miRTarBase - #MIRT471144


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pre-miRNA Information
pre-miRNA hsa-mir-4781   
Genomic Coordinates chr1: 54054079 - 54054154
Description Homo sapiens miR-4781 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4781-3p
Sequence 46| AAUGUUGGAAUCCUCGCUAGAG |67
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs968609764 2 dbSNP
rs899910686 3 dbSNP
rs74085143 4 dbSNP
rs550946107 8 dbSNP
rs747064911 10 dbSNP
rs1352517651 13 dbSNP
rs1436072914 22 dbSNP
Putative Targets

Gene Information
Gene Symbol PHF19   
Synonyms MTF2L1, PCL3, TDRD19B
Description PHD finger protein 19
Transcript NM_015651   
Other Transcripts NM_001009936   
Expression
Putative miRNA Targets on PHF19
3'UTR of PHF19
(miRNA target sites are highlighted)		 
>PHF19|NM_015651|3'UTR
   1 CTAGCCCCCGGGGGTGCCAGGGGTCCTGAAAACCAAAGGAGGAGCAGCAGAAGCCATAGGCTCCCCAGCTTTCTCCAGGC
  81 TGGGGTGGGAGAAGGAAGCAGGACAGAGCTGCAAGTGCCTGGCAGAATGCCCTGCCTGCCTGCCTGCCAGGCCAAGGCCT
 161 GCGTCTCTCTGCTGTACCAGCTCTGTTCCAGGGCCTCCTCAGGCTCGTTACCCCTGTGCCTGTGTCTCTACACACTCCAC
 241 ACCCCCTCAAACTCTGTTTATCTGTTCTCTGACCTTGTGTCCCCTGCGCTGGGACCCTTCCTCCTGAGGCCCAGGTCTTT
 321 GTCCCCAGTTGTGTGCCTTGACCTCTCTCGCCCCTTTCTGGGTGTGTTCGCACATCCTGTGTGTGCACAGCTGTCCCTCC
 401 ACTGGATCCCCTTCACACGTGACCCGTGGGGCAGCCAGTCCTCCCAGGGACTACATAACAGGCACCTTTGAGAGAGCATG
 481 GGAGAAGGTGGATAAGAGGATGCTGCTCAGTGCTTTTCTCTTCCACTTTCCTGCCACTCCCCACTACCCTCGGAGAGAGG
 561 TGGTGGGATGGGAGAGAGCCCCTGTGAAAGCCTGTGAGGATCTGAAGAGTAAAGGGCTGGGTCTGCCTCAGAAGGCACCA
 641 GCACCAGGGCCCAGGTATTAAGGCTGAGAGTGAAGGCTGCCAATGTCAGCTTTGGAGGTCCCAGAAGTCTTCTGTTCTCT
 721 GGCCTCACCCCCTCAGTCGCCATAGAGCTGGGCCTGGCCTTGCTGGAATGGAGGCATCCTTCCAAACCTGGGGGACGGGG
 801 GTGGGGGGTGGTAGTGGTGGGAGGGAAACCATGTCTTGCTAAACCTGTTTCTGGTGCCTCCCATCCCCAGACCCACCAGA
 881 CACCACACAGCAGACAATACACACCCACTCGCACAAGCTTCCATCCACATGTGTTGTACTTTCAGCTCTAGGCATGCAGA
 961 CAACCCCACACGGCCACACCACCACATGCCCAAGTGTACACACACAGAGCCACACCGTCCCTCTGGGCCTGCTGGCTCCT
1041 CCCTTGGCTTTCCCTTGGCCCACTTCCAGGGCCCAGGTGCTGCAACTAAATGTGAAAGCTCAGTGGCCGCTCCTTCTTTC
1121 AGCCCATCAACCAGCATTGGTCCCATAGGGAAGCACAGGGGACTCACCCTCTTTCATATCCCTTGCCCTGCCCTGAAATG
1201 GACAATCACTTTTTGGGATAGGTTGAAATTTTTAAAGAGCCTGCATCATTTGGTTCCCTCAAAGGGAAGCCCTTGCCAGT
1281 GGGGGTTTGAAAGAGAATTTTTGGAACCAACATTCAAATTCTGCCTCATCTGGAGGGAAACCAAAATTGGGAGGGGGAAG
1361 AGGACCCCTGATGTTTTGCTGCTTCCAGAGATATTAGAAACTGACTCACTTGATTGGAAAATGGACAAAAGTGCCTTGAC
1441 GTGGAGGGTGGGCACCAGATGGGGACCAGCCTTGCCAACTGCTGCTGTGGCCTCCAGCTTGGCTGGTTTTGCAGGCCGCC
1521 AGCAGGAAGGCGAAGGTGGTAGTACAGCAAGAGGCACTGGCGGGGCAGCAGGCCTGCAGGAGCTGTTTTTCCATTGCTAG
1601 GCCTGACCCCTCTCTACCTGTGAGCGTTCAGGGGGTCCCTGAGATAGTTTAGATGCCCCCCCATCTTAGACCTCAGCTCC
1681 CACAGTGCCTTTTAAGGGGGACCTCACCTCCTGTGCACAGCCCACCCACTTTCCTCTGCTTCCCTGGCACAGCCCAGGCA
1761 TAGACGAGCTGGCGTTGGACCCAGTTCTTCCCCCTTTTCAGCCCCACAGCTGCTGCCACAGGGGCCAACTAGGGCCAGGT
1841 GGAAGGGGAGCTGAGAAGCCAACCCCTAGCCCAGGGGTGCTGTGGGAACTGGGATCCAATTTGTAGCTTCCTGCCTGGCT
1921 TCAGAGAGCCCAGCAACCTTCTAGGCCTGCTTTCCAGACTTCTGAGATAGCCTGGGATGAGCAATCCTGTTATAGTACAT
2001 CTGGACCTTCCCTACCTGGGCTCTGGGGAGGCTGTGGGCCTGGAGAGGGAAAAGGAGGGAGGGGGTGTCTGCACCACCTG
2081 GGAAGATAGCACAAGGCCTAATGAGGTCACCCTGACTCCCCACCCCAGCATTTCATTCATACCAGATAATAGCTGCATTA
2161 CTGCCAACTGACCTTATAACCCTCTGCACCTTCAAAAAGATTCATGGTTTTTAATTGCTGCTTTTAATAACATTTGTTAA
2241 AGTTATAATTAATGTGTCTGATTTATGATTTAAAACCTCCCTTTGAACAATCAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gagaucgCUCCUAA-------GGUUGUAa 5'
