miRTarBase - #MIRT466864


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pre-miRNA Information
pre-miRNA hsa-mir-548al   
Genomic Coordinates chr11: 74399237 - 74399333
Description Homo sapiens miR-548al stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-548al
Sequence 65| AACGGCAAUGACUUUUGUACCA |86
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 1 11 + 74399301 29233923 MiREDiBase
A-to-I 2 11 + 74399302 29233923 MiREDiBase
A-to-I 11 11 + 74399311 29233923 MiREDiBase
A-to-I 22 11 + 74399322 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1006612080 4 dbSNP
rs1228098884 7 dbSNP
rs515924 8 dbSNP
rs145394973 13 dbSNP
rs1339767076 14 dbSNP
rs1409875902 16 dbSNP
Putative Targets

Gene Information
Gene Symbol STX6   
Synonyms -
Description syntaxin 6
Transcript NM_005819   
Expression
Putative miRNA Targets on STX6
3'UTR of STX6
(miRNA target sites are highlighted)		 
>STX6|NM_005819|3'UTR
   1 CGGCGGGGCCTCTGGGTGCGAGTTCCTCCTGCATATGAACCGAGGGGAGGAGGAGAAGCTGAGCACGTGTGACATTGCCG
  81 TCTACTCACATTCCTATCCTGGAAACATACTGCTGCACTGACTTTTCTCCGTGTGACCCCACAATTGACATGGCTCCTCC
 161 ATCCCAGCGCTGGAAGGGCCAGTGGGAAGAGGAAATAGATGTCTGCACTCCTGGCTGCAGCTGGACAACAGAAGCCCCAT
 241 GCCGCCTGTCCAGTTCGGAGGAGAACTAGCTGCTGCCTTGCCTTCCGGGACCTCGTTTGCTGAGGAGGGACTTACAGACT
 321 CCACTGGTGTTTTGCTGTTGCTCATTCCATGCATCTTTGGCAGCTCTTTTCTTCTGCTCAGACCCTTCCCCGTGCTCAGA
 401 CAGTGCACCGCTGTCCCATCTAAAGAAACCTGTCAGGAATACGAGCTTCTGGGTATGTTTCGTTTCCCATTGCTGTAGCA
 481 TTTCTTATCCCCTGAGAGCTGATGATTATTGAGGACAGAAGGCTCAGAAACAGTTTGTGACAGAAAATGCAGTGTTTCAT
 561 TTTTCAGGGATAAATGCTAAGATAAAATTGCTTTTCCAGGTCATTTTTTTTTGTGGTAAGAATAACTAATGGAAAATAAT
 641 GAAACACCCTGGGGTTTGGGGGTGCTAACAACTTGTGGCTTTAACTGACAGGAGCAATTAAAAAGAGCAAGAGGGTTCTG
 721 CATTGGCATAGCTTAGGGAAGGGTTAATGATGTCGCCACAGGTCAGCTCCTGATCCTTGCCGACTTGATGTTGCTGTACC
 801 AGGGCTTCCTCCCCAGAGGTGCAGCTTGCGTTTTGAGGGTGATTGCTACATATGTTGTTGCTAAACAGCTCAGTAACACA
 881 CTTGAATGAATTTGGATACCAGATTGTCCTCATTACAGTTCTTTTACTCTTAGGGCACTCTACACTGGGGGTTGGGGTTG
 961 GGAGTGGTTAGTACATTTATTACATTTATTAAGAAACGTAATGACATAAAAGGTTAGCTCTGGGCCAGACTTCTCTTACT
1041 CTGTGGGTAATGGCAAGGATGTGTAGGTAAACTTGGTTCTTTTTTTTCCCTAAGATGACAGCTTGATTTTATCATCTGCA
1121 GTCAAATAACTGAGCCAATCCAAATTTAAATGATAGATGCTTTAATTGAGTTTAAGTAGCTGAAACTGCTGAGACACTAA
1201 ACTTTAACCTTCTGATGACTTTTTAAAATGCCTCAAATGTGCACATGTATATAGGATATTTTTATAACTTCCCTGATGAA
1281 TAATCTGATATTAAAGTAGTATTTGGACCCAGAGCCAGAACTCGGTGGTGGAGGCTGCTGGTCTCTCCTCACCACCTTCT
1361 TTTGCACTTGGAAAGAACAGCAACATCTGGATAGAGTTCTAGCTTTGACTTCTCATTTCCTTGTCTTTTTGGGTGCATTC
1441 CTCAGCACACTTTTTTTTTAAACCTTTTTGTTTTGTTTTGTTTGTATTTCATGTGGTTTTATTTGGGGGTTTTGGTTTTT
1521 TCACCCTTTTTTGTGATTTGCAATGATGTGCTTGCCCAGCTAACTTTTGAATTGCACTTTTTAATAAATATTCTTAACAA
1601 TTTTTGAAGAAGGATATTTTATCTCATTTGAGATCATGGTAGGTTAAGAAAATATGCCTGTTGATGAAAGCTAAAAGCAA
1681 ATTTATGAAACTAAAAGGGTGATTGACATCCATGTTTACACTCCGCTCTAATGTTTGATATATAAATAAGTTATTTTCAA
1761 ATTAGGAAAAAACAGTGAGTATTACAAAGGGCTTCAGATGTTTAGAGTACTAGGTTATTTATGTTTTACAAAGTTTGAAT
1841 CTTCTATAAACTAAGAAAGGGGATGATCCTTAGATTTGCATTAAAATATAGAAGTCTTTTAAAGTAAATGTGAACCTTGT
1921 CTAAGTACTGTAATCCACACAACACATTATAAGAAGCAAACCAGCATCTTAAGGAATTATAAAATTACCCTATTTAAAAG
2001 CCATGCTATTGTTCTGCTATTACCAGATTTATTGTGCCACACAAAAGGATCATGTGTGTCAGCAGGGGCCGTTTGGAACA
2081 AACCTAGTCATTAATGAGTAAGATACTCCTGTTAGTTCAGGGACCAAGTTTTATGACCCAGAGGCTTAATGATGTTTGGA
2161 TATATTTCAAATCGGCGTGCTTACCTCACTGATTTAAATTATTTTCTAAATAGTGGCCATTGTAGACCTGACTCAGGCTG
