miRTarBase - #MIRT467475


—
pre-miRNA Information
pre-miRNA hsa-mir-4534   
Genomic Coordinates chr22: 37988794 - 37988853
Description Homo sapiens miR-4534 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4534
Sequence 36| GGAUGGAGGAGGGGUCU |52
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs890798116 2 dbSNP
rs1382774432 11 dbSNP
rs982883970 15 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SMYD1   
Synonyms BOP, KMT3D, ZMYND18, ZMYND22
Description SET and MYND domain containing 1
Transcript NM_198274   
Expression
Putative miRNA Targets on SMYD1
3'UTR of SMYD1
(miRNA target sites are highlighted)		 
>SMYD1|NM_198274|3'UTR
   1 GGACTGCCCAGTGGAGGAGGGGCGATGTGGCTGGGGAGCTAGGGAGAGACTCTGGAGGTGGTGGGTCTCTCGGGAGACCC
  81 CTAATGAGGAAGTTGAGGTAATGCTTAACATTGTTGCTGTGAGAATTTACTGCCCTATGTTTCCCAGAGCCATTTTGGCT
 161 CAATTCAAGTCTATTCAATTCAAGTTAACTCTAGCCCAGCCCAGATCAACTCCTCCTACAAATATTATTGGATGATAGGC
 241 CCTAGAACCCAATAAAGGAGCTCCAAATGTCGTTGGGTGGGGAAGCAAAATGTAGAGAAACATTTAAAGCACACTGTAAT
 321 AATAAATGCAATTATAAACTATATGGAGGAGGGTGCAGAGGAGGGAATGTGTCTGGTGTGTGATGTGTGTGTGTGCAGTG
 401 GGGGTATCACAGAGAGTATGACATCTGAGTTGAGGGTAGCAGGTGCCTGGAGTCTCAGGTGGCTGCTCACCCATCTGTGC
 481 AGGTGTCTCTGGGGCTGCTGGTCTCACCTGTGGTCTGCAGTAGACACAATTGGCTGAGCAGGATATGTGATACTGTGTGG
 561 TTGGTGTGGAGTTTTGAAGAAGGGGCTGTGTTTGGGCCACGTAGGCTCTACTCAGAGACCTGAAACCACTTCAGAATGGT
 641 GCATATGTCGAAAGAGCTGGCTGGGGGCCTTGCCCAAACCAACTGAGGTCTTAAAGTCCAGGGAAAAAAAGTCTGGGTTC
 721 CAACTAGAATTCTAGAAATATTTCTAGAACACACAGAGAGGGAATAAGTCCCTCTATCACCCTTATTACCAAGCCTTGTG
 801 GTTCCCTGTGATTTTAGATAATGTCTGATATTTTTCTGGCTATTTGCCTAGTAGGATTTAAAAAATATTTTCAAAGTGAA
 881 GCTGAGAGAGAATCTTGGAAACACACATACCTGTTGATCATGGGCCCTGCAGAATTGGCCCTTGGGGGCTTTATTTGGTT
 961 ACATGTGCCTGGGTGGTCTTTACCAGCTTAGACTCTATCATGGGCCCCCATGAAGCTCCATTCTCAATACTGAATAATTA
1041 TTACTTCCCTTGTTGAGTTTCTTTTTCTGTCATGCCCTGGGGGCTTCTGCTCTTCTCACCAGAAAGAACATTTGAATCTG
1121 GATTCTTGTACACCTGGGTTAGACCCTGTTCAGAGGTGTGGCCAATTTATCCCGATCTCCTGGAAGGCTGTTGTGATTTC
1201 CATCTAAGAAATGAGGGTCTTGAGAATCAACCAGTCCCAAGATTAGCCTGTTATCCTGTTATCTACTGAGACCCCAAATT
1281 TCTCACCAATGTTTTGGGAGATCCTGGAAAAGATCCCTTCAGTTTGGGGTGTCACCAAGACTTCTACACAACCCAGGACT
1361 ACCATTGACCTCAGAGCTGTACCCCACATCTTGAAGTAAATTGATCCCACCAGGTCCCACGTTTGTTATCTCTGCCTAAA
1441 TGTTAGCTTCTCCATCCTCACCACATGATGACCTGCTGTGTCCCTCTGAGCACTACCCAGTGGCTGAAAACTCTGCAAAT
1521 GGGCCACACTTTTGCAAAATACTTGTATCTGACACTTAGGTCTTGTTTGAAGAATTTCCTTTCTGGAAGGTTTTACAAGA
1601 AGACTGATAGTCTTTCAAGCCCCCACATCACAGGCTTAGGGACGGCACTAACTTTCTCCCAGGGATCTAACTGGCTAGTT
1681 CAAATTATCACTCTTTTACCTTCATATAAAATGTCTCCCCCAAACCTTTTTCCCTTCTTTGTCATTGTTATCTGCTAAGC
1761 CCCTGGTCATTTCCCCATATTCGTAGTCTTTTTTTCCATCCTATCTTTCTAATATTTGTTGTCTTTAACAAACTGTGTTC
1841 TGTGTCTGTGCTCCTCCTTCCCTCTCAGACCACTGGAATGCAAGTCCTTCTTCCCTTTGGAATGTACTCTGGATCCCTTC
1921 CCCTGCTTTGACCCCCAGACTTTGCTCCATCTATTATTGCTTCTCCATCCTGGATCCTTGACATTTGTCACCCCACTGGC
2001 CTTCTCAGGTGCAATCAGTAAAAATGCTGAGAACTCTTGGATCTTAATCTTCATGACTGAGTTTTTTTTAGTTGTATAGT
2081 TATCATCTGCCTTTCTTCACTTTGCATTTCTTCTTGAATCCATTGCAGATTGACTTCCACTCCCACTCCTTCACTAAAAG
2161 GGCTCTTACCAAGATCAAATCTAATGGGTACATTTTAGTTCCTATGTGATTTGGCCTTTCGATGTCAATCATCACTCCCA
2241 GCCATTGATTTTGGTGACCCACTTCCCTGTGATGATCTTCTGATCTAGTTTCTCAGGTTCCTTCGCTGGTCCTTTTTCTT
2321 TCCCTGCCCCTGACATATTGACATTTCCTGGAGTTGGTTTTGTCCTTGATTCATTCTCATGTCATTCTGCACACAGTCTC
2401 TGCATGAACTCAGGCAGACCCTTCATTTAATGACCACCTTAGGGCTGATGATTCTCAAATCTGTATTCCCCGATCTTGCA
2481 TTTGAGCTCCAGCCCCACTCATCCTCTCGGATGTTCTGCAGGCCCAGCAAACTCATCATGTCCAAAGTGAAACTTTTTCT
2561 CTTTCCTGTCTCCTCTCCTCTGATCTGTTCTTTCTTGGAACACCACCCAAGAACGTCACCTCCTCCATCAGATTGTGAGC
2641 TCCTGGAGGGCAGGAGCTGTGTCCTTCTATTCATCTTCCTATCCCCAGAACCTTGCACAGATCCTGGAATGTGGTAGGTG
2721 CTCAGTAAATGTGTGTTGAATAAATGAATGAATGAATGAACAAATGAATGAATTTGCTTACTTCAAGGCAAAAGAACCAT
