miRTarBase - #MIRT470281


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pre-miRNA Information
pre-miRNA hsa-mir-4491   
Genomic Coordinates chr11: 111347757 - 111347824
Description Homo sapiens miR-4491 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4491
Sequence 46| AAUGUGGACUGGUGUGACCAAA |67
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1043555759 4 dbSNP
rs1182248607 6 dbSNP
rs527936256 7 dbSNP
rs755554417 14 dbSNP
rs779628583 16 dbSNP
rs1471408223 19 dbSNP
rs909066815 20 dbSNP
Putative Targets

Gene Information
Gene Symbol PRKAA1   
Synonyms AMPK, AMPKa1
Description protein kinase AMP-activated catalytic subunit alpha 1
Transcript NM_006251   
Other Transcripts NM_206907   
Expression
Putative miRNA Targets on PRKAA1
3'UTR of PRKAA1
(miRNA target sites are highlighted)		 
>PRKAA1|NM_006251|3'UTR
   1 ACAGAAAACTTTGCTTATTTCTTTTGCAGCAATAAGCATGCATAATAAGTCACAGCCAAATGCTTCCATTTGTAATCAAG
  81 TTATACATAATTATAACCGAGGGCTGGCGTTTTGGAATGCAATTTGCACAGGGATTGGAACATGATTTATAGTTAAAAGC
 161 CTAATATGCAGAAATGAATTAAGATCATTTTGTTGTTCATTGTGCAGTATGTATATAGCATAATATACACAGTGAATTAT
 241 AGGTCTCAGGCTTACTTGATTTTTGGCTATTTTATATTTAGTGTACACAGGGCTTTGAAATATTAATTTACATAAAGGCC
 321 TTCATATATTATTACGTGTTATATATTACGTGTTATAAATTTATTCAATAAATATTTGCCTAGAATTCCCAAGACCTTTA
 401 TAGGTGATTTTGTTTTCTGGGCTCCTTAACTTCATAAATAGCTAGTATCTTCCAGCAGTAGTAACAGTCTGGATAACTTC
 481 TTCCATATCCCTCCCTCTTTGTTTTTTTGAGACAGTGTCACTTTGTCACCCAGGCTGGAGTGCAATGGTGTGGTCTCGGC
 561 TCACTGCAACCTCCACCTCCCGGGTTCAAGTGATTCTCCCGCCTCAGCTTCCTGAGTAGCTGGAACTACAGGCGTGTGCC
 641 ACCACACCCGGCTAATTTTTCGTATTTTTAGTGTAGACGGGGTTTCACTATGTTGCCCAGGCTGGTCTCGAACTCCTGAC
 721 CGCGTGATCCACCACCTCAGCTTCCCAAAGTGGTGGGATTACAGGCGTGAGCCACCGCACCCGGCCTCCATATCCCCCTT
 801 TTAAAATTCTGTAGTGTATGGTAAGTCATATCAGATATCAGACCTAATTTAAATTTCATTTTAGCTTTACAAGTCCAAAA
 881 ACACAGAATTTATATATTCAGATACTCTAGCACTAATTTTAGTCTTAAAATATTCCCACGATATTCTGTACACAAAATGT
 961 TCTTTTTGTTACAAGAGCTGAGTTGCATATACTGTAGATAAATCATATTATTTTTGCCAATTTCACAAATTCCTCTGGCC
1041 CATCATGTCAGTCATTATTGAGTATATGCACACATTGCTACTTATTTGATTATGTATCTTTTAAATTGATTCAGTGCATA
1121 GAAAACTATCTCTTACAAACTTTAAGTGCTCTGATATGACTTCCCCCCCAAATTTTATTATGAACATTTTTAAAAACAGA
1201 AAAATTGAAAAACTGTTTGGTAAGCACATGTATATCTACCATTTAGATTCAGCAGTTGTTAATGTTTTGTCATTTGTTTT
1281 CTCTATACCTATATATGTATAGATACAGCTAGTTATGCATATATATGCATATATGTGTTTGTTTGTGTATGTATATATGC
1361 TTTTTTCCCCCTGAACCATTTGGATGTTACAGACATACTTATCACCGTGAAAATACTTCAAGTATCTCCTACAGATAATG
1441 ACATTCTCCTAAAAATCCGTAATACCATTGTAAAAGTAATAATTCCCCAATATCATCTAATCAAGCCATATTTAAATTTC
1521 TGAAGTTAACTCCAAATTTCTTTATAGCTGATTATTTCAAACTAGGATCCAATTAAAGTTTACATATGACACTTGGTTAT
1601 AACTCTTTAGTTGGATATAACATTATTATTATTTTGATAAAATATGGAACAAATCAATTCTATTAATAAGTGGTCACATT
1681 TGTTTTGGGCTTAAATTACTTTTTAAAGATACTGGATTTTCCTAAGATTTCTGATTTACACTGATATTTTTTTTTGTCAT
1761 TCTTAATTGCATCACACAATAGATGTAAATGAAGATGTAGTCACCTCAGATAAAATTGGTATCGTGTATGATAATATTGT
1841 ATCATTTATATTTGCCTTATGTTAACTTTAAGAAATTGATTTTTTTGTATTAATCATTTTCCCATTGCAACAGAGCTATA
1921 TTTTTTCTATTTTAAGAATCATATTTTAGGATTATTTTTGGCAAATACAGTGAGCACTTATGTAACCAGATGATAATGAA
2001 CTCAAATGTCATGATAGCTTGCATAAATGGTGACTCTAGTAGATTTGACTCAAGCACTTCTAGAATCATGCACTGAATTC
2081 AAAAGAAAAATCTTGCTGCTTTTTGTCCAGGGCTTGTTCTATTCAACTTCTAATTTGAAAGCTGTACAAAGTAATAGAAG
2161 TTCCATTTAAATATGAGTTCAAAACTGTATTTACTTTTTATGTGGCCCTCTCTTTAGGGGATTCTAATTTTACTTAGGGT
