miRTarBase - #MIRT470357


—
pre-miRNA Information
pre-miRNA hsa-mir-520a   
Genomic Coordinates chr19: 53690881 - 53690965
Description Homo sapiens miR-520a stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-520a-5p
Sequence 15| CUCCAGAGGGAAGUACUUUCU |35
Evidence Experimental
Experiments Array-cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1172516897 2 dbSNP
rs747333607 4 dbSNP
rs1186636488 5 dbSNP
rs1461358452 13 dbSNP
rs1238887108 14 dbSNP
rs1305652558 17 dbSNP
rs371672116 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PPP2R5E   
Synonyms B56E, B56epsilon
Description protein phosphatase 2 regulatory subunit B'epsilon
Transcript NM_006246   
Expression
Putative miRNA Targets on PPP2R5E
3'UTR of PPP2R5E
(miRNA target sites are highlighted)		 
>PPP2R5E|NM_006246|3'UTR
   1 CAAAAACAATGACAACAACATTACTAACCTGTGGAGTCACACGTTTATGTAGTAGAAGATGGAGCAACAGTTTTCTGTAT
  81 TGTGCAACTTTACAGTAGATTTCACCTTTGTTTCATTATTACAGCAGCACTGTATATACCTGTCTCTAAGTAAAGGAAAA
 161 AACAAAATAAGGACTTCAATCCAAAGTTTGGACAGTAGATGGACTTCTCAGAACTTTGCAAACATAATCATTGTTCTCAC
 241 CCTCTTTTAAAAAAAAAAATCGGTCTTCAAAGATCTGTTGATGAAATTGCTATGTTAAAATTCCATTATCGGGAGTTCCT
 321 TATTTATCACTAGCAGAGAGTATGATACAATTTTCAAATGTGAACAATCTTAAATTTAGCTTGTCTTTCTGCTAAGCTGT
 401 TAAATGTATTTATAGTAAAGGAAGAAAAAAAGACTGTCATTTCCTTATAAGTTTGTGTAACATCCTCCTCTGGATAACTT
 481 GACTGTAATTTAACATCTTTTTCTTTTGCACATCTTCCTGAGTTGAATGTCCACGTGGAATGGGGTCATGAATTATAAAA
 561 GTCCCTGATAAAAGTTTTGTTTACTGGGGTGAACATCTTTCCAGTAACCAGGTAGTCCTGGTACTCCTTTAGTTTTAAAA
 641 TTAGGAGTTAAGAGAGAAGAGGTGATAAACATAGTAGGGAAGGGAATATCGGATTCATGCATCAGTTTATGGTGAATCCA
 721 AATCAATGTCTTGAATCCTTTGAAAACAGGCACTGGGACATCACAGGCTTCAGTACCTGACCAGTATTAGTTGCATATAT
 801 CATTGAACACACATACCAGAGATGTTTTAGAAATGTGAGAAAAACATCCTTTTGGACCATTTGAAATAAGAAAGACAAAC
 881 ACTAAACAATACAACCATGAAATTGATCACCGGGATTGCAAATCTAATTGGGAAAAGAGTTGAGCAAACAGCTTGGACTG
 961 TTTGGAGTTGTTGCCTTACTTTTTAATATGTATTTATAAAGTATTCCAGCAAAAGAGGATGTAGCCTCTGGGAAAAAACA
1041 AACATGTTACAGTGTTTTTTGTAGATTCTCGTTCTATATCTCATCACAGCGCCAGCCCTGTTTTTAGCCGGAAAGGATTC
1121 AGGATAAACATTATTATGCATTCTGAATTGGATGCATATTCCTAACTACTGTATTTGTTACCAAAAGTGGTTCTACAAAT
1201 GCTACTGAAAAAAATCTGGAAATTCCTAATGTCCTGAGTATTAATAATAAAGTTTAAAAATGCTTTTATATCAAAGGTGC
1281 ATCGTGACCAAATTGTTTAAGAAAAAAAAACAAAAAAAACAAAATCTAGGGCTGTATTTTATATATATATATATATATAT
1361 ATATATATATATATCTTATTGGCTCTCTGCTTTGTATTTAAATGAAGAATCTTACATCTTGGGTAGGTAAACTGCTGATA
1441 AAATTTGTGTACAGTATGTACTTACCTAATGCAGTTGCATTATTACGTACTGAAAGATATGTGTTTGGAGGTTTATTTCC
1521 AGGATGCATTTGCTTGTTTTGGTCATGGCAGCAGTGAGTTGGTAATCCTAAACCATCACTTCCAGCAGTATTCATGGTAT
1601 AGAGCTGATCTGTGTTCATATGTTGAATTGTGATAGTAGCAAACATGAACATATGAACTATTGTTGCTCTTAATAGAAAT
1681 ACAATATAAATATGGGCTTGTATATTTTCTTCCTTACATTTAAATATAAAGTAGAATACGCAGTTTTATTATTTTCAAGA
1761 AAAAGAAAGAGAAGCTGCTGACCTTTCTCCCCCATAAAGTTTTTCAGGATGATCAGGTCACAGTGTGTACGTAAGAGTCA
1841 GCTAATTATGGATATTGTCATCTCGGTAACTTTGTAAAAAAACAAACAAAACTGGCATTGTTAATTCCAAAAAGAAAAAA
1921 AAAAGCAGTAAAAAAAAAAAGTCATATGCAACACCAGACGCAACATGGTTTAATGGAATTAATAGTTTTTTTTTTTTTTT
2001 TTTTAAAGAACATTGATGGGGATTCACTGTAAAGTTGGCAGAGGCTGCCAAAGACGAAACAACTGACTTTAAAAATGCTG
2081 GAACAATGTGATAAAAAATAAATTTGTAACAAATCTTAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucuuuCA-UGAAG--GGAGACCUc 5'
               || || ||  |||||||| 
Target 5' tttgtGTAACATCCTCCTCTGGAt 3'
 452 - 475 154.00 -13.40
2 
miRNA  3' ucUUUCAUG-AAGGGAGACCUc 5'
            |:|| |: |  |||||||: 
Target 5' aaAGAGGATGTAGCCTCTGGGa 3'
 1012 - 1033 139.00 -16.00
3 
miRNA  3' ucUUUCAUGAAGGGAGACCUc 5'
            :||  || |||:|:|||| 
Target 5' gaGAAAAACATCCTTTTGGAc 3'
 837 - 857 135.00 -15.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31501800 11 COSMIC
COSN30141457 43 COSMIC
COSN31610289 46 COSMIC
COSN31543521 69 COSMIC
COSN31486401 114 COSMIC
COSN31562085 156 COSMIC
COSN15949121 249 COSMIC
COSN20111397 249 COSMIC
COSN31594813 281 COSMIC
COSN26823055 357 COSMIC
COSN31595928 400 COSMIC
COSN31547683 424 COSMIC
COSN26554269 483 COSMIC
COSN31486364 604 COSMIC
COSN32146224 626 COSMIC
COSN31540116 691 COSMIC
COSN31532969 785 COSMIC
COSN28715024 836 COSMIC
COSN31587892 884 COSMIC
COSN31485330 917 COSMIC
COSN30543848 1007 COSMIC
COSN31518391 1053 COSMIC
COSN24028620 1143 COSMIC
COSN28739634 1205 COSMIC
COSN28732339 1310 COSMIC
COSN30175513 1312 COSMIC
COSN20111396 1317 COSMIC
COSN17920377 1339 COSMIC
COSN6256219 1429 COSMIC
COSN32061440 1986 COSMIC
COSN25399122 2135 COSMIC
COSN29819530 2300 COSMIC
COSN21005825 2694 COSMIC
COSN6256218 2760 COSMIC
COSN29511344 3181 COSMIC
COSN20783134 3247 COSMIC
COSN16610063 3426 COSMIC
COSN28320743 3920 COSMIC
COSN27062277 4401 COSMIC
COSN15313238 4646 COSMIC
rs3742625 3340 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1255553505 9 dbSNP