2801 GAAACTGTATTTTGAGTTTCTATGTTATAGCAGTCAGCAAATCCTATTAAATACTTTGTGTTTCCAAGCAAAAAAAAAAA
2881 AAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucuGGGGAGGAGGUAGg 5'
             | ||||||||||| 
Target 5' cgtCACCTCCTCCATCa 3'
 2614 - 2630 162.00 -22.50
2 
miRNA  3' ucUGGGGAGGAGGUAGg 5'
            |:: ||:||||||| 
Target 5' ttATTGCTTCTCCATCc 3'
 1954 - 1970 155.00 -20.00
3 
miRNA  3' ucugggGAGGAGGUAGg 5'
                ||:||||||| 
Target 5' tgttagCTTCTCCATCc 3'
 1441 - 1457 151.00 -19.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM6858561 1 COSMIC
COSN30536589 23 COSMIC
COSN30140616 24 COSMIC
COSN31602411 25 COSMIC
COSN30611068 44 COSMIC
COSN31496545 51 COSMIC
COSN1861815 58 COSMIC
COSN28670855 72 COSMIC
COSN31958583 74 COSMIC
COSN30133698 77 COSMIC
COSN30133744 78 COSMIC
COSN6685308 138 COSMIC
COSN21242953 273 COSMIC
COSN14515270 405 COSMIC
COSN25389778 568 COSMIC
COSN17190547 606 COSMIC
COSN24371210 1277 COSMIC
COSN21665759 1358 COSMIC
COSN31486070 1377 COSMIC
COSN9392128 1419 COSMIC
COSN30086457 1422 COSMIC
COSN31595263 1467 COSMIC
COSN31593578 1473 COSMIC
COSN8868384 1575 COSMIC
COSN30539866 1579 COSMIC
COSN26897747 1587 COSMIC
COSN28784585 1605 COSMIC
COSN31489926 1644 COSMIC
COSN17076487 1656 COSMIC
COSN14011661 1664 COSMIC
COSN14842987 1766 COSMIC
COSN9392129 1863 COSMIC
COSN5962135 1902 COSMIC
COSN18888538 2009 COSMIC
COSN1861816 2020 COSMIC
COSN5962136 2177 COSMIC
COSN5962137 2221 COSMIC
COSN20738229 2331 COSMIC
COSN22384748 2485 COSMIC
COSN32097748 2643 COSMIC
COSN1861817 2686 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs538751929 2 dbSNP
rs1185564942 6 dbSNP
rs1478186617 7 dbSNP
rs1247891436 8 dbSNP
rs1233078674 10 dbSNP
rs779262564 12 dbSNP
rs1181169773 15 dbSNP
rs750307400 16 dbSNP
rs199889323 17 dbSNP
rs765404188 18 dbSNP
rs752786219 22 dbSNP
rs149175661 23 dbSNP
rs202241112 24 dbSNP
rs1355282542 25 dbSNP
rs1444470035 27 dbSNP
rs1271397384 34 dbSNP
rs752050855 36 dbSNP
rs1257268281 38 dbSNP
rs757829432 39 dbSNP
rs951760136 43 dbSNP
rs1345983395 45 dbSNP
rs1247440654 46 dbSNP
rs898207285 49 dbSNP
rs1317739009 51 dbSNP
rs1403201850 53 dbSNP
rs561539762 59 dbSNP
rs1478508919 61 dbSNP
rs572893051 63 dbSNP
rs1368460736 71 dbSNP
rs2289497 72 dbSNP
rs1426872171 75 dbSNP
rs1170245014 78 dbSNP
rs1002803849 79 dbSNP
rs1411668283 81 dbSNP
rs1332645182 89 dbSNP
rs975816314 92 dbSNP
rs769693575 93 dbSNP
rs1445211407 98 dbSNP
rs1231466624 102 dbSNP
rs958735348 112 dbSNP
rs1306139845 116 dbSNP
rs921710421 117 dbSNP
rs931720470 120 dbSNP
rs1021620209 122 dbSNP
rs564706041 128 dbSNP
rs1289125693 134 dbSNP
rs1230094973 135 dbSNP
rs2289498 138 dbSNP
rs977457371 141 dbSNP
rs1448515840 153 dbSNP
rs112705385 155 dbSNP
rs1360733672 157 dbSNP
rs1334251848 164 dbSNP
rs914409806 171 dbSNP
rs1219994288 181 dbSNP
rs1258134851 190 dbSNP
rs1473834872 192 dbSNP
rs924810971 193 dbSNP
rs933464713 195 dbSNP
rs1473310430 205 dbSNP
rs1239644979 219 dbSNP
rs1457291219 223 dbSNP
rs1461050987 227 dbSNP
rs143286563 243 dbSNP
rs749077335 245 dbSNP
rs139035581 246 dbSNP
rs1315009269 248 dbSNP
rs77720228 262 dbSNP
rs938639155 265 dbSNP
rs548095343 268 dbSNP
rs942390424 270 dbSNP
rs772174026 272 dbSNP
rs113591586 273 dbSNP
rs931081347 275 dbSNP
rs1478918144 278 dbSNP
rs775515588 297 dbSNP
rs1027572437 298 dbSNP
rs1450967495 304 dbSNP
rs1344128415 325 dbSNP
rs566461663 330 dbSNP
rs183050883 337 dbSNP
rs887250861 342 dbSNP
rs1046816576 354 dbSNP
rs1182142459 359 dbSNP
rs1328464331 367 dbSNP
rs879691420 368 dbSNP
rs547017588 371 dbSNP
rs1444196253 373 dbSNP
rs1248910626 374 dbSNP
rs1190809142 384 dbSNP
rs1391906445 384 dbSNP
rs1260287668 392 dbSNP
rs886959290 394 dbSNP
rs571540115 395 dbSNP
