miRTarBase - #MIRT468667


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pre-miRNA Information
pre-miRNA hsa-mir-497   
Genomic Coordinates chr17: 7017911 - 7018022
Synonyms MIRN497, hsa-mir-497, MIR497
Description Homo sapiens miR-497 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-497-3p
Sequence 64| CAAACCACACUGUGGUGUUAGA |85
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 3 17 - 7017957 29233923 MiREDiBase
A-to-I 4 17 - 7017956 29233923 MiREDiBase
A-to-I 20 17 - 7017940 24964909, 25521855, 27229138, 29165639, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1413601274 5 dbSNP
rs1028648384 6 dbSNP
rs1479092960 9 dbSNP
rs1261056598 10 dbSNP
rs997278260 11 dbSNP
rs1324708562 13 dbSNP
rs755634302 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SEC62   
Synonyms Dtrp1, HTP1, TLOC1, TP-1
Description SEC62 homolog, preprotein translocation factor
Transcript NM_003262   
Expression
Putative miRNA Targets on SEC62
3'UTR of SEC62
(miRNA target sites are highlighted)		 
>SEC62|NM_003262|3'UTR
   1 TCTGACTAATTTTGGGACTGAATGAATAAGTACAAGAGGTTGGATTTTCTATGTTGGCTGATTACCATATTGAACACATG
  81 GCATTTGTAGCATTCTTTAAATCTATCTACTGAAATGTATTTGACATTCAAGCAGTTATATTCGGTCCTTCATTTTATAG
 161 AATATTGGCACTATTATTGGTACAGTTTAAAGCCATTAATATGTTTTATCCATTTGATAATTTTACAGTAAGTAGGTCTC
 241 ATTCATTTTGACAGTTATCAAAGATGTACTTTCCACAGTTAAATTTACATTAATGGCAATTTTTGATAGTTTTATGGCTT
 321 TTTACTGTTAGACTAATCAAAAATAACTTTAAAAGGAACAAAGAAACTCCAACATTTCACATTATGCATAGTTATGTAGC
 401 CATTTCACAGTTTCTTTAAGATGTGTAAACTCATTGTCCTTGATAGTTTTTATTTTTCATTATAAAATTATACCAGGAGA
 481 TTTCTTTTAAGATTCTGAGTTAGCAGAGTTCAAAACTATTTTGTGGAAACAAGCCAACTAGTAACAATGCAGCAACACTT
 561 CTGGTTTAGCTAAATTATTTTTCCAATGTAGGAAATCCACACTGATTTGTACGTCTGACTGAGAGAAAGATGGTCGTCTC
 641 CAGCAGAGAAAGTGAACAGCATTTGTTGGAAGGTGATGGCTCTCCCTCCTCCCTCCCCATTTCATTGGCGTAACGTAAAG
 721 TGTATTCTGTACATAATTTACAAATAAAACATTTTATTTTAATTGTTACTTATTATTTAGATATTTCTCAACACTTAAAT
 801 TCATAAAATTAAGACCATGTAAGGGTATGTTTTTAGAGAAATGGAAGTTTGAGTAACCCACAGAACATCTGTGATCTTTC
 881 TACAGCAGCTTCAGTTTTGTGCCAACATTCCATGTATTTTGAATATGAGCAAAAACTGATCTTAAGAGCAGACTTAAAGT
 961 AGCTTTGTACGCCTTAATGTTCATTTTGATTTATTTTAAATCTTTACATTCAGAAATGAGATACTGTATTATCAGACCAG
1041 GAGGCATTGCTGTGAAAGATAATTTCCTATTCTAAAATATCAAATTTAAAATAAAGATAATGAAAGAAAACATAAGAGAA
1121 CTATTGGACTCTAATTGCTTTGAACTAGTTTTGCAGTTTGACTTTACGTCTTATACATCTTAGTTACAAGTCTTTGGAAA
1201 CTCTTGTTTACTTATGAGCATAATCATTCCTTGGAGTTATACTAACTAATAATGAATATTAAATGATTTTTCTTCAGTCA
1281 CAGTGAGAGCATCTTGCTTTGTGGTTGAAATAGGTAGTGTATGTCAGTCTTTGCTTTAGGCTGTTTCTCATCTAAGTGTT
1361 TGAATTAAAGATGTTAAATTTTTCTAATTGTGAAAAATATGTTTTCTGTATCGACACATTTTATTAAACTTGGCTTGATT
1441 GCTTCTTTATAGTAGTCCCTGTAAGTGGACATAAATGTGGCTATTTGATGTTAATGCAACTATGTCAAGGCTGCAATCAC
1521 TTTAATAGTTTCTTTTTAGCAAATAAATGTTCATTGATGAAGTGCCTGGGTATTTTCCCGTCCCATTTGCAGAGCTCTAC
1601 TACTTCATTTCCACAGTAAGCATATATATAATGATCACTTCTGAGTTTATCACCAGTAACATTGATACCTATTTTGGGGT
1681 ATAAACATGGTGTTTTTCAGAAATAAAAATTATTTCATTAACCTTTACTATTACTGTGATAATACCCAGGCACTCAATAT
1761 TCATCCTGAAATTTTTTATAATATATGTAATTTGTCTAGTCTTAAAGACATTTGGAGCATGGCCAACAGGAAGGTCAGCT
1841 TCTTACTGATGTGTGTGGATTCTTACAGAATGTTAGTACAAATTTTTATAAATATTTGGTGATCCCTGGGGGGAAATATC
1921 ATTCTTACTATGGTTAGAAAGTGAATTAGAAATTTCAGCTCAGTTTCTATTTTACTATTCAAGTTGTGTACTTTAAACAA
2001 ATATAAAAATCAAAAGGCTGCCTCTATTACAATCCTCAGTGGAATAGATGGCTATCTTTCTTGGCTAACATTAAATATTC
2081 TTGTACCAGAGCATGGAAAATCGTTTATAATTGTTAATAGAATGGCGATTTTTTTTTAAGAACTTCAGATTTGCTATGCT
2161 GCTGTAAGTAGAAAGCATGAAGCTTTTTGATCATGTAGGGCTTATTGTAGAGGGTATCAATTGGCCTAACTAAGCAGGAT
2241 TGAATTTACCAGAGGCTAAGTTCAGATAGTAAGAATAATGCATATGTGATTGTTCTTAAAGTCAATGTATTAAATAAGGT
2321 ATTTTTCCTTTTCCCTCTTACTGGATTTTTCAATTTTCAAACCATATGGCCTAGGTAACTTTAATTGAAATAATATAGAT
2401 TTAGTTGAATACTATTCAGGAAGTAATAAATTTTAATATATCACATTGAAATTATGCAGTGGTGATGAATTTTGGTGTTT
2481 CCCCCCTCTTTCTGGTTTTACATCATGAGGATCAGTTAGCTGCTGACAAGAAAAGTCATCTTGTGTCTTTTGTAAATTGA
2561 ATTTTTTTTTTAAATCTATTAGGAACTGGAAAACAGCAAGTATGGTTGATTCTCATTATTCAAGGTAGTTACGTTCTATA
2641 AAGTCACTGCGAACACTGAATTAGCAAATATAGAACCTAGGGGAAATACAAGGCTAGATTTCTGCAAGCCACTGGTCACA
2721 TTTTCATCAAGCAGTCAACATGTAAATTTCTGTTGTAAAGACACCTTATTTAATATAATCGATTCATTAACATTGAAGTC
2801 ATGACCAACAACACTGTAACTCATGCCTGAATGAAGCTTATCTGACACATAAGCTTCATAAGGCACACAACAGCCTTTTT
2881 ACCCTTAGGAACAGCTTTTTGCCCTTAGCACTATGCTTGGGGGCCATTTTAAACAGTGAAATCAAAAAAAGAACAGAAAT
2961 GCAAAAACCATGGCATTAGCGTAAAAAGGACACGTTTATAGTATGAAAGCTGGAACATGGCCTTGTTCAACCTCAGCTCA
