ID	Duplex structure	Position	Score	MFE
1	miRNA 3' ugGGAGACUUUCCUUCGu 5' |||:|| |:|| ||| Target 5' ccCCTTTGCAGGGCAGCc 3'	297 - 314	120.00	-17.20
2	miRNA 3' ugggaGACUU--UCCUUCGu 5' |||:| :||:||| Target 5' tttagCTGGAGTGGGGAGCa 3'	225 - 244	119.00	-15.00
3	miRNA 3' uggGAGACUUUCCUUCGu 5' | | | :|||||: Target 5' acaCCCAGCCGGGAAGTc 3'	373 - 390	111.00	-10.00

Mutant ID	Mutant Position	Mutant Source
COSN14391941	31	COSMIC
COSN21231984	86	COSMIC
COSN30494675	123	COSMIC
COSN5703299	125	COSMIC
COSN31608943	138	COSMIC
COSN30510494	140	COSMIC
COSN30526781	147	COSMIC
COSN30510778	176	COSMIC
COSM8543098	238	COSMIC
COSM1756166	251	COSMIC
COSM6874341	261	COSMIC
COSM9924070	273	COSMIC
COSM1674487	291	COSMIC
COSM9706799	299	COSMIC
COSM5438516	300	COSMIC
COSM1636180	308	COSMIC
COSM2774780	316	COSMIC
COSM4152286	335	COSMIC
COSM6027616	341	COSMIC
COSM9747403	341	COSMIC
COSM4485757	351	COSMIC
COSM5932424	354	COSMIC
COSM8765861	361	COSMIC
COSM8593715	363	COSMIC
COSM4644929	366	COSMIC
COSM8960282	367	COSMIC
COSM753484	373	COSMIC
COSM9518607	384	COSMIC
COSM3848510	391	COSMIC
COSM4449465	408	COSMIC
COSM6281414	416	COSMIC
COSN30743166	488	COSMIC
COSN24391789	631	COSMIC
COSN2322900	662	COSMIC
COSM6055343	786	COSMIC
COSM4588822	789	COSMIC
COSM1108787	804	COSMIC
COSM8992078	804	COSMIC
COSM8316710	823	COSMIC
COSM9741469	839	COSMIC
COSM7917284	840	COSMIC
COSM1108788	841	COSMIC
COSM4389583	842	COSMIC
COSM487442	843	COSMIC
COSM455927	844	COSMIC
COSM7555045	861	COSMIC
COSM1132491	874	COSMIC
COSM4528072	876	COSMIC
COSM6183761	879	COSMIC
COSM9665766	896	COSMIC
COSN26634551	1028	COSMIC
COSM3780002	1130	COSMIC
COSM753483	1136	COSMIC
COSM7794217	1137	COSMIC
COSM8691773	1149	COSMIC
COSM6550085	1154	COSMIC
COSM1108789	1160	COSMIC
COSM9207336	1160	COSMIC
COSM240730	1172	COSMIC
COSM1215596	1180	COSMIC
COSM240731	1180	COSMIC
COSM455928	1200	COSMIC
COSM7869171	1202	COSMIC
COSM4163827	1210	COSMIC
COSM4549323	1211	COSMIC
COSM7220888	1217	COSMIC
COSM4546402	1218	COSMIC
COSM6438426	1219	COSMIC
COSM5411056	1236	COSMIC
COSM9749106	1246	COSMIC
COSN21125118	1272	COSMIC
COSN30511462	1277	COSMIC
COSN30154472	1295	COSMIC
COSN30493247	1297	COSMIC
COSN30148840	1298	COSMIC
COSN30147201	1306	COSMIC
COSN26992101	1329	COSMIC
COSN28191333	1346	COSMIC
COSN24945527	1460	COSMIC
COSN6390170	1555	COSMIC
COSN14947891	1630	COSMIC
COSN20298601	1882	COSMIC
COSN17542590	2764	COSMIC
COSN9711355	3967	COSMIC
COSN25750820	4115	COSMIC
COSN9283040	4228	COSMIC
COSN14948088	4492	COSMIC
COSN16040906	4601	COSMIC
COSN15589291	4705	COSMIC
COSN2322902	5254	COSMIC
COSN6390172	5525	COSMIC
rs1322045	1630	GWAS
rs3750437	4492	GWAS
rs10814275	5708	GWAS

Mutant ID	Mutant Position	Mutant Source
rs763493130	4	dbSNP
rs1266055922	8	dbSNP
rs1289442216	9	dbSNP
rs569827733	11	dbSNP
rs1345932316	12	dbSNP
rs775091270	16	dbSNP
rs760852828	22	dbSNP
rs760049994	23	dbSNP
rs763816126	27	dbSNP
rs753616593	31	dbSNP
rs756953349	32	dbSNP
rs1482264604	36	dbSNP
rs765169753	37	dbSNP
rs750209266	38	dbSNP
rs1387451001	51	dbSNP
rs1292215988	52	dbSNP
rs1455136126	57	dbSNP
rs1322627351	62	dbSNP
rs898270774	72	dbSNP
rs1198079234	73	dbSNP
rs1433638822	76	dbSNP
rs529233058	81	dbSNP
rs1186747838	87	dbSNP
rs1002022904	92	dbSNP
rs1268980323	93	dbSNP
rs1033482029	94	dbSNP
rs1214083146	96	dbSNP
rs1002918738	97	dbSNP
rs1036274092	102	dbSNP
rs1305081214	103	dbSNP
rs1200415417	105	dbSNP
rs369297245	112	dbSNP
rs1364076110	113	dbSNP
rs371177398	118	dbSNP
rs765263378	125	dbSNP
rs1383520974	141	dbSNP
rs1399809096	147	dbSNP
rs1171763205	152	dbSNP
rs775323540	154	dbSNP
rs1027271436	156	dbSNP
rs1020906181	160	dbSNP
rs1478112378	183	dbSNP
rs967782258	183	dbSNP
rs1173834626	185	dbSNP
rs1166843440	186	dbSNP
rs1392719264	188	dbSNP
rs1448962516	190	dbSNP
rs1434070939	198	dbSNP
rs548895997	199	dbSNP
rs375973678	200	dbSNP
rs747124022	205	dbSNP
rs985164967	206	dbSNP
rs1440851571	207	dbSNP
rs754946113	215	dbSNP
rs781328012	224	dbSNP
rs202139382	233	dbSNP
rs769972956	234	dbSNP
rs1201386791	238	dbSNP
rs776883977	238	dbSNP
rs778143563	239	dbSNP
rs1277421751	240	dbSNP
rs533987231	241	dbSNP
rs1273082969	244	dbSNP
rs771484856	247	dbSNP
rs774656788	262	dbSNP
rs552928556	264	dbSNP
rs1451891057	266	dbSNP
rs768113608	267	dbSNP
