miRTarBase - #MIRT470034


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pre-miRNA Information
pre-miRNA hsa-mir-758   
Genomic Coordinates chr14: 101026020 - 101026107
Synonyms MIRN758, hsa-mir-758, MIR758
Description Homo sapiens miR-758 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-758-5p
Sequence 15| GAUGGUUGACCAGAGAGCACAC |36
Evidence Experimental
Experiments SOLiD
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 16 14 + 101026049 29233923 MiREDiBase
A-to-I 21 14 + 101026054 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs372417522 1 dbSNP
rs748092616 2 dbSNP
rs1270901332 4 dbSNP
rs1364206491 5 dbSNP
rs1483583954 8 dbSNP
rs770931807 10 dbSNP
rs776760808 11 dbSNP
rs1360350664 12 dbSNP
rs759742151 13 dbSNP
rs1002938972 15 dbSNP
rs770107042 17 dbSNP
rs369242818 20 dbSNP
rs1217090272 21 dbSNP
rs763341052 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PTP4A1   
Synonyms HH72, PRL-1, PRL1, PTP(CAAX1), PTPCAAX1
Description protein tyrosine phosphatase type IVA, member 1
Transcript NM_003463   
Expression
Putative miRNA Targets on PTP4A1
3'UTR of PTP4A1
(miRNA target sites are highlighted)		 
>PTP4A1|NM_003463|3'UTR
   1 AATTGGGGTGCCTAATGCTACTGGAAGTGGAACTTGAGATAGGGCCTAATTTGTTATACATATTAGCCAACATGTTGGCT
  81 TAGTAAGTCTAATGAAGCTTCCATAGGAGTATTGAAAGGCAGTTTTACCAGGCCTCAAGCTAGACAGATTTGGCAACCTC
 161 TGTATTTGGGTTACAGTCAACCTATTTGGATACTTGGCAAAAGATTCTTGCTGTCAGCATATAAAATGTGCTTGTCATTT
 241 GTATCAATTGACCTTTCCCCAAATCATGCAGTATTGAGTTATGACTTGTTAAATCTATTCCCATGCCAGAATCTTATCAA
 321 TACATAAGAAATTTAGGAAGATTAGGTGCCAAAATACCCAGCACAATACTTGTATATTTTTAGTACCATACAGAAGTAAA
 401 ATCCCAGGAACTATGAACACTAGACCTTATGTGGTTTATTCCTTCAATCATTTCAAACATTGAAAGTAGGGCCTACATGG
 481 TTATTTGCCTGCTCACTTTATGTTTACATCTCCCACATTCATACCAATATACGTCAGGTTTGCTTAACCATTGATTTTTT
 561 TTTTTTTTTACCAAGTCTTACAGTGATTATTTTACGTGTTTCCATGTATCTCACTTTGTGCTGTATTAAAAAAACCTCCA
 641 TTTTGAAAATCTACGTTGTACAGAAGCACATGTCTTTAATGTCTTCAGACAAAAAAGCCTTACATTAATTTAATGTTTGC
 721 ACTCTGAGGTGCAACTTAACAGGGAGGGCCTGAGAAAAGAATGGGAGGGGGCTATTAATTATTTTTAGCAAAATGTTGCC
 801 TTTGTCTTGTGCAAACATGTAGAATATGCTCTTTAATTTAGTAAAATATTTTTTTAAAAGGTAGAGATGCTTTGTTATTG
 881 TAATCATAAACTTCCTGAAATTCTTGTAATTTTTTTCCCATACTTATCAGAAGTGTGTTTACCAACTTATTTTTGTTTGA
 961 AAGTGTGATTTTTTTTTTCCTTCCCAACCTCTCTTGCAAAAAAAGAAATGGGTTTCTGCTAATGAATTGAGCAGACATCT
1041 AATATTTTATATGCCTTTTGAGCTGTGTAACTTAATATTTGGATACTTGACAATTTGTTTTATTATGTAATTGATAAAAT
1121 GGTGATGTGTATTAATGTTAGTTCAACCATATATTTATACTGTCTGGGGATGTGTGGTTATAGTTCTGTGGGAGAAATAA
1201 TTTTGTCAGTGTTCACCAGCTTGTAAAAACTTAGTGCGAGAGCTGAAACATCTAAATAAATAATGACATGCATTTATCAT
1281 CATTGAGATTGGTTTGCTTAAAATTAACTTATTTTGTAGAAGACAAAATGAATTGCACTTCACTTAATGTGTGTCCTCAT
1361 CTTTTTACAAATAAATGAAGGATTATAAATGATGTCAGCATTTTAGTAAACTTTTAGACAAAATTTGTTAGGGTCATTCA
1441 TGAAAACTTTAATACTAAAAGCACTTTCCATTATATACTTTTTAAAGGTCTAGATAATTTTGAACCAATTTATTATTGTG
1521 TACTGAGGAGAAATAATGTATAGTAGAGGACAGCCTTGGTTTGTAAAGCTCAGTTCCACTAGTTCATGGTTTTGTGCAAC
1601 TTCTGAGCCTCAGTTTTCTCCTTTGCAAATTAATAATTACATACCTTTATAGATTTTGAAATTAATTTAAATATTAGTAT
1681 TTGGTACATGAAGGCTTAATGTTAAGTTTCCTTTAATGATCCACAATAATCCCTTTGATCACGTTAATCTAAATCTAGAT
1761 GTCTTTGTCTAATTTTTTTTGAATAGCAGTTATAAATGTAAAGGACTCAAAGTTTAAGTAAAAAGTGATACTCCACCTTG
1841 TGTTTCAAAGAATTTAGTTCCACCTCTTCATACCAGTTTAACACTTAATATATTTCATTGGATTTTAGACAGGGCAAAAG
1921 GAAGAACAGGGGCCTCTGGAGGCCCTTGGTTATTTAAATCTTGGATTATTTGTGATAGTAATCACAAATTTTTGGCTAAT
2001 TTTTAACCTGAGGTTTTGTTTTTTTTTTAAAGGAAATGCAGCCTAGTCTTGAGAACATAATTTTATATAATCAATTACTA
2081 AATGTTAAACTATTACCACACAGCCCATAAAACAGCATTTGCGTTTATTGAGAGAGAGGATGTGCCATCATGATTAATGA
2161 AAACTATCTTTTGAGTTTGAAAAGAAATTAATTTGCAGTGTTTGGATTGTATATATGGTGCTAAAAATAAATTAATTTAC
2241 TTTATAAACCTTATCTGTACATTATACGATGTGATGAAATTTGCTTTTTATCCAAATATTTTGTATCTTGTAAATATGGC