2241 AAGCTAAATAGAGAACAATTTAGAAAGTTAACTAACAATACAGTGCATTCTACCCGTAGGGCCACCATGCCCTTCTGCCC
2321 CTGGCTGATTTGATCCTGTGTCTGATCCCATTGCACCCTGACTGGGCAGTCCCTACAGAACCAGTGTTAATTTGAAGGGC
2401 CTCCACTCAGGCTCCAAATGTGGCAGCCAAAGAGAACAATCCAGGGAACCTACATTTATTTTTAAGGACAAATATTTCCT
2481 CCTCAGTGGTCCTAATGTTCAGGGCTTTAGAGGGAACCCAGGTGGTCTCTTCACCCTGTGTCCTAGAATGGGAGAGTAAG
2561 TAGACAGTGGTGATAACCCCACACTGCTTATAAGTGCATCTTTATAGTATTTGGGGCTTTCCTACCCCTTTAGCCTTCTG
2641 TACCTAGTACCATATTCCAGTTTTAAAGAACTGGCAGAATGTGATGGATAACAGAGGAAGAGCTCAATTTATGTTTATTG
2721 GAAGAACATTTTACTTAAATGATTTGAGGGGTGGGAGGGAGTGAACTACTGAGTTTGCCAGAGTGAAAATCCATCTGAAA
2801 AACTCAGCTACCTTTAGTTTTTAGTCCTCATTTTTGGTCTTGTCTCTGCGGACTGTGAAGAATCACAATGCTCTATATGC
2881 CCTGGACTGTGTGGCAAATGCAGGTTGCAGCGTGTGTGTTACATGAGGATCTTCCACAATTTCAGAATGCACGCCAGAGC
2961 TGAAGGGGGAAACTTGGTAACTTGCCCATTATTCTCTGCTTTTAGCCAGAGTTAAACAGACTGATGGGTCTGGTAGCCAA
3041 CAACTTGGCAACTTCCACTCCTTCTCACCTCGTGAGATTAAGGGCTGTGAAAAGAAATCTAGTCTAACTCCAACAGAAAT
3121 CTGTCTCTGTTAAGTGTTTTACCTTCTGTAAGTAGAGATGGTAGAGCCAAGATTTTTCTTTTGGTAATTTCCCTGTCTAT
3201 AAAGTGAGACCAAAGGGATATCTGTTCCCTGTTACCTTTTTGGAGAATTCATAACATTTGAAGATCAAAAAATTGAATGA
3281 TAAATATGAATGGCTTTTCAATTCTGTGGACTTTGTACCATTTGGCTTCACCTTGTACTGCAAGATGAATTTGTAAACAA
3361 AACAAAATTGGACTGTCTGGAAAGCTAAAGTTCTGAAATATGGAATGTACTGCCTCTAATTTTTCTTTGTCTTCCTCTCA
3441 CTGGCATTTTTTTCTCTCCCAGGTTTCTTAAGAATAATGTTTTTTAAAGGAGGCTTTTTGCCCATCAAGAATAAAAAGAA
3521 ATAAAACCAAAGGGTTACCGGACTTAAGCCCCCGCAGTCACTGTGCGCCATCCCTGAGCAAAGTCCGCCCCTGAGGACAG
3601 TGCCCCTGCCCCAGTGACAGGCCTTACTCCTCCCAGGGCCTTTGCTTCTAATAGGGGGTGGTCTTTCTTTTCTTTCTCTC
3681 CTTTTTTTTTTTTTGATTAAAAAATAAAACCAAACCAGAATTTGCTGAAAGCAGGTACCTTTCAGTAGCTCCGATCAGAG
3761 TAACTCAGCTTAGAGATACTGTTACTCAGGACAACAGTATGTACAAAAGTCTCCGGAAAAGGAAAATAAAACAACCTGAA
3841 AAGAATTCAACTTGAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acCAUGUUUUCAGUAACGGCAa 5'
            | ||: : | ||||||||| 
Target 5' gaGCACGTGTGACATTGCCGTc 3'
 61 - 82 160.00 -14.40
2 
miRNA  3' accauguuuucaGUAACGGCAa 5'
                      ||||||:|| 
Target 5' tgtttcgtttccCATTGCTGTa 3'
 456 - 477 134.00 -10.20
3 
miRNA  3' accaUGUUUUCAGUAACGGCAa 5'
              || :: ||: ||||:|| 
Target 5' ctccACTGGTGTT-TTGCTGTt 3'
 319 - 339 133.00 -9.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30114811 1 COSMIC
COSN30132468 19 COSMIC
COSN30159056 50 COSMIC
COSN30153044 55 COSMIC
COSN30179745 61 COSMIC
COSN30158470 71 COSMIC
COSN30105789 98 COSMIC
COSN30479375 98 COSMIC
COSN31573008 108 COSMIC
COSN30461350 127 COSMIC
COSN30181803 141 COSMIC
COSN31590100 191 COSMIC
COSN31531803 243 COSMIC
COSN20073513 288 COSMIC
COSN20178772 315 COSMIC
COSN31481502 335 COSMIC
COSN212312 362 COSMIC
COSN28757632 374 COSMIC
COSN6010758 446 COSMIC
COSN17182613 571 COSMIC
COSN31561993 598 COSMIC
COSN22832081 603 COSMIC
COSN31544798 976 COSMIC
COSN5358879 1006 COSMIC
COSN28772931 1017 COSMIC
COSN20095638 1170 COSMIC
COSN31578553 1247 COSMIC
COSN31550894 1267 COSMIC
COSN31603625 1285 COSMIC
COSN26643711 1331 COSMIC
COSN22523362 1383 COSMIC
COSN30355830 1459 COSMIC
COSN29855652 1632 COSMIC
COSN1415918 1804 COSMIC
COSN20090418 1812 COSMIC
COSN1415917 2112 COSMIC
COSN31576842 2122 COSMIC
COSN28649159 2177 COSMIC
COSN5358878 2300 COSMIC
COSN24959486 2364 COSMIC
COSN15331666 2537 COSMIC
COSN21676898 2734 COSMIC
COSN16128609 2925 COSMIC
COSN31526878 3072 COSMIC
COSN31546763 3094 COSMIC
