pre-miRNA Information
pre-miRNA hsa-mir-4747   
Genomic Coordinates chr19: 4932687 - 4932740
Description Homo sapiens miR-4747 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4747-5p
Sequence 1| AGGGAAGGAGGCUUGGUCUUAG |22
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs560927363 4 dbSNP
rs1471226927 10 dbSNP
rs763137545 12 dbSNP
rs767337154 15 dbSNP
rs775298039 16 dbSNP
rs760472311 19 dbSNP
rs1207950315 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PPP1R16B   
Synonyms ANKRD4, TIMAP
Description protein phosphatase 1 regulatory subunit 16B
Transcript NM_001172735   
Other Transcripts NM_015568   
Expression
Putative miRNA Targets on PPP1R16B
3'UTR of PPP1R16B
(miRNA target sites are highlighted)
>PPP1R16B|NM_001172735|3'UTR
   1 TCTCCGTGTGATGGAGGAGGGAGATGCCTGGGGAGGGGCTCCTGGAATCCAGGCCAGCCCAACAGCCCTGGCTGGGGAGG
  81 TGTCAGGGCAGCTGGGGAGAGGTGGGCTCTGCTTTTCAGAGGAACTCAGACCCCAGCCCTCAGCTGGCTGCCCATAGCAT
 161 CCCATGTCCCACGTCCCGTGGTTCTGCTTCCTGCTGCATCGTCTGCCATCTGACACAAGGCCTGTCGTGGCCTCCTGGTT
 241 CACTCTGCTGTCTGATCTTGGGAGGGTGGGCTTGAGATCCCAGCTCTATTCTTGGTATAAAGGCTTCTCCGGATCAGTAC
 321 ATGCATGTCACATTAACACACACACACACACACATATACACACACACACAAGCTCGATCAGTGTGTGTAGGAATGACATA
 401 CCTGGGCTCAGGGGAAGCAAGGGGGCTTAGAATTTGTGGGGTATTCCCAAAAGGATGGAAGTTAAGACTCAGAGTCTCAT
 481 TACCACTGCCAATGTGGTTTTAGCAGGGGAGGGGACCTGCTAAGCTGAGACCCATAGTCCTGCTCAGAGTTATCCCAAAG
 561 TCTGAGCCACCAGCCACACCTGACAGGGGTGAGAAGTCCTCGCTGTGTTCAGAGGGAGCCAGGAATCTACATGGGTAGAT
 641 GAGATAGACACAGACCTGCTCCCCGCAGCCTTGTTGAGAGCCACACTTCTGCCCATGCCAGGAGCCAGCTGTGTGACCAT
 721 CCAGGGGTGGAGGGGGAAAACCAGGCAATTTCGTTCCTGGAATCAACCAAATCATGTTTTCCTCTTGGATGGAAGTGTCA
 801 AAGGCAGAAGGGTGTGGGAGGGGGACAAGGTCAGTATTTACCAAAGTGTATCTGATTTTAAAAATTCCTTTAGTCTGTAA
 881 AACTCCTAGAGGGAGGGAGGTAACTGAATTCACTTCTTTTTGTGGATCGTATCAAGGTCACTGGGTTTTACTGGCTGGTG
 961 CTGGGAAAATGAAGCTAAGTGAGGAGCTTCCATTGGAATGCTTTTCCAGGGAGAGAGGCCAGTTAATTTAAAAAAAACAG
1041 TCGCTAGTTAACAGCGACAGAGCCCAGCACCCTGGGGTCTTTGTGAATATCCAGACTGTTTCAGCCCAGCCCATCTCAGC
1121 CAACCCTCCTTAGACTGAGCTGTCAGAGCAAGCAATTAGGGGCCAGCCTGCCTCCACCTCCCACCCCCTTCCACCTCCAT
1201 CAGTCATGTGTGCAGAGTCAGTGCTCGGGATCCCGGGCCCAGCTTTTGCCTTTTTGGGGATGCTTGGTGAGACAGATTTG
1281 CCAGTCAGCCCTTTTGAGTTCCCGCCTCACCCAGGGGCTCCCAGCCTGCACTTGCAGGAGTGGTGATGCCCCAAGTCTGC
1361 GAATCCAGGGTGCACGTGGTCAATATCCCCTCCTGCATTCAGGAGAGCCATGGTAGGGCTAGAGTTGGGTCTTGCCCAGC
1441 CCTGCAGTTTCATAGTCCCAGCCTTCCTGGTGCTGGGGAGGGAGGACTGTGAATGGCTGTTCTCCCCTCACTGCTGAGTC
1521 TCCCAGGACCCCCTTTGGAGATGCCCATGGCATGGGCACTGCCCACAGGCTCAGCCAGAACCTCTTGGTGTACCCGATAA
1601 GCTGCAGGTTATCCCTTGCTCTGTGCGCCTTTTATTTGTCCTTAAACTACCTCCTTAGAGCTCTGAAGGGGTCTCCTAGT
1681 TCCAGATTTTAATTTGGGGAACAGATCTGGGTTCTTTTTAACCCTCTTCTTTCTCAGTCTATGAGAAACTTGCCCTGAGG
1761 GGCACCTGGGCTAGGGGCTTGGGACTGGAAGACCATCCCCGCCTTGTGCCACAACTTTGGTCATGGGATCTGCTCTTTGT
1841 CATTCTTAGCCCCCTACTGTGGCCCCCATAGCCCCATAACCCAGAGAGGGAGCTGGACTTCAGGGAGCCTGAGTGATGCT
1921 TTCCCAGGAGCAGGGCAGCTGGCTGGACCAGAAAGTAGAGGGCCCATGGGAGTGACTGCACCCTTGGTGGCTGCTGGAAG
2001 GGGAGAGGTTCTCAGCATCAGGCCACCTCCACCCCAATGCCAGGATAGATGTATTCTAGAGTAGGGGTGGAGGCGGCCCA
2081 GGAGGCTGAAGACAGGTGCACAGATGCTTCCCACGACCTTGCCATTTGGGGTGGGCTCTTCAACATCTCAGGCTGTGGCT
2161 GGAACAGGACAGGATGATCTAAAACACACGTACCATTGGCTGTAAAACAGTATGAGCCCAGACTGACGCTGAAATCCCTC
2241 ATGAGCCAACCTTAGCTACAAGGTAGGGAGTTCTGAGGGAAGCCGCGTGCTCCTCAGGAGAGAGCTGTTTAGGTTTTCCG
2321 ATCTTTTTGCTCAGGGGCCAAACACTGAAGGCACGTACTGCCCAACCCACTGAGCGCCTGAGGCCATTCCCTCCTTTTCC
2401 GCATGCCTCCTGCCTCCTGGGCTATTCCTCTCCACCCAGAAGGCTGGGAATCCCAGCTGATTCCCTGACAGGAGCCGACT
2481 TCACACACAGGTGACTCTCAGGCATTGGCTCATGTTTTCAGCCAGGGATAAACCATCCCTTCTTGGGGCTTTAAGTCCCT
2561 GGGGAGCTTTCCCTGTAGGTCTCCTGGGTGTTGAGAGACAAGTTGGAGACCAACCTCCAATGAATGAGCCGCGGTCATTC
2641 ATTAATTCACTCACGTAATTTACTGAGTAGCTGCAACATGCCAGCCTCTACGTTAGGTTCTGCGGATAAAGGAGGAATAA
2721 GACAGAGTCAGGAGAACTGTTCCTTGTGGTTTCCGTCCCTTGGGGACCACAGGCATCAGCAGTCCCATTCAAGTCACCTG
2801 AGGCAAAGTGTCTGCATCTTCGTCCAGCGACCCTTTGCTTTTCGGCTCCTAGAATCCTTAGAGTCTGAATTCCTTTAGCT
2881 GGGAACAGCTGTCATGGTCACCCCTGGATAACATTTGCCACCAAGTATAGATGCTGGATCTTGGGTTCCAGGCAGACATC
2961 ATCCAGGTCCATCTGGAACTTTCAGTGATAGCTGCCTTCAGCCAGCATCTTTGGGGGACTCTATAATAGCAGCTTGAGAT
3041 CAGTGTCTAGAAGACTGTTCTGCAATTTGCTGCCAAATGCATCTCAGGTTTTTAAAGTCATTGTTTCTTGCTCATGGTGG
3121 CTCATTTATTACATAGTCCCCTCACCCCACTAATGGATAATGGGAGGAAAAGTTGCTGCTTCCTTCAGCATCAAAGCCTT
3201 TCCTTGGGAATCTGCCTCCCTCCATGGCAGGGGTGGATTCGGGAGCTGGGAGTAACCAGGCAAAGTCAACCAGATGCCTA
3281 GCTCCTGCTGAGACCCAGGTCCTATGGCAGCTCCTCATTAGATTAAAGGAGACCACTTCCAAAGCAGGTGCTGCATGGCT
3361 CACCATCATATGCCCCAAACAACTGAAAGTTGGCGGTTATCACCAGACTGTGAGTTTCTGGCAAGTAGCTTGGGGAAGCT
3441 GAATAAACTCTAGGCCCAGGGCTACTAAAGACTTCAGGATAGAATTCTCCATCAAATATACAGCATAAGTAAAACTGCTC
3521 TGCACTGTTTAATCCATTTCCAAGGGGCTTAGAAAAGCTAACAAGGGTGTGTCCCCTGTCCTGCCCCACCGGTTTGCTGG
3601 CTTTGTAATAACATAAGACCATTGTGGTTGTTGGTGTCAGATACCTTCCCATCCTGAGCTCTCTCACCTACCTGCTCTCT
3681 CTCCTAGAGCAGGATACTGGGGTACTTTTAAGAAGGGTGCTCCTTTTAAGATGCCCAGAAAAGCTGTATTTAACTCTTGC
3761 TATTTGTAACTTGGGGATGGTCTCCCCTGCCCCAGGGCACATAAGAGCAAAGGCTCCAATGGTCAGTGGATGACTCTGCA
3841 AAAGTGACCCCCTGTGCCAGAAGCTATAGCCCTCTCCCCAACAGGTCTCTCTTGTTGGCCAGAGGGCCTGCTTCCCATGG
3921 GCATTGCAAGTGCCACCGTGCGGGGCCTGGCTCTGCACACCCAGGAAAAGTCTGCAGACCCCCAGCCCTCCGCAATAATT
4001 CACCAGACCAGAAGCCACTGGTGTACAGAGAACACTTAAAAAAATGTATTTTATGTGAAAAAAAATTAAAACTCTGTATA