2321 TAATTATAGGAATGCCTATAATACATCTTAGATTCCTTATATCTAATAAGAGTTCAAAGAGTTATGAGTTGAAGTCTTGA
2401 ATGCAGGAAACTATCTGATAGTGTTCTAAAATTTGGTTACTTGGGTTTGGATACCCTTAGTGGGATGATGTAAATAGAGG
2481 CTAGCTACCTAGGCTTGTCTATAGCAACCATAATGTTGATGTAAGTAATGCGGTTACTGAATCATAAGAAAATGCCATCT
2561 CTTTTTAGTTGAAGGAAAACTCTGGAAGTAGGTGCCATTGGTCATTCTGCAGTGCACTGCAACCATTGTTTCCCCTAGTG
2641 CCCTCTTTTCCCTAGGGCATTGCTCTCCTATTCCCACGCCTTAACACAGCTCTATACCTAGAAGCAGCCAGCCCAGGCAT
2721 GCAGTCACATTTAATCACATCCCCCTTCTAGAGTGCTTCAAAATGATGTAGTCCCTCAACTTGGCTAAAGAATCTCAATC
2801 TCTTGAAATTTATTTTTTTAATGTCATATTCATCTGGTAAATATCTACTGTTTGCCAGGCATTTAAGAATATGGCAAAGA
2881 ACATAAAAGATGGTGTCACCAGATTTTGGTCACCAATGAGTACCCGACCCGTTGCCATGATTAAGAGAGAATGCTTTCTA
2961 TTGGAGTTTCAGGAAATATAATTTGAGAATACTTTAAAGGGAAGTGGAAGTATAAGTGAATGATATTTTTCTTTTACATG
3041 TAAACAATGAAGTTATTTCAAAGTTAAGTTTTAAACAAAATACATGAAGTAGTGTCTGCCATACATGTTAATATTCTACA
3121 TTCTTGCTTCCTTAAATTAATATGTTTGTGTGTATATATGTGCCTCACACCTGAATTGAAAATTAAAGACTGGTTTAAAA
3201 GTGGTTTAAAAGTGACATTTAATGTTTCTCCATTACGTTTGGGGTAACCAGCCTAAGTGGAATCTTGGAAGGAAAGTAAG
3281 GGAAAAACTTGTATTTGCCTTCAATGAATTAAACCAGTGATATGTGTTAACGTATGAATGAAAGGATTGATGGTGATTTT
3361 ATAATTATATATATTGCCGCAGTAACCAGTTAATAAATTGATAGCTACCATTTAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cacACGAGAGACCAGUUGGUAg 5'
             || ||| | | ||||||| 
Target 5' gctTG-TCTATAG-CAACCATa 3'
 2493 - 2512 153.00 -12.30
2 
miRNA  3' cacacgAGAGACCAGUUGGUAg 5'
                | |: | |||||||| 
Target 5' tattaaTGTTAGTTCAACCATa 3'
 1130 - 1151 152.00 -10.20
3 
miRNA  3' caCACGAGAGACCAGUUGGUAg 5'
            |||| ||   | ||||||| 
Target 5' caGTGCACT---G-CAACCATt 3'
 2610 - 2627 152.00 -14.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26990936 14 COSMIC
COSN31556559 23 COSMIC
COSN30183253 38 COSMIC
COSN21591070 54 COSMIC
COSN31522651 398 COSMIC
COSN31550806 405 COSMIC
COSN31528121 554 COSMIC
COSN31608917 683 COSMIC
COSN9312841 700 COSMIC
COSN8514597 759 COSMIC
COSN26602783 770 COSMIC
COSN30175323 917 COSMIC
COSN29963709 1014 COSMIC
COSN31596190 1099 COSMIC
COSN2169992 1153 COSMIC
COSN31481074 1246 COSMIC
COSN31531290 1274 COSMIC
COSN31579449 1375 COSMIC
COSN5089770 1476 COSMIC
COSN26462966 1604 COSMIC
COSN7793035 1608 COSMIC
COSN216807 1614 COSMIC
COSN7890900 1759 COSMIC
COSN21109793 1823 COSMIC
COSN24348269 2017 COSMIC
COSN27540584 2029 COSMIC
COSN31572096 2112 COSMIC
COSN31577475 2119 COSMIC
COSN31520440 2185 COSMIC
COSN31523965 2277 COSMIC
COSN15118226 2519 COSMIC
COSN2169993 2682 COSMIC
COSN2169994 2790 COSMIC
COSN20091411 3064 COSMIC
COSN29080816 3088 COSMIC
COSN21563770 3134 COSMIC
COSN15812872 3183 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs773911774 3 dbSNP
rs759225817 5 dbSNP
rs766997007 6 dbSNP
rs1258211789 9 dbSNP
rs1263172553 10 dbSNP
rs752197709 11 dbSNP
rs1180193368 13 dbSNP
rs947354115 15 dbSNP
rs764372362 22 dbSNP
rs200202391 32 dbSNP
rs528551398 33 dbSNP
rs753655665 34 dbSNP
rs1221153968 35 dbSNP
rs757095424 37 dbSNP
rs1313855669 41 dbSNP
rs201134694 42 dbSNP
rs1359101883 43 dbSNP
rs776990512 46 dbSNP
rs778739544 47 dbSNP
rs1300594108 49 dbSNP
rs546765127 51 dbSNP
rs1339757576 68 dbSNP
rs924676907 69 dbSNP
rs934725267 84 dbSNP
rs1363187862 90 dbSNP
rs1458098386 105 dbSNP
rs1350770391 128 dbSNP
rs1167328526 129 dbSNP
rs1477084276 130 dbSNP
rs1423510517 131 dbSNP
rs1195064144 132 dbSNP
rs1057247916 135 dbSNP
rs1265366884 139 dbSNP
rs1209408156 140 dbSNP
rs1488923586 142 dbSNP
rs1186324232 144 dbSNP
rs1267531399 152 dbSNP
rs1196498116 154 dbSNP
rs73449618 159 dbSNP
rs188079207 175 dbSNP
rs1220423043 179 dbSNP
rs549704309 185 dbSNP
rs1343014787 187 dbSNP
rs1163264886 199 dbSNP
rs1300005114 207 dbSNP
rs1386902600 208 dbSNP
rs1389246473 211 dbSNP
rs1407529861 214 dbSNP
rs1324761914 217 dbSNP
rs1044297073 219 dbSNP
rs1464347435 220 dbSNP