rs1019842805 397 dbSNP
rs1245002012 405 dbSNP
rs1365722171 407 dbSNP
rs147434831 410 dbSNP
rs975750811 415 dbSNP
rs1028609502 417 dbSNP
rs558657803 430 dbSNP
rs1293616706 437 dbSNP
rs1458809326 438 dbSNP
rs1368042290 439 dbSNP
rs1162009586 440 dbSNP
rs953171994 448 dbSNP
rs1424403431 451 dbSNP
rs894416099 461 dbSNP
rs1172800163 464 dbSNP
rs566944083 472 dbSNP
rs372754620 473 dbSNP
rs1012834273 476 dbSNP
rs1489394107 480 dbSNP
rs914397354 482 dbSNP
rs968736846 493 dbSNP
rs1342594898 502 dbSNP
rs1276577165 525 dbSNP
rs575934665 531 dbSNP
rs977758804 534 dbSNP
rs1306563711 540 dbSNP
rs1031694902 541 dbSNP
rs187572239 544 dbSNP
rs13432065 545 dbSNP
rs987568574 546 dbSNP
rs576418368 552 dbSNP
rs1301807948 554 dbSNP
rs1356804242 555 dbSNP
rs1209085336 556 dbSNP
rs141776889 559 dbSNP
rs1489418885 561 dbSNP
rs1194633472 562 dbSNP
rs564937376 564 dbSNP
rs1372741718 565 dbSNP
rs1177118957 577 dbSNP
rs894475239 587 dbSNP
rs191832009 589 dbSNP
rs1262604128 591 dbSNP
rs1198579948 592 dbSNP
rs931395414 597 dbSNP
rs1252320740 598 dbSNP
rs1048447392 601 dbSNP
rs887294379 603 dbSNP
rs1480081089 606 dbSNP
rs919597971 612 dbSNP
rs1320791108 613 dbSNP
rs1004409995 617 dbSNP
rs1020188899 619 dbSNP
rs901468572 644 dbSNP
rs997052926 650 dbSNP
rs1028619393 651 dbSNP
rs1331235088 655 dbSNP
rs1387564970 661 dbSNP
rs879229076 663 dbSNP
rs953015365 667 dbSNP
rs1403922951 669 dbSNP
rs1175799360 672 dbSNP
rs1472852967 673 dbSNP
rs543738120 676 dbSNP
rs1401484749 681 dbSNP
rs1298387752 696 dbSNP
rs1021350987 697 dbSNP
rs1256685532 700 dbSNP
rs150572228 700 dbSNP
rs1441640 701 dbSNP
rs894291130 703 dbSNP
rs1314232862 704 dbSNP
rs1330664010 704 dbSNP
rs928443338 705 dbSNP
rs1237612999 708 dbSNP
rs938617713 711 dbSNP
rs991372395 715 dbSNP
rs776831595 716 dbSNP
rs1454716872 724 dbSNP
rs139565992 725 dbSNP
rs1355528564 753 dbSNP
rs1457818817 760 dbSNP
rs1387290965 761 dbSNP
rs1156743142 770 dbSNP
rs998774798 775 dbSNP
rs1217625874 776 dbSNP
rs559910660 777 dbSNP
rs931308929 778 dbSNP
rs1442354551 780 dbSNP
rs1048858548 795 dbSNP
rs908654850 797 dbSNP
rs1448217879 799 dbSNP
rs527618698 801 dbSNP
rs1203839775 802 dbSNP
rs762042923 805 dbSNP
rs1008916418 818 dbSNP
rs1292907036 827 dbSNP
rs1018216163 843 dbSNP
rs1381107970 846 dbSNP
rs765835802 856 dbSNP
rs750973419 862 dbSNP
rs964877310 866 dbSNP
rs974080482 873 dbSNP
rs1328266562 874 dbSNP
rs940092828 877 dbSNP
rs1041236398 878 dbSNP
rs1185983507 879 dbSNP
rs1316332687 891 dbSNP
rs1381514043 891 dbSNP
rs920816486 897 dbSNP
rs1165187855 907 dbSNP
rs1242771541 908 dbSNP
rs901310158 911 dbSNP
rs1382589892 912 dbSNP
rs1384450890 926 dbSNP
rs1168823404 928 dbSNP
rs997062686 929 dbSNP
rs1476194858 933 dbSNP
rs1420623462 936 dbSNP
rs1191881605 937 dbSNP
rs1446877023 938 dbSNP
rs1158888338 939 dbSNP
rs1225421628 948 dbSNP
rs1291581497 949 dbSNP
rs1357735290 949 dbSNP
rs552144766 950 dbSNP
rs982478588 958 dbSNP
rs1268455937 959 dbSNP
rs1441641 964 dbSNP
rs1331791026 972 dbSNP
rs1304871779 977 dbSNP
rs538630471 994 dbSNP
rs1402270854 1008 dbSNP
rs1395410087 1011 dbSNP
rs938436203 1016 dbSNP
rs1011263646 1018 dbSNP
rs1416974305 1029 dbSNP
rs1357323807 1044 dbSNP
rs1021695401 1045 dbSNP
rs1478053210 1053 dbSNP
rs1430878813 1058 dbSNP
rs1202210882 1069 dbSNP
rs915743384 1070 dbSNP
rs1268549196 1078 dbSNP
rs1205702357 1079 dbSNP
rs1378852070 1080 dbSNP
rs967186032 1086 dbSNP
rs1439729646 1110 dbSNP
rs1271122803 1111 dbSNP
rs1240669055 1112 dbSNP
rs1214271230 1121 dbSNP
rs1324353658 1127 dbSNP
rs999006472 1129 dbSNP
rs1285282483 1131 dbSNP
rs1308247975 1136 dbSNP
rs1035523377 1153 dbSNP
rs1279868415 1155 dbSNP
rs959835333 1156 dbSNP
rs766792258 1162 dbSNP
rs948558243 1164 dbSNP
rs1414740648 1166 dbSNP
