miRTarBase - #MIRT469225


—
pre-miRNA Information
pre-miRNA hsa-mir-3529   
Genomic Coordinates chr15: 88611847 - 88611924
Description Homo sapiens miR-3529 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3529-5p
Sequence 10| AGGUAGACUGGGAUUUGUUGUU |31
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs747160976 1 dbSNP
rs777738449 2 dbSNP
rs1421978871 4 dbSNP
rs1167726772 6 dbSNP
rs1355306872 6 dbSNP
rs1286285953 7 dbSNP
rs1233166293 8 dbSNP
rs772151253 9 dbSNP
rs1204890571 13 dbSNP
rs1250455629 18 dbSNP
rs748388180 19 dbSNP
rs1303070972 21 dbSNP
Putative Targets

Gene Information
Gene Symbol RHOBTB3   
Synonyms -
Description Rho related BTB domain containing 3
Transcript NM_014899   
Expression
Putative miRNA Targets on RHOBTB3
3'UTR of RHOBTB3
(miRNA target sites are highlighted)		 
>RHOBTB3|NM_014899|3'UTR
   1 CCTGGAGCTTTTATACACTACATTTCTTTTTTATTATTATGAAGAATGGGATACCTCCAGGTTCCAGTAAAATTCTTCTG
  81 ACCGAAACCAATGTGGGTGTTAGAAAAATTACCATATAGCTTAATATGTTTATTAGTTCTCTTTGGAAAAAAACTACCAC
 161 TGTGGTCTTAAAAGGGAACAAAATATACCATAGGCTAAAACTAAGGCTTTCACTCTAGAATGCAAAGCTGTTTTGCAGCT
 241 GTTTTCCCTTAAAGATGTCCTGTTGCTTTAGTGATATTTAGACCCCTCTCAGTTAAGAAATGCTTAGATTAAAAAAAAAA
 321 AATTACGTAGGATTAATACAGAAATTTAATCATGTCTGATTAATTGCTCTATTAAAATAAGGGGCATTTAAAGACCCAGC
 401 ATAACCATTTGTATAATGAGAAATCTAGGGGAAAACCAATCAGTCCAACATGAGATTTTAGGAATAGAAATTTGCCGGCC
 481 ATTTGGAAAGTGAAATGCCACTTAGTTCTCAATTGATGACAGTGTTTGAATCATCATAAAAAAAATACCTGCTTTTCATC
 561 TGGACAACCCAATTGAGCCACTTTATCTCCTTTTGGCAATCTGAGTAGGCGGGGAACCTAGGCAGGGCTGGCTTTCTTAG
 641 CGTGTAACTTGTGTAGCAGCACAGGGCCCACACTTAGAAGGACCCCACACTTGGTTCAAGGCTCTGCTATAGCGGAAATT
 721 CTTAATAATGTTTGAAGAAGGGCCCCATGATTTCATTTTGTGCTGAGCCCTCAAAATTATGTCTGTTTCGTGGTGGGAAA
 801 TATCCTATGTTTTCTTGCTCAAACACCTTTCTCTCTGAAAGCAGAAAAAGGCACTGATATAAAGGGAAGAGAAGGAGGCT
 881 CACCGGAGGGAAGAGAACATAGTGAAGATTCCCGCCTTTGGGGAGGTCTGGACCACCCAGGGCCTCCACTGCCACCTTGG
 961 CTGGCAAGGGAGAAATGTGTTGTGTTGTCTTAGCTTTAAAACAGTCACAGTTCTTGCTCTATCATAGATGAACAAATACT
1041 TTCTTGATCATTCTGTAAGACCAGGAGGTTGGTAAGAGTGACTAACCAGCCTAACTTTAATACACATGTATAAAGATGTT
1121 CACAGAGAAAGATGCTCTGTAGAGAATTTGCTACCGAAGTTGGCTCAAGAATTTGTTTTTAGTGTTATTTACCAAGATTA
1201 GGACGTCAGTGGCTTAAATTCTTTGAATTCTTTTCAAGGACTGCAAGATTATTTGATAAAGAGTAGCATGAATCTTGTGC
1281 TCTAATATTACACAGTAAGTTCAAAGAAAGGATGTAAGTCAAAGACTTGTTACATAGAGGGAAAATGGACTGGGATAGAG
1361 GACAGACTGATAGTTTCTTTCTTTCATATCACATGTATAGAGAAATAATTATATCAGAAACTCACAAACCTAGACATGGA
1441 AAAACAGATTACTGTCTATTGTCAGCATCATTTTCATCTGTAAGTCACTACTGGAATATATTTTTCTTTTAATTTCCAGT
1521 GACTTTAGAATACACACAGTTTTTCCGACTTTTCAAAAATTTGATTAAATGGTTTTATAGTATAATATTGGGACCCCATA
1601 CCGTTAGCCCTTGTATGTATACCAACACTGCCAAAGTAAAACATTAGGTCAGGCATGGTGGCTCAGGCCTGTAATCCCAG
1681 CATTTTGGGAGGCTGAGGCAAGTGGATAACTTGAGGTCATGAGTTCGAAACCAGCCTGGCCAAAACAGTGAAACCCCGTC
1761 TCTACTAAAAATACAAAATTAGCCAGATGTGGTGGCGCACACCTGTAATCCCAGCTACTCAGGAAGCTGAGGCAGGAAAA
1841 TCGCTTGAACCTGGGAGGTGGAAGTTGCAGTGAGCCGAGATCGCACCACTGCACTCCAGCCTGGGTGACAAGAGCGAAAC
1921 TCCATCTCAAAAAAAAAAAAAAAACCAAAGTGAAACACTAAAAATTCCCTATAGATATATTCCAGGAAATATTTTAATTG