2241 CTCTAAGTGCAGCATAATGTTCCTGATGTTAACAGAAGACTGTATTTTTAAAGTTACAAATTTGTATATGGAATTAAGTA
2321 ATGGCGCTATATACGCTGTTGTGGGGAGGGGGGAAGAAAAGGAGGAACCAATTAAATAGGACCTTTTAAAAATTGTTAAT
2401 TTTGTAAACTTTGCTTCTCTTATAAGTTATTGTGATTCATTTTAGTTACTGTGTTTTATTTTGAAAATATTTAAATATTG
2481 CACTTCTATAAATAGTATGATAAATGCACAGACAATTGCAGTAAATTCTTTTTTAAGCTAGGATATTTGAAATGACAACC
2561 TTTGGTTAAGTGTGTCAAGGTTGCAACAGAATTTTCACAATTTTTTTGTTGTTTGCAAATTGTTACTAATATTGAAGAGG
2641 TAAGGGAGGCAATGCAAATGATTTTTAATCTTTTTTTATTATCTTTTCAGCAGTTTATATTTTTTGTGACTTTATGCAAC
2721 CATATTTTTACTTTGTCTTGACAACTGAAAGATGTATAAGGTTTTTTGCCAGAAATGTACTGTATACATAGTTTTAAGTA
2801 TAACAGATTTTACTGATATGTAAAAATTTTGCCATTAAAATAAATGATTTCTCACTGAGAGGAACTTTTCTACCAGGTTG
2881 GGGCATATGGGAGCTTAATATATCATATCTAATTTAAAATAATTTCACTGAAATAAACTCCATTGCTTTTACCTAATTTT
2961 TTTCTTGAGATGCTTTTGTAGTTTTTCAGAGTTTTAGATGATTTTATACAAAATCCTCTGCCTAGCACTGCTCTTTTTGA
3041 TGTTGTAGTGACACCATTTACATTGAATTAATGCTTGGTAGCCTGGGGCTAGATGTGGAACTCCATGGATCTGTGTTCTG
3121 ACTGGCACCTTTGGAATGAAAGAAAAGTGTGTGCTGTCCAAATTTTTTCCCCTTAATTCTTTCCCTCATCTTCTCACCCA
3201 TAATAGAAATTTTATTTCCATTGTGAGTTCTGACAAGAATGAAATTCCACATACAACATAACTGTAAATTGTTGGTAGGT
3281 AGAAGTTAATATTTGTGGTTCATGTATATTTTGACCAGAGTATATTTAAGTATATAATTTCAGCTTCCTTGATTTAGAAA
3361 TATGATATAATAAAGAAAAACTCCATTTATCATCTGTTA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aaaccagUGUGGUCAGGUGUAa 5'
                 |::  | ||||||| 
Target 5' gacaagaATGAAATTCCACATa 3'
 3232 - 3253 143.00 -8.50
2 
miRNA  3' aaaccaGUGUGGUC---AGGUGUAa 5'
                |:|||| |   ||||:|| 
Target 5' agccacCGCACCCGGCCTCCATATc 3'
 770 - 794 140.00 -15.10
3 
miRNA  3' aaACCAGUGUGGUCAGGUGUAa 5'
            | || |||||| |::|||| 
Target 5' tgTAGTGACACCA-TTTACATt 3'
 3044 - 3064 139.00 -16.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31497176 5 COSMIC
COSN31571151 27 COSMIC
COSN30486563 48 COSMIC
COSN31504439 75 COSMIC
COSN26565368 98 COSMIC
COSN30452129 99 COSMIC
COSN30459318 114 COSMIC
COSN31598911 168 COSMIC
COSN26552013 169 COSMIC
COSN26672987 368 COSMIC
COSN26455372 601 COSMIC
COSN15985740 678 COSMIC
COSN5605475 1363 COSMIC
COSN20120215 1843 COSMIC
COSN32061035 1881 COSMIC
COSN31549503 2042 COSMIC
COSN21870894 2047 COSMIC
COSN31609745 2260 COSMIC
COSN30541553 2325 COSMIC
COSN31539612 2325 COSMIC
COSN31553402 2326 COSMIC
COSN8492777 2334 COSMIC
COSN22481121 2373 COSMIC
COSN16500072 2443 COSMIC
COSN31523065 2493 COSMIC
COSN31570658 2524 COSMIC
COSN31567586 2586 COSMIC
COSN30165186 2588 COSMIC
COSN31570666 2650 COSMIC
COSN31570184 2660 COSMIC
COSN31532987 2662 COSMIC
COSN31479617 2670 COSMIC
COSN31535815 2696 COSMIC
COSN31490102 2761 COSMIC
COSN6297151 3044 COSMIC
COSN4849891 3112 COSMIC
COSN19506432 3239 COSMIC
COSN20091186 3385 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1044253 2 dbSNP
rs1044254 4 dbSNP
rs1375114846 9 dbSNP
rs550631477 11 dbSNP
rs1267204323 13 dbSNP
rs765785940 13 dbSNP
rs1370256374 14 dbSNP
rs758084732 15 dbSNP
rs766848274 24 dbSNP
rs1221413815 26 dbSNP
rs762251206 26 dbSNP
rs920984352 32 dbSNP
rs1260166937 34 dbSNP
rs1212108053 35 dbSNP
rs1485530426 37 dbSNP
rs752177993 38 dbSNP
rs1217515466 44 dbSNP
rs1317070865 45 dbSNP
rs1305711149 46 dbSNP
rs371313459 47 dbSNP
rs532628920 48 dbSNP
rs750838337 50 dbSNP
rs565126169 53 dbSNP
rs1388341553 58 dbSNP
rs1195604413 62 dbSNP
