miRTarBase - #MIRT469380


—
pre-miRNA Information
pre-miRNA hsa-mir-4708   
Genomic Coordinates chr14: 65335117 - 65335183
Description Homo sapiens miR-4708 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4708-5p
Sequence 9| AGAGAUGCCGCCUUGCUCCUU |29
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1017378847 9 dbSNP
rs750825813 10 dbSNP
rs1297395738 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol RER1   
Synonyms -
Description retention in endoplasmic reticulum sorting receptor 1
Transcript NM_007033   
Expression
Putative miRNA Targets on RER1
3'UTR of RER1
(miRNA target sites are highlighted)		 
>RER1|NM_007033|3'UTR
   1 AAGCGGGACTGAGGCTGCCTCACGTGTTGCAAGAACAGTTTTGAGCCATTGTTAACAATGCCTTTTTTCTTCACATAAAG
  81 TAGTTGATTACGAGGGAGTCAAATTTTCTTTTTAAAAAGGAGCTTCAATGATTTGTAACTGAAATATCAGGTTCTAGAAG
 161 AAACTGGCGCTTAAACCAAATCGCATGGATTTCTTTTTCAGTGACGTTCAAGTGTTTCTCACGGATGGAATTCTAGTCAG
 241 CTGCAGGCGGGAAGCCAGGCGGGTGGAGCCCATGGGAGCAAGGGCGAGTGGCCGGTCCCCGCTGTGCCAGGTGGGCAGGC
 321 AGGAGCAAGGCCTGCGAGGGAGGAACGGGCCGCTCCCCGCCAGCCGCCTTCCCCAGCAGCCGCAGGTGGTGCCAGCCACT
 401 CCACAGAGCCCGAGGGATGATCTAGCCTGATTCCTGCGTGTCCGAAAGAACTTAACGTTTTAAAGGTGATTGTCAAGTAA
 481 CTGTGTGGGGTTCTAATGCCAGTTTCCTAATTCCATCTCACTGGAGATGTTTAAAGTTGGCCTCTATCCTAATGACTCAA
 561 AACTTGGTTCTTAACTACCATGATTGCTTTTGAGGGCCCGGAATTATAAATATATATTATATTTTAATTGTTTGAGATTA
 641 TTTTGACACATTTCTTTGATACGTAGAGTGTTTTGTTTTTAATTTAAATCTGTCCTCATGCAACCCTCCATGAGGGGCAG
 721 CGAAGCTGGCAGGGAGCAGACTGGCTTTGTAGGTTCAGCACTCGGCCCCCCACTGCGGGAGAGGCGGAACCCACTTGCAT
 801 GTCAGCGTTTTTGATTCGAGAAAAGAAATACTCTCAACGTTTTACCAAGTGATTTTACCTCCACCTTTACTAAAGTCTTT
 881 ACCTAAAACATGGCAGTCGCTGGACACAGGAAAGCCCACCTTTTGTTTGGCCTTTTCGAAAGGTGACCCATATTGCACAG
 961 CAGAACATCACAGCTGTGGTCCCAGATGAGACACTGACATGCGAGTGAAGGCCTCTCCTCCTGGGCCCCGGGCTGCGCAG
1041 GCTCCTCACTCTGGGCGGTGTTTCCTGTCTCAGAATTGACACGGTGAATGCTTAGTGTCTGGATTTTCTTGTACCAGTGT
1121 TTACATATCTGACATCGAGCTCCTCTAAGAGGCCACGTTCAAGCTTGTGTGTCCCTGACCCAAGATAGCCAGTGCTGCTC
1201 CCAGGTGGTACTTCTGGTACCGTGTTGAGACACTTGGGATTCTCAGACTGTGGACAGGAGTGTTTGTCATTTTTCATACT
1281 GTTTTCTTAATAAGCGCTCAGGCCTAAGGTGTGACAGGAAGTCGCACGCGCTTGGCCAGAGCACAGTGAAGCAAAGGACT
1361 GGGTGCTGATGGATGGAGCCACGGCGGCATCTGCCCACCCGGCCGCAGCCCCCAGTGCCTCTCCTGGTGGTCCTCCCAGT
1441 CTAGAGGGTCACGGCCCCCCCGCCCTCCTCCGTCTCTGGCAAGCTGACCTTGACTAACCCAGGAATACAGGGTCATCCTC
1521 ATTCCTAAGTAAGTCAAACAGCAAGACATGGTTTGCGCGGGTCTTTGCCGGAAGCCGGTCCTGCTGGCCAGGTGTTTTAC
1601 GTCAGCAGGGAAATGTGGCACACGCCCTCGAGGCATTTTAACACTGCGCTTCAGGAAATCTCAAGTTCCATCTTGTGTTA
1681 GTAACGTACCCACATTTTGCTGGAGTTAGTTTATTAAAGATGCCTACGGTGAACTCTCTGGCGCAGGTTAAATGCAGTTT
1761 TGAAAACCTGGAAACATCAAATGGAGGCGGGAAATAGGCTGGGGCCGAGCTGAGGGGCTGAACACAGCAGTGACCGTGGG
1841 TCAGCAGGTCGCCTGCCCAGCAGGCCCCCCAGGAGAGGGCTCGGGCGCCCCTGGCAGCCCCCATACCCCCAGGACCTGGC
1921 TCGTGAGTGCGTCTGGGTCAGGAAGAGACCTCTCTGTGCGTCTCAGGCTGAGATGCAGATTTCTGTTTTCTAAAACTGGA
2001 AGCGACCTTGACGTGTATTGAAGGTGTGTGTGCCAAATGCTTCCGACGGAGGTGCTGGCCTTGGTTGGTTTCTCTCTGCC
2081 CCGTGTGGTCATCAAGTCCTGGGGGATGTGCTCTGCCCAGCCGCCCTCGGGGAGAGCAGCGCCGCCTCCCATGGGGCCGT
2161 GGGGCTGCTGTTCTCACTGCACTGGCTGAAGCAACCCGCCAGCCTCCGTGCCCCACCCCACCCAGCACGCACTCATTCAG
2241 TCCATTGCCTTAACACAAGCCTGATGGGGCTGTTTTCTCACAATATAAACGAATAAAGTGTCTTCTGGCCTACTTCTGAA
2321 AAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uuCCUC-GUUCCGCCGUAGAga 5'
            |||| || ||||||||||  
Target 5' atGGAGCCACGGCGGCATCTgc 3'
 1373 - 1394 159.00 -25.40
2 
miRNA  3' uuccucguuccgcCGUAGAGa 5'
                       ||:|||| 
Target 5' gagacctctctgtGCGTCTCa 3'
 1945 - 1965 124.00 -10.70
3 