rs1213443869 11 dbSNP
rs1345169414 15 dbSNP
rs750088568 18 dbSNP
rs1337761301 20 dbSNP
rs764740985 25 dbSNP
rs1369149226 27 dbSNP
rs757082203 34 dbSNP
rs753525811 35 dbSNP
rs1357074244 36 dbSNP
rs535686605 42 dbSNP
rs368625038 43 dbSNP
rs373207681 44 dbSNP
rs767567924 48 dbSNP
rs759551784 50 dbSNP
rs774633765 51 dbSNP
rs1034936372 59 dbSNP
rs1438077418 81 dbSNP
rs751721196 87 dbSNP
rs961224095 96 dbSNP
rs1016748797 124 dbSNP
rs1165853803 128 dbSNP
rs751913915 132 dbSNP
rs1461865418 138 dbSNP
rs1325295301 142 dbSNP
rs1460863689 143 dbSNP
rs1166265036 145 dbSNP
rs1398670611 163 dbSNP
rs1410584884 166 dbSNP
rs1392131584 169 dbSNP
rs889836511 171 dbSNP
rs747617550 173 dbSNP
rs1454430811 179 dbSNP
rs1169450361 183 dbSNP
rs1049849904 184 dbSNP
rs1372261500 185 dbSNP
rs763879299 186 dbSNP
rs766658787 199 dbSNP
rs758882592 205 dbSNP
rs1190643780 214 dbSNP
rs1199356807 216 dbSNP
rs1260935277 221 dbSNP
rs530523318 233 dbSNP
rs998191325 240 dbSNP
rs1185818599 248 dbSNP
rs566668512 249 dbSNP
rs1053353665 254 dbSNP
rs546428232 256 dbSNP
rs1375256669 260 dbSNP
rs1462622161 260 dbSNP
rs34338079 260 dbSNP
rs398077807 260 dbSNP
rs79390014 260 dbSNP
rs796989375 260 dbSNP
rs926219060 260 dbSNP
rs1471039668 261 dbSNP
rs1192395340 262 dbSNP
rs1467540519 265 dbSNP
rs533053202 270 dbSNP
rs570415105 275 dbSNP
rs550570794 280 dbSNP
rs1326947523 304 dbSNP
rs184307511 310 dbSNP
rs562080203 311 dbSNP
rs1325285956 319 dbSNP
rs1196854301 322 dbSNP
rs1339191594 333 dbSNP
rs1249959110 338 dbSNP
rs866872031 342 dbSNP
rs1203859018 349 dbSNP
rs1267077499 350 dbSNP
rs1236849998 367 dbSNP
rs542110667 370 dbSNP
rs1302786319 371 dbSNP
rs1429568613 391 dbSNP
rs1198794170 397 dbSNP
rs528710965 398 dbSNP
rs1427241047 399 dbSNP
rs1438742158 408 dbSNP
rs1329304028 421 dbSNP
rs1363404946 425 dbSNP
rs559900221 428 dbSNP
rs542700196 432 dbSNP
rs960385063 446 dbSNP
rs1410448169 448 dbSNP
rs927649542 462 dbSNP
rs1385592955 465 dbSNP
rs191717254 467 dbSNP
rs752653799 478 dbSNP
rs577284737 481 dbSNP
rs1305936048 488 dbSNP
rs28366791 492 dbSNP
rs961567274 501 dbSNP
rs1262796775 503 dbSNP
rs528309073 507 dbSNP
rs1222334985 510 dbSNP
rs1267351446 512 dbSNP
rs1490872279 514 dbSNP
rs759514166 527 dbSNP
rs1200223909 530 dbSNP
rs371060022 534 dbSNP
rs1407601746 545 dbSNP
rs1160482165 548 dbSNP
rs1417491971 557 dbSNP
rs1161022479 560 dbSNP
rs1364114308 565 dbSNP
rs765772023 567 dbSNP
rs1436210977 582 dbSNP
rs1161641899 595 dbSNP
rs1395257806 604 dbSNP
rs1172505648 642 dbSNP
rs1405090723 646 dbSNP
rs1297052427 661 dbSNP
rs1370731937 664 dbSNP
rs1016865206 666 dbSNP
rs1309631912 668 dbSNP
rs983923116 669 dbSNP
rs953896732 670 dbSNP
rs138875399 671 dbSNP
rs1183238050 674 dbSNP
rs1362200552 677 dbSNP
rs1222413510 681 dbSNP
rs1437751640 682 dbSNP
rs1232304359 688 dbSNP
rs1248865039 689 dbSNP
rs574875559 690 dbSNP
rs998697574 691 dbSNP
rs546131047 704 dbSNP
rs555744766 714 dbSNP
rs1443853957 721 dbSNP
rs11556554 724 dbSNP
rs866776503 725 dbSNP
rs3742623 735 dbSNP
rs186835749 747 dbSNP
rs1169173833 749 dbSNP
rs1352210620 756 dbSNP
rs866418084 774 dbSNP
rs1463050421 793 dbSNP
rs1280201210 797 dbSNP
rs998884602 802 dbSNP
rs1442924948 808 dbSNP
rs1452436269 810 dbSNP
rs1313293190 815 dbSNP
rs1385621745 816 dbSNP
rs1229349834 829 dbSNP
rs3742624 836 dbSNP
rs1305881607 845 dbSNP
rs1206716318 857 dbSNP
rs539227936 859 dbSNP
rs1043297755 868 dbSNP
rs1460994503 869 dbSNP
rs1181529924 873 dbSNP
rs570553831 891 dbSNP
rs770787679 907 dbSNP
rs776711936 911 dbSNP
rs550389917 912 dbSNP
rs1429847389 924 dbSNP
rs1054869094 926 dbSNP
rs530465684 927 dbSNP
rs543482332 931 dbSNP
rs1467840985 939 dbSNP
rs1172679014 945 dbSNP
rs1335175556 954 dbSNP
rs1408826846 957 dbSNP
rs1449177574 963 dbSNP
rs1270200938 971 dbSNP
rs1360479308 976 dbSNP
rs1216415976 984 dbSNP
rs1278850209 987 dbSNP
rs1323137176 992 dbSNP
rs939068967 995 dbSNP
rs1265207130 996 dbSNP
rs1214799297 997 dbSNP
rs1240342026 1004 dbSNP
rs1161882782 1008 dbSNP
rs567717418 1011 dbSNP
rs547736490 1016 dbSNP
rs1193755417 1017 dbSNP
rs1427936828 1018 dbSNP
rs1479263331 1021 dbSNP
rs1178197368 1025 dbSNP
rs1412387974 1025 dbSNP
rs1415465033 1036 dbSNP
rs927753402 1038 dbSNP
rs528770409 1039 dbSNP
rs1433454974 1041 dbSNP
rs1470087256 1043 dbSNP
rs1345019241 1051 dbSNP
rs972769369 1055 dbSNP
rs1190555046 1056 dbSNP
rs1345960113 1061 dbSNP
rs939673986 1070 dbSNP
rs909790458 1071 dbSNP
rs984074972 1076 dbSNP
rs1257233597 1080 dbSNP
rs953843597 1086 dbSNP
rs1489677677 1090 dbSNP
rs779870394 1091 dbSNP
rs559763450 1109 dbSNP
rs1448956351 1110 dbSNP
rs1469250366 1115 dbSNP
rs976628259 1124 dbSNP
rs1406179929 1128 dbSNP
