCTGCTCCCTGGGGCATATGGACTGACCCACCTCCTGCTGAGAACCTTCCCCTAGGCCCTGTGCAGAAG
 321 GCTACTGCCCCTTAGGCCTCAGCTGGGGGAAAGGCAGTTCTGGTGCTGTAGAGGCCCTGGTGCAGAAAGTGGGACGTCTT
 401 TTTTCCTAAGGTGTTTAAGCACAGGCTTGATAAGTTTGGTTTTTAAAAAATAATCTAGGAAATGAATAATTCTAAATCTA
 481 GTAATGAGGAAACTGAGCATTTCTTTTGCCCTCCAGGGTGCCAAGACCCTACATATGACAGAACCCTTGGCCCTTCTCCA
 561 TGCCTGTGGGATCTGTTTCTTTAAAGCACTTTGTACTGTTATTCAGGAGGTTGATAATCTCCTTGACCCATGTCTTTCTA
 641 CCCTAATCCCCACTTCCCTGCAGAATCAATCTGAGGGAGGGGATAAAGAGGAAGCAATAAAAAAAAAACATCCGACAGAG
 721 CAGCTCTGGCTTTGCAGCCTGGCCAGCAGCTCAGAGTGCACCGAGGAGGGAAGGATGGCTAAGCTGGGACCGGCAGTCCT
 801 CACAGGGTGCCTGTGAGAAAGGACATTTTACCCCCACATCATAGTCACATCACTGACTCCTAGGTCTAGCACGACTGCTC
 881 TTTGTGATTCTCTTGAGTACCCTTGGCTTCCAGCCATGCTGTCCTCACATACGGTAAAGCCAAAGAGCTGTCACATGGGC
 961 CAGAAACATGAGCCACGGCAGGAAGACCGTGGAGCCCGTGGGCACTGCATGGTGTTGGCTGGCATGCCCATCAGCTGAGG
1041 ACAGCAAACTCCCAGCAGCCCCTACAGAGGTGGCACATGCTTGGCCACACATCTACTCCCTGCCCACACCATCTATGCTC
1121 TTGGTTGGTGCTGGCTGGGATGGCGGTTCTGCCCAGTGGTGTCTCTGAGCGCGGGATGACAGGAGCAACCGAAGCACCCT
1201 GAAGGCCTTCACTCCTTGTTGGGTAACTCAGCCATGGAGATGCCAAGCACTAGCCAGGAGGTGAGTTCCTCTTTAGGGCT
1281 TTGGTTTTCATTCCTTTTTGTTTGGCTTGGCCAAACCAGAATTCAGCTTATCTGAATTATTTTCCAAAGGAATGCTGTCA
1361 GGGAGGGACTGTTCTGCCAGCCTAACAAAGCAACGTAGCCACGTATAGTACCCACTTTCTGCTCTTTGGAGAGAACACAG
1441 GTTATCAAGTTCATCTCTCTTGACTACTCTTATGATAGCTGATGCCACAGAGCCTATGGGCAAATGCCAGACCCAGGGTT
1521 AGACACAAGGACCTGAAGTGACATGACGGCGGGACAGGGGAAATGTGACTTTCTAATTAGGCATTTTATGTTAGTCACAG
1601 TCTTGAATGTATAAACAGCACTAAGACTCTCAGGTCAGGTACCTTGGTGATCAGCTACTAGTTCTTCCAGCCCTCATTGA
1681 GGTAACAAGATAAAGACAAATCCACTTCTTTGGCCAAATTCAGGCTTTGGCTTTATGACTTTCCCACAGAGACTGGAATG
1761 CGTCAGCCTGAGACCACTGGCCTATTTTCTCAGCTGCCCTCTTGAGGTCCTTTAACACTCAAATTCCCAGCTCCCCACTG
1841 AGGTGTTGTGATGCTTGCCTTTTGACCTCCCCATCCCCTTTAGTCCCTGCTTACTACTTTGACATTCACATCCTCAGTGT
1921 CTCAGTCTTTTTTGCCGAGAAAGCACAGTAGTCTGGGACTGGGCATTTATCTTCTCTGACTGAAAATCTCTCCTTGGTCT
2001 TAAGGAAAATACTAACATTGAACTCACTGACATGATCTTAGCTTCTTTAATCAGACTTTGTGACTTAAAAGTTTGGGGGT
2081 TTTCTTTGAAAGTTTCCAGCCCTATTCAGAAAGCAACTCTTGGCTGTGTGCATTTTTCAACTCCAAGCAGCCCAGGGGTA
2161 AGTAAACAAAGTATGGATGAAGGTCAGATTTTCTTGTCAGTTTCTGAGAAACCTGGCAGCCTGCTGTTAACAACACAGGC
2241 CAGTATTGGGTTTTATTGAATTTGGTATGTGACCAAGGTCGGCCTAAAGGATGGCGCAGGTCCTGGGCAGGAAAGAATTT
2321 TTCCTTTATCACATAACTGTAATATTTGGTTGCTCAGCATAAGTGATGGAAGCAAACACTAATTTCTAATAAAATTGTGT
2401 TAAACTCAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agGGUCCUUGGUACUAUAGUGu 5'
            ||| || ||   |||| || 
Target 5' tgCCAAGACCCTACATATGACa 3'
 519 - 540 128.00 -11.60
2 
miRNA  3' aggGUCCUU---------GGUACUAUAGUGu 5'
             ||||||         || |  |||||| 
Target 5' gggCAGGAAAGAATTTTTCCTT--TATCACa 3'