2001 GGCTGATTTTAATTAGGCTGTATCATTGATGATTACTGGAATCGATTTTATGTCTTTTGTATTTTAATCACTTGAGTTAA
2081 TCAACCACTGGCAAATCCCATTTGACAAAGATTAGCATTGTAAAAAACAGATACTGTGGTAGATTTCTAGAAATTCATTC
2161 ACATTTAAGACTTCTAAAATGGAATAATAGCCTTTTGTTTTTCATGAGCATATTCGCACCCCTATATGAATTACAGCATT
2241 TAAAGTTCAAAATCAGTAACTTTTAATCTAGGAAATTGAAAAATATTAAGTTGCAAAGCAAAAAAAGGTATTTTCTTGAA
2321 AATACTATTTAATGTTTAACTAGACTATAGGTAGTTCCTTAAGGTTGTTTGACCTGAAGTGGAGTTGGGTTTGGAAGCTG
2401 GTGCCCAGTTGGTGTGGAGTGTGTAGTTTTGTTATGAAAGTTCTCTACCACCTACCTGTGTGAGTGACACCAACATCCAG
2481 ATGTCACAGCTCTCCAGAGCTAGTCAGAAGAGAAATCAAATTAGTGTTTAAACCCATTTGCATATTGACTTGTCAGTACC
2561 TTTAACTCAATTTAATATAACAAGAAATCGTAAAATACTTATAACCTATCTTAGAGAAATGAGTGCTGGTTTTGAGAGTT
2641 GTTTTTTAACTGAAAGATTATTTCTAGATGGGTAGTGCTTTGTGCTGGTTTCTGCTTCCATATATTTCCCAGTCATTTTA
2721 ATTAGAGAAGATACTCTATGGTAGAACTAAGGCCTTTCCTTTCTTGGCCAAAGTCTTTACCCTATTTAACCCTTTGTATA
2801 TTTCTGACTGCTCACTGTTCATATTATAGGGGACCAGATTTGTAATATAGAATTCTCCATAACATGAATGAAATTAATTC
2881 TGTCCAAGCCAGCATGGTGGCTTCATATTAAGTAGTAACAGAAGTCTGAACAATTGGATAAATTTGACTTCCAAGACAGC
2961 TAAACTTTTCAACTGCAATTTTAAAAACTACACTACACTGTTATAGTTAATCTGACAAAAATGTCCTCAAAGAGTACTTT
3041 ATTTTATTTAAAGCATCTGTTTAATTCAACCTTTAATAATTTTGCAAAGAAGGGTATGTGTGTATTTTAATATAGCCTGA
3121 CCTGAATTTATATGTTTTTAGCTTTAGTATTTAACTTTTTGTAACAAATAAACCTTTTTTAAAACAAGTTTAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uugUUGUUUAGGGUCAGAUGGa 5'
             ||||:||: | |||||:: 
Target 5' aaaAACAGATTACTGTCTATTg 3'
 1440 - 1461 139.00 -12.20
2 
miRNA  3' uuguugUUUAGGGUCAGAUGGa 5'
                ||:|:|   |||||| 
Target 5' ttatgaAAGTTC---TCTACCa 3'
 2432 - 2450 124.00 -8.40
3 
miRNA  3' uuguUGUUUAGGGUCAGAUGGa 5'
              |||: ||::: ||||:| 
Target 5' agtcACAGTTCTTGCTCTATCa 3'
 1003 - 1024 118.00 -11.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM1634383 7 COSMIC
COSN31513663 15 COSMIC
COSN31567009 22 COSMIC
COSN31568437 48 COSMIC
COSN31564312 85 COSMIC
COSN31605179 131 COSMIC
COSN26561762 177 COSMIC
COSN28765209 179 COSMIC
COSN19658154 323 COSMIC
COSN21567709 500 COSMIC
COSN28613015 744 COSMIC
COSN26731492 886 COSMIC
COSN30587483 901 COSMIC
COSN16147367 979 COSMIC
COSN17181648 1431 COSMIC
COSN19062583 1911 COSMIC
COSN20101530 1945 COSMIC
COSN21846639 2217 COSMIC
COSN14783959 2524 COSMIC
COSN24531906 2658 COSMIC
COSN25724368 2849 COSMIC
COSN31962433 2891 COSMIC
COSN26750718 3169 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs183222273 4 dbSNP
rs778700145 5 dbSNP
rs747123782 6 dbSNP
rs770844738 12 dbSNP
rs764753665 16 dbSNP
rs746140954 18 dbSNP
rs769976895 22 dbSNP
rs202048839 23 dbSNP
rs760302751 27 dbSNP
rs1221368052 28 dbSNP
rs113955811 31 dbSNP
rs1302600036 36 dbSNP
rs1179792898 37 dbSNP
rs1312213689 38 dbSNP
rs763216091 40 dbSNP
rs374326541 45 dbSNP
rs774656499 51 dbSNP
rs1342909728 57 dbSNP
rs1044033156 61 dbSNP
rs749966875 62 dbSNP
rs1405188860 65 dbSNP
rs1429605315 67 dbSNP
rs749789793 71 dbSNP
rs1005475801 81 dbSNP
rs554141957 82 dbSNP
rs186508280 84 dbSNP
rs542074449 85 dbSNP