rs1223240912 1135 dbSNP
rs1349904330 1137 dbSNP
rs546400223 1138 dbSNP
rs965823904 1138 dbSNP
rs1403245311 1140 dbSNP
rs1304971188 1141 dbSNP
rs201970681 1152 dbSNP
rs1235033558 1154 dbSNP
rs532580889 1156 dbSNP
rs1441692717 1164 dbSNP
rs999229185 1165 dbSNP
rs1312040802 1166 dbSNP
rs904567673 1173 dbSNP
rs1291026262 1184 dbSNP
rs1021830067 1187 dbSNP
rs1013150364 1189 dbSNP
rs894743833 1193 dbSNP
rs1057477603 1204 dbSNP
rs1346539246 1215 dbSNP
rs1234227002 1217 dbSNP
rs1442003705 1226 dbSNP
rs938864506 1229 dbSNP
rs1318432774 1231 dbSNP
rs1385173932 1240 dbSNP
rs760250557 1248 dbSNP
rs1385770873 1251 dbSNP
rs1167799257 1263 dbSNP
rs563844970 1279 dbSNP
rs1409426456 1281 dbSNP
rs906239615 1283 dbSNP
rs1379383408 1284 dbSNP
rs1447268100 1286 dbSNP
rs1475814784 1288 dbSNP
rs1380534861 1299 dbSNP
rs1417681070 1301 dbSNP
rs1186179232 1302 dbSNP
rs1036815393 1303 dbSNP
rs939663445 1310 dbSNP
rs1199669529 1311 dbSNP
rs1255560199 1311 dbSNP
rs1457887945 1311 dbSNP
rs1242872644 1313 dbSNP
rs909569546 1316 dbSNP
rs1369520456 1319 dbSNP
rs1166176221 1320 dbSNP
rs1402742212 1320 dbSNP
rs1475161510 1320 dbSNP
rs1466306032 1321 dbSNP
rs1215290149 1323 dbSNP
rs201955171 1324 dbSNP
rs1224628203 1325 dbSNP
rs1397530314 1325 dbSNP
rs575194200 1325 dbSNP
rs984027484 1325 dbSNP
rs1445397561 1338 dbSNP
rs1318187648 1339 dbSNP
rs1260837537 1340 dbSNP
rs1176414535 1341 dbSNP
rs1446866059 1341 dbSNP
rs71120259 1341 dbSNP
rs1425806797 1342 dbSNP
rs1275110440 1343 dbSNP
rs1427552330 1343 dbSNP
rs867043715 1344 dbSNP
rs1215554518 1345 dbSNP
rs1188220147 1346 dbSNP
rs1335321735 1348 dbSNP
rs1292462660 1349 dbSNP
rs1303153322 1349 dbSNP
rs1226352093 1350 dbSNP
rs1363676727 1352 dbSNP
rs1340646121 1353 dbSNP
rs902988892 1355 dbSNP
rs1313529358 1359 dbSNP
rs1235898480 1360 dbSNP
rs1270453942 1361 dbSNP
rs1203944811 1365 dbSNP
rs1429567870 1367 dbSNP
rs146817267 1367 dbSNP
rs1362479882 1368 dbSNP
rs1327330071 1369 dbSNP
rs1462434863 1370 dbSNP
rs1176563299 1371 dbSNP
rs1435056736 1371 dbSNP
rs1394321718 1372 dbSNP
rs1160423089 1373 dbSNP
rs1305824670 1373 dbSNP
rs1335588782 1373 dbSNP
rs1361082979 1373 dbSNP
rs1369328517 1373 dbSNP
rs138989248 1373 dbSNP
rs1403817144 1373 dbSNP
rs1451325523 1373 dbSNP
rs199522588 1373 dbSNP
rs878944882 1373 dbSNP
rs1491135493 1374 dbSNP
rs1180260272 1375 dbSNP
rs1192039697 1375 dbSNP
rs1221846228 1375 dbSNP
rs1250040491 1375 dbSNP
rs1263716571 1375 dbSNP
rs1351170060 1375 dbSNP
rs1354974931 1375 dbSNP
rs1380849934 1375 dbSNP
rs1417150050 1375 dbSNP
rs1473719712 1375 dbSNP
rs1487722840 1375 dbSNP
rs35587312 1375 dbSNP
rs377481199 1375 dbSNP
rs71451290 1375 dbSNP
rs1412033895 1377 dbSNP
rs1420639235 1380 dbSNP
rs932529109 1385 dbSNP
rs1228973898 1387 dbSNP
rs1294897224 1388 dbSNP
rs1316321161 1390 dbSNP
rs1447880628 1395 dbSNP
rs1258919476 1401 dbSNP
rs1460761335 1411 dbSNP
rs1207745388 1414 dbSNP
rs1254966543 1422 dbSNP
rs543930368 1423 dbSNP
rs921210911 1431 dbSNP
rs1185458650 1434 dbSNP
rs1420768159 1440 dbSNP
rs1468876754 1451 dbSNP
rs1478502045 1453 dbSNP
rs1170993014 1456 dbSNP
rs61994993 1456 dbSNP
rs965250282 1458 dbSNP
rs1174325054 1460 dbSNP
rs1449337013 1461 dbSNP
rs1309091134 1465 dbSNP
rs924682509 1474 dbSNP
rs774134037 1478 dbSNP
rs1323030571 1487 dbSNP
rs1217271450 1494 dbSNP
rs1280422924 1501 dbSNP
rs555009820 1527 dbSNP
rs1305012884 1528 dbSNP
rs1260890420 1536 dbSNP
rs1440945804 1545 dbSNP
rs1489023713 1556 dbSNP
rs1369566712 1558 dbSNP
rs1193738672 1559 dbSNP
rs1267747585 1564 dbSNP
rs1476797859 1579 dbSNP
rs1171214979 1588 dbSNP
rs1427758289 1593 dbSNP
rs1415372210 1594 dbSNP
rs1021552597 1602 dbSNP
rs1298818265 1603 dbSNP
rs1345153698 1612 dbSNP
rs1292340014 1617 dbSNP
rs1434518164 1618 dbSNP
rs118022841 1627 dbSNP
rs1020138554 1630 dbSNP
rs573111585 1646 dbSNP
rs1222987765 1648 dbSNP
rs1170102323 1652 dbSNP
rs1428080542 1654 dbSNP
rs1355692877 1655 dbSNP
rs1216708159 1656 dbSNP
rs552968561 1660 dbSNP
rs1317487878 1661 dbSNP
rs1200601461 1668 dbSNP
rs1174372616 1672 dbSNP
rs1003443591 1673 dbSNP
rs1178355504 1686 dbSNP
rs898031085 1694 dbSNP
rs1037167733 1696 dbSNP
rs1003996721 1708 dbSNP
rs1390165945 1712 dbSNP
rs1265334891 1713 dbSNP
rs888213354 1715 dbSNP
rs1350673144 1718 dbSNP
rs1441224653 1728 dbSNP
rs1048070269 1732 dbSNP
rs769167089 1739 dbSNP
rs1481574582 1740 dbSNP
rs932309808 1747 dbSNP
rs1353731231 1749 dbSNP
rs1211094841 1755 dbSNP
rs1290171160 1762 dbSNP
rs1436801782 1765 dbSNP
rs921148038 1765 dbSNP
rs183046804 1766 dbSNP
rs146155651 1771 dbSNP
rs1179858728 1774 dbSNP
rs576956389 1789 dbSNP
rs1471882362 1792 dbSNP
rs1282065753 1793 dbSNP
rs924492594 1794 dbSNP
rs977238058 1796 dbSNP
