miRTarBase - #MIRT466169


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pre-miRNA Information
pre-miRNA hsa-mir-664a   
Genomic Coordinates chr1: 220200538 - 220200619
Description Homo sapiens miR-664 stem-loop
Comment This miRNA sequence overlaps an annotated snoRNA, ACA38b. However, both miR and miR* sequences are identified in reference , and the sequence is homologous with rat mir-664.
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-664a-3p
Sequence 49| UAUUCAUUUAUCCCCAGCCUACA |71
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30457627 12 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1478242335 2 dbSNP
rs1042905485 5 dbSNP
rs908858734 6 dbSNP
rs1229753248 8 dbSNP
rs770101636 12 dbSNP
rs746047168 14 dbSNP
rs1170225715 15 dbSNP
rs1404740911 16 dbSNP
rs1393962832 17 dbSNP
rs1377901643 18 dbSNP
rs1313271494 19 dbSNP
rs1416447585 20 dbSNP
rs1368463251 21 dbSNP
rs1167925254 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TMED5   
Synonyms CGI-100, p24g2, p28
Description transmembrane p24 trafficking protein 5
Transcript NM_001167830   
Other Transcripts NM_016040   
Expression
Putative miRNA Targets on TMED5
3'UTR of TMED5
(miRNA target sites are highlighted)		 
>TMED5|NM_001167830|3'UTR
   1 AGCATTTGAAGCTCGTGATCGAAACATACAAGAAAGCAACTTTGATAGAGTCAATTTCTGGTCTATGGTTAATTTAGTGG
  81 TCATGGTGGTGGTGTCAGCCATTCAAGTTTATATGCTGAAGAGTCTGTTTGAAGATAAGAGGAAAAGTAGAACTTAAAAC
 161 TCCAAACTAGAGTACGTAACATTGAAAAATGAGGCATAAAAATGCAATAAACTGTTACAGTCAAGACCATTAATGGTCTT
 241 CTCCAAAATATTTTGAGATATAAAAGTAGGAAACAGGTATAATTTTAATGTGAAAATTAAGTCTTCACTTTCTGTGCAAG
 321 TAATCCTGCTGATCCAGTTGTACTTAAGTGTGTAACAGGAATATTTTGCAGAATATAGGTTTAACTGAATGAAGCCATAT
 401 TAATAACTGCATTTTCCTAACTTTGAAAAATTTTGCAAATGTCTTAGGTGATTTAAATAAATGAGTATTGGGCCTAATTG
 481 CAACACCAGTCTGTTTTTAACAGGTTCTATTACCCAGAACTTTTTTGTAAATGCGGCAGTTACAAATTAACTGTGGAAGT
 561 TTTCAGTTTTAAGTTATAAATCACCTGAGAATTACCTAATGATGGATTGAATAAATCTTTAGACTACAAAAGCCCAACTT
 641 TTCTCTATTTACATATGCATCTCTCCTATAATGTAAATAGAATAATAGCTTTGAAATACAATTAGGTTTTTGAGATTTTT
 721 ATAACCAAATACATTTCAGTGTAACATATTAGCAGAAAGCATTAGTCTTTGTACTTTGCTTACATTCCCAAAAGCTGACA
 801 TTTTCACGATTCTTAAAAACACAAAGTTACACTTACTAAAATTAGGACATGTTTTCTCTTTGAAATGAAGAATATAGTTT
 881 AAAAGCTTCCTCCTCCATAGGGACACATTTTCTCTAACCCTTAACTAAAGTGTAGGATTTTAAAATTAAATGTGAGGTAA
 961 AATAAGTTTATTTTTAATAGTATCTGTCAAGTTAATATCTGTCAACAGTTAATAATCATGTTATGTTAATTTTAACATGA
1041 TTGCTGACTTGGATAATTCATTATTACCAGCAGTTATGAAGGAAATATTGCTAAAATGATCTGGGCCTACCATAAATAAA
1121 TATCTCCTTTTCTGAGCTCTAAGAATTATCAGAAACAGGAAAGAATTTAGAAAAACTTGAGAAAACCTAATCCAAAATAA
1201 AATTCACTTAAGTAGAACTATAAATAAATATCTAGAATCTGACTGGCTCATCATGACATCCTACTCATAACATAAATCAA
1281 AGGAGATGATTAATTTCCAGTTAGCTGGAAGAAACTTTGGCTGTAGGTTTTTATTTTCTACAAGAATTCTGGTTTGAATT
1361 ATTTTTGTAAGCAGGTACATTTTATAAAATGTAAGCCCTACTGTAAGGTTTAGCACTGGGTGTACATATTTATTAAAAAT
1441 TTTTATTATAACAACTTTTATTAAAATGGCCTTTCTGAACACTTTATTTATTGATGTTGAAGTAAGGATTAGAAACATAG
1521 ACTCCCAAGTTTTAAACACCTAAATGTGAATAACCCATATATACAACAAAGTTTCTGCCATCTAGCTTTTTGAAGTCTAT
1601 GGGGGTCTTACTCAAGTACTAGTAATTTAACTTCATCATGAATGAACTATAATTTTTAAGTTATGCCCATTTATAACGTT
1681 GTTTATGACTACATTGTGAGTTAGAAACAAACTTAAAATTTGGGGTATAGAACCCCTCAACAGGTTAGTAATGCTGGAAT
1761 TCTTGATGAGCAATAATGATAACCAGAGAGTGATTTCATTTACACTCATAGTAGTATAAAAAGAGATACATTTCCCTCTT
1841 AGGCCCCTGGGAGAAGAGCAGCTTAGATTTCCCTACTGGCAAGGTTTTTAAAAATGAGGTAAATGCCGTATATGATCAAT
1921 TACCTTAATTGGCCAAGAAAATGCTTCAGGTGTCTAGGGGTATCCTCTGCAACACTTGCAGAACAAAGGTCAATAAGATC
2001 CTTGCCTATGAATACCCCTCCCTTTTGCGCTGTTAAATTTGCAATGAGAAGCAAATTTACAGTACCATAACTAATAAAGC
2081 AGGGTACAGATATAAACTACTGCATCTTTTCTATAAAACTGTGATTAAGAATTCTACCTCTCCTGTATGGCTGTTACTGT
2161 ACTGTACTCTCTGACTCCTTACCTAACAATGAATTTGTTACATAATCTTCTACATGTATGATTTGTGCCACTGATCTTAA
2241 ACCTATGATTCAGTAACTTCTTACCATATAAAAACGATAATTGCTTTATTTGGAAAAGAATTTAGGAATACTAAGGACAA
2321 TTATTTTTATAGACAAAGTAAAAAGACAGATATTTAAGAGGCATAACCAAAAAAGCAAAACTTGTAAACAGAGTAAAAAT
2401 CTTTAATATTTCTAAAGACATACTGTTTATCTGCTTCATATGCTTTTTTTAATTTCACTATTCCATTTCTAAATTAAAGT
2481 TATGCTAAATTGAGTAAGCTGTTTATCACTTAACAGCTCATTTTGTCTTTTTCAATATACAAATTTTAAAAATACTACAA
2561 TATTTAACTAAGGCCCAACCGATTTCCATAATGTAGCAGTTACCGTGTTCACCTCACACTAAGGCCTAGAGTTTGCTCTG
2641 ATATGCATTTGGATGATTAATGTTATGCTGTTCTTTCATGTGAATGTCAAGACATGGAGGGTGTTTGTAATTTTATGGTA
2721 AAATTAATCCTTCTTACACATAATGGTGTCTTAAAATTGACAAAAAATGAGCACTTACAATTGTATGTCTCCTCAAATGA
2801 AAATTCTTTATCTGAAATTTTAAAAGACATTGATTCCACATGTAAGGATTTTTCATCTGAAGTACAATAATGCACAATCA
2881 GTGTTGCTCAAACTGCTTTATACTTATAAACAGCCATCTTAAATAAGCAACGTATTGTGAGTACTGATATGTATATAATA
2961 AAAATTATCAAAGAAAATTAACTGCCAGTCATTTGTAAATGCTGTCTACTCCTGAAAGCCTTCCTTCATCTCTATTTAGT
3041 TAATAATGTGCTCTCTCCTCCTGTTTTGAAACCCCATAGCTCTCTACACCTCTTATTGTACATCACTCTACTTTGCATTG
3121 GAGTTCTGTTTCTATATGTACTTATTCACCTGTTGCCTAAACATGCACTGTTCCTAAAAGGTACAGTTTTTGCTCAAAAT
3201 ATATGAAAGGAAAGATAATCAGTTCTTAAAGTTTGGTATGCTAAATAAGCACCCAGGGAACTTACCTGCTCCACCTCACC
3281 CCAGAAATTGATTATTCAGGTCTGGAATATGGCTCAGGATTCTTAATTTTCAACCAACACAATATAGAATCCTGTCAGTT
3361 ATCCTTGGATCATTTGCTAAGTGATCTTGCAAAATCAAAACTCCTTTGAGACTATTTCATTTTCAGAAATATTTTAAAAC
3441 TTGTTCAGAAACATCTTAAAACTTGTTAGCATATAGGAAAAGTACAATGCTTGGTGTAGGTAGGTTATTATTTGGTCATT
