miRTarBase - #MIRT470843


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pre-miRNA Information
pre-miRNA hsa-mir-378g   
Genomic Coordinates chr1: 94745860 - 94745900
Description Homo sapiens miR-378g stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-378g
Sequence 2| ACUGGGCUUGGAGUCAGAAG |21
Evidence Experimental
Experiments Illumina
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PLXND1   
Synonyms PLEXD1
Description plexin D1
Transcript NM_015103   
Expression
Putative miRNA Targets on PLXND1
3'UTR of PLXND1
(miRNA target sites are highlighted)		 
>PLXND1|NM_015103|3'UTR
   1 GACACATGGAGAGTTGGTCAGGCTGCTGCTGGGAGAAATGGACGCCCACTGGGCCTCAACTTGATCTTCTACCCCGTGCC
  81 TGTGACTCAGACTGGGAAATACTGAGCAGAGACGGCTGGGGCGGGGGCAGGAGGAGGGGCTGCTCTCTGAGACAGGGGCG
 161 CCCCCGCCTTGACCCCTGGGCACCTCCATCCCCTCCCACCTGTCCCCAGATCAGTCTCTGGGATGGAGGCCAGAGAGCTG
 241 GTCAGGCTCCCCCATCTGCCCAGCACGGCCTGCACTGTGCCCACCCACTTGCTCCACAACGTCCAGTTGGTCCTGCTGCC
 321 AAGAGCCCCGTGCATCCAGGCGGCCAAGCACAAACTGGGGGAGAGGAGGCCGCCAGCCCGGAGGCTGCAGCCCAGAAACT
 401 CTACCTCATCCACACTGGTGCAGGGAGCCCTCCTTGAACTGACCTTTGATTGGTTTCTGCTTCAACTACCAAAATGTTAT
 481 CTCCACTTCCCCCTCACCCGTAGAGGATCCTGGCCACAGACAGTTTCAAGTAGTGTCAGATTTTTGTTGCTTGGGCGGCT
 561 GTTGGTAGAGTGGGCAGTGCCCGCGCCATGGGGTGCTCTGTGGGCTTCTCCAGGAGCAGGGAGGGTGGAGGGGAGGGATG
 641 GGGGGCACAGGAGCTGGGAGCCCCGTCTCCAGGAAAAGGAGAGGGGTTAAGATGCACCGAGGCTGTAGCTGGGCTACTTG
 721 ATCTTGCTGAAAGTGTTTCTAAAGATAGCACCACTTTTTTTTTTAAAGCTTTTATATATTAAAAAACGTATCATGCACCA
 801 ACTGTGAATAGCTGCCGCTTGCGCAGAGGACCCGGGGAGGGGTCCCGAGAGGCTCCCCATGCAACACTGGAAATGACTGT
 881 TCCAGAGAGCGGGCAGACCTGGCAGAGCGCCCCTGGCGCCTGAGACTACCACCCACTCCGTTCCTGCCAGAAACGACCCT
 961 CTGTGGCCGATGGGCCATGCGGGCCCCTCGCAGCCAACTCAGCCAGTGTTGGGACTGGCTCAGAGCCCATGGGGGCTGGA
1041 GGGGGGCAGCTGGGACTCTGGAATCTTCTTTATAATAAAAGCCTTACGGACAAACCTAC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaagaCUGAGGUUCGGGUCa 5'
               |:|| | ||||||| 
Target 5' ccggaGGCTGC-AGCCCAGa 3'
 378 - 396 150.00 -18.00
2 
miRNA  3' gaaGACUGAGGUUCGGGUca 5'
             |||:||| :||||||  
Target 5' ggaCTGGCTCAGAGCCCAtg 3'
 1012 - 1031 149.00 -22.00
3 
miRNA  3' gaAGACUGA---GGU--UCGGGUCa 5'
            || |:||   |||   |||||| 
Target 5' ggTCAGGCTCCCCCATCTGCCCAGc 3'
 240 - 264 124.00 -17.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN20052808 11 COSMIC
COSN30492490 26 COSMIC
COSN8488210 42 COSMIC
COSN26989602 43 COSMIC
COSN30679234 65 COSMIC
COSN25433933 85 COSMIC
COSN30518407 104 COSMIC
COSN30179199 109 COSMIC
COSN30177675 113 COSMIC
COSN31612713 116 COSMIC
COSN30101987 122 COSMIC
COSN30767672 126 COSMIC
COSN30154020 155 COSMIC
COSN30499166 160 COSMIC
COSN28874374 173 COSMIC
COSN7620674 340 COSMIC
COSN24990371 347 COSMIC
COSN26634096 500 COSMIC
COSN31521333 523 COSMIC
COSN31520947 543 COSMIC
COSN31545427 585 COSMIC
COSN31530756 612 COSMIC
COSN24386090 623 COSMIC
COSN32065816 643 COSMIC
COSN20040774 665 COSMIC
COSN22863387 724 COSMIC
COSN31488218 754 COSMIC
COSN20064916 755 COSMIC
COSN20074717 764 COSMIC
COSN26634162 792 COSMIC
COSN30702712 852 COSMIC
COSN7817048 890 COSMIC
COSN22085327 918 COSMIC
COSN30174372 950 COSMIC
COSN8488209 969 COSMIC
COSN28844169 975 COSMIC
COSN28880597 994 COSMIC
COSN30542742 1032 COSMIC