3041 GAATATGTGTACAGCAAGTTTTTTGCTGTACCACAAAATTTTAGGTTAGGCAAATTCACAAATACGGAATCCATGAATAA
3121 CGAGGATCAACTGTACTTAACTATATTTTAAAGCTGTGACATTTATCTACCTGGTTTATGGAATAGAATTTATTGCTGAA
3201 TCATGCTCCAGTATTTGAGTGATGTTTTAAATATCCTATGTCTGAAAATAATTCCTCCTAATTGTGTGGTAATTTGCTTT
3281 TACTGTTTCCACAGTATTTCAGGTCTTTGCTCATTCACTCAGTAATACTGAGCACTTACCATGTACCAGAATTTTACTAG
3361 GCACAACCATGAATAAAAATACAATTCTCTTGCACCATTAAATAGTGTGTTAAGTGCTACGGCAGCAAATTGCTACATGT
3441 GCTGGATATCTCTTGTTTTCCCCTCCAGCTCCACTCTGCTCTTGCCCACAAAGCTGACCCGAATGGACCACAGCAGTGGG
3521 CTCCTATGCCTCCTGGCTTCTGAGTGGGTTTGGCCAAGGAGTGTCCTGGCCAGAGATCAGAGGATGGTAGGGTGCCTATT
3601 CTCGGCTCTTCTCCTGGGGTTGGGGGGCTGCCTTAGCAGCCAAAGGTCACTTCTCCCAAACTCCTTCCCTGCTTTCCAGG
3681 TTGCCAGTCCCTGCACTCTTCCTTTCTGGCCAAGGATGATGTCAGTTCTGCTGCTACTAGCCTGGAGTTGCAGAAGCTAC
3761 TGTGCTTCCTCTTTGGGTAGCCTATACCTATACTTATCTCCTCATAATATCTTCATGTAAAGAACCATCTGTTTCTTATT
3841 GGAATCAAGACCAATACCAAGGAGAAATTCCTAGGGAACAAAAATTCCAATGAGGAATTGACCTCTTTGTCAGATCCTTA
3921 TCACCAAACATTAGAAAAGATCTCATAACTTTATACAGCATGTTGTAAGCATTTTGATAACTAAAATCCTGTTCTAGTGA
4001 ATGTCATGCAGATAACTACACAAGGAGATTAATTTAAATTTGCCTTCTTTGGCAAGCCCTTAAACCAATGGCTAAAGCAG
4081 TTAGTTGTGAGTTTCTGAGTAGGTCCCAATGCGTTTATTTCATTTGTCCAACCTAGCACAGAGATCCTTTGATACTTTAA
4161 TTGCATGGCTTTTCCAATCAGACGAAATTTCAGTCTGAGAGAGGACATATTTTCTGAGGTTTATAGTTTTAGGATTGTCC
4241 AAAAGGCCTATGATCTCTTCTTAGCATGACAGAAAGAGGGAAAGATAAGTTAAATTTCAAGGGGGTCATATCATCACACT
4321 TTGGTCTTATTTCATTTTCAATGATTTCCTAGATCACTTTAACTTTTTTGTGTCATGGACTCCTCAGAATAATGGGTTTT
4401 TTTTGTTTGTTTGTTTGTTTGAGATGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCGAAATCTCAGCTCACTG
4481 CAACCTCCGCCTCCTGAGGTTCAAGTGATCCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACATGCCACCAC
4561 ACCCAGCTAATTTTTGTATTTTTTAGTAGAGACAGGGTTTCACCGTGTTGGCGAGACTGATCTTGAACTCCTGACATCAG
4641 GTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCATGCCTGGCCAGAATAATGTTTTTAA
4721 ATGCAGAAAAGGAAATGCATGGGGTTACAAGGGAAACGAATTACACTGAAGTGTAAGCTACCAAATAATTTATGATGTGG
4801 TAGTTATAGGTGTGCATTTAATAGCCAGATCTACGAGTGGATGTAATAACTGCTATGATGTTGAAGTAGCATAAAACATA
4881 TATTAGATATCTGCAACAACTGTGATGTAACATGAAAATACCTGATTTCTGTTGACAAAGTTACTGCTAGTACAACTGTG
4961 GATTGTTGTCTGCACTCGTCATTGAAGGAAATACTAAATTTTAGTTTTAGGCTAGTGAAATTAAAGTTAATTTTTCCCAT
5041 CCAAGTTCATGTATCTTCTGAATTCTATCCGTGAATCCCTTAGAGGTCTGTGAATTGTAGGTTAAGAACCCCTGCCCTAG
5121 CTAATCAGATCCACCAATGTTTCAAATAGGACTATAACTTATTCAAAGGCCAATGATACTTCGCATAATTCAATTTTAAT
5201 ATTATTCACATTTCATGTCACAAATTTAGTAAGTTACATGTGTTATGTGATGTTTTGTTTTGATAGATTATATCTTACTC
5281 CTAAATAAAAAGTCAAGATTTTTGTAGCAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agaUUGUGG--UGUCACACCAAac 5'
             |:||:|  :|  |||||||  
Target 5' gagAGCATCTTGCTTTGTGGTTga 3'
 1285 - 1308 137.00 -13.40
2 
miRNA  3' agAUUGUGGUGUC-------ACACCAAAc 5'
            ||||| ::|||       | |||||| 
Target 5' agTAACAATGCAGCAACACTTCTGGTTTa 3'
 540 - 568 132.00 -8.80
3 
miRNA  3' agAUUGUGGUGUCACACCAAAc 5'
            ||::|| ||  ||||| || 
Target 5' gcTAGTACAAC--TGTGGATTg 3'
 4946 - 4965 132.00 -15.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31538692 144 COSMIC
COSN31531229 254 COSMIC
COSN31488821 264 COSMIC
COSN28774859 443 COSMIC
COSN28690935 551 COSMIC
COSN14629499 636 COSMIC
COSN1271749 764 COSMIC
COSN24300319 903 COSMIC
COSN22488114 1016 COSMIC
COSN26818384 1021 COSMIC
COSN31609423 1119 COSMIC
COSN29540565 1219 COSMIC
COSN26795750 1237 COSMIC
COSN31530041 1383 COSMIC
COSN32064767 1450 COSMIC
COSN18945428 1510 COSMIC
COSN20976186 1567 COSMIC
COSN18720507 1582 COSMIC
COSN17449541 1708 COSMIC
COSN31962190 1846 COSMIC
COSN22769227 1920 COSMIC
COSN9532865 1964 COSMIC
COSN7834818 2221 COSMIC
COSN19525215 2402 COSMIC
COSN24482728 2573 COSMIC
COSN15723676 2783 COSMIC
COSN26851246 2945 COSMIC
COSN31572018 3191 COSMIC
COSN1930281 3311 COSMIC
COSN14461747 3436 COSMIC
COSN30544918 3507 COSMIC
COSN16430213 3595 COSMIC
COSN1930282 3636 COSMIC
COSN23883066 3801 COSMIC
COSN7052426 3959 COSMIC
COSN16263823 3971 COSMIC
COSN6753037 4234 COSMIC
COSN16332508 4376 COSMIC
COSN7626540 5066 COSMIC
COSN22855437 5242 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1316335896 1 dbSNP
rs770740975 4 dbSNP
rs965749573 11 dbSNP
rs574369052 14 dbSNP
rs1317933084 17 dbSNP
rs1299653806 22 dbSNP
rs1376898832 23 dbSNP
rs1395315823 25 dbSNP
rs1313567557 27 dbSNP
rs187667548 32 dbSNP
rs777550634 33 dbSNP
rs1257711635 34 dbSNP
rs1318867438 35 dbSNP
rs1200982058 39 dbSNP
rs1236031766 44 dbSNP