rs899091126 222 dbSNP
rs1432988965 226 dbSNP
rs762004879 228 dbSNP
rs994790770 234 dbSNP
rs550469155 236 dbSNP
rs1198245745 238 dbSNP
rs1026380336 241 dbSNP
rs754227038 244 dbSNP
rs1269714347 246 dbSNP
rs1177024018 247 dbSNP
rs111875888 248 dbSNP
rs6924622 252 dbSNP
rs750484690 254 dbSNP
rs1314054630 259 dbSNP
rs1018715394 268 dbSNP
rs758456442 270 dbSNP
rs1255407593 272 dbSNP
rs1233301976 279 dbSNP
rs965887168 281 dbSNP
rs1306579794 284 dbSNP
rs749193001 289 dbSNP
rs569510631 290 dbSNP
rs1332447662 291 dbSNP
rs1449557478 294 dbSNP
rs1400658624 303 dbSNP
rs921465138 307 dbSNP
rs751501531 309 dbSNP
rs539083897 311 dbSNP
rs1211615873 317 dbSNP
rs1157008243 318 dbSNP
rs1439330841 324 dbSNP
rs1290465702 335 dbSNP
rs754973205 342 dbSNP
rs1445983838 345 dbSNP
rs1180271707 358 dbSNP
rs1206266852 366 dbSNP
rs979008497 369 dbSNP
rs1440525282 371 dbSNP
rs180745441 373 dbSNP
rs184765607 374 dbSNP
rs924595649 387 dbSNP
rs781076434 397 dbSNP
rs1238870845 399 dbSNP
rs1353969821 410 dbSNP
rs559984995 410 dbSNP
rs1241599683 414 dbSNP
rs1339104410 417 dbSNP
rs1183391094 420 dbSNP
rs1367138555 422 dbSNP
rs1473963639 425 dbSNP
rs1164412449 431 dbSNP
rs1296404612 437 dbSNP
rs1057457457 446 dbSNP
rs2758267 448 dbSNP
rs948501708 457 dbSNP
rs555164323 458 dbSNP
rs1471659909 462 dbSNP
rs1455726312 467 dbSNP
rs1044244334 470 dbSNP
rs1425474732 477 dbSNP
rs2758268 489 dbSNP
rs1261029628 495 dbSNP
rs1215226287 497 dbSNP
rs1488361938 499 dbSNP
rs1322555035 506 dbSNP
rs575129323 508 dbSNP
rs753663327 509 dbSNP
rs1283984212 511 dbSNP
rs1246058827 512 dbSNP
rs1357912454 515 dbSNP
rs748014364 517 dbSNP
rs994742866 522 dbSNP
rs1361272719 524 dbSNP
rs1318320905 528 dbSNP
rs1403827532 530 dbSNP
rs1390364589 531 dbSNP
rs533971648 533 dbSNP
rs1473679910 539 dbSNP
rs2758269 544 dbSNP
rs1421367717 551 dbSNP
rs886080283 554 dbSNP
rs1210775616 555 dbSNP
rs1290228365 555 dbSNP
rs1491409745 555 dbSNP
rs202116148 555 dbSNP
rs542201012 555 dbSNP
rs772510538 555 dbSNP
rs79929566 555 dbSNP
rs76908809 556 dbSNP
rs113906878 570 dbSNP
rs1337467316 570 dbSNP
rs1019073942 571 dbSNP
rs759160228 573 dbSNP
rs1328311769 577 dbSNP
rs1226074853 579 dbSNP
rs1269426056 580 dbSNP
rs1462778155 580 dbSNP
rs536018709 582 dbSNP
rs1397891356 583 dbSNP
rs995920367 590 dbSNP
rs1202688786 594 dbSNP
rs1466084777 597 dbSNP
rs878873664 604 dbSNP
rs1421633316 609 dbSNP
rs369278315 610 dbSNP
rs1170290662 613 dbSNP
rs1477430865 616 dbSNP
rs1246904181 620 dbSNP
rs1200576670 623 dbSNP
rs11969294 626 dbSNP
rs968889378 628 dbSNP
rs1198478733 629 dbSNP
rs1444555017 636 dbSNP
rs1275773128 640 dbSNP
rs1217529351 650 dbSNP
rs190476543 653 dbSNP
rs748811837 654 dbSNP
rs879457337 655 dbSNP
rs1374303922 656 dbSNP
rs1330405697 663 dbSNP
rs1447327178 670 dbSNP
rs558527340 687 dbSNP
rs1471872052 690 dbSNP
rs1173923493 691 dbSNP
rs1161486938 704 dbSNP
rs1413357202 705 dbSNP
rs770300964 709 dbSNP
rs1425298357 714 dbSNP
rs1412853011 715 dbSNP
rs1175056066 724 dbSNP
rs992851539 725 dbSNP
rs545892823 734 dbSNP
rs1469327261 735 dbSNP
rs917272685 737 dbSNP
rs1458533216 743 dbSNP
rs1404600709 747 dbSNP
rs1208685011 749 dbSNP
rs1441849369 758 dbSNP
rs1397574604 766 dbSNP
rs1334521407 767 dbSNP
rs1279443421 772 dbSNP
rs1349821520 774 dbSNP
rs1236672162 775 dbSNP
rs1407973788 778 dbSNP
rs564540070 779 dbSNP
rs1375287637 792 dbSNP
rs1300970406 801 dbSNP
rs1359730738 801 dbSNP
rs948781821 801 dbSNP
rs1314172366 805 dbSNP
rs1417364751 810 dbSNP
rs1350650779 812 dbSNP
rs1359473758 818 dbSNP
rs573134809 831 dbSNP
rs980210514 832 dbSNP
rs1420004892 835 dbSNP
rs1410622134 849 dbSNP
rs1253898177 856 dbSNP
rs540761372 861 dbSNP
rs1258917228 871 dbSNP
rs1213076605 872 dbSNP
rs144114658 878 dbSNP
rs1285521523 879 dbSNP
rs1217663298 880 dbSNP