COSN26095042 3181 COSMIC
COSN28631942 3212 COSMIC
COSN17928801 3454 COSMIC
COSN28551886 3696 COSMIC
rs1044595 2177 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs759343239 1 dbSNP
rs753729140 2 dbSNP
rs766332699 4 dbSNP
rs200483427 5 dbSNP
rs772642301 7 dbSNP
rs771738421 8 dbSNP
rs1409349298 9 dbSNP
rs1310223872 10 dbSNP
rs1308825371 17 dbSNP
rs1422127135 17 dbSNP
rs547525804 19 dbSNP
rs774151529 20 dbSNP
rs1434911301 28 dbSNP
rs200969874 29 dbSNP
rs371243048 32 dbSNP
rs1039408376 34 dbSNP
rs777248692 35 dbSNP
rs1302494799 36 dbSNP
rs771392450 39 dbSNP
rs1347343822 41 dbSNP
rs367855216 42 dbSNP
rs758513911 45 dbSNP
rs543409439 55 dbSNP
rs531525526 65 dbSNP
rs988041608 66 dbSNP
rs1443103013 67 dbSNP
rs1391618901 69 dbSNP
rs1211804988 74 dbSNP
rs954932508 76 dbSNP
rs1436356459 79 dbSNP
rs534270075 80 dbSNP
rs1052519333 82 dbSNP
rs1410069507 85 dbSNP
rs545993536 88 dbSNP
rs944812265 90 dbSNP
rs890564979 98 dbSNP
rs1393908252 99 dbSNP
rs147562861 111 dbSNP
rs972134944 117 dbSNP
rs1454346364 121 dbSNP
rs1173903629 122 dbSNP
rs553843557 125 dbSNP
rs879230513 129 dbSNP
rs963448616 130 dbSNP
rs755429806 131 dbSNP
rs1356102204 137 dbSNP
rs1387250157 141 dbSNP
rs1325164219 144 dbSNP
rs541603646 148 dbSNP
rs1370262378 153 dbSNP
rs754152143 156 dbSNP
rs1235109737 157 dbSNP
rs1475283875 159 dbSNP
rs753951896 162 dbSNP
rs1337673608 163 dbSNP
rs766702307 165 dbSNP
rs1012898614 168 dbSNP
rs1038290881 169 dbSNP
rs1212305517 170 dbSNP
rs1469356242 171 dbSNP
rs537165812 171 dbSNP
rs1369530961 179 dbSNP
rs958598564 180 dbSNP
rs1200351857 182 dbSNP
rs1474857990 184 dbSNP
rs908411047 184 dbSNP
rs1180320094 191 dbSNP
rs1168166872 195 dbSNP
rs1205260027 198 dbSNP
rs1425440756 208 dbSNP
rs1035651610 222 dbSNP
rs574475196 228 dbSNP
rs960710380 231 dbSNP
rs1395109582 242 dbSNP
rs1003112212 243 dbSNP
rs902982205 244 dbSNP
rs1041947384 245 dbSNP
rs1011308734 248 dbSNP
rs1303935887 248 dbSNP
rs867155815 251 dbSNP
rs1236245052 252 dbSNP
rs1271009014 256 dbSNP
rs200518723 258 dbSNP
rs1231845350 260 dbSNP
rs1273007634 264 dbSNP
rs1336074601 266 dbSNP
rs1039374679 274 dbSNP
rs1259005481 275 dbSNP
rs537825473 280 dbSNP
rs570379556 286 dbSNP
rs750884397 287 dbSNP
rs942381378 288 dbSNP
rs1011192570 292 dbSNP
rs1409048511 294 dbSNP
rs956841633 295 dbSNP
rs1031564404 296 dbSNP
rs1418360547 301 dbSNP
rs1175869581 303 dbSNP
rs910786028 304 dbSNP
rs1156766790 322 dbSNP
rs1382811844 327 dbSNP
rs1051985410 328 dbSNP
rs1298955623 335 dbSNP
rs1342593529 337 dbSNP
rs1413217857 338 dbSNP
rs1293027006 341 dbSNP
rs890504754 348 dbSNP
rs111505920 350 dbSNP
rs1394935890 353 dbSNP
rs919409832 364 dbSNP
rs1349253321 365 dbSNP
rs972217926 366 dbSNP
rs996133300 368 dbSNP
rs963415954 370 dbSNP
rs1471194731 371 dbSNP
rs1186820325 375 dbSNP
rs370168577 379 dbSNP
rs1181326066 388 dbSNP
rs909326361 391 dbSNP
rs1038236994 392 dbSNP
rs1282772606 392 dbSNP
rs991448166 399 dbSNP
rs201397868 401 dbSNP
rs1277810379 402 dbSNP
rs139115118 405 dbSNP
rs1312519278 408 dbSNP
rs566099893 409 dbSNP
rs1277314633 410 dbSNP
rs1408713282 430 dbSNP
rs867257303 434 dbSNP
rs150744249 442 dbSNP
rs1241554694 443 dbSNP
rs1310758701 449 dbSNP
rs1345145231 453 dbSNP
rs939206750 460 dbSNP
rs1280601608 461 dbSNP
rs751833956 462 dbSNP
rs1399747887 472 dbSNP
rs1011446240 489 dbSNP
rs1314338169 490 dbSNP
rs184179179 491 dbSNP
rs1433186560 493 dbSNP