miRNA  3' uucCUCGUUCCGCCGUAGAGa 5'
             |||::|   ||| |||| 
Target 5' tgcGAGTGA--AGGCCTCTCc 3'
 1000 - 1018 122.00 -13.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
876385 1692 ClinVar
876386 1738 ClinVar
296252 1789 ClinVar
296253 1805 ClinVar
296254 1808 ClinVar
874434 1819 ClinVar
296255 1845 ClinVar
296256 1861 ClinVar
296257 1898 ClinVar
296258 1911 ClinVar
296259 1955 ClinVar
875341 1957 ClinVar
875342 1967 ClinVar
875343 2000 ClinVar
296260 2016 ClinVar
875344 2048 ClinVar
296261 2049 ClinVar
296262 2144 ClinVar
875345 2198 ClinVar
296263 2223 ClinVar
296264 2233 ClinVar
875398 2242 ClinVar
296265 2291 ClinVar
COSN30501142 18 COSMIC
COSN31517985 24 COSMIC
COSN30108687 62 COSMIC
COSN31524095 85 COSMIC
COSN31784664 93 COSMIC
COSN30140929 147 COSMIC
COSN23761038 210 COSMIC
COSN31562785 250 COSMIC
COSN8448411 349 COSMIC
COSN32119872 413 COSMIC
COSN22038917 421 COSMIC
COSN31487956 444 COSMIC
COSN31571810 445 COSMIC
COSN26739501 542 COSMIC
COSN31519671 620 COSMIC
COSN7208458 695 COSMIC
COSN26744962 704 COSMIC
COSN6027171 935 COSMIC
COSN20094176 1033 COSMIC
COSN17966249 1114 COSMIC
COSN17872503 1297 COSMIC
COSN28087002 1319 COSMIC
COSN1099883 1367 COSMIC
COSN6447757 1407 COSMIC
COSN16077018 1452 COSMIC
COSN31576858 1627 COSMIC
COSN30161046 1739 COSMIC
COSN15758115 1753 COSMIC
COSN31542000 1865 COSMIC
COSN31488701 1883 COSMIC
COSN26548119 1919 COSMIC
COSN29590311 2093 COSMIC
COSN7208503 2139 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs77184759 5 dbSNP
rs377584177 6 dbSNP
rs1488369352 8 dbSNP
rs755889209 12 dbSNP
rs760679126 13 dbSNP
rs779740234 18 dbSNP
rs1409931739 19 dbSNP
rs1287136847 20 dbSNP
rs748938589 24 dbSNP
rs768487998 25 dbSNP
rs1421099355 27 dbSNP
rs774327280 30 dbSNP
rs747090636 31 dbSNP
rs1457219637 33 dbSNP
rs566272500 34 dbSNP
rs370526635 37 dbSNP
rs765596797 38 dbSNP
rs772904445 38 dbSNP
rs775723930 39 dbSNP
rs1330089762 46 dbSNP
rs375684587 49 dbSNP
rs1306177224 50 dbSNP
rs1249706724 56 dbSNP
rs763461549 60 dbSNP
rs1225058632 63 dbSNP
rs764691613 64 dbSNP
rs752151435 68 dbSNP
rs756804483 73 dbSNP
rs767157674 74 dbSNP
rs910866767 75 dbSNP
rs750048307 76 dbSNP
rs538366261 81 dbSNP
rs1236416810 84 dbSNP
rs1170823871 86 dbSNP
rs779837628 90 dbSNP
rs749021161 92 dbSNP
rs377269316 93 dbSNP
rs1306948903 96 dbSNP
rs1393679137 104 dbSNP
rs1422337477 105 dbSNP
rs1334406479 109 dbSNP
rs144802592 109 dbSNP
rs1339471085 112 dbSNP
rs1023362856 114 dbSNP
rs1299506951 115 dbSNP
rs1485579048 124 dbSNP
rs970179405 129 dbSNP
rs981549874 131 dbSNP
rs575423409 140 dbSNP
rs1484278807 145 dbSNP
rs1043200285 148 dbSNP
rs1255760027 152 dbSNP
rs1440891490 154 dbSNP
rs904646369 155 dbSNP
rs1035757237 157 dbSNP
rs76184090 161 dbSNP
rs188820327 165 dbSNP
rs895787133 169 dbSNP
rs1467162572 170 dbSNP
rs1396035293 178 dbSNP
rs909141430 179 dbSNP
rs1013928725 183 dbSNP
rs1365674167 184 dbSNP
rs555336944 184 dbSNP
rs753162415 186 dbSNP
rs560965398 187 dbSNP
rs1156440889 190 dbSNP
rs1234121285 193 dbSNP
rs1344105062 195 dbSNP
rs1255461802 202 dbSNP
rs1321759799 204 dbSNP
rs961589147 206 dbSNP
rs572733043 207 dbSNP
rs994028876 210 dbSNP
rs575166071 215 dbSNP
rs1290592000 220 dbSNP
rs1199035380 221 dbSNP
rs952458666 223 dbSNP
rs45579641 224 dbSNP
rs1160926560 229 dbSNP
rs1440054612 237 dbSNP
rs796746411 241 dbSNP
rs965032474 243 dbSNP
rs1388861051 244 dbSNP
rs148530549 245 dbSNP
rs538017546 249 dbSNP
rs1387276684 250 dbSNP
rs1300750542 251 dbSNP
rs902264089 252 dbSNP
rs1230234913 256 dbSNP
