miRTarBase - #MIRT465871


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pre-miRNA Information
pre-miRNA hsa-mir-6737   
Genomic Coordinates chr1: 153962351 - 153962420
Description Homo sapiens miR-6737 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6737-5p
Sequence 6| UUGGGGUGGUCGGCCCUGGAG |26
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs766338599 4 dbSNP
rs765728788 7 dbSNP
rs757341439 9 dbSNP
rs539511149 11 dbSNP
rs764259486 12 dbSNP
rs988937601 21 dbSNP
Putative Targets

Gene Information
Gene Symbol TMEM43   
Synonyms ARVC5, ARVD5, EDMD7, LUMA
Description transmembrane protein 43
Transcript NM_024334   
Expression
Putative miRNA Targets on TMEM43
3'UTR of TMEM43
(miRNA target sites are highlighted)		 
>TMEM43|NM_024334|3'UTR
   1 AAAGACCCTGGCACCCGCCCGACACCTGCGTGAGCCCTAGGATCCAGGTCCTCTCTCACCTCTGACCCAGCTCCATGCCA
  81 GAGCAGGAGCCCCGGTCAATTTTGGACTCTGCACTCCCTCTCCTCTTCAGGGGCCAGACTTGGCAGCATGTGCACCAGGT
 161 TGGTGTTCACCAGCTCATGTCTTCCCCACATCTCTTCTTGCCAGTAAGCAGCTTTGGTGGGCAGCAGCAGCTCATGAATG
 241 GCAAGCTGACAGCTTCTCCTGCTGTTTCCTTCCTCTCTTGGACTGAGTGGGTACGGCCAGCCACTCAGCCCATTGGCAGC
 321 TGACAACGCAGACACGCTCTACGGAGGCCTGCTGATAAAGGGCTCAGCCTTGCCGTGTGCTGCTTCTCATCACTGCACAC
 401 AAGTGCCATGCTTTGCCACCACCACCAAGCACATCTGTGATCCTGAAGGGCGGCCGTTAGTCATTACTGCTGAGTCCTGG
 481 GTCACCAGCAGACACACTGGGCATGGACCCCTCAAAGCAGGCACACCCAAAACACAAGTCTGTGGCTAGAACCTGATGTG
 561 GTGTTTAAAAGAGAAGAAACACTGAAGATGTCCTGAGGAGAAAAGCTGGACATATACTGGGCTTCACACTTATCTTATGG
 641 CTTGGCAGAATCTTTGTAGTGTGTGGGATCTCTGAAGGCCCTATTTAAGTTTTTCTTCGTTACTTTGCTGCTTCATGTGT
 721 ACTTTCCTACCCCAAGAGGAAGTTTTCTGAAATAAGATTTAAAAACAAAACAAAAAAAACACTTAATATTTCAGACTGTT
 801 ACAGGAAACACCCTTTAGTCTGTCAGTTGAATTCAGAGCACTGAAAGGTGTTAAATTGGGGTATGTGGTTTGATTGATAA
 881 AAAGTTACCTCTCAGTATTTTGTGTCACTGAGAAGCTTTACAATGGATGCTTTTGAAACAAGTATCAGCAAAAGGATTTG
 961 TTTTCACTCTGGGAGGAGAGGGTGGAGAAAGCACTTGCTTTCATCCTCTGGCATCGGAAACTCCCCTATGCACTTGAAGA
1041 TGGTTTAAAAGATTAAAGAAACGATTAAGAGAAAAGGTTGGAAGCTTTATACTAAATGGGCTCCTTCATGGTGACGCCCC
1121 GTCAACCACAATCAAGAACTGAGGCCTGAGGCTGGTTGTACAATGCCCACGCCTGCCTGGCTGCTTTCACCTGGGAGTGC
1201 TTTCGATGTGGGCACCTGGGCTTCCTAGGGCTGCTTCTGAGTGGTTCTTTCACGTGTTGTGTCCATAGCTTTAGTCTTCC
1281 TAAATAAGATCCACCCACACCTAAGTCACAGAATTTCTAAGTTCCCCAACTACTCTCACACCCTTTTAAAGATAAAGTAT
1361 GTTGTAACCAGGATGTCTTAAATGATTCTTTGTGTACCTTTTCTGTCATATTCAGAAACCGTTTTGTGCCTGCTGGGAGT
1441 AATTCCTTTAGCAATTAAGTATTTGGTAGCTGAATAAGGGGTCAGAACTTCTGAAACCAGAGATCTGTAATCATCTCTAT
1521 TGGCCTGGGGTGCCTGTGCTATAAATGAGTTTCTTCACATGAAAAACACAGCCAGCCCAAGATGACTTATCTGGGTTTAG
1601 GATTCAATAGTATTCACTAACTGCTTATTACATGAGCAATTTCATCAAATCTCCAAACTCTTAAAGGATGCTTTCGGAAA
1681 ACACGCTGTATACCTAGATGATGACTAAATGCAAAATCCTTGGGCTTTGGTTTTTTTCTAGTAAGGATTTTAAATAACTG
1761 CCGACTTCAAAAGTGTTCTTAAAACGAAAGATAATGTTAAGAAAAATTTGAAAGCTTTGGAAAACCAAATTTGTAATATC
1841 ATTGTATTTTTTATTAAAAGTTTTGTAATAAATTTCTAAATTATCA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaggucccggcuGGUGGGGUu 5'
                      |:|||||| 
Target 5' atgtgtactttcCTACCCCAa 3'
 715 - 735 129.00 -14.20
2 
miRNA  3' gaGGUCC----CGGCUGGUGG-GGUu 5'
            ||| |    ||| |||||| ||| 
Target 5' tgCCATGCTTTGCC-ACCACCACCAa 3'
 404 - 428 128.00 -20.50
3 
miRNA  3' gaGGUCCCGGCUGGUGGGGUu 5'
            |||  |||  :|| |||| 
Target 5' ggCCA--GCCACTCAGCCCAt 3'
 295 - 313 123.00 -17.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
46136 9 ClinVar
188665 17 ClinVar
386774 21 ClinVar
343511 116 ClinVar
343512 218 ClinVar
343514 271 ClinVar
343515 278 ClinVar
343516 313 ClinVar
343518 464 ClinVar
343520 720 ClinVar
343522 762 ClinVar
343523 780 ClinVar
343524 807 ClinVar
343525 850 ClinVar
343527 925 ClinVar
343529 1054 ClinVar
343530 1081 ClinVar
343532 1161 ClinVar
343533 1162 ClinVar
343534 1347 ClinVar
343535 1375 ClinVar
343536 1425 ClinVar
343538 1536 ClinVar
343539 1585 ClinVar
343540 1643 ClinVar
343541 1676 ClinVar
343542 1701 ClinVar
COSN31526586 34 COSMIC
COSN31559965 48 COSMIC
COSN31488872 585 COSMIC
COSN28432427 616 COSMIC
COSN31962022 657 COSMIC
COSN30176762 690 COSMIC
COSN31527478 699 COSMIC
COSN26646291 767 COSMIC
COSN20098127 772 COSMIC
COSN28771815 780 COSMIC
COSN31526842 780 COSMIC
COSN27642391 814 COSMIC
COSN25121317 1087 COSMIC
COSN1268833 1136 COSMIC
COSN9132256 1421 COSMIC
COSN1917568 1717 COSMIC
COSN16323973 1790 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1439417387 5 dbSNP
rs192707412 9 dbSNP
rs1245864271 15 dbSNP
rs3796310 17 dbSNP
rs979264625 18 dbSNP
rs1048911431 19 dbSNP
rs770828455 20 dbSNP
rs369461997 21 dbSNP
rs745658635 22 dbSNP
rs373515736 25 dbSNP
rs536469258 30 dbSNP
rs760768474 31 dbSNP
rs182728261 32 dbSNP
rs780991894 37 dbSNP
rs776622211 39 dbSNP
rs1330931103 47 dbSNP
rs1442064745 48 dbSNP
rs1443024499 51 dbSNP
rs911879585 51 dbSNP
rs761950095 52 dbSNP
rs1244674448 55 dbSNP
rs1184041938 56 dbSNP
rs966031012 65 dbSNP
rs757029755 92 dbSNP
rs886058031 94 dbSNP
rs574077213 95 dbSNP
rs1467201452 100 dbSNP
rs1339422757 105 dbSNP
rs1295478411 113 dbSNP
rs1043943 116 dbSNP
rs979984018 117 dbSNP
rs1317610464 118 dbSNP
rs925485560 119 dbSNP
rs1335666138 123 dbSNP
rs1039594389 124 dbSNP
rs1327485128 125 dbSNP
rs1308213587 133 dbSNP
rs1354334625 138 dbSNP
rs1225337069 140 dbSNP
rs1397243903 149 dbSNP
rs1302631884 151 dbSNP
rs959858182 157 dbSNP
rs188887911 167 dbSNP
rs1287212014 173 dbSNP
rs1450505926 180 dbSNP
rs528602745 181 dbSNP
rs991092070 186 dbSNP
rs1221909207 193 dbSNP
rs1469472121 202 dbSNP
rs3814414 205 dbSNP
rs1183835926 209 dbSNP
rs1438343489 213 dbSNP
rs116757981 218 dbSNP
rs1045402860 236 dbSNP
rs750648759 240 dbSNP
rs756414351 243 dbSNP
rs1292115844 246 dbSNP
rs756181039 247 dbSNP
rs886886094 255 dbSNP
rs1278169283 256 dbSNP
rs779705262 258 dbSNP
rs1241720083 259 dbSNP
rs533189312 263 dbSNP
rs1302612102 269 dbSNP
rs886058032 271 dbSNP
rs1403232997 273 dbSNP
rs754755163 276 dbSNP
