pre-miRNA Information
pre-miRNA hsa-mir-4477a   
Genomic Coordinates chr9: 41233755 - 41233835
Description Homo sapiens miR-4477a stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4477a
Sequence 48| CUAUUAAGGACAUUUGUGAUUC |69
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1281813060 1 dbSNP
rs1352899679 1 dbSNP
rs1283566158 2 dbSNP
rs1236244724 4 dbSNP
rs75019967 4 dbSNP
rs1348124293 5 dbSNP
rs34026740 8 dbSNP
rs1288237115 9 dbSNP
rs71262206 10 dbSNP
rs1355759977 11 dbSNP
rs1300249508 16 dbSNP
rs1328879592 18 dbSNP
rs139133717 20 dbSNP
Putative Targets

Gene Information
Gene Symbol PLIN3   
Synonyms M6PRBP1, PP17, TIP47
Description perilipin 3
Transcript NM_001164189   
Other Transcripts NM_001164194 , NM_005817   
Expression
Putative miRNA Targets on PLIN3
3'UTR of PLIN3
(miRNA target sites are highlighted)
>PLIN3|NM_001164189|3'UTR
   1 GGGGAGAGGAGAGGACTCAGCGGGCCCCGTCTCTATAATGCAGCTGTGCTCTGGAGTCCTCAACCCGGGGCTCATTTCAA
  81 ACTTATTTTCTAGCCACTCCTCCCAGCTCTTCTGTGCTGTCCACTTGGGAAGCTAAGGCTCTCAAAACGGGCATCACCCA
 161 GTTGACCCATCTCTCAGCCTCTCTGAGCTTGGAAGAAGCCTGTTCTGAGCCTCACCCTATCAGTCAGTAGAGAGAGATGT
 241 CCAGAAAAAATATCTTTCAGGAAAGTTCTCCCCTGCAGAATTTTTTTTCCTTGTTAAATATCAGGAATATAGGCCGGGTG
 321 CGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCGGAACACCTGAGGTCAGGTGTTCGAGACCAGC
 401 CAGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAAAAATGAGCCGGGCATGGTAGCAGGTGTCTGTTATC
 481 CCAGTTAGGAGGCTGAGGCAAGAGAATCTCTTGAACCTGAGAGGCGGAGGTTGCAGTGAGCCAAGATCGCGCCATTGCAC
 561 TCCAGCCTGGGGGACAAGAGTGAGACTTAGTCTCAAAAAAAAAAAAAAAGAAAAAAAAATCAGGGATATAGTTCATATCC
 641 CACTTCTTTGTTTACACCGATGTCCCTGAATATCAGCCTGTAGCTAATGGACTTGGGATTTCTGGTCTAAGTGGGCCTCC
 721 TGGGGATGGGGTGGTACACTGAGCTTCTGAGCCTCATTGTAGAGTAGAAAGGTACTGGGGCCTGTGTGGTAAGCCTTGTT
 801 GAAATGCTCTGGTATTCAGTATTGCCTTAATAAACTTCACCCACAACTGCATACAGGCAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cuuAGUGUUUACAGGAAUUAUc 5'
             |||  | || |||||||| 
Target 5' tatTCAGTATTG-CCTTAATAa 3'
813 - 833 158.00 -7.70
2
miRNA  3' cuuaGUGUUUACA-GGAAUUAUc 5'
              ||| :|||| ||| |||| 
Target 5' tttaCACCGATGTCCCTGAATAt 3'
651 - 673 138.00 -11.70
3
miRNA  3' cuuagUGUUUACA---GGAAUUAuc 5'
               ||||: ||    ||||:|  
Target 5' gggggACAAGAGTGAGACTTAGTct 3'
569 - 593 117.00 -8.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26989487 2 COSMIC
COSN30489691 3 COSMIC
COSN30183883 4 COSMIC
COSN30156434 6 COSMIC
COSN31510647 14 COSMIC
COSN30156911 25 COSMIC
COSN30168457 25 COSMIC
COSN31547337 38 COSMIC
COSN30184752 46 COSMIC
COSN30475499 58 COSMIC
COSN13816719 67 COSMIC
COSN5852288 90 COSMIC
COSN1770020 137 COSMIC
COSN1770019 158 COSMIC
COSN16581988 316 COSMIC
COSN7447340 608 COSMIC
COSN7447339 609 COSMIC
COSN28717895 610 COSMIC
COSN31577625 658 COSMIC
COSN31533420 818 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs747726786 1 dbSNP
rs1431912242 3 dbSNP
rs1157587706 6 dbSNP
rs780858613 18 dbSNP
rs112206231 21 dbSNP
rs186210004 22 dbSNP
rs758404762 24 dbSNP
rs750442254 25 dbSNP
rs778826060 27 dbSNP
rs368144778 28 dbSNP
rs374670367 29 dbSNP
rs759686146 30 dbSNP
rs751658341 31 dbSNP
rs766506955 34 dbSNP
rs371801808 35 dbSNP
rs1376361566 39 dbSNP