rs1043370870 1170 dbSNP
rs1173646034 1173 dbSNP
rs991424756 1174 dbSNP
rs915856432 1175 dbSNP
rs1256684759 1178 dbSNP
rs998723884 1187 dbSNP
rs952727411 1188 dbSNP
rs1053090818 1189 dbSNP
rs1204017867 1193 dbSNP
rs1461941467 1195 dbSNP
rs984173666 1204 dbSNP
rs1199252129 1214 dbSNP
rs890440202 1223 dbSNP
rs1008947438 1230 dbSNP
rs1440834284 1237 dbSNP
rs908536239 1240 dbSNP
rs1017663374 1246 dbSNP
rs1178484628 1251 dbSNP
rs1370895048 1252 dbSNP
rs940122929 1255 dbSNP
rs1041074160 1258 dbSNP
rs900668887 1262 dbSNP
rs1278755070 1263 dbSNP
rs35334236 1275 dbSNP
rs374853016 1286 dbSNP
rs1416992917 1289 dbSNP
rs1384589704 1290 dbSNP
rs1334066629 1304 dbSNP
rs1468815998 1308 dbSNP
rs13393820 1311 dbSNP
rs1345314878 1312 dbSNP
rs932797776 1315 dbSNP
rs1402964058 1318 dbSNP
rs569408895 1325 dbSNP
rs4972177 1327 dbSNP
rs1245173521 1330 dbSNP
rs1465055852 1342 dbSNP
rs983685995 1347 dbSNP
rs1015298171 1348 dbSNP
rs1242834923 1350 dbSNP
rs959666361 1352 dbSNP
rs993006235 1357 dbSNP
rs915626679 1358 dbSNP
rs1246473343 1363 dbSNP
rs1361393369 1386 dbSNP
rs574108243 1388 dbSNP
rs1451536379 1389 dbSNP
rs1361965998 1409 dbSNP
rs1290117804 1413 dbSNP
rs1433449582 1417 dbSNP
rs1011566155 1418 dbSNP
rs183904732 1421 dbSNP
rs1387544940 1422 dbSNP
rs1161890351 1436 dbSNP
rs149705283 1437 dbSNP
rs1262436251 1445 dbSNP
rs1188391768 1449 dbSNP
rs1330485682 1451 dbSNP
rs902806265 1454 dbSNP
rs1484826942 1457 dbSNP
rs934605532 1465 dbSNP
rs1052936460 1468 dbSNP
rs890473962 1473 dbSNP
rs534507737 1474 dbSNP
rs1231233247 1482 dbSNP
rs1260070513 1483 dbSNP
rs944682851 1485 dbSNP
rs1212274111 1492 dbSNP
rs146199411 1493 dbSNP
rs561413187 1496 dbSNP
rs1236758764 1511 dbSNP
rs1367785924 1514 dbSNP
rs1489649382 1521 dbSNP
rs1192580768 1530 dbSNP
rs1373883326 1531 dbSNP
rs1172876091 1536 dbSNP
rs576787266 1540 dbSNP
rs1337914171 1541 dbSNP
rs139105051 1543 dbSNP
rs1273311554 1548 dbSNP
rs535053013 1560 dbSNP
rs1027846340 1561 dbSNP
rs1266452530 1562 dbSNP
rs1439122675 1566 dbSNP
rs755742960 1568 dbSNP
rs2919865 1575 dbSNP
rs1005151458 1579 dbSNP
rs1389683953 1581 dbSNP
rs1035248868 1582 dbSNP
rs1185383916 1585 dbSNP
rs1286941687 1586 dbSNP
rs1347970737 1586 dbSNP
rs1281720941 1596 dbSNP
rs748764592 1606 dbSNP
rs1397713746 1607 dbSNP
rs1474971453 1609 dbSNP
rs1168241105 1614 dbSNP
rs574236903 1616 dbSNP
rs768292668 1617 dbSNP
rs1295046497 1620 dbSNP
rs1467436461 1621 dbSNP
rs1334967401 1625 dbSNP
rs1405492241 1627 dbSNP
rs1453446290 1631 dbSNP
rs1339297264 1632 dbSNP
rs959697457 1634 dbSNP
rs1012786555 1635 dbSNP
rs1022798112 1641 dbSNP
rs189025545 1644 dbSNP
rs774059828 1645 dbSNP
rs1341894253 1648 dbSNP
rs35181910 1661 dbSNP
rs969875533 1678 dbSNP
rs978902990 1692 dbSNP
rs961645422 1695 dbSNP
rs1222853726 1696 dbSNP
rs1175061053 1704 dbSNP
rs976822644 1705 dbSNP
rs922711576 1706 dbSNP
rs1263175587 1707 dbSNP
rs527439750 1716 dbSNP
rs1320865501 1720 dbSNP
rs985625590 1725 dbSNP
rs755687265 1726 dbSNP
rs946989738 1727 dbSNP
rs1309608020 1730 dbSNP
rs1389847978 1733 dbSNP
rs1042997166 1738 dbSNP
rs1337692902 1738 dbSNP
rs1470978436 1740 dbSNP
rs1404085126 1741 dbSNP
rs902869233 1742 dbSNP
rs1171911289 1744 dbSNP
rs1454258654 1747 dbSNP
rs777621255 1761 dbSNP
rs2970888 1763 dbSNP
rs930774663 1766 dbSNP
rs1049146676 1767 dbSNP
rs564193492 1776 dbSNP
rs886626198 1779 dbSNP
rs895603774 1783 dbSNP
rs370611091 1784 dbSNP
rs1012669401 1788 dbSNP
rs151101241 1789 dbSNP
rs896776306 1795 dbSNP
rs1022802114 1796 dbSNP
rs1423004264 1797 dbSNP
rs1300234619 1798 dbSNP
rs1341219472 1799 dbSNP
rs1333599927 1800 dbSNP
rs531622205 1803 dbSNP
rs1012913066 1804 dbSNP
rs1268486025 1817 dbSNP
rs888243289 1831 dbSNP
rs770581087 1834 dbSNP