4081 CTGTATCAGCAGCTTTGTGTAAAAATGGCAATCAAGAGAGTCTAATATATTTAAAACTTTTTTAAAAAAAATCTTCGCAG
4161 ATCTTTGATATCGTACTGAGGTAACTTCCACGTAGCCCCTTGCCACGCGGCACCGGTGGGCCTTGGGTCCAAAACTGTGG
4241 CTCAGCCACATCCCAAAGGGGGCACATGTCCCTGGAGTTGCTTCCAGCTGCCAAGGCCTGTGACAGAATTCGCTGTTAAG
4321 AGTTTTTAATTAAAATTATTAAATTCCTTTTAATAACAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gauucugguUCGGAGGAAGGGa 5'
                   || : ||||||| 
Target 5' gttggtgtcAGATACCTTCCCa 3'
3630 - 3651 145.00 -14.40
2
miRNA  3' gaUUCUGGUUCG--GAGGAAGGGa 5'
            :|| |::||:  : |:||||| 
Target 5' ggGAGCCTGAGTGATGCTTTCCCa 3'
1903 - 1926 138.00 -13.60
3
miRNA  3' gauuCUGGU---UCGGAGGAAGGGa 5'
              |:|||   :|||| |||||| 
Target 5' tgttGGCCAGAGGGCCTGCTTCCCa 3'
3893 - 3917 138.00 -23.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31509908 5 COSMIC
COSN26990098 6 COSMIC
COSN30468744 6 COSMIC
COSN30166131 7 COSMIC
COSN31491248 18 COSMIC
COSN30491356 21 COSMIC
COSN30473730 22 COSMIC
COSN26990099 35 COSMIC
COSN15655107 66 COSMIC
COSN30451191 75 COSMIC
COSN24838282 128 COSMIC
COSN21594318 295 COSMIC
COSN20079642 354 COSMIC
COSN30105139 356 COSMIC
COSN31487111 360 COSMIC
COSN31584972 376 COSMIC
COSN30545400 402 COSMIC
COSN31550736 437 COSMIC
COSN17260916 440 COSMIC
COSN5970074 489 COSMIC
COSN26556658 497 COSMIC
COSN20093767 548 COSMIC
COSN26552462 561 COSMIC
COSN31483352 602 COSMIC
COSN31588994 623 COSMIC
COSN31571981 629 COSMIC
COSN21479271 633 COSMIC
COSN15868691 768 COSMIC
COSN5970075 1008 COSMIC
COSN1871256 1113 COSMIC
COSN23704038 1334 COSMIC
COSN8610933 1404 COSMIC
COSN31569261 1446 COSMIC
COSN1871257 1461 COSMIC
COSN23598410 1627 COSMIC
COSN31553642 1628 COSMIC
COSN31608227 1689 COSMIC
COSN31590323 1746 COSMIC
COSN28259766 1751 COSMIC
COSN31480018 1776 COSMIC
COSN7090914 1863 COSMIC
COSN25622794 1974 COSMIC
COSN22742228 2202 COSMIC
COSN23229410 2356 COSMIC
COSN5443600 2386 COSMIC
COSN21895823 2760 COSMIC
COSN20832356 2900 COSMIC
COSN28676480 3627 COSMIC
COSN26565160 3637 COSMIC
COSN24187106 3731 COSMIC
COSN31544977 3799 COSMIC
COSN28706439 3822 COSMIC
COSN22428381 3832 COSMIC
COSN31518788 3850 COSMIC
COSN31561711 3872 COSMIC
COSN31591625 3908 COSMIC
COSN31536198 3932 COSMIC
COSN22096079 3939 COSMIC
COSN31541361 3943 COSMIC
COSN31544272 3971 COSMIC
COSN31490476 4065 COSMIC
COSN31582853 4106 COSMIC
COSN31520096 4119 COSMIC
COSN17038267 4144 COSMIC
COSN31483310 4145 COSMIC
COSN31546970 4154 COSMIC
COSN31575663 4198 COSMIC
COSN19659358 4288 COSMIC
COSN1871258 4297 COSMIC
COSN30216635 4355 COSMIC
rs4812336 66 GWAS
rs10392 3627 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1251878981 3 dbSNP
rs370577250 6 dbSNP
rs750762635 7 dbSNP
rs1369994288 13 dbSNP
rs995438762 14 dbSNP
rs1054938469 22 dbSNP
rs896410449 26 dbSNP
rs780730725 27 dbSNP
rs1388311064 28 dbSNP
rs1191502693 30 dbSNP
rs1431531680 34 dbSNP
rs747496859 35 dbSNP
rs1013468966 39 dbSNP
rs755727509 40 dbSNP
rs868834295 42 dbSNP
rs1396255680 45 dbSNP
rs1342637472 51 dbSNP
rs1356459910 58 dbSNP
rs970058137 63 dbSNP
rs4812336 66 dbSNP
rs1036390072 67 dbSNP
rs776641035 68 dbSNP
rs1168566234 69 dbSNP
rs575554820 72 dbSNP
rs1391710407 73 dbSNP
rs1371407217 75 dbSNP
rs1406567547 76 dbSNP
rs765711877 78 dbSNP
rs1189826926 81 dbSNP
rs1475669698 83 dbSNP
rs1032494416 86 dbSNP
rs1323843553 93 dbSNP
rs1344187516 102 dbSNP
rs1195171754 110 dbSNP
rs964466001 119 dbSNP
rs1266733333 131 dbSNP
rs1279933334 143 dbSNP
rs976007313 144 dbSNP
rs1354483339 149 dbSNP
rs913620788 155 dbSNP
rs775943618 173 dbSNP
rs979198869 174 dbSNP
rs1391350487 177 dbSNP
rs1394359470 178 dbSNP
rs1165120227 179 dbSNP
rs920928594 189 dbSNP
rs112666538 195 dbSNP
rs1050989885 196 dbSNP
rs1162513520 197 dbSNP
rs1473417368 201 dbSNP
rs912472289 202 dbSNP
rs1180950416 207 dbSNP
rs1436034299 209 dbSNP
rs1268814591 216 dbSNP
rs940003936 227 dbSNP
rs149794411 228 dbSNP
rs1037285548 242 dbSNP
rs1264414880 255 dbSNP
rs1353234053 261 dbSNP
rs898358286 263 dbSNP
rs995533163 265 dbSNP
rs1238930738 270 dbSNP
rs1044502052 271 dbSNP
rs1334551158 277 dbSNP
rs1325602350 282 dbSNP
rs905866722 283 dbSNP
rs577698834 295 dbSNP
rs141414039 299 dbSNP
rs751875564 299 dbSNP
rs751914994 299 dbSNP
rs765439968 299 dbSNP
rs896284881 303 dbSNP
rs763407533 311 dbSNP
rs1035921668 312 dbSNP
rs1420599345 316 dbSNP
rs144754784 320 dbSNP
rs560309980 323 dbSNP
rs547929598 328 dbSNP
rs573896088 332 dbSNP
rs141057776 336 dbSNP
rs1491576288 336 dbSNP
rs35869936 336 dbSNP
rs758171761 336 dbSNP
rs1406603707 337 dbSNP
rs902210185 342 dbSNP
rs1285368415 344 dbSNP
rs1223638850 354 dbSNP
rs397756011 355 dbSNP
rs1022192408 356 dbSNP
rs1000547043 358 dbSNP
rs1360978183 358 dbSNP
rs1370274261 358 dbSNP
rs1433116693 360 dbSNP
rs968913652 361 dbSNP
rs1346062179 362 dbSNP
rs979167860 376 dbSNP
rs1413902495 377 dbSNP
rs1031985169 387 dbSNP
rs921023301 405 dbSNP
rs1453759908 409 dbSNP
rs1311021975 423 dbSNP
rs900253346 426 dbSNP
rs1475531141 428 dbSNP
rs543262399 439 dbSNP
rs1241229709 447 dbSNP
rs953655438 454 dbSNP
rs995907755 456 dbSNP
rs1445583279 459 dbSNP
rs1245611590 461 dbSNP
rs367865948 462 dbSNP
rs1347839752 470 dbSNP
rs1278253391 471 dbSNP
rs986890462 472 dbSNP
rs912453392 485 dbSNP