3521 TCCCTCAAACCATCCAGACAAGCCACTCTTCTACCACAAGCTGGTAGAAATCCTTAGGCACCTTTCTGCTTCTGCACTGC
3601 TATCACTTTCAGGTGTCTAAGGCTTCTGGAAGGCTGTTGTCATAACCTGGAGCCATACACCTAATGTACGTCTGGGGAAA
3681 GGACACCAATTAAAGAATCTAGAGCTAGGATGATGTTACATAAGACAGGGCACAATGGAGATGGACTCTGGATCCCTGCA
3761 TCTGAAAGAAAAAGGCAAGAAAATGCAGGGCAGGGAAAATCCTGAAGGTCTTCACTGACCATGAATTAAAATCCTAATTG
3841 ACAGTTTTACAAACAAAAACCCTCGTTTTAGTACTTGTGTTGTTTTTGTTTCTGTTTTAACAAGCTTAGATTTATTATTG
3921 TGCCTTTTATGGAAGATGAGGAAGAAATAGGAAAGCAGTAAAATGAACAATGAGAATCTGTTACCCAAACTGATATAAAC
4001 TCCCTCAGAAAGAAAGATACTACTCCCTAATCCTGGAAGTGTTAAGTGGCAATAATGATCAAATGTTGTAAAGGGGATTG
4081 TTACTACAGCTAATATGAAATGGGAGGCTGGACTAAATCTAACCTTTCTACCCTTGATTTCAATTCTAAAAGGACACGTA
4161 ATACCATTGCAGAAAGAAAAGACAGTTCCAAATGATAAATTTTAGAGTTGTTTTGCTAGGATGCAAGAGAAATTGGATAA
4241 GTGGACCACTCATACGTTGCTGGTGAGATATGAAATAGTAGAGCCACTGTGGAAAATATTCTTGGCAGTTTCTTATAAAA
4321 CTAAACATACATTTAACATATAACTGGCATTTGTACTACTTGACAGTTATCCCTGAGAAGTTAAAACTTAACATTCACAA
4401 ATGTTACATAGCACCTTCATTTATAATAGCCAAAACCCGGAAACAACCTGGATGTCCTTCAAAAAGAGTGAATGGTTTAG
4481 TATGTCCACACCATGGAATACTAAATAGTAATATGAAGGAACAAACTACTGATACATGTAACAAATTGCATGGACCTCAA
4561 GGGAATTATGCTTGGGTGGTTTGGGGGGACAATCCTAAAGTTTTACACACTGTATGATTCTGTTTTTGTAACATTCTTAA
4641 ATAATAAAGCTATAGAGATGGGAAACAAGATTCGTGGTTGCCAGGTCTTGGGACTGAAGGGAAGGAGAATGTGGCTATAA
4721 AGGGAGCCTTGTGGTGGAAAAGTTCTGTAGTTTGATTGTGGTGATTACATAAATATACATGTGAAATGTTAGAAGTATTT
4801 ATAGCTGAAACATATTAGTATGTTGGTATATACATATTTCTGACTAATTAATTTCGCCATGTTGCCCAGGCTGGTCTCGA
4881 ACTCCTAAGCTCAAGTGATGTGCCCGCCTCAACTTCCCAAGTGCTGAGATTACAGGCGTGAGCCACCATGTCCGGCCTGT
4961 TTTTTCCTATGCATGCATAATTACGATCAAGTTTAATTTGTAATTAGGCACATTAAGAGATTAACAATAGCTAACAAAAT
5041 GGAACAATTACAACAATATATTGTAATAAAAGTTATGCAAATGTGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acAUCCG--ACCCCUAUUUACUUAu 5'
            ||||:  |    ||||||||:| 
Target 5' ctTAGGTGATTTAAATAAATGAGTa 3'
 443 - 467 143.00 -12.10
2 
miRNA  3' acAUCCGACCCCU-AUUUACUUau 5'
            ||||:|    | |:||||||  
Target 5' taTAGGTT--TAACTGAATGAAgc 3'
 374 - 395 133.00 -9.10
3 
miRNA  3' acAUCCGACCCCUA-UUUACUUau 5'
            ||||   |  :| |||||||  
Target 5' aaTAGGAAAGCAGTAAAATGAAca 3'
 3946 - 3969 133.00 -6.13
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
787206 66 ClinVar
746730 76 ClinVar
COSM164962 3 COSMIC
COSM9791693 10 COSMIC
COSM198480 15 COSMIC
COSM2260312 20 COSMIC
COSM7136918 20 COSMIC
COSM9067336 21 COSMIC
COSM5633528 27 COSMIC
COSM4553778 67 COSMIC
COSM4851645 104 COSMIC
COSM8976381 108 COSMIC
COSM4187125 126 COSMIC
COSM8851218 145 COSMIC
COSN31606080 176 COSMIC
COSN6050614 223 COSMIC
COSN26330491 389 COSMIC
COSN30108193 413 COSMIC
COSN25461024 632 COSMIC
COSN31490441 647 COSMIC
COSN31519419 852 COSMIC
COSN8521725 1439 COSMIC
COSN24296917 1483 COSMIC
COSN31486802 1634 COSMIC
COSN31960273 1640 COSMIC
COSN31570390 1718 COSMIC
COSN31611187 1753 COSMIC
COSN31606220 1844 COSMIC
COSN31567719 1867 COSMIC
COSN10056379 1877 COSMIC
COSN31486355 2169 COSMIC
COSN31596753 2173 COSMIC
COSN31486357 2210 COSMIC
COSN6050613 2555 COSMIC
COSN31606769 2581 COSMIC
COSN26550685 2617 COSMIC
COSN26549072 2625 COSMIC
COSN19122556 2830 COSMIC
COSN1463787 2980 COSMIC
COSN28202031 3539 COSMIC
COSN25422145 3601 COSMIC
COSN32064915 3697 COSMIC
COSN1110186 3940 COSMIC
COSN17376852 4022 COSMIC
COSN15903529 4292 COSMIC
COSN10056378 4482 COSMIC
COSN32082233 4570 COSMIC
COSN6952861 4911 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs757203766 1 dbSNP
rs201567448 3 dbSNP
rs908110609 6 dbSNP
rs987686117 20 dbSNP
rs763914442 21 dbSNP
rs367637033 25 dbSNP
rs138776730 29 dbSNP
rs200096396 30 dbSNP
rs34517779 30 dbSNP
rs141023775 33 dbSNP
rs1253191973 36 dbSNP
rs1205422835 38 dbSNP
rs968815430 44 dbSNP
rs1432970494 47 dbSNP
rs1278553727 49 dbSNP
rs1236979367 51 dbSNP
rs542728308 56 dbSNP
rs1282390218 58 dbSNP
rs1306915319 60 dbSNP
rs531183657 65 dbSNP
rs116536133 66 dbSNP
rs773633377 68 dbSNP
rs772462043 72 dbSNP
rs147557786 76 dbSNP
rs1463319788 77 dbSNP
rs1175184263 79 dbSNP
rs7532639 82 dbSNP
rs755911006 86 dbSNP
rs755162990 90 dbSNP
rs200732467 91 dbSNP
rs780134369 95 dbSNP
rs1182997092 97 dbSNP
rs1412613806 105 dbSNP
rs1187406117 107 dbSNP
rs1485435315 113 dbSNP
rs1278442768 118 dbSNP
rs148407916 119 dbSNP
rs1181991518 120 dbSNP
rs1475907958 121 dbSNP
rs1260361781 124 dbSNP
rs1367277085 129 dbSNP
rs751473671 130 dbSNP
rs1473965497 132 dbSNP
rs763992993 138 dbSNP
rs1237458486 139 dbSNP
rs1319287429 142 dbSNP
rs1166171740 147 dbSNP
rs1307011278 148 dbSNP
rs1269004983 151 dbSNP
rs1413612956 154 dbSNP
rs1388171539 161 dbSNP
rs1455777050 167 dbSNP
rs758206957 168 dbSNP
rs752436555 169 dbSNP
rs1415071837 172 dbSNP
rs891128876 175 dbSNP
rs764885022 176 dbSNP
rs1215118584 178 dbSNP
rs375367558 179 dbSNP
rs776242162 182 dbSNP
rs1164198781 194 dbSNP
rs1002722321 195 dbSNP
rs1474919435 199 dbSNP
rs1047137141 203 dbSNP
rs1326834385 204 dbSNP
rs905802159 205 dbSNP
rs765955974 207 dbSNP
rs1229798822 213 dbSNP
rs995322494 214 dbSNP
rs1294146657 218 dbSNP
rs1482624785 219 dbSNP
rs867316009 221 dbSNP
rs898240637 235 dbSNP
rs745607655 237 dbSNP
rs1254668233 243 dbSNP