 2305 - 2333 122.00 -14.10
3 
miRNA  3' aggguccuugGUACUAU-AGUGu 5'
                    ||| ||| |||| 
Target 5' tttacccccaCATCATAGTCACa 3'
 827 - 849 120.00 -12.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31562749 12 COSMIC
COSN30501522 27 COSMIC
COSN28873877 31 COSMIC
COSN30480284 41 COSMIC
COSN30450116 42 COSMIC
COSN31538601 58 COSMIC
COSN26999236 73 COSMIC
COSN5838903 89 COSMIC
COSN30505314 105 COSMIC
COSN31532974 203 COSMIC
COSN31542881 244 COSMIC
COSN20626118 259 COSMIC
COSN20113720 322 COSMIC
COSN6101116 361 COSMIC
COSN31483331 395 COSMIC
COSN8602817 475 COSMIC
COSN22547896 676 COSMIC
COSN20113726 736 COSMIC
COSN1715904 808 COSMIC
COSN6101117 864 COSMIC
COSN24044863 1391 COSMIC
COSN23833003 1473 COSMIC
COSN28322125 1541 COSMIC
COSN31779187 1792 COSMIC
COSN21535922 1855 COSMIC
COSN32065666 1914 COSMIC
COSN31961304 2325 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs781820164 12 dbSNP
rs781887809 12 dbSNP
rs1029869131 15 dbSNP
rs782129734 16 dbSNP
rs782516507 19 dbSNP
rs955438078 21 dbSNP
rs782632651 23 dbSNP
rs1007003269 24 dbSNP
rs368989668 26 dbSNP
rs555631932 27 dbSNP
rs957619255 29 dbSNP
rs782479986 35 dbSNP
rs782590499 41 dbSNP
rs782295167 45 dbSNP
rs1352521753 49 dbSNP
rs1299674601 55 dbSNP
rs1433959322 57 dbSNP
rs1349079468 58 dbSNP
rs1324203570 65 dbSNP
rs574220898 71 dbSNP
rs782393879 73 dbSNP
rs1409155866 76 dbSNP
rs1157720770 80 dbSNP
rs541350070 87 dbSNP
rs559652770 101 dbSNP
rs1409626325 103 dbSNP
rs1189083507 106 dbSNP
rs577193720 114 dbSNP
rs1247622700 120 dbSNP
rs966631434 126 dbSNP
rs1463898629 127 dbSNP
rs977890852 128 dbSNP
rs373244085 140 dbSNP
rs1331501617 145 dbSNP
rs1299542792 146 dbSNP
rs544573804 151 dbSNP
rs1366704369 165 dbSNP
rs1275168753 166 dbSNP
rs1443053354 167 dbSNP
rs1386279711 180 dbSNP
rs939089652 184 dbSNP
rs1319315096 189 dbSNP
rs990540625 191 dbSNP
rs782539498 194 dbSNP
rs115170044 201 dbSNP
rs941028776 203 dbSNP
rs530484581 204 dbSNP
rs897393831 208 dbSNP
rs1195850909 212 dbSNP
rs185848165 215 dbSNP
rs1051247363 224 dbSNP
rs1189762330 231 dbSNP
rs1486929382 232 dbSNP
rs891328901 240 dbSNP
rs560924980 241 dbSNP
rs1018777681 243 dbSNP
rs893101838 244 dbSNP
rs1362746858 245 dbSNP
rs528330783 255 dbSNP
rs1296867596 261 dbSNP
rs546563236 265 dbSNP
rs1363512965 276 dbSNP
rs782189020 283 dbSNP
rs1300518994 284 dbSNP
rs1465264929 288 dbSNP
rs571593439 289 dbSNP
rs538957586 292 dbSNP
rs1175938112 297 dbSNP
rs1428286320 305 dbSNP
rs1389940761 306 dbSNP
rs1169829517 307 dbSNP
rs1430761884 308 dbSNP
rs1254204693 309 dbSNP
rs966579469 312 dbSNP
rs1483708951 315 dbSNP
rs368008249 320 dbSNP
rs5819840 320 dbSNP
rs75080325 323 dbSNP