rs1303942828 277 dbSNP
rs11943 278 dbSNP
rs1413221030 280 dbSNP
rs1406008362 282 dbSNP
rs895479083 287 dbSNP
rs1196625366 289 dbSNP
rs1166945020 291 dbSNP
rs1269014793 294 dbSNP
rs1013175320 295 dbSNP
rs1023185006 296 dbSNP
rs569662640 297 dbSNP
rs1446235381 298 dbSNP
rs1207320267 302 dbSNP
rs1330401175 303 dbSNP
rs1283251256 304 dbSNP
rs11920099 313 dbSNP
rs142596143 314 dbSNP
rs565407824 326 dbSNP
rs534434288 328 dbSNP
rs956153715 329 dbSNP
rs748127702 336 dbSNP
rs987509493 338 dbSNP
rs1228425024 340 dbSNP
rs1274429846 342 dbSNP
rs558776660 343 dbSNP
rs997497536 344 dbSNP
rs777323551 349 dbSNP
rs1197603074 356 dbSNP
rs1470929930 357 dbSNP
rs1020983876 361 dbSNP
rs902569400 362 dbSNP
rs777881444 364 dbSNP
rs1474213383 366 dbSNP
rs370514707 375 dbSNP
rs577174408 376 dbSNP
rs1032887119 378 dbSNP
rs557868412 382 dbSNP
rs1186115123 384 dbSNP
rs964644403 386 dbSNP
rs1326282285 391 dbSNP
rs1279422483 400 dbSNP
rs578094273 404 dbSNP
rs1214121362 410 dbSNP
rs537694549 422 dbSNP
rs975748705 423 dbSNP
rs959566021 428 dbSNP
rs1436131384 431 dbSNP
rs146632885 434 dbSNP
rs931205078 446 dbSNP
rs1406809144 447 dbSNP
rs1025169453 452 dbSNP
rs1465353875 453 dbSNP
rs908362316 455 dbSNP
rs970977670 456 dbSNP
rs1056861118 457 dbSNP
rs1171646750 458 dbSNP
rs1463041987 459 dbSNP
rs1400826533 461 dbSNP
rs1043953 464 dbSNP
rs553320712 472 dbSNP
rs1012559900 481 dbSNP
rs1045064381 485 dbSNP
rs1229342251 497 dbSNP
rs918936499 502 dbSNP
rs929008625 510 dbSNP
rs530754344 512 dbSNP
rs1312626227 516 dbSNP
rs1247959947 519 dbSNP
rs904799906 526 dbSNP
rs1297497494 529 dbSNP
rs1000842802 534 dbSNP
rs1355710469 548 dbSNP
rs984554594 549 dbSNP
rs1423598810 550 dbSNP
rs1383065109 553 dbSNP
rs777188170 558 dbSNP
rs184223182 561 dbSNP
rs1415021841 577 dbSNP
rs891963471 590 dbSNP
rs1479951946 593 dbSNP
rs943202839 611 dbSNP
rs1018955580 613 dbSNP
rs1490241083 618 dbSNP
rs1248482763 629 dbSNP
rs1258283053 629 dbSNP
rs1322048284 633 dbSNP
rs1293098497 634 dbSNP
rs1038907588 638 dbSNP
rs1340981955 639 dbSNP
rs1199129916 640 dbSNP
rs200458930 645 dbSNP
rs1403856227 646 dbSNP
rs901735925 655 dbSNP
rs559809675 657 dbSNP
rs1042375712 661 dbSNP
rs902516358 667 dbSNP
rs1001315430 681 dbSNP
rs1261209472 684 dbSNP
rs1350772462 685 dbSNP
rs1158842885 686 dbSNP
rs1477523724 686 dbSNP
rs1414896640 687 dbSNP
rs1182947671 688 dbSNP
rs1194415107 690 dbSNP
rs1266891659 690 dbSNP
rs1426085198 693 dbSNP
rs573343290 699 dbSNP
rs1488930048 700 dbSNP
rs545159709 708 dbSNP
rs1213450742 710 dbSNP
rs1318636284 714 dbSNP
rs1268740795 715 dbSNP
rs1222864391 718 dbSNP
rs3796308 720 dbSNP
rs1284658779 724 dbSNP
rs1386925649 726 dbSNP
rs1012398742 727 dbSNP
rs908376405 737 dbSNP
rs886058033 739 dbSNP
rs777066143 745 dbSNP
rs1452133490 757 dbSNP
rs1391325339 761 dbSNP
rs1160490817 762 dbSNP
rs141474582 762 dbSNP
rs1025117339 766 dbSNP
rs939799806 766 dbSNP
rs1415033799 767 dbSNP