rs1452676779 493 dbSNP
rs1173178602 494 dbSNP
rs1378419504 498 dbSNP
rs1467826017 508 dbSNP
rs192180010 512 dbSNP
rs1006650237 558 dbSNP
rs1396266737 559 dbSNP
rs1160466742 573 dbSNP
rs980585619 577 dbSNP
rs530087658 590 dbSNP
rs1402996575 591 dbSNP
rs1368060387 606 dbSNP
rs914935499 613 dbSNP
rs989164622 613 dbSNP
rs568191059 615 dbSNP
rs764216498 616 dbSNP
rs956913913 625 dbSNP
rs1051221055 629 dbSNP
rs1158021822 637 dbSNP
rs1456156372 642 dbSNP
rs1031260726 648 dbSNP
rs41268450 654 dbSNP
rs1200398890 655 dbSNP
rs898099415 658 dbSNP
rs1468031639 662 dbSNP
rs752522302 663 dbSNP
rs1236719393 666 dbSNP
rs1036469441 667 dbSNP
rs531562089 668 dbSNP
rs909293839 669 dbSNP
rs79356721 695 dbSNP
rs776303201 696 dbSNP
rs1173355604 697 dbSNP
rs937424943 698 dbSNP
rs142936250 699 dbSNP
rs1227175620 702 dbSNP
rs1293577069 708 dbSNP
rs899151158 712 dbSNP
rs928632719 714 dbSNP
rs1380123887 723 dbSNP
rs981864738 732 dbSNP
rs967310208 751 dbSNP
rs139674833 754 dbSNP
rs560139017 755 dbSNP
rs1334044438 758 dbSNP
rs1222256488 759 dbSNP
rs1247314506 760 dbSNP
rs561977062 769 dbSNP
rs1018121500 774 dbSNP
rs1261287317 779 dbSNP
rs1378863667 779 dbSNP
rs373631724 781 dbSNP
rs1433358797 782 dbSNP
rs939178531 787 dbSNP
rs546479342 789 dbSNP
rs1343874647 802 dbSNP
rs1351060781 804 dbSNP
rs1029316927 806 dbSNP
rs994261420 814 dbSNP
rs1340731501 818 dbSNP
rs898075372 829 dbSNP
rs1044820341 830 dbSNP
rs1291166964 834 dbSNP
rs1462014044 844 dbSNP
rs1228755732 848 dbSNP
rs562537078 850 dbSNP
rs915007154 851 dbSNP
rs1285457534 853 dbSNP
rs865888698 854 dbSNP
rs1255793951 855 dbSNP
rs1472684134 861 dbSNP
rs989112481 872 dbSNP
rs1036607029 879 dbSNP
rs1163013502 882 dbSNP
rs934988955 883 dbSNP
rs771759269 901 dbSNP
rs1157707724 905 dbSNP
rs1360652559 911 dbSNP
rs1421088686 917 dbSNP
rs924187223 921 dbSNP
rs747650121 923 dbSNP
rs778696650 929 dbSNP
rs987776388 933 dbSNP
rs1285792066 940 dbSNP
rs1186849747 945 dbSNP
rs1371060022 947 dbSNP
rs1486728129 948 dbSNP
rs1240228584 949 dbSNP
rs1308568894 950 dbSNP
rs942295878 951 dbSNP
rs1354534410 952 dbSNP
rs544250129 962 dbSNP
rs1278466430 964 dbSNP
rs887907817 971 dbSNP
rs3831185 973 dbSNP
rs955032766 975 dbSNP
rs1029184357 983 dbSNP
rs1479926431 988 dbSNP
rs1178603943 992 dbSNP
rs1468538695 998 dbSNP
rs1274551518 999 dbSNP
rs576862799 1006 dbSNP
rs1055909923 1015 dbSNP
rs1171274341 1017 dbSNP
rs1424010009 1018 dbSNP
rs1320694271 1025 dbSNP
rs1414729395 1030 dbSNP
rs937414697 1035 dbSNP
rs1335900058 1043 dbSNP
rs1352572932 1046 dbSNP
rs1441335982 1050 dbSNP
rs928742492 1052 dbSNP
rs1377658952 1053 dbSNP
rs981448816 1053 dbSNP
rs1216630340 1055 dbSNP
rs1301415303 1057 dbSNP
rs1344555288 1060 dbSNP
rs1360384678 1060 dbSNP
rs1281121450 1063 dbSNP
rs1306139474 1075 dbSNP
rs946071530 1087 dbSNP
rs750130571 1088 dbSNP
rs974897887 1088 dbSNP
rs1191177911 1091 dbSNP
rs913242133 1094 dbSNP
rs1016308408 1096 dbSNP
rs990024807 1101 dbSNP
rs1245662141 1114 dbSNP
rs558496665 1116 dbSNP
rs539783860 1123 dbSNP
rs1018090763 1130 dbSNP
rs1417060072 1135 dbSNP
rs886480249 1146 dbSNP
rs186880791 1156 dbSNP
rs1396759807 1157 dbSNP
rs1323939639 1160 dbSNP
rs1330629930 1165 dbSNP
rs1323916868 1168 dbSNP
rs201178383 1170 dbSNP
rs869257128 1170 dbSNP
rs10646851 1171 dbSNP
rs985725006 1173 dbSNP
rs34521831 1174 dbSNP
rs370774465 1174 dbSNP
rs386368888 1174 dbSNP
rs1218395381 1175 dbSNP