                 ||| |||       ||||||| 
Target 5' tttgaaaGAGAATTTTTGGAACCAACATt 3'
 1286 - 1314 147.00 -10.10
2 
miRNA  3' gagaUCGC-UCCUAAGGUUGUAa 5'
              ||:| ||| | ||||::| 
Target 5' tgagAGTGAAGGCTGCCAATGTc 3'
 665 - 687 130.00 -11.20
3 
miRNA  3' gaGAUCGCUCCUAAGGUUGUAa 5'
            ||:| | |||  |||| || 
Target 5' atCTGGAG-GGAAACCAAAATt 3'
 1328 - 1348 127.00 -12.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN14368835 24 COSMIC
COSN31556789 45 COSMIC
COSN22220076 567 COSMIC
COSN22053786 971 COSMIC
COSN31489155 1116 COSMIC
COSN31555140 1148 COSMIC
COSN31529538 1295 COSMIC
COSN6378986 1350 COSMIC
COSN32062711 1464 COSMIC
COSN30172938 1674 COSMIC
COSN28822877 1700 COSMIC
COSN20878269 1703 COSMIC
COSN31533858 1895 COSMIC
COSN31529250 1933 COSMIC
COSN31515931 2202 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs758365979 4 dbSNP
rs750693927 5 dbSNP
rs1367274771 6 dbSNP
rs1395620273 8 dbSNP
rs765532008 9 dbSNP
rs554859029 10 dbSNP
rs767009093 10 dbSNP
rs527405490 11 dbSNP
rs754248863 15 dbSNP
rs1263324870 17 dbSNP
rs764567719 18 dbSNP
rs1327429846 23 dbSNP
rs761257275 27 dbSNP
rs775822063 29 dbSNP
rs761376089 33 dbSNP
rs765936854 33 dbSNP
rs1215379610 39 dbSNP
rs1385726868 40 dbSNP
rs1354120116 42 dbSNP
rs762430355 46 dbSNP
rs1327708784 47 dbSNP
rs772893191 48 dbSNP
rs769435251 50 dbSNP
rs766476744 56 dbSNP
rs1257353111 58 dbSNP
rs1332944518 61 dbSNP
rs1335175139 63 dbSNP
rs1329426730 69 dbSNP
rs1446061299 75 dbSNP
rs988507643 80 dbSNP
rs957226647 84 dbSNP
rs1215396394 87 dbSNP
rs535435205 94 dbSNP
rs1032802255 114 dbSNP
rs920199211 117 dbSNP
rs1187160920 121 dbSNP
rs1333876023 124 dbSNP
rs1263881002 131 dbSNP
rs992029658 132 dbSNP
rs1193013174 134 dbSNP
rs1419222942 139 dbSNP
rs1463327933 142 dbSNP
rs35429932 149 dbSNP
rs59911984 149 dbSNP
rs71506262 149 dbSNP
rs753440945 149 dbSNP
rs1001685425 153 dbSNP
rs970229891 162 dbSNP
rs1024411576 163 dbSNP
rs1014354359 166 dbSNP
rs370700058 177 dbSNP
rs967477203 196 dbSNP
rs1320914353 198 dbSNP
rs1216718306 201 dbSNP
rs1016229125 206 dbSNP
rs148268556 207 dbSNP
rs957916273 219 dbSNP
rs534781019 222 dbSNP
rs1186455893 227 dbSNP
rs1457778625 231 dbSNP
rs763098887 232 dbSNP
rs1049868850 234 dbSNP
rs1346657877 242 dbSNP
rs182759910 244 dbSNP
rs932707529 245 dbSNP
rs777457534 254 dbSNP
rs1375968066 256 dbSNP
rs900358792 259 dbSNP
rs1040249625 260 dbSNP
rs944492862 280 dbSNP
rs913156191 287 dbSNP
rs867163259 288 dbSNP
rs989131840 293 dbSNP
rs1201920810 296 dbSNP
rs898718441 301 dbSNP
rs1239473273 303 dbSNP
rs1307271326 322 dbSNP
rs1281071426 324 dbSNP
rs570641377 331 dbSNP
rs1486714809 341 dbSNP
rs1239536267 343 dbSNP
rs1056043968 345 dbSNP
rs935715098 347 dbSNP
rs925597970 349 dbSNP
rs1179390345 350 dbSNP
rs147210193 350 dbSNP
rs946083555 351 dbSNP
rs969800630 352 dbSNP
rs1023981210 355 dbSNP
rs913338580 363 dbSNP
rs1446420308 369 dbSNP
rs990111170 370 dbSNP
rs1299703436 376 dbSNP
rs1335300064 384 dbSNP
rs1416478542 393 dbSNP
rs957365262 394 dbSNP
rs1446276278 395 dbSNP
rs1304451334 402 dbSNP
rs1358233291 403 dbSNP
rs531047740 405 dbSNP
rs1278531607 406 dbSNP
rs1308642609 407 dbSNP
rs1207040048 408 dbSNP
rs1157612523 412 dbSNP
rs1231484345 418 dbSNP
rs1457623076 419 dbSNP
rs1177549248 422 dbSNP
rs1455181082 425 dbSNP
rs570211963 426 dbSNP
rs961487989 431 dbSNP
rs1424333519 437 dbSNP
rs1439832321 439 dbSNP