rs760030477 769 dbSNP
rs1184531239 772 dbSNP
rs1433966148 772 dbSNP
rs200103198 772 dbSNP
rs1486702627 777 dbSNP
rs1314608720 779 dbSNP
rs13069 780 dbSNP
rs972967706 781 dbSNP
rs1025891524 783 dbSNP
rs1233418123 783 dbSNP
rs1398876504 784 dbSNP
rs1278236936 790 dbSNP
rs950405305 791 dbSNP
rs1383583128 795 dbSNP
rs549990365 800 dbSNP
rs2731310 801 dbSNP
rs2731309 802 dbSNP
rs563202644 803 dbSNP
rs984891220 804 dbSNP
rs908942505 805 dbSNP
rs1404607540 806 dbSNP
rs1174366365 807 dbSNP
rs58476065 807 dbSNP
rs1346146118 808 dbSNP
rs763227004 811 dbSNP
rs1168545613 816 dbSNP
rs1451579049 817 dbSNP
rs141247533 819 dbSNP
rs1213693308 822 dbSNP
rs1284530381 823 dbSNP
rs1488226038 836 dbSNP
rs1217439781 839 dbSNP
rs1201849577 848 dbSNP
rs886058034 850 dbSNP
rs145011666 851 dbSNP
rs933187146 853 dbSNP
rs1019052011 857 dbSNP
rs188883174 862 dbSNP
rs1298775346 866 dbSNP
rs1245759470 867 dbSNP
rs551182461 868 dbSNP
rs1336678482 870 dbSNP
rs2731308 880 dbSNP
rs148290121 886 dbSNP
rs80058578 893 dbSNP
rs1027692953 894 dbSNP
rs895209093 896 dbSNP
rs1391082295 898 dbSNP
rs984060762 901 dbSNP
rs1442502687 910 dbSNP
rs1175232827 916 dbSNP
rs1369999042 919 dbSNP
rs1012299872 923 dbSNP
rs1188098092 923 dbSNP
rs557589455 924 dbSNP
rs79741000 925 dbSNP
rs1418953708 929 dbSNP
rs992686416 931 dbSNP
rs536962928 939 dbSNP
rs1298292517 940 dbSNP
rs553740010 941 dbSNP
rs1290628628 959 dbSNP
rs948532072 961 dbSNP
rs761608776 962 dbSNP
rs1246088946 965 dbSNP
rs1335756519 968 dbSNP
rs1304943189 979 dbSNP
rs776163428 986 dbSNP
rs994329114 993 dbSNP
rs57116017 995 dbSNP
rs980257199 998 dbSNP
rs1025880962 1008 dbSNP
rs573135235 1009 dbSNP
rs1302728261 1013 dbSNP
rs192216287 1016 dbSNP
rs1005860010 1017 dbSNP
rs1331275453 1020 dbSNP
rs1236997801 1021 dbSNP
rs58199833 1029 dbSNP
rs1362037546 1033 dbSNP
rs1353637198 1049 dbSNP
rs550702296 1054 dbSNP
rs964456126 1063 dbSNP
rs974490135 1064 dbSNP
rs766676379 1067 dbSNP
rs183980178 1070 dbSNP
rs954522263 1073 dbSNP
rs568225509 1078 dbSNP
rs867349396 1079 dbSNP
rs886058035 1081 dbSNP
rs189766472 1087 dbSNP
rs977950104 1108 dbSNP
rs944946969 1109 dbSNP
rs1230795337 1111 dbSNP
rs373956484 1116 dbSNP
rs1236075531 1117 dbSNP
rs936603971 1118 dbSNP
rs180722159 1121 dbSNP
rs916576123 1122 dbSNP
rs767404829 1123 dbSNP
rs1427909020 1124 dbSNP
rs1173721309 1131 dbSNP
rs1478801102 1132 dbSNP
rs887796236 1140 dbSNP
rs559269403 1146 dbSNP
rs1446747303 1148 dbSNP
rs1246585864 1150 dbSNP
rs1005271221 1152 dbSNP
rs9842062 1161 dbSNP
rs886058036 1162 dbSNP
rs1162083585 1171 dbSNP
rs1262570543 1172 dbSNP
rs906655969 1174 dbSNP
rs1347357408 1177 dbSNP
rs994276596 1190 dbSNP
rs36114542 1193 dbSNP
rs1442577108 1199 dbSNP
rs1329799746 1205 dbSNP
rs1047694196 1206 dbSNP
rs1014175478 1216 dbSNP
rs1448214855 1221 dbSNP
rs1024184759 1224 dbSNP
rs888675077 1225 dbSNP
rs1405336761 1232 dbSNP
rs1006223432 1235 dbSNP
rs1320398107 1236 dbSNP