rs955132667 1181 dbSNP
rs1003490475 1192 dbSNP
rs1355268638 1194 dbSNP
rs906462298 1196 dbSNP
rs1427763977 1197 dbSNP
rs1288462990 1201 dbSNP
rs1172825638 1208 dbSNP
rs1451693415 1208 dbSNP
rs1430071936 1212 dbSNP
rs1240001217 1215 dbSNP
rs1477326392 1219 dbSNP
rs1194090017 1249 dbSNP
rs554097465 1255 dbSNP
rs1029864796 1259 dbSNP
rs1425560138 1263 dbSNP
rs1459773713 1264 dbSNP
rs993842484 1288 dbSNP
rs368114928 1290 dbSNP
rs960995757 1291 dbSNP
rs1044892801 1313 dbSNP
rs1325677965 1317 dbSNP
rs768199845 1317 dbSNP
rs947877809 1323 dbSNP
rs1254844492 1324 dbSNP
rs1342794913 1333 dbSNP
rs1006405517 1334 dbSNP
rs893521119 1340 dbSNP
rs1211237480 1347 dbSNP
rs1284134448 1358 dbSNP
rs1357762172 1366 dbSNP
rs1211097140 1368 dbSNP
rs888045350 1372 dbSNP
rs1281589456 1373 dbSNP
rs1055878766 1382 dbSNP
rs748917830 1408 dbSNP
rs1053576203 1409 dbSNP
rs934986533 1414 dbSNP
rs923660897 1415 dbSNP
rs1474111391 1418 dbSNP
rs1206259757 1437 dbSNP
rs78566405 1449 dbSNP
rs77724049 1450 dbSNP
rs77044099 1451 dbSNP
rs1368972337 1459 dbSNP
rs200382375 1460 dbSNP
rs763908668 1460 dbSNP
rs1165041952 1463 dbSNP
rs922199575 1470 dbSNP
rs907283931 1478 dbSNP
rs879436123 1483 dbSNP
rs1301887035 1484 dbSNP
rs1362776484 1484 dbSNP
rs1312536617 1486 dbSNP
rs1386225668 1491 dbSNP
rs756435846 1493 dbSNP
rs183132656 1497 dbSNP
rs1277228154 1506 dbSNP
rs1352364908 1509 dbSNP
rs751359473 1510 dbSNP
rs1240350369 1515 dbSNP
rs201825522 1526 dbSNP
rs1287712134 1545 dbSNP
rs913211003 1557 dbSNP
rs950762820 1575 dbSNP
rs1300113340 1579 dbSNP
rs1054471057 1592 dbSNP
rs772705042 1596 dbSNP
rs1199640793 1599 dbSNP
rs1460698433 1600 dbSNP
rs1444024994 1601 dbSNP
rs115208889 1602 dbSNP
rs1167680558 1604 dbSNP
rs1435140798 1606 dbSNP
rs1003299883 1608 dbSNP
rs911164940 1611 dbSNP
rs1196737578 1613 dbSNP
rs985307265 1614 dbSNP
rs1023560093 1621 dbSNP
rs1403396733 1622 dbSNP
rs1250662557 1623 dbSNP
rs570553437 1631 dbSNP
rs1398254883 1632 dbSNP
rs955419934 1636 dbSNP
rs1012086536 1637 dbSNP
rs1375431923 1639 dbSNP
rs1446865010 1656 dbSNP
rs750974208 1660 dbSNP
rs1310042214 1664 dbSNP
rs781654040 1702 dbSNP
rs1256315964 1703 dbSNP
rs114908482 1706 dbSNP
rs1193933397 1711 dbSNP
rs1211959348 1712 dbSNP
rs190938353 1724 dbSNP
rs528239325 1725 dbSNP
rs1458206783 1728 dbSNP
rs116837703 1768 dbSNP
rs1240152558 1771 dbSNP
rs1431615707 1772 dbSNP
rs1175653526 1778 dbSNP
rs1378517104 1779 dbSNP
rs1467906922 1781 dbSNP
rs1489138674 1782 dbSNP
rs1169059592 1785 dbSNP
rs548103933 1796 dbSNP
rs1400180113 1798 dbSNP
rs1448220885 1801 dbSNP
rs1317563333 1802 dbSNP
rs1364900159 1804 dbSNP
rs560915923 1812 dbSNP
rs1389770592 1825 dbSNP
rs952281304 1839 dbSNP
rs1313725013 1841 dbSNP
rs529889905 1844 dbSNP
rs942194647 1845 dbSNP
rs1318474354 1846 dbSNP
rs1377111579 1855 dbSNP
rs1200490380 1863 dbSNP
rs1253103986 1865 dbSNP
rs1001799517 1880 dbSNP
rs909413200 1890 dbSNP
rs542739095 1894 dbSNP
rs1465524713 1897 dbSNP
rs950803498 1902 dbSNP
rs562575336 1910 dbSNP
rs544282415 1912 dbSNP
rs1471326503 1923 dbSNP
rs766128995 1923 dbSNP
rs577001264 1927 dbSNP
rs1250539394 1928 dbSNP
rs1293669817 1930 dbSNP
rs1392407388 1930 dbSNP
rs981427368 1930 dbSNP
rs1397799405 1939 dbSNP
rs1188290443 1947 dbSNP
rs1277292422 1951 dbSNP
rs1340921097 1952 dbSNP
rs970502766 1954 dbSNP
rs1310494294 1961 dbSNP
rs1321120531 2008 dbSNP
rs1220900444 2021 dbSNP