rs1250653597	269	dbSNP
rs1453294361	270	dbSNP
rs1168627747	272	dbSNP
rs776254574	275	dbSNP
rs761595234	276	dbSNP
rs1460353927	284	dbSNP
rs567789321	287	dbSNP
rs1391176952	291	dbSNP
rs373146480	294	dbSNP
rs762596084	296	dbSNP
rs766344453	297	dbSNP
rs554326292	298	dbSNP
rs3750436	300	dbSNP
rs752735628	301	dbSNP
rs756352320	310	dbSNP
rs150505941	315	dbSNP
rs369287451	316	dbSNP
rs1054014272	317	dbSNP
rs1169712428	318	dbSNP
rs771269916	323	dbSNP
rs779327053	330	dbSNP
rs190255781	331	dbSNP
rs893758332	337	dbSNP
rs1467702074	342	dbSNP
rs1476084174	344	dbSNP
rs372946361	350	dbSNP
rs772596408	352	dbSNP
rs1477259431	356	dbSNP
rs776309471	360	dbSNP
rs200332631	363	dbSNP
rs1368881962	364	dbSNP
rs537938874	366	dbSNP
rs1162476827	373	dbSNP
rs376929402	375	dbSNP
rs542521196	377	dbSNP
rs763810922	382	dbSNP
rs370349002	383	dbSNP
rs555637663	384	dbSNP
rs767394535	386	dbSNP
rs752789150	389	dbSNP
rs182933098	391	dbSNP
rs112202528	392	dbSNP
rs994383232	394	dbSNP
rs1273172575	396	dbSNP
rs1293005192	397	dbSNP
rs1333780344	399	dbSNP
rs1208965821	402	dbSNP
rs1262013695	404	dbSNP
rs373884777	405	dbSNP
rs1203984856	406	dbSNP
rs898174333	407	dbSNP
rs1256813849	408	dbSNP
rs1476107571	412	dbSNP
rs757483124	413	dbSNP
rs1027155466	415	dbSNP
rs1473079615	416	dbSNP
rs759719735	419	dbSNP
rs779181155	423	dbSNP
rs73438780	424	dbSNP
rs1303436219	425	dbSNP
rs1054891660	426	dbSNP
rs758848388	434	dbSNP
rs1312728645	439	dbSNP
rs1313674287	444	dbSNP
rs1351459643	449	dbSNP
rs756970945	450	dbSNP
rs1390049081	455	dbSNP
rs765699346	455	dbSNP
rs767144864	462	dbSNP
rs577348596	476	dbSNP
rs1181901528	480	dbSNP
rs1473226573	484	dbSNP
rs1201808755	488	dbSNP
rs776607932	492	dbSNP
rs965051726	492	dbSNP
rs1483353359	495	dbSNP
rs976807271	498	dbSNP
rs923742472	508	dbSNP
rs1213942234	513	dbSNP
rs1336476661	518	dbSNP
rs1266087266	520	dbSNP
rs956652071	528	dbSNP
rs543009682	530	dbSNP
rs1281238074	533	dbSNP
rs1434163516	535	dbSNP
rs1330607338	550	dbSNP
rs761903334	551	dbSNP
rs1171919423	556	dbSNP
rs1000751991	560	dbSNP
rs749975281	562	dbSNP
rs947979379	563	dbSNP
rs1044930831	578	dbSNP
rs139485366	589	dbSNP
rs975434138	597	dbSNP
rs1410567569	608	dbSNP
rs938717681	610	dbSNP
rs921390910	624	dbSNP
rs1300297772	625	dbSNP
rs1245683710	636	dbSNP
rs1193710054	639	dbSNP
rs955725055	644	dbSNP
rs1414271651	646	dbSNP
rs1057440326	647	dbSNP
rs755611055	654	dbSNP
rs1311231272	657	dbSNP
rs1342617629	659	dbSNP
rs987008283	664	dbSNP
rs1317333427	667	dbSNP
rs1270610643	672	dbSNP
rs994622402	677	dbSNP
rs1338641985	679	dbSNP
rs1217423882	681	dbSNP
rs1344207182	686	dbSNP
rs1304303248	691	dbSNP
rs908772059	713	dbSNP
rs1280686396	715	dbSNP
rs187559043	723	dbSNP
rs888588063	729	dbSNP
rs1308729599	736	dbSNP
rs1314725120	739	dbSNP
rs1237711303	745	dbSNP
rs1256015745	749	dbSNP
rs1219453857	751	dbSNP
rs370886353	752	dbSNP
rs375708990	753	dbSNP
rs769494137	761	dbSNP
rs772834908	763	dbSNP
rs1178683257	766	dbSNP
rs1406065347	770	dbSNP
rs116619039	773	dbSNP
rs770579176	774	dbSNP
rs1426450043	776	dbSNP
rs1176950412	778	dbSNP
rs1396959412	782	dbSNP
rs559252593	786	dbSNP
rs75446899	787	dbSNP
rs767449508	788	dbSNP
rs775475769	792	dbSNP
rs1296745666	797	dbSNP
rs551634707	803	dbSNP
rs1243695269	804	dbSNP
rs1207716579	810	dbSNP
rs1441816000	818	dbSNP
rs764212556	822	dbSNP
rs753919612	823	dbSNP
rs757447842	829	dbSNP
rs1363887018	831	dbSNP
rs765447101	837	dbSNP
rs1236352693	839	dbSNP
rs750768999	842	dbSNP
rs758771580	843	dbSNP
rs780563187	844	dbSNP
rs747578513	845	dbSNP
rs755520107	846	dbSNP
rs777178904	848	dbSNP
rs1255011015	852	dbSNP
rs748782932	853	dbSNP
rs1193046266	854	dbSNP
rs1391333935	859	dbSNP
rs770501354	860	dbSNP
rs1447734784	861	dbSNP
rs773985552	863	dbSNP
rs902373792	866	dbSNP
rs1461207843	868	dbSNP
rs1293772945	870	dbSNP
rs1428312184	872	dbSNP
rs745500055	874	dbSNP
rs915087954	881	dbSNP
rs1438081963	882	dbSNP
rs1167405536	883	dbSNP
rs1301989016	884	dbSNP
rs775703868	889	dbSNP
rs763318371	890	dbSNP
rs1000699518	892	dbSNP
rs1179698669	895	dbSNP
rs202020472	895	dbSNP
rs775240015	899	dbSNP
rs1306678779	905	dbSNP
rs367669559	907	dbSNP
rs371428987	908	dbSNP
rs927929748	913	dbSNP
rs939265234	914	dbSNP
rs764512644	916	dbSNP
rs763983340	919	dbSNP
rs778345760	921	dbSNP