rs970096960 1834 dbSNP
rs1385709624 1837 dbSNP
rs1165073996 1839 dbSNP
rs1442413222 1843 dbSNP
rs1367335187 1853 dbSNP
rs1015902385 1857 dbSNP
rs1229367963 1858 dbSNP
rs1193305081 1859 dbSNP
rs550726343 1863 dbSNP
rs569272713 1864 dbSNP
rs999964834 1873 dbSNP
rs2970889 1874 dbSNP
rs1029609941 1878 dbSNP
rs955878908 1883 dbSNP
rs988637482 1888 dbSNP
rs146415729 1897 dbSNP
rs1283625944 1901 dbSNP
rs1228218279 1903 dbSNP
rs1328320129 1912 dbSNP
rs985468546 1914 dbSNP
rs1316131584 1915 dbSNP
rs191944704 1917 dbSNP
rs1365903744 1923 dbSNP
rs1304738760 1930 dbSNP
rs1488406645 1930 dbSNP
rs1422307904 1933 dbSNP
rs796183320 1934 dbSNP
rs377564961 1947 dbSNP
rs534098450 1952 dbSNP
rs1370899795 1956 dbSNP
rs1473765061 1960 dbSNP
rs559091964 1970 dbSNP
rs1477783311 1979 dbSNP
rs1269998805 1981 dbSNP
rs1182330929 1984 dbSNP
rs1412845045 1986 dbSNP
rs1289393193 1989 dbSNP
rs1442479165 1992 dbSNP
rs1160699044 1994 dbSNP
rs757593571 2001 dbSNP
rs978268373 2002 dbSNP
rs1978939 2009 dbSNP
rs538525414 2010 dbSNP
rs939577023 2014 dbSNP
rs930615906 2019 dbSNP
rs1056859230 2027 dbSNP
rs895446183 2041 dbSNP
rs1284052300 2047 dbSNP
rs907926248 2049 dbSNP
rs948459306 2050 dbSNP
rs1329102008 2051 dbSNP
rs940748795 2062 dbSNP
rs1381055272 2063 dbSNP
rs1044510413 2075 dbSNP
rs1056688342 2081 dbSNP
rs1242839649 2087 dbSNP
rs888304626 2088 dbSNP
rs1310446401 2112 dbSNP
rs1430582347 2128 dbSNP
rs1202277172 2135 dbSNP
rs374442467 2141 dbSNP
rs1005821172 2143 dbSNP
rs1045698844 2150 dbSNP
rs1015413551 2153 dbSNP
rs1281556131 2155 dbSNP
rs1198060693 2156 dbSNP
rs897111982 2162 dbSNP
rs1443605550 2164 dbSNP
rs555778771 2165 dbSNP
rs1366570998 2169 dbSNP
rs1279926374 2170 dbSNP
rs1029619853 2174 dbSNP
rs777061015 2176 dbSNP
rs543775188 2177 dbSNP
rs1374225623 2179 dbSNP
rs1442693066 2182 dbSNP
rs985573806 2183 dbSNP
rs1179196563 2186 dbSNP
rs1158371402 2189 dbSNP
rs1022827959 2190 dbSNP
rs561930668 2191 dbSNP
rs1439338325 2199 dbSNP
rs978700426 2202 dbSNP
rs1471387343 2210 dbSNP
rs924132541 2221 dbSNP
rs770010828 2222 dbSNP
rs541525223 2223 dbSNP
rs1236544088 2225 dbSNP
rs1178329554 2232 dbSNP
rs992378039 2246 dbSNP
rs1461813933 2260 dbSNP
rs916932246 2268 dbSNP
rs1427359814 2273 dbSNP
rs1311563980 2274 dbSNP
rs948345420 2275 dbSNP
rs553425561 2277 dbSNP
rs1284634033 2278 dbSNP
rs1225238561 2288 dbSNP
rs1351287889 2303 dbSNP
rs572223407 2305 dbSNP
rs545716788 2306 dbSNP
rs796889031 2308 dbSNP
rs1561730 2309 dbSNP
rs185589756 2310 dbSNP
rs1446415761 2312 dbSNP
rs952088919 2325 dbSNP
rs1319598320 2328 dbSNP
rs190443758 2329 dbSNP
rs1421896340 2331 dbSNP
rs1378914218 2332 dbSNP
rs370679886 2334 dbSNP
rs1037311443 2335 dbSNP
rs1158211012 2336 dbSNP
rs562880508 2339 dbSNP
rs766831901 2343 dbSNP
rs1376564326 2350 dbSNP
rs1237922174 2354 dbSNP
rs998064115 2361 dbSNP
rs1050938865 2363 dbSNP
rs889800410 2364 dbSNP
rs149015695 2366 dbSNP
rs1219367673 2372 dbSNP
rs1261929417 2373 dbSNP
rs1361195178 2374 dbSNP
rs751928337 2378 dbSNP
rs1056551755 2380 dbSNP
rs918108409 2381 dbSNP
rs1362118481 2385 dbSNP
rs1271270139 2391 dbSNP
rs1459962313 2392 dbSNP
rs1402409168 2396 dbSNP
rs1358948322 2399 dbSNP
rs1298003795 2400 dbSNP
rs115495247 2401 dbSNP
rs1351811946 2404 dbSNP
rs767149016 2406 dbSNP
rs999578112 2411 dbSNP
rs1423313515 2414 dbSNP
rs1031183984 2423 dbSNP
rs142969860 2436 dbSNP
rs527763360 2444 dbSNP
rs1188141722 2445 dbSNP
rs1476804803 2453 dbSNP
rs1436944315 2455 dbSNP
rs904135185 2457 dbSNP
rs74728268 2459 dbSNP
rs936921305 2471 dbSNP
rs1490794620 2472 dbSNP
rs916857176 2473 dbSNP
rs1220442673 2476 dbSNP
rs1307505711 2490 dbSNP
rs969615460 2491 dbSNP
rs980208270 2492 dbSNP
rs1274501942 2493 dbSNP
rs752351229 2499 dbSNP