rs955535181 486 dbSNP
rs1269752913 488 dbSNP
rs1286969236 489 dbSNP
rs1428900132 491 dbSNP
rs1357090411 492 dbSNP
rs1313306809 493 dbSNP
rs563054266 494 dbSNP
rs113338430 507 dbSNP
rs148507436 510 dbSNP
rs1209114828 514 dbSNP
rs1373623995 525 dbSNP
rs761372195 534 dbSNP
rs1409975663 535 dbSNP
rs1418183729 540 dbSNP
rs530143176 548 dbSNP
rs1473592422 561 dbSNP
rs1032209055 570 dbSNP
rs1181704503 575 dbSNP
rs961578311 579 dbSNP
rs749961756 580 dbSNP
rs1189154045 585 dbSNP
rs1468130990 588 dbSNP
rs45562136 590 dbSNP
rs1380482168 598 dbSNP
rs931183609 602 dbSNP
rs919898161 603 dbSNP
rs1272398490 607 dbSNP
rs1213000167 616 dbSNP
rs533054524 622 dbSNP
rs1337291018 633 dbSNP
rs1044427070 634 dbSNP
rs190280707 649 dbSNP
rs1353337625 651 dbSNP
rs1002798102 652 dbSNP
rs1396591983 655 dbSNP
rs144205123 656 dbSNP
rs1442865189 657 dbSNP
rs1334097975 658 dbSNP
rs192683898 665 dbSNP
rs1010901932 666 dbSNP
rs1021911086 675 dbSNP
rs968839292 677 dbSNP
rs1418193370 681 dbSNP
rs1166095991 694 dbSNP
rs996348469 695 dbSNP
rs549227157 696 dbSNP
rs1028053010 697 dbSNP
rs1255859547 705 dbSNP
rs1179407948 709 dbSNP
rs185079646 714 dbSNP
rs953789024 721 dbSNP
rs986597277 722 dbSNP
rs1232365846 723 dbSNP
rs1019681158 725 dbSNP
rs1273975940 727 dbSNP
rs936536378 732 dbSNP
rs1332348280 733 dbSNP
rs1308918275 735 dbSNP
rs1195773197 741 dbSNP
rs1224242847 742 dbSNP
rs1372584552 743 dbSNP
rs538173748 745 dbSNP
rs1295932667 753 dbSNP
rs1442554308 754 dbSNP
rs1248987796 761 dbSNP
rs1324729815 766 dbSNP
rs1459564516 767 dbSNP
rs557856608 789 dbSNP
rs961111384 791 dbSNP
rs577661675 793 dbSNP
rs879690174 796 dbSNP
rs752585321 807 dbSNP
rs1238416006 811 dbSNP
rs1420195508 816 dbSNP
rs377246061 817 dbSNP
rs546857268 820 dbSNP
rs931111794 820 dbSNP
rs979916556 824 dbSNP
rs927157159 825 dbSNP
rs1253730182 849 dbSNP
rs1191340404 861 dbSNP
rs1379199482 866 dbSNP
rs938744401 873 dbSNP
rs189094669 875 dbSNP
rs780183041 880 dbSNP
rs1167293264 885 dbSNP
rs1051502621 886 dbSNP
rs1394186143 888 dbSNP
rs1316264346 890 dbSNP
rs1304695554 906 dbSNP
rs891782662 911 dbSNP
rs573859213 912 dbSNP
rs1015691256 917 dbSNP
rs748752025 917 dbSNP
rs1438237663 918 dbSNP
rs542873341 929 dbSNP
rs1290997846 930 dbSNP
rs1454573286 934 dbSNP
rs946076757 942 dbSNP
rs961609067 951 dbSNP
rs953960531 960 dbSNP
rs114917423 962 dbSNP
rs985365502 967 dbSNP
rs995737610 972 dbSNP
rs1467260519 993 dbSNP
rs1332046637 994 dbSNP
rs1043291442 1012 dbSNP
rs1431642193 1018 dbSNP
rs1439046259 1028 dbSNP
rs753859353 1029 dbSNP
rs548290771 1030 dbSNP
rs1485386849 1031 dbSNP
rs1258759730 1039 dbSNP
rs996317451 1043 dbSNP
rs567593388 1044 dbSNP
rs991341794 1048 dbSNP
rs1199821944 1056 dbSNP
rs1258204433 1057 dbSNP
rs1467618413 1073 dbSNP
rs1327688876 1082 dbSNP
rs1295778441 1093 dbSNP
rs912548047 1115 dbSNP
rs1381324456 1116 dbSNP
rs552724267 1130 dbSNP
rs970778786 1132 dbSNP
rs1437100637 1135 dbSNP
rs1376655518 1138 dbSNP
rs1008392737 1140 dbSNP
rs1374874135 1143 dbSNP
rs1171335609 1148 dbSNP
rs1428170135 1149 dbSNP
rs1260722590 1158 dbSNP
rs531520089 1158 dbSNP
rs778864711 1164 dbSNP
rs1433578678 1167 dbSNP
rs1256639270 1172 dbSNP
rs747952626 1176 dbSNP
rs1198678059 1177 dbSNP
rs961301578 1178 dbSNP
rs1192129042 1180 dbSNP
rs977924061 1181 dbSNP
rs1226202160 1184 dbSNP
rs923738076 1186 dbSNP
rs972430438 1187 dbSNP
rs1026827863 1188 dbSNP
rs35702101 1189 dbSNP
rs952615358 1198 dbSNP
rs936620343 1200 dbSNP
rs771116203 1201 dbSNP
rs1356508524 1203 dbSNP
rs1312742909 1208 dbSNP
rs1394822311 1209 dbSNP
rs1053705069 1214 dbSNP
rs1168604588 1219 dbSNP
rs980010940 1224 dbSNP
rs781452822 1227 dbSNP
rs576652049 1228 dbSNP
rs1454006464 1235 dbSNP
rs1336592473 1243 dbSNP
rs927125957 1247 dbSNP
rs938561153 1248 dbSNP
rs1171273703 1250 dbSNP
rs931650960 1261 dbSNP
rs546079385 1277 dbSNP
rs1459906046 1279 dbSNP
rs1295529522 1292 dbSNP
rs1196788827 1294 dbSNP
rs890221891 1299 dbSNP
rs1456168932 1300 dbSNP
rs180977336 1304 dbSNP
rs1382018657 1305 dbSNP
rs1233538429 1306 dbSNP
rs913318386 1329 dbSNP
rs1293969025 1338 dbSNP
rs1342753412 1340 dbSNP
rs946014258 1341 dbSNP
rs1293177604 1343 dbSNP
rs1338095539 1360 dbSNP
rs1043093515 1361 dbSNP
rs1218678362 1362 dbSNP
rs1266856038 1365 dbSNP
rs1488564622 1367 dbSNP
rs745972984 1369 dbSNP
rs932204994 1371 dbSNP
rs897321077 1373 dbSNP
rs564070569 1376 dbSNP
rs1489130356 1377 dbSNP
rs1194339739 1379 dbSNP
rs1417012652 1384 dbSNP
rs996184981 1394 dbSNP
rs185149721 1399 dbSNP
rs1369119803 1404 dbSNP
rs1437213752 1407 dbSNP
rs890612824 1411 dbSNP
rs1453385359 1412 dbSNP
rs959861385 1413 dbSNP
rs1287315239 1417 dbSNP
rs748063 1422 dbSNP
rs1208485954 1443 dbSNP
rs1353298405 1447 dbSNP
rs1024942696 1454 dbSNP
rs1400953900 1459 dbSNP
rs74728839 1470 dbSNP
rs1354052272 1481 dbSNP
rs1394097653 1485 dbSNP
rs571130921 1491 dbSNP
rs1402160678 1503 dbSNP
rs978164564 1505 dbSNP
rs529057863 1506 dbSNP
rs1030880492 1507 dbSNP
rs957876089 1514 dbSNP
rs989830545 1521 dbSNP
rs993905453 1531 dbSNP
rs1237927167 1534 dbSNP
rs1244557421 1538 dbSNP
rs1283388932 1545 dbSNP
rs1194900129 1549 dbSNP
rs921882473 1551 dbSNP
rs763460571 1558 dbSNP
rs1355611933 1559 dbSNP
rs1216485557 1563 dbSNP
rs1352215585 1580 dbSNP