rs994701322 244 dbSNP
rs1189269315 253 dbSNP
rs778722621 261 dbSNP
rs1471826308 265 dbSNP
rs1364651167 277 dbSNP
rs1465599417 282 dbSNP
rs1338440962 284 dbSNP
rs939792083 290 dbSNP
rs1311769890 300 dbSNP
rs540103423 309 dbSNP
rs1404449337 316 dbSNP
rs890744542 317 dbSNP
rs1307366592 321 dbSNP
rs1348350424 332 dbSNP
rs1411470738 334 dbSNP
rs1375495953 340 dbSNP
rs770863397 343 dbSNP
rs769814003 348 dbSNP
rs1305636967 350 dbSNP
rs749349580 351 dbSNP
rs948234735 353 dbSNP
rs1345123752 371 dbSNP
rs1212158860 375 dbSNP
rs916805626 376 dbSNP
rs1482267247 384 dbSNP
rs1184865775 391 dbSNP
rs186464666 393 dbSNP
rs933529013 394 dbSNP
rs556758937 397 dbSNP
rs922204390 398 dbSNP
rs370086630 400 dbSNP
rs1174239420 411 dbSNP
rs1379396224 419 dbSNP
rs1165018671 421 dbSNP
rs1435451757 423 dbSNP
rs1167849249 424 dbSNP
rs947579411 438 dbSNP
rs1456095949 441 dbSNP
rs1298601444 446 dbSNP
rs1366646415 447 dbSNP
rs1368211887 463 dbSNP
rs914756286 465 dbSNP
rs1160335198 477 dbSNP
rs938993867 493 dbSNP
rs1227099698 505 dbSNP
rs1421389048 509 dbSNP
rs1340753934 533 dbSNP
rs1207930641 534 dbSNP
rs1252193824 534 dbSNP
rs545675853 535 dbSNP
rs1189655962 539 dbSNP
rs977864378 542 dbSNP
rs1182104268 555 dbSNP
rs1454746454 556 dbSNP
rs1188071229 558 dbSNP
rs1388245147 560 dbSNP
rs1431475089 570 dbSNP
rs1171072073 579 dbSNP
rs1349037799 589 dbSNP
rs956167619 605 dbSNP
rs575436381 607 dbSNP
rs1220473810 611 dbSNP
rs981437710 612 dbSNP
rs964543181 617 dbSNP
rs557159594 620 dbSNP
rs1294687453 624 dbSNP
rs1018840713 627 dbSNP
rs1009263744 628 dbSNP
rs1264606152 646 dbSNP
rs955401016 647 dbSNP
rs969928583 652 dbSNP
rs1026092147 655 dbSNP
rs1267440643 666 dbSNP
rs1469126038 670 dbSNP
rs1318645047 677 dbSNP
rs1246200806 687 dbSNP
rs1286320697 688 dbSNP
rs1022876125 701 dbSNP
rs1409141810 713 dbSNP
rs542334895 716 dbSNP
rs898554995 720 dbSNP
rs1038433064 735 dbSNP
rs898289012 737 dbSNP
rs1304458150 740 dbSNP
rs1015428337 750 dbSNP
rs1389646260 754 dbSNP
rs895324433 757 dbSNP
rs1159492023 763 dbSNP
rs1004344350 765 dbSNP
rs890890572 766 dbSNP
rs1430879703 771 dbSNP
rs1056710250 784 dbSNP
rs1379152606 795 dbSNP
rs1226959888 796 dbSNP
rs939636437 802 dbSNP
rs367611230 808 dbSNP
rs932347378 810 dbSNP
rs1266502991 813 dbSNP
rs1466283811 826 dbSNP
rs900749620 832 dbSNP
rs1216665954 834 dbSNP
rs181890200 836 dbSNP
rs553416236 842 dbSNP
rs1431514505 849 dbSNP
rs749625871 856 dbSNP
rs1196897208 860 dbSNP
rs1472160866 864 dbSNP
rs1156468490 869 dbSNP
rs1413785936 873 dbSNP
rs1400768825 876 dbSNP
rs866340718 877 dbSNP
rs947667527 898 dbSNP
rs914955140 904 dbSNP
rs1262765722 907 dbSNP
rs974499668 918 dbSNP
rs1207136615 919 dbSNP
rs943175918 921 dbSNP
rs747253298 930 dbSNP
rs1466036785 932 dbSNP
rs753034599 954 dbSNP
rs75625538 957 dbSNP
rs1227663154 964 dbSNP
rs1224549685 966 dbSNP
rs1324260325 971 dbSNP
rs1053305354 976 dbSNP
rs1230506106 986 dbSNP
rs1258187210 991 dbSNP
rs1482594043 999 dbSNP
rs1179817402 1002 dbSNP
rs1330014561 1009 dbSNP
rs1026245390 1010 dbSNP
rs973118383 1019 dbSNP
rs571160041 1026 dbSNP
rs1318489698 1029 dbSNP
rs934728749 1036 dbSNP
rs1190286494 1037 dbSNP
rs1422381363 1044 dbSNP
rs1415709771 1046 dbSNP
rs559245812 1049 dbSNP
rs1176040461 1059 dbSNP
rs1376644017 1076 dbSNP
rs1383591249 1078 dbSNP
rs1337918210 1081 dbSNP
rs1429510761 1081 dbSNP
rs1064797 1088 dbSNP
rs1016939123 1098 dbSNP
rs1365539773 1107 dbSNP
rs1236656629 1123 dbSNP
rs1280940956 1126 dbSNP
rs41286831 1133 dbSNP
rs1320362958 1134 dbSNP
rs570262488 1137 dbSNP
rs981404754 1143 dbSNP
rs145944952 1146 dbSNP
rs895314695 1147 dbSNP
rs1274783059 1150 dbSNP
rs1035620569 1157 dbSNP
rs1003784763 1163 dbSNP
rs74573613 1173 dbSNP
rs1455175011 1179 dbSNP
rs766823537 1182 dbSNP
rs974356782 1186 dbSNP
rs946331824 1202 dbSNP
rs1167293019 1205 dbSNP
rs1399039092 1207 dbSNP
rs1323117060 1211 dbSNP
rs1348417562 1219 dbSNP
rs1443193254 1221 dbSNP
rs1304165245 1225 dbSNP
rs751365833 1230 dbSNP
rs962674497 1231 dbSNP
rs1373723838 1237 dbSNP
rs1038800075 1240 dbSNP
rs1195547727 1243 dbSNP
rs943124970 1249 dbSNP
rs1213944857 1250 dbSNP
rs1015813197 1252 dbSNP
rs1447916938 1253 dbSNP
rs911716246 1254 dbSNP
rs1207927069 1256 dbSNP
rs1191632014 1257 dbSNP
rs1375340725 1258 dbSNP
rs1475940383 1263 dbSNP
rs1163111191 1266 dbSNP
rs1412079495 1267 dbSNP
rs1461700047 1269 dbSNP
rs987683686 1272 dbSNP
rs929171293 1275 dbSNP
rs1433039639 1283 dbSNP
rs1280571744 1284 dbSNP
rs1327011543 1289 dbSNP
rs190251164 1290 dbSNP
rs1282156191 1291 dbSNP
rs1343616459 1292 dbSNP
rs1233483249 1296 dbSNP
rs1004077347 1300 dbSNP
rs955107454 1306 dbSNP
rs1229127262 1309 dbSNP
rs973351588 1318 dbSNP
rs1264477154 1332 dbSNP
rs1029453612 1334 dbSNP
rs1199555157 1336 dbSNP
rs1187474061 1339 dbSNP
rs1453911538 1344 dbSNP
rs1408776560 1349 dbSNP
rs1332697241 1358 dbSNP
rs996609040 1362 dbSNP
rs750869000 1367 dbSNP
rs1165886610 1386 dbSNP
rs551423565 1401 dbSNP
rs1043430937 1403 dbSNP
rs1169779384 1404 dbSNP
rs1160435660 1407 dbSNP
rs1385784540 1435 dbSNP
rs1428035633 1436 dbSNP
rs1332151812 1443 dbSNP
rs1389858415 1448 dbSNP
rs990844661 1454 dbSNP
