miRTarBase - #MIRT471090


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pre-miRNA Information
pre-miRNA hsa-mir-302b   
Genomic Coordinates chr4: 112648485 - 112648557
Description Homo sapiens miR-302b stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-302b-5p
Sequence 11| ACUUUAACAUGGAAGUGCUUUC |32
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN8489942 10 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs771747691 1 dbSNP
rs1413992790 2 dbSNP
rs1287454726 3 dbSNP
rs1407802102 5 dbSNP
rs556661625 8 dbSNP
rs114318553 9 dbSNP
rs183105707 12 dbSNP
rs759066554 13 dbSNP
rs1338196516 15 dbSNP
Putative Targets

Gene Information
Gene Symbol PIK3C2B   
Synonyms C2-PI3K
Description phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
Transcript NM_002646   
Expression
Putative miRNA Targets on PIK3C2B
3'UTR of PIK3C2B
(miRNA target sites are highlighted)		 
>PIK3C2B|NM_002646|3'UTR
   1 GCCCAGCAGAGCCACCACCCAGCATCCCAGGCTGGTGGCAGGAGCTGGGGGAGAGGACTCTCCCCTGTGAGACTCCTCCT
  81 TGTGAAGGGCCAGGGCCCTGGGCAGGCCTCCAGCTCGGTCCAGGTGATTCTGGCCTCTGTGGTAGGAGGCAGGGAGAGTA
 161 AGACATGCTCTGCTGTCTCTTCCTCTGGAGACTGAACTTGGGTTGGTTGTGATGAGCAGCCCCTTGGAGGCTGTGAGGTT
 241 GCAGCAAAGTTTTAAGTTTACCTTGTGTCAAGGGAGCAATGCTTGGTTTGGGGAGTGTGTGGGGTGGGCTGTATGAAGTA
 321 GCATTTTGGGGGTGGGTGGGTGGATATCTTAATTTTTATTTTTAAAAAATGAAATAGTGATGTTGTCCTAACTGGGACAG
 401 GAAGCCTTGCGAGAAGGGACGTACCTATGCCCCAGAAGGCAAGAGAGGAAGACTATTTGGACTTTTTGTATGATTAAGGT
 481 TCTTATTGGACTTTTCCCTAGGTTTTTTTTTTTTGTTATTGTTGTTGTTGTTTCGTTTTCTAGCTATAGGAACTATCTGG
 561 GGAGGGGCCCAGTGGGTCCTCGGCCAGAGCCCTCTCTAAGGACAGGTTGGGGAGGGTTGGGGAGGGCTGCCTGTGCTGGA
 641 CTGAGGCTTGTGCCACTGGGCCTTTCTGATTTTGCCTCCAAAGGAGAGCGCTGTGATACCTACATGTGTAAGGAAGGGCC
 721 TTCCGTATTGGGGTTCTGCCAAGGACCCGTATTCAGGGACCCATGCTCTTTTGGGGGGACTTTTCCTCTTGTCTTCCCTA
 801 CTTTATTAGGACTTGCCCTGAATACCATTTTCTACCCCTTGCCCCTCCATTCTCCTGGCCCTTCTGGGGGTCAGCTGGTC
 881 TCTATGAATATGCTGGGGGTGCTTCCCCATAGGTCTCTCCCTTCATTTGTCTCTGGTGGGACAAAATACTGACTCAGTCC
 961 TTAGATGTAGTTTCACCCAAGAGCATCTTGGCCCTGGGAAGAGGTCCCTAGGCTGCAGATGCTACTGACTGCTTGCTAGG
1041 TAGCCTCTGGAAAGCATTCCCCATCCATCACTCCCCACTTCTTTCTGCTGTGCTGCTTCCCTCCCAAACTCCATTTCTGT
1121 CACCCTTTTTATAAGACTTTTCCTCATTCTGTGGGGCCATAAACCTATTTAGTCTGGAGCCAAAGGGATGCCCTATCTGA
1201 AGGAAAGGGGCATGGGGTGGGGGATTCCATCAAAACTGTTGTTTTTTGCCCCATGATTTTTCTTTGGTCAGTAGGAGGCT
1281 GGATTGGAGTGGTGATTATTCCCCTGGAGCTAAGCTCAGGAGCCCGAAGGGAGAGACTGAGACTGACTCCCTTATCTCTT
1361 CATATTCTTTATTCCCTACCAGATGGATTTTTTTTTTTTTTTTTGGAGACGGAGTCTCGCCCTGTCGCCAGGCTGGAGTG
1441 TAGTGGCATGATCTCGACTCACTGCAAAATCTGCCTCCCGGGTTCAAGCGATTCTCCTACCTCAGCCTCCCGAGTAGCTG
1521 GGATTACAGGCATGTGCCACCACGCCAAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGAT
1601 GGTCTCGATCTCTTGACCTCGTGATCTGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCC
1681 CGCCCCAGATGGATTTTACATTTGCTCTTTTGTGTTTCGCTCCAAAGGGTTGTCTTCCTCGCCAAAAGGAGGGAGGGACT
1761 TTGAATTTGATATGAATCTTTAAAACCAGAATTGGCTGGATATTTCCCATGATTGGGAAAAGAGTGAAATGAGGACATTC
1841 TGTAAACTGTCCCTCCCTAATTCCAAGGATCAGAAACTCCCCGTTTTGCTGACTCATTCCATAACTGGAGAAAGAAGCTC
1921 CATTGACCGAAGCCACAGGGCAGCATGGAAGTTTAAATTTTCTCTAAAATTAAAATGCCAAGGATAAAGCTGGCTGCTTC
2001 CAGGAGGGGGAAGAGGAGTGGGGAGTGGGCGGTGAAACTTTTCCAGATGAACGGACCATAAATGTGTTACTGGCTTTGTG
2081 CCTGTAGCTCATTTTATTATGACCTATATGCTCCTGATTTAAAGAGATCTGTGTACTGTTTACTTCCCACTTCCCAGAAT