rs770316938 43 dbSNP
rs1453007870 44 dbSNP
rs1027437962 45 dbSNP
rs1319027237 50 dbSNP
rs892151148 52 dbSNP
rs1416944860 55 dbSNP
rs1318896833 59 dbSNP
rs528081317 62 dbSNP
rs1388335678 66 dbSNP
rs1031987747 67 dbSNP
rs1000620527 70 dbSNP
rs1366183986 72 dbSNP
rs1218660990 77 dbSNP
rs572851184 80 dbSNP
rs1325874514 82 dbSNP
rs897516152 83 dbSNP
rs1240277716 90 dbSNP
rs1044941541 93 dbSNP
rs1447364956 96 dbSNP
rs558251955 103 dbSNP
rs775150583 104 dbSNP
rs1244853231 106 dbSNP
rs1477660684 109 dbSNP
rs772207711 114 dbSNP
rs1274069745 123 dbSNP
rs868106859 130 dbSNP
rs377239213 148 dbSNP
rs907474414 149 dbSNP
rs1045923072 156 dbSNP
rs948929166 162 dbSNP
rs1332919137 165 dbSNP
rs1157916192 169 dbSNP
rs1293113465 173 dbSNP
rs1215510664 185 dbSNP
rs916057220 192 dbSNP
rs1054569582 210 dbSNP
rs146452452 213 dbSNP
rs542612547 217 dbSNP
rs771627027 219 dbSNP
rs1429441020 222 dbSNP
rs745923373 225 dbSNP
rs1049009155 238 dbSNP
rs181239407 238 dbSNP
rs766485939 244 dbSNP
rs1459590029 249 dbSNP
rs1393259458 253 dbSNP
rs1481784049 254 dbSNP
rs1180898878 268 dbSNP
rs1363959025 273 dbSNP
rs1170963782 280 dbSNP
rs1160613481 281 dbSNP
rs1164771391 289 dbSNP
rs1411377894 289 dbSNP
rs1412101048 289 dbSNP
rs1368074716 291 dbSNP
rs56058268 299 dbSNP
rs1417310747 309 dbSNP
rs922002358 313 dbSNP
rs965993929 315 dbSNP
rs1444667998 316 dbSNP
rs1282693912 320 dbSNP
rs569429466 321 dbSNP
rs1253752129 322 dbSNP
rs1195560475 325 dbSNP
rs1293839038 329 dbSNP
rs1434241582 331 dbSNP
rs1467356537 342 dbSNP
rs913376198 343 dbSNP
rs1265081908 346 dbSNP
rs1205667840 352 dbSNP
rs986035412 364 dbSNP
rs1271542160 365 dbSNP
rs372935329 368 dbSNP
rs1372334271 369 dbSNP
rs1236573308 373 dbSNP
rs1444389215 385 dbSNP
rs1032020186 389 dbSNP
rs190098146 391 dbSNP
rs1023789833 392 dbSNP
rs1397274383 401 dbSNP
rs537340606 405 dbSNP
rs1438069054 415 dbSNP
rs1382379994 419 dbSNP
rs551000243 422 dbSNP
rs1298334275 423 dbSNP
rs1444132391 429 dbSNP
rs962116185 431 dbSNP
rs1352508775 437 dbSNP
rs896321780 439 dbSNP
rs1036128941 448 dbSNP
rs1004757574 449 dbSNP
rs184511985 455 dbSNP
rs1049084889 457 dbSNP
rs1003165944 459 dbSNP
rs922062517 462 dbSNP
rs1396802191 479 dbSNP
rs1175679967 480 dbSNP
rs1452587727 482 dbSNP
rs906207290 490 dbSNP
rs557892874 491 dbSNP
rs1040845578 502 dbSNP
rs749785698 517 dbSNP
rs1013109321 524 dbSNP
rs1374217570 525 dbSNP
rs868153958 526 dbSNP
rs1170907677 530 dbSNP
rs1405535299 535 dbSNP
rs1470442696 543 dbSNP
rs1266959230 544 dbSNP
rs1338396926 548 dbSNP
rs113906234 549 dbSNP
rs868543316 550 dbSNP
rs1231575059 551 dbSNP
rs1204868528 555 dbSNP
rs936149348 557 dbSNP
rs1273766654 560 dbSNP
rs1283003447 561 dbSNP
rs1205151854 562 dbSNP
rs1265898986 565 dbSNP
rs1463821240 568 dbSNP
rs1204974137 569 dbSNP
rs1262971849 569 dbSNP
rs988944110 569 dbSNP
rs1196795270 570 dbSNP
rs957645061 573 dbSNP
rs1178809154 575 dbSNP
rs1410113825 576 dbSNP
rs1452716047 580 dbSNP
rs566928954 592 dbSNP
rs1346451197 593 dbSNP
rs1031526794 594 dbSNP
rs1225161732 595 dbSNP
rs1302526911 595 dbSNP
rs1370701513 596 dbSNP
rs903267631 596 dbSNP
rs546604818 597 dbSNP
rs1345563849 602 dbSNP
rs1297452191 604 dbSNP