rs1801904 97 dbSNP
rs757956504 98 dbSNP
rs1314081980 100 dbSNP
rs556049949 113 dbSNP
rs896510927 124 dbSNP
rs1320964988 127 dbSNP
rs1012708259 129 dbSNP
rs1045161814 139 dbSNP
rs14612 147 dbSNP
rs576090781 158 dbSNP
rs898650200 159 dbSNP
rs995726185 163 dbSNP
rs571248739 165 dbSNP
rs1208350229 166 dbSNP
rs951637963 172 dbSNP
rs6697 179 dbSNP
rs1167561967 185 dbSNP
rs754880480 186 dbSNP
rs1462392676 187 dbSNP
rs985369527 191 dbSNP
rs1411908433 196 dbSNP
rs1462956378 197 dbSNP
rs781057052 207 dbSNP
rs1157748291 208 dbSNP
rs957337000 213 dbSNP
rs1252225720 218 dbSNP
rs1177484492 224 dbSNP
rs1487961993 226 dbSNP
rs564985368 228 dbSNP
rs965742014 230 dbSNP
rs989030314 233 dbSNP
rs527324068 241 dbSNP
rs950107605 253 dbSNP
rs1267476899 255 dbSNP
rs921742862 259 dbSNP
rs1226613591 263 dbSNP
rs1045859792 268 dbSNP
rs1470838905 270 dbSNP
rs927241741 301 dbSNP
rs747833098 309 dbSNP
rs62364385 310 dbSNP
rs1328290367 311 dbSNP
rs879037198 311 dbSNP
rs76643686 312 dbSNP
rs771218932 317 dbSNP
rs1176732378 322 dbSNP
rs1319216716 323 dbSNP
rs1450981184 325 dbSNP
rs1407907160 327 dbSNP
rs968268670 328 dbSNP
rs1432193943 329 dbSNP
rs1335917199 332 dbSNP
rs560437336 332 dbSNP
rs1336115100 339 dbSNP
rs888013669 341 dbSNP
rs12515378 348 dbSNP
rs1371317850 350 dbSNP
rs1227812663 352 dbSNP
rs1468779513 370 dbSNP
rs1203374688 372 dbSNP
rs12351 374 dbSNP
rs1325977313 382 dbSNP
rs76881960 385 dbSNP
rs1278374184 386 dbSNP
rs997851183 389 dbSNP
rs1184634737 390 dbSNP
rs772133905 397 dbSNP
rs1295878325 401 dbSNP
rs1384350556 409 dbSNP
rs889428968 414 dbSNP
rs776035594 416 dbSNP
rs1045552327 418 dbSNP
rs898600564 431 dbSNP
rs138158782 440 dbSNP
rs1032700883 448 dbSNP
rs1430778855 477 dbSNP
rs957510943 478 dbSNP
rs1262406221 484 dbSNP
rs1181325193 492 dbSNP
rs368595180 506 dbSNP
rs988764100 508 dbSNP
rs1020097613 513 dbSNP
rs1341730332 515 dbSNP
rs1249935760 518 dbSNP
rs1396954491 519 dbSNP
rs551621580 521 dbSNP
rs1327509022 525 dbSNP
rs1326798291 533 dbSNP
rs1353915113 535 dbSNP
rs113237047 538 dbSNP
rs966098788 538 dbSNP
rs1353080843 547 dbSNP
rs1314187085 561 dbSNP
rs1405454209 566 dbSNP
rs971224064 568 dbSNP
rs967796854 571 dbSNP
rs979172022 573 dbSNP
rs923738860 574 dbSNP
rs956548326 575 dbSNP
rs992028327 577 dbSNP
rs1340523465 579 dbSNP
rs917879031 580 dbSNP
rs981502383 582 dbSNP
rs948029310 585 dbSNP
rs1045098867 597 dbSNP
rs776149271 608 dbSNP
rs919935016 611 dbSNP
rs182513265 612 dbSNP
rs1188786881 619 dbSNP
rs937471684 626 dbSNP
rs187977965 643 dbSNP
rs887238144 652 dbSNP
rs1197891373 656 dbSNP
rs944227781 673 dbSNP
rs1223861194 678 dbSNP
rs909254766 685 dbSNP
rs1231931560 691 dbSNP
rs764441077 693 dbSNP
rs1337586102 702 dbSNP
rs1489601376 710 dbSNP
rs1414924083 714 dbSNP
rs554179178 715 dbSNP
rs1326525713 720 dbSNP
rs1392906961 723 dbSNP
rs900112030 735 dbSNP
rs1396874576 737 dbSNP
rs567581429 745 dbSNP
rs191166149 748 dbSNP
rs1476179299 750 dbSNP
rs762032348 755 dbSNP
rs561115724 756 dbSNP
rs903522187 769 dbSNP
rs1425286943 773 dbSNP