rs41315646 261 dbSNP
rs1282357742 262 dbSNP
rs1033308097 265 dbSNP
rs1267599811 270 dbSNP
rs1489125665 279 dbSNP
rs771499660 280 dbSNP
rs1267302069 284 dbSNP
rs1479185579 286 dbSNP
rs538382959 287 dbSNP
rs1053657055 289 dbSNP
rs41315648 294 dbSNP
rs1012212679 295 dbSNP
rs1458173098 299 dbSNP
rs115090288 301 dbSNP
rs1213606963 302 dbSNP
rs1411768657 306 dbSNP
rs1289044478 307 dbSNP
rs1350173407 307 dbSNP
rs937441745 309 dbSNP
rs1315038598 310 dbSNP
rs1012733695 320 dbSNP
rs1290242144 325 dbSNP
rs1055772372 332 dbSNP
rs1206728173 334 dbSNP
rs1251906911 336 dbSNP
rs1480140810 336 dbSNP
rs1175137580 337 dbSNP
rs1035812641 340 dbSNP
rs1424211033 341 dbSNP
rs895807564 345 dbSNP
rs530649929 347 dbSNP
rs950746970 348 dbSNP
rs777391997 351 dbSNP
rs1036765794 352 dbSNP
rs1380093674 353 dbSNP
rs1012590328 355 dbSNP
rs1228156684 356 dbSNP
rs1160724205 357 dbSNP
rs1016489210 359 dbSNP
rs897093203 360 dbSNP
rs1229774770 362 dbSNP
rs1274481678 364 dbSNP
rs1306421596 365 dbSNP
rs1460917652 366 dbSNP
rs975094639 367 dbSNP
rs1483361372 376 dbSNP
rs921854105 378 dbSNP
rs1241023092 379 dbSNP
rs994061364 380 dbSNP
rs1169146209 382 dbSNP
rs1444229218 383 dbSNP
rs1026833012 389 dbSNP
rs888247730 393 dbSNP
rs1408296738 394 dbSNP
rs1178293689 400 dbSNP
rs1278036073 402 dbSNP
rs1372815338 404 dbSNP
rs543979001 412 dbSNP
rs1018060403 413 dbSNP
rs1332746104 414 dbSNP
rs1297556508 422 dbSNP
rs1360434190 423 dbSNP
rs923694724 427 dbSNP
rs11557746 429 dbSNP
rs1213627805 429 dbSNP
rs965492049 434 dbSNP
rs914751992 439 dbSNP
rs1466112769 443 dbSNP
rs1202805062 444 dbSNP
rs1241491773 452 dbSNP
rs1232641388 453 dbSNP
rs775761138 457 dbSNP
rs1045079363 458 dbSNP
rs1411069485 474 dbSNP
rs1425947631 477 dbSNP
rs906108640 481 dbSNP
rs1002885483 482 dbSNP
rs1391062256 490 dbSNP
rs41315650 494 dbSNP
rs1057117573 508 dbSNP
rs77592022 513 dbSNP
rs1005348420 515 dbSNP
rs1275898916 532 dbSNP
rs1367699107 536 dbSNP
rs1222330576 542 dbSNP
rs978956435 548 dbSNP
rs1234775835 549 dbSNP
rs1209162244 552 dbSNP
rs963568330 556 dbSNP
rs1445267367 557 dbSNP
rs1223696276 561 dbSNP
rs1247149238 567 dbSNP
rs1480170825 568 dbSNP
rs1463891843 571 dbSNP
rs926131510 593 dbSNP
rs1473023965 596 dbSNP
rs1354890827 597 dbSNP
rs763182342 600 dbSNP
rs1383245794 601 dbSNP
rs992065485 604 dbSNP
rs1443272196 605 dbSNP
rs917375935 606 dbSNP
rs1300051473 610 dbSNP
rs1353648100 613 dbSNP
rs954589154 613 dbSNP
rs1352016184 620 dbSNP
rs529930172 620 dbSNP
rs758059092 621 dbSNP
rs950158907 626 dbSNP
rs1278535241 628 dbSNP
rs1337645637 628 dbSNP
rs1229783039 629 dbSNP
rs1213294998 630 dbSNP
rs923578251 637 dbSNP
rs1036382411 648 dbSNP
rs1254066781 649 dbSNP
rs914992616 651 dbSNP
rs989657569 651 dbSNP
rs1206200683 652 dbSNP
rs1254880845 653 dbSNP
rs748769958 654 dbSNP
rs1385196706 656 dbSNP
rs770573398 663 dbSNP
rs1300806253 664 dbSNP
rs927535396 665 dbSNP
rs546451496 668 dbSNP
rs938892716 670 dbSNP
rs1327809197 691 dbSNP
rs1057168518 693 dbSNP
rs886469126 695 dbSNP
rs566350067 697 dbSNP
rs1358726541 700 dbSNP
rs1243667754 705 dbSNP
rs764329125 706 dbSNP
rs929885455 712 dbSNP
rs1258983141 713 dbSNP
rs1038230253 722 dbSNP
rs532109114 723 dbSNP
rs1167246042 725 dbSNP
rs996414102 726 dbSNP
rs1028758700 727 dbSNP
rs564835112 728 dbSNP
rs1171037406 730 dbSNP
rs751570066 739 dbSNP
rs890384461 752 dbSNP
rs888359670 757 dbSNP
rs1030856300 761 dbSNP
rs113686958 764 dbSNP
rs374119507 765 dbSNP
rs1022473556 766 dbSNP
rs989150887 766 dbSNP
rs538085095 768 dbSNP
rs548799121 769 dbSNP
rs969127648 775 dbSNP