rs769079752 1582 dbSNP
rs931865694 1589 dbSNP
rs1367000549 1593 dbSNP
rs189133272 1595 dbSNP
rs569072784 1596 dbSNP
rs181897389 1597 dbSNP
rs551264869 1599 dbSNP
rs1297394699 1605 dbSNP
rs538412619 1609 dbSNP
rs992693329 1610 dbSNP
rs1377261060 1616 dbSNP
rs568425461 1624 dbSNP
rs913278697 1627 dbSNP
rs967475924 1628 dbSNP
rs779115041 1629 dbSNP
rs1193470383 1630 dbSNP
rs564269445 1630 dbSNP
rs571263313 1639 dbSNP
rs533945699 1641 dbSNP
rs762227761 1658 dbSNP
rs767127964 1661 dbSNP
rs912151624 1662 dbSNP
rs1276627458 1664 dbSNP
rs1216514188 1672 dbSNP
rs796440925 1673 dbSNP
rs1277315653 1676 dbSNP
rs1397982465 1680 dbSNP
rs1303904794 1690 dbSNP
rs906532855 1700 dbSNP
rs781310217 1715 dbSNP
rs1390262137 1736 dbSNP
rs1306643278 1742 dbSNP
rs999632487 1749 dbSNP
rs116314179 1753 dbSNP
rs989345370 1754 dbSNP
rs1168102409 1755 dbSNP
rs1240413870 1757 dbSNP
rs1420499211 1766 dbSNP
rs1189219591 1767 dbSNP
rs1483231527 1768 dbSNP
rs1279408116 1771 dbSNP
rs1310190817 1774 dbSNP
rs1206781285 1776 dbSNP
rs1212207012 1776 dbSNP
rs1029202909 1777 dbSNP
rs898009433 1783 dbSNP
rs565415975 1795 dbSNP
rs1336630168 1797 dbSNP
rs987341539 1798 dbSNP
rs1376961081 1799 dbSNP
rs186700345 1801 dbSNP
rs192066312 1802 dbSNP
rs536789447 1804 dbSNP
rs1440622600 1807 dbSNP
rs117916485 1810 dbSNP
rs1397102544 1815 dbSNP
rs920376596 1816 dbSNP
rs754971309 1819 dbSNP
rs1412346883 1820 dbSNP
rs1423569526 1822 dbSNP
rs959996955 1828 dbSNP
rs1177453017 1833 dbSNP
rs1048565666 1842 dbSNP
rs778981155 1848 dbSNP
rs1273568468 1854 dbSNP
rs1220642840 1855 dbSNP
rs1020098072 1875 dbSNP
rs1464650893 1878 dbSNP
rs1286191712 1882 dbSNP
rs948326038 1889 dbSNP
rs967656596 1891 dbSNP
rs1375463634 1894 dbSNP
rs978833726 1897 dbSNP
rs1306504733 1905 dbSNP
rs1442618611 1915 dbSNP
rs576625369 1918 dbSNP
rs1328767251 1919 dbSNP
rs1294480419 1924 dbSNP
rs1378451909 1942 dbSNP
rs1457659420 1946 dbSNP
rs373881182 1952 dbSNP
rs182880596 1966 dbSNP
rs1420880597 1967 dbSNP
rs953322021 1968 dbSNP
rs1379747840 1975 dbSNP
rs1176918315 1977 dbSNP
rs986151403 1982 dbSNP
rs758180369 1997 dbSNP
rs4810245 2001 dbSNP
rs866019572 2004 dbSNP
rs577678716 2005 dbSNP
rs1487355670 2009 dbSNP
rs1306783190 2011 dbSNP
rs1196672001 2012 dbSNP
rs919424490 2015 dbSNP
rs1216368896 2018 dbSNP
rs930819871 2031 dbSNP
rs34597314 2036 dbSNP
rs1011373596 2037 dbSNP
rs1048093152 2041 dbSNP
rs186704427 2047 dbSNP
rs1001127794 2051 dbSNP
rs560220061 2074 dbSNP
rs1055451940 2075 dbSNP
rs1192069607 2076 dbSNP
rs1401133260 2083 dbSNP
rs1360521244 2084 dbSNP
rs895495754 2101 dbSNP
rs1436599060 2102 dbSNP
rs1008792112 2111 dbSNP
rs1014170130 2115 dbSNP
rs62201391 2116 dbSNP
rs1263557500 2125 dbSNP
rs1194190534 2130 dbSNP
rs961912769 2131 dbSNP
rs746121893 2132 dbSNP
rs971709027 2138 dbSNP
rs542752703 2150 dbSNP
rs1485683288 2151 dbSNP
rs1254946946 2153 dbSNP
rs1000035199 2156 dbSNP
rs562496476 2157 dbSNP
rs1308954199 2163 dbSNP
rs991646536 2179 dbSNP
rs1219557885 2180 dbSNP
rs953457685 2188 dbSNP
rs369074568 2190 dbSNP
rs146744489 2191 dbSNP
rs571228284 2203 dbSNP
rs1018941775 2210 dbSNP
rs1464720549 2213 dbSNP
rs928218296 2217 dbSNP
rs1171651634 2219 dbSNP
rs527607056 2220 dbSNP
rs1052453211 2224 dbSNP
rs972306646 2228 dbSNP
rs919503749 2229 dbSNP
rs1254858061 2239 dbSNP
rs1198302610 2242 dbSNP
rs1297329720 2243 dbSNP
rs1318722142 2244 dbSNP
rs930788679 2245 dbSNP
rs1481331379 2270 dbSNP
rs1258240788 2273 dbSNP
rs1232688441 2278 dbSNP
rs575946283 2285 dbSNP
rs926822266 2286 dbSNP
rs117595428 2287 dbSNP
rs567522904 2288 dbSNP
rs1394292961 2293 dbSNP
rs778672468 2314 dbSNP
rs893789881 2320 dbSNP
rs1397826328 2321 dbSNP
rs139428601 2325 dbSNP
rs372921141 2329 dbSNP
rs1473085387 2331 dbSNP
rs1487492412 2339 dbSNP
rs1367759075 2344 dbSNP
rs780108211 2347 dbSNP
rs949761105 2351 dbSNP
rs536347144 2352 dbSNP
rs556625398 2354 dbSNP
rs61390556 2355 dbSNP
rs1456206321 2356 dbSNP
rs543780339 2357 dbSNP
rs1000002781 2359 dbSNP
rs1477871644 2362 dbSNP
rs1008703665 2368 dbSNP
rs1018695301 2372 dbSNP
rs1357501637 2373 dbSNP
rs1410992249 2376 dbSNP
rs539252002 2378 dbSNP
rs6124098 2379 dbSNP
rs1406795853 2393 dbSNP
rs961945350 2400 dbSNP
rs1032835373 2401 dbSNP
rs888988616 2402 dbSNP
rs991285177 2404 dbSNP
rs7266267 2407 dbSNP
rs1389776553 2414 dbSNP
rs1161352568 2415 dbSNP
rs6124099 2418 dbSNP
rs1340976525 2424 dbSNP
rs1380350903 2425 dbSNP
rs1019452345 2428 dbSNP
rs572756346 2431 dbSNP
rs144083723 2433 dbSNP
rs1254418022 2437 dbSNP
rs1199141653 2448 dbSNP
rs1358531171 2449 dbSNP
rs553799171 2455 dbSNP
rs1267140441 2460 dbSNP
rs1285524989 2470 dbSNP
rs982277825 2471 dbSNP
rs972491327 2473 dbSNP
rs1356542175 2474 dbSNP
rs1026495166 2477 dbSNP
rs952284672 2478 dbSNP
rs577544979 2479 dbSNP
rs926791215 2480 dbSNP
rs150978850 2484 dbSNP
rs562616372 2485 dbSNP
rs1330268021 2489 dbSNP
rs1186033029 2490 dbSNP
rs1321400075 2495 dbSNP
rs774820982 2501 dbSNP
rs1383837277 2511 dbSNP
rs531375015 2524 dbSNP
rs762126613 2528 dbSNP
rs946694398 2530 dbSNP
rs1172760337 2532 dbSNP
rs1473475821 2536 dbSNP
rs1163514934 2538 dbSNP
rs1379243144 2541 dbSNP
rs34143497 2550 dbSNP
rs1417636936 2555 dbSNP
rs1160305994 2557 dbSNP
rs745542021 2561 dbSNP