rs1287314148 1456 dbSNP
rs1184450388 1458 dbSNP
rs959477560 1461 dbSNP
rs1260740106 1462 dbSNP
rs1239017504 1474 dbSNP
rs1012214415 1484 dbSNP
rs1035124087 1489 dbSNP
rs144474757 1491 dbSNP
rs1200342473 1493 dbSNP
rs1278858373 1493 dbSNP
rs200442858 1495 dbSNP
rs902687704 1502 dbSNP
rs1273059469 1504 dbSNP
rs1417484759 1506 dbSNP
rs185703390 1508 dbSNP
rs1364417982 1518 dbSNP
rs1339618633 1520 dbSNP
rs1273393307 1525 dbSNP
rs1053680087 1534 dbSNP
rs1381749380 1545 dbSNP
rs528120636 1548 dbSNP
rs1435104103 1560 dbSNP
rs1038750253 1580 dbSNP
rs1336915154 1584 dbSNP
rs763664438 1593 dbSNP
rs928714069 1604 dbSNP
rs1045758587 1605 dbSNP
rs1408009628 1606 dbSNP
rs760169221 1609 dbSNP
rs564214173 1622 dbSNP
rs1370028165 1629 dbSNP
rs915886508 1634 dbSNP
rs1230500964 1635 dbSNP
rs1051523744 1636 dbSNP
rs1350766339 1638 dbSNP
rs1212229683 1644 dbSNP
rs1274308651 1658 dbSNP
rs974112428 1658 dbSNP
rs775139916 1673 dbSNP
rs1197745204 1677 dbSNP
rs115300137 1678 dbSNP
rs983015887 1682 dbSNP
rs1415664398 1684 dbSNP
rs1396976126 1685 dbSNP
rs941975373 1694 dbSNP
rs1352501399 1705 dbSNP
rs1463365814 1707 dbSNP
rs909872739 1708 dbSNP
rs1389639903 1722 dbSNP
rs376182180 1725 dbSNP
rs371216362 1726 dbSNP
rs181915341 1728 dbSNP
rs1472423188 1730 dbSNP
rs767093611 1742 dbSNP
rs528702331 1748 dbSNP
rs1235615960 1754 dbSNP
rs1297566583 1764 dbSNP
rs1184277569 1766 dbSNP
rs1481748539 1768 dbSNP
rs1230155116 1770 dbSNP
rs1252111086 1771 dbSNP
rs1488243392 1778 dbSNP
rs1212071573 1785 dbSNP
rs928004851 1788 dbSNP
rs1468987118 1790 dbSNP
rs1187812969 1807 dbSNP
rs563093697 1809 dbSNP
rs963801602 1811 dbSNP
rs1288134445 1814 dbSNP
rs967278656 1815 dbSNP
rs1228180881 1817 dbSNP
rs1022365916 1828 dbSNP
rs1352018616 1835 dbSNP
rs72715377 1843 dbSNP
rs139758702 1845 dbSNP
rs1011151613 1846 dbSNP
rs893377491 1847 dbSNP
rs1433776930 1853 dbSNP
rs1288784254 1855 dbSNP
rs1408566177 1856 dbSNP
rs1349892299 1868 dbSNP
rs549154840 1883 dbSNP
rs1296670435 1884 dbSNP
rs189213374 1890 dbSNP
rs999069444 1899 dbSNP
rs1275323307 1906 dbSNP
rs574993636 1908 dbSNP
rs553552965 1919 dbSNP
rs1208248772 1922 dbSNP
rs1045893308 1923 dbSNP
rs150866392 1929 dbSNP
rs141514999 1930 dbSNP
rs1187050240 1931 dbSNP
rs894591660 1932 dbSNP
rs1255156752 1934 dbSNP
rs1321323845 1954 dbSNP
rs1017891006 1962 dbSNP
rs1166620170 1965 dbSNP
rs148782877 1974 dbSNP
rs1456244893 1978 dbSNP
rs749452056 1979 dbSNP
rs941405662 1981 dbSNP
rs1346474068 1982 dbSNP
rs908547595 1988 dbSNP
rs537770412 1993 dbSNP
rs1433446107 2002 dbSNP
rs1471583365 2003 dbSNP
rs982683429 2008 dbSNP
rs933917395 2012 dbSNP
rs770609662 2015 dbSNP
rs1489257515 2016 dbSNP
rs1051942564 2018 dbSNP
rs1223433828 2026 dbSNP
rs1282168446 2028 dbSNP
rs183748604 2029 dbSNP
rs531965787 2030 dbSNP
rs963771880 2041 dbSNP
rs555154681 2044 dbSNP
rs1484560148 2045 dbSNP
rs1189888313 2049 dbSNP
rs1257975446 2051 dbSNP
rs1022085594 2065 dbSNP
rs867780150 2067 dbSNP
rs993298942 2072 dbSNP
rs897634021 2073 dbSNP
rs1160436382 2075 dbSNP
rs113813832 2076 dbSNP
rs956364793 2089 dbSNP
rs1433239264 2093 dbSNP
rs1227068203 2095 dbSNP
rs1315096880 2097 dbSNP
rs1376458434 2114 dbSNP
rs1329120880 2116 dbSNP
rs1283994996 2134 dbSNP
rs1221071185 2136 dbSNP
rs1441683866 2137 dbSNP
rs1278033885 2140 dbSNP
rs1375596964 2149 dbSNP
rs1037524680 2159 dbSNP
rs1031086551 2169 dbSNP
rs1302582139 2169 dbSNP
rs1280724473 2173 dbSNP
rs1365598981 2173 dbSNP
rs1437051042 2175 dbSNP
rs1201971612 2187 dbSNP
rs1274418124 2188 dbSNP
rs1431791033 2195 dbSNP
rs1234300393 2198 dbSNP
rs915804660 2200 dbSNP
rs1190193237 2203 dbSNP
rs1392725269 2212 dbSNP
rs1453054706 2215 dbSNP
rs1176101795 2217 dbSNP
rs1376401951 2218 dbSNP
rs1409802978 2219 dbSNP
rs1483514852 2230 dbSNP
rs1055647331 2242 dbSNP
rs74101447 2246 dbSNP
rs1443212397 2249 dbSNP
rs1322357309 2251 dbSNP
rs928027882 2258 dbSNP
rs1274311268 2259 dbSNP
rs1236359007 2263 dbSNP
rs907476033 2266 dbSNP
rs764690437 2274 dbSNP
rs749288544 2275 dbSNP
rs982587658 2275 dbSNP
rs41286829 2276 dbSNP
rs1176509556 2281 dbSNP
rs1274666008 2283 dbSNP
rs1437978408 2295 dbSNP
rs546328950 2298 dbSNP
rs894547036 2304 dbSNP
rs1469442341 2312 dbSNP
rs1038423317 2317 dbSNP
rs1196014856 2319 dbSNP
rs941446156 2323 dbSNP
rs1378778500 2325 dbSNP
rs1475290429 2328 dbSNP
rs1166449854 2333 dbSNP
rs1422113083 2342 dbSNP
rs1410700589 2344 dbSNP
rs1434343881 2345 dbSNP
rs958197770 2347 dbSNP
rs1392343319 2351 dbSNP
rs1422479187 2356 dbSNP
rs1326478264 2358 dbSNP
rs1325848656 2360 dbSNP
rs887093805 2367 dbSNP
rs1047522505 2374 dbSNP
rs1271653767 2375 dbSNP
rs1339854214 2381 dbSNP
rs933883609 2385 dbSNP
rs954522539 2386 dbSNP
rs1336286402 2391 dbSNP
rs1030021471 2393 dbSNP
rs922537866 2403 dbSNP
rs1446872443 2405 dbSNP
rs1191697337 2410 dbSNP
rs775807698 2414 dbSNP
rs1478378632 2420 dbSNP
rs1164455800 2423 dbSNP
rs1416029308 2426 dbSNP
rs534301810 2429 dbSNP
rs1207299653 2433 dbSNP
rs975242791 2438 dbSNP
rs942545211 2439 dbSNP
rs1264237541 2441 dbSNP
rs1398829428 2450 dbSNP
rs1005970342 2451 dbSNP
rs1015984759 2451 dbSNP
rs1326774445 2451 dbSNP
rs570456113 2464 dbSNP