rs749288717 48 dbSNP
rs1182911607 50 dbSNP
rs372566491 52 dbSNP
rs111307351 56 dbSNP
rs1164061543 69 dbSNP
rs921683248 82 dbSNP
rs992635890 84 dbSNP
rs1239815976 90 dbSNP
rs1192070116 98 dbSNP
rs1447262316 101 dbSNP
rs946497883 106 dbSNP
rs1043961 115 dbSNP
rs778191128 140 dbSNP
rs1314727871 141 dbSNP
rs574096149 144 dbSNP
rs114020608 145 dbSNP
rs904213255 174 dbSNP
rs1342674206 175 dbSNP
rs34576140 180 dbSNP
rs560206075 185 dbSNP
rs553597062 187 dbSNP
rs1225731613 199 dbSNP
rs1364669737 203 dbSNP
rs1052890986 209 dbSNP
rs1406981907 212 dbSNP
rs1305089147 225 dbSNP
rs896426530 226 dbSNP
rs1477855246 231 dbSNP
rs576839515 231 dbSNP
rs1425411485 234 dbSNP
rs139198700 248 dbSNP
rs781343023 249 dbSNP
rs1803392 251 dbSNP
rs1009484203 259 dbSNP
rs1269995601 265 dbSNP
rs1484981627 270 dbSNP
rs1017750979 271 dbSNP
rs1272906712 274 dbSNP
rs1025795530 296 dbSNP
rs887286755 297 dbSNP
rs1320007248 309 dbSNP
rs1008862861 313 dbSNP
rs1281631887 327 dbSNP
rs1223083628 331 dbSNP
rs555250313 333 dbSNP
rs1344671948 347 dbSNP
rs1275264467 351 dbSNP
rs1438325652 353 dbSNP
rs773989175 357 dbSNP
rs1352754051 363 dbSNP
rs1019857624 367 dbSNP
rs1465695805 369 dbSNP
rs1173848234 370 dbSNP
rs1401779030 370 dbSNP
rs573331215 373 dbSNP
rs1425400613 374 dbSNP
rs1193342991 376 dbSNP
rs964686534 378 dbSNP
rs974361972 382 dbSNP
rs1406786734 393 dbSNP
rs1433351859 397 dbSNP
rs1175286934 398 dbSNP
rs746099358 402 dbSNP
rs756116830 409 dbSNP
rs1434050786 411 dbSNP
rs1203081515 412 dbSNP
rs1035516433 422 dbSNP
rs1303664941 435 dbSNP
rs1220805625 436 dbSNP
rs1370826905 437 dbSNP
rs960798620 443 dbSNP
rs1447369734 449 dbSNP
rs540839298 463 dbSNP
rs1308535366 467 dbSNP
rs1334173729 478 dbSNP
rs1355226555 485 dbSNP
rs1468821224 488 dbSNP
rs1359448581 492 dbSNP
rs565514133 494 dbSNP
rs1399334305 500 dbSNP
rs1407658275 516 dbSNP
rs923735129 526 dbSNP
rs1296728824 531 dbSNP
rs935170173 542 dbSNP
rs992439578 543 dbSNP
rs1372893461 563 dbSNP
rs1442129986 579 dbSNP
rs191894495 587 dbSNP
rs1183134436 596 dbSNP
rs34976827 603 dbSNP
rs544764246 613 dbSNP
rs1045060969 614 dbSNP
rs898519409 617 dbSNP
rs879541873 632 dbSNP
rs1314939679 636 dbSNP
rs1346112908 637 dbSNP
rs1240571730 639 dbSNP
rs1355834814 641 dbSNP
rs562861761 647 dbSNP
rs759009847 649 dbSNP
rs1274287664 657 dbSNP
rs1308817982 659 dbSNP
rs934324194 670 dbSNP
rs530109301 673 dbSNP
rs1231750520 676 dbSNP
rs1428170674 682 dbSNP
rs1468666932 687 dbSNP
rs887225877 690 dbSNP
rs1250958877 692 dbSNP
rs1453538071 698 dbSNP
rs1008393906 702 dbSNP
rs183913324 709 dbSNP
rs944445534 710 dbSNP
rs17217377 711 dbSNP
rs139996650 713 dbSNP
rs1485691001 715 dbSNP
rs997073032 716 dbSNP
rs1217152394 718 dbSNP
rs1289519886 720 dbSNP
rs1243907952 721 dbSNP
rs1168438674 722 dbSNP
rs1314301164 723 dbSNP
rs1212274334 727 dbSNP
rs1028575404 729 dbSNP
rs1353973809 730 dbSNP
rs1360910672 743 dbSNP
rs967694852 750 dbSNP
rs994956345 751 dbSNP
rs546365805 760 dbSNP
rs200603226 764 dbSNP
rs1369295974 770 dbSNP
rs886651607 782 dbSNP
rs1370678190 788 dbSNP
rs1004857426 794 dbSNP
rs1427987598 800 dbSNP
rs545863600 804 dbSNP
rs960973348 805 dbSNP
rs1266455666 812 dbSNP
rs956681792 816 dbSNP
rs1488795404 818 dbSNP
rs1267131953 826 dbSNP
rs1271705468 830 dbSNP
rs991991395 840 dbSNP
rs1215218025 842 dbSNP
rs1024131451 852 dbSNP
rs917758642 855 dbSNP
rs1270875831 856 dbSNP
rs186177062 858 dbSNP
rs1283096981 859 dbSNP
rs10325 869 dbSNP
rs969918097 872 dbSNP
rs115060594 883 dbSNP
rs980688088 885 dbSNP
rs1296886249 889 dbSNP
rs1193655010 900 dbSNP
rs1461557209 901 dbSNP
rs1401059266 903 dbSNP
rs1243568177 905 dbSNP
rs919893698 906 dbSNP
rs1185813179 907 dbSNP
rs1428835709 913 dbSNP
rs768609963 915 dbSNP
rs931295482 925 dbSNP
rs1418958971 927 dbSNP
rs1462002870 928 dbSNP
rs757789949 939 dbSNP
rs925867080 939 dbSNP
rs1047547087 940 dbSNP
rs1456949883 949 dbSNP
rs1392538309 950 dbSNP
rs1199954962 954 dbSNP
rs1258101487 954 dbSNP
rs550268129 962 dbSNP
rs568715500 968 dbSNP
rs1255042415 970 dbSNP
rs6772662 971 dbSNP
rs554933019 972 dbSNP
rs1305522248 977 dbSNP
rs1446645067 979 dbSNP
rs573469088 986 dbSNP
rs1347267402 988 dbSNP
rs944366144 990 dbSNP
rs1429297990 1002 dbSNP
rs1041193909 1014 dbSNP
rs1333504391 1022 dbSNP
rs1468288525 1027 dbSNP
rs1270091442 1029 dbSNP
rs1355612794 1034 dbSNP
rs1038823330 1059 dbSNP
rs534526489 1060 dbSNP
rs997019994 1071 dbSNP
rs1466377192 1083 dbSNP