rs544781155 2563 dbSNP
rs1360910127 2572 dbSNP
rs1216553810 2576 dbSNP
rs1413884741 2578 dbSNP
rs1280880345 2583 dbSNP
rs140846616 2584 dbSNP
rs527574063 2585 dbSNP
rs1448793582 2589 dbSNP
rs1040219806 2606 dbSNP
rs897662247 2612 dbSNP
rs547336281 2613 dbSNP
rs768902816 2615 dbSNP
rs545716993 2617 dbSNP
rs1360357143 2619 dbSNP
rs1316600614 2627 dbSNP
rs1344729111 2631 dbSNP
rs1027974211 2632 dbSNP
rs567505622 2633 dbSNP
rs190304663 2634 dbSNP
rs549972930 2651 dbSNP
rs1478979324 2654 dbSNP
rs1215883304 2655 dbSNP
rs1187556007 2656 dbSNP
rs1193541489 2680 dbSNP
rs1477157925 2683 dbSNP
rs1239274885 2687 dbSNP
rs1237026871 2690 dbSNP
rs1007805946 2692 dbSNP
rs1180095831 2693 dbSNP
rs1040434815 2699 dbSNP
rs369555070 2704 dbSNP
rs901937706 2705 dbSNP
rs1318284862 2708 dbSNP
rs1277371858 2712 dbSNP
rs372987729 2713 dbSNP
rs539164361 2715 dbSNP
rs1284716670 2724 dbSNP
rs1381320656 2724 dbSNP
rs1446575596 2727 dbSNP
rs1380722517 2737 dbSNP
rs993625116 2740 dbSNP
rs1356953870 2750 dbSNP
rs552790825 2755 dbSNP
rs566321993 2756 dbSNP
rs1401458768 2761 dbSNP
rs535288207 2770 dbSNP
rs971142350 2782 dbSNP
rs1404195877 2784 dbSNP
rs952086239 2787 dbSNP
rs1464513866 2788 dbSNP
rs1416501101 2795 dbSNP
rs1182960567 2797 dbSNP
rs981179370 2809 dbSNP
rs1006421715 2822 dbSNP
rs956840497 2823 dbSNP
rs555252573 2829 dbSNP
rs1033902167 2830 dbSNP
rs959530272 2831 dbSNP
rs988438700 2832 dbSNP
rs776338384 2833 dbSNP
rs992756366 2834 dbSNP
rs1398190496 2837 dbSNP
rs916979532 2839 dbSNP
rs145536224 2844 dbSNP
rs78887133 2845 dbSNP
rs977195103 2847 dbSNP
rs759093709 2852 dbSNP
rs946950382 2858 dbSNP
rs555912575 2863 dbSNP
rs1330920114 2873 dbSNP
rs1231463989 2876 dbSNP
rs765304688 2880 dbSNP
rs1328875916 2887 dbSNP
rs1460731829 2893 dbSNP
rs576070201 2894 dbSNP
rs182164171 2902 dbSNP
rs944834053 2907 dbSNP
rs1256921097 2924 dbSNP
rs1383436107 2925 dbSNP
rs564737046 2934 dbSNP
rs1456044171 2941 dbSNP
rs1440546001 2943 dbSNP
rs897694796 2954 dbSNP
rs557523131 2959 dbSNP
rs929145996 2974 dbSNP
rs1054332639 2979 dbSNP
rs571914879 2980 dbSNP
rs540889375 2983 dbSNP
rs758216922 2986 dbSNP
rs1250727610 3006 dbSNP
rs186805835 3009 dbSNP
rs1022670430 3012 dbSNP
rs73908207 3017 dbSNP
rs1002646412 3018 dbSNP
rs756390897 3028 dbSNP
rs1379153013 3034 dbSNP
rs1388179087 3040 dbSNP
rs993986900 3042 dbSNP
rs1478350197 3046 dbSNP
rs1294535882 3052 dbSNP
rs1047836148 3058 dbSNP
rs1364322630 3061 dbSNP
rs1300605113 3062 dbSNP
rs1208255343 3067 dbSNP
rs550127785 3079 dbSNP
rs563568131 3080 dbSNP
rs1379798116 3081 dbSNP
rs1006181431 3087 dbSNP
rs1421630060 3092 dbSNP
rs1033871028 3097 dbSNP
rs1467213484 3104 dbSNP
rs1425596741 3111 dbSNP
rs954935 3119 dbSNP
rs780245931 3124 dbSNP
rs1332325994 3130 dbSNP
rs988718339 3134 dbSNP
rs867307133 3138 dbSNP
rs959905706 3141 dbSNP
rs1283304873 3142 dbSNP
rs1385303704 3146 dbSNP
rs749422095 3147 dbSNP
rs755023324 3148 dbSNP
rs532647071 3150 dbSNP
rs977133082 3155 dbSNP
rs1315551873 3158 dbSNP
rs1219869700 3168 dbSNP
rs1401188550 3172 dbSNP
rs1251538036 3173 dbSNP
rs192387444 3177 dbSNP
rs1264184248 3179 dbSNP
rs1287252569 3191 dbSNP
rs1207688498 3199 dbSNP
rs957001894 3205 dbSNP
rs1269265354 3222 dbSNP
rs1175639090 3226 dbSNP
rs1479304537 3227 dbSNP
rs1194253529 3228 dbSNP
rs1477482697 3230 dbSNP
rs1490443994 3232 dbSNP
rs1192897208 3237 dbSNP
rs1421333174 3239 dbSNP
rs1201741327 3241 dbSNP
rs989826714 3242 dbSNP
rs1483293006 3247 dbSNP
rs976027961 3252 dbSNP
rs1478852130 3255 dbSNP
rs1280545770 3257 dbSNP
rs1321818196 3257 dbSNP
rs910246109 3263 dbSNP
rs943262085 3283 dbSNP
rs1219772840 3296 dbSNP
rs1171305688 3308 dbSNP
rs1340522095 3311 dbSNP
rs919363360 3312 dbSNP
rs1397802529 3324 dbSNP
rs1380007442 3340 dbSNP
rs1302439839 3346 dbSNP
rs1468467762 3349 dbSNP
rs1402166535 3353 dbSNP
rs1367953422 3357 dbSNP
rs1171197780 3360 dbSNP
rs1465035500 3364 dbSNP
rs929365660 3391 dbSNP
rs1189549142 3393 dbSNP
rs1165188166 3395 dbSNP
rs1040331116 3396 dbSNP
rs1049373516 3397 dbSNP
rs1339158208 3400 dbSNP
rs923089829 3409 dbSNP
rs929149644 3412 dbSNP
rs1047765638 3413 dbSNP
rs1450705747 3420 dbSNP
rs1379479430 3431 dbSNP
rs1445690719 3435 dbSNP
rs1342863609 3445 dbSNP
rs1394108669 3449 dbSNP
rs887881887 3455 dbSNP
rs1367366286 3460 dbSNP
rs566235997 3463 dbSNP
rs535246972 3470 dbSNP
rs1002553017 3477 dbSNP
rs559932131 3500 dbSNP
rs1055038327 3506 dbSNP
rs1320572130 3510 dbSNP
rs778820876 3515 dbSNP
rs1266804931 3517 dbSNP
rs891547631 3522 dbSNP
rs1215552505 3526 dbSNP
rs1011319011 3543 dbSNP
rs1489262740 3544 dbSNP
rs34381606 3549 dbSNP
rs371203534 3553 dbSNP
rs1355960563 3565 dbSNP
rs1310197446 3566 dbSNP
rs548569267 3568 dbSNP
rs1239748893 3575 dbSNP
rs1333747601 3583 dbSNP
rs1447642039 3584 dbSNP
rs1387275405 3589 dbSNP
rs41276980 3592 dbSNP
rs1025229845 3593 dbSNP
rs1255604696 3600 dbSNP
rs968227811 3603 dbSNP
rs902648353 3609 dbSNP
rs1468320810 3613 dbSNP
rs1422087613 3614 dbSNP
rs146933139 3621 dbSNP
rs1031402901 3623 dbSNP
rs1386027783 3625 dbSNP
rs10392 3627 dbSNP
rs772683404 3635 dbSNP
rs747331020 3637 dbSNP
rs1017680451 3672 dbSNP
rs964447922 3674 dbSNP
rs976055557 3678 dbSNP
rs919228481 3682 dbSNP
rs1286896352 3699 dbSNP
rs1362835279 3702 dbSNP