rs1465260474 1799 dbSNP
rs968749035 1819 dbSNP
rs914660943 1821 dbSNP
rs1447239897 1822 dbSNP
rs763463388 1830 dbSNP
rs1298550315 1831 dbSNP
rs749178205 1832 dbSNP
rs1246360779 1836 dbSNP
rs1284236420 1842 dbSNP
rs991414038 1845 dbSNP
rs1338373897 1851 dbSNP
rs1374613125 1854 dbSNP
rs1216463174 1859 dbSNP
rs556688273 1864 dbSNP
rs1459419731 1871 dbSNP
rs1036349085 1873 dbSNP
rs1003148438 1881 dbSNP
rs1189742057 1883 dbSNP
rs962506382 1883 dbSNP
rs1477519664 1884 dbSNP
rs1313771225 1886 dbSNP
rs1168886321 1887 dbSNP
rs1015074208 1891 dbSNP
rs557785714 1891 dbSNP
rs536755514 1892 dbSNP
rs1376061662 1895 dbSNP
rs1161299309 1898 dbSNP
rs1420824439 1906 dbSNP
rs1408568441 1908 dbSNP
rs1009617478 1914 dbSNP
rs1006414670 1922 dbSNP
rs1293619683 1925 dbSNP
rs1397581883 1925 dbSNP
rs1481976773 1927 dbSNP
rs1255729390 1929 dbSNP
rs888159474 1929 dbSNP
rs1048182028 1930 dbSNP
rs1211236683 1930 dbSNP
rs567776422 1935 dbSNP
rs1488037756 1936 dbSNP
rs1218277084 1941 dbSNP
rs996507740 1941 dbSNP
rs1482685844 1942 dbSNP
rs1253752529 1953 dbSNP
rs1240501936 1959 dbSNP
rs1318080619 1960 dbSNP
rs192049029 1968 dbSNP
rs1173154008 1979 dbSNP
rs1359805642 1982 dbSNP
rs1417331931 1984 dbSNP
rs1299424639 1988 dbSNP
rs1227072200 1989 dbSNP
rs1041343004 1990 dbSNP
rs943998223 1991 dbSNP
rs924541696 1992 dbSNP
rs1281682544 1994 dbSNP
rs1353533599 1999 dbSNP
rs1214588160 2002 dbSNP
rs1414405733 2004 dbSNP
rs1189879342 2005 dbSNP
rs1209514996 2005 dbSNP
rs1488646908 2005 dbSNP
rs1491403964 2005 dbSNP
rs201530637 2005 dbSNP
rs3081721 2005 dbSNP
rs869166266 2005 dbSNP
rs1491429622 2006 dbSNP
rs1290737171 2007 dbSNP
rs901927381 2008 dbSNP
rs1291490322 2009 dbSNP
rs1392361044 2011 dbSNP
rs1388892329 2012 dbSNP
rs79024977 2027 dbSNP
rs1376846040 2044 dbSNP
rs544979683 2045 dbSNP
rs947229641 2051 dbSNP
rs115214776 2055 dbSNP
rs1317661209 2057 dbSNP
rs991571260 2069 dbSNP
rs552584499 2074 dbSNP
rs1489547855 2075 dbSNP
rs1214129173 2087 dbSNP
rs532786854 2088 dbSNP
rs1456258262 2100 dbSNP
rs1180474605 2104 dbSNP
rs1380828523 2107 dbSNP
rs1422743153 2113 dbSNP
rs1162009419 2120 dbSNP
rs534767254 2128 dbSNP
rs1369870893 2129 dbSNP
rs1458056670 2141 dbSNP
rs563733125 2148 dbSNP
rs1400081959 2149 dbSNP
rs550356727 2155 dbSNP
rs1471565262 2156 dbSNP
rs1419763796 2164 dbSNP
rs1334015977 2174 dbSNP
rs1374611786 2175 dbSNP
rs1188317682 2179 dbSNP
rs1422901164 2186 dbSNP
rs1253595150 2187 dbSNP
rs1323754939 2193 dbSNP
rs1234185959 2202 dbSNP
rs928680225 2205 dbSNP
rs1315905771 2213 dbSNP
rs1206494830 2224 dbSNP
rs1485937157 2226 dbSNP
rs530230807 2236 dbSNP
rs1266924247 2240 dbSNP
rs1233391708 2252 dbSNP
rs1482863721 2257 dbSNP
rs1986032 2261 dbSNP
rs1337502563 2263 dbSNP
rs148061488 2264 dbSNP
rs1244461156 2266 dbSNP
rs1420999191 2276 dbSNP
rs1464401959 2279 dbSNP
rs1173186520 2282 dbSNP
rs984924745 2285 dbSNP
rs1298057035 2295 dbSNP
rs952225296 2298 dbSNP
rs1026732950 2299 dbSNP
rs996633247 2300 dbSNP
rs1415470652 2303 dbSNP
rs1277822056 2308 dbSNP
rs1318545813 2309 dbSNP
rs899484154 2312 dbSNP
rs1220273939 2314 dbSNP
rs1455588553 2315 dbSNP
rs1311371229 2317 dbSNP
rs1019253436 2320 dbSNP
rs1008310581 2322 dbSNP
rs1485748491 2323 dbSNP
rs1192225722 2324 dbSNP
rs1260591650 2328 dbSNP
rs143588424 2347 dbSNP
rs1165418443 2353 dbSNP
rs1457253591 2354 dbSNP
rs559641254 2356 dbSNP
rs1194957799 2364 dbSNP
rs947218292 2375 dbSNP
rs892994588 2380 dbSNP
rs1361392220 2381 dbSNP
rs1055791645 2385 dbSNP
rs34436523 2395 dbSNP
rs1186061707 2396 dbSNP
rs1338742919 2425 dbSNP
rs747615475 2426 dbSNP
rs538836279 2429 dbSNP
rs746369068 2437 dbSNP
rs1270961026 2444 dbSNP
rs928732666 2446 dbSNP
rs1274314835 2450 dbSNP
rs981429098 2452 dbSNP
rs1348414674 2453 dbSNP
rs781142341 2458 dbSNP
rs1283197677 2463 dbSNP
rs1354752913 2464 dbSNP
rs1245766530 2465 dbSNP
rs1477939043 2484 dbSNP
rs1189774448 2487 dbSNP
rs570300241 2491 dbSNP
rs189184704 2492 dbSNP
rs1158550649 2496 dbSNP
rs1358750510 2500 dbSNP
rs1402521462 2504 dbSNP
rs201881490 2506 dbSNP
rs3081717 2507 dbSNP
rs1029194853 2509 dbSNP
rs1295522869 2517 dbSNP
rs1443142387 2521 dbSNP
rs1371779603 2522 dbSNP
rs1371666565 2523 dbSNP
rs1239394237 2532 dbSNP
rs1306947629 2542 dbSNP
rs1355310273 2542 dbSNP
rs1326554035 2543 dbSNP
rs1386131033 2545 dbSNP
rs975330378 2546 dbSNP
rs963790764 2547 dbSNP
rs1255341054 2550 dbSNP
rs1469165650 2551 dbSNP
rs577022854 2552 dbSNP
rs80175518 2553 dbSNP
rs1471209495 2554 dbSNP
rs79858141 2555 dbSNP
rs746656230 2563 dbSNP
rs1389120613 2564 dbSNP
rs1403764441 2566 dbSNP
rs1166212164 2573 dbSNP
rs536817507 2577 dbSNP
rs1253061196 2578 dbSNP
rs868188177 2581 dbSNP
rs1329297016 2585 dbSNP