COSN30177113 1065 COSMIC
COSN30543775 1065 COSMIC
COSN31519829 1068 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs372159281 1 dbSNP
rs764092034 6 dbSNP
rs369089083 8 dbSNP
rs572616073 9 dbSNP
rs1310597083 10 dbSNP
rs781377785 13 dbSNP
rs768988047 14 dbSNP
rs375892457 15 dbSNP
rs746034624 23 dbSNP
rs1396486884 26 dbSNP
rs777148548 28 dbSNP
rs771354648 32 dbSNP
rs186118138 33 dbSNP
rs371257788 43 dbSNP
rs368039734 44 dbSNP
rs748790534 46 dbSNP
rs1352531508 57 dbSNP
rs567593770 61 dbSNP
rs913003858 63 dbSNP
rs954683584 75 dbSNP
rs1030660429 76 dbSNP
rs1490215732 78 dbSNP
rs1200152943 81 dbSNP
rs1271700295 87 dbSNP
rs1258624860 94 dbSNP
rs35791198 97 dbSNP
rs577946371 104 dbSNP
rs372957977 108 dbSNP
rs746384299 113 dbSNP
rs1285492884 114 dbSNP
rs1455653447 117 dbSNP
rs779434570 122 dbSNP
rs1299786581 126 dbSNP
rs1405038542 127 dbSNP
rs953907755 129 dbSNP
rs1029512483 136 dbSNP
rs1263826627 139 dbSNP
rs998055334 143 dbSNP
rs896969421 149 dbSNP
rs1337331844 156 dbSNP
rs539223841 157 dbSNP
rs904931231 160 dbSNP
rs1416324433 164 dbSNP
rs1338164432 165 dbSNP
rs575128830 166 dbSNP
rs1014170423 171 dbSNP
rs1223485225 174 dbSNP
rs1294129013 182 dbSNP
rs1479681453 183 dbSNP
rs1177186967 187 dbSNP
rs1251813507 195 dbSNP
rs896740604 197 dbSNP
rs773126527 199 dbSNP
rs1161005000 204 dbSNP
rs556827403 209 dbSNP
rs1384243467 216 dbSNP
rs56203737 219 dbSNP
rs938279599 222 dbSNP
rs878959010 224 dbSNP
rs1167739811 225 dbSNP
rs906770925 229 dbSNP
rs373836441 231 dbSNP
rs1047067440 237 dbSNP
rs538947624 240 dbSNP
rs567603525 241 dbSNP
rs945593323 243 dbSNP
rs1038361967 252 dbSNP
rs555486534 254 dbSNP
rs1247043702 256 dbSNP
rs751203074 261 dbSNP
rs1194163170 264 dbSNP
rs182863875 266 dbSNP
rs911302362 267 dbSNP
rs190620667 272 dbSNP
rs114172059 277 dbSNP
rs1335554670 279 dbSNP
rs1481875170 280 dbSNP
rs112516263 282 dbSNP
rs368350687 300 dbSNP
rs569514145 301 dbSNP
rs985093369 304 dbSNP
rs750371806 313 dbSNP
rs185854405 319 dbSNP
rs765195948 321 dbSNP
rs1355759964 323 dbSNP
rs1031988928 325 dbSNP
rs373949188 330 dbSNP
rs1269423829 340 dbSNP
rs60340844 341 dbSNP
rs1454334109 342 dbSNP
rs1304843833 367 dbSNP
rs1360053409 368 dbSNP
rs181234074 369 dbSNP
rs1214079323 379 dbSNP
rs528102016 380 dbSNP
rs1309334503 384 dbSNP
rs1015805141 386 dbSNP
rs1321206482 391 dbSNP
rs572287782 394 dbSNP
rs1462050876 397 dbSNP
rs1205929137 399 dbSNP
rs563821260 405 dbSNP
rs1240026590 421 dbSNP
rs1485369313 427 dbSNP
rs1005643727 430 dbSNP
rs1439432832 437 dbSNP
rs1013763325 439 dbSNP
rs896620349 443 dbSNP
rs1025915027 450 dbSNP
rs1175632414 458 dbSNP
rs1394593833 460 dbSNP
rs1429829089 469 dbSNP
rs1328500972 472 dbSNP
rs1470850322 488 dbSNP
rs879843936 499 dbSNP
rs1052883 500 dbSNP
rs1156604823 500 dbSNP
rs1430325135 511 dbSNP
rs1289657711 513 dbSNP
rs1002184144 521 dbSNP
rs1403114339 522 dbSNP
rs1283244443 524 dbSNP
rs1225867458 527 dbSNP
rs1168903459 528 dbSNP
rs575091527 533 dbSNP
rs1216136306 534 dbSNP
rs1046678075 535 dbSNP
rs1038413612 536 dbSNP
rs1198015425 537 dbSNP
rs1489639952 537 dbSNP
rs945615475 546 dbSNP
rs1376068756 556 dbSNP
rs942674050 557 dbSNP
rs763808419 561 dbSNP
rs189265159 581 dbSNP
rs935746842 582 dbSNP