rs1043281151 1089 dbSNP
rs1290838127 1093 dbSNP
rs867262806 1094 dbSNP
rs559192546 1112 dbSNP
rs774189670 1117 dbSNP
rs1333717256 1122 dbSNP
rs1205318235 1129 dbSNP
rs904821620 1131 dbSNP
rs1179618225 1132 dbSNP
rs577554996 1161 dbSNP
rs1238696954 1163 dbSNP
rs1180038495 1166 dbSNP
rs1031111113 1168 dbSNP
rs1215035771 1169 dbSNP
rs930822927 1171 dbSNP
rs1258136169 1172 dbSNP
rs1049192099 1173 dbSNP
rs748370015 1174 dbSNP
rs544677328 1176 dbSNP
rs1312091896 1177 dbSNP
rs1005116150 1179 dbSNP
rs1013772938 1183 dbSNP
rs770352966 1187 dbSNP
rs1024776634 1189 dbSNP
rs1190169222 1204 dbSNP
rs563021120 1207 dbSNP
rs1397968098 1212 dbSNP
rs969219661 1216 dbSNP
rs1803393 1219 dbSNP
rs980635781 1220 dbSNP
rs919839733 1221 dbSNP
rs1418859097 1225 dbSNP
rs1380843900 1232 dbSNP
rs1160321557 1236 dbSNP
rs1442262804 1240 dbSNP
rs896519750 1247 dbSNP
rs773599325 1254 dbSNP
rs952631301 1258 dbSNP
rs1012658662 1260 dbSNP
rs574707722 1262 dbSNP
rs1216432151 1266 dbSNP
rs1488784064 1267 dbSNP
rs200257333 1282 dbSNP
rs1244360473 1285 dbSNP
rs968088860 1287 dbSNP
rs190451047 1292 dbSNP
rs766927414 1308 dbSNP
rs955837377 1313 dbSNP
rs368370527 1316 dbSNP
rs988780915 1317 dbSNP
rs908555730 1320 dbSNP
rs1399174636 1337 dbSNP
rs1019278517 1338 dbSNP
rs1299996965 1342 dbSNP
rs1403572377 1343 dbSNP
rs1318309089 1348 dbSNP
rs1412947801 1350 dbSNP
rs944096581 1376 dbSNP
rs182706286 1378 dbSNP
rs147246123 1379 dbSNP
rs1370989227 1391 dbSNP
rs1192409568 1401 dbSNP
rs1417096437 1402 dbSNP
rs1265751036 1407 dbSNP
rs1220682158 1408 dbSNP
rs921381855 1409 dbSNP
rs1291208147 1410 dbSNP
rs1211717845 1411 dbSNP
rs1310583181 1413 dbSNP
rs1277825804 1414 dbSNP
rs1219435438 1416 dbSNP
rs1342577770 1427 dbSNP
rs974781625 1441 dbSNP
rs546527426 1450 dbSNP
rs564694841 1454 dbSNP
rs532181068 1459 dbSNP
rs1239385884 1469 dbSNP
rs772933542 1472 dbSNP
rs1406616004 1476 dbSNP
rs904769296 1482 dbSNP
rs1169561914 1489 dbSNP
rs550235643 1494 dbSNP
rs1465855315 1495 dbSNP
rs999523758 1503 dbSNP
rs1348362605 1517 dbSNP
rs1425302839 1518 dbSNP
rs930373040 1521 dbSNP
rs115225428 1524 dbSNP
rs908079819 1526 dbSNP
rs1201580750 1529 dbSNP
rs892130596 1530 dbSNP
rs535999988 1541 dbSNP
rs548148296 1543 dbSNP
rs1486628556 1548 dbSNP
rs1013304079 1552 dbSNP
rs1199325873 1559 dbSNP
rs187119778 1561 dbSNP
rs1255554254 1569 dbSNP
rs1261493532 1571 dbSNP
rs16854700 1580 dbSNP
rs1045441999 1581 dbSNP
rs903955182 1589 dbSNP
rs774677181 1590 dbSNP
rs1365741232 1595 dbSNP
rs1438477019 1604 dbSNP
rs1002021261 1616 dbSNP
rs1158420255 1619 dbSNP
rs1026849343 1623 dbSNP
rs1396030766 1625 dbSNP
rs1000971914 1632 dbSNP
rs1402024178 1644 dbSNP
rs1173441614 1651 dbSNP
rs952630758 1652 dbSNP
rs1031076389 1661 dbSNP
rs983107560 1662 dbSNP
rs1426259439 1663 dbSNP
rs1174643529 1672 dbSNP
rs1193266522 1677 dbSNP
rs1437152783 1678 dbSNP
rs1172293369 1679 dbSNP
rs760401121 1694 dbSNP
rs1400923074 1700 dbSNP
rs1209624291 1704 dbSNP
rs78450791 1708 dbSNP
rs965750200 1734 dbSNP
rs976817995 1735 dbSNP
rs921328790 1737 dbSNP
rs1330543737 1740 dbSNP
rs1351500550 1743 dbSNP
rs932766473 1750 dbSNP
rs978868387 1752 dbSNP
rs1446897349 1756 dbSNP
rs1378408587 1758 dbSNP
rs577485161 1763 dbSNP
rs974454543 1772 dbSNP
rs926139727 1773 dbSNP
rs934891577 1783 dbSNP
rs1349756288 1784 dbSNP
rs1028640643 1792 dbSNP
rs951702312 1804 dbSNP
rs1053790490 1811 dbSNP
rs1159721025 1812 dbSNP
rs763536114 1813 dbSNP
rs548550911 1819 dbSNP
rs896105210 1829 dbSNP
rs1411673137 1838 dbSNP
rs1181325211 1839 dbSNP
rs907628168 1853 dbSNP
rs1483730884 1867 dbSNP
rs1279516546 1877 dbSNP
rs776185373 1878 dbSNP
rs1487150818 1883 dbSNP
rs1344471530 1894 dbSNP
rs918187187 1908 dbSNP
rs940871757 1908 dbSNP
rs992700434 1908 dbSNP
rs1227230936 1909 dbSNP
rs1196466985 1913 dbSNP
rs949071816 1914 dbSNP
rs747863843 1918 dbSNP
rs1045321115 1920 dbSNP
rs1436319225 1921 dbSNP
rs1299378212 1929 dbSNP
rs538456854 1931 dbSNP
rs903881571 1942 dbSNP
rs1348627712 1946 dbSNP
rs543076031 1949 dbSNP
rs1424475143 1955 dbSNP
rs1046121699 1960 dbSNP
rs1254076879 1962 dbSNP
rs759007054 1971 dbSNP
rs1476735045 1978 dbSNP
rs1262248899 1981 dbSNP
rs1486839681 1988 dbSNP
rs1001967563 2005 dbSNP
rs556512885 2006 dbSNP
rs1321737033 2011 dbSNP
rs1294771221 2024 dbSNP
rs1216372029 2029 dbSNP
rs1339411644 2031 dbSNP
rs1377547813 2033 dbSNP
rs1402230620 2034 dbSNP
rs1366202092 2035 dbSNP