rs1249679820 776 dbSNP
rs1357444755 777 dbSNP
rs368306020 778 dbSNP
rs568627959 786 dbSNP
rs534498721 787 dbSNP
rs1340507880 796 dbSNP
rs1190858929 799 dbSNP
rs980697500 800 dbSNP
rs1428414674 801 dbSNP
rs1191933339 806 dbSNP
rs554477386 807 dbSNP
rs1467080385 808 dbSNP
rs865974485 811 dbSNP
rs181572880 818 dbSNP
rs1033265025 819 dbSNP
rs958942107 821 dbSNP
rs993104103 823 dbSNP
rs560687760 831 dbSNP
rs1385664213 835 dbSNP
rs577180277 838 dbSNP
rs940721721 839 dbSNP
rs1332909569 840 dbSNP
rs917380096 843 dbSNP
rs1224154849 846 dbSNP
rs1282909657 848 dbSNP
rs116414456 853 dbSNP
rs556407612 857 dbSNP
rs899263586 859 dbSNP
rs1261677534 860 dbSNP
rs1485862624 866 dbSNP
rs1242589593 871 dbSNP
rs932055109 873 dbSNP
rs1270015632 876 dbSNP
rs779876673 883 dbSNP
rs1476282361 892 dbSNP
rs576476845 895 dbSNP
rs544043472 898 dbSNP
rs370830583 899 dbSNP
rs1049083026 900 dbSNP
rs1364176814 902 dbSNP
rs1452697252 907 dbSNP
rs1030908658 909 dbSNP
rs892351992 910 dbSNP
rs909829375 911 dbSNP
rs775404235 916 dbSNP
rs1394217883 927 dbSNP
rs1010993699 929 dbSNP
rs942593195 931 dbSNP
rs1174484256 933 dbSNP
rs1039558634 938 dbSNP
rs1270371522 939 dbSNP
rs980547078 939 dbSNP
rs760711811 944 dbSNP
rs574248910 948 dbSNP
rs960234385 950 dbSNP
rs1489605368 951 dbSNP
rs1398958079 956 dbSNP
rs1178579524 958 dbSNP
rs754639132 959 dbSNP
rs1250741853 968 dbSNP
rs997953836 970 dbSNP
rs1156642625 977 dbSNP
rs1041822688 984 dbSNP
rs540162023 999 dbSNP
rs1163080054 1000 dbSNP
rs940929108 1002 dbSNP
rs973823772 1003 dbSNP
rs1298995503 1006 dbSNP
rs920634712 1010 dbSNP
rs1433481238 1012 dbSNP
rs560361072 1018 dbSNP
rs1301753670 1024 dbSNP
rs1245903807 1028 dbSNP
rs150521482 1030 dbSNP
rs532046435 1030 dbSNP
rs552129409 1031 dbSNP
rs1205945907 1035 dbSNP
rs562308014 1036 dbSNP
rs911966336 1037 dbSNP
rs1032628473 1038 dbSNP
rs958964630 1039 dbSNP
rs762975023 1040 dbSNP
rs1024482909 1044 dbSNP
rs971930897 1045 dbSNP
rs972255935 1052 dbSNP
rs1252208884 1054 dbSNP
rs1460643668 1057 dbSNP
rs1454507993 1058 dbSNP
rs1383992669 1065 dbSNP
rs1452322074 1068 dbSNP
rs1194511049 1073 dbSNP
rs1313581004 1081 dbSNP
rs1052181784 1083 dbSNP
rs771698037 1084 dbSNP
rs1273093133 1091 dbSNP
rs1158123254 1104 dbSNP
rs892397741 1108 dbSNP
rs777496180 1112 dbSNP
rs1129333 1114 dbSNP
rs1202746249 1117 dbSNP
rs1241240421 1119 dbSNP
rs1476347136 1123 dbSNP
rs1459334882 1126 dbSNP
rs548259957 1129 dbSNP
rs1178889446 1130 dbSNP
rs1044023857 1135 dbSNP
rs904881781 1137 dbSNP
rs568691492 1138 dbSNP
rs1305203231 1140 dbSNP
rs1333670671 1141 dbSNP
rs1237840509 1143 dbSNP
rs1212260642 1146 dbSNP
rs1284833303 1148 dbSNP
rs1323780831 1150 dbSNP
rs984812325 1157 dbSNP
rs1261004735 1158 dbSNP
rs185473832 1161 dbSNP
rs112157120 1166 dbSNP
rs1352200791 1171 dbSNP
rs942647035 1174 dbSNP
rs1484946814 1175 dbSNP
rs72924936 1180 dbSNP
rs1201656141 1185 dbSNP
rs960411014 1186 dbSNP
rs1480231038 1189 dbSNP
rs1014448968 1196 dbSNP
rs1410638761 1199 dbSNP
rs1401581910 1201 dbSNP
rs1318287416 1211 dbSNP
rs1343902188 1220 dbSNP
rs142854762 1222 dbSNP
rs962507976 1223 dbSNP
rs1345813427 1228 dbSNP
rs1222534975 1230 dbSNP
rs1215285650 1233 dbSNP
rs973703399 1234 dbSNP
rs556510984 1235 dbSNP
rs368710052 1240 dbSNP
rs922463906 1247 dbSNP
rs182425795 1257 dbSNP
rs1283532687 1261 dbSNP
rs986058422 1262 dbSNP
rs1041526270 1265 dbSNP
rs1269681905 1269 dbSNP
rs1490190532 1270 dbSNP
rs1197544756 1277 dbSNP
rs1234782003 1278 dbSNP
rs902971702 1279 dbSNP
rs1158334571 1284 dbSNP
rs999884572 1291 dbSNP