rs1184318272 781 dbSNP
rs547152758 781 dbSNP
rs1267026754 784 dbSNP
rs1212238920 785 dbSNP
rs1465734806 786 dbSNP
rs572881926 787 dbSNP
rs1006678563 790 dbSNP
rs556421071 791 dbSNP
rs1277281853 806 dbSNP
rs1466013332 807 dbSNP
rs761416842 808 dbSNP
rs1247261921 810 dbSNP
rs1484775280 811 dbSNP
rs991974425 819 dbSNP
rs1268004537 821 dbSNP
rs762956700 825 dbSNP
rs1432634434 827 dbSNP
rs1174425840 829 dbSNP
rs767088080 838 dbSNP
rs1458025806 847 dbSNP
rs1428709254 851 dbSNP
rs1025295994 852 dbSNP
rs532866517 853 dbSNP
rs1386834933 858 dbSNP
rs1020232922 860 dbSNP
rs1439080431 861 dbSNP
rs1294592344 863 dbSNP
rs1382803676 867 dbSNP
rs1367567108 883 dbSNP
rs576199725 885 dbSNP
rs981114184 886 dbSNP
rs760444026 888 dbSNP
rs1228555147 896 dbSNP
rs1267120600 899 dbSNP
rs1192113762 905 dbSNP
rs971192994 912 dbSNP
rs545174511 915 dbSNP
rs1208589062 919 dbSNP
rs1341825461 932 dbSNP
rs1281475167 933 dbSNP
rs765978246 935 dbSNP
rs1206402056 948 dbSNP
rs1350915635 949 dbSNP
rs558399628 956 dbSNP
rs1294536944 961 dbSNP
rs541688648 962 dbSNP
rs1372984765 965 dbSNP
rs1303891281 966 dbSNP
rs1429853420 969 dbSNP
rs944175601 979 dbSNP
rs1320349055 980 dbSNP
rs1208776624 982 dbSNP
rs78379776 983 dbSNP
rs1448442592 985 dbSNP
rs578182601 994 dbSNP
rs940712504 1005 dbSNP
rs972258929 1017 dbSNP
rs1165413874 1019 dbSNP
rs748000145 1020 dbSNP
rs544137495 1022 dbSNP
rs1194657035 1035 dbSNP
rs1447141560 1039 dbSNP
rs1279143389 1040 dbSNP
rs1457313767 1041 dbSNP
rs1162808633 1050 dbSNP
rs903512289 1056 dbSNP
rs1213795295 1060 dbSNP
rs560511062 1070 dbSNP
rs1384147575 1072 dbSNP
rs1359748004 1073 dbSNP
rs1271932453 1083 dbSNP
rs1431558354 1093 dbSNP
rs183425513 1096 dbSNP
rs866061779 1133 dbSNP
rs1354838952 1137 dbSNP
rs1318708374 1138 dbSNP
rs1000524509 1140 dbSNP
rs1050548232 1143 dbSNP
rs910752607 1156 dbSNP
rs942412846 1157 dbSNP
rs1054216722 1160 dbSNP
rs1453775221 1167 dbSNP
rs892771559 1170 dbSNP
rs1169054994 1171 dbSNP
rs1009921236 1183 dbSNP
rs1472764952 1193 dbSNP
rs149637176 1205 dbSNP
rs1244696621 1206 dbSNP
rs755842620 1222 dbSNP
rs1257840924 1239 dbSNP
rs1002831496 1249 dbSNP
rs969629573 1252 dbSNP
rs1034589971 1256 dbSNP
rs980678872 1258 dbSNP
rs563185733 1264 dbSNP
rs779237089 1274 dbSNP
rs1416755752 1281 dbSNP
rs187227485 1283 dbSNP
rs962129138 1292 dbSNP
rs1267039007 1300 dbSNP
rs192098830 1307 dbSNP
rs113244386 1315 dbSNP
rs923311566 1320 dbSNP
rs954949145 1329 dbSNP
rs548700323 1335 dbSNP
rs986405611 1336 dbSNP
rs1416361963 1348 dbSNP
rs1423230637 1349 dbSNP
rs138569996 1352 dbSNP
rs1364463186 1356 dbSNP
rs1176214691 1357 dbSNP
rs977246610 1360 dbSNP
rs1455375828 1363 dbSNP
rs910674919 1368 dbSNP
rs1234355522 1372 dbSNP
rs921410315 1374 dbSNP
rs932848869 1376 dbSNP
rs936874762 1397 dbSNP
rs570070795 1398 dbSNP
rs1235208162 1401 dbSNP
rs1335614256 1409 dbSNP
rs1054587256 1414 dbSNP
rs1043310629 1423 dbSNP
rs549335749 1426 dbSNP
rs1375833982 1437 dbSNP
rs1395976779 1439 dbSNP
rs527751585 1456 dbSNP
rs1280449874 1462 dbSNP