rs1293390809 2045 dbSNP
rs1462893973 2046 dbSNP
rs1010085463 2047 dbSNP
rs1351646109 2050 dbSNP
rs565327001 2054 dbSNP
rs116254941 2055 dbSNP
rs1465343068 2065 dbSNP
rs1424588198 2071 dbSNP
rs1194200840 2073 dbSNP
rs566237577 2081 dbSNP
rs1265198791 2090 dbSNP
rs996525415 2096 dbSNP
rs888285685 2099 dbSNP
rs1274550285 2103 dbSNP
rs879390218 2104 dbSNP
rs1015922289 2105 dbSNP
rs752029316 2109 dbSNP
rs976706380 2111 dbSNP
rs1258302888 2118 dbSNP
rs1230081465 2123 dbSNP
rs1310755251 2124 dbSNP
rs542003682 2126 dbSNP
rs1005801950 2129 dbSNP
rs951754000 2129 dbSNP
rs1014634848 2130 dbSNP
rs962068251 2133 dbSNP
rs1028290816 2138 dbSNP
rs1345099464 2140 dbSNP
rs1302340943 2144 dbSNP
rs1173021688 2149 dbSNP
rs1326954178 2149 dbSNP
rs1463353670 2151 dbSNP
rs1375681673 2154 dbSNP
rs1229463099 2155 dbSNP
rs1253173932 2161 dbSNP
rs192804238 2162 dbSNP
rs1452338018 2180 dbSNP
rs116329243 2185 dbSNP
rs926111446 2190 dbSNP
rs969567805 2194 dbSNP
rs934818580 2195 dbSNP
rs1274039732 2196 dbSNP
rs1197135120 2202 dbSNP
rs981051730 2206 dbSNP
rs989034842 2208 dbSNP
rs1342393295 2209 dbSNP
rs917472211 2214 dbSNP
rs1286542350 2217 dbSNP
rs950359890 2221 dbSNP
rs540087208 2222 dbSNP
rs1052408286 2226 dbSNP
rs750849847 2233 dbSNP
rs1331165840 2241 dbSNP
rs1394550136 2251 dbSNP
rs904879213 2255 dbSNP
rs1195925453 2264 dbSNP
rs564860114 2268 dbSNP
rs1302108907 2278 dbSNP
rs1466358805 2290 dbSNP
rs532144038 2297 dbSNP
rs937710061 2306 dbSNP
rs1048165048 2314 dbSNP
rs944144686 2320 dbSNP
rs888240858 2329 dbSNP
rs1041123692 2337 dbSNP
rs756899167 2340 dbSNP
rs1440392127 2343 dbSNP
rs901708820 2346 dbSNP
rs1201394327 2351 dbSNP
rs1004434221 2354 dbSNP
rs1284532594 2361 dbSNP
rs1216473772 2364 dbSNP
rs995964347 2367 dbSNP
rs1396234408 2371 dbSNP
rs543989267 2372 dbSNP
rs901055882 2386 dbSNP
rs1385336682 2403 dbSNP
rs1005854653 2415 dbSNP
rs998073933 2420 dbSNP
rs562571719 2421 dbSNP
rs1419071072 2422 dbSNP
rs1385559656 2439 dbSNP
rs1159859254 2441 dbSNP
rs529794614 2444 dbSNP
rs1028238472 2456 dbSNP
rs1367541739 2459 dbSNP
rs1187751859 2470 dbSNP
rs1476409395 2472 dbSNP
rs1261531768 2481 dbSNP
rs1216316871 2487 dbSNP
rs1488937858 2494 dbSNP
rs1286954114 2501 dbSNP
rs1014518505 2511 dbSNP
rs1338613136 2517 dbSNP
rs1355662420 2518 dbSNP
rs548021079 2521 dbSNP
rs961716468 2525 dbSNP
rs1013779523 2528 dbSNP
rs954055417 2528 dbSNP
rs566422729 2538 dbSNP
rs531055860 2541 dbSNP
rs1293926273 2557 dbSNP
rs1326955951 2562 dbSNP
rs202239200 2562 dbSNP
rs536560265 2562 dbSNP
rs969966288 2571 dbSNP
rs527287346 2572 dbSNP
rs756313227 2579 dbSNP
rs1164971666 2599 dbSNP
rs182471241 2603 dbSNP
rs958253656 2605 dbSNP
rs189182684 2615 dbSNP
rs1478316337 2616 dbSNP
rs956174268 2617 dbSNP
rs989372026 2625 dbSNP
rs944045622 2628 dbSNP
rs1188048880 2631 dbSNP
rs552760987 2632 dbSNP
rs917438029 2632 dbSNP
rs1132237 2633 dbSNP
rs562823204 2634 dbSNP
rs780048015 2636 dbSNP
rs1434267830 2649 dbSNP
rs927563492 2651 dbSNP
rs1050187136 2652 dbSNP
rs568599509 2656 dbSNP
rs1442379415 2671 dbSNP
rs1287106290 2672 dbSNP
rs937657967 2677 dbSNP
rs1410923184 2679 dbSNP
rs1359839795 2680 dbSNP
rs1422051586 2686 dbSNP
rs887713334 2690 dbSNP
rs1477998227 2694 dbSNP
rs1254105641 2698 dbSNP
rs1195652612 2706 dbSNP
rs1048113454 2710 dbSNP
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rs1313594151 2750 dbSNP
rs746887968 2761 dbSNP
rs909608930 2765 dbSNP
rs1226860788 2774 dbSNP
rs1439736289 2781 dbSNP
rs755038459 2782 dbSNP
rs1013247576 2798 dbSNP
rs1037247694 2802 dbSNP
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rs772203003 2995 dbSNP
rs1302279152 3000 dbSNP
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rs544227835 3016 dbSNP
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rs1006832985 3477 dbSNP
rs1015176345 3478 dbSNP
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rs191925965 3500 dbSNP
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rs998195320 3670 dbSNP
rs1422965554 3671 dbSNP
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rs535605382 3680 dbSNP
rs76839001 3685 dbSNP
rs1006545913 3687 dbSNP
rs556188639 3690 dbSNP
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rs1005528783 3859 dbSNP
rs1036511441 3863 dbSNP
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rs1262630122 3891 dbSNP
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rs889406470 3899 dbSNP