rs921959774 441 dbSNP
rs1381617787 450 dbSNP
rs1464924064 451 dbSNP
rs1326816415 454 dbSNP
rs1015885122 455 dbSNP
rs1006207228 463 dbSNP
rs975339463 465 dbSNP
rs1438766145 466 dbSNP
rs1274390104 475 dbSNP
rs548863178 480 dbSNP
rs964335719 482 dbSNP
rs1019415103 484 dbSNP
rs1008034515 487 dbSNP
rs888481645 500 dbSNP
rs1317616507 521 dbSNP
rs1045336341 525 dbSNP
rs949754363 529 dbSNP
rs1028721882 535 dbSNP
rs765439497 537 dbSNP
rs1273416306 538 dbSNP
rs755782634 549 dbSNP
rs901269724 550 dbSNP
rs1041115746 551 dbSNP
rs529627794 552 dbSNP
rs1421470214 556 dbSNP
rs1475460531 556 dbSNP
rs1477372415 563 dbSNP
rs1165432512 564 dbSNP
rs1396935231 565 dbSNP
rs1403768427 571 dbSNP
rs891616207 576 dbSNP
rs1237948493 584 dbSNP
rs1211982233 590 dbSNP
rs1268922180 591 dbSNP
rs1487154017 602 dbSNP
rs1340514622 616 dbSNP
rs995252221 620 dbSNP
rs898165648 629 dbSNP
rs1333173403 633 dbSNP
rs1207633995 634 dbSNP
rs1055890145 638 dbSNP
rs375272838 639 dbSNP
rs1217399987 642 dbSNP
rs1260896642 656 dbSNP
rs1053071893 662 dbSNP
rs1477482938 668 dbSNP
rs111664246 670 dbSNP
rs373466404 676 dbSNP
rs935898946 683 dbSNP
rs1471690035 686 dbSNP
rs1162828077 688 dbSNP
rs946199700 690 dbSNP
rs370137286 714 dbSNP
rs55636506 717 dbSNP
rs1304341529 724 dbSNP
rs1360419715 726 dbSNP
rs1415881228 733 dbSNP
rs913284794 738 dbSNP
rs925870796 739 dbSNP
rs936095120 750 dbSNP
rs921943023 752 dbSNP
rs762235870 756 dbSNP
rs1351000244 758 dbSNP
rs1224946717 759 dbSNP
rs979752956 762 dbSNP
rs1283201888 763 dbSNP
rs975162386 773 dbSNP
rs1226628396 774 dbSNP
rs559315528 779 dbSNP
rs942609287 783 dbSNP
rs1285231953 785 dbSNP
rs1233633416 789 dbSNP
rs113098701 790 dbSNP
rs532221934 796 dbSNP
rs1297267481 797 dbSNP
rs1419890810 802 dbSNP
rs1435435667 802 dbSNP
rs565018778 803 dbSNP
rs973773417 808 dbSNP
rs1330028490 809 dbSNP
rs1337924321 809 dbSNP
rs1448482893 809 dbSNP
rs962804391 815 dbSNP
rs555616620 821 dbSNP
rs1162131016 823 dbSNP
rs1033989473 832 dbSNP
rs1234455483 839 dbSNP
rs1404178376 844 dbSNP
rs1414465481 851 dbSNP
rs1342835045 856 dbSNP
rs776907027 860 dbSNP
rs1273383287 861 dbSNP
rs543603161 881 dbSNP
rs1183515070 886 dbSNP
rs917001467 889 dbSNP
rs1476757901 895 dbSNP
rs1262165298 897 dbSNP
rs1376410003 901 dbSNP
rs992537362 902 dbSNP
rs961598502 911 dbSNP
rs576190256 921 dbSNP
rs907412772 929 dbSNP
rs1024985466 931 dbSNP
rs1328853897 931 dbSNP
rs1440964977 933 dbSNP
rs908688170 939 dbSNP
rs1328867776 943 dbSNP
rs566498828 952 dbSNP
rs1219468255 953 dbSNP
rs1232388027 954 dbSNP
rs554539351 962 dbSNP
rs1321135176 963 dbSNP
rs1251818921 965 dbSNP
rs984411923 972 dbSNP
rs1319723091 974 dbSNP
rs953094678 977 dbSNP
rs1028544725 984 dbSNP
rs542924201 985 dbSNP
rs965332601 991 dbSNP
rs73541858 996 dbSNP
rs1009641865 997 dbSNP
rs1375344043 1002 dbSNP
rs551561945 1002 dbSNP
rs114043822 1007 dbSNP
rs1399068202 1010 dbSNP
rs1000003379 1015 dbSNP
rs146959890 1016 dbSNP
rs564701463 1017 dbSNP
rs558632978 1030 dbSNP
rs1463980165 1034 dbSNP
rs1216548840 1043 dbSNP
rs1277283472 1053 dbSNP
rs1422772138 1057 dbSNP
rs1247179777 1060 dbSNP
rs1335271476 1060 dbSNP
rs1263916630 1062 dbSNP
rs1488191847 1076 dbSNP
rs948426187 1077 dbSNP
rs377458716 1080 dbSNP
rs1193596587 1085 dbSNP
rs916908581 1088 dbSNP
rs918404334 1102 dbSNP
rs1056840827 1108 dbSNP
rs865997513 1109 dbSNP
rs1264138466 1110 dbSNP
rs1366424230 1113 dbSNP
rs1456943119 1116 dbSNP