rs1203274198 325 dbSNP
rs1339848010 332 dbSNP
rs11550487 333 dbSNP
rs978006426 337 dbSNP
rs1228096592 342 dbSNP
rs1309147332 343 dbSNP
rs1309965299 345 dbSNP
rs189051124 348 dbSNP
rs1034785533 350 dbSNP
rs1379248156 353 dbSNP
rs1314403530 358 dbSNP
rs1407583933 377 dbSNP
rs1370386807 381 dbSNP
rs1308972745 386 dbSNP
rs960549838 394 dbSNP
rs181687343 395 dbSNP
rs3093695 396 dbSNP
rs555868348 397 dbSNP
rs11550489 399 dbSNP
rs1424534277 404 dbSNP
rs1420070359 407 dbSNP
rs1180348898 418 dbSNP
rs1482822320 420 dbSNP
rs1250844842 421 dbSNP
rs1196095226 426 dbSNP
rs1481585660 431 dbSNP
rs116332866 435 dbSNP
rs1243972620 445 dbSNP
rs1334964045 450 dbSNP
rs1294573145 454 dbSNP
rs1226221355 456 dbSNP
rs1349422801 457 dbSNP
rs918283510 463 dbSNP
rs535246430 473 dbSNP
rs1393558627 477 dbSNP
rs553170233 478 dbSNP
rs1389014762 480 dbSNP
rs1293496624 494 dbSNP
rs930199317 501 dbSNP
rs1051359186 504 dbSNP
rs1458844479 506 dbSNP
rs1396809411 508 dbSNP
rs1156986446 510 dbSNP
rs891259801 529 dbSNP
rs1412905497 533 dbSNP
rs1184237437 536 dbSNP
rs556668726 537 dbSNP
rs1264964616 538 dbSNP
rs1209219253 546 dbSNP
rs1468822836 547 dbSNP
rs1274509430 551 dbSNP
rs1206215977 552 dbSNP
rs1327850653 553 dbSNP
rs1039905866 561 dbSNP
rs186389870 562 dbSNP
rs1329758553 566 dbSNP
rs1300955453 567 dbSNP
rs1442320558 571 dbSNP
rs1318640329 575 dbSNP
rs374010963 575 dbSNP
rs1456835926 590 dbSNP
rs576554281 592 dbSNP
rs1160555061 597 dbSNP
rs1389468655 597 dbSNP
rs1464714430 599 dbSNP
rs1375744564 602 dbSNP
rs1197815748 612 dbSNP
rs1454664942 619 dbSNP
rs893207232 623 dbSNP
rs1186589872 629 dbSNP
rs1464077904 636 dbSNP
rs3093696 640 dbSNP
rs542349857 649 dbSNP
rs782371983 663 dbSNP
rs1020689709 664 dbSNP
rs1342385548 670 dbSNP
rs561073998 671 dbSNP
rs999372683 674 dbSNP
rs528252319 677 dbSNP
rs782175638 682 dbSNP
rs1235410036 685 dbSNP
rs1373632060 691 dbSNP
rs1296132675 699 dbSNP
rs1434977956 699 dbSNP
rs546789094 705 dbSNP
rs991055148 710 dbSNP
rs1320317075 715 dbSNP
rs1394542845 715 dbSNP
rs1401692838 720 dbSNP
rs1174479962 726 dbSNP
rs1435171832 733 dbSNP
rs11394711 735 dbSNP
rs869180608 735 dbSNP
rs1166695946 740 dbSNP
rs1448742130 748 dbSNP
rs1023509034 750 dbSNP
rs962759759 751 dbSNP
rs1242223458 753 dbSNP
rs1194611754 757 dbSNP
rs973878721 760 dbSNP
rs1255117656 764 dbSNP
rs1211153639 769 dbSNP
rs1350554024 774 dbSNP
rs1272910007 775 dbSNP
rs1228347029 788 dbSNP
rs1340631255 789 dbSNP
rs1272007694 792 dbSNP
rs1242770229 793 dbSNP
rs370362972 796 dbSNP
rs572600528 804 dbSNP
rs1339937503 808 dbSNP
rs1313755407 813 dbSNP
rs1416832220 814 dbSNP
rs1377068278 816 dbSNP
rs951029461 820 dbSNP
rs781994303 823 dbSNP