rs1253732562 3901 dbSNP
rs1006497245 3907 dbSNP
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rs529628703 3927 dbSNP
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rs1485306193 3943 dbSNP
rs547565924 3950 dbSNP
rs16854708 3951 dbSNP
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rs115975578 3964 dbSNP
rs545171149 3984 dbSNP
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rs764973607 3997 dbSNP
rs981907964 4001 dbSNP
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rs1162606503 4068 dbSNP
rs1474747876 4070 dbSNP
rs958642119 4075 dbSNP
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rs1484826570 4094 dbSNP
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rs777899137 4112 dbSNP
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rs1289527662 4177 dbSNP
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rs1349892316 4210 dbSNP
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rs545058671 4402 dbSNP
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rs565142490 4402 dbSNP
rs989431117 4402 dbSNP
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rs368015105 4405 dbSNP
rs958589823 4406 dbSNP
rs1373137613 4410 dbSNP
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rs1344355727 4444 dbSNP
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rs1438177966 4642 dbSNP
rs138584938 4658 dbSNP
rs1012786346 4661 dbSNP
rs760972658 4669 dbSNP
rs1322107022 4670 dbSNP
rs1459512207 4671 dbSNP
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rs1385045048 4683 dbSNP
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rs148836868 4685 dbSNP
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rs1322802079 4692 dbSNP
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rs1316332366 4752 dbSNP
rs1218200630 4753 dbSNP
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rs1268326452 4759 dbSNP
rs1226115387 4768 dbSNP
rs1365339631 4778 dbSNP
rs972443875 4783 dbSNP
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rs954752643 4790 dbSNP
rs1393195917 4792 dbSNP
rs1034426413 4797 dbSNP
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rs1167812634 4801 dbSNP
rs1430909335 4807 dbSNP
rs1392121907 4812 dbSNP
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rs752795747 4860 dbSNP
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rs758579559 4876 dbSNP
rs74574468 4877 dbSNP
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rs955036136 4897 dbSNP
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rs1208164158 4997 dbSNP
rs1045966929 5021 dbSNP
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rs751616736 5024 dbSNP
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rs207464057 5040 dbSNP
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rs894269296 5045 dbSNP
rs1372379425 5046 dbSNP
rs1265185154 5059 dbSNP
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rs539657657 5071 dbSNP
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rs1399182366 5073 dbSNP
rs1407528024 5075 dbSNP
rs899052892 5081 dbSNP
rs1260461532 5087 dbSNP
rs780844058 5089 dbSNP
rs370780923 5096 dbSNP
rs1414141628 5100 dbSNP
rs186300965 5102 dbSNP
rs954702155 5113 dbSNP
rs190791212 5114 dbSNP
rs1017623443 5118 dbSNP
rs1237562800 5137 dbSNP
rs769307564 5138 dbSNP
rs1029580017 5150 dbSNP
rs573592682 5161 dbSNP
rs1364114112 5163 dbSNP
rs115999290 5165 dbSNP
rs1291768030 5171 dbSNP
rs779720116 5174 dbSNP
rs962414879 5179 dbSNP
rs978349407 5183 dbSNP
rs928236082 5184 dbSNP
rs748749028 5185 dbSNP
rs114388571 5186 dbSNP
rs138394050 5200 dbSNP
rs1321426213 5212 dbSNP
rs1394460722 5217 dbSNP
rs781600108 5226 dbSNP
rs1162453058 5227 dbSNP
rs1423179082 5234 dbSNP
rs1414441105 5237 dbSNP
rs533316679 5244 dbSNP
rs915652017 5245 dbSNP
rs1312521664 5247 dbSNP
rs1378069105 5251 dbSNP
rs937330710 5262 dbSNP
rs1246835988 5273 dbSNP
rs948514588 5275 dbSNP
rs1037899564 5279 dbSNP
rs756639509 5282 dbSNP
rs1055772687 5286 dbSNP
rs899005679 5290 dbSNP
rs181584466 5294 dbSNP
rs1221294403 5304 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000337002.4 | 3UTR | UUUUAAAGCUGUGACAUUUAUCUACCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer 0.64 3.8e-4 0.718 3.9e-5 24 Click to see details
GSE42095 Differentiated embryonic stem cells 0.621 7.8e-4 0.284 9.5e-2 23 Click to see details
GSE28260 Renal cortex and medulla 0.616 1.2e-2 0.740 1.9e-3 13 Click to see details