rs1185259343	922	dbSNP
rs1419312871	923	dbSNP
rs368980087	925	dbSNP
rs1167466762	929	dbSNP
rs1396238215	931	dbSNP
rs1459536025	933	dbSNP
rs1324709645	935	dbSNP
rs1057137426	938	dbSNP
rs376615535	940	dbSNP
rs192014018	943	dbSNP
rs183778836	950	dbSNP
rs1309545589	952	dbSNP
rs1310863493	953	dbSNP
rs1227888334	957	dbSNP
rs1283147499	958	dbSNP
rs955510816	961	dbSNP
rs1445583249	963	dbSNP
rs1408584985	964	dbSNP
rs1048485593	965	dbSNP
rs987300457	966	dbSNP
rs888514452	970	dbSNP
rs1462065265	973	dbSNP
rs373541409	982	dbSNP
rs1039887040	983	dbSNP
rs1422832250	985	dbSNP
rs901464757	986	dbSNP
rs998803818	993	dbSNP
rs1030673743	994	dbSNP
rs1191802401	999	dbSNP
rs1481660574	1001	dbSNP
rs879157741	1004	dbSNP
rs1263714511	1006	dbSNP
rs556041798	1007	dbSNP
rs892095957	1011	dbSNP
rs1382290252	1018	dbSNP
rs1350196381	1020	dbSNP
rs34478611	1028	dbSNP
rs1393608144	1037	dbSNP
rs1374912041	1040	dbSNP
rs1291269272	1046	dbSNP
rs990532049	1050	dbSNP
rs1394758529	1051	dbSNP
rs1383087786	1056	dbSNP
rs534868329	1065	dbSNP
rs969094600	1070	dbSNP
rs1159782403	1073	dbSNP
rs750725607	1079	dbSNP
rs557974712	1084	dbSNP
rs766900062	1088	dbSNP
rs751932868	1097	dbSNP
rs368712632	1098	dbSNP
rs1333041275	1099	dbSNP
rs1265414744	1101	dbSNP
rs78396868	1103	dbSNP
rs753290671	1109	dbSNP
rs563090444	1110	dbSNP
rs778270871	1115	dbSNP
rs371826557	1116	dbSNP
rs1261634129	1118	dbSNP
rs745565120	1119	dbSNP
rs746066314	1124	dbSNP
rs771677929	1132	dbSNP
rs1416135154	1133	dbSNP
rs375137456	1134	dbSNP
rs1163729040	1136	dbSNP
rs573600564	1139	dbSNP
rs1401974682	1140	dbSNP
rs1315528428	1143	dbSNP
rs1298644533	1150	dbSNP
rs768597316	1153	dbSNP
rs776567784	1162	dbSNP
rs1371019422	1167	dbSNP
rs369618835	1168	dbSNP
rs761654162	1173	dbSNP
rs1232953353	1175	dbSNP
rs1280383917	1178	dbSNP
rs1353033436	1179	dbSNP
rs189235807	1182	dbSNP
rs559580726	1186	dbSNP
rs528421992	1187	dbSNP
rs891137146	1192	dbSNP
rs75140576	1195	dbSNP
rs766659811	1196	dbSNP
rs1255903191	1199	dbSNP
rs751984313	1200	dbSNP
rs1485560520	1202	dbSNP
rs1183293169	1203	dbSNP
rs759912519	1208	dbSNP
rs1470928663	1215	dbSNP
rs1156364905	1216	dbSNP
rs767766047	1217	dbSNP
rs201279713	1220	dbSNP
rs756553841	1221	dbSNP
rs1435343165	1225	dbSNP
rs1207257370	1226	dbSNP
rs769788892	1232	dbSNP
rs1015722298	1236	dbSNP
rs1413945572	1238	dbSNP
rs778521053	1244	dbSNP
rs749891428	1250	dbSNP
rs192269938	1252	dbSNP
rs1279074948	1253	dbSNP
rs1348653266	1255	dbSNP
rs779627714	1256	dbSNP
rs1278846887	1259	dbSNP
rs1347715308	1261	dbSNP
rs1206337013	1262	dbSNP
rs1275540499	1264	dbSNP
rs1304927436	1272	dbSNP
rs746815094	1276	dbSNP
rs369014044	1281	dbSNP
rs1231862207	1289	dbSNP
rs780837808	1290	dbSNP
rs1194918870	1293	dbSNP
rs1393208869	1295	dbSNP
rs748166122	1300	dbSNP
rs910002554	1301	dbSNP
rs202173848	1306	dbSNP
rs796345805	1310	dbSNP
rs1383688560	1314	dbSNP
rs762805315	1334	dbSNP
rs942758964	1335	dbSNP
rs1435210142	1339	dbSNP
rs1027228958	1353	dbSNP
rs1166791678	1367	dbSNP
rs565085901	1368	dbSNP
rs533421481	1369	dbSNP
rs1039876217	1372	dbSNP
rs1373846533	1377	dbSNP
rs991498092	1380	dbSNP
rs901302921	1382	dbSNP
rs1422439523	1384	dbSNP
rs917553751	1389	dbSNP
rs934272613	1390	dbSNP
rs1281888534	1412	dbSNP
rs1202398113	1425	dbSNP
rs1338406495	1426	dbSNP
rs754476388	1428	dbSNP
rs977859523	1433	dbSNP
rs1053090057	1443	dbSNP
rs1460752143	1448	dbSNP
rs1229112244	1477	dbSNP
rs923730593	1477	dbSNP
rs1292428101	1478	dbSNP
rs936489861	1481	dbSNP
rs1402379209	1482	dbSNP
rs550272982	1485	dbSNP
rs1409467591	1486	dbSNP
rs1397218737	1488	dbSNP
rs1169900214	1489	dbSNP
rs1456537148	1507	dbSNP
rs768578687	1510	dbSNP
rs1417656505	1511	dbSNP
rs1189051597	1512	dbSNP
rs1476510062	1518	dbSNP
rs1250228435	1538	dbSNP
rs1181643009	1540	dbSNP
rs1436757493	1551	dbSNP
rs774190038	1552	dbSNP
rs1197237051	1561	dbSNP
rs1332180104	1562	dbSNP
rs1272391078	1564	dbSNP
rs1391461310	1569	dbSNP
rs569916723	1575	dbSNP
rs904956014	1584	dbSNP
rs1001878224	1588	dbSNP
rs1441341662	1603	dbSNP
rs1333598370	1611	dbSNP
rs535826797	1612	dbSNP
rs1336453464	1629	dbSNP
rs1322045	1630	dbSNP
rs900354778	1634	dbSNP
rs931891481	1637	dbSNP
rs149430479	1642	dbSNP
rs1334557361	1653	dbSNP
rs1463354675	1655	dbSNP
rs1231856487	1664	dbSNP