rs1486856588 2023 dbSNP
rs1490890373 2031 dbSNP
rs146351738 2037 dbSNP
rs762613566 2040 dbSNP
rs1214749016 2049 dbSNP
rs760524072 2050 dbSNP
rs1478353757 2054 dbSNP
rs891913715 2060 dbSNP
rs1412242879 2062 dbSNP
rs1423796506 2063 dbSNP
rs1254563877 2066 dbSNP
rs1054441636 2068 dbSNP
rs936024895 2069 dbSNP
rs1012202583 2070 dbSNP
rs911133722 2071 dbSNP
rs564772532 2075 dbSNP
rs1401615146 2082 dbSNP
rs1300925106 2097 dbSNP
rs1378306673 2098 dbSNP
rs75890825 2101 dbSNP
rs1313469736 2106 dbSNP
rs1328644728 2109 dbSNP
rs1361697158 2118 dbSNP
rs922404683 2118 dbSNP
rs1294128589 2133 dbSNP
rs1235410989 2134 dbSNP
rs1285571372 2137 dbSNP
rs1488771275 2138 dbSNP
rs1357103330 2146 dbSNP
rs1218362312 2160 dbSNP
rs1236131595 2162 dbSNP
rs1483188932 2169 dbSNP
rs1182980265 2172 dbSNP
rs1331894389 2173 dbSNP
rs1395270742 2174 dbSNP
rs972605482 2176 dbSNP
rs1044595 2177 dbSNP
rs902225411 2183 dbSNP
rs1455174586 2187 dbSNP
rs1421180466 2207 dbSNP
rs909661718 2210 dbSNP
rs761779283 2215 dbSNP
rs1358385024 2216 dbSNP
rs983750229 2222 dbSNP
rs367601873 2234 dbSNP
rs1165159265 2252 dbSNP
rs1374655605 2269 dbSNP
rs779766412 2277 dbSNP
rs997186717 2287 dbSNP
rs959067036 2292 dbSNP
rs554411366 2295 dbSNP
rs187760793 2296 dbSNP
rs1211357954 2298 dbSNP
rs971683489 2306 dbSNP
rs1024878759 2312 dbSNP
rs1010431811 2320 dbSNP
rs1177444671 2331 dbSNP
rs891882725 2333 dbSNP
rs1207460303 2337 dbSNP
rs1238284634 2347 dbSNP
rs1470930851 2358 dbSNP
rs1464472033 2365 dbSNP
rs1189110964 2367 dbSNP
rs556330462 2370 dbSNP
rs909485328 2377 dbSNP
rs1273940589 2381 dbSNP
rs1414816837 2385 dbSNP
rs1033127921 2394 dbSNP
rs1397994289 2414 dbSNP
rs1465078881 2430 dbSNP
rs1047859516 2434 dbSNP
rs1377778115 2440 dbSNP
rs1000288159 2441 dbSNP
rs537998405 2449 dbSNP
rs981969546 2450 dbSNP
rs1049770950 2457 dbSNP
rs915939809 2469 dbSNP
rs1265444863 2471 dbSNP
rs1316549640 2474 dbSNP
rs933872783 2485 dbSNP
rs1326866879 2489 dbSNP
rs570590740 2496 dbSNP
rs1258076626 2497 dbSNP
rs1439047297 2504 dbSNP
rs1037256144 2516 dbSNP
rs1196210597 2518 dbSNP
rs1245753227 2521 dbSNP
rs184008893 2524 dbSNP
rs1478178328 2528 dbSNP
rs939898117 2531 dbSNP
rs977909837 2536 dbSNP
rs909629293 2566 dbSNP
rs1432864318 2578 dbSNP
rs563924394 2583 dbSNP
rs773750040 2588 dbSNP
rs937780010 2590 dbSNP
rs760126094 2591 dbSNP
rs1321734472 2594 dbSNP
rs768168276 2604 dbSNP
rs1437509092 2607 dbSNP
rs1030073598 2609 dbSNP
rs981826782 2610 dbSNP
rs1338916757 2611 dbSNP
rs190857720 2612 dbSNP
rs748929068 2626 dbSNP
rs1024599001 2636 dbSNP
rs988970072 2640 dbSNP
rs956157387 2644 dbSNP
rs1288573102 2660 dbSNP
rs1005851291 2668 dbSNP
rs535031739 2684 dbSNP
rs1033181887 2687 dbSNP
rs887991534 2688 dbSNP
rs1048490350 2689 dbSNP
rs372588739 2700 dbSNP
rs1487844755 2704 dbSNP
rs929483572 2711 dbSNP
rs1374712203 2712 dbSNP
rs1000258679 2713 dbSNP
rs779731288 2717 dbSNP
rs1375179131 2718 dbSNP
rs1161505843 2735 dbSNP
rs1045799299 2736 dbSNP
rs1425471687 2737 dbSNP
rs1305192019 2749 dbSNP
rs1358940788 2758 dbSNP
rs1399765556 2768 dbSNP
rs889891174 2778 dbSNP
rs1166756121 2779 dbSNP
rs1319444215 2780 dbSNP
rs1328673491 2793 dbSNP
rs1243290011 2795 dbSNP
rs948760781 2796 dbSNP
rs1356457669 2805 dbSNP
rs868824471 2807 dbSNP
rs1283440456 2810 dbSNP
rs1254209920 2823 dbSNP
rs998222417 2844 dbSNP
rs1217041836 2845 dbSNP
rs1263636317 2846 dbSNP
rs568585439 2849 dbSNP