rs1288997957 1119 dbSNP
rs537200239 1120 dbSNP
rs1189678158 1122 dbSNP
rs1398027455 1124 dbSNP
rs1488234440 1134 dbSNP
rs1355792325 1144 dbSNP
rs1229880198 1145 dbSNP
rs908264025 1149 dbSNP
rs984709735 1161 dbSNP
rs962465948 1172 dbSNP
rs1456852479 1176 dbSNP
rs1351633522 1179 dbSNP
rs952877936 1181 dbSNP
rs1257907764 1183 dbSNP
rs1258841241 1185 dbSNP
rs979758606 1209 dbSNP
rs1180521958 1210 dbSNP
rs1253620243 1223 dbSNP
rs971461548 1233 dbSNP
rs1159426553 1235 dbSNP
rs1381558351 1250 dbSNP
rs914842 1251 dbSNP
rs548565266 1252 dbSNP
rs1298825121 1253 dbSNP
rs892067742 1270 dbSNP
rs186308283 1275 dbSNP
rs1273076028 1277 dbSNP
rs1374681119 1279 dbSNP
rs1239585744 1282 dbSNP
rs1281633921 1285 dbSNP
rs1314519269 1288 dbSNP
rs1208674713 1293 dbSNP
rs566271570 1296 dbSNP
rs1255733968 1297 dbSNP
rs550011068 1301 dbSNP
rs975660048 1308 dbSNP
rs181927946 1310 dbSNP
rs1367754509 1315 dbSNP
rs1437273475 1341 dbSNP
rs190521985 1349 dbSNP
rs1327358771 1358 dbSNP
rs1425754994 1362 dbSNP
rs1416047757 1366 dbSNP
rs1443886955 1368 dbSNP
rs965399845 1369 dbSNP
rs1358293762 1372 dbSNP
rs1462316750 1378 dbSNP
rs1399460928 1393 dbSNP
rs1033155659 1394 dbSNP
rs1019607354 1399 dbSNP
rs564927935 1412 dbSNP
rs149269527 1424 dbSNP
rs186153155 1425 dbSNP
rs1463383141 1431 dbSNP
rs1375714338 1433 dbSNP
rs1301207587 1434 dbSNP
rs1009546507 1440 dbSNP
rs957018008 1441 dbSNP
rs944850126 1445 dbSNP
rs1197646277 1449 dbSNP
rs1032392437 1459 dbSNP
rs890435974 1474 dbSNP
rs1426091281 1475 dbSNP
rs1000437976 1478 dbSNP
rs904351657 1479 dbSNP
rs771720594 1481 dbSNP
rs1478022537 1492 dbSNP
rs1172620222 1513 dbSNP
rs1397877933 1514 dbSNP
rs531371107 1517 dbSNP
rs918520228 1523 dbSNP
rs1044321869 1531 dbSNP
rs181237760 1532 dbSNP
rs927182661 1533 dbSNP
rs980255630 1535 dbSNP
rs1220825004 1536 dbSNP
rs971194079 1538 dbSNP
rs1317720627 1541 dbSNP
rs916891172 1544 dbSNP
rs1290166175 1551 dbSNP
rs1209795368 1554 dbSNP
rs895512325 1560 dbSNP
rs202217214 1561 dbSNP
rs770527772 1562 dbSNP
rs956237504 1562 dbSNP
rs1488549378 1572 dbSNP
rs1033270389 1577 dbSNP
rs533070511 1581 dbSNP
rs1048105407 1582 dbSNP
rs542488639 1583 dbSNP
rs1416317996 1588 dbSNP
rs572304031 1607 dbSNP
rs41302653 1625 dbSNP
rs138415806 1626 dbSNP
rs776127784 1631 dbSNP
rs1402351707 1634 dbSNP
rs150082542 1638 dbSNP
rs1376311066 1639 dbSNP
rs1340226781 1657 dbSNP
rs993460436 1662 dbSNP
rs397825635 1663 dbSNP
rs570909410 1663 dbSNP
rs5900463 1663 dbSNP
rs1226281552 1671 dbSNP
rs897043365 1689 dbSNP
rs1038243124 1698 dbSNP
rs1218628627 1701 dbSNP
rs1261018808 1702 dbSNP
rs1487839153 1706 dbSNP
rs1188049596 1707 dbSNP
rs1239410761 1709 dbSNP
rs941325585 1713 dbSNP
rs77484121 1714 dbSNP
rs1380920847 1717 dbSNP
rs537565815 1718 dbSNP
rs576494636 1723 dbSNP
rs555121968 1734 dbSNP
rs1360519312 1735 dbSNP
rs1415370819 1738 dbSNP
rs1336610927 1759 dbSNP
rs116609171 1765 dbSNP
rs1313943345 1766 dbSNP
rs1376977029 1771 dbSNP
rs1241777551 1773 dbSNP
rs548113059 1774 dbSNP
rs1200990627 1777 dbSNP
rs1280422899 1779 dbSNP
rs1440485522 1783 dbSNP
rs968553796 1792 dbSNP
rs1239076256 1800 dbSNP
rs1441616198 1804 dbSNP
rs955685497 1806 dbSNP
rs1380200997 1818 dbSNP
rs1022737277 1819 dbSNP
rs1012682051 1833 dbSNP
rs1483749808 1836 dbSNP
rs369976338 1837 dbSNP
rs140639231 1842 dbSNP
rs1004290353 1846 dbSNP
rs1352388037 1848 dbSNP
rs1286078389 1850 dbSNP