rs1415166274 607 dbSNP
rs1377203824 608 dbSNP
rs1310934798 609 dbSNP
rs1286057082 610 dbSNP
rs1315981837 610 dbSNP
rs199891296 610 dbSNP
rs560562572 610 dbSNP
rs879239592 610 dbSNP
rs1432964230 611 dbSNP
rs1377180006 612 dbSNP
rs1041820318 613 dbSNP
rs139763716 613 dbSNP
rs574041588 613 dbSNP
rs1201751622 614 dbSNP
rs60537156 614 dbSNP
rs1406054126 615 dbSNP
rs1181912043 616 dbSNP
rs911881333 616 dbSNP
rs1486168365 617 dbSNP
rs986067845 618 dbSNP
rs536279035 619 dbSNP
rs1456235939 620 dbSNP
rs202026028 620 dbSNP
rs778807956 620 dbSNP
rs979145796 620 dbSNP
rs969448279 621 dbSNP
rs192634463 628 dbSNP
rs200959535 632 dbSNP
rs531225623 634 dbSNP
rs1372105700 640 dbSNP
rs1209301863 641 dbSNP
rs1308753396 644 dbSNP
rs920495987 646 dbSNP
rs567197402 649 dbSNP
rs1013769504 650 dbSNP
rs1224769358 655 dbSNP
rs1240550185 656 dbSNP
rs1314835170 658 dbSNP
rs973653306 659 dbSNP
rs1233690682 661 dbSNP
rs1253008780 666 dbSNP
rs961866576 677 dbSNP
rs960403962 692 dbSNP
rs1055943 702 dbSNP
rs981819273 703 dbSNP
rs970396536 709 dbSNP
rs1023275878 715 dbSNP
rs565343291 723 dbSNP
rs1353389938 724 dbSNP
rs1011838744 725 dbSNP
rs894725745 728 dbSNP
rs1299518889 737 dbSNP
rs1376586300 739 dbSNP
rs1033224973 741 dbSNP
rs1055949 747 dbSNP
rs1384126847 749 dbSNP
rs1385561387 751 dbSNP
rs1000808932 753 dbSNP
rs1455349433 754 dbSNP
rs35425325 767 dbSNP
rs183778347 770 dbSNP
rs1475754387 772 dbSNP
rs1027509127 774 dbSNP
rs1460154021 779 dbSNP
rs944752866 780 dbSNP
rs1202753320 782 dbSNP
rs890523466 787 dbSNP
rs1243549736 796 dbSNP
rs1055954 809 dbSNP
rs1418792693 812 dbSNP
rs542722981 824 dbSNP
rs528943381 825 dbSNP
rs931968465 831 dbSNP
rs1263044692 832 dbSNP
rs758020584 840 dbSNP
rs781437631 843 dbSNP
rs1337045254 848 dbSNP
rs113774729 852 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177612. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_3_2 PAR-CLIP data was present in ERX177624. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_4_2 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000221957.4 | 3UTR | CCUUAAUAAACUUCACCCACAACUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
134 hsa-miR-4477a Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055843 PLEKHA1 pleckstrin homology domain containing A1 2 10
MIRT061259 AMOTL1 angiomotin like 1 2 4
MIRT071895 BTF3L4 basic transcription factor 3 like 4 2 6
MIRT076933 MLLT6 MLLT6, PHD finger containing 2 2
MIRT078652 ICT1 mitochondrial ribosomal protein L58 2 2
MIRT083633 PRNP prion protein 2 2
MIRT091629 RPL15 ribosomal protein L15 2 4
MIRT107076 PPP6C protein phosphatase 6 catalytic subunit 2 2
MIRT111191 TRIM33 tripartite motif containing 33 2 2
MIRT114515 ARF6 ADP ribosylation factor 6 2 2
MIRT175250 PSAT1 phosphoserine aminotransferase 1 2 4
MIRT175430 ACSL4 acyl-CoA synthetase long chain family member 4 2 2
MIRT178687 FAM102B family with sequence similarity 102 member B 2 2
MIRT189771 CDADC1 cytidine and dCMP deaminase domain containing 1 2 2
MIRT229450 RPL10 ribosomal protein L10 2 2
MIRT244899 PHF6 PHD finger protein 6 2 2
MIRT249189 AKIRIN1 akirin 1 2 8
MIRT261134 TRIM8 tripartite motif containing 8 2 2
MIRT275561 ZIC5 Zic family member 5 2 4