rs1186765352 2850 dbSNP
rs1449952950 2853 dbSNP
rs1036944838 2855 dbSNP
rs1378670609 2862 dbSNP
rs1419369249 2863 dbSNP
rs935988639 2866 dbSNP
rs1196670679 2868 dbSNP
rs866797722 2869 dbSNP
rs1394745406 2871 dbSNP
rs770199988 2873 dbSNP
rs746224433 2875 dbSNP
rs1339794466 2893 dbSNP
rs1276571198 2894 dbSNP
rs925218333 2901 dbSNP
rs74739514 2903 dbSNP
rs978445586 2911 dbSNP
rs937742266 2912 dbSNP
rs1352490091 2917 dbSNP
rs1030603140 2918 dbSNP
rs1262209614 2923 dbSNP
rs781467704 2929 dbSNP
rs1442398673 2938 dbSNP
rs118070745 2939 dbSNP
rs186515784 2947 dbSNP
rs1322428054 2948 dbSNP
rs142266195 2952 dbSNP
rs1017311458 2953 dbSNP
rs532270767 2963 dbSNP
rs767842061 2965 dbSNP
rs199799600 2969 dbSNP
rs1439262651 2972 dbSNP
rs887475466 2988 dbSNP
rs989022527 2999 dbSNP
rs956294436 3007 dbSNP
rs926081644 3021 dbSNP
rs1464855658 3027 dbSNP
rs978954896 3028 dbSNP
rs1429515424 3032 dbSNP
rs1396151217 3033 dbSNP
rs954254010 3038 dbSNP
rs1407453553 3040 dbSNP
rs1471267907 3050 dbSNP
rs1196118231 3053 dbSNP
rs1477079176 3058 dbSNP
rs765017312 3068 dbSNP
rs1028449677 3069 dbSNP
rs994181761 3071 dbSNP
rs998587719 3072 dbSNP
rs1329049834 3074 dbSNP
rs1232225326 3075 dbSNP
rs759956966 3081 dbSNP
rs1325541801 3087 dbSNP
rs1015565279 3096 dbSNP
rs1256172079 3108 dbSNP
rs1457375192 3113 dbSNP
rs948871631 3115 dbSNP
rs894522851 3119 dbSNP
rs1054581959 3122 dbSNP
rs1198564180 3126 dbSNP
rs76838636 3127 dbSNP
rs1341218922 3131 dbSNP
rs144256473 3137 dbSNP
rs866360632 3156 dbSNP
rs149562517 3159 dbSNP
rs1462035219 3175 dbSNP
rs1220910599 3179 dbSNP
rs978016073 3191 dbSNP
rs945260955 3199 dbSNP
rs542075962 3215 dbSNP
rs1273678394 3216 dbSNP
rs1347175417 3228 dbSNP
rs182920164 3229 dbSNP
rs964556017 3231 dbSNP
rs1046112806 3249 dbSNP
rs1228218186 3250 dbSNP
rs1305811226 3267 dbSNP
rs777744737 3272 dbSNP
rs758473479 3280 dbSNP
rs951729269 3301 dbSNP
rs752910749 3304 dbSNP
rs1490940969 3314 dbSNP
rs913547710 3317 dbSNP
rs1192021312 3325 dbSNP
rs1176043870 3330 dbSNP
rs1413315608 3332 dbSNP
rs190781131 3335 dbSNP
rs765544603 3338 dbSNP
rs1457044533 3340 dbSNP
rs1303382044 3351 dbSNP
rs544385562 3353 dbSNP
rs1026378703 3356 dbSNP
rs774577024 3358 dbSNP
rs1425112354 3371 dbSNP
rs1297407411 3373 dbSNP
rs1318088622 3377 dbSNP
rs1159181529 3390 dbSNP
rs993193059 3391 dbSNP
rs577282388 3395 dbSNP
rs934886962 3401 dbSNP
rs1181785107 3404 dbSNP
rs1292757629 3406 dbSNP
rs1361921550 3408 dbSNP
rs756041061 3414 dbSNP
rs926216684 3418 dbSNP
rs559899151 3428 dbSNP
rs978925475 3433 dbSNP
rs954274236 3443 dbSNP
rs1440564913 3454 dbSNP
rs1277871349 3465 dbSNP
rs1223808185 3473 dbSNP
rs972024188 3493 dbSNP
rs750250429 3494 dbSNP
rs767366048 3502 dbSNP
rs921441237 3504 dbSNP
rs1024564168 3518 dbSNP
rs558984854 3520 dbSNP
rs976826087 3522 dbSNP
rs965857466 3527 dbSNP
rs1356489988 3534 dbSNP
rs138235847 3539 dbSNP
rs1301020856 3540 dbSNP
rs1446284100 3541 dbSNP
rs774308988 3553 dbSNP
rs763558183 3554 dbSNP
rs566820465 3557 dbSNP
rs554991495 3559 dbSNP
rs952626774 3562 dbSNP
rs1238276204 3563 dbSNP
rs1409895301 3566 dbSNP
rs775069498 3567 dbSNP
rs1026891501 3574 dbSNP
rs141614914 3583 dbSNP
rs1218462461 3585 dbSNP
rs903285289 3586 dbSNP
rs1002537925 3590 dbSNP
rs569149519 3596 dbSNP
rs1244481848 3599 dbSNP
rs1420302872 3603 dbSNP
rs550825391 3604 dbSNP
rs1408362458 3610 dbSNP
rs80114793 3614 dbSNP