rs979885003 1244 dbSNP
rs1244202513 1245 dbSNP
rs1166896715 1251 dbSNP
rs925666760 1254 dbSNP
rs1015890176 1255 dbSNP
rs964369683 1257 dbSNP
rs957124332 1259 dbSNP
rs1266042923 1263 dbSNP
rs551362540 1267 dbSNP
rs988464005 1270 dbSNP
rs995878965 1273 dbSNP
rs1279440298 1276 dbSNP
rs1214137698 1277 dbSNP
rs1030074370 1283 dbSNP
rs750313568 1291 dbSNP
rs1228939998 1299 dbSNP
rs558428746 1304 dbSNP
rs977896305 1309 dbSNP
rs1300973492 1314 dbSNP
rs1450156105 1318 dbSNP
rs1040562950 1319 dbSNP
rs1186450137 1323 dbSNP
rs922130072 1327 dbSNP
rs923784672 1328 dbSNP
rs1252617529 1334 dbSNP
rs932112698 1336 dbSNP
rs957946546 1339 dbSNP
rs1450433765 1340 dbSNP
rs1049166260 1341 dbSNP
rs1474063426 1344 dbSNP
rs71699966 1347 dbSNP
rs886058037 1347 dbSNP
rs1186239070 1349 dbSNP
rs887884353 1354 dbSNP
rs1482184340 1355 dbSNP
rs756092859 1365 dbSNP
rs780193027 1369 dbSNP
rs1358406913 1370 dbSNP
rs8516 1375 dbSNP
rs1014183825 1379 dbSNP
rs1046404027 1385 dbSNP
rs1379875832 1386 dbSNP
rs762458156 1391 dbSNP
rs1278418882 1392 dbSNP
rs1407500219 1406 dbSNP
rs1371901263 1408 dbSNP
rs1024196047 1409 dbSNP
rs1400085473 1411 dbSNP
rs1349595035 1412 dbSNP
rs758440005 1421 dbSNP
rs10468 1425 dbSNP
rs747210370 1427 dbSNP
rs1176664625 1430 dbSNP
rs1300225536 1444 dbSNP
rs1471630133 1449 dbSNP
rs1254103035 1450 dbSNP
rs1377632359 1450 dbSNP
rs930073665 1452 dbSNP
rs185974653 1453 dbSNP
rs1001796845 1455 dbSNP
rs1357443249 1456 dbSNP
rs1283423112 1466 dbSNP
rs1032831807 1475 dbSNP
rs1351735311 1476 dbSNP
rs1288431779 1489 dbSNP
rs1403950062 1490 dbSNP
rs1365122543 1493 dbSNP
rs567845799 1497 dbSNP
rs1439100981 1498 dbSNP
rs1350869038 1499 dbSNP
rs1159018231 1503 dbSNP
rs957382737 1506 dbSNP
rs1414194338 1510 dbSNP
rs1257639648 1513 dbSNP
rs771207962 1518 dbSNP
rs1318814875 1520 dbSNP
rs79398164 1521 dbSNP
rs1252789810 1531 dbSNP
rs886058038 1536 dbSNP
rs1265581078 1537 dbSNP
rs1040354834 1543 dbSNP
rs1193174861 1545 dbSNP
rs900116568 1560 dbSNP
rs1241317091 1566 dbSNP
rs965647006 1574 dbSNP
rs995825251 1583 dbSNP
rs886058039 1585 dbSNP
rs1199797301 1592 dbSNP
rs1030022091 1595 dbSNP
rs890181520 1597 dbSNP
rs867552360 1599 dbSNP
rs781502716 1608 dbSNP
rs1302908447 1614 dbSNP
rs1387020019 1619 dbSNP
rs750593655 1619 dbSNP
rs1368680238 1620 dbSNP
rs1320316497 1629 dbSNP
rs553703056 1633 dbSNP
rs1422517657 1639 dbSNP
rs886058040 1643 dbSNP
rs9970 1644 dbSNP
rs958108028 1646 dbSNP
rs1391529051 1647 dbSNP
rs989356922 1657 dbSNP
rs922152678 1658 dbSNP
rs932235423 1662 dbSNP
rs1178432123 1667 dbSNP
rs1345279916 1676 dbSNP
rs1466037782 1676 dbSNP
rs886058041 1676 dbSNP
rs138060213 1677 dbSNP
rs1377408309 1678 dbSNP
rs1023488794 1685 dbSNP
rs969294855 1690 dbSNP
rs1466183268 1695 dbSNP
rs982049762 1698 dbSNP
rs1277572295 1699 dbSNP
rs886058042 1701 dbSNP
rs1248610889 1703 dbSNP
rs1481963357 1713 dbSNP
rs1362934437 1719 dbSNP
rs1216534551 1721 dbSNP