rs1318433197 894 dbSNP
rs1310327663 895 dbSNP
rs1346606271 897 dbSNP
rs768085658 901 dbSNP
rs1272678673 902 dbSNP
rs1482263215 906 dbSNP
rs920396898 909 dbSNP
rs930480814 910 dbSNP
rs538473796 917 dbSNP
rs1347822918 921 dbSNP
rs529056697 928 dbSNP
rs886363847 933 dbSNP
rs1480183821 936 dbSNP
rs2734850 953 dbSNP
rs773853267 959 dbSNP
rs944652333 963 dbSNP
rs1476860224 966 dbSNP
rs1486969627 969 dbSNP
rs376737099 969 dbSNP
rs879220346 969 dbSNP
rs879876837 969 dbSNP
rs1379622340 979 dbSNP
rs1466702324 980 dbSNP
rs1167533907 982 dbSNP
rs1220528555 983 dbSNP
rs1369764204 984 dbSNP
rs1427579636 985 dbSNP
rs747455425 988 dbSNP
rs1274926067 989 dbSNP
rs900199537 990 dbSNP
rs1339200300 991 dbSNP
rs570954323 992 dbSNP
rs1383485876 994 dbSNP
rs550331872 996 dbSNP
rs1292638443 998 dbSNP
rs1436150192 999 dbSNP
rs562456039 1000 dbSNP
rs1167647867 1010 dbSNP
rs1298503801 1014 dbSNP
rs1332482627 1017 dbSNP
rs1233578975 1020 dbSNP
rs1171188793 1030 dbSNP
rs1022015146 1033 dbSNP
rs551839415 1042 dbSNP
rs1190859722 1043 dbSNP
rs1296372144 1046 dbSNP
rs1468698920 1047 dbSNP
rs1254668063 1048 dbSNP
rs904678828 1050 dbSNP
rs1032306301 1059 dbSNP
rs866798243 1072 dbSNP
rs181737298 1075 dbSNP
rs1309960173 1076 dbSNP
rs1275989668 1085 dbSNP
rs1300119637 1090 dbSNP
rs993526651 1093 dbSNP
rs1328328877 1094 dbSNP
rs1488401475 1101 dbSNP
rs1445081363 1104 dbSNP
rs1208157849 1110 dbSNP
rs1400180366 1111 dbSNP
rs1299263144 1149 dbSNP
rs1024294513 1150 dbSNP
rs1375999753 1152 dbSNP
rs551362053 1154 dbSNP
rs537940663 1158 dbSNP
rs1454860071 1161 dbSNP
rs970058852 1162 dbSNP
rs1176515549 1163 dbSNP
rs1433812742 1163 dbSNP
rs759222983 1169 dbSNP
rs1457195205 1178 dbSNP
rs1192830327 1182 dbSNP
rs1197518094 1189 dbSNP
rs1388540473 1209 dbSNP
rs1254917859 1211 dbSNP
rs1234458771 1227 dbSNP
rs1447453559 1228 dbSNP
rs980158276 1230 dbSNP
rs556588695 1238 dbSNP
rs1308252591 1239 dbSNP
rs566506782 1251 dbSNP
rs1393658639 1257 dbSNP
rs983294473 1261 dbSNP
rs1371125557 1262 dbSNP
rs1302326316 1264 dbSNP
rs1435463991 1274 dbSNP
rs978807403 1280 dbSNP
rs1457298578 1282 dbSNP
rs922014172 1292 dbSNP
rs1157107586 1293 dbSNP
rs907738566 1300 dbSNP
rs944619170 1304 dbSNP
rs1183832706 1309 dbSNP
rs1386837752 1309 dbSNP
rs1040724651 1313 dbSNP
rs574957972 1319 dbSNP
rs1255469241 1320 dbSNP
rs1210950872 1321 dbSNP
rs1283387528 1322 dbSNP
rs900150479 1322 dbSNP
rs1215447745 1323 dbSNP
rs1231078227 1325 dbSNP
rs527282058 1325 dbSNP
rs542397468 1331 dbSNP
rs534580688 1335 dbSNP
rs1051948107 1338 dbSNP
rs549111165 1339 dbSNP
rs371977963 1341 dbSNP
rs1267754113 1345 dbSNP
rs1043419325 1347 dbSNP
rs903620837 1349 dbSNP
rs1357485853 1350 dbSNP
rs1246431332 1352 dbSNP
rs1296511088 1356 dbSNP
rs1419345842 1356 dbSNP
rs1386024113 1358 dbSNP
rs567326333 1359 dbSNP
rs1456235788 1362 dbSNP
rs536080435 1368 dbSNP
rs773256959 1374 dbSNP
rs1188613145 1377 dbSNP
rs1053288837 1380 dbSNP
rs1390608757 1382 dbSNP
rs891985104 1387 dbSNP
rs1447210141 1392 dbSNP
rs1014479356 1395 dbSNP
rs1037104271 1398 dbSNP
rs1162673924 1399 dbSNP
rs1354719243 1405 dbSNP
rs761409438 1412 dbSNP
rs896855225 1412 dbSNP
rs1062179 1415 dbSNP
rs1234449314 1423 dbSNP
rs1024579137 1426 dbSNP
rs1276373376 1427 dbSNP
rs1430187352 1428 dbSNP
rs970005052 1434 dbSNP
rs771764111 1437 dbSNP
rs1384825192 1444 dbSNP
rs1393460617 1448 dbSNP
rs146443685 1454 dbSNP
rs1027691066 1455 dbSNP
rs1421472549 1468 dbSNP
rs1457981133 1469 dbSNP
rs763266300 1471 dbSNP
rs983964817 1473 dbSNP
rs907686028 1474 dbSNP
rs569458079 1478 dbSNP
rs1196349913 1481 dbSNP
rs766304644 1482 dbSNP
rs1252781720 1488 dbSNP
rs1214773280 1494 dbSNP
rs1470219166 1495 dbSNP
rs751704599 1504 dbSNP
rs1214039958 1505 dbSNP
rs1436895826 1507 dbSNP
rs1320777955 1510 dbSNP