rs1402218188 3622 dbSNP
rs904986379 3623 dbSNP
rs1173750874 3630 dbSNP
rs923179700 3632 dbSNP
rs1040303194 3638 dbSNP
rs1337415200 3639 dbSNP
rs1408406745 3646 dbSNP
rs943194054 3655 dbSNP
rs1279182124 3656 dbSNP
rs1374408010 3663 dbSNP
rs910410873 3664 dbSNP
rs1046676990 3667 dbSNP
rs532311369 3672 dbSNP
rs1216461219 3677 dbSNP
rs1465858698 3679 dbSNP
rs76111874 3682 dbSNP
rs1323403889 3683 dbSNP
rs1400220427 3684 dbSNP
rs1233073224 3695 dbSNP
rs1264402428 3695 dbSNP
rs1302320900 3695 dbSNP
rs372906189 3695 dbSNP
rs386368887 3695 dbSNP
rs925518648 3696 dbSNP
rs1207570655 3697 dbSNP
rs1334999731 3699 dbSNP
rs919022773 3701 dbSNP
rs571275492 3706 dbSNP
rs1013308813 3726 dbSNP
rs1178505789 3727 dbSNP
rs1398106991 3735 dbSNP
rs892249479 3736 dbSNP
rs1052084479 3738 dbSNP
rs1314467357 3742 dbSNP
rs1444677047 3745 dbSNP
rs1292101437 3747 dbSNP
rs1345294799 3748 dbSNP
rs763249474 3752 dbSNP
rs926187032 3753 dbSNP
rs1311883885 3762 dbSNP
rs745463829 3764 dbSNP
rs867345942 3769 dbSNP
rs932901282 3777 dbSNP
rs921411967 3785 dbSNP
rs977351403 3791 dbSNP
rs944105910 3792 dbSNP
rs1273131630 3799 dbSNP
rs77864872 3800 dbSNP
rs1218944606 3801 dbSNP
rs528083105 3806 dbSNP
rs370893196 3811 dbSNP
rs776470567 3814 dbSNP
rs771244822 3825 dbSNP
rs1026945795 3832 dbSNP
rs1387111488 3843 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' accauguuuucaGUAACGGCAa 5'
                      ||||||||| 
Target 5' -----------aCAUUGCCGUc 3'
 		1 - 11
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000258301.5 | 3UTR | ACAUUGCCGUCUACUCACAUUCCUAUCCUGGAAACAUACUGCUGCACUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
15 hsa-miR-548al Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT100248 MRPS18B mitochondrial ribosomal protein S18B 2 2
MIRT466864 STX6 syntaxin 6 2 2
MIRT472971 MSANTD3 Myb/SANT DNA binding domain containing 3 2 2
MIRT477531 EIF4G2 eukaryotic translation initiation factor 4 gamma 2 2 5
MIRT483200 PIP4K2A phosphatidylinositol-5-phosphate 4-kinase type 2 alpha 2 2
MIRT496727 NKD2 naked cuticle homolog 2 2 2
MIRT504947 ZNRF2 zinc and ring finger 2 2 6
MIRT529248 TRIM4 tripartite motif containing 4 2 2
MIRT529477 THUMPD3 THUMP domain containing 3 2 2
MIRT576335 Rapgefl1 Rap guanine nucleotide exchange factor (GEF)-like 1 2 5
MIRT607473 RAPGEFL1 Rap guanine nucleotide exchange factor like 1 2 7
MIRT629228 FAM186A family with sequence similarity 186 member A 2 2
MIRT651501 WT1 Wilms tumor 1 2 2
MIRT662296 SLC29A4 solute carrier family 29 member 4 2 2
MIRT688897 C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-54 Nicotine approved 89594 Microarray Caenorhabditis elegans 23765240 2013 up-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-548al Doxorubicin 31703 NSC123127 approved sensitive cell line (W1)
hsa-mir-548al Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-548al Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-548al Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-548al Tamoxifen+Fulvestrant resistant cell line (LCC9)
hsa-miR-548al Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-548al Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-548al Cisplatin 5460033 NSC119875 approved resistant cell line (MGC-803)
hsa-miR-548al Vemurafenib 42611257 NSC761431 approved resistant cell line (LM16)

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