rs1297290972 1731 dbSNP
rs1297539820 1731 dbSNP
rs1310181544 1733 dbSNP
rs1367829764 1734 dbSNP
rs1298924564 1738 dbSNP
rs909376158 1745 dbSNP
rs927974716 1756 dbSNP
rs1400071190 1763 dbSNP
rs529838150 1764 dbSNP
rs940796338 1766 dbSNP
rs983267232 1769 dbSNP
rs746279849 1771 dbSNP
rs1451056964 1774 dbSNP
rs1390587870 1775 dbSNP
rs896496617 1781 dbSNP
rs538615521 1786 dbSNP
rs1039899210 1787 dbSNP
rs1200580914 1787 dbSNP
rs1482505126 1789 dbSNP
rs1213836175 1791 dbSNP
rs1261766967 1792 dbSNP
rs1344685559 1793 dbSNP
rs905803294 1799 dbSNP
rs558915075 1802 dbSNP
rs1298803165 1803 dbSNP
rs1187904235 1807 dbSNP
rs190531956 1810 dbSNP
rs1432944534 1816 dbSNP
rs1174604569 1832 dbSNP
rs934245066 1834 dbSNP
rs1314914173 1836 dbSNP
rs143620402 1837 dbSNP
rs1349985367 1843 dbSNP
rs1306356303 1846 dbSNP
rs1297720044 1847 dbSNP
rs775889525 1857 dbSNP
rs999240837 1858 dbSNP
rs1162507142 1866 dbSNP
rs1456320142 1867 dbSNP
rs886058043 1868 dbSNP
rs886058044 1885 dbSNP
rs1471948178 1886 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 79188.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gaGGUCCCGGCUGGUGGGGUu 5'
            |||   |:|  ||||||| 
Target 5' caCCA---CUG--CACCCCAg 3'
 		5 - 20
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gaGGUCCCGGCUGGUGGGGUu 5'
            |||   |:|  ||||||| 
Target 5' caCCA---CUG--CACCCCAg 3'
 		5 - 20
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000306077.4 | 3UTR | AUCACACCACUGCACCCCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000306077.4 | 3UTR | AUCACACCACUGCACCCCAGCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
67 hsa-miR-6737-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066215 MARCH9 membrane associated ring-CH-type finger 9 2 2
MIRT074413 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT125300 MID1IP1 MID1 interacting protein 1 2 2
MIRT153951 NCOA3 nuclear receptor coactivator 3 2 2
MIRT452776 FAM136A family with sequence similarity 136 member A 2 2
MIRT452977 CABP4 calcium binding protein 4 2 2
MIRT454128 FOXRED2 FAD dependent oxidoreductase domain containing 2 2 2
MIRT455242 DDX39B DExD-box helicase 39B 2 10
MIRT459007 UQCRH ubiquinol-cytochrome c reductase hinge protein 2 2
MIRT459463 MUC17 mucin 17, cell surface associated 2 4
MIRT460871 UBE2S ubiquitin conjugating enzyme E2 S 2 2
MIRT461264 COX10 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 2 2
MIRT464540 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT465268 TRIM28 tripartite motif containing 28 2 2
MIRT465871 TMEM43 transmembrane protein 43 2 4
MIRT466228 TMED10 transmembrane p24 trafficking protein 10 2 2
MIRT468417 SETD1B SET domain containing 1B 2 2
MIRT468684 SEC22C SEC22 homolog C, vesicle trafficking protein 2 4
MIRT473399 MDM4 MDM4, p53 regulator 2 2
MIRT473517 MAX MYC associated factor X 2 2
MIRT474511 KLHDC8A kelch domain containing 8A 2 2
MIRT475801 HDGF heparin binding growth factor 2 2