rs1018158980 1858 dbSNP
rs1009084060 1870 dbSNP
rs1240499960 1873 dbSNP
rs954750909 1875 dbSNP
rs1334689900 1876 dbSNP
rs1233796617 1877 dbSNP
rs1026362719 1879 dbSNP
rs571278760 1880 dbSNP
rs1311852385 1886 dbSNP
rs1459296152 1893 dbSNP
rs1048652472 1894 dbSNP
rs1396452598 1901 dbSNP
rs1237574998 1937 dbSNP
rs189681550 1948 dbSNP
rs1201631124 1954 dbSNP
rs769883390 1955 dbSNP
rs899559282 1959 dbSNP
rs1171896832 1963 dbSNP
rs1466829874 1964 dbSNP
rs1039908261 1967 dbSNP
rs899169025 1970 dbSNP
rs1386900738 1971 dbSNP
rs531417238 1974 dbSNP
rs1360079482 1976 dbSNP
rs1187908164 1981 dbSNP
rs1159253150 1982 dbSNP
rs1222648628 1986 dbSNP
rs1837 1993 dbSNP
rs1319747510 2011 dbSNP
rs1216968903 2015 dbSNP
rs1005868450 2016 dbSNP
rs1488846672 2022 dbSNP
rs1211757815 2025 dbSNP
rs549153736 2031 dbSNP
rs1367249040 2035 dbSNP
rs1451492399 2036 dbSNP
rs905799742 2042 dbSNP
rs1265707336 2048 dbSNP
rs912820086 2052 dbSNP
rs1475776387 2059 dbSNP
rs1168073578 2067 dbSNP
rs1372211252 2072 dbSNP
rs1457940910 2078 dbSNP
rs1164545641 2089 dbSNP
rs1260007234 2094 dbSNP
rs1387974491 2096 dbSNP
rs988407240 2100 dbSNP
rs935362439 2101 dbSNP
rs1404215080 2127 dbSNP
rs1298747626 2135 dbSNP
rs1397984977 2143 dbSNP
rs1295088103 2146 dbSNP
rs1322608937 2148 dbSNP
rs1247293641 2161 dbSNP
rs576025850 2176 dbSNP
rs1191123126 2177 dbSNP
rs776916280 2187 dbSNP
rs559966191 2190 dbSNP
rs1044584553 2227 dbSNP
rs925293253 2236 dbSNP
rs1217913785 2247 dbSNP
rs1266043726 2254 dbSNP
rs1487507468 2254 dbSNP
rs377734737 2254 dbSNP
rs1186335558 2260 dbSNP
rs949872655 2267 dbSNP
rs542813455 2271 dbSNP
rs1189226908 2277 dbSNP
rs969465156 2278 dbSNP
rs1052854593 2280 dbSNP
rs1023648836 2281 dbSNP
rs991291379 2282 dbSNP
rs959828118 2294 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gagaucgcuccuaaGGUUGUAa 5'
                        ||||||| 
Target 5' ------------aaCCAACAUu 3'
 		1 - 10
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000373896.3 | 3UTR | AACCAACAUUCAAAUUCUGCCUCAUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
204 hsa-miR-4781-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT071728 CCNK cyclin K 2 2
MIRT184858 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT205881 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT218699 ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 2 2
MIRT223783 OXR1 oxidation resistance 1 2 2
MIRT242435 GAN gigaxonin 2 2
MIRT306825 NCBP2 nuclear cap binding protein subunit 2 2 2
MIRT334170 CCND1 cyclin D1 2 6
MIRT339617 TMPO thymopoietin 2 2
MIRT400371 C2ORF68 chromosome 2 open reading frame 68 2 2
MIRT445533 KIF1B kinesin family member 1B 2 4
MIRT450273 F2RL2 coagulation factor II thrombin receptor like 2 2 2
MIRT450701 RORA RAR related orphan receptor A 2 2
MIRT451160 C19orf53 chromosome 19 open reading frame 53 2 2
MIRT453775 NUCB1 nucleobindin 1 2 10
MIRT453884 IFRD1 interferon related developmental regulator 1 2 12
MIRT454238 OSBPL10 oxysterol binding protein like 10 2 9
MIRT458661 PAGR1 PAXIP1 associated glutamate rich protein 1 2 12
MIRT466948 STAU1 staufen double-stranded RNA binding protein 1 2 2
MIRT470278 PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 2 2
MIRT471144 PHF19 PHD finger protein 19 2 2
MIRT471873 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT476739 FOXN2 forkhead box N2 2 2
MIRT480453 C16orf72 chromosome 16 open reading frame 72 2 6