rs866058268 1512 dbSNP
rs975949239 1513 dbSNP
rs1370604285 1522 dbSNP
rs921855027 1540 dbSNP
rs1442879685 1542 dbSNP
rs1048106424 1547 dbSNP
rs540155068 1554 dbSNP
rs1328130295 1555 dbSNP
rs1001309217 1561 dbSNP
rs931615716 1574 dbSNP
rs1062180 1575 dbSNP
rs1394641301 1577 dbSNP
rs1035510563 1579 dbSNP
rs1477485422 1590 dbSNP
rs561990964 1597 dbSNP
rs77882330 1602 dbSNP
rs754953096 1614 dbSNP
rs1062182 1617 dbSNP
rs924990858 1627 dbSNP
rs1470148804 1629 dbSNP
rs1236842392 1631 dbSNP
rs935079125 1635 dbSNP
rs1438409786 1645 dbSNP
rs1052644664 1646 dbSNP
rs1062183 1649 dbSNP
rs891938529 1650 dbSNP
rs1266267103 1652 dbSNP
rs573197502 1653 dbSNP
rs1045979116 1656 dbSNP
rs1062184 1658 dbSNP
rs1209638521 1662 dbSNP
rs1236154466 1662 dbSNP
rs1062185 1668 dbSNP
rs1062186 1682 dbSNP
rs1237110842 1688 dbSNP
rs1278820007 1689 dbSNP
rs1442857123 1690 dbSNP
rs1482836420 1691 dbSNP
rs1062187 1693 dbSNP
rs767630066 1695 dbSNP
rs1258187810 1696 dbSNP
rs1433607444 1701 dbSNP
rs1010187909 1708 dbSNP
rs1020627821 1712 dbSNP
rs1455805203 1714 dbSNP
rs752513401 1717 dbSNP
rs1406257451 1723 dbSNP
rs140927727 1726 dbSNP
rs1470795568 1727 dbSNP
rs952170773 1727 dbSNP
rs1235138471 1733 dbSNP
rs1409181984 1741 dbSNP
rs1485396977 1743 dbSNP
rs978776401 1743 dbSNP
rs371491460 1744 dbSNP
rs921983051 1752 dbSNP
rs1351166330 1759 dbSNP
rs144571773 1763 dbSNP
rs1283283121 1764 dbSNP
rs1270370803 1766 dbSNP
rs1358161166 1771 dbSNP
rs965867728 1773 dbSNP
rs975896808 1773 dbSNP
rs953471896 1781 dbSNP
rs186956654 1787 dbSNP
rs1314265504 1790 dbSNP
rs953295725 1791 dbSNP
rs1304919836 1805 dbSNP
rs1380561642 1809 dbSNP
rs544280994 1812 dbSNP
rs575033403 1816 dbSNP
rs1401696453 1817 dbSNP
rs1410735276 1826 dbSNP
rs1163437297 1827 dbSNP
rs1286965366 1829 dbSNP
rs1352474832 1830 dbSNP
rs1474885173 1832 dbSNP
rs1229065678 1835 dbSNP
rs1258335721 1835 dbSNP
rs979343828 1836 dbSNP
rs1310594185 1837 dbSNP
rs1485015648 1843 dbSNP
rs1241785554 1855 dbSNP
rs940934433 1866 dbSNP
rs924961611 1872 dbSNP
rs935008153 1876 dbSNP
rs1052150297 1877 dbSNP
rs1232615350 1878 dbSNP
rs191348222 1883 dbSNP
rs760012553 1886 dbSNP
rs917664095 1889 dbSNP
rs1036575192 1894 dbSNP
rs920861477 1899 dbSNP
rs930950145 1902 dbSNP
rs1360807105 1906 dbSNP
rs1289105740 1907 dbSNP
rs906054274 1911 dbSNP
rs937562993 1916 dbSNP
rs1257488560 1918 dbSNP
rs778219091 1928 dbSNP
rs1419299754 1929 dbSNP
rs1181451369 1931 dbSNP
rs181201842 1933 dbSNP
rs905600159 1949 dbSNP
rs1001278203 1957 dbSNP
rs1056886237 1959 dbSNP
rs1014976785 1961 dbSNP
rs185421858 1964 dbSNP
rs1177767424 1968 dbSNP
rs901916695 1979 dbSNP
rs560149022 1982 dbSNP
rs997598121 1989 dbSNP
rs1429502649 1990 dbSNP
rs1306780625 1992 dbSNP
rs1216194460 1994 dbSNP
rs1372881793 1998 dbSNP
rs777648977 2012 dbSNP
rs369141968 2014 dbSNP
rs1215978629 2016 dbSNP
rs1365781921 2018 dbSNP
rs1324303093 2019 dbSNP
rs1440685172 2019 dbSNP
rs561884512 2019 dbSNP
rs953243740 2021 dbSNP
rs979291546 2023 dbSNP
rs1032675771 2029 dbSNP
rs1354018932 2047 dbSNP
rs146224762 2051 dbSNP
rs869233616 2051 dbSNP
rs1430516510 2058 dbSNP
rs1020177948 2068 dbSNP
rs1062193 2075 dbSNP
rs988202142 2078 dbSNP
rs917628598 2088 dbSNP
rs1194008242 2089 dbSNP
rs1000185087 2093 dbSNP
rs763561170 2097 dbSNP
rs756944897 2101 dbSNP
rs953441387 2102 dbSNP
rs1206092411 2103 dbSNP
rs927415510 2108 dbSNP
rs937512306 2109 dbSNP
rs987590011 2123 dbSNP
rs1019457111 2124 dbSNP
rs1476736146 2129 dbSNP
rs145585575 2130 dbSNP
rs888034721 2130 dbSNP
rs1463635217 2131 dbSNP
rs370018421 2135 dbSNP
rs1373811498 2141 dbSNP
rs1036771033 2154 dbSNP
rs1192630315 2159 dbSNP
rs901868935 2166 dbSNP
rs962210602 2167 dbSNP
rs567385578 2169 dbSNP
rs865990966 2170 dbSNP
rs1251213336 2172 dbSNP
rs1449253453 2173 dbSNP