MIRT479493 CDH6 cadherin 6 2 2
MIRT480770 BMP2 bone morphogenetic protein 2 2 2
MIRT481418 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT482966 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT483380 SPATA6 spermatogenesis associated 6 2 4
MIRT483677 CYP11A1 cytochrome P450 family 11 subfamily A member 1 2 2
MIRT484328 EPN1 epsin 1 2 4
MIRT484963 UCK1 uridine-cytidine kinase 1 2 2
MIRT485908 PGPEP1 pyroglutamyl-peptidase I 2 4
MIRT488149 PRRC2B proline rich coiled-coil 2B 2 4
MIRT488943 CYP2W1 cytochrome P450 family 2 subfamily W member 1 2 6
MIRT491835 ZBTB7A zinc finger and BTB domain containing 7A 2 4
MIRT493026 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT499374 PLCG2 phospholipase C gamma 2 2 11
MIRT499723 USH1G USH1 protein network component sans 2 4
MIRT500349 ZNF385A zinc finger protein 385A 2 2
MIRT509574 HIST2H2AB histone cluster 2 H2A family member b 2 4
MIRT512794 GLRX glutaredoxin 2 2
MIRT513291 SETBP1 SET binding protein 1 2 2
MIRT515697 ZNF321P zinc finger protein 321, pseudogene 2 2
MIRT518255 LEAP2 liver enriched antimicrobial peptide 2 2 2
MIRT522026 PAQR3 progestin and adipoQ receptor family member 3 2 4
MIRT523169 HIST3H3 histone cluster 3 H3 2 2
MIRT524036 DNAJC8 DnaJ heat shock protein family (Hsp40) member C8 2 2
MIRT533476 TRIM71 tripartite motif containing 71 2 2
MIRT541488 ADM adrenomedullin 2 2
MIRT553987 SRPR SRP receptor alpha subunit 2 2
MIRT571445 YKT6 YKT6 v-SNARE homolog 2 2
MIRT574889 Plcg2 phospholipase C, gamma 2 2 7
MIRT607544 GLI2 GLI family zinc finger 2 2 2
MIRT607688 MAPK10 mitogen-activated protein kinase 10 2 2
MIRT610072 CRLF1 cytokine receptor like factor 1 2 2
MIRT610573 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT614041 THBS2 thrombospondin 2 2 2
MIRT626318 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT634005 RIF1 replication timing regulatory factor 1 2 2
MIRT639619 FGF19 fibroblast growth factor 19 2 2
MIRT647343 RPH3AL rabphilin 3A like (without C2 domains) 2 2
MIRT689704 ATXN2 ataxin 2 2 2
MIRT691170 APOL6 apolipoprotein L6 2 2
MIRT693165 NPR1 natriuretic peptide receptor 1 2 2
MIRT711727 NUPL2 nucleoporin like 2 2 2
MIRT711806 ELN elastin 2 2
MIRT721546 FXN frataxin 2 2
MIRT722979 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6737 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-6737 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-6737-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6737-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-6737-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-6737-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-6737-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-6737-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-6737-5p Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

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