MIRT482107 AKT3 AKT serine/threonine kinase 3 2 4
MIRT483374 CYP4A22 cytochrome P450 family 4 subfamily A member 22 2 2
MIRT484063 CYP4A11 cytochrome P450 family 4 subfamily A member 11 2 2
MIRT496329 SH3BGRL SH3 domain binding glutamate rich protein like 2 2
MIRT498659 AP3B2 adaptor related protein complex 3 beta 2 subunit 2 4
MIRT498711 PGAM5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase 2 10
MIRT499322 ZNF485 zinc finger protein 485 2 6
MIRT499711 NFATC2IP nuclear factor of activated T-cells 2 interacting protein 2 10
MIRT499767 CIRH1A UTP4, small subunit processome component 2 6
MIRT499912 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 8
MIRT504946 ZSWIM6 zinc finger SWIM-type containing 6 2 4
MIRT505377 TMEM154 transmembrane protein 154 2 4
MIRT508778 GSG1 germ cell associated 1 2 2
MIRT509793 CHAF1B chromatin assembly factor 1 subunit B 2 4
MIRT512421 LAYN layilin 2 4
MIRT513321 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT513592 DCTN6 dynactin subunit 6 2 2
MIRT514785 RBM4B RNA binding motif protein 4B 2 2
MIRT514859 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 2
MIRT515122 LMOD3 leiomodin 3 2 2
MIRT515271 CSNK1E casein kinase 1 epsilon 2 2
MIRT515594 FBXL13 F-box and leucine rich repeat protein 13 2 2
MIRT515880 PLXDC2 plexin domain containing 2 2 2
MIRT515908 AGTPBP1 ATP/GTP binding protein 1 2 2
MIRT515960 C9orf156 tRNA methyltransferase O 2 2
MIRT517210 OTUD6A OTU deubiquitinase 6A 2 2
MIRT517330 ZNF347 zinc finger protein 347 2 2
MIRT517480 PEX26 peroxisomal biogenesis factor 26 2 2
MIRT517594 ZNF579 zinc finger protein 579 2 4
MIRT517676 TRIM72 tripartite motif containing 72 2 2
MIRT518215 TRMT10B tRNA methyltransferase 10B 2 2
MIRT518583 ATP8B1 ATPase phospholipid transporting 8B1 2 2
MIRT518777 ZFP14 ZFP14 zinc finger protein 2 2
MIRT519094 SLC4A1 solute carrier family 4 member 1 (Diego blood group) 2 4
MIRT519112 ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 2 2
MIRT519400 DNASE2 deoxyribonuclease 2, lysosomal 2 4
MIRT519446 GLA galactosidase alpha 2 2
MIRT519476 SPTLC2 serine palmitoyltransferase long chain base subunit 2 2 2
MIRT519711 ZNF584 zinc finger protein 584 2 4
MIRT521409 RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 2 2
MIRT521522 QSOX1 quiescin sulfhydryl oxidase 1 2 2
MIRT522652 MANEAL mannosidase endo-alpha like 2 2
MIRT523505 GMPS guanine monophosphate synthase 2 4
MIRT523795 FAM63B MINDY lysine 48 deubiquitinase 2 2 2
MIRT524062 DNAJC8 DnaJ heat shock protein family (Hsp40) member C8 2 2
MIRT524136 DMXL1 Dmx like 1 2 2
MIRT524192 DENND4C DENN domain containing 4C 2 4
MIRT525925 KIAA0391 KIAA0391 2 2
MIRT528021 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT528685 CEP57L1 centrosomal protein 57 like 1 2 2
MIRT528769 CD1D CD1d molecule 2 2
MIRT529373 YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta 2 4
MIRT529469 ZNF546 zinc finger protein 546 2 2
MIRT529641 ZNF621 zinc finger protein 621 2 2
MIRT530681 CHRNB1 cholinergic receptor nicotinic beta 1 subunit 2 4
MIRT530752 GPR82 G protein-coupled receptor 82 2 2
MIRT531628 TM4SF5 transmembrane 4 L six family member 5 2 4
MIRT531649 C19orf52 translocase of inner mitochondrial membrane 29 2 4
MIRT532179 SEC14L5 SEC14 like lipid binding 5 2 4
MIRT532219 CCDC117 coiled-coil domain containing 117 2 2