rs1378943958 2587 dbSNP
rs1442341218 2591 dbSNP
rs1198856812 2601 dbSNP
rs1353620955 2602 dbSNP
rs1229717604 2603 dbSNP
rs1020137801 2604 dbSNP
rs1253116180 2634 dbSNP
rs777920541 2636 dbSNP
rs1236894080 2637 dbSNP
rs1011475473 2638 dbSNP
rs1182644867 2641 dbSNP
rs140524863 2641 dbSNP
rs1055606254 2656 dbSNP
rs1167456716 2659 dbSNP
rs1418828742 2660 dbSNP
rs1464919941 2663 dbSNP
rs1168187916 2677 dbSNP
rs867155669 2682 dbSNP
rs907252782 2688 dbSNP
rs554223009 2691 dbSNP
rs940700115 2694 dbSNP
rs907901353 2697 dbSNP
rs1049329571 2698 dbSNP
rs1339376819 2702 dbSNP
rs1274332972 2705 dbSNP
rs1256502370 2707 dbSNP
rs1341879114 2715 dbSNP
rs930853834 2719 dbSNP
rs922181405 2726 dbSNP
rs1440825657 2752 dbSNP
rs1190085879 2769 dbSNP
rs183777068 2776 dbSNP
rs1329220478 2783 dbSNP
rs565536261 2787 dbSNP
rs1477590645 2790 dbSNP
rs966643825 2793 dbSNP
rs1475617670 2804 dbSNP
rs1330665902 2805 dbSNP
rs1410164955 2809 dbSNP
rs1436051968 2813 dbSNP
rs1312918451 2823 dbSNP
rs1359518574 2827 dbSNP
rs1484476084 2836 dbSNP
rs1397800565 2845 dbSNP
rs374505700 2852 dbSNP
rs1328627298 2856 dbSNP
rs12587233 2857 dbSNP
rs967003585 2869 dbSNP
rs1019876032 2872 dbSNP
rs1395160736 2877 dbSNP
rs1213152252 2881 dbSNP
rs1011212599 2882 dbSNP
rs1487986337 2897 dbSNP
rs1214810386 2898 dbSNP
rs1477337670 2912 dbSNP
rs538973470 2915 dbSNP
rs1366015514 2917 dbSNP
rs1197823150 2918 dbSNP
rs879477988 2930 dbSNP
rs570327824 2931 dbSNP
rs1455493032 2937 dbSNP
rs1183124498 2953 dbSNP
rs1379194626 2958 dbSNP
rs778756085 2960 dbSNP
rs1417311611 2962 dbSNP
rs957247554 2967 dbSNP
rs1034691370 2974 dbSNP
rs12885419 2975 dbSNP
rs1482961282 2977 dbSNP
rs1001368813 2978 dbSNP
rs1250046826 2981 dbSNP
rs1213373797 2985 dbSNP
rs11541026 2987 dbSNP
rs1369207691 2987 dbSNP
rs1045798115 2991 dbSNP
rs1005000840 3018 dbSNP
rs1236900582 3022 dbSNP
rs886536236 3034 dbSNP
rs1486296210 3042 dbSNP
rs1198755218 3043 dbSNP
rs1049067819 3051 dbSNP
rs930637907 3060 dbSNP
rs922200516 3063 dbSNP
rs1281256908 3065 dbSNP
rs1039731916 3066 dbSNP
rs944873234 3067 dbSNP
rs1349710573 3073 dbSNP
rs912074031 3078 dbSNP
rs978296081 3079 dbSNP
rs1457053843 3083 dbSNP
rs1161063706 3088 dbSNP
rs1392825284 3088 dbSNP
rs530292810 3090 dbSNP
rs1416255534 3092 dbSNP
rs967075482 3096 dbSNP
rs1376729682 3097 dbSNP
rs912983532 3103 dbSNP
rs1309178898 3105 dbSNP
rs1317566246 3106 dbSNP
rs989742764 3109 dbSNP
rs957071145 3111 dbSNP
rs1412291681 3113 dbSNP
rs561401198 3124 dbSNP
rs1214023974 3127 dbSNP
rs547903554 3135 dbSNP
rs1237496545 3140 dbSNP
rs1386431774 3161 dbSNP
rs1479594172 3165 dbSNP
rs528143984 3167 dbSNP
rs1001882054 3174 dbSNP
rs971243243 3178 dbSNP
rs75545906 3179 dbSNP
rs1185037875 3187 dbSNP
rs1004737578 3192 dbSNP
rs1463351745 3194 dbSNP
rs1472512438 3195 dbSNP
rs886488660 3197 dbSNP
rs1300379788 3200 dbSNP
rs192160391 3201 dbSNP
rs117048753 3207 dbSNP
rs994835018 3209 dbSNP
rs1357531400 3211 dbSNP
rs1233706448 3237 dbSNP
rs760217307 3246 dbSNP
rs900525002 3248 dbSNP
rs1039272713 3252 dbSNP
rs1251804962 3260 dbSNP
rs1185636796 3262 dbSNP
rs944922980 3264 dbSNP
rs145069103 3265 dbSNP
rs563214919 3267 dbSNP
rs1475300849 3269 dbSNP
rs1192449440 3272 dbSNP
rs1042493102 3283 dbSNP
rs945557927 3288 dbSNP
rs1284972355 3290 dbSNP
rs1209358746 3294 dbSNP
rs1328379493 3298 dbSNP
rs1173240621 3300 dbSNP
rs1355568348 3305 dbSNP
rs1465613576 3306 dbSNP
rs972201547 3314 dbSNP
rs912978327 3317 dbSNP
rs989898389 3321 dbSNP
rs1379575747 3326 dbSNP
rs543242532 3327 dbSNP
rs935664373 3333 dbSNP
rs549578739 3334 dbSNP
rs1283260949 3335 dbSNP
rs3742625 3340 dbSNP
rs1281898766 3342 dbSNP
rs1485692949 3346 dbSNP
rs1215534594 3352 dbSNP
rs1239994476 3360 dbSNP
rs1327687051 3363 dbSNP
rs1320634217 3376 dbSNP
rs554290215 3384 dbSNP
rs1485106668 3387 dbSNP
rs1457230196 3402 dbSNP
rs1420889640 3403 dbSNP
rs1454182904 3404 dbSNP
rs979807603 3408 dbSNP
rs540772172 3412 dbSNP
rs1397009927 3417 dbSNP
rs3742626 3420 dbSNP
rs1297832710 3422 dbSNP
rs983276060 3423 dbSNP
rs1432673160 3426 dbSNP
rs74245176 3433 dbSNP
rs1366613147 3434 dbSNP
rs1491044204 3435 dbSNP
rs60706999 3435 dbSNP
rs796787559 3435 dbSNP
rs199790013 3436 dbSNP
rs994950640 3438 dbSNP
rs868642779 3444 dbSNP
rs1413459879 3448 dbSNP
rs1180346204 3449 dbSNP
rs775341920 3458 dbSNP
rs1017998430 3463 dbSNP
rs1318309945 3464 dbSNP
rs1218413952 3467 dbSNP
rs1243106263 3469 dbSNP
rs141295287 3472 dbSNP
rs1192368388 3480 dbSNP
rs1255378650 3488 dbSNP
rs1242837346 3493 dbSNP
rs1158024743 3497 dbSNP
rs1406087780 3502 dbSNP
rs1402706404 3508 dbSNP
rs1187983519 3509 dbSNP
rs1464422487 3523 dbSNP
rs1438430546 3524 dbSNP
rs1327864811 3530 dbSNP
rs890666034 3531 dbSNP