rs1387584404 63 dbSNP
rs540568879 66 dbSNP
rs890697637 75 dbSNP
rs1267234991 77 dbSNP
rs1361637039 79 dbSNP
rs1026994106 87 dbSNP
rs1287373055 93 dbSNP
rs763546732 98 dbSNP
rs747144751 99 dbSNP
rs1037419557 108 dbSNP
rs528762464 109 dbSNP
rs894267989 112 dbSNP
rs994827914 122 dbSNP
rs574542332 125 dbSNP
rs938377896 159 dbSNP
rs1213173333 171 dbSNP
rs1294702692 174 dbSNP
rs1044852696 181 dbSNP
rs1014345440 194 dbSNP
rs1201606140 198 dbSNP
rs1240738268 199 dbSNP
rs542669433 201 dbSNP
rs1443309721 205 dbSNP
rs1183581897 209 dbSNP
rs1381273038 210 dbSNP
rs768221146 212 dbSNP
rs575564988 213 dbSNP
rs924523809 216 dbSNP
rs1421305162 221 dbSNP
rs1157409461 230 dbSNP
rs1344791473 247 dbSNP
rs778062822 250 dbSNP
rs1331217339 261 dbSNP
rs1052994948 269 dbSNP
rs1309938616 275 dbSNP
rs1300477441 281 dbSNP
rs1375469888 282 dbSNP
rs934552686 285 dbSNP
rs545630791 287 dbSNP
rs570597736 288 dbSNP
rs1398359717 297 dbSNP
rs1235028944 303 dbSNP
rs139553829 309 dbSNP
rs1429294257 312 dbSNP
rs975280868 318 dbSNP
rs1460514483 319 dbSNP
rs964789511 320 dbSNP
rs1239271918 321 dbSNP
rs1481927368 324 dbSNP
rs1175782348 335 dbSNP
rs910665411 336 dbSNP
rs1433970741 340 dbSNP
rs943836294 342 dbSNP
rs774965044 348 dbSNP
rs1382135067 349 dbSNP
rs954891149 350 dbSNP
rs1297380102 352 dbSNP
rs554691600 358 dbSNP
rs1368116747 359 dbSNP
rs1026525423 368 dbSNP
rs983662463 371 dbSNP
rs545475811 375 dbSNP
rs994162046 379 dbSNP
rs1197371784 391 dbSNP
rs1421406932 396 dbSNP
rs532169437 397 dbSNP
rs963696299 401 dbSNP
rs950955758 408 dbSNP
rs1274510987 421 dbSNP
rs1027834644 430 dbSNP
rs1203107536 442 dbSNP
rs973645776 449 dbSNP
rs375384537 452 dbSNP
rs183831823 467 dbSNP
rs1482498836 469 dbSNP
rs1489035666 485 dbSNP
rs1016382759 487 dbSNP
rs771723975 489 dbSNP
rs894215612 494 dbSNP
rs1480234387 495 dbSNP
rs558789481 500 dbSNP
rs1171402721 501 dbSNP
rs1022975712 506 dbSNP
rs1345093258 514 dbSNP
rs1056822558 516 dbSNP
rs1169700430 516 dbSNP
rs533936671 517 dbSNP
rs895922007 525 dbSNP
rs1031906698 530 dbSNP
rs1230887807 532 dbSNP
rs902851988 540 dbSNP
rs1041602093 543 dbSNP
rs745698469 545 dbSNP
rs1348454221 547 dbSNP
rs566791364 549 dbSNP
rs1272986958 554 dbSNP
rs554822271 557 dbSNP
rs192483418 558 dbSNP
rs932563276 560 dbSNP
rs1490243968 561 dbSNP
rs1194248111 563 dbSNP
rs1243883946 567 dbSNP
rs969621309 569 dbSNP
rs1474493658 570 dbSNP
rs1186024580 572 dbSNP
rs916384362 575 dbSNP
rs1414395173 581 dbSNP
rs1170910627 582 dbSNP
rs899489043 589 dbSNP
rs1364800184 598 dbSNP
rs1419925819 600 dbSNP
rs914535581 601 dbSNP
rs1039542208 612 dbSNP
rs942541711 613 dbSNP
rs910614715 618 dbSNP
rs758617536 619 dbSNP
rs1384104052 620 dbSNP
rs568817943 633 dbSNP
rs954698400 634 dbSNP
rs1205915089 644 dbSNP
rs919241946 645 dbSNP
rs972128499 648 dbSNP
rs1445524702 649 dbSNP
rs963945290 650 dbSNP
rs748249455 655 dbSNP
rs908316645 659 dbSNP
rs868645997 661 dbSNP
rs779187617 662 dbSNP
rs1035363814 672 dbSNP
rs1440134031 676 dbSNP
rs868764960 678 dbSNP
rs1382276938 679 dbSNP
rs534517133 689 dbSNP
rs749158711 690 dbSNP
rs1334230318 691 dbSNP
rs1003045062 696 dbSNP
rs1407746164 698 dbSNP
rs902967379 702 dbSNP
rs1020369336 705 dbSNP
rs1277219767 709 dbSNP
rs1198263441 710 dbSNP
rs1240153847 717 dbSNP
rs1281641361 720 dbSNP
rs111924809 721 dbSNP
rs929453755 722 dbSNP