MIRT275652 ABHD13 abhydrolase domain containing 13 2 2
MIRT288082 UTP18 UTP18, small subunit processome component 2 2
MIRT303605 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 2
MIRT307924 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT316787 FOXC1 forkhead box C1 2 2
MIRT326910 SCML2 Scm polycomb group protein like 2 2 2
MIRT327713 SPIN4 spindlin family member 4 2 2
MIRT331632 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT342506 TMOD3 tropomodulin 3 2 4
MIRT354470 LRRC58 leucine rich repeat containing 58 2 2
MIRT378711 TRIM24 tripartite motif containing 24 2 2
MIRT407462 YDJC YdjC chitooligosaccharide deacetylase homolog 2 2
MIRT408226 SMAD5 SMAD family member 5 2 4
MIRT441824 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT442783 CHD8 chromodomain helicase DNA binding protein 8 2 2
MIRT443184 NHS NHS actin remodeling regulator 2 4
MIRT447615 CUL3 cullin 3 2 2
MIRT450156 DSEL dermatan sulfate epimerase-like 2 2
MIRT454801 NEDD9 neural precursor cell expressed, developmentally down-regulated 9 2 2
MIRT463050 ZNF644 zinc finger protein 644 2 2
MIRT467400 SOCS3 suppressor of cytokine signaling 3 2 2
MIRT468174 SGMS1 sphingomyelin synthase 1 2 2
MIRT468949 RPS14 ribosomal protein S14 2 6
MIRT469835 R3HDM4 R3H domain containing 4 2 2
MIRT470724 POFUT1 protein O-fucosyltransferase 1 2 2
MIRT470902 PLIN3 perilipin 3 2 2
MIRT472467 NAPG NSF attachment protein gamma 2 12
MIRT472602 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT492350 SEMA7A semaphorin 7A (John Milton Hagen blood group) 2 2
MIRT493840 FOXN3 forkhead box N3 2 4
MIRT496318 DOCK9 dedicator of cytokinesis 9 2 2
MIRT500159 CLEC2D C-type lectin domain family 2 member D 2 8
MIRT500535 XPO4 exportin 4 2 4
MIRT503916 FBXL13 F-box and leucine rich repeat protein 13 2 4
MIRT504003 SAT1 spermidine/spermine N1-acetyltransferase 1 2 4
MIRT505647 SHMT1 serine hydroxymethyltransferase 1 2 4
MIRT506574 MIER3 MIER family member 3 2 4
MIRT506945 HS3ST3B1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 2 4
MIRT508196 RPS19 ribosomal protein S19 2 6
MIRT511417 HSPA13 heat shock protein family A (Hsp70) member 13 2 4
MIRT512326 ACTB actin beta 2 4
MIRT515376 RPL7 ribosomal protein L7 2 2
MIRT520422 TUBG1 tubulin gamma 1 2 4
MIRT524844 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT526320 UGT2A1 UDP glucuronosyltransferase family 2 member A1 complex locus 2 2
MIRT526561 UGT2A2 UDP glucuronosyltransferase family 2 member A2 2 2
MIRT528027 FEZ2 fasciculation and elongation protein zeta 2 2 2
MIRT529874 RBM43 RNA binding motif protein 43 2 2
MIRT530826 CLEC4D C-type lectin domain family 4 member D 2 2
MIRT531334 GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 2 2
MIRT532068 CCNB1 cyclin B1 2 4
MIRT532870 ZNF566 zinc finger protein 566 2 2
MIRT535580 NUP35 nucleoporin 35 2 2
MIRT537644 ERGIC2 ERGIC and golgi 2 2 4
MIRT537725 ELAVL2 ELAV like RNA binding protein 2 2 2
MIRT538894 BRI3BP BRI3 binding protein 2 2
MIRT538945 BMP2K BMP2 inducible kinase 2 2
MIRT540703 PDPK1 3-phosphoinositide dependent protein kinase 1 2 4
MIRT543210 TMEM117 transmembrane protein 117 2 3