MIRT534238 SLC25A16 solute carrier family 25 member 16 2 4
MIRT539952 SLC30A5 solute carrier family 30 member 5 2 2
MIRT540179 MB21D1 Mab-21 domain containing 1 2 2
MIRT540466 ZNF71 zinc finger protein 71 2 2
MIRT540560 PPIC peptidylprolyl isomerase C 2 2
MIRT543265 ZNF662 zinc finger protein 662 2 2
MIRT543596 KIAA1549 KIAA1549 2 2
MIRT543971 RNF20 ring finger protein 20 2 2
MIRT544053 C9orf64 chromosome 9 open reading frame 64 2 2
MIRT544605 DCAF5 DDB1 and CUL4 associated factor 5 2 2
MIRT544679 AP1S1 adaptor related protein complex 1 sigma 1 subunit 2 2
MIRT547627 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT550668 TRAF1 TNF receptor associated factor 1 2 2
MIRT551533 EMB embigin 2 2
MIRT552443 ZNF449 zinc finger protein 449 2 2
MIRT559265 BAG4 BCL2 associated athanogene 4 2 4
MIRT562479 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT564211 SDE2 SDE2 telomere maintenance homolog 2 2
MIRT565973 RPP14 ribonuclease P/MRP subunit p14 2 2
MIRT570524 SHH sonic hedgehog 2 2
MIRT575307 Osbpl10 oxysterol binding protein-like 10 2 6
MIRT618212 C22orf39 chromosome 22 open reading frame 39 2 2
MIRT620115 HARBI1 harbinger transposase derived 1 2 2
MIRT624062 EIF4E eukaryotic translation initiation factor 4E 2 2
MIRT626083 CWF19L1 CWF19 like 1, cell cycle control (S. pombe) 2 2
MIRT629868 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT630750 COG6 component of oligomeric golgi complex 6 2 2
MIRT631002 ZNF573 zinc finger protein 573 2 2
MIRT631100 UQCRB ubiquinol-cytochrome c reductase binding protein 2 2
MIRT631290 SGSM1 small G protein signaling modulator 1 2 2
MIRT631337 CD300E CD300e molecule 2 2
MIRT631532 MYO6 myosin VI 2 2
MIRT631644 WDR91 WD repeat domain 91 2 4
MIRT632788 LZIC leucine zipper and CTNNBIP1 domain containing 2 2
MIRT633282 FGFR1OP2 FGFR1 oncogene partner 2 2 2
MIRT633593 ABRACL ABRA C-terminal like 2 2
MIRT634074 PLIN3 perilipin 3 2 2
MIRT634163 YME1L1 YME1 like 1 ATPase 2 2
MIRT634257 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT634679 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT638384 RABL3 RAB, member of RAS oncogene family like 3 2 2
MIRT638687 GCLM glutamate-cysteine ligase modifier subunit 2 2
MIRT640311 PRR13 proline rich 13 2 2
MIRT641132 NPHP3 nephrocystin 3 2 2
MIRT642315 FPR1 formyl peptide receptor 1 2 2
MIRT643703 KIAA0586 KIAA0586 2 2
MIRT644322 NFKBID NFKB inhibitor delta 2 2
MIRT645741 POLR3A RNA polymerase III subunit A 2 2
MIRT646975 CYP2W1 cytochrome P450 family 2 subfamily W member 1 2 2
MIRT648064 TRMT10C tRNA methyltransferase 10C, mitochondrial RNase P subunit 2 2
MIRT648536 CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 2 2
MIRT649294 NEK8 NIMA related kinase 8 2 2
MIRT650014 KLB klotho beta 2 2
MIRT650551 YIPF4 Yip1 domain family member 4 2 2
MIRT651796 UTP6 UTP6, small subunit processome component 2 2
MIRT652647 TIMM10 translocase of inner mitochondrial membrane 10 2 2
MIRT653548 SLC38A7 solute carrier family 38 member 7 2 2
MIRT653895 SGK3 serum/glucocorticoid regulated kinase family member 3 2 2
MIRT655470 PAK3 p21 (RAC1) activated kinase 3 2 2
MIRT657764 GMEB1 glucocorticoid modulatory element binding protein 1 2 2
MIRT659118 DENND6A DENN domain containing 6A 2 2
MIRT659377 CREG2 cellular repressor of E1A stimulated genes 2 2 2
MIRT659836 CARHSP1 calcium regulated heat stable protein 1 2 2
MIRT659954 C8orf44-SGK3 C8orf44-SGK3 readthrough 2 2