rs532071268 723 dbSNP
rs1227771457 724 dbSNP
rs973593538 726 dbSNP
rs1326813911 729 dbSNP
rs1438359042 732 dbSNP
rs1183644983 736 dbSNP
rs1294912510 741 dbSNP
rs1361905163 748 dbSNP
rs1039658224 749 dbSNP
rs970319821 761 dbSNP
rs746897375 762 dbSNP
rs572235839 763 dbSNP
rs890969751 765 dbSNP
rs1340117001 766 dbSNP
rs1050947542 767 dbSNP
rs1332228287 771 dbSNP
rs552197873 776 dbSNP
rs1441715143 777 dbSNP
rs1284223929 780 dbSNP
rs558560354 782 dbSNP
rs1031730473 783 dbSNP
rs112080650 794 dbSNP
rs1159057895 795 dbSNP
rs767676019 796 dbSNP
rs1197549789 808 dbSNP
rs1021501257 816 dbSNP
rs996763015 818 dbSNP
rs1420388961 820 dbSNP
rs942054976 821 dbSNP
rs1164212120 837 dbSNP
rs1472899995 838 dbSNP
rs1479252875 839 dbSNP
rs561266626 840 dbSNP
rs1185025133 841 dbSNP
rs538512072 846 dbSNP
rs1041097485 853 dbSNP
rs1170193470 858 dbSNP
rs1394757163 869 dbSNP
rs1409701978 875 dbSNP
rs1304165942 876 dbSNP
rs991703768 882 dbSNP
rs958832186 895 dbSNP
rs1035813709 905 dbSNP
rs1403397458 913 dbSNP
rs751931572 921 dbSNP
rs981674569 930 dbSNP
rs943690131 932 dbSNP
rs886793593 935 dbSNP
rs1229489832 937 dbSNP
rs137946058 939 dbSNP
rs758375975 940 dbSNP
rs1020063731 953 dbSNP
rs1291701496 964 dbSNP
rs1011631816 978 dbSNP
rs1293687589 985 dbSNP
rs1228702067 1000 dbSNP
rs1198329392 1009 dbSNP
rs931074243 1011 dbSNP
rs1429830483 1013 dbSNP
rs892807696 1028 dbSNP
rs1037874954 1033 dbSNP
rs916133992 1044 dbSNP
rs993503568 1048 dbSNP
rs1422940426 1058 dbSNP
rs1293209076 1071 dbSNP
rs1229960190 1081 dbSNP
rs960026678 1092 dbSNP
rs1366017573 1118 dbSNP
rs1018167842 1119 dbSNP
rs924613547 1120 dbSNP
rs977494570 1127 dbSNP
rs1397350365 1128 dbSNP
rs1006802399 1140 dbSNP
rs766696335 1143 dbSNP
rs915415639 1144 dbSNP
rs569637543 1146 dbSNP
rs1405119901 1153 dbSNP
rs1260898470 1161 dbSNP
rs79292371 1163 dbSNP
rs1260452696 1164 dbSNP
rs996711995 1165 dbSNP
rs891086112 1166 dbSNP
rs1164551216 1170 dbSNP
rs1387447243 1170 dbSNP
rs34482915 1170 dbSNP
rs530852178 1171 dbSNP
rs1161091197 1175 dbSNP
rs1455548930 1181 dbSNP
rs1287174141 1185 dbSNP
rs929853840 1206 dbSNP
rs897876733 1212 dbSNP
rs1453250580 1214 dbSNP
rs1450953446 1218 dbSNP
rs556093072 1221 dbSNP
rs941996762 1224 dbSNP
rs909225382 1225 dbSNP
rs563699720 1226 dbSNP
rs1318289570 1232 dbSNP
rs1236506809 1234 dbSNP
rs1259595795 1236 dbSNP
rs1008565187 1238 dbSNP
rs1461416324 1238 dbSNP
rs1248352586 1242 dbSNP
rs1460372263 1243 dbSNP
rs991485793 1254 dbSNP
rs1251758874 1255 dbSNP
rs763565371 1260 dbSNP
rs1287548978 1269 dbSNP
rs1207475913 1272 dbSNP
rs928916555 1273 dbSNP
rs147350847 1285 dbSNP
rs1296903413 1287 dbSNP
rs766223652 1288 dbSNP
rs1226237165 1289 dbSNP
rs1447219849 1292 dbSNP
rs1298522718 1293 dbSNP
rs995216224 1296 dbSNP
rs1389298104 1299 dbSNP
rs567650373 1305 dbSNP
rs1323850419 1306 dbSNP
rs1275948869 1310 dbSNP
rs1436481923 1312 dbSNP
rs1224738550 1317 dbSNP
rs1260718309 1325 dbSNP
rs749973791 1332 dbSNP
rs1210113400 1334 dbSNP
rs898276847 1335 dbSNP
rs142677351 1339 dbSNP
rs1175875431 1341 dbSNP
rs188251829 1343 dbSNP
rs761427602 1347 dbSNP
rs1201614465 1351 dbSNP
rs527574612 1359 dbSNP
rs1427361328 1361 dbSNP
rs1370822361 1365 dbSNP
rs1017949809 1366 dbSNP
rs1356226542 1367 dbSNP
rs1307180288 1369 dbSNP
rs1345684352 1372 dbSNP
rs1447105355 1373 dbSNP