rs936326097 1487 dbSNP
rs1392919324 1492 dbSNP
rs1328590137 1493 dbSNP
rs1462442695 1496 dbSNP
rs1052020368 1500 dbSNP
rs756393194 1509 dbSNP
rs1013297488 1515 dbSNP
rs1046579309 1525 dbSNP
rs1060488 1537 dbSNP
rs547822001 1547 dbSNP
rs1251044636 1548 dbSNP
rs1215423486 1549 dbSNP
rs1468862598 1550 dbSNP
rs1002471072 1554 dbSNP
rs567710333 1557 dbSNP
rs906901633 1580 dbSNP
rs1002751224 1581 dbSNP
rs1055733022 1583 dbSNP
rs536639356 1586 dbSNP
rs1015566559 1593 dbSNP
rs1205158618 1594 dbSNP
rs894270289 1595 dbSNP
rs184590081 1596 dbSNP
rs1482767222 1597 dbSNP
rs921390220 1600 dbSNP
rs569913522 1603 dbSNP
rs780364587 1604 dbSNP
rs1252517982 1610 dbSNP
rs1433728045 1611 dbSNP
rs993574974 1614 dbSNP
rs1030253716 1616 dbSNP
rs538480588 1624 dbSNP
rs1180158399 1626 dbSNP
rs954715150 1627 dbSNP
rs1480921421 1642 dbSNP
rs1210361779 1646 dbSNP
rs986767581 1646 dbSNP
rs1346035370 1658 dbSNP
rs1282853440 1659 dbSNP
rs1235539102 1667 dbSNP
rs910819727 1670 dbSNP
rs1294145219 1674 dbSNP
rs958562453 1678 dbSNP
rs926134634 1679 dbSNP
rs1363374901 1681 dbSNP
rs1298280023 1705 dbSNP
rs989646069 1707 dbSNP
rs558686556 1712 dbSNP
rs1373259864 1715 dbSNP
rs769225374 1727 dbSNP
rs868184774 1728 dbSNP
rs1299076210 1732 dbSNP
rs1053301621 1736 dbSNP
rs1168165863 1741 dbSNP
rs1430245196 1747 dbSNP
rs977177253 1754 dbSNP
rs1263952673 1755 dbSNP
rs928260861 1757 dbSNP
rs559624997 1758 dbSNP
rs755424281 1759 dbSNP
rs1287224445 1784 dbSNP
rs1480545236 1786 dbSNP
rs1230176018 1789 dbSNP
rs894373094 1789 dbSNP
rs75532002 1797 dbSNP
rs1037531565 1798 dbSNP
rs1232198972 1810 dbSNP
rs1353142838 1813 dbSNP
rs897668677 1816 dbSNP
rs1396376524 1826 dbSNP
rs993501501 1829 dbSNP
rs765519349 1832 dbSNP
rs1227948630 1835 dbSNP
rs1252823452 1839 dbSNP
rs1463420665 1842 dbSNP
rs1030394371 1843 dbSNP
rs187806869 1844 dbSNP
rs1251194576 1850 dbSNP
rs1474306702 1851 dbSNP
rs1490516271 1855 dbSNP
rs193284105 1867 dbSNP
rs1423380655 1877 dbSNP
rs1432785684 1878 dbSNP
rs762710948 1883 dbSNP
rs958312866 1884 dbSNP
rs112714866 1885 dbSNP
rs990174066 1904 dbSNP
rs965370823 1906 dbSNP
rs1285456858 1910 dbSNP
rs1307888945 1915 dbSNP
rs1365694044 1917 dbSNP
rs1304576442 1928 dbSNP
rs1392961102 1928 dbSNP
rs1406192763 1928 dbSNP
rs1253063599 1929 dbSNP
rs1362328577 1929 dbSNP
rs1362387010 1929 dbSNP
rs1469773780 1929 dbSNP
rs34389233 1929 dbSNP
rs397710500 1929 dbSNP
rs1291269156 1930 dbSNP
rs1366519407 1931 dbSNP
rs1184381298 1943 dbSNP
rs1021100078 1945 dbSNP
rs1214794800 1946 dbSNP
rs1297532497 1947 dbSNP
rs1192239220 1951 dbSNP
rs966885865 1952 dbSNP
rs1470246882 1960 dbSNP
rs184346419 1972 dbSNP
rs977139694 1985 dbSNP
rs1291348474 2003 dbSNP
rs1227585517 2005 dbSNP
rs1292363446 2014 dbSNP
rs928354140 2016 dbSNP
rs1361470279 2018 dbSNP
rs576649094 2026 dbSNP
rs11557538 2028 dbSNP
rs1028392661 2029 dbSNP
rs545288605 2044 dbSNP
rs1302416673 2070 dbSNP
rs1438572798 2075 dbSNP
rs1033101269 2076 dbSNP
rs1324258019 2079 dbSNP
rs991165916 2085 dbSNP
rs565439151 2086 dbSNP