rs575681218 3706 dbSNP
rs1348892905 3707 dbSNP
rs976365180 3711 dbSNP
rs867930225 3717 dbSNP
rs868492127 3718 dbSNP
rs1276838096 3721 dbSNP
rs1233634130 3723 dbSNP
rs116621334 3731 dbSNP
rs1281261144 3735 dbSNP
rs1401808427 3736 dbSNP
rs929111946 3746 dbSNP
rs983264787 3751 dbSNP
rs984888562 3770 dbSNP
rs1297103697 3773 dbSNP
rs41276982 3786 dbSNP
rs948566526 3796 dbSNP
rs1393742049 3798 dbSNP
rs1044222075 3801 dbSNP
rs1478532715 3804 dbSNP
rs1429062393 3812 dbSNP
rs942104543 3814 dbSNP
rs1197867877 3831 dbSNP
rs1479121733 3834 dbSNP
rs1055247798 3841 dbSNP
rs1263996606 3845 dbSNP
rs1215077382 3848 dbSNP
rs1445368189 3850 dbSNP
rs571877559 3851 dbSNP
rs1201280775 3853 dbSNP
rs1314450751 3857 dbSNP
rs1261071803 3858 dbSNP
rs1220374387 3859 dbSNP
rs561363822 3875 dbSNP
rs117511255 3877 dbSNP
rs949423907 3882 dbSNP
rs1047059305 3885 dbSNP
rs1052804616 3895 dbSNP
rs902784254 3899 dbSNP
rs891458855 3901 dbSNP
rs1405792946 3907 dbSNP
rs999803588 3919 dbSNP
rs560956289 3931 dbSNP
rs1467516635 3934 dbSNP
rs574662028 3936 dbSNP
rs1042800485 3938 dbSNP
rs543394781 3939 dbSNP
rs894013773 3942 dbSNP
rs1011328249 3943 dbSNP
rs563651405 3951 dbSNP
rs370295097 3953 dbSNP
rs964697108 3957 dbSNP
rs1183603094 3970 dbSNP
rs764861107 3980 dbSNP
rs975785737 3982 dbSNP
rs1200220239 3983 dbSNP
rs1030639029 3992 dbSNP
rs138518848 3993 dbSNP
rs866164759 4002 dbSNP
rs1212766376 4004 dbSNP
rs1357812655 4016 dbSNP
rs774801806 4019 dbSNP
rs1451458357 4021 dbSNP
rs1176982942 4022 dbSNP
rs909040801 4024 dbSNP
rs941905078 4030 dbSNP
rs950728205 4031 dbSNP
rs991280940 4039 dbSNP
rs1332967711 4057 dbSNP
rs1464110109 4058 dbSNP
rs1355514766 4072 dbSNP
rs144118899 4075 dbSNP
rs1338198106 4079 dbSNP
rs916685232 4080 dbSNP
rs985309264 4084 dbSNP
rs949391895 4106 dbSNP
rs909312109 4107 dbSNP
rs1046376532 4109 dbSNP
rs970106502 4118 dbSNP
rs979939984 4126 dbSNP
rs762949701 4127 dbSNP
rs938621001 4134 dbSNP
rs1202340979 4138 dbSNP
rs935561962 4139 dbSNP
rs1244529007 4144 dbSNP
rs1290515518 4144 dbSNP
rs559905553 4144 dbSNP
rs188370188 4145 dbSNP
rs1007066413 4152 dbSNP
rs763929637 4154 dbSNP
rs548747787 4157 dbSNP
rs1298020554 4158 dbSNP
rs1440638113 4159 dbSNP
rs10477 4160 dbSNP
rs1304292922 4165 dbSNP
rs1263889059 4167 dbSNP
rs1383494080 4168 dbSNP
rs1160649805 4171 dbSNP
rs997696337 4173 dbSNP
rs1406974729 4174 dbSNP
rs889548464 4177 dbSNP
rs942416998 4178 dbSNP
rs531234178 4180 dbSNP
rs550995883 4187 dbSNP
rs950418771 4192 dbSNP
rs1240207916 4193 dbSNP
rs1287607848 4201 dbSNP
rs1216864738 4202 dbSNP
rs1004751283 4207 dbSNP
rs1016145159 4208 dbSNP
rs193184374 4209 dbSNP
rs754093917 4210 dbSNP
rs569270221 4214 dbSNP
rs1177742519 4215 dbSNP
rs916424450 4216 dbSNP
rs1300191875 4225 dbSNP
rs1429417431 4226 dbSNP
rs1464604602 4233 dbSNP
rs1328885071 4235 dbSNP
rs1344773553 4244 dbSNP
rs970825278 4246 dbSNP
rs1429791049 4251 dbSNP
rs1355848999 4258 dbSNP
rs1442472848 4260 dbSNP
rs982639965 4266 dbSNP
rs923935890 4293 dbSNP
rs886660919 4301 dbSNP
rs184694206 4309 dbSNP
rs1225322557 4312 dbSNP
rs1258529976 4318 dbSNP
rs1283809481 4344 dbSNP
rs1314275766 4346 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gauucugguucggaGGAAGGGa 5'
                        ||||||| 
Target 5' -----------auaCCUUCCCa 3'
1 - 11
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000299824.1 | 3UTR | AUACCUUCCCAUCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
215 hsa-miR-4747-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT061689 BTG2 BTG anti-proliferation factor 2 2 2
MIRT062834 BCL7A BCL tumor suppressor 7A 2 2
MIRT079371 CCDC137 coiled-coil domain containing 137 2 2
MIRT081190 MIDN midnolin 2 4
MIRT081724 ZNF507 zinc finger protein 507 2 2
MIRT110565 ZMYND11 zinc finger MYND-type containing 11 2 2
MIRT133724 SKI SKI proto-oncogene 2 4
MIRT146689 MINK1 misshapen like kinase 1 2 2
MIRT150676 SLC27A1 solute carrier family 27 member 1 2 2
MIRT159196 NRBP1 nuclear receptor binding protein 1 2 2
MIRT180865 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 2
MIRT190659 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT196111 MPRIP myosin phosphatase Rho interacting protein 2 2
MIRT232390 SP1 Sp1 transcription factor 2 2
MIRT331070 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 4
MIRT338632 SHMT2 serine hydroxymethyltransferase 2 2 2
MIRT407441 CTDSP1 CTD small phosphatase 1 2 2
MIRT444276 NKX6-1 NK6 homeobox 1 2 2
MIRT444834 PDE6D phosphodiesterase 6D 2 2
MIRT445452 EXT1 exostosin glycosyltransferase 1 2 2
MIRT445644 NPY4R neuropeptide Y receptor Y4 2 2
MIRT446157 RPL12 ribosomal protein L12 2 2
MIRT446608 HIP1 huntingtin interacting protein 1 2 2
MIRT447108 CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2 2
MIRT449314 MRO maestro 2 2
MIRT450305 DRAXIN dorsal inhibitory axon guidance protein 2 2
MIRT451245 ZNF444 zinc finger protein 444 2 2
MIRT451714 OLR1 oxidized low density lipoprotein receptor 1 2 2
MIRT451908 ILK integrin linked kinase 2 2
MIRT452183 KIAA1456 KIAA1456 2 2
MIRT452610 REPIN1 replication initiator 1 2 2
MIRT453422 GLG1 golgi glycoprotein 1 2 2
MIRT454006 ALKBH5 alkB homolog 5, RNA demethylase 2 2
MIRT455072 ARHGAP39 Rho GTPase activating protein 39 2 2