rs1006583108 1381 dbSNP
rs1280801611 1384 dbSNP
rs564824934 1401 dbSNP
rs955260829 1401 dbSNP
rs183113419 1402 dbSNP
rs573055558 1405 dbSNP
rs1029593031 1406 dbSNP
rs994382253 1407 dbSNP
rs938964712 1414 dbSNP
rs896990167 1421 dbSNP
rs1036821500 1424 dbSNP
rs1225090693 1431 dbSNP
rs924603172 1453 dbSNP
rs78955876 1458 dbSNP
rs887902922 1459 dbSNP
rs968777057 1462 dbSNP
rs1055705819 1467 dbSNP
rs191771027 1476 dbSNP
rs760301103 1484 dbSNP
rs1366033420 1490 dbSNP
rs41271117 1494 dbSNP
rs963887896 1495 dbSNP
rs1025530065 1501 dbSNP
rs201036313 1502 dbSNP
rs771680417 1505 dbSNP
rs763633699 1515 dbSNP
rs913390134 1518 dbSNP
rs1364633388 1520 dbSNP
rs990762351 1528 dbSNP
rs1297317358 1544 dbSNP
rs1360669965 1545 dbSNP
rs1225210989 1547 dbSNP
rs745530996 1551 dbSNP
rs1287939488 1557 dbSNP
rs1451252722 1559 dbSNP
rs1279428918 1584 dbSNP
rs1243975318 1594 dbSNP
rs957089442 1599 dbSNP
rs1187894446 1603 dbSNP
rs1385608293 1608 dbSNP
rs951397646 1621 dbSNP
rs911002559 1622 dbSNP
rs1412538575 1634 dbSNP
rs756469301 1636 dbSNP
rs985094952 1655 dbSNP
rs571778582 1657 dbSNP
rs955043514 1660 dbSNP
rs1410797711 1665 dbSNP
rs1029953729 1666 dbSNP
rs112364555 1671 dbSNP
rs1307009787 1679 dbSNP
rs574094026 1696 dbSNP
rs538204134 1706 dbSNP
rs1053115 1713 dbSNP
rs1016766314 1715 dbSNP
rs1044771030 1716 dbSNP
rs1005366492 1732 dbSNP
rs1286390398 1745 dbSNP
rs887852162 1746 dbSNP
rs144007197 1747 dbSNP
rs894631511 1747 dbSNP
rs1055821252 1748 dbSNP
rs1057489806 1748 dbSNP
rs1041999311 1756 dbSNP
rs200355780 1756 dbSNP
rs747503242 1756 dbSNP
rs1176170274 1758 dbSNP
rs571025042 1759 dbSNP
rs1423013036 1762 dbSNP
rs1184321084 1766 dbSNP
rs1001469349 1771 dbSNP
rs914593705 1776 dbSNP
rs1250889663 1777 dbSNP
rs1180204665 1793 dbSNP
rs1407402819 1802 dbSNP
rs1455104530 1804 dbSNP
rs770656233 1819 dbSNP
rs1046179142 1821 dbSNP
rs1443174865 1823 dbSNP
rs942806176 1824 dbSNP
rs1348899238 1829 dbSNP
rs1227792345 1832 dbSNP
rs1263849803 1839 dbSNP
rs1325575217 1847 dbSNP
rs1198731813 1864 dbSNP
rs1310563058 1871 dbSNP
rs1270547129 1873 dbSNP
rs1229606036 1875 dbSNP
rs1328900053 1876 dbSNP
rs1183759183 1879 dbSNP
rs1249076659 1880 dbSNP
rs1199486962 1887 dbSNP
rs1472065874 1887 dbSNP
rs912377948 1889 dbSNP
rs1468000092 1892 dbSNP
rs946315150 1911 dbSNP
rs913496256 1913 dbSNP
rs1054613755 1915 dbSNP
rs754262936 1927 dbSNP
rs1331297395 1948 dbSNP
rs1348797065 1949 dbSNP
rs1302877210 1950 dbSNP
rs1409505872 1955 dbSNP
rs866821024 1969 dbSNP
rs936166903 1981 dbSNP
rs546259444 1984 dbSNP
rs910950216 1986 dbSNP
rs1025479187 1989 dbSNP
rs534914424 1992 dbSNP
rs116202595 1999 dbSNP
rs1339994727 2001 dbSNP
rs1356988451 2003 dbSNP
rs955180396 2005 dbSNP
rs1161277856 2006 dbSNP
rs1457709575 2017 dbSNP
rs922285616 2023 dbSNP
rs1023287484 2027 dbSNP
rs1270386346 2032 dbSNP
rs1425742575 2034 dbSNP
rs1197584882 2037 dbSNP
rs1053116 2049 dbSNP
rs1053117 2059 dbSNP
rs1053118 2065 dbSNP
rs1377496453 2069 dbSNP
rs1011981300 2073 dbSNP
rs972852173 2078 dbSNP
rs1369166950 2093 dbSNP
rs896265355 2094 dbSNP
rs1304037545 2096 dbSNP
rs1181552215 2101 dbSNP
rs1367711770 2110 dbSNP
rs1482307465 2117 dbSNP
rs1250050210 2126 dbSNP
rs1209828974 2127 dbSNP
rs1322986696 2129 dbSNP
rs1464850293 2139 dbSNP
rs1266570571 2143 dbSNP
rs549459484 2144 dbSNP