rs1305908589 826 dbSNP
rs1409303689 871 dbSNP
rs1420073226 873 dbSNP
rs1169568397 874 dbSNP
rs1471563123 887 dbSNP
rs376089557 890 dbSNP
rs1188282302 893 dbSNP
rs868976308 901 dbSNP
rs1250109124 902 dbSNP
rs782145616 904 dbSNP
rs1438737854 920 dbSNP
rs1275798323 921 dbSNP
rs1208541615 925 dbSNP
rs1040256765 933 dbSNP
rs782417103 934 dbSNP
rs555421748 944 dbSNP
rs1286239300 946 dbSNP
rs1441288301 951 dbSNP
rs1354894846 956 dbSNP
rs1330861012 969 dbSNP
rs781918036 976 dbSNP
rs903155079 977 dbSNP
rs1164963144 978 dbSNP
rs1475988210 979 dbSNP
rs1002839028 983 dbSNP
rs1176260402 987 dbSNP
rs1057095465 989 dbSNP
rs896406105 990 dbSNP
rs1220031223 991 dbSNP
rs550939658 999 dbSNP
rs1023876857 1003 dbSNP
rs75945208 1004 dbSNP
rs1267816635 1009 dbSNP
rs782296055 1010 dbSNP
rs1373847160 1017 dbSNP
rs995641651 1020 dbSNP
rs1281026803 1029 dbSNP
rs1025407429 1030 dbSNP
rs149766082 1032 dbSNP
rs1434261072 1043 dbSNP
rs370619251 1050 dbSNP
rs1370077530 1051 dbSNP
rs1326015457 1062 dbSNP
rs1462621294 1070 dbSNP
rs951144173 1089 dbSNP
rs986461788 1095 dbSNP
rs912253781 1103 dbSNP
rs1400873923 1105 dbSNP
rs1410660105 1106 dbSNP
rs782065586 1113 dbSNP
rs376791645 1116 dbSNP
rs192143673 1118 dbSNP
rs537484278 1119 dbSNP
rs1196052709 1121 dbSNP
rs1463633645 1123 dbSNP
rs549185809 1125 dbSNP
rs3093697 1131 dbSNP
rs1216802042 1139 dbSNP
rs1318920942 1144 dbSNP
rs924693140 1145 dbSNP
rs369437455 1146 dbSNP
rs1346869297 1155 dbSNP
rs1304118722 1162 dbSNP
rs1442978614 1162 dbSNP
rs1287740518 1166 dbSNP
rs1362422410 1166 dbSNP
rs1431019467 1168 dbSNP
rs1346539073 1171 dbSNP
rs1057043125 1172 dbSNP
rs572132430 1173 dbSNP
rs3093698 1174 dbSNP
rs1176132615 1176 dbSNP
rs1045006674 1184 dbSNP
rs898289080 1186 dbSNP
rs995343261 1187 dbSNP
rs1187119582 1188 dbSNP
rs1025522039 1191 dbSNP
rs577821933 1192 dbSNP
rs1210398171 1198 dbSNP
rs1008007683 1208 dbSNP
rs782127863 1212 dbSNP
rs782149776 1215 dbSNP
rs1280711469 1223 dbSNP
rs1019260457 1234 dbSNP
rs963762493 1236 dbSNP
rs1294247688 1250 dbSNP
rs1214703941 1258 dbSNP
rs1363447687 1259 dbSNP
rs117117462 1275 dbSNP
rs1413767951 1281 dbSNP
rs3093699 1285 dbSNP
rs969412367 1294 dbSNP
rs1428390301 1306 dbSNP
rs575117439 1311 dbSNP
rs1171721055 1318 dbSNP
rs542637768 1323 dbSNP
rs1411689143 1326 dbSNP
rs1187524483 1328 dbSNP
rs1475632979 1332 dbSNP
rs554289921 1341 dbSNP
rs924807491 1350 dbSNP
rs1212682579 1358 dbSNP
rs1479527592 1362 dbSNP
rs1250756301 1369 dbSNP
rs1205099587 1374 dbSNP
rs938756432 1375 dbSNP
rs781907175 1394 dbSNP
rs915874338 1395 dbSNP
rs948751941 1396 dbSNP
rs1355629664 1403 dbSNP
rs1295519284 1404 dbSNP
rs1408449851 1405 dbSNP
rs1396223321 1409 dbSNP