GSE38226 Liver fibrosis 0.464 1.7e-2 0.499 1.1e-2 21 Click to see details
GSE26953 Aortic valvular endothelial cells 0.424 1.9e-2 0.359 4.2e-2 24 Click to see details
GSE17498 Multiple myeloma 0.308 2.7e-2 0.181 1.3e-1 40 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.14 2.5e-1 -0.274 9.3e-2 25 Click to see details
GSE19350 CNS germ cell tumors -0.143 3.3e-1 0.301 1.7e-1 12 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.099 3.4e-1 -0.510 1.1e-2 20 Click to see details
GSE32688 Pancreatic cancer 0.053 3.9e-1 -0.005 4.9e-1 32 Click to see details
GSE21687 Ependynoma primary tumors 0.004 4.9e-1 0.021 4.3e-1 64 Click to see details
GSE21687 Ependynoma primary tumors 0.004 4.9e-1 0.021 4.3e-1 64 Click to see details
GSE21687 Ependynoma primary tumors 0.004 4.9e-1 0.021 4.3e-1 64 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
THCA 0.276 0.03 0.273 0.03 45 Click to see details
HNSC -0.371 0.06 -0.397 0.05 18 Click to see details
STAD 0.267 0.12 0.249 0.14 21 Click to see details
KICH -0.313 0.13 -0.254 0.18 15 Click to see details
CHOL -0.514 0.15 -0.371 0.23 6 Click to see details
KIRP -0.224 0.16 -0.365 0.05 21 Click to see details
BLCA -0.664 0.17 -0.800 0.1 4 Click to see details
BRCA -0.104 0.26 -0.047 0.38 42 Click to see details
KIRC 0.1 0.26 0.134 0.2 43 Click to see details
LUSC -0.107 0.29 0.014 0.47 30 Click to see details
PRAD 0.083 0.29 0.139 0.18 46 Click to see details
PAAD 0.382 0.31 0.400 0.3 4 Click to see details
LUAD 0.266 0.37 -0.200 0.4 4 Click to see details
LIHC 0.056 0.38 0.111 0.28 30 Click to see details
ESCA -0.075 0.42 -0.042 0.45 10 Click to see details
UCEC 0.031 0.45 0.024 0.46 16 Click to see details
UCEC 0.031 0.45 0.024 0.46 16 Click to see details
UCEC 0.031 0.45 0.024 0.46 16 Click to see details
UCEC 0.031 0.45 0.024 0.46 16 Click to see details
95 hsa-miR-497-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT092955 CYP2U1 cytochrome P450 family 2 subfamily U member 1 2 4
MIRT124568 PRRC2B proline rich coiled-coil 2B 2 2
MIRT125196 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 4
MIRT147296 KPNA2 karyopherin subunit alpha 2 2 8
MIRT163999 KIAA1109 KIAA1109 2 4
MIRT252495 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT357969 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT443007 TRIOBP TRIO and F-actin binding protein 2 2
MIRT443524 NETO1 neuropilin and tolloid like 1 2 2
MIRT443573 EVX2 even-skipped homeobox 2 2 2
MIRT443656 BACH1 BTB domain and CNC homolog 1 2 2
MIRT460670 KRT10 keratin 10 2 8
MIRT464761 UBE2N ubiquitin conjugating enzyme E2 N 2 2
MIRT465032 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT465040 TTC39C tetratricopeptide repeat domain 39C 2 2
MIRT468667 SEC62 SEC62 homolog, preprotein translocation factor 2 2
MIRT473694 MAPK8 mitogen-activated protein kinase 8 2 4
MIRT477618 EFNA3 ephrin A3 2 2
MIRT480506 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT480592 BUB3 BUB3, mitotic checkpoint protein 2 2
MIRT486915 ZNF398 zinc finger protein 398 2 6
MIRT487770 ANKEF1 ankyrin repeat and EF-hand domain containing 1 2 16
MIRT493265 MDFIC MyoD family inhibitor domain containing 2 2
MIRT495271 SLC1A2 solute carrier family 1 member 2 2 4
MIRT495309 CHST12 carbohydrate sulfotransferase 12 2 2
MIRT496681 DPP6 dipeptidyl peptidase like 6 2 4
MIRT496891 FOXP1 forkhead box P1 2 2
MIRT497330 IRF4 interferon regulatory factor 4 2 2
MIRT498272 KIAA1644 KIAA1644 2 2
MIRT498634 CHD4 chromodomain helicase DNA binding protein 4 2 10
MIRT500581 USP53 ubiquitin specific peptidase 53 2 2
MIRT500751 TMPPE transmembrane protein with metallophosphoesterase domain 2 6
MIRT509668 ZNF354B zinc finger protein 354B 2 10
MIRT510919 PSMA2 proteasome subunit alpha 2 2 4
MIRT519118 CEP76 centrosomal protein 76 2 2
MIRT526193 ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) 2 2
MIRT526746 HLA-DOB major histocompatibility complex, class II, DO beta 2 2
MIRT527270 FBLN2 fibulin 2 2 2
MIRT528198 PLEKHM2 pleckstrin homology and RUN domain containing M2 2 2
MIRT528330 TBC1D22B TBC1 domain family member 22B 2 2
MIRT530346 GABRB3 gamma-aminobutyric acid type A receptor beta3 subunit 2 2
MIRT533627 TMX3 thioredoxin related transmembrane protein 3 2 2
MIRT533738 TMEM200C transmembrane protein 200C 2 2
MIRT533779 TMEM133 transmembrane protein 133 2 2