rs879510599 2505 dbSNP
rs1405899615 2509 dbSNP
rs1370263123 2510 dbSNP
rs1036748620 2511 dbSNP
rs182088662 2514 dbSNP
rs1457606684 2515 dbSNP
rs1172109436 2520 dbSNP
rs373066448 2523 dbSNP
rs80145815 2529 dbSNP
rs933800531 2535 dbSNP
rs1463958814 2536 dbSNP
rs1467665768 2545 dbSNP
rs1171965684 2551 dbSNP
rs1050874341 2554 dbSNP
rs1434670234 2569 dbSNP
rs889736744 2579 dbSNP
rs1190204461 2583 dbSNP
rs1480771561 2585 dbSNP
rs1400039809 2586 dbSNP
rs1006807778 2588 dbSNP
rs1044121045 2596 dbSNP
rs901679167 2599 dbSNP
rs1316799324 2601 dbSNP
rs35749827 2612 dbSNP
rs1257974272 2615 dbSNP
rs151101538 2616 dbSNP
rs186240418 2618 dbSNP
rs367976105 2621 dbSNP
rs1386388942 2623 dbSNP
rs1374361648 2629 dbSNP
rs1333679258 2630 dbSNP
rs1444620550 2643 dbSNP
rs1399717211 2651 dbSNP
rs1332498918 2655 dbSNP
rs1467522854 2662 dbSNP
rs1375678964 2663 dbSNP
rs952096526 2665 dbSNP
rs1031068366 2670 dbSNP
rs189102903 2680 dbSNP
rs1013789962 2683 dbSNP
rs552617820 2693 dbSNP
rs1023800843 2712 dbSNP
rs553339631 2716 dbSNP
rs970082287 2725 dbSNP
rs1317944770 2737 dbSNP
rs948152538 2737 dbSNP
rs1311717566 2739 dbSNP
rs1341243305 2741 dbSNP
rs572076811 2742 dbSNP
rs1397659761 2743 dbSNP
rs144113565 2743 dbSNP
rs181358348 2744 dbSNP
rs753676674 2758 dbSNP
rs925454672 2764 dbSNP
rs570988857 2771 dbSNP
rs1017018033 2772 dbSNP
rs867045452 2774 dbSNP
rs1452460285 2798 dbSNP
rs1052608470 2800 dbSNP
rs1198909383 2810 dbSNP
rs1266904066 2815 dbSNP
rs962375854 2819 dbSNP
rs972472102 2820 dbSNP
rs1440249320 2821 dbSNP
rs918356916 2823 dbSNP
rs1200457566 2826 dbSNP
rs945677086 2829 dbSNP
rs757198594 2840 dbSNP
rs1214673459 2843 dbSNP
rs933737092 2863 dbSNP
rs1316053370 2867 dbSNP
rs1247042708 2870 dbSNP
rs1338845441 2872 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 150572.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714646. RNA binding protein: AGO2. Condition:mildMNase "PAR-CLIP data was present in GSM714647. RNA binding protein: AGO2. Condition:mildMNase ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ucuggggaggaGGUAGg 5'
                     ||||| 
Target 5' -----------CCAUCa 3'
 		1 - 6
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177599. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_1 PAR-CLIP data was present in ERX177611. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_3_1 PAR-CLIP data was present in ERX177627. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_4_5 PAR-CLIP data was present in ERX177632. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_4_10 PAR-CLIP data was present in ERX177603. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_5 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
Experimental Support 4 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions Prostate Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRX1760583. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP_A PAR-CLIP data was present in SRX1760591. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP_B PAR-CLIP data was present in SRX1760620. RNA binding protein: AGO2. Condition:AGO-CLIP-LAPC4_A PAR-CLIP data was present in SRX1760630. RNA binding protein: AGO2. Condition:AGO-CLIP-22RV1_A PAR-CLIP data was present in SRX1760631. RNA binding protein: AGO2. Condition:AGO-CLIP-22RV1_B PAR-CLIP data was present in SRX1760638. RNA binding protein: AGO2. Condition:AGO-CLIP-PC3-miR148 PAR-CLIP data was present in SRX1760639. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP-MDV_A PAR-CLIP data was present in SRX1760641. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP-MDV_B PAR-CLIP data was present in SRX1760628. RNA binding protein: AGO2. Condition:AGO-CLIP-LAPC4_B ...

- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.).

Article - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al.
- Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
CLIP-seq Support 1 for dataset GSM714646
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / mildMNase, repA
Location of target site ENST00000419482.2 | 3UTR | CAUCAGAUUGUGAGCUCCUGGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714647
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / mildMNase, repB
Location of target site ENST00000419482.2 | 3UTR | CCAUCAGAUUGUGAGCUCCUGGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000419482.2 | 3UTR | CAUCAGAUUGUGAGCUCCUGGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
141 hsa-miR-4534 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT087131 CRKL CRK like proto-oncogene, adaptor protein 2 2
MIRT179641 CAPZA1 capping actin protein of muscle Z-line alpha subunit 1 2 2
MIRT243304 SLC25A36 solute carrier family 25 member 36 2 2
MIRT325574 HIATL1 major facilitator superfamily domain containing 14B 2 4
MIRT448776 GNA13 G protein subunit alpha 13 2 2
MIRT451456 HSD11B1L hydroxysteroid 11-beta dehydrogenase 1 like 2 2
MIRT452150 PPP2R1B protein phosphatase 2 scaffold subunit Abeta 2 2
MIRT454199 HLA-A major histocompatibility complex, class I, A 2 2
MIRT455984 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT456058 SLC25A28 solute carrier family 25 member 28 2 2
MIRT457082 XPNPEP3 X-prolyl aminopeptidase 3 2 2
MIRT457278 ALDH9A1 aldehyde dehydrogenase 9 family member A1 2 2
MIRT457361 POFUT2 protein O-fucosyltransferase 2 2 2
MIRT457396 CAMK2A calcium/calmodulin dependent protein kinase II alpha 2 2
MIRT458817 ZNF843 zinc finger protein 843 2 2
MIRT459697 VPS37C VPS37C, ESCRT-I subunit 2 2
MIRT460346 ARL14EP ADP ribosylation factor like GTPase 14 effector protein 2 2
MIRT462713 MAPK13 mitogen-activated protein kinase 13 2 2
MIRT464278 VASH1 vasohibin 1 2 2
MIRT465634 TNRC18P2 trinucleotide repeat containing 18 pseudogene 2 2 10
MIRT465772 TMOD3 tropomodulin 3 2 2
MIRT466414 TFDP1 transcription factor Dp-1 2 2
MIRT467122 SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 2 8
MIRT467475 SMYD1 SET and MYND domain containing 1 2 4
MIRT468462 SET SET nuclear proto-oncogene 2 2
MIRT468618 SUMO1 small ubiquitin-like modifier 1 2 2
MIRT468835 RRM2 ribonucleotide reductase regulatory subunit M2 2 4
MIRT470890 PLXND1 plexin D1 2 2
MIRT473226 SMCR7L mitochondrial elongation factor 1 2 4
MIRT473858 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT474975 KCND3 potassium voltage-gated channel subfamily D member 3 2 2
MIRT475858 H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase 2 2
MIRT478569 CTNND1 catenin delta 1 2 2
MIRT479347 CEP97 centrosomal protein 97 2 2
MIRT479910 CCDC117 coiled-coil domain containing 117 2 4
MIRT480122 CALR calreticulin 2 2
MIRT480892 BCL9L B-cell CLL/lymphoma 9 like 2 2
MIRT481149 AVL9 AVL9 cell migration associated 2 6
MIRT481527 ARL5B ADP ribosylation factor like GTPase 5B 2 10
MIRT481896 ANKRD40 ankyrin repeat domain 40 2 2
MIRT490138 FN3K fructosamine 3 kinase 2 4
MIRT490329 ANK1 ankyrin 1 2 4
MIRT491472 TMEM214 transmembrane protein 214 2 2
MIRT503552 TIGIT T-cell immunoreceptor with Ig and ITIM domains 2 4
MIRT504413 TUBA1B tubulin alpha 1b 2 4
MIRT508207 SLC35E1 solute carrier family 35 member E1 2 2
MIRT508333 SLC37A4 solute carrier family 37 member 4 2 6
MIRT516381 TRAF3IP2 TRAF3 interacting protein 2 2 4
MIRT518549 ABCA6 ATP binding cassette subfamily A member 6 2 2
MIRT522545 MED28 mediator complex subunit 28 2 6
MIRT522592 MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1 like 2 2
MIRT522923 KAT6A lysine acetyltransferase 6A 2 4
MIRT525937 C11orf74 chromosome 11 open reading frame 74 2 2
MIRT527021 PABPN1L poly(A) binding protein nuclear 1 like, cytoplasmic 2 2
MIRT530396 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT530660 TRIM56 tripartite motif containing 56 2 2
MIRT531625 TM4SF5 transmembrane 4 L six family member 5 2 4
MIRT532703 TCN2 transcobalamin 2 2 4
MIRT540173 MB21D1 Mab-21 domain containing 1 2 2
MIRT540756 UTP6 UTP6, small subunit processome component 2 2
MIRT541966 ZNF485 zinc finger protein 485 2 2
MIRT542738 RAF1 Raf-1 proto-oncogene, serine/threonine kinase 2 2
MIRT543090 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT550687 YARS tyrosyl-tRNA synthetase 2 2
MIRT553466 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT559980 RELA RELA proto-oncogene, NF-kB subunit 2 2
MIRT561084 LLPH LLP homolog, long-term synaptic facilitation 2 2
MIRT561738 PLAGL2 PLAG1 like zinc finger 2 2 2
MIRT569872 KLK10 kallikrein related peptidase 10 2 2
MIRT570264 ARPC3 actin related protein 2/3 complex subunit 3 2 2
MIRT573431 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT573874 PRPS1L1 phosphoribosyl pyrophosphate synthetase 1-like 1 2 2
MIRT576905 Poteg POTE ankyrin domain family, member G 2 2