rs971905780	1667	dbSNP
rs891092422	1669	dbSNP
rs1158523698	1674	dbSNP
rs1470787465	1677	dbSNP
rs1232997302	1678	dbSNP
rs1260472481	1679	dbSNP
rs371740286	1681	dbSNP
rs1466907338	1684	dbSNP
rs1008686092	1690	dbSNP
rs1213856633	1696	dbSNP
rs577701242	1702	dbSNP
rs1026679710	1703	dbSNP
rs1015669849	1705	dbSNP
rs572325005	1707	dbSNP
rs1434378986	1709	dbSNP
rs1370257051	1718	dbSNP
rs1326828399	1724	dbSNP
rs375751449	1740	dbSNP
rs1386976041	1747	dbSNP
rs995606096	1749	dbSNP
rs1195287459	1751	dbSNP
rs1248563914	1752	dbSNP
rs984160017	1753	dbSNP
rs1444232278	1761	dbSNP
rs909845724	1762	dbSNP
rs542656489	1768	dbSNP
rs1452037562	1772	dbSNP
rs1393915522	1774	dbSNP
rs991054453	1776	dbSNP
rs1469516111	1778	dbSNP
rs1240181140	1781	dbSNP
rs773018395	1783	dbSNP
rs1214798208	1788	dbSNP
rs975873402	1789	dbSNP
rs1447569226	1791	dbSNP
rs144815132	1808	dbSNP
rs41277067	1812	dbSNP
rs140201977	1821	dbSNP
rs573687239	1822	dbSNP
rs145518140	1824	dbSNP
rs1270041880	1825	dbSNP
rs183639660	1826	dbSNP
rs921728590	1831	dbSNP
rs1313046752	1859	dbSNP
rs375766711	1861	dbSNP
rs573136506	1870	dbSNP
rs904841509	1877	dbSNP
rs113248660	1878	dbSNP
rs1173679151	1890	dbSNP
rs1455358625	1893	dbSNP
rs1280552503	1894	dbSNP
rs147306576	1915	dbSNP
rs896224110	1921	dbSNP
rs1475619275	1924	dbSNP
rs73438785	1927	dbSNP
rs1037007623	1940	dbSNP
rs1026145722	1944	dbSNP
rs186913613	1947	dbSNP
rs367721053	1948	dbSNP
rs534147941	1949	dbSNP
rs1215344807	1956	dbSNP
rs1257073572	1961	dbSNP
rs1016959344	1973	dbSNP
rs1291795252	1974	dbSNP
rs1414759418	1975	dbSNP
rs563781768	1988	dbSNP
rs1048519705	1994	dbSNP
rs758884950	1997	dbSNP
rs200508663	2008	dbSNP
rs895308956	2009	dbSNP
rs1263632060	2014	dbSNP
rs1428929097	2017	dbSNP
rs1169595924	2029	dbSNP
rs1185532088	2030	dbSNP
rs1012867780	2034	dbSNP
rs191756424	2038	dbSNP
rs553035986	2052	dbSNP
rs75755938	2066	dbSNP
rs565745233	2075	dbSNP
rs528713172	2078	dbSNP
rs1173788099	2079	dbSNP
rs1205548849	2087	dbSNP
rs1309450479	2099	dbSNP
rs999745644	2102	dbSNP
rs184119315	2103	dbSNP
rs1359128639	2112	dbSNP
rs1290300971	2115	dbSNP
rs914040424	2122	dbSNP
rs946984428	2131	dbSNP
rs1370564852	2132	dbSNP
rs989155440	2133	dbSNP
rs1043935102	2136	dbSNP
rs1333400615	2140	dbSNP
rs1402011090	2145	dbSNP
rs926861549	2156	dbSNP
rs752014564	2164	dbSNP
rs1235097861	2167	dbSNP
rs757731792	2170	dbSNP
rs1056124955	2175	dbSNP
rs1167044830	2187	dbSNP
rs921709531	2189	dbSNP
rs896265460	2190	dbSNP
rs1279770254	2192	dbSNP
rs571469882	2200	dbSNP
rs1251386452	2205	dbSNP
rs746094367	2206	dbSNP
rs1047602055	2213	dbSNP
rs887581242	2218	dbSNP
rs1469211411	2219	dbSNP
rs189907908	2228	dbSNP
rs1017553768	2231	dbSNP
rs1316843277	2232	dbSNP
rs1305748943	2234	dbSNP
rs1223870831	2236	dbSNP
rs1378391336	2237	dbSNP
rs964608119	2247	dbSNP
rs1439647467	2261	dbSNP
rs997288054	2263	dbSNP
rs1395012019	2273	dbSNP
rs1029659887	2278	dbSNP
rs1451625810	2279	dbSNP
rs1363144572	2284	dbSNP
rs557298479	2289	dbSNP
rs866972297	2297	dbSNP
rs567350410	2298	dbSNP
rs1441625011	2303	dbSNP
rs1455574436	2304	dbSNP
rs535976105	2309	dbSNP
rs988216289	2313	dbSNP
rs914092895	2322	dbSNP
rs1193684990	2323	dbSNP
rs1255362805	2327	dbSNP
rs1393917288	2335	dbSNP
rs1485715679	2354	dbSNP
rs931337907	2362	dbSNP
rs968213681	2365	dbSNP
rs979557821	2366	dbSNP
rs1218512680	2369	dbSNP
rs926912241	2370	dbSNP
rs938275497	2382	dbSNP
rs1300601760	2384	dbSNP
rs151246929	2385	dbSNP
rs367891384	2386	dbSNP
rs1046971585	2387	dbSNP
rs906718578	2390	dbSNP
rs1442338271	2395	dbSNP
rs1421383714	2400	dbSNP
rs545289970	2402	dbSNP
rs1303352311	2405	dbSNP
rs1373758332	2408	dbSNP
rs1368813358	2412	dbSNP
rs1173088614	2414	dbSNP
rs929059584	2416	dbSNP
rs558879389	2417	dbSNP
rs140420064	2422	dbSNP
rs887507416	2423	dbSNP
rs867065126	2425	dbSNP
rs1428326749	2426	dbSNP
rs1214786486	2432	dbSNP
rs182189386	2445	dbSNP
rs1484959872	2447	dbSNP
rs1277656202	2450	dbSNP
rs1010553291	2451	dbSNP
rs1347898732	2458	dbSNP
rs1257399159	2460	dbSNP
rs1224735822	2473	dbSNP
rs768630066	2476	dbSNP
rs900456437	2479	dbSNP
rs1353475223	2480	dbSNP
rs774302594	2505	dbSNP
rs1312139938	2508	dbSNP
rs1435428195	2511	dbSNP
rs953222224	2523	dbSNP
rs1252315757	2529	dbSNP
rs372103121	2532	dbSNP
rs1019154579	2536	dbSNP
rs1030091236	2537	dbSNP