rs145372984 3533 dbSNP
rs1215436450 3566 dbSNP
rs1277218403 3575 dbSNP
rs112161689 3578 dbSNP
rs1288800142 3595 dbSNP
rs1288696962 3604 dbSNP
rs1334625004 3617 dbSNP
rs1226325252 3620 dbSNP
rs945548105 3631 dbSNP
rs1341019357 3634 dbSNP
rs1469263887 3638 dbSNP
rs894002776 3667 dbSNP
rs1054120714 3669 dbSNP
rs556877738 3676 dbSNP
rs1297753005 3684 dbSNP
rs1471195557 3690 dbSNP
rs1178051502 3694 dbSNP
rs935722370 3700 dbSNP
rs1459685786 3704 dbSNP
rs1166779619 3724 dbSNP
rs377037306 3729 dbSNP
rs536886211 3732 dbSNP
rs1395156546 3734 dbSNP
rs1409355668 3751 dbSNP
rs1326734318 3759 dbSNP
rs1337084519 3765 dbSNP
rs927082428 3774 dbSNP
rs980136329 3775 dbSNP
rs567858078 3776 dbSNP
rs1437733254 3786 dbSNP
rs1231868075 3788 dbSNP
rs547925500 3796 dbSNP
rs1335866421 3797 dbSNP
rs527794190 3800 dbSNP
rs983389113 3805 dbSNP
rs950517238 3807 dbSNP
rs1439651214 3816 dbSNP
rs1163111517 3818 dbSNP
rs571683298 3823 dbSNP
rs1411917525 3828 dbSNP
rs1027458776 3833 dbSNP
rs1390989012 3838 dbSNP
rs973249974 3840 dbSNP
rs1447757796 3842 dbSNP
rs1190305344 3845 dbSNP
rs3829766 3848 dbSNP
rs531710842 3854 dbSNP
rs1398461584 3859 dbSNP
rs1410073118 3866 dbSNP
rs1311690980 3871 dbSNP
rs1488764267 3876 dbSNP
rs1245970497 3882 dbSNP
rs1009307704 3895 dbSNP
rs954774625 3896 dbSNP
rs1341500855 3900 dbSNP
rs563279705 3902 dbSNP
rs1342042196 3903 dbSNP
rs1215266607 3909 dbSNP
rs201254111 3912 dbSNP
rs1009805486 3919 dbSNP
rs112739425 3920 dbSNP
rs1213373837 3921 dbSNP
rs1190708263 3922 dbSNP
rs1258472923 3922 dbSNP
rs35358474 3922 dbSNP
rs1374744447 3923 dbSNP
rs529890975 3936 dbSNP
rs866943639 3941 dbSNP
rs1227146093 3944 dbSNP
rs770819938 3947 dbSNP
rs1053858839 3949 dbSNP
rs1339462106 3956 dbSNP
rs1392790889 3957 dbSNP
rs1304902536 3963 dbSNP
rs1313123019 3967 dbSNP
rs1436023356 3967 dbSNP
rs1383716182 3971 dbSNP
rs1002380073 3973 dbSNP
rs1316622079 3974 dbSNP
rs1367494712 3978 dbSNP
rs1292192413 3979 dbSNP
rs1444858199 3980 dbSNP
rs1371508893 3987 dbSNP
rs1307674754 3988 dbSNP
rs560756743 3991 dbSNP
rs1044191403 3999 dbSNP
rs1345890684 4001 dbSNP
rs1236513762 4007 dbSNP
rs1281345874 4012 dbSNP
rs1350163873 4014 dbSNP
rs1203591453 4018 dbSNP
rs1263632135 4020 dbSNP
rs1176862377 4026 dbSNP
rs1433749570 4032 dbSNP
rs1192991203 4037 dbSNP
rs1250993568 4043 dbSNP
rs1455193528 4044 dbSNP
rs369268115 4047 dbSNP
rs949731941 4052 dbSNP
rs916948444 4053 dbSNP
rs1252197768 4056 dbSNP
rs1397743777 4064 dbSNP
rs1047440973 4067 dbSNP
rs1387680204 4074 dbSNP
rs1458083752 4076 dbSNP
rs929181536 4076 dbSNP
rs920511678 4078 dbSNP
rs1204001904 4094 dbSNP
rs1302127679 4109 dbSNP
rs1335213911 4123 dbSNP
rs1237234790 4124 dbSNP
rs1481863945 4134 dbSNP
rs574762969 4136 dbSNP
rs964607047 4137 dbSNP
rs770936381 4139 dbSNP
rs139333323 4147 dbSNP
rs3813412 4148 dbSNP
rs1249258659 4154 dbSNP
rs1020885262 4186 dbSNP
rs1183612984 4194 dbSNP
rs1009542377 4197 dbSNP
rs1351493831 4200 dbSNP
rs958245081 4201 dbSNP
rs544712943 4202 dbSNP
rs1463510472 4214 dbSNP
rs576097186 4218 dbSNP
rs1395931296 4220 dbSNP
rs1408297436 4229 dbSNP
rs556944998 4240 dbSNP
rs1032564778 4241 dbSNP
rs1377479978 4250 dbSNP
rs1351293701 4254 dbSNP
rs772889685 4261 dbSNP
rs1291266433 4266 dbSNP
rs1002779862 4267 dbSNP
rs1250679478 4267 dbSNP
rs3841302 4267 dbSNP
rs549563167 4267 dbSNP
rs905382599 4278 dbSNP
rs1465633712 4283 dbSNP
rs536950453 4292 dbSNP
rs1474704303 4304 dbSNP
rs371715170 4306 dbSNP
rs1357449844 4312 dbSNP
rs1044524716 4314 dbSNP
rs1476381703 4320 dbSNP
rs1166124257 4335 dbSNP
rs1173883351 4336 dbSNP
rs1013975413 4337 dbSNP
rs895584221 4356 dbSNP
rs1412518565 4360 dbSNP
rs1371225158 4361 dbSNP
rs544239901 4363 dbSNP
rs567918642 4375 dbSNP
rs1357199278 4388 dbSNP
rs1228618942 4406 dbSNP
rs928962231 4406 dbSNP
rs1257877482 4410 dbSNP
rs1182037544 4413 dbSNP
rs920501872 4414 dbSNP
rs1274783980 4429 dbSNP
rs1485056213 4430 dbSNP
rs1037665745 4433 dbSNP
rs554087598 4433 dbSNP
rs534378627 4439 dbSNP
rs11541028 4441 dbSNP
rs571680661 4461 dbSNP
rs1427313767 4470 dbSNP
rs910417693 4476 dbSNP
rs1390943004 4477 dbSNP
rs1434174193 4482 dbSNP
rs1172022697 4483 dbSNP
rs987726014 4492 dbSNP
rs1267945422 4494 dbSNP
rs954770375 4498 dbSNP
rs1359563515 4506 dbSNP
rs1226908886 4507 dbSNP
rs777799310 4509 dbSNP
rs772338396 4518 dbSNP
rs988068906 4527 dbSNP
rs11541029 4550 dbSNP
rs958066535 4550 dbSNP
rs1377072254 4556 dbSNP
rs1290701433 4560 dbSNP
rs1241939888 4561 dbSNP
rs1485097461 4565 dbSNP
rs1032987929 4568 dbSNP
rs981074735 4570 dbSNP
rs1453876784 4572 dbSNP
rs1191787261 4580 dbSNP
rs970057508 4588 dbSNP
rs748313332 4590 dbSNP
rs1014171822 4591 dbSNP
rs182132150 4594 dbSNP