2161 CCCTTGTATCTCCTTTCTCGGGAATTGTATTTTCTAATAAATGACATTTGAGAAAAAAATGA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuuuCGUGAAGGUACAAUUUCa 5'
              || || ||: ||| ||| 
Target 5' atctGC-CTCCCGGGTTCAAGc 3'
 1469 - 1489 125.00 -8.80
2 
miRNA  3' cuUUCGUGA--AGGUACAAUUUCa 5'
            :|| |||  ||| ||| ||:| 
Target 5' gtGAG-ACTCCTCCTTGTGAAGGg 3'
 67 - 89 117.00 -7.90
3 
miRNA  3' cuuucGUGAAGGUACA-AUUUCa 5'
               :|| | ||||| |||:| 
Target 5' tgtgaTACCTACATGTGTAAGGa 3'
 692 - 714 117.00 -7.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN32064111 28 COSMIC
COSN30486803 63 COSMIC
COSN31496584 79 COSMIC
COSN31533601 79 COSMIC
COSN30754411 88 COSMIC
COSN30509334 100 COSMIC
COSN30477361 106 COSMIC
COSN26989038 111 COSMIC
COSN30152854 130 COSMIC
COSN30523033 130 COSMIC
COSN24297888 131 COSMIC
COSN31509936 137 COSMIC
COSN30489381 154 COSMIC
COSN30157412 167 COSMIC
COSN31588163 336 COSMIC
COSN31588203 337 COSMIC
COSN23769544 451 COSMIC
COSN27198161 502 COSMIC
COSN20095844 503 COSMIC
COSN204155 518 COSMIC
COSN25903798 522 COSMIC
COSN9024801 661 COSMIC
COSN20213625 671 COSMIC
COSN31514963 690 COSMIC
COSN26669990 724 COSMIC
COSN31572752 725 COSMIC
COSN30539429 781 COSMIC
COSN32062830 838 COSMIC
COSN31518134 845 COSMIC
COSN6019663 1168 COSMIC
COSN9057199 1186 COSMIC
COSN31556875 1272 COSMIC
COSN30172514 2034 COSMIC
COSN18934211 2096 COSMIC
COSN7198918 2133 COSMIC
COSN31590559 2180 COSMIC
COSN30172519 2210 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs747145855 4 dbSNP
rs1039763818 11 dbSNP
rs1355285725 13 dbSNP
rs1438433695 18 dbSNP
rs1280695318 20 dbSNP
rs778814155 20 dbSNP
rs1216240719 26 dbSNP
rs754855079 28 dbSNP
rs1040606553 29 dbSNP
rs370055028 33 dbSNP
rs914721347 35 dbSNP
rs375764799 37 dbSNP
rs1296062583 43 dbSNP
rs1443722473 45 dbSNP
rs201442246 48 dbSNP
rs930769846 57 dbSNP
rs1306269594 59 dbSNP
rs17847769 60 dbSNP
rs931709321 61 dbSNP
rs1384372444 62 dbSNP
rs575066961 66 dbSNP
rs919360467 67 dbSNP
rs1475049100 68 dbSNP
rs570618115 71 dbSNP
rs921724766 73 dbSNP
rs976149218 74 dbSNP
rs1354601014 76 dbSNP
rs1331545395 77 dbSNP
rs535230764 78 dbSNP
rs4403681 83 dbSNP
rs907539091 87 dbSNP
rs773931352 89 dbSNP
rs1476366156 91 dbSNP
rs1406108478 92 dbSNP
rs771774949 93 dbSNP
rs1227906146 94 dbSNP
rs1470586003 95 dbSNP
rs763503821 101 dbSNP
rs776170355 102 dbSNP
rs770160575 103 dbSNP
rs746265739 116 dbSNP
rs17847770 117 dbSNP
rs571694970 118 dbSNP
rs1430654624 123 dbSNP
rs1267896476 124 dbSNP
rs1346584173 128 dbSNP
rs747837347 133 dbSNP
rs1222848590 134 dbSNP
rs61758021 135 dbSNP
rs777785152 142 dbSNP
rs969611637 146 dbSNP
rs372997267 148 dbSNP
rs1327123392 153 dbSNP
rs1463388071 156 dbSNP
rs1343788769 158 dbSNP
rs200312111 161 dbSNP
rs779905773 162 dbSNP
rs755925586 168 dbSNP
rs1034473351 170 dbSNP
rs1240405817 173 dbSNP
rs1003378493 175 dbSNP
rs1191864221 177 dbSNP
rs1479072155 182 dbSNP
rs774896964 184 dbSNP
rs750253102 185 dbSNP
rs1194176646 190 dbSNP
rs1489377782 194 dbSNP
rs1258740464 195 dbSNP
rs1214733513 197 dbSNP
rs781046651 203 dbSNP
rs1160760157 205 dbSNP
rs907162886 206 dbSNP
rs756910845 207 dbSNP
rs375286871 219 dbSNP
rs771424378 224 dbSNP
rs1316905755 226 dbSNP
rs751278995 233 dbSNP
rs1443746642 234 dbSNP
rs763655009 235 dbSNP
rs749730530 236 dbSNP
rs762590523 237 dbSNP
rs1347217326 239 dbSNP
rs1171983712 241 dbSNP
rs1440936507 246 dbSNP