rs1418199458	2547	dbSNP
rs529345932	2548	dbSNP
rs1448379360	2551	dbSNP
rs961881607	2551	dbSNP
rs1157337099	2557	dbSNP
rs542755234	2563	dbSNP
rs185522281	2566	dbSNP
rs891105722	2572	dbSNP
rs971967470	2578	dbSNP
rs1189186177	2584	dbSNP
rs1462312944	2592	dbSNP
rs572258471	2602	dbSNP
rs1009508130	2604	dbSNP
rs761689919	2614	dbSNP
rs372395954	2615	dbSNP
rs968097641	2619	dbSNP
rs528482315	2620	dbSNP
rs573081194	2622	dbSNP
rs551395538	2623	dbSNP
rs1444458161	2632	dbSNP
rs979610167	2632	dbSNP
rs1033771249	2637	dbSNP
rs959899281	2638	dbSNP
rs571586498	2639	dbSNP
rs1415271441	2652	dbSNP
rs916598114	2659	dbSNP
rs1372841137	2661	dbSNP
rs1326903032	2662	dbSNP
rs1391107632	2663	dbSNP
rs992393142	2663	dbSNP
rs1397465479	2666	dbSNP
rs948111149	2670	dbSNP
rs1046475326	2671	dbSNP
rs917592011	2672	dbSNP
rs935533315	2673	dbSNP
rs190674805	2678	dbSNP
rs929010794	2688	dbSNP
rs1369735394	2690	dbSNP
rs1179036899	2696	dbSNP
rs1436668309	2704	dbSNP
rs1233683014	2705	dbSNP
rs540972153	2719	dbSNP
rs567767931	2720	dbSNP
rs908993939	2728	dbSNP
rs180683602	2734	dbSNP
rs1449853155	2739	dbSNP
rs894091409	2744	dbSNP
rs553120098	2745	dbSNP
rs1232995197	2750	dbSNP
rs1480045015	2754	dbSNP
rs149985201	2755	dbSNP
rs760309589	2757	dbSNP
rs1029055294	2760	dbSNP
rs185397831	2763	dbSNP
rs1336354329	2770	dbSNP
rs1009029577	2773	dbSNP
rs1438917599	2779	dbSNP
rs900306748	2784	dbSNP
rs1018730458	2785	dbSNP
rs1326955417	2797	dbSNP
rs1475700928	2803	dbSNP
rs1406404102	2805	dbSNP
rs558634459	2824	dbSNP
rs1469213495	2827	dbSNP
rs1416308419	2830	dbSNP
rs1051711730	2833	dbSNP
rs575487228	2838	dbSNP
rs537758761	2839	dbSNP
rs554699825	2844	dbSNP
rs1252218185	2848	dbSNP
rs891696074	2850	dbSNP
rs1453056363	2851	dbSNP
rs564601624	2852	dbSNP
rs1009557425	2853	dbSNP
rs1354529057	2859	dbSNP
rs1356419316	2860	dbSNP
rs1232416241	2863	dbSNP
rs1370519102	2876	dbSNP
rs577283449	2883	dbSNP
rs1020909670	2884	dbSNP
rs1343766474	2889	dbSNP
rs903951364	2891	dbSNP
rs1292502335	2892	dbSNP
rs867174406	2895	dbSNP
rs991439080	2900	dbSNP
rs916527019	2910	dbSNP
rs1216218859	2922	dbSNP
rs948086053	2923	dbSNP
rs1212954227	2928	dbSNP
rs542674449	2937	dbSNP
rs982595790	2944	dbSNP
rs1240092563	2946	dbSNP
rs1273659152	2952	dbSNP
rs1192442328	2953	dbSNP
rs1488556095	2968	dbSNP
rs1034276190	2969	dbSNP
rs1208797731	2973	dbSNP
rs959543022	2975	dbSNP
rs1052525965	2977	dbSNP
rs1221108613	2978	dbSNP
rs1360378983	2985	dbSNP
rs1269947822	2992	dbSNP
rs1259172388	2997	dbSNP
rs145597896	3009	dbSNP
rs1342927555	3011	dbSNP
rs1025254102	3014	dbSNP
rs1432330130	3025	dbSNP
rs776628399	3031	dbSNP
rs1374278832	3036	dbSNP
rs1176359227	3044	dbSNP
rs1415798741	3048	dbSNP
rs1187646979	3049	dbSNP
rs1167100002	3065	dbSNP
rs1265260899	3070	dbSNP
rs753333732	3079	dbSNP
rs1476609576	3080	dbSNP
rs73438788	3082	dbSNP
rs1212566591	3085	dbSNP
rs1305980272	3087	dbSNP
rs1272817461	3090	dbSNP
rs908838073	3095	dbSNP
rs963129626	3101	dbSNP
rs974468667	3104	dbSNP
rs921660374	3107	dbSNP
rs758890662	3130	dbSNP
rs1377873333	3141	dbSNP
rs1408276461	3143	dbSNP
rs1449857907	3145	dbSNP
rs1352384920	3152	dbSNP
rs1019093466	3158	dbSNP
rs933199457	3173	dbSNP
rs1465948650	3175	dbSNP
rs1425445278	3176	dbSNP
rs1175673946	3177	dbSNP
rs190106066	3179	dbSNP
rs374707967	3184	dbSNP
rs913188899	3185	dbSNP
rs945928981	3187	dbSNP
rs1414714139	3190	dbSNP
rs1183661218	3194	dbSNP
rs764803912	3202	dbSNP
rs1434381378	3203	dbSNP
rs1232528555	3209	dbSNP
rs1311327279	3210	dbSNP
rs1199460428	3211	dbSNP
rs1461423370	3213	dbSNP
rs1459385028	3214	dbSNP
rs1042379831	3215	dbSNP
rs1271632226	3219	dbSNP
rs1338435832	3222	dbSNP
rs897605546	3225	dbSNP
rs993258952	3226	dbSNP
rs765697758	3234	dbSNP
rs951862031	3240	dbSNP
rs1270628612	3261	dbSNP
rs1013212592	3262	dbSNP
rs181201521	3285	dbSNP
rs969789771	3287	dbSNP
rs531189555	3293	dbSNP
rs1323641312	3297	dbSNP
rs140431969	3298	dbSNP
rs80126846	3300	dbSNP
rs781696131	3301	dbSNP
rs1417440453	3310	dbSNP
rs1013786114	3311	dbSNP
rs368765968	3314	dbSNP
rs1209653495	3317	dbSNP
rs988189833	3318	dbSNP
rs1251590323	3320	dbSNP
rs1449036565	3321	dbSNP
rs1213443731	3323	dbSNP
rs750739479	3341	dbSNP
rs946940387	3347	dbSNP
rs1214221813	3355	dbSNP
rs950944877	3356	dbSNP
rs1307860470	3357	dbSNP