MIRT607934 ANG angiogenin 2 2
MIRT609472 RPL7L1 ribosomal protein L7 like 1 2 4
MIRT612179 EMC3 ER membrane protein complex subunit 3 2 2
MIRT613428 GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 2 2
MIRT613746 GPR155 G protein-coupled receptor 155 2 2
MIRT615034 DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 2
MIRT615565 JPH2 junctophilin 2 2 2
MIRT615937 MAP1LC3B microtubule associated protein 1 light chain 3 beta 2 2
MIRT616643 LRAT lecithin retinol acyltransferase 2 4
MIRT630890 SLC25A33 solute carrier family 25 member 33 2 2
MIRT636542 FAM126B family with sequence similarity 126 member B 2 2
MIRT641392 NUBPL nucleotide binding protein like 2 2
MIRT641410 SCN2B sodium voltage-gated channel beta subunit 2 2 2
MIRT643184 HYPK huntingtin interacting protein K 2 2
MIRT652600 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT653974 SEMA7A semaphorin 7A (John Milton Hagen blood group) 2 2
MIRT655692 NUDT3 nudix hydrolase 3 2 2
MIRT660734 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 4
MIRT661604 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT663284 ZNF675 zinc finger protein 675 2 2
MIRT666337 SKAP2 src kinase associated phosphoprotein 2 2 2
MIRT666636 RBMS2 RNA binding motif single stranded interacting protein 2 2 2
MIRT667125 OCIAD2 OCIA domain containing 2 2 2
MIRT670412 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT671119 ZNF573 zinc finger protein 573 2 2
MIRT671152 ANKRD9 ankyrin repeat domain 9 2 2
MIRT671336 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT671867 ZNF429 zinc finger protein 429 2 2
MIRT671972 IKZF3 IKAROS family zinc finger 3 2 2
MIRT672062 KIAA0930 KIAA0930 2 2
MIRT672652 SLC25A16 solute carrier family 25 member 16 2 4
MIRT672671 GTF2H5 general transcription factor IIH subunit 5 2 2
MIRT672768 UBE2V2 ubiquitin conjugating enzyme E2 V2 2 2
MIRT672927 LRRC2 leucine rich repeat containing 2 2 2
MIRT673156 C1orf50 chromosome 1 open reading frame 50 2 2
MIRT673270 RUNDC1 RUN domain containing 1 2 2
MIRT673329 THAP1 THAP domain containing 1 2 2
MIRT673348 SLC35F6 solute carrier family 35 member F6 2 2
MIRT673664 ZNF440 zinc finger protein 440 2 2
MIRT673901 DCTN6 dynactin subunit 6 2 2
MIRT674399 MYCBP MYC binding protein 2 2
MIRT674523 PRR23A proline rich 23A 2 2
MIRT674831 ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 2 2
MIRT675064 FGD6 FYVE, RhoGEF and PH domain containing 6 2 2
MIRT675078 CCR6 C-C motif chemokine receptor 6 2 2
MIRT675123 FSD2 fibronectin type III and SPRY domain containing 2 2 2
MIRT679399 IL10RB interleukin 10 receptor subunit beta 2 2
MIRT686608 TMEM70 transmembrane protein 70 2 2
MIRT690371 ZSWIM7 zinc finger SWIM-type containing 7 2 2
MIRT694464 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT695706 OLA1 Obg like ATPase 1 2 2
MIRT696846 WDR13 WD repeat domain 13 2 2
MIRT700894 PER2 period circadian clock 2 2 2
MIRT701924 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT704918 CCDC36 coiled-coil domain containing 36 2 2
MIRT706211 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT706546 GJD2 gap junction protein delta 2 2 2
MIRT706727 RFK riboflavin kinase 2 2
MIRT707366 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT707416 RRP7A ribosomal RNA processing 7 homolog A 2 2
MIRT710646 GLUL glutamate-ammonia ligase 2 2
MIRT712298 PGM2L1 phosphoglucomutase 2 like 1 2 2
MIRT713709 HIST3H2BB histone cluster 3 H2B family member b 2 2
MIRT713751 SLC9A8 solute carrier family 9 member A8 2 2
MIRT716423 VPS53 VPS53, GARP complex subunit 2 2
MIRT717169 UCHL3 ubiquitin C-terminal hydrolase L3 2 2
MIRT718877 PDIA3 protein disulfide isomerase family A member 3 2 2
MIRT720096 SPTLC3 serine palmitoyltransferase long chain base subunit 3 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4534 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4534 Fluorouracil 3385 NSC19893 approved sensitive High Pancreatic Cancer cell line (PATU8988)
hsa-miR-4534 Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4534 Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4534 Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4534 Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-mir-4534 Androstenedione+Anastrozole sensitive cell line (MCF-7)
hsa-mir-4534 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4534 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (cytosolic RNA)
hsa-miR-4534 Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-4534 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4534 Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4534 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4534 Platinum 23939 resistant tissue
hsa-miR-4534 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4534 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4534 Cisplatin 5460033 NSC119875 approved resistant cell line (A549)

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