rs1343274813 4597 dbSNP
rs1455098536 4598 dbSNP
rs1158287089 4609 dbSNP
rs531637242 4610 dbSNP
rs1455467133 4613 dbSNP
rs1370101911 4615 dbSNP
rs1438101750 4630 dbSNP
rs1369924622 4633 dbSNP
rs1026100676 4634 dbSNP
rs1367661789 4641 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000337537.3 | 3UTR | UAACAUCCUCCUCUGGAUAACUUGACUGUAAUUUAACAUCUUUUUCUUUUGCACAUCUUCCUGAGUUGAAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla 0.883 3.2e-5 0.764 1.2e-3 13 Click to see details
GSE27834 Pluripotent stem cells -0.542 1.5e-2 -0.524 1.9e-2 16 Click to see details
GSE38226 Liver fibrosis -0.287 1.0e-1 -0.216 1.7e-1 21 Click to see details
GSE26953 Aortic valvular endothelial cells -0.263 1.1e-1 -0.152 2.4e-1 24 Click to see details
GSE32688 Pancreatic cancer -0.201 1.3e-1 -0.095 3.0e-1 32 Click to see details
GSE21687 Ependynoma primary tumors 0.13 1.5e-1 0.225 3.7e-2 64 Click to see details
GSE42095 Differentiated embryonic stem cells 0.213 1.6e-1 0.254 1.2e-1 23 Click to see details
GSE17498 Multiple myeloma -0.144 1.9e-1 -0.192 1.2e-1 40 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.206 1.9e-1 -0.072 3.8e-1 20 Click to see details
GSE14794 Lymphoblastoid cells -0.078 2.3e-1 -0.018 4.3e-1 90 Click to see details
GSE19350 CNS germ cell tumors -0.163 3.1e-1 -0.287 1.8e-1 12 Click to see details
GSE21849 B cell lymphoma -0.098 3.1e-1 0.281 7.0e-2 29 Click to see details
GSE17306 Multiple myeloma 0.066 3.3e-1 0.443 7.2e-4 49 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.094 3.3e-1 0.184 1.9e-1 25 Click to see details
GSE28544 Breast cancer 0.066 3.8e-1 0.046 4.2e-1 24 Click to see details
GSE28544 Breast cancer 0.066 3.8e-1 0.046 4.2e-1 24 Click to see details
GSE28544 Breast cancer 0.066 3.8e-1 0.046 4.2e-1 24 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
HNSC 0.504 0.1 0.548 0.08 8 Click to see details
BRCA 0.407 0.12 -0.030 0.47 10 Click to see details
LIHC -0.571 0.16 0.000 0.5 5 Click to see details
LUSC -0.669 0.17 -0.400 0.3 4 Click to see details
BLCA -0.372 0.31 -0.400 0.3 4 Click to see details
PRAD -0.029 0.49 -0.400 0.3 4 Click to see details
PRAD -0.029 0.49 -0.400 0.3 4 Click to see details
PRAD -0.029 0.49 -0.400 0.3 4 Click to see details
PRAD -0.029 0.49 -0.400 0.3 4 Click to see details
PRAD -0.029 0.49 -0.400 0.3 4 Click to see details
PRAD -0.029 0.49 -0.400 0.3 4 Click to see details
115 hsa-miR-520a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT092732 SETD5 SET domain containing 5 2 4
MIRT168595 HMGA1 high mobility group AT-hook 1 2 4
MIRT232084 CCSAP centriole, cilia and spindle associated protein 2 2
MIRT252430 MIDN midnolin 2 4
MIRT294600 ZNF460 zinc finger protein 460 2 2
MIRT343114 IGF1R insulin like growth factor 1 receptor 2 2
MIRT441904 SEPN1 selenoprotein N 2 2
MIRT443233 ALG8 ALG8, alpha-1,3-glucosyltransferase 2 2
MIRT446250 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT448001 GPR63 G protein-coupled receptor 63 2 2
MIRT451560 CIAPIN1 cytokine induced apoptosis inhibitor 1 2 2
MIRT455285 BCL2L1 BCL2 like 1 2 2
MIRT456170 ZDHHC6 zinc finger DHHC-type containing 6 2 2
MIRT456679 LDB1 LIM domain binding 1 2 2
MIRT458206 FOXL2 forkhead box L2 2 2
MIRT461267 COX10 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 2 2
MIRT461683 ZNF426 zinc finger protein 426 2 2
MIRT462656 HMOX1 heme oxygenase 1 2 4
MIRT464368 URM1 ubiquitin related modifier 1 2 2
MIRT468138 SH3BP4 SH3 domain binding protein 4 2 2
MIRT468234 SGK1 serum/glucocorticoid regulated kinase 1 2 2
MIRT470357 PPP2R5E protein phosphatase 2 regulatory subunit B'epsilon 2 2
MIRT472039 NPAT nuclear protein, coactivator of histone transcription 2 2
MIRT475941 GXYLT1 glucoside xylosyltransferase 1 2 2
MIRT477880 DYNLL2 dynein light chain LC8-type 2 2 2
MIRT480419 C17orf85 nuclear cap binding subunit 3 2 2
MIRT482642 RPL18A ribosomal protein L18a 2 2
MIRT485666 CDC25B cell division cycle 25B 2 2
MIRT485740 CALCR calcitonin receptor 2 2
MIRT488906 TSTD2 thiosulfate sulfurtransferase like domain containing 2 2 6
MIRT490412 NRXN3 neurexin 3 2 2
MIRT494726 ARHGAP1 Rho GTPase activating protein 1 2 6
MIRT495957 TBC1D19 TBC1 domain family member 19 2 2
MIRT498087 SEMA7A semaphorin 7A (John Milton Hagen blood group) 2 2
MIRT507449 EIF6 eukaryotic translation initiation factor 6 2 2
MIRT522992 INPP4A inositol polyphosphate-4-phosphatase type I A 2 4
MIRT526008 RBM4B RNA binding motif protein 4B 2 2
MIRT527693 IL17REL interleukin 17 receptor E like 2 2
MIRT528202 NELFE negative elongation factor complex member E 2 2
MIRT529123 HOMEZ homeobox and leucine zipper encoding 2 2
MIRT529484 TPD52L3 tumor protein D52 like 3 2 2