rs868493901 252 dbSNP
rs1195437934 262 dbSNP
rs956426994 266 dbSNP
rs1241954406 274 dbSNP
rs1020317864 280 dbSNP
rs1447080044 283 dbSNP
rs1203278118 286 dbSNP
rs1291888047 292 dbSNP
rs1194277378 297 dbSNP
rs1252455350 303 dbSNP
rs1452808718 308 dbSNP
rs1180814711 313 dbSNP
rs1030715341 315 dbSNP
rs1469985869 319 dbSNP
rs997767840 320 dbSNP
rs1186715557 323 dbSNP
rs1486672571 326 dbSNP
rs1254619829 327 dbSNP
rs1324628855 328 dbSNP
rs1391721859 329 dbSNP
rs1210524764 333 dbSNP
rs1335409240 337 dbSNP
rs1256796872 341 dbSNP
rs1349060479 342 dbSNP
rs1212325282 344 dbSNP
rs1283026273 345 dbSNP
rs552737516 346 dbSNP
rs768266209 362 dbSNP
rs1325897305 363 dbSNP
rs1010465860 364 dbSNP
rs893423736 371 dbSNP
rs1213070793 379 dbSNP
rs1272617251 380 dbSNP
rs1467237991 382 dbSNP
rs1251449467 387 dbSNP
rs768396093 393 dbSNP
rs1418733643 398 dbSNP
rs551827803 405 dbSNP
rs1370625120 406 dbSNP
rs932205991 410 dbSNP
rs889266545 411 dbSNP
rs1298275715 413 dbSNP
rs539428988 417 dbSNP
rs571169951 420 dbSNP
rs1335933983 421 dbSNP
rs1355917559 422 dbSNP
rs944454365 427 dbSNP
rs907510916 432 dbSNP
rs1175396385 434 dbSNP
rs983090876 436 dbSNP
rs1460441849 437 dbSNP
rs1229626310 438 dbSNP
rs1371980194 439 dbSNP
rs1170608580 443 dbSNP
rs1194351876 448 dbSNP
rs1260022952 462 dbSNP
rs1486225424 468 dbSNP
rs1255968377 472 dbSNP
rs771098873 476 dbSNP
rs551250906 479 dbSNP
rs920552102 483 dbSNP
rs1170453464 485 dbSNP
rs1429928497 486 dbSNP
rs1460143405 490 dbSNP
rs1036453486 496 dbSNP
rs1254882452 502 dbSNP
rs1413900789 503 dbSNP
rs1298474572 515 dbSNP
rs1329783094 515 dbSNP
rs200443443 515 dbSNP
rs201341789 515 dbSNP
rs939323287 515 dbSNP
rs1186805791 518 dbSNP
rs1282686550 521 dbSNP
rs1486178962 521 dbSNP
rs1260100800 524 dbSNP
rs906559230 524 dbSNP
rs990605790 530 dbSNP
rs1045366280 533 dbSNP
rs779541296 534 dbSNP
rs747108675 535 dbSNP
rs758262840 547 dbSNP
rs1229618486 550 dbSNP
rs1260410310 555 dbSNP
rs1426265733 558 dbSNP
rs1194991271 561 dbSNP
rs1395262211 567 dbSNP
rs1171515957 568 dbSNP
rs1320014841 568 dbSNP
rs1346803264 572 dbSNP
rs1292851426 573 dbSNP
rs1035268655 581 dbSNP
rs1415591040 582 dbSNP
rs1359816878 585 dbSNP
rs1380551266 586 dbSNP
rs531152790 591 dbSNP
rs1371916528 592 dbSNP
rs1233928124 600 dbSNP
rs1278616843 603 dbSNP
rs1319159603 607 dbSNP
rs758117300 607 dbSNP
rs1020286866 613 dbSNP
rs1485193181 614 dbSNP
rs369681126 615 dbSNP
rs1253156748 619 dbSNP
rs976505191 623 dbSNP
rs1191409227 627 dbSNP
rs1409848489 627 dbSNP
rs1419409237 632 dbSNP
rs548750298 633 dbSNP
rs1343302416 635 dbSNP
rs1462953638 636 dbSNP
rs141869557 637 dbSNP
rs996837817 643 dbSNP
rs777799936 658 dbSNP
rs1040959555 661 dbSNP
rs559794819 662 dbSNP
rs1463116669 665 dbSNP
rs1375841449 672 dbSNP
rs1224640118 674 dbSNP
rs545834442 687 dbSNP
rs532334168 689 dbSNP
rs564059858 690 dbSNP
rs1216154886 694 dbSNP
rs953627408 708 dbSNP
rs1467668125 712 dbSNP
rs1211312995 713 dbSNP
rs1234207558 719 dbSNP
rs544065906 724 dbSNP
rs61758022 725 dbSNP
rs898027145 728 dbSNP
rs1015000778 730 dbSNP
rs920269544 731 dbSNP
rs1003651522 744 dbSNP
rs1251940817 746 dbSNP
rs990659698 748 dbSNP
rs937945012 749 dbSNP
rs906632923 754 dbSNP
rs1297946447 760 dbSNP
rs1045042651 761 dbSNP
rs1349070330 766 dbSNP
rs752930828 768 dbSNP
rs1235643786 777 dbSNP
rs948057025 778 dbSNP
rs1234153879 779 dbSNP
rs1462360529 783 dbSNP