rs1054061083 1293 dbSNP
rs548372048 1296 dbSNP
rs944772035 1297 dbSNP
rs1163439517 1304 dbSNP
rs1164705687 1307 dbSNP
rs386627610 1308 dbSNP
rs74049248 1309 dbSNP
rs58886116 1311 dbSNP
rs768805802 1314 dbSNP
rs1337138968 1318 dbSNP
rs946525295 1321 dbSNP
rs1278733748 1323 dbSNP
rs1043688335 1324 dbSNP
rs905100854 1325 dbSNP
rs114238434 1326 dbSNP
rs540025435 1328 dbSNP
rs111500533 1330 dbSNP
rs984846127 1331 dbSNP
rs1015741181 1336 dbSNP
rs910564234 1342 dbSNP
rs965031605 1345 dbSNP
rs1231540832 1346 dbSNP
rs976109602 1354 dbSNP
rs1235031077 1357 dbSNP
rs1249474652 1360 dbSNP
rs1184781541 1361 dbSNP
rs922547049 1363 dbSNP
rs1195444234 1365 dbSNP
rs1423506048 1372 dbSNP
rs1251460254 1375 dbSNP
rs1398266333 1376 dbSNP
rs1410171615 1380 dbSNP
rs933912985 1381 dbSNP
rs977250548 1383 dbSNP
rs1156708471 1384 dbSNP
rs547988419 1386 dbSNP
rs935758864 1387 dbSNP
rs1315675876 1392 dbSNP
rs1381924101 1394 dbSNP
rs1054091709 1398 dbSNP
rs552883480 1401 dbSNP
rs948424021 1402 dbSNP
rs1371716229 1403 dbSNP
rs1045389030 1405 dbSNP
rs1271093357 1406 dbSNP
rs12085089 1407 dbSNP
rs993725330 1409 dbSNP
rs1432457912 1410 dbSNP
rs1374309240 1413 dbSNP
rs1475419616 1416 dbSNP
rs1026498849 1424 dbSNP
rs1166996362 1426 dbSNP
rs1311791253 1427 dbSNP
rs966005772 1428 dbSNP
rs988268856 1430 dbSNP
rs1355540502 1431 dbSNP
rs562505753 1434 dbSNP
rs1293267390 1439 dbSNP
rs1394229729 1442 dbSNP
rs750516730 1444 dbSNP
rs1227824896 1451 dbSNP
rs1327129624 1453 dbSNP
rs1226713966 1455 dbSNP
rs1252828616 1455 dbSNP
rs1325887631 1455 dbSNP
rs531302531 1458 dbSNP
rs913973858 1460 dbSNP
rs1017742143 1461 dbSNP
rs1207415363 1462 dbSNP
rs964819192 1463 dbSNP
rs946606377 1464 dbSNP
rs1191821901 1469 dbSNP
rs976520937 1472 dbSNP
rs760613101 1473 dbSNP
rs1176968294 1474 dbSNP
rs548318428 1475 dbSNP
rs1486006997 1477 dbSNP
rs1365389492 1480 dbSNP
rs1464319084 1485 dbSNP
rs1290580723 1489 dbSNP
rs1030315714 1490 dbSNP
rs955492663 1495 dbSNP
rs1260210488 1501 dbSNP
rs926530244 1503 dbSNP
rs977274066 1504 dbSNP
rs1347682672 1510 dbSNP
rs867387567 1512 dbSNP
rs1282813474 1516 dbSNP
rs561751738 1518 dbSNP
rs1392385522 1519 dbSNP
rs937881970 1526 dbSNP
rs1172614494 1528 dbSNP
rs1261877693 1529 dbSNP
rs185811960 1530 dbSNP
rs1350555977 1532 dbSNP
rs1215347336 1533 dbSNP
rs1388057655 1537 dbSNP
rs753603145 1542 dbSNP
rs1056382049 1543 dbSNP
rs140666446 1550 dbSNP
rs79073409 1551 dbSNP
rs935873907 1557 dbSNP
rs939663753 1558 dbSNP
rs533688981 1559 dbSNP
rs898204055 1560 dbSNP
rs1156703968 1561 dbSNP
rs1367536999 1562 dbSNP
rs189798947 1570 dbSNP
rs569738189 1571 dbSNP
rs1028211478 1574 dbSNP
rs1232388781 1577 dbSNP
rs948479521 1578 dbSNP
rs889380542 1582 dbSNP
rs1335751533 1583 dbSNP
rs1238631130 1584 dbSNP
rs535424233 1585 dbSNP
rs1360998064 1589 dbSNP
rs1212273505 1598 dbSNP
rs906838819 1601 dbSNP
rs1178786471 1602 dbSNP
rs1438777414 1611 dbSNP
rs929553300 1611 dbSNP
rs1176736626 1616 dbSNP
rs1047971273 1617 dbSNP
rs1425438299 1618 dbSNP
rs1162976727 1622 dbSNP
rs888027109 1624 dbSNP
rs1006430876 1625 dbSNP
rs988540107 1626 dbSNP
rs1452904366 1628 dbSNP
rs144627253 1630 dbSNP
rs1246158666 1631 dbSNP
rs1319342016 1634 dbSNP
rs752396864 1644 dbSNP
rs1395254909 1645 dbSNP
rs1251486853 1646 dbSNP
rs1129332 1648 dbSNP
rs997587976 1649 dbSNP
rs926471404 1659 dbSNP
rs1156362740 1661 dbSNP
rs1030753736 1663 dbSNP
rs966641275 1664 dbSNP
rs992114362 1666 dbSNP
rs1411740951 1670 dbSNP
rs1430317534 1678 dbSNP
rs978058819 1684 dbSNP
rs533795387 1686 dbSNP