rs1178413952 2174 dbSNP
rs377511267 2175 dbSNP
rs1279115389 2179 dbSNP
rs1211166038 2182 dbSNP
rs563779284 2182 dbSNP
rs1029048282 2185 dbSNP
rs1237383056 2198 dbSNP
rs888908590 2202 dbSNP
rs1308365478 2203 dbSNP
rs1389140682 2223 dbSNP
rs1353643620 2225 dbSNP
rs1411690397 2225 dbSNP
rs1000660389 2228 dbSNP
rs1032207436 2232 dbSNP
rs956829990 2233 dbSNP
rs920841115 2234 dbSNP
rs988098668 2235 dbSNP
rs1364261560 2236 dbSNP
rs970394220 2236 dbSNP
rs1473902550 2237 dbSNP
rs1256213956 2241 dbSNP
rs1188128201 2246 dbSNP
rs531469914 2249 dbSNP
rs549881852 2250 dbSNP
rs1323450437 2256 dbSNP
rs930919121 2256 dbSNP
rs1203706345 2262 dbSNP
rs980491818 2268 dbSNP
rs983748431 2269 dbSNP
rs569483309 2277 dbSNP
rs926994585 2280 dbSNP
rs909421836 2286 dbSNP
rs1415522725 2291 dbSNP
rs539603824 2306 dbSNP
rs1342467452 2317 dbSNP
rs937016024 2318 dbSNP
rs1056843513 2322 dbSNP
rs895573802 2329 dbSNP
rs138377681 2335 dbSNP
rs1227437527 2360 dbSNP
rs1041972015 2380 dbSNP
rs1459798175 2382 dbSNP
rs1417127247 2385 dbSNP
rs1036647368 2386 dbSNP
rs1475914677 2387 dbSNP
rs1192026500 2411 dbSNP
rs1370943521 2411 dbSNP
rs1446721611 2416 dbSNP
rs1344016908 2419 dbSNP
rs56092815 2423 dbSNP
rs933343677 2424 dbSNP
rs1273167441 2438 dbSNP
rs1233926448 2441 dbSNP
rs1050435111 2451 dbSNP
rs182142056 2455 dbSNP
rs1000154491 2464 dbSNP
rs770046674 2469 dbSNP
rs1226986035 2471 dbSNP
rs1327309983 2479 dbSNP
rs114380593 2481 dbSNP
rs796557917 2482 dbSNP
rs1393577245 2486 dbSNP
rs1326532462 2489 dbSNP
rs1223050101 2496 dbSNP
rs148836788 2503 dbSNP
rs777170355 2504 dbSNP
rs77638186 2505 dbSNP
rs556228099 2511 dbSNP
rs1475533472 2514 dbSNP
rs962464703 2515 dbSNP
rs892327790 2519 dbSNP
rs577779458 2520 dbSNP
rs1024909515 2521 dbSNP
rs1187090437 2530 dbSNP
rs748711583 2532 dbSNP
rs1001879003 2542 dbSNP
rs1028276612 2547 dbSNP
rs1453343477 2571 dbSNP
rs1270956925 2572 dbSNP
rs1033380517 2575 dbSNP
rs527571720 2578 dbSNP
rs1163249126 2580 dbSNP
rs1340291157 2596 dbSNP
rs980954777 2597 dbSNP
rs1231751727 2602 dbSNP
rs1369983454 2608 dbSNP
rs41271559 2609 dbSNP
rs527559577 2612 dbSNP
rs1333972643 2613 dbSNP
rs992917750 2617 dbSNP
rs763634136 2626 dbSNP
rs1371972960 2631 dbSNP
rs1171402460 2636 dbSNP
rs962251453 2641 dbSNP
rs916994247 2642 dbSNP
rs1194719330 2645 dbSNP
rs945810969 2647 dbSNP
rs542927405 2649 dbSNP
rs1479288469 2658 dbSNP
rs560895729 2664 dbSNP
rs1181114657 2665 dbSNP
rs1438495724 2666 dbSNP
rs1322776192 2672 dbSNP
rs773629881 2674 dbSNP
rs374199722 2675 dbSNP
rs1280772092 2676 dbSNP
rs1050380794 2678 dbSNP
rs1348429177 2678 dbSNP
rs910574733 2679 dbSNP
rs1050297466 2682 dbSNP
rs1351808013 2683 dbSNP
rs1310636215 2689 dbSNP
rs889057625 2693 dbSNP
rs772186322 2695 dbSNP
rs1375753710 2707 dbSNP
rs1177206292 2709 dbSNP
rs1229566433 2722 dbSNP
rs188804782 2724 dbSNP
rs143383339 2736 dbSNP
rs1009404456 2742 dbSNP
rs564780489 2754 dbSNP
rs1158498576 2761 dbSNP
rs1472923372 2766 dbSNP
rs1254052199 2769 dbSNP
rs1185982886 2778 dbSNP
rs1327842392 2779 dbSNP
rs897903440 2785 dbSNP
rs1258543353 2787 dbSNP
rs529848475 2788 dbSNP
rs994029417 2791 dbSNP
rs1314942744 2810 dbSNP
rs1206478499 2815 dbSNP
rs760621290 2827 dbSNP
rs1249492062 2829 dbSNP
rs1046314343 2833 dbSNP
rs1331216807 2834 dbSNP
rs1290904328 2839 dbSNP
rs1232196587 2842 dbSNP
rs1355642507 2842 dbSNP
rs906441522 2850 dbSNP
rs1002160639 2851 dbSNP
rs1033328203 2853 dbSNP
rs1458226271 2853 dbSNP
rs1005687044 2873 dbSNP
rs1447952625 2877 dbSNP
rs1474935198 2880 dbSNP
rs1015363103 2889 dbSNP
rs1027742300 2894 dbSNP
rs771243454 2896 dbSNP
rs1484738248 2906 dbSNP
rs1241297637 2909 dbSNP
rs1187201101 2912 dbSNP
rs1466177417 2912 dbSNP
rs1271251863 2914 dbSNP
rs1212476277 2915 dbSNP
rs1334919555 2916 dbSNP
rs972248011 2917 dbSNP