rs1337146469 784 dbSNP
rs1168558789 785 dbSNP
rs1294903699 788 dbSNP
rs893684021 789 dbSNP
rs1236694451 793 dbSNP
rs776501561 796 dbSNP
rs1054152441 798 dbSNP
rs1188433308 801 dbSNP
rs1334929768 805 dbSNP
rs982384792 815 dbSNP
rs971490332 825 dbSNP
rs935157824 827 dbSNP
rs1161470890 830 dbSNP
rs1421808641 836 dbSNP
rs923805503 842 dbSNP
rs913361476 846 dbSNP
rs988801669 847 dbSNP
rs957322504 854 dbSNP
rs910977528 857 dbSNP
rs1446549508 860 dbSNP
rs985110664 861 dbSNP
rs1411775743 864 dbSNP
rs1339546358 866 dbSNP
rs561762466 868 dbSNP
rs1391680908 870 dbSNP
rs1033012637 877 dbSNP
rs1213596199 884 dbSNP
rs1270402832 898 dbSNP
rs542000969 899 dbSNP
rs965344483 905 dbSNP
rs1279351940 906 dbSNP
rs1195295891 909 dbSNP
rs1484639992 909 dbSNP
rs572890530 909 dbSNP
rs1475758007 911 dbSNP
rs1461644961 917 dbSNP
rs535246497 919 dbSNP
rs1009503586 921 dbSNP
rs1396308440 932 dbSNP
rs755383098 935 dbSNP
rs1436821296 942 dbSNP
rs1174651425 949 dbSNP
rs569251594 955 dbSNP
rs187698759 957 dbSNP
rs1364705855 964 dbSNP
rs1375286386 965 dbSNP
rs1184638361 967 dbSNP
rs147867799 967 dbSNP
rs866113070 982 dbSNP
rs1015075712 1003 dbSNP
rs1327563092 1005 dbSNP
rs1429358966 1018 dbSNP
rs1453062543 1023 dbSNP
rs149778469 1024 dbSNP
rs970802470 1027 dbSNP
rs1302382746 1029 dbSNP
rs994550190 1040 dbSNP
rs898811662 1044 dbSNP
rs1469871314 1054 dbSNP
rs182330982 1066 dbSNP
rs1055212852 1069 dbSNP
rs1349732585 1070 dbSNP
rs937931530 1072 dbSNP
rs1246335676 1095 dbSNP
rs1455736304 1098 dbSNP
rs1194557581 1100 dbSNP
rs1394827811 1113 dbSNP
rs878878306 1117 dbSNP
rs549105923 1123 dbSNP
rs76787426 1126 dbSNP
rs61758023 1131 dbSNP
rs945223359 1132 dbSNP
rs1302582161 1142 dbSNP
rs1441080106 1143 dbSNP
rs35657985 1144 dbSNP
rs879476087 1150 dbSNP
rs568718353 1155 dbSNP
rs1250846213 1156 dbSNP
rs943883357 1157 dbSNP
rs372338885 1160 dbSNP
rs1195273115 1163 dbSNP
rs1349864805 1174 dbSNP
rs1315832589 1181 dbSNP
rs760317965 1182 dbSNP
rs913742530 1189 dbSNP
rs753507659 1195 dbSNP
rs548545923 1205 dbSNP
rs925914588 1208 dbSNP
rs1450100724 1210 dbSNP
rs1468828134 1212 dbSNP
rs535211705 1213 dbSNP
rs1364808206 1219 dbSNP
rs1470065670 1224 dbSNP
rs964972050 1228 dbSNP
rs919606469 1233 dbSNP
rs1420687536 1240 dbSNP
rs778362524 1240 dbSNP
rs1019653452 1241 dbSNP
rs116327280 1242 dbSNP
rs1388042327 1251 dbSNP
rs1392837572 1264 dbSNP
rs1329281766 1265 dbSNP
rs950847789 1275 dbSNP
rs1334999351 1277 dbSNP
rs1407888842 1284 dbSNP
rs1295011236 1289 dbSNP
rs1026460606 1305 dbSNP
rs1194786872 1309 dbSNP
rs962257800 1324 dbSNP
rs1233917540 1325 dbSNP
rs994518959 1326 dbSNP
rs1354506169 1336 dbSNP
rs1455673026 1340 dbSNP
rs898950387 1343 dbSNP
rs552208339 1344 dbSNP
rs1251645464 1347 dbSNP
rs1482908830 1349 dbSNP
rs1192781389 1362 dbSNP
rs1447741662 1366 dbSNP
rs1284700246 1367 dbSNP
rs904533994 1374 dbSNP
rs906445316 1380 dbSNP
rs1345453984 1384 dbSNP
rs982236712 1385 dbSNP
rs17847771 1386 dbSNP
rs1419668827 1387 dbSNP
rs1267846813 1391 dbSNP
rs532384880 1393 dbSNP
rs1046708593 1395 dbSNP
rs1314507187 1395 dbSNP
rs971342095 1399 dbSNP
rs1414167629 1401 dbSNP
rs1312081686 1405 dbSNP
rs1358967828 1405 dbSNP
rs551406504 1405 dbSNP
rs77919369 1405 dbSNP
rs1429603958 1406 dbSNP
rs1326579658 1407 dbSNP
rs1319871612 1408 dbSNP
rs563375046 1410 dbSNP
rs1429733111 1411 dbSNP
rs1193309418 1412 dbSNP