MIRT530760 ZNF582 zinc finger protein 582 2 2
MIRT531930 IL12RB2 interleukin 12 receptor subunit beta 2 2 2
MIRT532347 PLEK pleckstrin 2 2
MIRT532819 ZNF827 zinc finger protein 827 2 2
MIRT533262 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT533518 TRIM13 tripartite motif containing 13 2 2
MIRT534279 SLC12A7 solute carrier family 12 member 7 2 2
MIRT534483 SAR1B secretion associated Ras related GTPase 1B 2 2
MIRT538555 CELF1 CUGBP Elav-like family member 1 2 4
MIRT538801 C2CD5 C2 calcium dependent domain containing 5 2 2
MIRT553759 TAOK1 TAO kinase 1 2 2
MIRT556035 MXD1 MAX dimerization protein 1 2 2
MIRT557541 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT562451 CSDE1 cold shock domain containing E1 2 2
MIRT563686 RPS26 ribosomal protein S26 2 2
MIRT568249 BTF3L4 basic transcription factor 3 like 4 2 2
MIRT568422 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT574053 PROSC pyridoxal phosphate binding protein 2 2
MIRT606825 APBB2 amyloid beta precursor protein binding family B member 2 2 2
MIRT609585 GPM6B glycoprotein M6B 2 2
MIRT609680 TMEM213 transmembrane protein 213 2 2
MIRT611223 ZNF274 zinc finger protein 274 2 2
MIRT612585 SYNGAP1 synaptic Ras GTPase activating protein 1 2 4
MIRT613585 MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 2 2
MIRT614396 C11orf45 chromosome 11 open reading frame 45 2 2
MIRT615562 JPH2 junctophilin 2 2 2
MIRT615852 RASGRP1 RAS guanyl releasing protein 1 2 2
MIRT615934 MAP1LC3B microtubule associated protein 1 light chain 3 beta 2 2
MIRT617635 RXRA retinoid X receptor alpha 2 2
MIRT618058 PCDH19 protocadherin 19 2 2
MIRT618747 CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2 2
MIRT623739 GRIN2B glutamate ionotropic receptor NMDA type subunit 2B 2 2
MIRT629609 NOL10 nucleolar protein 10 2 2
MIRT635219 CD59 CD59 molecule (CD59 blood group) 2 2
MIRT638035 SHPK sedoheptulokinase 2 2
MIRT638545 KIAA1549 KIAA1549 2 2
MIRT645853 AFF2 AF4/FMR2 family member 2 2 2
MIRT646023 S100A7A S100 calcium binding protein A7A 2 2
MIRT646562 ALDH5A1 aldehyde dehydrogenase 5 family member A1 2 2
MIRT646735 FADS1 fatty acid desaturase 1 2 2
MIRT652853 TACC1 transforming acidic coiled-coil containing protein 1 2 2
MIRT654754 PRKCB protein kinase C beta 2 2
MIRT655238 PEX26 peroxisomal biogenesis factor 26 2 2
MIRT655627 ONECUT1 one cut homeobox 1 2 2
MIRT655892 NEK9 NIMA related kinase 9 2 2
MIRT656184 MON1B MON1 homolog B, secretory trafficking associated 2 2
MIRT656551 LZIC leucine zipper and CTNNBIP1 domain containing 2 2
MIRT657743 GNG12 G protein subunit gamma 12 2 2
MIRT659981 C2CD2L C2CD2 like 2 2
MIRT660824 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT663511 AGMO alkylglycerol monooxygenase 2 2
MIRT666613 REEP2 receptor accessory protein 2 2 2
MIRT668266 FOXO3 forkhead box O3 2 2
MIRT669395 BACE2 beta-site APP-cleaving enzyme 2 2 2
MIRT669512 ARHGAP26 Rho GTPase activating protein 26 2 2
MIRT678895 TTLL12 tubulin tyrosine ligase like 12 2 2
MIRT685122 ADAT1 adenosine deaminase, tRNA specific 1 2 2
MIRT685674 PSMB7 proteasome subunit beta 7 2 2
MIRT690647 RPF2 ribosome production factor 2 homolog 2 2
MIRT697114 OTUD5 OTU deubiquitinase 5 2 2
MIRT697742 USP5 ubiquitin specific peptidase 5 2 2
MIRT698584 TEX261 testis expressed 261 2 2
MIRT700075 RNF38 ring finger protein 38 2 2
MIRT709340 ZNF35 zinc finger protein 35 2 2
MIRT711071 NLGN2 neuroligin 2 2 2
MIRT714634 TM4SF18 transmembrane 4 L six family member 18 2 2
MIRT715421 SPOPL speckle type BTB/POZ protein like 2 2
MIRT718663 HNF4A hepatocyte nuclear factor 4 alpha 2 2
MIRT718931 TRIM66 tripartite motif containing 66 2 2
MIRT720640 ELF5 E74 like ETS transcription factor 5 2 2
MIRT720788 PRKRIP1 PRKR interacting protein 1 2 2
MIRT721289 TRABD2A TraB domain containing 2A 2 2
MIRT722893 LRRC20 leucine rich repeat containing 20 2 2
MIRT724307 KCNH1 potassium voltage-gated channel subfamily H member 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-520a-5p Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-520a-5p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375)
hsa-miR-520a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-520a-5p Paclitaxel 36314 NSC125973 approved resistant cell line (HS578T)
hsa-miR-520a-5p Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-520a-5p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-520a-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-520a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-520a-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide sensitive cell line (Bads-200)

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