rs1240510224	3369	dbSNP
rs1378638405	3371	dbSNP
rs1300737950	3374	dbSNP
rs1386016587	3375	dbSNP
rs1367994954	3377	dbSNP
rs1448258832	3384	dbSNP
rs1451508685	3386	dbSNP
rs1005102425	3396	dbSNP
rs1015957586	3399	dbSNP
rs1395725964	3402	dbSNP
rs1421815531	3404	dbSNP
rs963066196	3404	dbSNP
rs1393513992	3409	dbSNP
rs974803001	3410	dbSNP
rs944360012	3411	dbSNP
rs1434147783	3412	dbSNP
rs1040032643	3429	dbSNP
rs1171948781	3430	dbSNP
rs185804580	3440	dbSNP
rs547246666	3441	dbSNP
rs1185328847	3446	dbSNP
rs1485825184	3452	dbSNP
rs780300789	3466	dbSNP
rs749367975	3468	dbSNP
rs1216727646	3471	dbSNP
rs1277790740	3480	dbSNP
rs1355147041	3480	dbSNP
rs1402228497	3483	dbSNP
rs145431190	3495	dbSNP
rs538781864	3502	dbSNP
rs1303093486	3503	dbSNP
rs1380521063	3504	dbSNP
rs1339737117	3505	dbSNP
rs1048850564	3509	dbSNP
rs191559839	3512	dbSNP
rs1012789582	3513	dbSNP
rs1466718925	3524	dbSNP
rs1432857045	3539	dbSNP
rs1168761516	3542	dbSNP
rs7045924	3562	dbSNP
rs538113963	3566	dbSNP
rs1196424270	3567	dbSNP
rs1232944155	3568	dbSNP
rs1042929260	3569	dbSNP
rs1488998750	3571	dbSNP
rs41277069	3574	dbSNP
rs1199559615	3578	dbSNP
rs1345272963	3580	dbSNP
rs1003223395	3583	dbSNP
rs375198003	3588	dbSNP
rs1317000369	3593	dbSNP
rs956715404	3594	dbSNP
rs1333588718	3602	dbSNP
rs1055527626	3610	dbSNP
rs1404637520	3613	dbSNP
rs988176949	3615	dbSNP
rs895269395	3618	dbSNP
rs1424732034	3619	dbSNP
rs1216047752	3622	dbSNP
rs1173518140	3624	dbSNP
rs1254195404	3625	dbSNP
rs533715623	3631	dbSNP
rs553595633	3633	dbSNP
rs1046564839	3636	dbSNP
rs1186204813	3642	dbSNP
rs1442429639	3645	dbSNP
rs1257842227	3652	dbSNP
rs886576968	3654	dbSNP
rs572990752	3655	dbSNP
rs1332573596	3656	dbSNP
rs1283468268	3665	dbSNP
rs1016557092	3669	dbSNP
rs545103556	3673	dbSNP
rs963616448	3685	dbSNP
rs1446301914	3687	dbSNP
rs1406925122	3693	dbSNP
rs1455463609	3699	dbSNP
rs565256710	3703	dbSNP
rs1460387132	3706	dbSNP
rs1390658554	3707	dbSNP
rs575565873	3711	dbSNP
rs1164275712	3714	dbSNP
rs1472858927	3714	dbSNP
rs995897894	3717	dbSNP
rs1029037402	3720	dbSNP
rs928988136	3721	dbSNP
rs1048837696	3727	dbSNP
rs887556371	3729	dbSNP
rs1439506763	3736	dbSNP
rs772935869	3738	dbSNP
rs1337130912	3742	dbSNP
rs1239271001	3744	dbSNP
rs1278618375	3745	dbSNP
rs1289103407	3751	dbSNP
rs1210314118	3755	dbSNP
rs1358627056	3762	dbSNP
rs1044216130	3765	dbSNP
rs1239776108	3771	dbSNP
rs907034849	3776	dbSNP
rs138065773	3779	dbSNP
rs74709717	3780	dbSNP
rs1330843941	3781	dbSNP
rs1324807343	3788	dbSNP
rs530474196	3789	dbSNP
rs967206857	3803	dbSNP
rs183815092	3809	dbSNP
rs1418501685	3811	dbSNP
rs770525753	3811	dbSNP
rs925905828	3818	dbSNP
rs776381210	3819	dbSNP
rs937251193	3823	dbSNP
rs1009547477	3837	dbSNP
rs1022324270	3838	dbSNP
rs375538157	3842	dbSNP
rs1181298162	3848	dbSNP
rs759219440	3849	dbSNP
rs1471448402	3858	dbSNP
rs1166906875	3868	dbSNP
rs1418458659	3877	dbSNP
rs916533379	3881	dbSNP
rs1457381993	3883	dbSNP
rs949508221	3888	dbSNP
rs1288464585	3891	dbSNP
rs1217639545	3892	dbSNP
rs780721791	3894	dbSNP
rs1161428140	3898	dbSNP
rs1344808635	3902	dbSNP
rs986637350	3903	dbSNP
rs1439293404	3913	dbSNP
rs1325217009	3917	dbSNP
rs1017732085	3922	dbSNP
rs1398883780	3928	dbSNP
rs140896509	3939	dbSNP
rs1160140847	3971	dbSNP
rs1424288315	3974	dbSNP
rs886511770	3975	dbSNP
rs1172930544	3979	dbSNP
rs1478852676	3982	dbSNP
rs976324600	3983	dbSNP
rs940876171	3996	dbSNP
rs919545493	4001	dbSNP
rs775076321	4002	dbSNP
rs1391479772	4007	dbSNP
rs928935896	4014	dbSNP
rs1442055076	4015	dbSNP
rs1327690967	4016	dbSNP
rs1348310998	4017	dbSNP
rs1037873908	4018	dbSNP
rs899418164	4034	dbSNP
rs386734451	4035	dbSNP
rs7046833	4036	dbSNP
rs7046503	4037	dbSNP
rs1340644697	4038	dbSNP
rs369523283	4043	dbSNP
rs1243202688	4054	dbSNP
rs1008544405	4058	dbSNP
rs1445437527	4068	dbSNP
rs1358229319	4070	dbSNP
rs1334322367	4073	dbSNP
rs1415988401	4074	dbSNP
rs907030310	4080	dbSNP
rs1253617920	4082	dbSNP
rs1020020241	4085	dbSNP
rs756029466	4086	dbSNP
rs1425953418	4088	dbSNP
rs1180208585	4089	dbSNP
rs1472471438	4091	dbSNP
rs1212449659	4094	dbSNP
rs1195304443	4105	dbSNP
rs967093460	4107	dbSNP
rs537424763	4128	dbSNP
rs1189764048	4131	dbSNP
rs1022270580	4132	dbSNP
rs1377754491	4133	dbSNP
rs1032765538	4141	dbSNP
rs1454224745	4141	dbSNP