rs1035855562 2148 dbSNP
rs1322739768 2160 dbSNP
rs1312971991 2163 dbSNP
rs1227455172 2164 dbSNP
rs961301017 2178 dbSNP
rs1487304832 2187 dbSNP
rs1017295889 2188 dbSNP
rs1208669440 2189 dbSNP
rs1261891598 2197 dbSNP
rs566919666 2202 dbSNP
rs1448079130 2208 dbSNP
rs983892551 2215 dbSNP
rs1191102231 2218 dbSNP
rs1388687882 2221 dbSNP
rs1449195081 2226 dbSNP
rs1379858717 2238 dbSNP
rs903354889 2239 dbSNP
rs1435668345 2258 dbSNP
rs187426278 2263 dbSNP
rs1370355057 2272 dbSNP
rs1387860210 2278 dbSNP
rs1456633270 2281 dbSNP
rs1293007309 2287 dbSNP
rs1183257471 2293 dbSNP
rs1385808926 2294 dbSNP
rs747388870 2297 dbSNP
rs563790226 2299 dbSNP
rs1287089103 2311 dbSNP
rs1364410845 2313 dbSNP
rs1453013609 2318 dbSNP
rs183137075 2326 dbSNP
rs1368892118 2334 dbSNP
rs1243700317 2335 dbSNP
rs907317973 2341 dbSNP
rs761327542 2345 dbSNP
rs1206312309 2346 dbSNP
rs1422286357 2347 dbSNP
rs1024289716 2349 dbSNP
rs1464846923 2353 dbSNP
rs1184575422 2354 dbSNP
rs1392036618 2355 dbSNP
rs942795355 2361 dbSNP
rs912669942 2369 dbSNP
rs533337978 2379 dbSNP
rs552023341 2379 dbSNP
rs986909191 2383 dbSNP
rs559917899 2384 dbSNP
rs112954658 2416 dbSNP
rs541524635 2422 dbSNP
rs765955309 2424 dbSNP
rs573113864 2426 dbSNP
rs112913361 2430 dbSNP
rs1387743839 2439 dbSNP
rs1470297250 2464 dbSNP
rs973950020 2474 dbSNP
rs1489009573 2477 dbSNP
rs1265233021 2478 dbSNP
rs1307209007 2480 dbSNP
rs892017582 2490 dbSNP
rs190893022 2495 dbSNP
rs1351983916 2496 dbSNP
rs1054729735 2499 dbSNP
rs1220302236 2502 dbSNP
rs1267000359 2515 dbSNP
rs936114697 2519 dbSNP
rs962627224 2523 dbSNP
rs1258109164 2531 dbSNP
rs542409179 2533 dbSNP
rs1228457710 2537 dbSNP
rs1482452679 2539 dbSNP
rs889965762 2542 dbSNP
rs184910517 2544 dbSNP
rs933753979 2549 dbSNP
rs756017135 2557 dbSNP
rs1391091680 2558 dbSNP
rs1470226973 2570 dbSNP
rs796808896 2575 dbSNP
rs1178205485 2576 dbSNP
rs556941253 2578 dbSNP
rs1035143408 2579 dbSNP
rs1465329023 2582 dbSNP
rs1298540435 2593 dbSNP
rs1371965126 2600 dbSNP
rs972414332 2601 dbSNP
rs1407681439 2608 dbSNP
rs1287119740 2611 dbSNP
rs1345645650 2621 dbSNP
rs1220474506 2626 dbSNP
rs1292741648 2632 dbSNP
rs1303999528 2642 dbSNP
rs939696057 2642 dbSNP
rs909781289 2652 dbSNP
rs1252317432 2655 dbSNP
rs984008497 2657 dbSNP
rs959167954 2659 dbSNP
rs1422920556 2662 dbSNP
rs1203330919 2665 dbSNP
rs748230047 2668 dbSNP
rs1480778614 2671 dbSNP
rs1193026278 2678 dbSNP
rs1372673689 2686 dbSNP
rs1422898673 2688 dbSNP
rs1169509065 2706 dbSNP
rs1432540150 2706 dbSNP
rs1391821496 2709 dbSNP
rs1020492918 2714 dbSNP
rs1306968720 2734 dbSNP
rs1365840338 2740 dbSNP
rs1011815514 2744 dbSNP
rs1291301076 2752 dbSNP
rs781324065 2753 dbSNP
rs1201560066 2754 dbSNP
rs971490567 2755 dbSNP
rs1434270032 2769 dbSNP
rs1344819868 2776 dbSNP
rs1267053541 2788 dbSNP
rs1189876458 2792 dbSNP
rs1452414079 2794 dbSNP
rs1024821683 2796 dbSNP
rs35980452 2796 dbSNP
rs1223791785 2803 dbSNP
rs1245119351 2804 dbSNP
rs1039697438 2816 dbSNP
rs1484265573 2818 dbSNP
rs1007266430 2819 dbSNP
rs1167730287 2825 dbSNP
rs1276312307 2829 dbSNP
rs755156746 2831 dbSNP
rs11559002 2838 dbSNP
rs1162087378 2844 dbSNP
rs538267468 2847 dbSNP
rs1249113770 2855 dbSNP
rs114336915 2883 dbSNP
rs1368016689 2884 dbSNP
rs1433267264 2893 dbSNP
rs1331630622 2902 dbSNP
rs1300284668 2910 dbSNP