rs1463934377 1414 dbSNP
rs78433288 1415 dbSNP
rs3093700 1424 dbSNP
rs1475665626 1429 dbSNP
rs1180280170 1430 dbSNP
rs1420369719 1430 dbSNP
rs1417122970 1437 dbSNP
rs898409174 1442 dbSNP
rs1249533627 1444 dbSNP
rs1481552915 1445 dbSNP
rs555354014 1445 dbSNP
rs1270734514 1450 dbSNP
rs1212463648 1460 dbSNP
rs1236397980 1470 dbSNP
rs1334908761 1470 dbSNP
rs782654735 1472 dbSNP
rs3093701 1474 dbSNP
rs3093702 1477 dbSNP
rs1393646509 1478 dbSNP
rs1366031534 1482 dbSNP
rs1325808233 1491 dbSNP
rs1462092351 1496 dbSNP
rs532387461 1498 dbSNP
rs577022458 1499 dbSNP
rs1157280124 1510 dbSNP
rs373050881 1514 dbSNP
rs782445381 1518 dbSNP
rs1363043180 1519 dbSNP
rs1159482005 1526 dbSNP
rs1420824606 1544 dbSNP
rs1251132381 1545 dbSNP
rs1192931469 1548 dbSNP
rs183965660 1549 dbSNP
rs1349419300 1551 dbSNP
rs545777961 1552 dbSNP
rs782364967 1556 dbSNP
rs3093703 1557 dbSNP
rs1442252668 1558 dbSNP
rs1373317952 1571 dbSNP
rs1316266574 1578 dbSNP
rs549321540 1580 dbSNP
rs1381868407 1595 dbSNP
rs1385871788 1597 dbSNP
rs141105720 1611 dbSNP
rs1455218310 1617 dbSNP
rs1393006773 1624 dbSNP
rs144787950 1630 dbSNP
rs1454628019 1639 dbSNP
rs1190321184 1645 dbSNP
rs1021751121 1646 dbSNP
rs1262072110 1647 dbSNP
rs1206496136 1649 dbSNP
rs1484923557 1651 dbSNP
rs1280001306 1655 dbSNP
rs555759609 1656 dbSNP
rs1350602353 1658 dbSNP
rs1268507508 1659 dbSNP
rs968980406 1661 dbSNP
rs1226867375 1668 dbSNP
rs80173960 1678 dbSNP
rs1320582930 1679 dbSNP
rs1413145518 1682 dbSNP
rs1435274328 1686 dbSNP
rs1031771843 1687 dbSNP
rs3093704 1691 dbSNP
rs992833333 1698 dbSNP
rs915989817 1703 dbSNP
rs1373130676 1705 dbSNP
rs1194906129 1707 dbSNP
rs1473999163 1708 dbSNP
rs1257265775 1709 dbSNP
rs1211974873 1710 dbSNP
rs185901624 1713 dbSNP
rs948856317 1715 dbSNP
rs1195702449 1738 dbSNP
rs3093705 1739 dbSNP
rs1271958221 1749 dbSNP
rs782503091 1755 dbSNP
rs920620537 1757 dbSNP
rs1354990247 1759 dbSNP
rs569505060 1763 dbSNP
rs1415235207 1767 dbSNP
rs3093706 1770 dbSNP
rs1326828062 1771 dbSNP
rs1409250983 1798 dbSNP
rs140301828 1807 dbSNP
rs1172109413 1816 dbSNP
rs943858070 1819 dbSNP
rs782679208 1821 dbSNP
rs1459561886 1823 dbSNP
rs1416793748 1835 dbSNP
rs572796896 1837 dbSNP
rs540319692 1840 dbSNP
rs997025398 1847 dbSNP
rs190822575 1849 dbSNP
rs781949628 1851 dbSNP
rs1275218542 1853 dbSNP
rs1211961474 1855 dbSNP
rs999041314 1858 dbSNP
rs751249872 1870 dbSNP
rs797035528 1875 dbSNP
rs1031887672 1879 dbSNP
rs960165031 1885 dbSNP
rs1381101525 1887 dbSNP
rs1277515716 1892 dbSNP
rs1014372454 1898 dbSNP
rs1023578842 1903 dbSNP
rs1336218694 1905 dbSNP
rs1333273229 1908 dbSNP
rs1438167242 1912 dbSNP
rs577087805 1919 dbSNP
rs1165261255 1930 dbSNP