rs113772207	4142	dbSNP
rs1330420253	4144	dbSNP
rs991784339	4146	dbSNP
rs541695277	4149	dbSNP
rs1374732536	4150	dbSNP
rs568261021	4153	dbSNP
rs982102734	4157	dbSNP
rs1026554309	4159	dbSNP
rs1438066202	4160	dbSNP
rs1238019175	4161	dbSNP
rs1179672765	4166	dbSNP
rs908000734	4170	dbSNP
rs985044414	4173	dbSNP
rs1221409081	4181	dbSNP
rs533874232	4189	dbSNP
rs561847318	4196	dbSNP
rs1951432	4205	dbSNP
rs1394666582	4208	dbSNP
rs932271374	4209	dbSNP
rs1051141275	4212	dbSNP
rs1457318957	4218	dbSNP
rs948425450	4218	dbSNP
rs890699431	4220	dbSNP
rs1009013272	4221	dbSNP
rs1379919537	4223	dbSNP
rs1417882033	4223	dbSNP
rs1159429448	4224	dbSNP
rs1265675727	4229	dbSNP
rs538841668	4229	dbSNP
rs902940826	4230	dbSNP
rs1295551152	4231	dbSNP
rs1246843131	4235	dbSNP
rs1350186552	4235	dbSNP
rs1350812009	4236	dbSNP
rs999866387	4236	dbSNP
rs1284894902	4238	dbSNP
rs1211810089	4239	dbSNP
rs1032818013	4251	dbSNP
rs73438795	4253	dbSNP
rs1482769380	4254	dbSNP
rs891650040	4256	dbSNP
rs1368237647	4258	dbSNP
rs558768136	4263	dbSNP
rs1359921688	4264	dbSNP
rs1024678093	4266	dbSNP
rs1263743920	4267	dbSNP
rs1376350383	4272	dbSNP
rs1429096389	4277	dbSNP
rs1187348115	4283	dbSNP
rs1175781906	4284	dbSNP
rs375218336	4288	dbSNP
rs1008010278	4290	dbSNP
rs560685763	4290	dbSNP
rs1487051662	4291	dbSNP
rs982114174	4292	dbSNP
rs575721636	4293	dbSNP
rs1486636755	4295	dbSNP
rs901956701	4296	dbSNP
rs544279588	4297	dbSNP
rs554991052	4299	dbSNP
rs1291051585	4301	dbSNP
rs575147838	4304	dbSNP
rs932169436	4306	dbSNP
rs1016967335	4307	dbSNP
rs1050607786	4309	dbSNP
rs1466896862	4315	dbSNP
rs1373220112	4320	dbSNP
rs1169216158	4322	dbSNP
rs1951433	4323	dbSNP
rs1422369454	4325	dbSNP
rs944920726	4330	dbSNP
rs1041369862	4337	dbSNP
rs1429710227	4338	dbSNP
rs959759922	4339	dbSNP
rs902826157	4340	dbSNP
rs1196742333	4342	dbSNP
rs1317208204	4344	dbSNP
rs1278698752	4345	dbSNP
rs560639886	4348	dbSNP
rs13301015	4378	dbSNP
rs999918715	4381	dbSNP
rs1338727448	4396	dbSNP
rs1312339451	4398	dbSNP
rs1396797294	4401	dbSNP
rs532767054	4402	dbSNP
rs1385522405	4404	dbSNP
rs1329714910	4406	dbSNP
rs894219201	4413	dbSNP
rs13301043	4422	dbSNP
rs13301044	4423	dbSNP
rs1013207362	4425	dbSNP
rs1207974484	4431	dbSNP
rs1170111258	4440	dbSNP
rs1463086425	4443	dbSNP
rs546410044	4448	dbSNP
rs1024104919	4452	dbSNP
rs971731196	4457	dbSNP
rs13300903	4463	dbSNP
rs1246130060	4467	dbSNP
rs1186445174	4468	dbSNP
rs1469364507	4469	dbSNP
rs1042973861	4471	dbSNP
rs1193791784	4481	dbSNP
rs911152744	4484	dbSNP
rs943369787	4485	dbSNP
rs754104471	4490	dbSNP
rs1264935194	4492	dbSNP
rs3750437	4492	dbSNP
rs531479525	4498	dbSNP
rs1364691308	4502	dbSNP
rs1307271473	4508	dbSNP
rs1446555553	4511	dbSNP
rs1378050702	4512	dbSNP
rs1331513237	4513	dbSNP
rs779030597	4515	dbSNP
rs13302038	4519	dbSNP
rs554818106	4528	dbSNP
rs1424677637	4532	dbSNP
rs1156416682	4533	dbSNP
rs575960477	4538	dbSNP
rs1441719751	4557	dbSNP
rs1266518864	4562	dbSNP
rs953486044	4564	dbSNP
rs1223330886	4571	dbSNP
rs1293063875	4576	dbSNP
rs41277071	4580	dbSNP
rs1239662103	4581	dbSNP
rs1393316024	4584	dbSNP
rs1006824662	4586	dbSNP
rs41277073	4589	dbSNP
rs970688481	4594	dbSNP
rs944973107	4600	dbSNP
rs12353402	4601	dbSNP
rs1035280997	4605	dbSNP
rs111294412	4611	dbSNP
rs935703479	4620	dbSNP
rs1418712801	4621	dbSNP
rs539224217	4624	dbSNP
rs1054126631	4625	dbSNP
rs192293074	4628	dbSNP
rs745523353	4631	dbSNP
rs913020922	4632	dbSNP
rs1012634793	4656	dbSNP
rs1178518324	4678	dbSNP
rs141129245	4684	dbSNP
rs775198930	4687	dbSNP
rs907014231	4695	dbSNP
rs1286532523	4697	dbSNP
rs1420627612	4700	dbSNP
rs1462462112	4702	dbSNP
rs1344703491	4706	dbSNP
rs942588381	4714	dbSNP
rs1004032780	4716	dbSNP
rs1225856828	4718	dbSNP
rs1346921788	4724	dbSNP
rs1164727135	4727	dbSNP
rs1275744975	4731	dbSNP
rs1398787775	4734	dbSNP
rs1345425897	4736	dbSNP
rs1348146119	4737	dbSNP
rs560299567	4748	dbSNP
rs1298893540	4757	dbSNP
rs150722957	4758	dbSNP
rs1401212299	4760	dbSNP
rs1177111512	4761	dbSNP
rs574906201	4764	dbSNP
rs994877267	4769	dbSNP
rs1350173675	4770	dbSNP
rs923260243	4770	dbSNP
rs1027614669	4771	dbSNP
rs933347561	4776	dbSNP
rs1047825258	4789	dbSNP
rs1475742865	4792	dbSNP
rs1244088353	4793	dbSNP
rs575484134	4795	dbSNP
rs886554285	4800	dbSNP