rs1357308711 2924 dbSNP
rs930091997 2926 dbSNP
rs1287780897 2929 dbSNP
rs1321144750 2930 dbSNP
rs1402838625 2930 dbSNP
rs918402694 2933 dbSNP
rs1352151404 2937 dbSNP
rs1038207320 2942 dbSNP
rs1243598716 2952 dbSNP
rs1000442139 2954 dbSNP
rs890081848 2955 dbSNP
rs531993749 2956 dbSNP
rs1412652224 2958 dbSNP
rs1400745741 2964 dbSNP
rs934183399 2964 dbSNP
rs1160753809 2969 dbSNP
rs1429353458 2980 dbSNP
rs1394354398 2991 dbSNP
rs1391399553 2994 dbSNP
rs1174412786 2995 dbSNP
rs552683830 2998 dbSNP
rs900893956 3020 dbSNP
rs1320304619 3027 dbSNP
rs1341493215 3028 dbSNP
rs563183093 3031 dbSNP
rs1282600246 3033 dbSNP
rs1377532188 3034 dbSNP
rs1229018209 3036 dbSNP
rs939666416 3041 dbSNP
rs1326987365 3042 dbSNP
rs534410671 3043 dbSNP
rs1174970201 3045 dbSNP
rs567203353 3047 dbSNP
rs1253075868 3051 dbSNP
rs759987513 3055 dbSNP
rs1207795981 3065 dbSNP
rs549564686 3067 dbSNP
rs990755112 3070 dbSNP
rs1472723442 3074 dbSNP
rs960628382 3077 dbSNP
rs927665057 3083 dbSNP
rs926568754 3092 dbSNP
rs981936371 3099 dbSNP
rs1247738714 3101 dbSNP
rs1020460441 3102 dbSNP
rs34246121 3105 dbSNP
rs72747971 3105 dbSNP
rs1290255730 3117 dbSNP
rs917300647 3118 dbSNP
rs1018921586 3122 dbSNP
rs529744210 3123 dbSNP
rs956142634 3126 dbSNP
rs891109614 3128 dbSNP
rs1277729520 3140 dbSNP
rs1330866410 3144 dbSNP
rs552082851 3158 dbSNP
rs1033009687 3161 dbSNP
rs1000221103 3163 dbSNP
rs1288765683 3171 dbSNP
rs954265067 3178 dbSNP
rs1249188480 3179 dbSNP
rs1482417608 3184 dbSNP
rs1028594555 3185 dbSNP
rs1198955303 3195 dbSNP
rs1378658978 3196 dbSNP
rs747397692 3202 dbSNP
rs1409390832 3208 dbSNP
rs145077370 3218 dbSNP
rs1334235713 3221 dbSNP
rs998343138 3225 dbSNP
rs548581147 3227 dbSNP
rs1051127295 3233 dbSNP
rs141296428 3237 dbSNP
rs1396659215 3239 dbSNP
rs1310035397 3251 dbSNP
rs1401665344 3252 dbSNP
rs547955852 3254 dbSNP
rs529388835 3255 dbSNP
rs1368982214 3256 dbSNP
rs1409216424 3257 dbSNP
rs1324300179 3274 dbSNP
rs180893924 3280 dbSNP
rs1231069850 3283 dbSNP
rs190901221 3289 dbSNP
rs560801403 3298 dbSNP
rs1038425441 3306 dbSNP
rs541158100 3320 dbSNP
rs542821753 3328 dbSNP
rs888217672 3330 dbSNP
rs1048034396 3336 dbSNP
rs941158795 3337 dbSNP
rs1341035040 3341 dbSNP
rs1413082543 3347 dbSNP
rs937690250 3349 dbSNP
rs1453800698 3362 dbSNP
rs916435045 3363 dbSNP
rs926516503 3365 dbSNP
rs1450435934 3368 dbSNP
rs1055422648 3369 dbSNP
rs373859829 3369 dbSNP
rs1388492211 3370 dbSNP
rs539202961 3376 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aaaccaguguggUCAGGUGUAa 5'
                      | ||||||| 
Target 5' ----------aaAUUCCACAUa 3'
 		1 - 12
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000397128.2 | 3UTR | AAAUUCCACAUACAACAUAACUGUAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
67 hsa-miR-4491 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT056779 ARID5B AT-rich interaction domain 5B 2 2
MIRT061577 BTG2 BTG anti-proliferation factor 2 2 2
MIRT063828 SRP9 signal recognition particle 9 2 4
MIRT102306 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 2 10
MIRT186634 COX20 COX20, cytochrome c oxidase assembly factor 2 8
MIRT191243 STYX serine/threonine/tyrosine interacting protein 2 2
MIRT195908 SRSF11 serine and arginine rich splicing factor 11 2 4
MIRT240343 UBXN2B UBX domain protein 2B 2 2