rs1383064057 2092 dbSNP
rs879162314 2099 dbSNP
rs551205558 2107 dbSNP
rs1420549735 2112 dbSNP
rs956215463 2116 dbSNP
rs1192180679 2119 dbSNP
rs868257587 2121 dbSNP
rs1247848991 2122 dbSNP
rs189626302 2123 dbSNP
rs949068329 2128 dbSNP
rs1187271279 2132 dbSNP
rs139839676 2135 dbSNP
rs982157806 2158 dbSNP
rs1231870589 2164 dbSNP
rs1346997790 2166 dbSNP
rs1037582622 2172 dbSNP
rs751147916 2177 dbSNP
rs1168534746 2183 dbSNP
rs752664335 2191 dbSNP
rs897642386 2191 dbSNP
rs1048182146 2204 dbSNP
rs888275591 2205 dbSNP
rs1386462113 2211 dbSNP
rs1427077218 2216 dbSNP
rs758923000 2217 dbSNP
rs1426469015 2227 dbSNP
rs764071673 2227 dbSNP
rs1348781682 2233 dbSNP
rs561352187 2235 dbSNP
rs1474717070 2238 dbSNP
rs1051577089 2239 dbSNP
rs1036934314 2246 dbSNP
rs75608693 2249 dbSNP
rs1208452185 2253 dbSNP
rs550119412 2256 dbSNP
rs1279080556 2269 dbSNP
rs77390475 2273 dbSNP
rs1315431621 2290 dbSNP
rs1384984452 2298 dbSNP
rs1226518925 2300 dbSNP
rs1017597808 2309 dbSNP
rs368877830 2324 dbSNP
rs1280151284 2326 dbSNP
rs1321126607 2328 dbSNP
rs372491383 2332 dbSNP
rs755994749 2339 dbSNP
rs1355061870 2344 dbSNP
rs1216810991 2349 dbSNP
rs1311354701 2360 dbSNP
rs750530639 2364 dbSNP
rs1270194606 2365 dbSNP
rs1450482209 2381 dbSNP
rs889794965 2382 dbSNP
rs1328642901 2384 dbSNP
rs1463694926 2385 dbSNP
rs1426471906 2398 dbSNP
rs1188373629 2404 dbSNP
rs1172153144 2405 dbSNP
rs1011118184 2406 dbSNP
rs1416694062 2407 dbSNP
rs1185268097 2410 dbSNP
rs1021229363 2413 dbSNP
rs6815 2415 dbSNP
rs1474093082 2426 dbSNP
rs1259992584 2429 dbSNP
rs75616953 2435 dbSNP
rs1334181155 2437 dbSNP
rs1291520220 2438 dbSNP
rs1412453548 2441 dbSNP
rs1380193294 2453 dbSNP
rs181133310 2457 dbSNP
rs12089 2464 dbSNP
rs758648677 2465 dbSNP
rs1440512418 2474 dbSNP
rs1403075661 2476 dbSNP
rs1402813585 2478 dbSNP
rs534502512 2485 dbSNP
rs116573897 2493 dbSNP
rs991653733 2498 dbSNP
rs184902304 2499 dbSNP
rs1386044839 2505 dbSNP
rs1162125797 2516 dbSNP
rs7622 2524 dbSNP
rs963391181 2528 dbSNP
rs972034044 2534 dbSNP
rs1445736457 2536 dbSNP
rs1239795220 2541 dbSNP
rs1179107702 2576 dbSNP
rs1283484053 2581 dbSNP
rs1223926716 2582 dbSNP
rs1322520908 2590 dbSNP
rs376810016 2591 dbSNP
rs1222407026 2599 dbSNP
rs1379503004 2611 dbSNP
rs926249214 2614 dbSNP
rs919165352 2620 dbSNP
rs556883074 2623 dbSNP
rs576673699 2630 dbSNP
rs574319800 2646 dbSNP
rs929250749 2652 dbSNP
rs1051545548 2653 dbSNP
rs59723543 2655 dbSNP
rs1291261472 2657 dbSNP
rs1327427619 2658 dbSNP
rs943434922 2669 dbSNP
rs1350096610 2672 dbSNP
rs1157842097 2675 dbSNP
rs909657808 2681 dbSNP
rs535184517 2683 dbSNP
rs1039531675 2688 dbSNP
rs939820984 2694 dbSNP
rs893778599 2696 dbSNP
rs901021461 2701 dbSNP
rs933860985 2703 dbSNP
rs1192984879 2704 dbSNP
rs1208684976 2706 dbSNP
rs1237366505 2726 dbSNP
rs574725399 2727 dbSNP
rs565568591 2728 dbSNP
rs1042435076 2729 dbSNP
rs552620266 2729 dbSNP
rs1423051517 2730 dbSNP
rs544635752 2730 dbSNP
rs1183794615 2731 dbSNP
rs575448275 2731 dbSNP
rs200908250 2732 dbSNP