rs915066032 2481 dbSNP
rs1356899957 2482 dbSNP
rs6675991 2483 dbSNP
rs748179577 2496 dbSNP
rs1055636065 2499 dbSNP
rs938636429 2505 dbSNP
rs1203870489 2509 dbSNP
rs1287020220 2511 dbSNP
rs1300707419 2515 dbSNP
rs1187756496 2522 dbSNP
rs1255848608 2523 dbSNP
rs1476275348 2540 dbSNP
rs1188530678 2547 dbSNP
rs1363258362 2548 dbSNP
rs1468702726 2552 dbSNP
rs1160202723 2572 dbSNP
rs1030637871 2581 dbSNP
rs981768685 2584 dbSNP
rs971601231 2593 dbSNP
rs1310790022 2595 dbSNP
rs1377070504 2605 dbSNP
rs1367673161 2611 dbSNP
rs1024550659 2613 dbSNP
rs1013130780 2615 dbSNP
rs117599057 2616 dbSNP
rs56675391 2628 dbSNP
rs1240639907 2629 dbSNP
rs1281774330 2636 dbSNP
rs1364214047 2640 dbSNP
rs548405843 2641 dbSNP
rs887219361 2644 dbSNP
rs1304786744 2648 dbSNP
rs529958328 2652 dbSNP
rs1201216865 2661 dbSNP
rs989574981 2673 dbSNP
rs1417385598 2677 dbSNP
rs1183999163 2679 dbSNP
rs1381017817 2682 dbSNP
rs998227407 2687 dbSNP
rs1171721685 2691 dbSNP
rs747353159 2694 dbSNP
rs559870613 2695 dbSNP
rs1039606725 2701 dbSNP
rs1466405297 2716 dbSNP
rs541567292 2735 dbSNP
rs1297243042 2736 dbSNP
rs189783057 2740 dbSNP
rs1392774330 2745 dbSNP
rs1233239788 2758 dbSNP
rs1301933484 2768 dbSNP
rs1328874756 2768 dbSNP
rs769970443 2768 dbSNP
rs1350472650 2771 dbSNP
rs1054041004 2778 dbSNP
rs955011074 2778 dbSNP
rs1197801375 2779 dbSNP
rs1238827355 2783 dbSNP
rs1186294957 2784 dbSNP
rs1191649438 2785 dbSNP
rs1254881624 2787 dbSNP
rs1433555794 2796 dbSNP
rs1449173224 2810 dbSNP
rs543419618 2814 dbSNP
rs1184060503 2826 dbSNP
rs923707393 2830 dbSNP
rs1255460470 2831 dbSNP
rs981738903 2836 dbSNP
rs970399893 2837 dbSNP
rs546 2838 dbSNP
rs1324455478 2847 dbSNP
rs1370443996 2855 dbSNP
rs1015959613 2871 dbSNP
rs540600884 2874 dbSNP
rs184897927 2875 dbSNP
rs374675763 2877 dbSNP
rs1005965533 2881 dbSNP
rs765290599 2881 dbSNP
rs192570147 2882 dbSNP
rs1272687871 2896 dbSNP
rs187580984 2906 dbSNP
rs3171 2907 dbSNP
rs1006159661 2908 dbSNP
rs558215484 2909 dbSNP
rs552626348 2931 dbSNP
rs546452165 2932 dbSNP
rs1193904224 2935 dbSNP
rs1416790415 2939 dbSNP
rs1042031298 2940 dbSNP
rs544668878 2943 dbSNP
rs1349983899 2950 dbSNP
rs892501574 2953 dbSNP
rs901133625 2977 dbSNP
rs377399571 2978 dbSNP
rs7532195 2981 dbSNP
rs1166275213 2982 dbSNP
rs752163641 2987 dbSNP
rs1428739162 2990 dbSNP
rs368856470 2993 dbSNP
rs1354990160 2996 dbSNP
rs1369379321 3008 dbSNP
rs1231696513 3024 dbSNP
rs114108782 3033 dbSNP
rs201890911 3036 dbSNP
rs1214943515 3042 dbSNP
rs1258941778 3043 dbSNP
rs1053607140 3063 dbSNP
rs1486716705 3073 dbSNP
rs1256146649 3083 dbSNP
rs933501821 3086 dbSNP
rs1473993643 3089 dbSNP
rs556316808 3096 dbSNP
rs1484041621 3097 dbSNP
rs1249759935 3098 dbSNP
rs1204667942 3099 dbSNP
rs767181594 3103 dbSNP
rs972733373 3106 dbSNP
rs1344019130 3108 dbSNP
rs1422069783 3110 dbSNP
rs961685200 3110 dbSNP
rs1265799636 3116 dbSNP
rs1015906740 3118 dbSNP
rs984493003 3119 dbSNP
rs536069733 3128 dbSNP
rs149597334 3134 dbSNP
rs1228952519 3144 dbSNP
rs949157687 3145 dbSNP
rs1351755925 3159 dbSNP
rs916220047 3163 dbSNP
rs990921135 3165 dbSNP
rs1408812842 3168 dbSNP
rs1240804867 3181 dbSNP
rs1279292477 3185 dbSNP
rs1391071521 3186 dbSNP
rs79415343 3202 dbSNP
rs542843485 3210 dbSNP
rs910168067 3212 dbSNP
rs1237755066 3214 dbSNP
rs1480024856 3217 dbSNP
rs1174908626 3218 dbSNP
rs1409549329 3222 dbSNP
rs1456649286 3230 dbSNP
rs984299160 3233 dbSNP
rs769928627 3247 dbSNP
rs1368263412 3265 dbSNP
rs1394821941 3266 dbSNP
rs1002672803 3271 dbSNP
rs1336384045 3278 dbSNP
rs971647707 3289 dbSNP
rs951597977 3295 dbSNP
rs1160487828 3301 dbSNP
rs1020194711 3307 dbSNP
rs1473883210 3309 dbSNP
rs1379250944 3318 dbSNP
rs1240747383 3327 dbSNP
rs1302643398 3329 dbSNP
rs1025818458 3333 dbSNP
rs1010606072 3335 dbSNP
rs976808426 3342 dbSNP
rs965464869 3345 dbSNP
rs1279077394 3352 dbSNP
rs1306505266 3354 dbSNP
rs1202038494 3358 dbSNP
rs1239423114 3362 dbSNP
rs773845977 3369 dbSNP
rs1181627927 3374 dbSNP
rs1457851983 3382 dbSNP
rs1179785385 3402 dbSNP
rs1018272716 3412 dbSNP
rs1007326832 3422 dbSNP
rs1452955986 3433 dbSNP
rs893720043 3440 dbSNP
rs1174609044 3446 dbSNP
rs1452403427 3452 dbSNP
rs766262978 3454 dbSNP
rs1409556036 3460 dbSNP
rs1168653958 3465 dbSNP
rs1269655641 3466 dbSNP
rs1402523808 3468 dbSNP
rs182941468 3473 dbSNP
rs567508344 3474 dbSNP
rs138258088 3478 dbSNP
rs1438543830 3482 dbSNP
rs1275174136 3487 dbSNP
rs999456792 3494 dbSNP
rs775919457 3495 dbSNP
rs147037394 3497 dbSNP
rs1000880653 3501 dbSNP
rs902332972 3502 dbSNP
rs1317981349 3504 dbSNP
rs1212594246 3507 dbSNP
rs1046228752 3509 dbSNP
rs1050942467 3513 dbSNP
rs1042043495 3521 dbSNP
rs945656269 3529 dbSNP
rs1487354920 3537 dbSNP
rs915486006 3539 dbSNP
rs192611254 3550 dbSNP
rs1184983497 3553 dbSNP
rs933469509 3553 dbSNP
rs1209242736 3556 dbSNP
rs1466339546 3579 dbSNP
rs553673444 3581 dbSNP
rs1285892757 3602 dbSNP
rs1406973422 3611 dbSNP
rs1324175950 3619 dbSNP
rs1325620073 3633 dbSNP
rs547880823 3636 dbSNP
rs1331180891 3637 dbSNP
rs940976198 3643 dbSNP
rs949127363 3648 dbSNP
rs187826094 3654 dbSNP
rs1290851115 3656 dbSNP
rs182722220 3658 dbSNP
rs191006585 3665 dbSNP