rs1389111765 1414 dbSNP
rs1413380649 1416 dbSNP
rs549742799 1418 dbSNP
rs151072837 1419 dbSNP
rs530756441 1422 dbSNP
rs191278621 1426 dbSNP
rs10047149 1427 dbSNP
rs1296387121 1430 dbSNP
rs999497025 1434 dbSNP
rs1226538978 1436 dbSNP
rs945275940 1439 dbSNP
rs1306053165 1440 dbSNP
rs552046533 1441 dbSNP
rs1053629636 1448 dbSNP
rs902406460 1449 dbSNP
rs1487145483 1455 dbSNP
rs1040944481 1456 dbSNP
rs936056035 1460 dbSNP
rs1244114459 1461 dbSNP
rs1008060504 1462 dbSNP
rs1395427253 1463 dbSNP
rs1432331020 1464 dbSNP
rs187242976 1475 dbSNP
rs1365397930 1478 dbSNP
rs760126144 1479 dbSNP
rs182771889 1480 dbSNP
rs559513885 1489 dbSNP
rs889654066 1490 dbSNP
rs1328124597 1494 dbSNP
rs926053224 1499 dbSNP
rs1270274679 1500 dbSNP
rs1049470048 1504 dbSNP
rs1319250051 1512 dbSNP
rs4951374 1538 dbSNP
rs943397993 1539 dbSNP
rs749944836 1544 dbSNP
rs1279746708 1561 dbSNP
rs911900295 1562 dbSNP
rs1463196116 1566 dbSNP
rs988105740 1568 dbSNP
rs1215060024 1574 dbSNP
rs774613648 1575 dbSNP
rs1253174625 1576 dbSNP
rs946052177 1577 dbSNP
rs1036664351 1578 dbSNP
rs191108054 1579 dbSNP
rs1189238786 1580 dbSNP
rs950981690 1587 dbSNP
rs1026429623 1590 dbSNP
rs973567289 1605 dbSNP
rs982395003 1606 dbSNP
rs963097746 1607 dbSNP
rs1033883580 1620 dbSNP
rs991016723 1621 dbSNP
rs1436100538 1626 dbSNP
rs1001966151 1628 dbSNP
rs1292140584 1630 dbSNP
rs1421700844 1633 dbSNP
rs1392454347 1636 dbSNP
rs1288214713 1637 dbSNP
rs1327712776 1645 dbSNP
rs1163089221 1652 dbSNP
rs1474974308 1664 dbSNP
rs187146402 1665 dbSNP
rs1032390234 1668 dbSNP
rs1188307070 1680 dbSNP
rs1484108295 1681 dbSNP
rs769037333 1682 dbSNP
rs966714441 1704 dbSNP
rs1019485577 1706 dbSNP
rs1008582931 1707 dbSNP
rs537047590 1712 dbSNP
rs1203702419 1718 dbSNP
rs763130314 1719 dbSNP
rs1476153680 1720 dbSNP
rs4951373 1723 dbSNP
rs1028553178 1740 dbSNP
rs898215158 1741 dbSNP
rs369633402 1749 dbSNP
rs1230446752 1772 dbSNP
rs1009457142 1776 dbSNP
rs892416231 1778 dbSNP
rs1349164834 1785 dbSNP
rs1053599445 1789 dbSNP
rs761519060 1791 dbSNP
rs1417239764 1795 dbSNP
rs555205306 1799 dbSNP
rs1284244894 1809 dbSNP
rs1226140624 1817 dbSNP
rs906891721 1817 dbSNP
rs1274627325 1818 dbSNP
rs769926135 1822 dbSNP
rs1371603451 1824 dbSNP
rs949639140 1831 dbSNP
rs916856539 1837 dbSNP
rs1188621099 1840 dbSNP
rs991356163 1840 dbSNP
rs183426714 1844 dbSNP
rs1039489677 1847 dbSNP
rs773927829 1849 dbSNP
rs1443509935 1852 dbSNP
rs1402575398 1853 dbSNP
rs978184762 1862 dbSNP
rs1323903638 1868 dbSNP
rs1369142779 1871 dbSNP
rs966660699 1881 dbSNP
rs1019547389 1883 dbSNP
rs566228008 1895 dbSNP
rs987462437 1899 dbSNP
rs1445087777 1900 dbSNP
rs1271443869 1901 dbSNP
rs1365456948 1908 dbSNP
rs533147454 1911 dbSNP
rs1295087227 1916 dbSNP
rs929543673 1917 dbSNP
rs1167352376 1918 dbSNP
rs1425380542 1921 dbSNP
rs954060120 1922 dbSNP
rs919551036 1923 dbSNP
rs1028250165 1927 dbSNP
rs552335489 1928 dbSNP
rs192317615 1937 dbSNP
rs898372187 1940 dbSNP
rs1243987057 1941 dbSNP
rs1470440735 1945 dbSNP
rs1465490697 1964 dbSNP
rs1188224146 1965 dbSNP
rs1239473683 1983 dbSNP
rs1033852428 1986 dbSNP
rs1211354524 1989 dbSNP
rs980903663 2006 dbSNP
rs61758024 2007 dbSNP
rs1173532617 2010 dbSNP
rs1425011246 2011 dbSNP
rs1223273441 2012 dbSNP
rs906963860 2020 dbSNP
rs1045785811 2022 dbSNP
rs1388781171 2025 dbSNP
rs1315538362 2028 dbSNP