rs775731523 583 dbSNP
rs925666150 584 dbSNP
rs1302685890 585 dbSNP
rs933181323 593 dbSNP
rs1436064296 596 dbSNP
rs923071817 597 dbSNP
rs985197099 606 dbSNP
rs1373070761 616 dbSNP
rs1224617563 627 dbSNP
rs1287753503 632 dbSNP
rs1221245367 638 dbSNP
rs987971449 640 dbSNP
rs1291916785 641 dbSNP
rs1179597847 646 dbSNP
rs932342442 646 dbSNP
rs1232169728 659 dbSNP
rs1470409500 660 dbSNP
rs935277735 661 dbSNP
rs925192794 665 dbSNP
rs114030133 672 dbSNP
rs185950526 678 dbSNP
rs1366336814 684 dbSNP
rs774779336 685 dbSNP
rs574659504 691 dbSNP
rs555704420 698 dbSNP
rs2824 699 dbSNP
rs762194843 705 dbSNP
rs984337992 707 dbSNP
rs566907811 710 dbSNP
rs1443411984 717 dbSNP
rs1253500127 720 dbSNP
rs558276490 721 dbSNP
rs960469510 725 dbSNP
rs1002235087 731 dbSNP
rs1193534331 733 dbSNP
rs1211583823 740 dbSNP
rs1354103316 742 dbSNP
rs1263786559 745 dbSNP
rs906581039 747 dbSNP
rs1351385969 751 dbSNP
rs1026261367 752 dbSNP
rs1009828684 753 dbSNP
rs892679856 763 dbSNP
rs1335551327 764 dbSNP
rs1435779965 765 dbSNP
rs529728173 765 dbSNP
rs745618643 765 dbSNP
rs1324553006 769 dbSNP
rs1407605476 770 dbSNP
rs1389165272 782 dbSNP
rs1480715096 783 dbSNP
rs1418863014 787 dbSNP
rs750024224 787 dbSNP
rs575924570 788 dbSNP
rs1413810461 789 dbSNP
rs1197379453 790 dbSNP
rs1052910 792 dbSNP
rs1469260927 793 dbSNP
rs1247094189 803 dbSNP
rs1006902211 816 dbSNP
rs370213668 817 dbSNP
rs1252269662 818 dbSNP
rs1213205522 822 dbSNP
rs1329926661 826 dbSNP
rs1436483888 829 dbSNP
rs1270019473 831 dbSNP
rs764604078 832 dbSNP
rs1269121309 833 dbSNP
rs569429461 834 dbSNP
rs763974908 835 dbSNP
rs934091628 837 dbSNP
rs182162812 841 dbSNP
rs1439026674 842 dbSNP
rs775450317 843 dbSNP
rs1325821256 844 dbSNP
rs1052731140 846 dbSNP
rs569209264 847 dbSNP
rs1305205531 859 dbSNP
rs1191259192 865 dbSNP
rs1241663970 868 dbSNP
rs932352358 873 dbSNP
rs1372000039 874 dbSNP
rs1280636159 879 dbSNP
rs1427772175 881 dbSNP
rs1445078610 882 dbSNP
rs1177667737 884 dbSNP
rs922301923 890 dbSNP
rs529561303 891 dbSNP
rs925212375 893 dbSNP
rs1317181978 894 dbSNP
rs746693895 895 dbSNP
rs947743633 898 dbSNP
rs1281336178 899 dbSNP
rs908478731 908 dbSNP
rs916256581 909 dbSNP
rs1400128603 914 dbSNP
rs1224019980 916 dbSNP
rs991826213 917 dbSNP
rs568635585 918 dbSNP
rs926454275 935 dbSNP
rs1177704822 936 dbSNP
rs960774051 939 dbSNP
rs112382780 940 dbSNP
rs1266839339 950 dbSNP
rs1255108227 954 dbSNP
rs112023993 955 dbSNP
rs962836355 957 dbSNP
rs372921867 966 dbSNP
rs1485879457 968 dbSNP
rs762475207 969 dbSNP
rs1281948402 978 dbSNP
rs1007124442 980 dbSNP
rs757891693 981 dbSNP
rs549207860 990 dbSNP
rs929155573 996 dbSNP
rs766948849 997 dbSNP
rs1405550139 1000 dbSNP
rs563784696 1009 dbSNP
rs545444461 1015 dbSNP
rs1333272844 1017 dbSNP
rs1260388838 1021 dbSNP
rs1030102642 1025 dbSNP
rs1001117159 1026 dbSNP
rs866113650 1031 dbSNP
rs529477028 1035 dbSNP
rs891913156 1038 dbSNP
rs1053177860 1041 dbSNP
rs1417737312 1042 dbSNP
rs749931793 1043 dbSNP
rs530530194 1044 dbSNP
rs1043524331 1050 dbSNP
rs1161275027 1052 dbSNP
rs1364471412 1055 dbSNP
rs1424675147 1058 dbSNP
rs948002276 1065 dbSNP
rs1394193313 1070 dbSNP
rs1390731870 1071 dbSNP
rs1357769846 1072 dbSNP
rs1296563987 1084 dbSNP
rs79523423 1087 dbSNP