MIRT660258 BLOC1S6 biogenesis of lysosomal organelles complex 1 subunit 6 2 2
MIRT663268 ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 2 2
MIRT663766 ZNF285 zinc finger protein 285 2 2
MIRT666198 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 2
MIRT669763 ZNF101 zinc finger protein 101 2 4
MIRT669933 LRPAP1 LDL receptor related protein associated protein 1 2 2
MIRT670007 GPR156 G protein-coupled receptor 156 2 4
MIRT670465 RSBN1L round spermatid basic protein 1 like 2 2
MIRT670868 IFNAR1 interferon alpha and beta receptor subunit 1 2 4
MIRT671313 RABGAP1L RAB GTPase activating protein 1 like 2 2
MIRT671959 SPPL3 signal peptide peptidase like 3 2 2
MIRT672281 SHE Src homology 2 domain containing E 2 2
MIRT673654 CYCS cytochrome c, somatic 2 2
MIRT674063 ATXN3 ataxin 3 2 2
MIRT674423 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT674438 MIOX myo-inositol oxygenase 2 4
MIRT674483 BCL2L15 BCL2 like 15 2 2
MIRT675478 NUBPL nucleotide binding protein like 2 2
MIRT675648 TTPAL alpha tocopherol transfer protein like 2 2
MIRT675981 FAM126B family with sequence similarity 126 member B 2 2
MIRT676251 PARP2 poly(ADP-ribose) polymerase 2 2 2
MIRT677652 HAUS2 HAUS augmin like complex subunit 2 2 2
MIRT682718 KIAA1456 KIAA1456 2 2
MIRT687545 MOB1B MOB kinase activator 1B 2 2
MIRT689620 AKAP6 A-kinase anchoring protein 6 2 2
MIRT690035 CCDC90B coiled-coil domain containing 90B 2 2
MIRT691449 CXorf36 chromosome X open reading frame 36 2 2
MIRT691549 FLYWCH2 FLYWCH family member 2 2 2
MIRT691737 LARS leucyl-tRNA synthetase 2 2
MIRT692638 SUSD1 sushi domain containing 1 2 2
MIRT693866 IYD iodotyrosine deiodinase 2 2
MIRT693979 ZNF70 zinc finger protein 70 2 2
MIRT694150 CYP27C1 cytochrome P450 family 27 subfamily C member 1 2 2
MIRT695492 TRAT1 T-cell receptor associated transmembrane adaptor 1 2 2
MIRT695547 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2 2
MIRT696023 TYRO3 TYRO3 protein tyrosine kinase 2 2
MIRT696402 CORO7 coronin 7 2 2
MIRT703028 HEATR5A HEAT repeat containing 5A 2 2
MIRT703559 FKBP14 FK506 binding protein 14 2 2
MIRT705036 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT705120 C4orf29 abhydrolase domain containing 18 2 2
MIRT706611 CYB5B cytochrome b5 type B 2 2
MIRT706635 PNPT1 polyribonucleotide nucleotidyltransferase 1 2 2
MIRT706730 RFK riboflavin kinase 2 2
MIRT706868 MAFF MAF bZIP transcription factor F 2 2
MIRT707020 RRP36 ribosomal RNA processing 36 2 2
MIRT707036 ACTR5 ARP5 actin related protein 5 homolog 2 2
MIRT707125 ZNF154 zinc finger protein 154 2 2
MIRT707390 SLC35F6 solute carrier family 35 member F6 2 2
MIRT708664 LYRM7 LYR motif containing 7 2 2
MIRT713010 BBX BBX, HMG-box containing 2 2
MIRT717314 TRAF3IP1 TRAF3 interacting protein 1 2 2
MIRT721912 C6orf201 chromosome 6 open reading frame 201 2 2
MIRT723050 YTHDC1 YTH domain containing 1 2 2
MIRT725038 NDUFAF7 NADH:ubiquinone oxidoreductase complex assembly factor 7 2 2
MIRT755316 SMAD5 SMAD family member 5 4 1
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4781-3p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4781-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-4781-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4781-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)

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