rs1049673376 2733 dbSNP
rs1287128325 2737 dbSNP
rs768583814 2739 dbSNP
rs1003829979 2752 dbSNP
rs1304127175 2753 dbSNP
rs1387874467 2754 dbSNP
rs1367618436 2758 dbSNP
rs1176619702 2767 dbSNP
rs1397700016 2771 dbSNP
rs1035150952 2774 dbSNP
rs1362122872 2783 dbSNP
rs1298545323 2790 dbSNP
rs959806393 2792 dbSNP
rs891852549 2793 dbSNP
rs781754788 2808 dbSNP
rs1333235232 2817 dbSNP
rs1433706039 2824 dbSNP
rs188963096 2826 dbSNP
rs1012643386 2832 dbSNP
rs1191622737 2835 dbSNP
rs1489379912 2836 dbSNP
rs1264256822 2853 dbSNP
rs748593959 2860 dbSNP
rs1002187876 2865 dbSNP
rs769613303 2869 dbSNP
rs3184188 2880 dbSNP
rs973026480 2892 dbSNP
rs1307452547 2895 dbSNP
rs561387347 2898 dbSNP
rs1348651459 2901 dbSNP
rs1298489541 2920 dbSNP
rs959011380 2923 dbSNP
rs918964186 2932 dbSNP
rs1399710406 2935 dbSNP
rs950629720 2937 dbSNP
rs909559658 2941 dbSNP
rs1353908214 2957 dbSNP
rs1228022688 2963 dbSNP
rs181651981 2967 dbSNP
rs1424445155 2968 dbSNP
rs1284119381 2976 dbSNP
rs911689424 2977 dbSNP
rs943216134 2979 dbSNP
rs143291303 2982 dbSNP
rs1201439130 3004 dbSNP
rs563651169 3013 dbSNP
rs1217888965 3019 dbSNP
rs915293384 3025 dbSNP
rs186229312 3027 dbSNP
rs1319312712 3038 dbSNP
rs11557537 3042 dbSNP
rs1278279701 3046 dbSNP
rs1243561309 3057 dbSNP
rs1338359481 3059 dbSNP
rs1050104516 3060 dbSNP
rs1396429313 3076 dbSNP
rs1438954711 3080 dbSNP
rs1042403507 3093 dbSNP
rs1248988862 3097 dbSNP
rs11952481 3098 dbSNP
rs1003756525 3114 dbSNP
rs565625348 3131 dbSNP
rs528300019 3134 dbSNP
rs1057135204 3136 dbSNP
rs891800434 3146 dbSNP
rs770731146 3149 dbSNP
rs895285814 3153 dbSNP
rs1418917325 3160 dbSNP
rs547955501 3161 dbSNP
rs1017128967 3162 dbSNP
rs1171855097 3180 dbSNP
rs370978447 3186 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uuguuguuuagggucAGAUGGa 5'
                         |||||| 
Target 5' --------------cUCUACCa 3'
 		1 - 8
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000379982.3 | 3UTR | CUCUACCACCUACCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
66 hsa-miR-3529-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT068541 NHLRC3 NHL repeat containing 3 2 6
MIRT094173 PCGF3 polycomb group ring finger 3 2 6
MIRT100107 ABT1 activator of basal transcription 1 2 8
MIRT120933 PDE12 phosphodiesterase 12 2 8
MIRT179060 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 6
MIRT202049 ZSWIM1 zinc finger SWIM-type containing 1 2 2
MIRT215733 C5ORF51 chromosome 5 open reading frame 51 2 10
MIRT254619 HIC2 HIC ZBTB transcriptional repressor 2 2 2
MIRT266230 PEX11B peroxisomal biogenesis factor 11 beta 2 2
MIRT297452 SLC20A1 solute carrier family 20 member 1 2 4
MIRT315453 SLC16A10 solute carrier family 16 member 10 2 2
MIRT442138 C3orf17 nucleolus and neural progenitor protein 2 2
MIRT453879 IFRD1 interferon related developmental regulator 1 2 12
MIRT456259 TDRKH tudor and KH domain containing 2 12
MIRT456413 MTRF1L mitochondrial translational release factor 1 like 2 2
MIRT459730 RRM1 ribonucleotide reductase catalytic subunit M1 2 2