rs957271960 1690 dbSNP
rs1464426880 1695 dbSNP
rs939708778 1701 dbSNP
rs989965259 1702 dbSNP
rs748760810 1704 dbSNP
rs915721658 1705 dbSNP
rs970224494 1706 dbSNP
rs981181462 1714 dbSNP
rs1301534395 1724 dbSNP
rs931030324 1728 dbSNP
rs928293169 1729 dbSNP
rs770358289 1734 dbSNP
rs1215766052 1735 dbSNP
rs1295911248 1736 dbSNP
rs1316891759 1738 dbSNP
rs1049479889 1743 dbSNP
rs1264761035 1744 dbSNP
rs928995016 1747 dbSNP
rs1047421292 1757 dbSNP
rs777319062 1758 dbSNP
rs1209345866 1771 dbSNP
rs1235629526 1773 dbSNP
rs553925067 1788 dbSNP
rs556816263 1789 dbSNP
rs757934099 1797 dbSNP
rs998010199 1800 dbSNP
rs1051893359 1803 dbSNP
rs886046135 1805 dbSNP
rs1174601675 1807 dbSNP
rs886046136 1808 dbSNP
rs1432336008 1813 dbSNP
rs1288938989 1819 dbSNP
rs902070838 1821 dbSNP
rs1397766798 1826 dbSNP
rs1009572932 1831 dbSNP
rs1324046533 1832 dbSNP
rs902595978 1836 dbSNP
rs546098123 1837 dbSNP
rs1318649158 1843 dbSNP
rs886046137 1845 dbSNP
rs957302255 1849 dbSNP
rs906989044 1850 dbSNP
rs1201901839 1851 dbSNP
rs959226172 1852 dbSNP
rs556147666 1853 dbSNP
rs1011462654 1856 dbSNP
rs1189813083 1857 dbSNP
rs886046138 1861 dbSNP
rs1410891528 1867 dbSNP
rs1023227276 1868 dbSNP
rs1253983383 1871 dbSNP
rs1158513816 1877 dbSNP
rs35859093 1883 dbSNP
rs576138110 1884 dbSNP
rs1304610559 1885 dbSNP
rs180943456 1887 dbSNP
rs561812569 1888 dbSNP
rs950435731 1891 dbSNP
rs1375179436 1898 dbSNP
rs886046139 1898 dbSNP
rs1419082107 1899 dbSNP
rs983142215 1901 dbSNP
rs930977373 1902 dbSNP
rs1224276455 1904 dbSNP
rs1415518478 1906 dbSNP
rs1049508510 1910 dbSNP
rs886046140 1911 dbSNP
rs943548980 1912 dbSNP
rs1451249240 1923 dbSNP
rs778521596 1923 dbSNP
rs779726539 1924 dbSNP
rs1470680860 1928 dbSNP
rs1039246554 1931 dbSNP
rs780436903 1932 dbSNP
rs922173877 1934 dbSNP
rs1437318944 1937 dbSNP
rs3370 1948 dbSNP
rs1164927827 1952 dbSNP
rs1351403106 1953 dbSNP
rs1010262344 1955 dbSNP
rs886046141 1955 dbSNP
rs1438950774 1956 dbSNP
rs41310349 1957 dbSNP
rs77818102 1961 dbSNP
rs77863194 1967 dbSNP
rs1000865154 1970 dbSNP
rs554357307 1982 dbSNP
rs1248349298 1989 dbSNP
rs1284842967 1991 dbSNP
rs902628417 1993 dbSNP
rs142302722 1998 dbSNP
rs150136015 2000 dbSNP
rs893773166 2004 dbSNP
rs1024782724 2005 dbSNP
rs546887000 2013 dbSNP
rs377439419 2014 dbSNP
rs886046142 2016 dbSNP
rs1472154517 2017 dbSNP
rs370826120 2020 dbSNP
rs1231914124 2024 dbSNP
rs1483110160 2025 dbSNP
rs1002739874 2026 dbSNP
rs762000671 2030 dbSNP
rs1330420552 2032 dbSNP
rs772303662 2039 dbSNP
rs1398100437 2041 dbSNP
rs773303566 2045 dbSNP
rs1334663446 2046 dbSNP
rs72924937 2048 dbSNP
rs760677467 2049 dbSNP
rs766283608 2064 dbSNP
rs1040533305 2067 dbSNP
rs753709035 2070 dbSNP
rs1415714807 2071 dbSNP
rs1462880409 2073 dbSNP
rs945561674 2075 dbSNP
rs1407941006 2076 dbSNP
rs974804584 2077 dbSNP
rs879830512 2082 dbSNP
rs759617739 2083 dbSNP
rs1169446882 2084 dbSNP
rs895243371 2088 dbSNP
rs141839636 2089 dbSNP
rs1310004060 2094 dbSNP
rs1353626341 2100 dbSNP
rs1394409962 2102 dbSNP
rs933547504 2109 dbSNP
rs1399631374 2112 dbSNP
rs1276493707 2114 dbSNP
rs1326128881 2119 dbSNP
rs200610722 2123 dbSNP
rs924082874 2124 dbSNP
rs1343488356 2127 dbSNP
rs1285233098 2129 dbSNP
rs935425137 2130 dbSNP
rs879033374 2132 dbSNP
rs1381836745 2138 dbSNP
rs1053758295 2141 dbSNP
rs1192528401 2142 dbSNP
rs893890794 2143 dbSNP
rs886046143 2144 dbSNP
rs948115083 2145 dbSNP
rs994009655 2147 dbSNP
rs1206851270 2151 dbSNP
rs1277648967 2152 dbSNP
rs765098120 2156 dbSNP
rs1027326081 2157 dbSNP
rs529280054 2159 dbSNP