rs541680693 1088 dbSNP
rs1040781112 1098 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166 , TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gaagacuGAGGUUCGGGUCa 5'
                 || | ||||||| 
Target 5' -------CUGC-AGCCCAGa 3'
 		1 - 12
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM4903825
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID14_NS
Location of target site NM_015103 | 3UTR | AACGUCCAGUUGGUCCUGCUGCCAAGAGCCCCGUGCAUCCAGGCGGCCAAGCACAAACUGGGGGAGAGGAGGCCGCCAGCCCGGAGGCUGCAGCCCAGAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000393239.1 | 3UTR | AAACUCUACCUCAUCCACACUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000393239.1 | 3UTR | CUGCAGCCCAGAAACUCUACCUCAUCCACACUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
68 hsa-miR-378g Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT444739 SMYD1 SET and MYND domain containing 1 2 2
MIRT456104 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT458683 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT465802 TMEM91 transmembrane protein 91 2 2
MIRT470843 PLXND1 plexin D1 2 2
MIRT497263 GRK6 G protein-coupled receptor kinase 6 2 2
MIRT497674 SYNGR1 synaptogyrin 1 2 2
MIRT498218 TLN2 talin 2 2 2
MIRT498309 BCL11B B-cell CLL/lymphoma 11B 2 2
MIRT504046 TOMM5 translocase of outer mitochondrial membrane 5 2 2
MIRT518196 CLEC4E C-type lectin domain family 4 member E 2 2
MIRT533143 WNT10A Wnt family member 10A 2 2
MIRT533540 TPR translocated promoter region, nuclear basket protein 2 2
MIRT533679 TMEM86A transmembrane protein 86A 2 2
MIRT540892 SRSF9 serine and arginine rich splicing factor 9 2 2
MIRT541329 G3BP1 G3BP stress granule assembly factor 1 2 2
MIRT541850 PLIN5 perilipin 5 2 2
MIRT551431 F2 coagulation factor II, thrombin 2 2
MIRT552105 PPP1R1A protein phosphatase 1 regulatory inhibitor subunit 1A 2 2
MIRT564912 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 2
MIRT568605 ACVR2A activin A receptor type 2A 2 2
MIRT572604 PAPLN papilin, proteoglycan like sulfated glycoprotein 2 2
MIRT574234 DMRT2 doublesex and mab-3 related transcription factor 2 2 2
MIRT575688 Map1b microtubule-associated protein 1B 2 2
MIRT576643 Mill2 MHC I like leukocyte 2 1 1
MIRT609877 RAD54L2 RAD54 like 2 2 4
MIRT610057 MYBPC1 myosin binding protein C, slow type 2 2
MIRT610791 KLK2 kallikrein related peptidase 2 2 2
MIRT617175 GOSR2 golgi SNAP receptor complex member 2 2 2
MIRT617707 RUSC2 RUN and SH3 domain containing 2 2 2
MIRT620577 WBSCR27 methyltransferase like 27 2 4
MIRT622657 POU2F3 POU class 2 homeobox 3 2 4
MIRT624561 BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 2 2
MIRT634255 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT634677 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT635254 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT637081 SELPLG selectin P ligand 2 2
MIRT639021 AAK1 AP2 associated kinase 1 2 2
MIRT640396 ZNF785 zinc finger protein 785 2 2
MIRT642441 CLUAP1 clusterin associated protein 1 2 2
MIRT645666 ADK adenosine kinase 2 2
MIRT646083 MGST3 microsomal glutathione S-transferase 3 2 2
MIRT650513 UFM1 ubiquitin fold modifier 1 2 2
MIRT652474 TMEM181 transmembrane protein 181 2 2