MIRT543357 LYRM2 LYR motif containing 2 2 2
MIRT544905 CLSPN claspin 2 2
MIRT545532 ARF3 ADP ribosylation factor 3 2 2
MIRT546446 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT546882 PURB purine rich element binding protein B 2 4
MIRT547440 MED13 mediator complex subunit 13 2 2
MIRT548027 GOLIM4 golgi integral membrane protein 4 2 2
MIRT548673 CRNKL1 crooked neck pre-mRNA splicing factor 1 2 2
MIRT550435 LLGL2 LLGL2, scribble cell polarity complex component 2 2
MIRT551850 RPS3 ribosomal protein S3 2 2
MIRT556072 MRFAP1 Morf4 family associated protein 1 2 2
MIRT556554 LIMS1 LIM zinc finger domain containing 1 2 2
MIRT557132 HOXA13 homeobox A13 2 2
MIRT557875 FEM1B fem-1 homolog B 2 4
MIRT558146 ELK4 ELK4, ETS transcription factor 2 2
MIRT558862 CD2AP CD2 associated protein 2 2
MIRT558884 CCNE1 cyclin E1 2 4
MIRT558907 CBX5 chromobox 5 2 2
MIRT559175 BRAP BRCA1 associated protein 2 2
MIRT560860 GAL3ST3 galactose-3-O-sulfotransferase 3 2 2
MIRT561729 PPIF peptidylprolyl isomerase F 2 2
MIRT564024 CEBPB CCAAT/enhancer binding protein beta 2 2
MIRT564366 TRMT5 tRNA methyltransferase 5 2 2
MIRT564609 ZNF703 zinc finger protein 703 2 2
MIRT565494 AZF1 azoospermia factor 1 2 2
MIRT565577 SLC6A8 solute carrier family 6 member 8 2 2
MIRT566947 LEPROT leptin receptor overlapping transcript 2 2
MIRT567293 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT567308 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT568048 CHSY1 chondroitin sulfate synthase 1 2 2
MIRT571807 PHF19 PHD finger protein 19 2 2
MIRT609234 RBM23 RNA binding motif protein 23 2 2
MIRT610328 SSX5 SSX family member 5 2 2
MIRT611428 UGT8 UDP glycosyltransferase 8 2 4
MIRT611709 SLFN13 schlafen family member 13 2 2
MIRT612069 CEP135 centrosomal protein 135 2 4
MIRT617676 JRKL JRK like 2 2
MIRT623684 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT635634 PRR15L proline rich 15 like 2 2
MIRT636422 MBOAT2 membrane bound O-acyltransferase domain containing 2 2 2
MIRT637011 GPATCH11 G-patch domain containing 11 2 2
MIRT644150 C4orf3 chromosome 4 open reading frame 3 2 2
MIRT648562 MEMO1 mediator of cell motility 1 2 2
MIRT650752 WNT16 Wnt family member 16 2 2
MIRT651914 UEVLD UEV and lactate/malate dehyrogenase domains 2 2
MIRT653556 SLC38A7 solute carrier family 38 member 7 2 2
MIRT692277 XRN2 5'-3' exoribonuclease 2 2 2
MIRT697650 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT703876 ERCC6 ERCC excision repair 6, chromatin remodeling factor 2 2
MIRT704615 CLIP1 CAP-Gly domain containing linker protein 1 2 2
MIRT708562 BBOX1 gamma-butyrobetaine hydroxylase 1 2 2
MIRT709614 KBTBD6 kelch repeat and BTB domain containing 6 2 2
MIRT712955 SGCD sarcoglycan delta 2 2
MIRT713502 DCAF17 DDB1 and CUL4 associated factor 17 2 2
MIRT720239 GPBP1 GC-rich promoter binding protein 1 2 2
MIRT724255 GLUD1 glutamate dehydrogenase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4477a Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-4477a Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-4477a Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)

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