rs548964694 2160 dbSNP
rs565878700 2165 dbSNP
rs1296628427 2168 dbSNP
rs1347598294 2169 dbSNP
rs1387767473 2169 dbSNP
rs1045459421 2171 dbSNP
rs985111070 2178 dbSNP
rs1017867399 2179 dbSNP
rs535130776 2181 dbSNP
rs1239095038 2184 dbSNP
rs976509906 2188 dbSNP
rs1215218702 2189 dbSNP
rs905804660 2196 dbSNP
rs557941413 2198 dbSNP
rs1035537973 2199 dbSNP
rs1419955754 2204 dbSNP
rs1209998021 2208 dbSNP
rs886241541 2209 dbSNP
rs1004714579 2211 dbSNP
rs11544147 2214 dbSNP
rs1180468139 2217 dbSNP
rs868844283 2223 dbSNP
rs879001345 2224 dbSNP
rs760413807 2227 dbSNP
rs963442536 2229 dbSNP
rs974456230 2230 dbSNP
rs886046144 2233 dbSNP
rs866387988 2242 dbSNP
rs1393457844 2243 dbSNP
rs987647966 2245 dbSNP
rs1376775852 2260 dbSNP
rs1238862947 2270 dbSNP
rs897205763 2272 dbSNP
rs1322943312 2273 dbSNP
rs994409991 2275 dbSNP
rs924113843 2276 dbSNP
rs1264455646 2281 dbSNP
rs1366363919 2282 dbSNP
rs1026796888 2283 dbSNP
rs1230164604 2285 dbSNP
rs115735911 2291 dbSNP
rs556526252 2292 dbSNP
rs989600858 2293 dbSNP
rs1200486125 2303 dbSNP
rs915354894 2305 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uuccucguuccgccGUAGAGa 5'
                        |||||| 
Target 5' caguuuccuaauucCAUCUCa 3'
 		8 - 28
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000605895.1 | 3UTR | CUAAUGCCAGUUUCCUAAUUCCAUCUCACUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
94 hsa-miR-4708-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT095681 RBM27 RNA binding motif protein 27 2 4
MIRT104033 USP42 ubiquitin specific peptidase 42 2 6
MIRT114773 CMPK1 cytidine/uridine monophosphate kinase 1 2 2
MIRT246923 CCND1 cyclin D1 2 2
MIRT392569 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT443949 LRIT3 leucine rich repeat, Ig-like and transmembrane domains 3 2 2
MIRT446695 PAPPA pappalysin 1 2 2
MIRT447383 VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 2 2
MIRT449321 FAM120AOS family with sequence similarity 120A opposite strand 2 2
MIRT449717 C1orf61 chromosome 1 open reading frame 61 2 2
MIRT449738 TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 2 2
MIRT450531 PGLS 6-phosphogluconolactonase 2 2
MIRT455650 YARS tyrosyl-tRNA synthetase 2 2
MIRT458036 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT463468 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT466677 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 4
MIRT467789 SLC2A14 solute carrier family 2 member 14 2 2
MIRT468167 SGPL1 sphingosine-1-phosphate lyase 1 2 2
MIRT468652 SECISBP2L SECIS binding protein 2 like 2 6
MIRT469380 RER1 retention in endoplasmic reticulum sorting receptor 1 2 2
MIRT470346 PPP2R5E protein phosphatase 2 regulatory subunit B'epsilon 2 2
MIRT472418 NCKAP1 NCK associated protein 1 2 2
MIRT474612 KLF3 Kruppel like factor 3 2 2
MIRT478703 CSRNP2 cysteine and serine rich nuclear protein 2 2 2
MIRT481008 BBC3 BCL2 binding component 3 2 4
MIRT483098 TFPI tissue factor pathway inhibitor 2 2
MIRT485113 SHISA6 shisa family member 6 2 2
MIRT497533 ZNF607 zinc finger protein 607 2 2
MIRT500644 TUBB2A tubulin beta 2A class IIa 2 6
MIRT500890 STRN striatin 2 4
MIRT501900 MED13 mediator complex subunit 13 2 2
MIRT506646 MAPK1 mitogen-activated protein kinase 1 2 4
MIRT512675 ENO4 enolase family member 4 2 2
MIRT516977 OR7D2 olfactory receptor family 7 subfamily D member 2 2 2
MIRT528754 RPS27 ribosomal protein S27 2 6
MIRT539670 ZBTB44 zinc finger and BTB domain containing 44 2 2
MIRT544129 PPIL1 peptidylprolyl isomerase like 1 2 2