rs1372758807 2030 dbSNP
rs1025047536 2031 dbSNP
rs1009259101 2042 dbSNP
rs1274094453 2046 dbSNP
rs892385182 2047 dbSNP
rs1342784212 2052 dbSNP
rs1225437337 2058 dbSNP
rs1270072095 2063 dbSNP
rs1224838235 2078 dbSNP
rs1465366151 2103 dbSNP
rs564054726 2113 dbSNP
rs1246348313 2114 dbSNP
rs1000792045 2126 dbSNP
rs549800774 2130 dbSNP
rs17847775 2131 dbSNP
rs1477307964 2132 dbSNP
rs1160852607 2133 dbSNP
rs747018845 2134 dbSNP
rs943437032 2149 dbSNP
rs936836801 2155 dbSNP
rs1295542866 2156 dbSNP
rs777907370 2161 dbSNP
rs890569786 2164 dbSNP
rs1387065658 2170 dbSNP
rs1451839100 2171 dbSNP
rs925476530 2179 dbSNP
rs561836240 2180 dbSNP
rs978132351 2181 dbSNP
rs1227799548 2198 dbSNP
rs1343233875 2199 dbSNP
rs945443021 2202 dbSNP
rs1358731571 2204 dbSNP
rs1210701319 2209 dbSNP
rs1289586351 2220 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000367187.3 | 3UTR | AUUUAAAGAGAUCUGUGUACUGUUUACUUCCCACUUCCCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer 0.691 9.3e-5 0.631 4.7e-4 24 Click to see details
GSE42095 Differentiated embryonic stem cells -0.617 8.6e-4 -0.676 2.0e-4 23 Click to see details
GSE28260 Renal cortex and medulla 0.558 2.4e-2 0.516 3.6e-2 13 Click to see details
GSE32688 Pancreatic cancer -0.229 1.0e-1 -0.282 5.9e-2 32 Click to see details
GSE17498 Multiple myeloma -0.203 1.0e-1 -0.159 1.6e-1 40 Click to see details
GSE26953 Aortic valvular endothelial cells -0.264 1.1e-1 -0.055 4.0e-1 24 Click to see details
GSE27834 Pluripotent stem cells -0.273 1.5e-1 -0.238 1.9e-1 16 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.228 1.7e-1 0.567 4.6e-3 20 Click to see details
GSE14794 Lymphoblastoid cells -0.103 1.7e-1 0.009 4.7e-1 90 Click to see details
GSE17306 Multiple myeloma 0.114 2.2e-1 0.444 7.0e-4 49 Click to see details
GSE19350 CNS germ cell tumors -0.19 2.8e-1 0.035 4.6e-1 12 Click to see details
GSE21849 B cell lymphoma 0.1 3.0e-1 0.123 2.6e-1 29 Click to see details
GSE21687 Ependynoma primary tumors 0.024 4.3e-1 0.078 2.7e-1 64 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.091 4.5e-1 0.200 4.0e-1 4 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.019 4.6e-1 -0.249 1.2e-1 25 Click to see details
GSE38226 Liver fibrosis 0.018 4.7e-1 0.059 4.0e-1 21 Click to see details
GSE38226 Liver fibrosis 0.018 4.7e-1 0.059 4.0e-1 21 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
109 hsa-miR-302b-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT088427 LCLAT1 lysocardiolipin acyltransferase 1 2 4
MIRT142406 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT162006 TFRC transferrin receptor 2 2
MIRT170893 PURB purine rich element binding protein B 2 2
MIRT203348 CCNT2 cyclin T2 2 4
MIRT207353 TGOLN2 trans-golgi network protein 2 2 2
MIRT208232 CNBP CCHC-type zinc finger nucleic acid binding protein 2 4
MIRT214733 HSPA9 heat shock protein family A (Hsp70) member 9 2 2
MIRT254842 NUP50 nucleoporin 50 2 2
MIRT257285 FOXC1 forkhead box C1 2 2
MIRT338890 LLPH LLP homolog, long-term synaptic facilitation 2 2
MIRT400032 USP37 ubiquitin specific peptidase 37 2 2
MIRT404031 ATP9A ATPase phospholipid transporting 9A (putative) 2 8
MIRT405843 EIF2S1 eukaryotic translation initiation factor 2 subunit alpha 2 2
MIRT445847 FPGT fucose-1-phosphate guanylyltransferase 2 2
MIRT446350 EML6 echinoderm microtubule associated protein like 6 2 2