MIRT271178 PTPN14 protein tyrosine phosphatase, non-receptor type 14 2 2
MIRT286219 TMEM97 transmembrane protein 97 2 4
MIRT314182 OCLN occludin 2 4
MIRT323938 AKAP2 A-kinase anchoring protein 2 2 4
MIRT323940 PALM2-AKAP2 PALM2-AKAP2 readthrough 2 4
MIRT340113 TXLNA taxilin alpha 2 2
MIRT450333 LRWD1 leucine rich repeats and WD repeat domain containing 1 2 2
MIRT451283 ZNF101 zinc finger protein 101 2 2
MIRT451879 SOD2 superoxide dismutase 2 2 8
MIRT453577 CRCP CGRP receptor component 2 2
MIRT454366 ASAH2 N-acylsphingosine amidohydrolase 2 2 2
MIRT454797 STOML3 stomatin like 3 2 2
MIRT459801 POTED POTE ankyrin domain family member D 2 10
MIRT460911 POLQ DNA polymerase theta 2 2
MIRT468082 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 6
MIRT470281 PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 2 2
MIRT471876 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT476147 GPR137C G protein-coupled receptor 137C 2 8
MIRT478056 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 10
MIRT501054 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 4
MIRT501732 OVOL1 ovo like transcriptional repressor 1 2 2
MIRT502214 HSPB8 heat shock protein family B (small) member 8 2 2
MIRT505243 UBE2D3 ubiquitin conjugating enzyme E2 D3 2 2
MIRT505957 RAN RAN, member RAS oncogene family 2 6
MIRT507996 BCL2L13 BCL2 like 13 2 4
MIRT510433 ZNF207 zinc finger protein 207 2 6
MIRT510827 SBNO1 strawberry notch homolog 1 2 4
MIRT511493 HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 2 4
MIRT512129 CREBL2 cAMP responsive element binding protein like 2 2 8
MIRT514512 SHISA9 shisa family member 9 2 4
MIRT516482 RAB32 RAB32, member RAS oncogene family 2 4
MIRT519514 RBM22 RNA binding motif protein 22 2 4
MIRT523367 GTF2A1 general transcription factor IIA subunit 1 2 2
MIRT524217 DDI2 DNA damage inducible 1 homolog 2 2 6
MIRT524649 C4orf32 family with sequence similarity 241 member A 2 2
MIRT528297 ZNF76 zinc finger protein 76 2 2
MIRT528577 ITGB3BP integrin subunit beta 3 binding protein 2 2
MIRT530458 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT535774 MYCN MYCN proto-oncogene, bHLH transcription factor 2 2
MIRT544239 CCBL2 kynurenine aminotransferase 3 2 2
MIRT546733 RNF217 ring finger protein 217 2 2
MIRT550360 INCENP inner centromere protein 2 4
MIRT553343 TRPC3 transient receptor potential cation channel subfamily C member 3 2 4
MIRT556629 LAPTM4A lysosomal protein transmembrane 4 alpha 2 2
MIRT558006 FAM122B family with sequence similarity 122B 2 2
MIRT558994 CA8 carbonic anhydrase 8 2 2
MIRT560418 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2 2
MIRT565717 SESN3 sestrin 3 2 2
MIRT566271 PTAR1 protein prenyltransferase alpha subunit repeat containing 1 2 2
MIRT568161 CCDC6 coiled-coil domain containing 6 2 2
MIRT569753 C2orf71 chromosome 2 open reading frame 71 2 2
MIRT573959 FIGNL1 fidgetin like 1 2 2
MIRT574530 PEG10 paternally expressed 10 2 2
MIRT609453 CCDC149 coiled-coil domain containing 149 2 2
MIRT614047 THBS2 thrombospondin 2 2 2
MIRT628418 ATMIN ATM interactor 2 2
MIRT689556 XPO6 exportin 6 2 2
MIRT725598 CDH7 cadherin 7 2 2
MIRT735561 TRIM7 tripartite motif containing 7 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated

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