rs1390431449 3670 dbSNP
rs1054798776 3680 dbSNP
rs1214817677 3681 dbSNP
rs958369572 3701 dbSNP
rs1459275253 3704 dbSNP
rs1478241099 3705 dbSNP
rs927030435 3719 dbSNP
rs1187534813 3720 dbSNP
rs1387182324 3721 dbSNP
rs1366767806 3722 dbSNP
rs1473847486 3724 dbSNP
rs1163762564 3726 dbSNP
rs1384251998 3727 dbSNP
rs1398887919 3729 dbSNP
rs981634544 3736 dbSNP
rs941727118 3741 dbSNP
rs1413744910 3757 dbSNP
rs1341727497 3759 dbSNP
rs1478364889 3767 dbSNP
rs1244967248 3770 dbSNP
rs1020558802 3771 dbSNP
rs1379469471 3774 dbSNP
rs908888233 3774 dbSNP
rs984742208 3819 dbSNP
rs930228735 3820 dbSNP
rs1238634114 3822 dbSNP
rs918727823 3829 dbSNP
rs1196975965 3832 dbSNP
rs1288546290 3844 dbSNP
rs1488842310 3849 dbSNP
rs976945231 3850 dbSNP
rs1173087275 3855 dbSNP
rs1432861672 3860 dbSNP
rs576398557 3864 dbSNP
rs1018409420 3865 dbSNP
rs776800791 3870 dbSNP
rs1189040128 3871 dbSNP
rs561229498 3874 dbSNP
rs375968105 3875 dbSNP
rs1466194686 3877 dbSNP
rs1160416308 3878 dbSNP
rs1032345233 3880 dbSNP
rs1266093458 3881 dbSNP
rs1380648534 3882 dbSNP
rs1208041633 3884 dbSNP
rs1433931728 3885 dbSNP
rs1300709859 3886 dbSNP
rs957245122 3891 dbSNP
rs1032946223 3894 dbSNP
rs185755669 3905 dbSNP
rs1257272284 3917 dbSNP
rs1333506063 3923 dbSNP
rs572274141 3936 dbSNP
rs1445167485 3938 dbSNP
rs1312165480 3944 dbSNP
rs1354853181 3948 dbSNP
rs1234107894 3961 dbSNP
rs781196094 3965 dbSNP
rs1330215072 3970 dbSNP
rs1201270158 3979 dbSNP
rs553961615 3980 dbSNP
rs1437643126 3986 dbSNP
rs1050526201 3988 dbSNP
rs1238789141 3997 dbSNP
rs1453728558 3999 dbSNP
rs375153657 3999 dbSNP
rs1173620627 4001 dbSNP
rs998033162 4002 dbSNP
rs901997892 4007 dbSNP
rs747291638 4016 dbSNP
rs1036909604 4018 dbSNP
rs1363485544 4023 dbSNP
rs540727546 4027 dbSNP
rs772245991 4034 dbSNP
rs41286827 4036 dbSNP
rs558413725 4040 dbSNP
rs1378215945 4065 dbSNP
rs1440841907 4068 dbSNP
rs1299584152 4078 dbSNP
rs1333224540 4083 dbSNP
rs1234199172 4085 dbSNP
rs758807176 4087 dbSNP
rs1055250411 4091 dbSNP
rs1049311192 4093 dbSNP
rs937002991 4096 dbSNP
rs1465718435 4104 dbSNP
rs1391087456 4106 dbSNP
rs1258809652 4112 dbSNP
rs1190755305 4113 dbSNP
rs1451032147 4115 dbSNP
rs941793475 4123 dbSNP
rs887415210 4141 dbSNP
rs1269161674 4146 dbSNP
rs1433604395 4149 dbSNP
rs1192014017 4157 dbSNP
rs1245982863 4158 dbSNP
rs1047403149 4159 dbSNP
rs1466869152 4160 dbSNP
rs930196174 4167 dbSNP
rs1393129102 4170 dbSNP
rs949866437 4174 dbSNP
rs1192326167 4176 dbSNP
rs537035576 4179 dbSNP
rs1572343 4182 dbSNP
rs1387775577 4192 dbSNP
rs550992114 4197 dbSNP
rs1277970548 4199 dbSNP
rs988618127 4209 dbSNP
rs1257649529 4213 dbSNP
rs1278876058 4213 dbSNP
rs1334309171 4217 dbSNP
rs957193809 4218 dbSNP
rs1267205376 4221 dbSNP
rs976915794 4222 dbSNP
rs1488684727 4232 dbSNP
rs1204263572 4233 dbSNP
rs944221089 4237 dbSNP
rs911401355 4242 dbSNP
rs1198300570 4243 dbSNP
rs1193976297 4250 dbSNP
rs985908060 4262 dbSNP
rs1346530138 4269 dbSNP
rs1416486756 4272 dbSNP
rs958162782 4273 dbSNP
rs1163278400 4280 dbSNP
rs79314847 4281 dbSNP
rs1458877749 4312 dbSNP
rs1297918270 4314 dbSNP
rs1359060153 4315 dbSNP
rs1029437762 4316 dbSNP
rs978088239 4320 dbSNP
rs997540443 4326 dbSNP
rs1230190047 4327 dbSNP
rs1314953112 4330 dbSNP
rs1322197067 4345 dbSNP
rs1239369476 4349 dbSNP
rs1283572223 4356 dbSNP
rs1340431950 4358 dbSNP
rs201499742 4364 dbSNP
rs1216858042 4370 dbSNP
rs901901927 4399 dbSNP
rs1482073650 4403 dbSNP
rs183306008 4404 dbSNP
rs1449369970 4407 dbSNP
rs1024884657 4408 dbSNP
rs1013466450 4409 dbSNP
rs959161597 4410 dbSNP
rs1342842651 4420 dbSNP
rs1158612667 4426 dbSNP
rs757714694 4430 dbSNP
rs887983061 4438 dbSNP
rs1049301291 4439 dbSNP
rs1371256838 4443 dbSNP
rs1159466004 4447 dbSNP
rs1006354277 4448 dbSNP
rs937615130 4452 dbSNP
rs1304613230 4470 dbSNP
rs1445916363 4472 dbSNP
rs887562712 4474 dbSNP
rs1355567573 4488 dbSNP
rs1240690232 4491 dbSNP
rs754322973 4491 dbSNP
rs1277672359 4492 dbSNP
rs993199978 4508 dbSNP
rs780720354 4523 dbSNP
rs1170662546 4535 dbSNP
rs565842405 4535 dbSNP
rs191040791 4546 dbSNP
rs1428094495 4552 dbSNP
rs527908662 4564 dbSNP
rs754442566 4581 dbSNP
rs1388052218 4582 dbSNP
rs1480051867 4588 dbSNP
rs1045783898 4596 dbSNP
rs897403054 4597 dbSNP
rs1184110356 4618 dbSNP
rs1236949311 4622 dbSNP
rs1041284456 4628 dbSNP
rs532255129 4636 dbSNP
rs1370054416 4649 dbSNP
rs878873497 4651 dbSNP
rs1185351336 4655 dbSNP
rs1485031464 4658 dbSNP
rs1424935543 4659 dbSNP
rs571707547 4663 dbSNP
rs751282146 4674 dbSNP
rs912935062 4677 dbSNP
rs1049955708 4682 dbSNP
rs936733245 4687 dbSNP
rs1465220269 4700 dbSNP
rs765889793 4718 dbSNP
rs978057428 4732 dbSNP
rs966650938 4737 dbSNP
rs762808831 4743 dbSNP
rs1229315618 4747 dbSNP
rs1447450612 4752 dbSNP
rs143690447 4756 dbSNP
rs1282878754 4759 dbSNP
rs1233232171 4760 dbSNP
rs985360993 4761 dbSNP
rs1309976504 4764 dbSNP
rs1408221350 4773 dbSNP
rs1370264194 4774 dbSNP
rs750201381 4776 dbSNP
rs1316740908 4778 dbSNP
rs1196133844 4788 dbSNP
rs1324463279 4790 dbSNP
rs1459447821 4792 dbSNP
rs1405682698 4794 dbSNP
rs959330065 4809 dbSNP
rs1415724158 4812 dbSNP
rs770969202 4816 dbSNP
rs1474863174 4818 dbSNP