MIRT446649 BTBD7 BTB domain containing 7 2 2
MIRT447925 SCRN1 secernin 1 2 2
MIRT448575 PLCG1 phospholipase C gamma 1 2 2
MIRT463616 ZBTB33 zinc finger and BTB domain containing 33 2 4
MIRT465782 TMOD3 tropomodulin 3 2 2
MIRT470261 PRR14L proline rich 14 like 2 2
MIRT471090 PIK3C2B phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta 2 2
MIRT475612 HMGB1 high mobility group box 1 2 2
MIRT476824 FNDC3A fibronectin type III domain containing 3A 2 2
MIRT483107 TYRP1 tyrosinase related protein 1 2 10
MIRT500537 XPO4 exportin 4 2 2
MIRT502525 EPHA2 EPH receptor A2 2 4
MIRT510989 PER1 period circadian clock 1 2 4
MIRT512540 ZNF793 zinc finger protein 793 2 4
MIRT513868 HOXA5 homeobox A5 2 2
MIRT520756 TFDP1 transcription factor Dp-1 2 6
MIRT524304 CTC1 CST telomere replication complex component 1 2 8
MIRT526306 JAKMIP2 janus kinase and microtubule interacting protein 2 2 2
MIRT526378 LSAMP limbic system-associated membrane protein 2 2
MIRT527438 COL4A3 collagen type IV alpha 3 chain 2 2
MIRT527511 ZNF134 zinc finger protein 134 2 2
MIRT528068 HES2 hes family bHLH transcription factor 2 2 2
MIRT528367 ZMYM1 zinc finger MYM-type containing 1 2 4
MIRT531804 TFCP2L1 transcription factor CP2 like 1 2 2
MIRT532323 DUSP4 dual specificity phosphatase 4 2 2
MIRT532431 DHX33 DEAH-box helicase 33 2 2
MIRT534523 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT536660 INIP INTS3 and NABP interacting protein 2 2
MIRT538488 CLOCK clock circadian regulator 2 2
MIRT538593 CDK6 cyclin dependent kinase 6 2 2
MIRT539706 EIF3H eukaryotic translation initiation factor 3 subunit H 2 2
MIRT540306 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT546892 PURA purine rich element binding protein A 2 2
MIRT552738 YRDC yrdC N6-threonylcarbamoyltransferase domain containing 2 2
MIRT552781 YIPF6 Yip1 domain family member 6 2 2
MIRT553742 TBL1XR1 transducin beta like 1 X-linked receptor 1 2 4
MIRT553909 SUMO2 small ubiquitin-like modifier 2 2 2
MIRT554540 RRS1 ribosome biogenesis regulator homolog 2 2
MIRT555319 PPP2CB protein phosphatase 2 catalytic subunit beta 2 2
MIRT555512 PMEPA1 prostate transmembrane protein, androgen induced 1 2 2
MIRT556221 MB21D2 Mab-21 domain containing 2 2 2
MIRT556292 MAP3K5 mitogen-activated protein kinase kinase kinase 5 2 2
MIRT556606 LDOC1L retrotransposon Gag like 6 2 4
MIRT556901 ISOC1 isochorismatase domain containing 1 2 2
MIRT557675 GATA6 GATA binding protein 6 2 2
MIRT560198 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT560493 BUB3 BUB3, mitotic checkpoint protein 2 2
MIRT566069 RCC2 regulator of chromosome condensation 2 2 2
MIRT568431 GDNF glial cell derived neurotrophic factor 2 2
MIRT570703 FAM69A family with sequence similarity 69 member A 2 2
MIRT571705 RPL36A-HNRNPH2 RPL36A-HNRNPH2 readthrough 2 2
MIRT573152 ITGA9 integrin subunit alpha 9 2 2
MIRT574410 TFAP2A transcription factor AP-2 alpha 2 2
MIRT614823 PVRL4 nectin cell adhesion molecule 4 2 2
MIRT616507 COX7A2L cytochrome c oxidase subunit 7A2 like 2 2
MIRT618301 COL4A4 collagen type IV alpha 4 chain 2 2
MIRT621188 FAM153B family with sequence similarity 153 member B 2 2
MIRT621594 WT1 Wilms tumor 1 2 2
MIRT623814 GGCX gamma-glutamyl carboxylase 2 2
MIRT624407 CCDC171 coiled-coil domain containing 171 2 2