MIRT534317 SKIDA1 SKI/DACH domain containing 1 2 2
MIRT538438 COG5 component of oligomeric golgi complex 5 2 2
MIRT539156 AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2 2
MIRT539474 ADARB2 adenosine deaminase, RNA specific B2 (inactive) 2 2
MIRT539620 SHISA9 shisa family member 9 2 2
MIRT539650 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 2
MIRT540346 OPHN1 oligophrenin 1 2 2
MIRT540412 PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 2 2
MIRT541200 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 2
MIRT541395 CDC27 cell division cycle 27 2 2
MIRT546443 SNX5 sorting nexin 5 2 2
MIRT547369 MSI2 musashi RNA binding protein 2 2 2
MIRT553288 TSPAN3 tetraspanin 3 2 2
MIRT554402 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT557822 FOXN2 forkhead box N2 2 2
MIRT568530 ANP32E acidic nuclear phosphoprotein 32 family member E 2 2
MIRT569508 THYN1 thymocyte nuclear protein 1 2 2
MIRT570707 FAM69A family with sequence similarity 69 member A 2 2
MIRT608376 PIWIL2 piwi like RNA-mediated gene silencing 2 2 2
MIRT608483 NKTR natural killer cell triggering receptor 2 6
MIRT613533 TRA2B transformer 2 beta homolog 2 2
MIRT616601 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT618166 DUSP18 dual specificity phosphatase 18 2 2
MIRT632059 CEP135 centrosomal protein 135 2 2
MIRT647379 ZDHHC23 zinc finger DHHC-type containing 23 2 2
MIRT648366 POTED POTE ankyrin domain family member D 2 2
MIRT651075 ZNF518B zinc finger protein 518B 2 4
MIRT653618 SLC30A4 solute carrier family 30 member 4 2 2
MIRT653636 SLC30A1 solute carrier family 30 member 1 2 2
MIRT654895 POU2F1 POU class 2 homeobox 1 2 2
MIRT656232 MFSD6 major facilitator superfamily domain containing 6 2 2
MIRT659880 CAPRIN1 cell cycle associated protein 1 2 2
MIRT660526 ARL4C ADP ribosylation factor like GTPase 4C 2 2
MIRT666286 SLC30A3 solute carrier family 30 member 3 2 2
MIRT686808 SNX2 sorting nexin 2 2 4
MIRT695302 TK1 thymidine kinase 1 2 2
MIRT699737 SERINC3 serine incorporator 3 2 2
MIRT700794 PIAS2 protein inhibitor of activated STAT 2 2 2
MIRT712270 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT712617 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT714264 RPL10A ribosomal protein L10a 2 2
MIRT715072 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT715386 TADA3 transcriptional adaptor 3 2 2
MIRT716397 NPAS1 neuronal PAS domain protein 1 2 2
MIRT725328 NFASC neurofascin 2 2
MIRT725503 GANAB glucosidase II alpha subunit 2 2
MIRT732913 IRAK2 interleukin 1 receptor associated kinase 2 3 0
MIRT734890 SMAD3 SMAD family member 3 3 0
MIRT737328 LINC02476 long intergenic non-protein coding RNA 2476 3 0
MIRT737544 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 4 0
MIRT755545 PAK1 p21 (RAC1) activated kinase 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-497 Bufalin NULL 9547215 Quantitative real-time PCR colorectal cancer HCT116 cells 24375248 2014 up-regulated
miR-497 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miR-497 Ethanol NULL 702 Quantitative real-time PCR CIE10 22141737 2012 up-regulated
miR-497 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
miR-497 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-497 Tamoxifen 2733525 NSC180973 approved sensitive Low Breast Cancer cell line (MCF-7, T47D)
hsa-mir-497 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-497 Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-497 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-497 Tamoxifen 2733525 NSC180973 approved sensitive cell line (MCF7)
hsa-mir-497 Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-miR-497-3p Mitoxantrone 4212 NSC279836 approved sensitive High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-497-3p Docetaxel 148124 NSC628503 approved resistant High Breast Cancer cell line (MDA-MB-231, MCF-7)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant High Non-Small Cell Lung Cancer cell line (A549, PC-9)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant Low Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-497-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-497-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant tissue
hsa-miR-497-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-497-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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