rs1002341144 2919 dbSNP
rs770351711 2920 dbSNP
rs1474033425 2921 dbSNP
rs1269945808 2924 dbSNP
rs774569208 2927 dbSNP
rs960967983 2931 dbSNP
rs16894460 2932 dbSNP
rs1350554742 2935 dbSNP
rs1167076862 2938 dbSNP
rs916934290 2939 dbSNP
rs1419130851 2944 dbSNP
rs967150032 2949 dbSNP
rs1188946269 2959 dbSNP
rs977534441 2969 dbSNP
rs767544031 2980 dbSNP
rs1455711255 2981 dbSNP
rs910523597 2990 dbSNP
rs935800042 2992 dbSNP
rs1488797119 2994 dbSNP
rs1266693053 2995 dbSNP
rs1050276190 2996 dbSNP
rs936703435 2997 dbSNP
rs989931628 3008 dbSNP
rs551647998 3027 dbSNP
rs868057717 3032 dbSNP
rs944655639 3039 dbSNP
rs1440803317 3040 dbSNP
rs1369006675 3041 dbSNP
rs1401076610 3045 dbSNP
rs1333212681 3046 dbSNP
rs148386120 3049 dbSNP
rs897781398 3054 dbSNP
rs527561067 3056 dbSNP
rs764862887 3061 dbSNP
rs1431339472 3066 dbSNP
rs1192843750 3073 dbSNP
rs1393020033 3073 dbSNP
rs1049106580 3077 dbSNP
rs1269436046 3081 dbSNP
rs763735118 3085 dbSNP
rs1174921365 3086 dbSNP
rs1480042765 3088 dbSNP
rs1252005661 3091 dbSNP
rs1002309990 3092 dbSNP
rs1278628024 3094 dbSNP
rs888088609 3097 dbSNP
rs549260888 3100 dbSNP
rs1033836876 3102 dbSNP
rs1372712651 3105 dbSNP
rs1389706436 3105 dbSNP
rs80179967 3106 dbSNP
rs79583695 3108 dbSNP
rs1062324 3117 dbSNP
rs1373914021 3118 dbSNP
rs1021207313 3120 dbSNP
rs1172757542 3130 dbSNP
rs750167521 3132 dbSNP
rs1379254975 3134 dbSNP
rs1156844115 3135 dbSNP
rs1277012675 3137 dbSNP
rs1412048734 3147 dbSNP
rs1444462620 3151 dbSNP
rs556623561 3151 dbSNP
rs192094607 3157 dbSNP
rs756851742 3159 dbSNP
rs1484470286 3177 dbSNP
rs1251705372 3181 dbSNP
rs1471656819 3184 dbSNP
rs374652157 3191 dbSNP
rs1258223336 3203 dbSNP
rs1237500968 3208 dbSNP
rs143177086 3216 dbSNP
rs1477793473 3217 dbSNP
rs1289028954 3219 dbSNP
rs1230362544 3227 dbSNP
rs1171014538 3232 dbSNP
rs1353742546 3234 dbSNP
rs183620608 3237 dbSNP
rs763277881 3238 dbSNP
rs986322069 3265 dbSNP
rs1017813797 3273 dbSNP
rs1286961853 3278 dbSNP
rs1313423481 3282 dbSNP
rs1412672029 3289 dbSNP
rs1160717602 3298 dbSNP
rs1416664340 3318 dbSNP
rs957139678 3324 dbSNP
rs989489337 3325 dbSNP
rs1407492436 3326 dbSNP
rs1258692902 3327 dbSNP
rs573279992 3332 dbSNP
rs878969336 3333 dbSNP
rs1269346855 3337 dbSNP
rs910428295 3338 dbSNP
rs982222091 3339 dbSNP
rs1283759812 3347 dbSNP
rs1245780136 3351 dbSNP
rs1342559306 3352 dbSNP
rs147516767 3364 dbSNP
rs1272716737 3365 dbSNP
rs937849158 3366 dbSNP
rs1350580708 3368 dbSNP
rs1389232107 3369 dbSNP
rs1055011359 3370 dbSNP
rs1211968637 3372 dbSNP
rs370752378 3373 dbSNP
rs757854112 3379 dbSNP
rs542990796 3380 dbSNP
rs1207407903 3392 dbSNP
rs929275018 3394 dbSNP
rs779568583 3395 dbSNP
rs764388811 3401 dbSNP
rs887849112 3410 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cacacgAGAGACCAGUUGGUAg 5'
                | |: | |||||||| 
Target 5' -auuaaUGUUAGUUCAACCAUa 3'
 		1 - 21
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000370651.3 | 3UTR | AUUAAUGUUAGUUCAACCAUAUAUUUAUACUGUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
62 hsa-miR-758-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT085323 MORC3 MORC family CW-type zinc finger 3 2 2
MIRT089441 STAMBP STAM binding protein 2 2
MIRT089456 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT111856 CCND1 cyclin D1 2 2
MIRT184933 ZNF268 zinc finger protein 268 2 2
MIRT215288 CREBRF CREB3 regulatory factor 2 2
MIRT237300 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT238446 MYO10 myosin X 2 4
MIRT273827 RPL41 ribosomal protein L41 2 2
MIRT282703 HOOK1 hook microtubule tethering protein 1 2 2
MIRT347970 ZNF850 zinc finger protein 850 2 2
MIRT371076 KLF3 Kruppel like factor 3 2 2
MIRT464339 USP6NL USP6 N-terminal like 2 2