MIRT455319 TTLL9 tubulin tyrosine ligase like 9 2 2
MIRT455357 KDM5C lysine demethylase 5C 2 2
MIRT455589 TAF12 TATA-box binding protein associated factor 12 2 2
MIRT455711 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2 2
MIRT455860 TMEM254 transmembrane protein 254 2 2
MIRT455919 RAPGEF1 Rap guanine nucleotide exchange factor 1 2 2
MIRT455946 CYP4A22 cytochrome P450 family 4 subfamily A member 22 2 2
MIRT456935 LRP10 LDL receptor related protein 10 2 2
MIRT457223 AP3D1 adaptor related protein complex 3 delta 1 subunit 2 2
MIRT457431 NOL10 nucleolar protein 10 2 2
MIRT457470 SLC35F6 solute carrier family 35 member F6 2 2
MIRT457907 ZNF212 zinc finger protein 212 2 2
MIRT458046 TSEN54 tRNA splicing endonuclease subunit 54 2 2
MIRT458073 RNLS renalase, FAD dependent amine oxidase 2 2
MIRT458234 NXPH3 neurexophilin 3 2 2
MIRT458307 TNFAIP8L3 TNF alpha induced protein 8 like 3 2 2
MIRT458378 ITM2C integral membrane protein 2C 2 2
MIRT458967 ZNF436 zinc finger protein 436 2 2
MIRT459099 CYP4A11 cytochrome P450 family 4 subfamily A member 11 2 2
MIRT459446 TMEM37 transmembrane protein 37 2 2
MIRT459671 VPS37C VPS37C, ESCRT-I subunit 2 2
MIRT460727 ASXL3 additional sex combs like 3, transcriptional regulator 2 2
MIRT460744 SRP14 signal recognition particle 14 2 2
MIRT461531 C14orf1 ergosterol biosynthesis 28 homolog 2 2
MIRT461752 DDX11 DEAD/H-box helicase 11 2 2
MIRT461837 F2RL3 F2R like thrombin or trypsin receptor 3 2 2
MIRT462019 RIF1 replication timing regulatory factor 1 2 2
MIRT462631 PHF5A PHD finger protein 5A 2 2
MIRT462772 ZNF8 zinc finger protein 8 2 2
MIRT463032 ZNF689 zinc finger protein 689 2 2
MIRT463886 WNT7B Wnt family member 7B 2 2
MIRT463995 WDTC1 WD and tetratricopeptide repeats 1 2 2
MIRT464371 URM1 ubiquitin related modifier 1 2 2
MIRT465342 TPM3 tropomyosin 3 2 4
MIRT465515 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT465602 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT465697 TNPO2 transportin 2 2 10
MIRT466988 SSRP1 structure specific recognition protein 1 2 4
MIRT467630 SLC7A5 solute carrier family 7 member 5 2 2
MIRT468132 SH3PXD2A SH3 and PX domains 2A 2 2
MIRT468322 SF3B3 splicing factor 3b subunit 3 2 2
MIRT468502 SESN2 sestrin 2 2 2
MIRT468881 RREB1 ras responsive element binding protein 1 2 2
MIRT469322 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT469562 RARA retinoic acid receptor alpha 2 2
MIRT469898 PTRF caveolae associated protein 1 2 2
MIRT470045 PTGFRN prostaglandin F2 receptor inhibitor 2 2
MIRT470068 PTGES2 prostaglandin E synthase 2 2 2
MIRT470238 PRRC2A proline rich coiled-coil 2A 2 2
MIRT470390 PPP1R16B protein phosphatase 1 regulatory subunit 16B 2 2
MIRT470500 PPP1R11 protein phosphatase 1 regulatory inhibitor subunit 11 2 2
MIRT470689 POLR2D RNA polymerase II subunit D 2 2
MIRT470704 POGK pogo transposable element derived with KRAB domain 2 2
MIRT471083 PIK3C2B phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta 2 2
MIRT472482 NACC2 NACC family member 2 2 2
MIRT473583 MAT2A methionine adenosyltransferase 2A 2 2
MIRT474554 KLHDC3 kelch domain containing 3 2 2
MIRT474651 KLF13 Kruppel like factor 13 2 2
MIRT474843 KHSRP KH-type splicing regulatory protein 2 2
MIRT474934 KCTD15 potassium channel tetramerization domain containing 15 2 2
MIRT475573 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2 2
MIRT476045 GRSF1 G-rich RNA sequence binding factor 1 2 2
MIRT476080 GRB2 growth factor receptor bound protein 2 2 2
MIRT476440 GBA2 glucosylceramidase beta 2 2 2
MIRT476764 FOSL2 FOS like 2, AP-1 transcription factor subunit 2 2
MIRT478785 CRTC2 CREB regulated transcription coactivator 2 2 2
MIRT479287 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT479505 CDH6 cadherin 6 2 2
MIRT479732 CCND1 cyclin D1 2 6
MIRT480352 C5orf24 chromosome 5 open reading frame 24 2 2
MIRT480407 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT480859 BHLHB9 basic helix-loop-helix family member b9 2 2
MIRT481445 ARRB2 arrestin beta 2 2 2
MIRT481732 APH1A aph-1 homolog A, gamma-secretase subunit 2 2
MIRT481824 AP2M1 adaptor related protein complex 2 mu 1 subunit 2 2
MIRT482566 ABHD2 abhydrolase domain containing 2 2 2
MIRT482607 ABHD14B abhydrolase domain containing 14B 2 2
MIRT483144 SYCE1L synaptonemal complex central element protein 1 like 2 2
MIRT483214 APOA1 apolipoprotein A1 2 6
MIRT483878 TGIF1 TGFB induced factor homeobox 1 2 2
MIRT483917 SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 2 2
MIRT483939 LENG8 leukocyte receptor cluster member 8 2 4
MIRT484420 SNX19 sorting nexin 19 2 2
MIRT484489 SLC9A1 solute carrier family 9 member A1 2 2
MIRT484612 SIX3 SIX homeobox 3 2 6
MIRT484705 RNF11 ring finger protein 11 2 2
MIRT485107 SHISA6 shisa family member 6 2 2
MIRT485354 MYO1C myosin IC 2 4
MIRT485609 FOSL1 FOS like 1, AP-1 transcription factor subunit 2 4
MIRT487311 GLTSCR1 BRD4 interacting chromatin remodeling complex associated protein 2 2
MIRT487417 CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 2 2
MIRT487695 CDK14 cyclin dependent kinase 14 2 2
MIRT487791 GPR20 G protein-coupled receptor 20 2 4