MIRT625136 CKAP2L cytoskeleton associated protein 2 like 2 2
MIRT626121 MRRF mitochondrial ribosome recycling factor 2 2
MIRT626874 AP3B1 adaptor related protein complex 3 beta 1 subunit 2 2
MIRT627874 PAN2 PAN2 poly(A) specific ribonuclease subunit 2 2
MIRT633670 FAM53B family with sequence similarity 53 member B 2 2
MIRT634285 SYAP1 synapse associated protein 1 2 2
MIRT640925 POU2F1 POU class 2 homeobox 1 2 2
MIRT642028 MYADM myeloid associated differentiation marker 2 2
MIRT643031 CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7 2 2
MIRT646122 SLC26A9 solute carrier family 26 member 9 2 2
MIRT646245 SNAP47 synaptosome associated protein 47 2 2
MIRT652457 TMEM2 transmembrane protein 2 2 2
MIRT657018 KCNK5 potassium two pore domain channel subfamily K member 5 2 2
MIRT660586 APP amyloid beta precursor protein 2 2
MIRT664316 CD209 CD209 molecule 2 2
MIRT667113 OLA1 Obg like ATPase 1 2 2
MIRT668773 DCP2 decapping mRNA 2 2 2
MIRT698430 TM4SF1 transmembrane 4 L six family member 1 2 2
MIRT700216 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT710498 CAPRIN1 cell cycle associated protein 1 2 2
MIRT711836 AMOTL2 angiomotin like 2 2 2
MIRT713226 GPR75 G protein-coupled receptor 75 2 2
MIRT714415 TBC1D16 TBC1 domain family member 16 2 2
MIRT714490 HSPA4 heat shock protein family A (Hsp70) member 4 2 2
MIRT715254 F9 coagulation factor IX 2 2
MIRT716250 PALM2 paralemmin 2 2 2
MIRT717261 BMPR2 bone morphogenetic protein receptor type 2 2 2
MIRT717730 FGF1 fibroblast growth factor 1 2 2
MIRT719262 CD44 CD44 molecule (Indian blood group) 2 2
MIRT719398 SLC15A4 solute carrier family 15 member 4 2 2
MIRT720653 TMEM218 transmembrane protein 218 2 2
MIRT720777 MSANTD3-TMEFF1 MSANTD3-TMEFF1 readthrough 2 2
MIRT722059 TMEFF1 transmembrane protein with EGF like and two follistatin like domains 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-302b Epirubicin approved 41867 Microarray osteosarcoma cells 23845851 2013 down-regualted
miR-302b Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-302b 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 up-regulated
miR-302b 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 down-regulated
miR-302b (S)-3,5-dihydroxyphenylglycine (DHPG) NULL 443586 Quantitative real-time PCR mouse brain 22309833 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-302b Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-302b-5p Paclitaxel 36314 NSC125973 approved sensitive High Laryngeal Cancer cell line (Hep2)
hsa-miR-302b-5p Celastrol 12302620 NSC70931 sensitive Low Gastric Cancer cell line (AGS)
hsa-miR-302b-5p Docetaxel 148124 NSC628503 approved sensitive Low Gastric Cancer cell line (AGS)
hsa-miR-302b-5p Doxorubicin 31703 NSC123127 approved sensitive Low Gastric Cancer cell line (AGS)
hsa-miR-302b-5p Taxol 36314 NSC125973 approved sensitive Low Gastric Cancer cell line (AGS)
hsa-miR-302b-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-302b-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-302b-5p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-302b-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-302b-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-302b-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide sensitive cell line (Bads-200)

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