MIRT546382 STOX2 storkhead box 2 2 4
MIRT562143 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT568713 TMEM30B transmembrane protein 30B 2 2
MIRT571029 CENPP centromere protein P 2 2
MIRT572781 ZNF277 zinc finger protein 277 2 2
MIRT573162 SLC30A9 solute carrier family 30 member 9 2 2
MIRT609126 NUDT3 nudix hydrolase 3 2 2
MIRT609284 OAS3 2'-5'-oligoadenylate synthetase 3 2 2
MIRT613430 GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 2 2
MIRT613770 TTC38 tetratricopeptide repeat domain 38 2 2
MIRT616645 LRAT lecithin retinol acyltransferase 2 4
MIRT630892 SLC25A33 solute carrier family 25 member 33 2 2
MIRT636526 FAXC failed axon connections homolog 2 4
MIRT641394 NUBPL nucleotide binding protein like 2 2
MIRT641412 SCN2B sodium voltage-gated channel beta subunit 2 2 2
MIRT642528 CERS4 ceramide synthase 4 2 2
MIRT643186 HYPK huntingtin interacting protein K 2 2
MIRT647800 FRMD8 FERM domain containing 8 2 2
MIRT652150 TRIM71 tripartite motif containing 71 2 2
MIRT652602 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT661606 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT666339 SKAP2 src kinase associated phosphoprotein 2 2 2
MIRT670414 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT671122 ZNF573 zinc finger protein 573 2 2
MIRT671155 ANKRD9 ankyrin repeat domain 9 2 2
MIRT671338 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT671869 ZNF429 zinc finger protein 429 2 2
MIRT671974 IKZF3 IKAROS family zinc finger 3 2 2
MIRT672064 KIAA0930 KIAA0930 2 2
MIRT672654 SLC25A16 solute carrier family 25 member 16 2 4
MIRT672673 GTF2H5 general transcription factor IIH subunit 5 2 2
MIRT672771 UBE2V2 ubiquitin conjugating enzyme E2 V2 2 2
MIRT672929 LRRC2 leucine rich repeat containing 2 2 2
MIRT673159 C1orf50 chromosome 1 open reading frame 50 2 2
MIRT673272 RUNDC1 RUN domain containing 1 2 2
MIRT673332 THAP1 THAP domain containing 1 2 2
MIRT673351 SLC35F6 solute carrier family 35 member F6 2 2
MIRT673667 ZNF440 zinc finger protein 440 2 2
MIRT673904 DCTN6 dynactin subunit 6 2 2
MIRT674096 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT674401 MYCBP MYC binding protein 2 2
MIRT674525 PRR23A proline rich 23A 2 2
MIRT674793 NPR1 natriuretic peptide receptor 1 2 2
MIRT674833 ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 2 2
MIRT675066 FGD6 FYVE, RhoGEF and PH domain containing 6 2 2
MIRT675080 CCR6 C-C motif chemokine receptor 6 2 2
MIRT675126 FSD2 fibronectin type III and SPRY domain containing 2 2 2
MIRT679401 IL10RB interleukin 10 receptor subunit beta 2 2
MIRT689229 RPS19 ribosomal protein S19 2 2
MIRT694008 PPIL4 peptidylprolyl isomerase like 4 2 2
MIRT699671 SFT2D2 SFT2 domain containing 2 2 2
MIRT706213 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT706548 GJD2 gap junction protein delta 2 2 2
MIRT707418 RRP7A ribosomal RNA processing 7 homolog A 2 2
MIRT710648 GLUL glutamate-ammonia ligase 2 2
MIRT719393 NPCA1 Nasopharyngeal carcinoma 1 2 2
MIRT720166 PNPO pyridoxamine 5'-phosphate oxidase 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4708-5p Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4708-5p Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4708-5p Tripterygium wilfordii Hook F sensitive tissue
hsa-miR-4708-5p Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-4708-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4708-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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