rs1442255139	4818	dbSNP
rs953592948	4820	dbSNP
rs763505594	4821	dbSNP
rs1361981803	4822	dbSNP
rs1271623978	4823	dbSNP
rs1445321929	4828	dbSNP
rs773801567	4829	dbSNP
rs1286278670	4832	dbSNP
rs540892067	4851	dbSNP
rs1337130398	4860	dbSNP
rs966204850	4865	dbSNP
rs977545551	4875	dbSNP
rs924907144	4884	dbSNP
rs1398028524	4886	dbSNP
rs1228769574	4889	dbSNP
rs1410624268	4895	dbSNP
rs1421713999	4901	dbSNP
rs1289077192	4909	dbSNP
rs936218325	4920	dbSNP
rs1472585196	4930	dbSNP
rs1243915857	4934	dbSNP
rs111386156	4942	dbSNP
rs915549977	4950	dbSNP
rs1258008143	4959	dbSNP
rs1035935966	4960	dbSNP
rs895481352	4973	dbSNP
rs1274499325	4978	dbSNP
rs766703494	4981	dbSNP
rs1206093891	4985	dbSNP
rs1315234405	4992	dbSNP
rs948496041	4996	dbSNP
rs1009879095	5001	dbSNP
rs1442797166	5001	dbSNP
rs1045510520	5007	dbSNP
rs906940686	5015	dbSNP
rs1162784988	5016	dbSNP
rs1404769564	5018	dbSNP
rs968844390	5026	dbSNP
rs978553200	5038	dbSNP
rs1018484400	5044	dbSNP
rs1237918276	5044	dbSNP
rs1475749808	5046	dbSNP
rs1181725299	5049	dbSNP
rs1412267815	5055	dbSNP
rs1245433163	5060	dbSNP
rs963947525	5065	dbSNP
rs1490032873	5069	dbSNP
rs1171291241	5077	dbSNP
rs976664543	5084	dbSNP
rs1351288060	5090	dbSNP
rs1306007287	5094	dbSNP
rs1370159845	5100	dbSNP
rs528017019	5104	dbSNP
rs922537855	5109	dbSNP
rs933295153	5112	dbSNP
rs1291671821	5127	dbSNP
rs1428022338	5136	dbSNP
rs983424990	5137	dbSNP
rs1418089210	5139	dbSNP
rs907896559	5147	dbSNP
rs549432921	5149	dbSNP
rs939870355	5150	dbSNP
rs34672737	5153	dbSNP
rs1376987813	5163	dbSNP
rs1191075942	5168	dbSNP
rs751960587	5170	dbSNP
rs1036862059	5171	dbSNP
rs1487111562	5171	dbSNP
rs1448487307	5183	dbSNP
rs937561949	5197	dbSNP
rs1057294691	5202	dbSNP
rs896098854	5205	dbSNP
rs1299162581	5209	dbSNP
rs1376964384	5219	dbSNP
rs577637742	5229	dbSNP
rs898416367	5230	dbSNP
rs1285252245	5231	dbSNP
rs546077204	5232	dbSNP
rs1398169976	5234	dbSNP
rs1019884028	5235	dbSNP
rs555272428	5240	dbSNP
rs904191334	5244	dbSNP
rs1297748088	5253	dbSNP
rs1176388938	5266	dbSNP
rs1340879058	5266	dbSNP
rs1429448905	5279	dbSNP
rs1481048354	5279	dbSNP
rs35687693	5297	dbSNP
rs1200963379	5298	dbSNP
rs995399058	5299	dbSNP
rs1000318678	5310	dbSNP
rs1260634654	5313	dbSNP
rs79676085	5319	dbSNP
rs1282034822	5324	dbSNP
rs531267214	5325	dbSNP
rs964201381	5326	dbSNP
rs1254018036	5330	dbSNP
rs976610646	5331	dbSNP
rs1007953344	5332	dbSNP
rs531619931	5346	dbSNP
rs1264858104	5349	dbSNP
rs550154941	5355	dbSNP
rs951255555	5362	dbSNP
rs561315017	5368	dbSNP
rs527278394	5369	dbSNP
rs963442983	5369	dbSNP
rs1236216727	5378	dbSNP
rs1470468945	5388	dbSNP
rs973892346	5395	dbSNP
rs547017357	5403	dbSNP
rs1169099946	5405	dbSNP
rs1460068537	5413	dbSNP
rs927421582	5414	dbSNP
rs937495454	5420	dbSNP
rs1182762943	5422	dbSNP
rs1240816370	5422	dbSNP
rs1461574345	5430	dbSNP
rs752432832	5430	dbSNP
rs1196653767	5431	dbSNP
rs1338871907	5441	dbSNP
rs1389581817	5443	dbSNP
rs755250335	5455	dbSNP
rs957631484	5456	dbSNP
rs369993073	5460	dbSNP
rs1314581593	5468	dbSNP
rs1041958761	5471	dbSNP
rs1385406315	5481	dbSNP
rs1468456809	5508	dbSNP
rs571818563	5513	dbSNP
rs1391313961	5538	dbSNP
rs1395211908	5542	dbSNP
rs999889643	5543	dbSNP
rs1168003637	5550	dbSNP
rs1039848105	5553	dbSNP
rs948444696	5554	dbSNP
rs533099820	5556	dbSNP
rs981508422	5563	dbSNP
rs1357329935	5564	dbSNP
rs997955266	5570	dbSNP
rs1029464912	5571	dbSNP
rs374328088	5576	dbSNP
rs569837240	5577	dbSNP
rs1246945325	5579	dbSNP
rs1362120325	5592	dbSNP
rs1036871868	5603	dbSNP
rs1004126201	5607	dbSNP
rs1363748232	5614	dbSNP
rs1331418134	5621	dbSNP
rs1225546531	5629	dbSNP
rs1392652666	5635	dbSNP
rs539127540	5644	dbSNP
rs963688709	5649	dbSNP
rs1424899178	5652	dbSNP
rs1345350166	5653	dbSNP
rs1218982449	5657	dbSNP
rs1276997213	5664	dbSNP
rs931241209	5665	dbSNP
rs537926632	5670	dbSNP
rs540085225	5689	dbSNP
rs1479519956	5693	dbSNP
rs1209846066	5694	dbSNP
rs758532635	5697	dbSNP
rs927296825	5701	dbSNP
rs1223574681	5702	dbSNP
rs368982207	5702	dbSNP
rs543473543	5702	dbSNP
rs796590386	5702	dbSNP
rs10814275	5708	dbSNP
rs946251126	5708	dbSNP
rs992875602	5708	dbSNP

- mBio, 2013

UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.

- Genome research, 2016

DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.