rs1406696318 1933 dbSNP
rs1406285357 1935 dbSNP
rs1158292422 1937 dbSNP
rs1240642526 1938 dbSNP
rs1192269609 1943 dbSNP
rs1468129054 1958 dbSNP
rs970153381 1972 dbSNP
rs1215823079 1974 dbSNP
rs1315284444 1980 dbSNP
rs973908756 1981 dbSNP
rs1223062358 1983 dbSNP
rs1351129140 2005 dbSNP
rs1311426300 2019 dbSNP
rs544391362 2024 dbSNP
rs920580998 2031 dbSNP
rs1325951250 2032 dbSNP
rs1438183557 2034 dbSNP
rs562555076 2036 dbSNP
rs1343127564 2055 dbSNP
rs950696880 2061 dbSNP
rs982659988 2078 dbSNP
rs908449882 2087 dbSNP
rs1382532225 2101 dbSNP
rs1172338441 2108 dbSNP
rs1454188203 2113 dbSNP
rs561737573 2117 dbSNP
rs1192934393 2119 dbSNP
rs1484926669 2124 dbSNP
rs1241815794 2133 dbSNP
rs1447416921 2141 dbSNP
rs529957030 2142 dbSNP
rs879953557 2145 dbSNP
rs182494703 2148 dbSNP
rs541764554 2156 dbSNP
rs1220515679 2159 dbSNP
rs1359211100 2161 dbSNP
rs1269278171 2163 dbSNP
rs932392326 2164 dbSNP
rs1043217872 2168 dbSNP
rs1362878322 2175 dbSNP
rs904159817 2177 dbSNP
rs561334970 2179 dbSNP
rs528508896 2184 dbSNP
rs1311370460 2186 dbSNP
rs782395730 2187 dbSNP
rs998485185 2197 dbSNP
rs1376657106 2205 dbSNP
rs187185696 2206 dbSNP
rs1418870344 2209 dbSNP
rs60150286 2209 dbSNP
rs1052753548 2224 dbSNP
rs1478904554 2229 dbSNP
rs375960000 2230 dbSNP
rs3093707 2233 dbSNP
rs782016481 2235 dbSNP
rs1208530155 2237 dbSNP
rs1485217508 2244 dbSNP
rs571436398 2247 dbSNP
rs1212121139 2264 dbSNP
rs3093708 2266 dbSNP
rs3093709 2268 dbSNP
rs569362068 2271 dbSNP
rs970648062 2279 dbSNP
rs1214801301 2281 dbSNP
rs994890972 2282 dbSNP
rs1028159083 2296 dbSNP
rs1291043247 2299 dbSNP
rs950809070 2303 dbSNP
rs1414624557 2306 dbSNP
rs1356469418 2308 dbSNP
rs1305164212 2309 dbSNP
rs536948161 2313 dbSNP
rs1354046177 2316 dbSNP
rs911922306 2325 dbSNP
rs1467397549 2333 dbSNP
rs965277291 2334 dbSNP
rs150639318 2338 dbSNP
rs1474784579 2343 dbSNP
rs1256531706 2347 dbSNP
rs1183557488 2354 dbSNP
rs1479578639 2355 dbSNP
rs143481279 2357 dbSNP
rs1250280636 2358 dbSNP
rs977089587 2360 dbSNP
rs1319380902 2365 dbSNP
rs1270928971 2373 dbSNP
rs1232280614 2374 dbSNP
rs1322724642 2383 dbSNP
rs148004236 2396 dbSNP
rs1390176524 2398 dbSNP
rs1373173198 2400 dbSNP
rs533797536 2406 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aggguccuugguacuAUAGUGu 5'
                         |||||| 
Target 5' ----aauuuuuccuuUAUCACa 3'
 		1 - 18
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000226225.2 | 3UTR | AAUUUUUCCUUUAUCACAUAACUGUAAUAUUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
Click to see details
45 hsa-miR-3689a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT112230 MDM4 MDM4, p53 regulator 2 2
MIRT188656 FAM76A family with sequence similarity 76 member A 2 2