MIRT470034 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT477506 ELL2 elongation factor for RNA polymerase II 2 2 2
MIRT482886 CACNA2D3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 2 2
MIRT492606 POLR3E RNA polymerase III subunit E 2 2
MIRT502294 GNG12 G protein subunit gamma 12 2 6
MIRT507600 DCTN4 dynactin subunit 4 2 4
MIRT510728 SON SON DNA binding protein 2 6
MIRT514065 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 8
MIRT519718 ZNF512B zinc finger protein 512B 2 4
MIRT520890 STRN striatin 2 2
MIRT521760 PPIL1 peptidylprolyl isomerase like 1 2 6
MIRT526874 ERCC8 ERCC excision repair 8, CSA ubiquitin ligase complex subunit 2 2
MIRT530232 WSB2 WD repeat and SOCS box containing 2 2 2
MIRT532003 ACTR2 ARP2 actin related protein 2 homolog 2 2
MIRT533371 UBE2D4 ubiquitin conjugating enzyme E2 D4 (putative) 2 4
MIRT547106 PIGW phosphatidylinositol glycan anchor biosynthesis class W 2 2
MIRT548189 FOXA1 forkhead box A1 2 2
MIRT552935 VKORC1L1 vitamin K epoxide reductase complex subunit 1 like 1 2 2
MIRT560085 ZNF195 zinc finger protein 195 2 2
MIRT561726 PPP2CA protein phosphatase 2 catalytic subunit alpha 2 2
MIRT562713 ZNF415 zinc finger protein 415 2 2
MIRT562761 ZNF846 zinc finger protein 846 2 2
MIRT564159 ZNF117 zinc finger protein 117 2 2
MIRT565673 SETD5 SET domain containing 5 2 2
MIRT565718 SESN3 sestrin 3 2 2
MIRT566026 RFX1 regulatory factor X1 2 2
MIRT569048 ZNF655 zinc finger protein 655 2 2
MIRT570367 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT570410 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT570443 TMEM189 transmembrane protein 189 2 2
MIRT571738 RNF11 ring finger protein 11 2 2
MIRT575042 Tpgs2 tubulin polyglutamylase complex subunit 2 2 4
MIRT614330 ZDHHC22 zinc finger DHHC-type containing 22 2 2
MIRT617629 RAB3IP RAB3A interacting protein 2 2
MIRT621667 UBE4B ubiquitination factor E4B 2 2
MIRT639906 SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 2 2
MIRT651436 XRCC5 X-ray repair cross complementing 5 2 2
MIRT683853 ZNF208 zinc finger protein 208 2 2
MIRT684841 TPGS2 tubulin polyglutamylase complex subunit 2 2 5
MIRT689347 ZNF83 zinc finger protein 83 2 2
MIRT692492 SPIN4 spindlin family member 4 2 2
MIRT695711 OLA1 Obg like ATPase 1 2 2
MIRT698219 TMEM248 transmembrane protein 248 2 2
MIRT711560 FAM20B FAM20B, glycosaminoglycan xylosylkinase 2 2
MIRT712867 TMEM67 transmembrane protein 67 2 2
MIRT722956 TSPAN1 tetraspanin 1 2 2
MIRT723622 SOBP sine oculis binding protein homolog 2 2
MIRT724176 ABCF2 ATP binding cassette subfamily F member 2 2 2
MIRT755363 LMBR1 limb development membrane protein 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-758 Hydroxycamptothecin (HCPT) NULL 97226 Microarray human Tenon's fibroblasts (HTFs) 24681041 2014 down-regulated
miR-758 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miR-758 5-Fluorouracil approved 3385 Quantitative real-time PCR human squamous cell carcinoma cell line KYSE410 21743970 2011 up-regulated
miR-758 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-758 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-758 Fluorouracil 3385 NSC19893 approved resistant cell line (KYSE)
hsa-mir-758 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-758-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-758-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-758-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-758-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-758-5p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-758-5p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-758-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-758-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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