MIRT652584 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT654763 PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha 2 2
MIRT655200 PHAX phosphorylated adaptor for RNA export 2 2
MIRT658353 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT661820 PRPSAP1 phosphoribosyl pyrophosphate synthetase associated protein 1 2 2
MIRT662190 MEI1 meiotic double-stranded break formation protein 1 2 2
MIRT664375 CYB5A cytochrome b5 type A 2 2
MIRT665025 ELK1 ELK1, ETS transcription factor 2 2
MIRT666492 SBNO1 strawberry notch homolog 1 2 2
MIRT668480 EXOSC2 exosome component 2 2 2
MIRT682768 TMEM120B transmembrane protein 120B 2 2
MIRT689628 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2 2
MIRT691846 OSCAR osteoclast associated, immunoglobulin-like receptor 2 2
MIRT696490 COX6B1 cytochrome c oxidase subunit 6B1 2 2
MIRT712480 FSTL3 follistatin like 3 2 2
MIRT712780 ZNF154 zinc finger protein 154 2 2
MIRT716607 MPPED1 metallophosphoesterase domain containing 1 2 2
MIRT719357 ITPKB inositol-trisphosphate 3-kinase B 2 2
MIRT719739 SLC39A11 solute carrier family 39 member 11 2 2
MIRT722569 C1orf95 stum, mechanosensory transduction mediator homolog 2 2
MIRT722838 C17orf102 chromosome 17 open reading frame 102 2 2
MIRT733138 LINC00963 long intergenic non-protein coding RNA 963 3 0
MIRT733139 CHI3L1 chitinase 3 like 1 3 0
MIRT736944 TARBP2 TARBP2, RISC loading complex RNA binding subunit 2 0
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-378g Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-378g Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-378g Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-378g Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-378g Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (500nM)
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (500nM)
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (2uM)
hsa-miR-378g Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (2uM)
hsa-miR-378g Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (AsPC-1)
hsa-miR-378g Trametinib 11707110 NSC758246 approved sensitive High Melanoma cell line
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line
hsa-miR-378g Dabrafenib + Trametinib sensitive High Melanoma cell line
hsa-miR-378g Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line
hsa-mir-378g Decitabine 451668 approved sensitive tissue (esopheageal cancer)
hsa-miR-378g Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-378g Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-378g Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-378g Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-378g Tripterygium wilfordii Hook F resistant tissue
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM36)
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-378g Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-378g Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-378g Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-378g Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR3)
hsa-miR-378g Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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