MIRT461475 METTL1 methyltransferase like 1 2 2
MIRT463790 YBX1 Y-box binding protein 1 2 6
MIRT464032 WASL Wiskott-Aldrich syndrome like 2 2
MIRT464207 VGLL4 vestigial like family member 4 2 2
MIRT466713 SYNJ2BP synaptojanin 2 binding protein 2 2
MIRT467958 SLC16A1 solute carrier family 16 member 1 2 4
MIRT469225 RHOBTB3 Rho related BTB domain containing 3 2 2
MIRT473960 LRRC58 leucine rich repeat containing 58 2 2
MIRT475310 IFNLR1 interferon lambda receptor 1 2 2
MIRT476946 FAM83G family with sequence similarity 83 member G 2 4
MIRT477746 EDN1 endothelin 1 2 2
MIRT478261 DDX19B DEAD-box helicase 19B 2 2
MIRT478681 CSRP2 cysteine and glycine rich protein 2 2 4
MIRT490256 HAAO 3-hydroxyanthranilate 3,4-dioxygenase 2 2
MIRT493290 LNPEP leucyl and cystinyl aminopeptidase 2 2
MIRT493565 HSPA5 heat shock protein family A (Hsp70) member 5 2 2
MIRT495961 TBC1D19 TBC1 domain family member 19 2 2
MIRT497107 BEST3 bestrophin 3 2 2
MIRT498349 CISD1 CDGSH iron sulfur domain 1 2 2
MIRT500784 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 8
MIRT501092 SLC5A6 solute carrier family 5 member 6 2 4
MIRT505308 TPD52 tumor protein D52 2 2
MIRT511108 NFIB nuclear factor I B 2 4
MIRT512736 CD59 CD59 molecule (CD59 blood group) 2 4
MIRT514270 ZNF519 zinc finger protein 519 2 2
MIRT514603 NDUFA12 NADH:ubiquinone oxidoreductase subunit A12 2 4
MIRT515379 RPL7 ribosomal protein L7 2 2
MIRT518565 GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 2 2
MIRT520460 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT529766 SF3B1 splicing factor 3b subunit 1 2 2
MIRT538006 DNAL1 dynein axonemal light chain 1 2 2
MIRT538251 CUL3 cullin 3 2 4
MIRT543778 RBM12B RNA binding motif protein 12B 2 4
MIRT546204 TOR1AIP2 torsin 1A interacting protein 2 2 2
MIRT547202 PARP1 poly(ADP-ribose) polymerase 1 2 2
MIRT548441 ELMOD2 ELMO domain containing 2 2 2
MIRT551635 TRUB1 TruB pseudouridine synthase family member 1 2 4
MIRT553335 TSC22D2 TSC22 domain family member 2 2 2
MIRT556170 MCC mutated in colorectal cancers 2 2
MIRT557969 FAM222B family with sequence similarity 222 member B 2 2
MIRT560717 ZNF749 zinc finger protein 749 2 2
MIRT564115 ZYG11B zyg-11 family member B, cell cycle regulator 2 4
MIRT564375 MRPS18B mitochondrial ribosomal protein S18B 2 2
MIRT566934 LIN28B lin-28 homolog B 2 2
MIRT573339 TUBD1 tubulin delta 1 2 2
MIRT607187 SPRY4 sprouty RTK signaling antagonist 4 2 2
MIRT694902 THAP6 THAP domain containing 6 2 2
MIRT698514 TGFBR1 transforming growth factor beta receptor 1 2 2
MIRT704038 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT714583 PRRC1 proline rich coiled-coil 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3529-5p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-3529-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-3529-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-3529-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)

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