MIRT200911 ZNF264 zinc finger protein 264 2 4
MIRT210595 KBTBD8 kelch repeat and BTB domain containing 8 2 6
MIRT299207 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT317524 SLC39A7 solute carrier family 39 member 7 2 2
MIRT355849 SGMS2 sphingomyelin synthase 2 2 4
MIRT443052 THRB thyroid hormone receptor beta 2 2
MIRT446631 SDC3 syndecan 3 2 2
MIRT449409 TRIM5 tripartite motif containing 5 2 2
MIRT463561 ZBTB39 zinc finger and BTB domain containing 39 2 6
MIRT465704 TNFAIP1 TNF alpha induced protein 1 2 2
MIRT472688 MYCBP MYC binding protein 2 4
MIRT493287 LNPEP leucyl and cystinyl aminopeptidase 2 2
MIRT499338 RAB25 RAB25, member RAS oncogene family 2 2
MIRT501723 OVOL1 ovo like transcriptional repressor 1 2 2
MIRT507977 BCL2L13 BCL2 like 13 2 4
MIRT511811 HDGF heparin binding growth factor 2 6
MIRT516711 PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma 2 4
MIRT527853 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT531286 SLC7A7 solute carrier family 7 member 7 2 2
MIRT531894 INVS inversin 2 8
MIRT536807 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT537807 EFNB2 ephrin B2 2 4
MIRT544335 LPGAT1 lysophosphatidylglycerol acyltransferase 1 2 2
MIRT547142 PGM3 phosphoglucomutase 3 2 2
MIRT547429 MED4 mediator complex subunit 4 2 2
MIRT563354 ZNF181 zinc finger protein 181 2 2
MIRT564849 ZBED3 zinc finger BED-type containing 3 2 2
MIRT566426 PIGA phosphatidylinositol glycan anchor biosynthesis class A 2 2
MIRT572512 KIAA0232 KIAA0232 2 2
MIRT574682 HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 2 2
MIRT608820 ONECUT3 one cut homeobox 3 2 6
MIRT608886 CLIC6 chloride intracellular channel 6 2 2
MIRT608959 GIMAP1 GTPase, IMAP family member 1 2 4
MIRT609012 HPS3 HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 2 2
MIRT641431 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT661841 ZNF587B zinc finger protein 587B 2 2
MIRT690651 RPF2 ribosome production factor 2 homolog 2 2
MIRT704619 CLIP1 CAP-Gly domain containing linker protein 1 2 2
MIRT708714 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT710663 CSTF2T cleavage stimulation factor subunit 2 tau variant 2 2
MIRT711260 TPCN2 two pore segment channel 2 2 2
MIRT714649 FSTL1 follistatin like 1 2 2
MIRT718518 COL19A1 collagen type XIX alpha 1 chain 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3689a Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-miR-3689a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-3689a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-3689a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

Error report submission