MIRT488042 PABPC1L2B poly(A) binding protein cytoplasmic 1 like 2B 2 2
MIRT488058 PABPC1L2A poly(A) binding protein cytoplasmic 1 like 2A 2 2
MIRT488237 DNLZ DNL-type zinc finger 2 4
MIRT488764 FXYD1 FXYD domain containing ion transport regulator 1 2 2
MIRT489401 TUBB2A tubulin beta 2A class IIa 2 2
MIRT489777 GRINA glutamate ionotropic receptor NMDA type subunit associated protein 1 2 2
MIRT490099 FN3K fructosamine 3 kinase 2 2
MIRT490290 ISL2 ISL LIM homeobox 2 2 2
MIRT490378 LHFPL3 LHFPL tetraspan subfamily member 3 2 2
MIRT491329 GFER growth factor, augmenter of liver regeneration 2 2
MIRT491435 MSX2 msh homeobox 2 2 2
MIRT491769 ZNF385A zinc finger protein 385A 2 2
MIRT491922 WNK2 WNK lysine deficient protein kinase 2 2 2
MIRT491983 UNK unkempt family zinc finger 2 2
MIRT492228 SLC48A1 solute carrier family 48 member 1 2 2
MIRT492404 SDK1 sidekick cell adhesion molecule 1 2 2
MIRT492767 PDGFB platelet derived growth factor subunit B 2 2
MIRT492966 NCS1 neuronal calcium sensor 1 2 2
MIRT493295 LLGL2 LLGL2, scribble cell polarity complex component 2 2
MIRT493650 HDLBP high density lipoprotein binding protein 2 2
MIRT493913 FAM127B retrotransposon Gag like 8A 2 4
MIRT495601 NKX2-5 NK2 homeobox 5 2 2
MIRT496875 AHCYL2 adenosylhomocysteinase like 2 2 2
MIRT498514 MYH14 myosin heavy chain 14 2 2
MIRT499178 RBPJL recombination signal binding protein for immunoglobulin kappa J region like 2 2
MIRT502143 KIF5B kinesin family member 5B 2 8
MIRT502692 CSNK1G1 casein kinase 1 gamma 1 2 4
MIRT508460 HOXB6 homeobox B6 2 4
MIRT510430 ZNF207 zinc finger protein 207 2 6
MIRT511837 GPATCH8 G-patch domain containing 8 2 4
MIRT512368 CPM carboxypeptidase M 2 2
MIRT512506 BTBD19 BTB domain containing 19 2 2
MIRT513065 ANKRD45 ankyrin repeat domain 45 2 2
MIRT513267 SCUBE1 signal peptide, CUB domain and EGF like domain containing 1 2 4
MIRT513575 EVX1 even-skipped homeobox 1 2 2
MIRT515051 EBNA1BP2 EBNA1 binding protein 2 2 2
MIRT515790 COL4A3BP collagen type IV alpha 3 binding protein 2 2
MIRT521657 PRKD3 protein kinase D3 2 2
MIRT522679 LUZP1 leucine zipper protein 1 2 6
MIRT528845 RAB32 RAB32, member RAS oncogene family 2 2
MIRT533569 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT543738 DHCR7 7-dehydrocholesterol reductase 2 2
MIRT544295 TSPYL1 TSPY like 1 2 2
MIRT544857 MYH2 myosin heavy chain 2 2 4
MIRT557323 HIATL1 major facilitator superfamily domain containing 14B 2 4
MIRT560522 TMEM98 transmembrane protein 98 2 2
MIRT561565 SLC6A9 solute carrier family 6 member 9 2 2
MIRT562374 ERI2 ERI1 exoribonuclease family member 2 2 2
MIRT565780 SEMA6D semaphorin 6D 2 2
MIRT569548 UNC119B unc-119 lipid binding chaperone B 2 2
MIRT569944 PRRT2 proline rich transmembrane protein 2 2 2
MIRT570016 COL1A2 collagen type I alpha 2 chain 2 2
MIRT572163 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT572322 HSPB6 heat shock protein family B (small) member 6 2 2
MIRT573495 IQSEC3 IQ motif and Sec7 domain 3 2 2
MIRT574139 MARVELD1 MARVEL domain containing 1 2 2
MIRT609449 CCDC149 coiled-coil domain containing 149 2 2
MIRT610619 ARHGAP18 Rho GTPase activating protein 18 2 2
MIRT623355 LZIC leucine zipper and CTNNBIP1 domain containing 2 2
MIRT629854 ACOX1 acyl-CoA oxidase 1 2 2
MIRT630516 CDC73 cell division cycle 73 2 2
MIRT632535 PSMB2 proteasome subunit beta 2 2 2
MIRT633975 SLC35E2 solute carrier family 35 member E2 2 2
MIRT636408 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 2
MIRT641722 LTBR lymphotoxin beta receptor 2 2
MIRT642661 RGS6 regulator of G protein signaling 6 2 2
MIRT649649 MAST3 microtubule associated serine/threonine kinase 3 2 2
MIRT650367 MOCS3 molybdenum cofactor synthesis 3 2 2
MIRT651355 ZBTB40 zinc finger and BTB domain containing 40 2 2
MIRT664840 HUS1 HUS1 checkpoint clamp component 2 2
MIRT667322 MYH9 myosin heavy chain 9 2 2
MIRT670680 SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 2 2
MIRT674922 TRPM6 transient receptor potential cation channel subfamily M member 6 2 2
MIRT675919 CYP51A1 cytochrome P450 family 51 subfamily A member 1 2 2
MIRT676493 GJD3 gap junction protein delta 3 2 2
MIRT680162 ZDHHC20 zinc finger DHHC-type containing 20 2 2
MIRT688008 GSN gelsolin 2 2
MIRT688997 ATP6AP1 ATPase H+ transporting accessory protein 1 2 2
MIRT700337 RAB4A RAB4A, member RAS oncogene family 2 2
MIRT701344 NR4A3 nuclear receptor subfamily 4 group A member 3 2 2
MIRT703519 FKBP15 FK506 binding protein 15 2 2
MIRT703901 EPT1 selenoprotein I 2 2
MIRT705565 ARHGEF18 Rho/Rac guanine nucleotide exchange factor 18 2 2
MIRT709709 DNAJC11 DnaJ heat shock protein family (Hsp40) member C11 2 2
MIRT713108 TMBIM4 transmembrane BAX inhibitor motif containing 4 2 2
MIRT718426 ZNF85 zinc finger protein 85 2 2
MIRT719236 CYSLTR2 cysteinyl leukotriene receptor 2 2 2
MIRT719326 STAC SH3 and cysteine rich domain 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4747 Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4747-5p Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-4747-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4747-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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