rs1033915003 4820 dbSNP
rs1006075645 4827 dbSNP
rs531425552 4828 dbSNP
rs531707475 4831 dbSNP
rs138197060 4837 dbSNP
rs1477621186 4846 dbSNP
rs976448654 4851 dbSNP
rs1471403190 4854 dbSNP
rs993254020 4855 dbSNP
rs765286216 4856 dbSNP
rs1221865044 4859 dbSNP
rs1347885329 4860 dbSNP
rs1453631018 4868 dbSNP
rs1004960411 4870 dbSNP
rs1275220057 4874 dbSNP
rs1216440689 4879 dbSNP
rs1288203766 4884 dbSNP
rs901469101 4890 dbSNP
rs371598830 4895 dbSNP
rs185947087 4905 dbSNP
rs1027810107 4912 dbSNP
rs1450235322 4913 dbSNP
rs1330480343 4917 dbSNP
rs1040080752 4921 dbSNP
rs1270077867 4935 dbSNP
rs1008472289 4937 dbSNP
rs560266294 4938 dbSNP
rs1425841463 4940 dbSNP
rs1050346520 4949 dbSNP
rs1045986262 4950 dbSNP
rs949718700 4953 dbSNP
rs1407026096 4954 dbSNP
rs1372719156 4956 dbSNP
rs1323918006 4958 dbSNP
rs369543702 4963 dbSNP
rs1359702510 4966 dbSNP
rs568867655 4966 dbSNP
rs1397718469 4970 dbSNP
rs936889242 4984 dbSNP
rs1340582808 4988 dbSNP
rs1243516532 4991 dbSNP
rs891502197 5006 dbSNP
rs1354793446 5011 dbSNP
rs925452676 5024 dbSNP
rs1292919260 5025 dbSNP
rs1353500277 5028 dbSNP
rs1438917754 5030 dbSNP
rs1265694660 5046 dbSNP
rs1447799045 5049 dbSNP
rs925705667 5057 dbSNP
rs935764812 5057 dbSNP
rs1473715758 5063 dbSNP
rs1049565918 5072 dbSNP
rs1042416575 5076 dbSNP
rs1417695547 5080 dbSNP
rs945483988 5085 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000479918.1 | 3UTR | UACAGAUAUAAACUACUGCAUCUUUUCUAUAAAACUGUGAUUAAGAAUUCUACCUCUCCUGUAUGGCUGUUACUGUACUGUACUCUCUGACUCCUUACCUAACAAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE42095 Differentiated embryonic stem cells 0.575 2.1e-3 0.500 7.6e-3 23 Click to see details
GSE28260 Renal cortex and medulla 0.61 1.3e-2 0.681 5.2e-3 13 Click to see details
GSE26953 Aortic valvular endothelial cells 0.375 3.5e-2 0.422 2.0e-2 24 Click to see details
GSE38226 Liver fibrosis 0.228 1.6e-1 0.174 2.3e-1 21 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.202 1.7e-1 0.278 8.9e-2 25 Click to see details
GSE32688 Pancreatic cancer -0.039 4.2e-1 -0.032 4.3e-1 32 Click to see details
GSE28544 Breast cancer 0.045 4.2e-1 0.508 5.6e-3 24 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
PRAD -0.289 0.02 -0.276 0.03 50 Click to see details
COAD -0.709 0.02 -0.643 0.04 8 Click to see details
BLCA 0.465 0.03 0.666 0 18 Click to see details
LUSC 0.301 0.03 0.220 0.09 38 Click to see details
PAAD 0.919 0.04 0.600 0.2 4 Click to see details
BRCA -0.184 0.05 -0.071 0.26 84 Click to see details
PCPG 0.973 0.07 1.000 0.5 3 Click to see details
STAD 0.202 0.13 0.175 0.17 32 Click to see details
KIRC 0.124 0.16 0.134 0.14 68 Click to see details
KICH -0.197 0.17 -0.176 0.2 25 Click to see details
HNSC 0.109 0.25 0.108 0.25 42 Click to see details
UCEC 0.147 0.27 0.046 0.43 19 Click to see details
KIRP 0.095 0.3 -0.021 0.45 32 Click to see details
LIHC 0.074 0.31 0.070 0.32 49 Click to see details
ESCA -0.151 0.33 -0.255 0.22 11 Click to see details
LUAD -0.131 0.34 -0.252 0.21 12 Click to see details
CESC 0.424 0.36 0.500 0.33 3 Click to see details
THCA -0.028 0.42 -0.131 0.16 59 Click to see details
CHOL -0.052 0.45 0.000 0.5 9 Click to see details
CHOL -0.052 0.45 0.000 0.5 9 Click to see details
CHOL -0.052 0.45 0.000 0.5 9 Click to see details
88 hsa-miR-664a-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT035824 HIAT1 major facilitator superfamily domain containing 14A 1 1
MIRT035826 FUS FUS RNA binding protein 1 1
MIRT069432 SIVA1 SIVA1 apoptosis inducing factor 2 2
MIRT071494 CALM1 calmodulin 1 2 2
MIRT100410 HSPA1B heat shock protein family A (Hsp70) member 1B 2 2
MIRT143469 CHD9 chromodomain helicase DNA binding protein 9 2 2
MIRT191113 ARF6 ADP ribosylation factor 6 2 2
MIRT235584 SNRPB2 small nuclear ribonucleoprotein polypeptide B2 2 8
MIRT339131 ARID1A AT-rich interaction domain 1A 2 2
MIRT437450 MAT1A methionine adenosyltransferase 1A 1 1
MIRT442234 BTD biotinidase 2 2
MIRT443321 SLC35G1 solute carrier family 35 member G1 2 2
MIRT443769 HLF HLF, PAR bZIP transcription factor 2 2
MIRT444352 KIAA1211 KIAA1211 2 2
MIRT456348 OLIG3 oligodendrocyte transcription factor 3 2 8
MIRT458866 CD55 CD55 molecule (Cromer blood group) 2 2
MIRT466169 TMED5 transmembrane p24 trafficking protein 5 2 2
MIRT470445 PPP1R15B protein phosphatase 1 regulatory subunit 15B 2 6
MIRT471524 PCGF3 polycomb group ring finger 3 2 6
MIRT477744 EDN1 endothelin 1 2 2
MIRT482885 CACNA2D3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 2 2
MIRT496336 PTPRT protein tyrosine phosphatase, receptor type T 2 2
MIRT497703 ARL6IP6 ADP ribosylation factor like GTPase 6 interacting protein 6 2 2
MIRT499068 CTBP1 C-terminal binding protein 1 2 4
MIRT500296 ZNF667 zinc finger protein 667 2 8
MIRT500506 ZBTB34 zinc finger and BTB domain containing 34 2 8
MIRT501964 MAPK8 mitogen-activated protein kinase 8 2 2
MIRT505457 SUB1 SUB1 homolog, transcriptional regulator 2 4
MIRT505955 RAN RAN, member RAS oncogene family 2 6
MIRT507512 DYNLL2 dynein light chain LC8-type 2 2 4
MIRT512953 MKI67 marker of proliferation Ki-67 2 2
MIRT520450 TSPAN2 tetraspanin 2 2 6
MIRT525997 MAGEL2 MAGE family member L2 2 2
MIRT526424 ZNF695 zinc finger protein 695 2 2
MIRT527364 KRTAP13-2 keratin associated protein 13-2 2 2
MIRT529612 H1F0 H1 histone family member 0 2 2
MIRT529811 TMLHE trimethyllysine hydroxylase, epsilon 2 2
MIRT530971 EXO5 exonuclease 5 2 4
MIRT531294 WNT7A Wnt family member 7A 2 2
MIRT531870 POF1B premature ovarian failure, 1B 2 2
MIRT532116 G6PC glucose-6-phosphatase catalytic subunit 2 2
MIRT533534 TPR translocated promoter region, nuclear basket protein 2 2
MIRT545934 ZBTB44 zinc finger and BTB domain containing 44 2 4
MIRT546649 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT548063 GNS glucosamine (N-acetyl)-6-sulfatase 2 2
MIRT548288 FAM3C family with sequence similarity 3 member C 2 4
MIRT551018 SPPL3 signal peptide peptidase like 3 2 2
MIRT551139 ZNF678 zinc finger protein 678 2 2
MIRT552398 ZNF487P zinc finger protein 487 1 1
MIRT555640 PHIP pleckstrin homology domain interacting protein 2 4
MIRT556267 MAPK6 mitogen-activated protein kinase 6 2 2
MIRT558864 CD2AP CD2 associated protein 2 2
MIRT559239 BEND4 BEN domain containing 4 2 2
MIRT559438 ARSJ arylsulfatase family member J 2 2
MIRT559793 ZNF415 zinc finger protein 415 2 2
MIRT562572 CBX6 chromobox 6 2 2
MIRT562741 ZNF83 zinc finger protein 83 2 2
MIRT564737 ZNF23 zinc finger protein 23 2 2
MIRT565174 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT566301 PPM1A protein phosphatase, Mg2+/Mn2+ dependent 1A 2 2
MIRT571656 SERBP1 SERPINE1 mRNA binding protein 1 2 2
MIRT610720 NAV2 neuron navigator 2 2 2
MIRT611486 ADCYAP1R1 ADCYAP receptor type I 2 4
MIRT617118 KANK2 KN motif and ankyrin repeat domains 2 2 2
MIRT617836 SIGLEC10 sialic acid binding Ig like lectin 10 2 2
MIRT636145 VLDLR very low density lipoprotein receptor 2 2
MIRT638060 YAE1D1 Yae1 domain containing 1 2 4
MIRT640159 CDK13 cyclin dependent kinase 13 2 2
MIRT644257 WEE2 WEE1 homolog 2 2 2
MIRT646838 TLDC1 TBC/LysM-associated domain containing 1 2 2
MIRT653074 ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2 2
MIRT657671 GPR26 G protein-coupled receptor 26 2 2
MIRT660601 AP3M2 adaptor related protein complex 3 mu 2 subunit 2 2
MIRT668908 CREB1 cAMP responsive element binding protein 1 2 2
MIRT672685 GTF2H5 general transcription factor IIH subunit 5 2 2
MIRT680977 DCAF17 DDB1 and CUL4 associated factor 17 2 2
MIRT682271 RS1 retinoschisin 1 2 2
MIRT702058 RNMT RNA guanine-7 methyltransferase 2 2
MIRT707786 UNK unkempt family zinc finger 2 2
MIRT709238 RANGAP1 Ran GTPase activating protein 1 2 2
MIRT710119 MED23 mediator complex subunit 23 2 2
MIRT710675 ADAP2 ArfGAP with dual PH domains 2 2 2
MIRT712884 NIPBL NIPBL, cohesin loading factor 2 2
MIRT719015 HPGD 15-hydroxyprostaglandin dehydrogenase 2 2
MIRT723323 COLEC10 collectin subfamily member 10 2 2
MIRT724947 TXNL1 thioredoxin like 1 2 2
MIRT725535 EN2 engrailed homeobox 2 2 2
MIRT734156 FHL1 four and a half LIM domains 1 3 0
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-664a Plx-4720 24180719 NSC757438 resistant High Thyroid Cancer cell line (8505c, BCPAP)
hsa-mir-664a Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-664a Fluorouracil 3385 NSC19893 approved resistant cell line (OE19)
hsa-miR-664a-3p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HT-29)
hsa-miR-664a-3p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (RKO)
hsa-miR-664a-3p Sorafenib 216239 NSC747971 approved resistant High Hepatocellular Carcinoma cell line (Huh-7)
hsa-miR-664a-3p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (SGC7901)
hsa-miR-664a-3p Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-664a-3p Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-664a-3p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375)
hsa-miR-664a-3p Fluorouracil 3385 NSC19893 approved resistant High Colorectal Cancer cell line (HCT-116)
hsa-miR-664a-3p Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-664a-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-664a-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-664a-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-664a-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-664a-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM11)
hsa-miR-664a-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM36)
hsa-miR-664a-3p Tamoxifen 2733525 NSC180973 approved resistant cell line (LCC2)
hsa-miR-664a-3p Fluorouracil 3385 NSC19893 approved resistant cell line (HCT15)
hsa-miR-664a-3p 4-Hydroxytamoxifen+Tamoxifen sensitive cell line (LY2)
hsa-miR-664a-3p Ethanol+Tamoxifen sensitive cell line (LY2)
hsa-miR-664a-3p Gemcitabine 60750 NSC613327 approved resistant cell line (MDA-231)
hsa-miR-664a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-664a-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-664a-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-664a-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-664a-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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