miRTarBase - #MIRT471369


—
pre-miRNA Information
pre-miRNA hsa-mir-3618   
Genomic Coordinates chr22: 20085746 - 20085833
Description Homo sapiens miR-3618 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3618
Sequence 52| UGUCUACAUUAAUGAAAAGAGC |73
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 11 22 + 20085807 27587585 MiREDiBase
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30730356 3 COSMIC
COSN30178222 4 COSMIC
COSN26973254 21 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs12159555 4 dbSNP
rs761877586 8 dbSNP
Putative Targets

Gene Information
Gene Symbol PDZD8   
Synonyms PDZK8
Description PDZ domain containing 8
Transcript NM_173791   
Expression
Putative miRNA Targets on PDZD8
3'UTR of PDZD8
(miRNA target sites are highlighted)		 
>PDZD8|NM_173791|3'UTR
   1 CAGACAGGTCTATTTAAACTTTCAAATGAACAGGGTAAAGTTGCATCTAAAGTACCACAGATACAACCATGTTTAAATCC
  81 TCGTATGCACTCTGGCCTGCTTCTCCAGTTACTTGCTTGTGTAAGAACAAAAATGAGAAAGGTTGTTTTCCAGTAAAAAC
 161 ATGACCAGCTTACTAATTGGTTGTTTTGGATTGCATTTATAGCTATGCTTTTTTGGGTTTATACTGGGAATTTATTTTTA
 241 CTAAATTATTTAACTTTTCTAATTATGTAATTATGTAAGCTAGCTTTTCATGTTTATGTATGTATGGTGTCCCCTTGTGT
 321 TATTTTTCTTCCTCTTGGTTTTTGAATTAGTGTTAAATAGAATACTGTCTAGATTCTTAAAATATTTTCATTTCCATCAT
 401 GGTTATAACAAATTTGCTGCATGCCCAAACTGACAACAGCAATCACTGAGGGAACAGGTTTTGAATCTTTCTTTTGTGTT
 481 ATGAAGTTTATCGTCTCTACTTGCTTGAGATTTTTGTTATTTTGGGGGTTTGGGGGTGCTTTTTGTTTTGTTTTTGCCAA
 561 ATGTAACATGAAAGCAGATGCTGCAGCTTTAGTCTGTTATGCTGATTTAGTAAAAAAAAATTTTTTACATATATTGCTTG
 641 CTTTCGATGCTTCTGTGAAATTTTTTTCTAAAGCTTTTGTGCAGCTGTATGGTAAAAATATGGTGATTAATTTGAAGAGC
 721 TTACATTGAAAGACAATGTAATAGGAAATAAATGTAGATTGCAGTTGGTCAAGAATTTTGTAGAGAGGATAACAAGACTT
 801 AATTACTGAAAAACAGTAACATAGCATTTTGAAATATAATCTTTTAAAATATTGATGCTTTCCTTTTAAATGGAAATTTA
 881 AATTTTATAATTAAAAGTTTAAACATTTATGATAATTTTCCTCATCAGTTCTCCCATAGGAAATAAAGCATGTGAAAGGG
 961 TATTTAAAGTTTTGGAGGACTCTTTTTAAAATGACTGTGTTGATAACTAGTTTGGGCTGGTTTTGTTTTAGAAAAAACAT
1041 TTTCATGTAGGAGTATTCTGTGAAGGAAAGGAATCATGCAAAATATACTTTTTGCTTTGGCGTCTTACAGTTGTAAAGGA
1121 ATGGTGATCATTCTGAATACTTCTGTAGTGAGTATTCATTAAGAAAAGAATGACAAAAATAGTATTCATACATAGGAATT
1201 GGGACCAGTTCTCTGAAAATGAAGATATACTCACACTGGGTCCATTTTACGGGTCCCAGTAACATTTGACTGAGGGAAAA
1281 CAAGTAAGCTCGACTGTTGTTGGGGTACCTTAATGGTTTCGGTCTGTTATATACCTATAAAATAGACAAGTATATGTTTG
1361 TCCCTTTGTAGGTAACTGCTATGATGATTGCTATATAGTGAAACTGACATGAGTTTAAAACTAGATGGAGCAGCTTTTAT
1441 TGCTGGCAGGAAAAAGCATGGTGTAATATTAAGGACTGGGGCCCAGGTCTAGACTCCAGGACTCCATAAAAGAGTTTAAG
1521 TTCAAGCCCTTCCATTAATGAACTGTGTAAGCATAGGCAGTTACAAAAGGACCCATCTCTAAAATGGGAATAATAATACT
1601 TTACCTCCCTCACAGTATTGTTGTGAGGGAAACAATAGCATAACTGCAAAAGTGCTTTGAACAGTAAAAAGATATACAAG
1681 TAAAAGGCATTATTTATATGAGTAAGAAAGACATTTTTGAGGGGAGAAAAGTTATTCCACTTTAAAAATCAATAGCCAAG
1761 TCTCATGCCTTTTGTTACTTTAGTAAGCGAAAATTTCAGGTACTAAATACCTTTCTTAGCCAAGTTTATAACAAAAACAT
1841 CTCAGTATACTTCATTACTTATTTAAGCGTGATGTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGA
1921 CAGAGTCTCGCTGTCTCCCAGGCTGGAGTGCAGTGGCATGATCTCGGCTCACTGCAAGCTCCGCCTCCCAGGTTCACGCC
2001 ATTCTCCTGCCTCAGCCTCCGGAGTAGCTGGGAGTACAGGCGCGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTC
2081 ACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGG
2161 CGTGAGCCACCACGCCCGGCCACGTGATCTTATTTTAAAAGAACACTGCTATAGAAGAATTTACACACCAAATTCCCTGA
2241 AAGCTAAAGTATTGTTCCATAACTTACACTTGAGGCAATCTGCTCAGTGTGTAACCACTTTATAAAAAATAACTTACCAT
2321 TGATAACCTGGAAGGTGGACTACTTGTAAGTAGCTGGTGTTTATTGATTAAACCATGGAAGTTTTCATGATACCCAAGCA
2401 TGTTGCTGAAACTGATGCATTTGAAAGAGCTGTTGAAATAATGCAAAACTTTGGTTTTATAAGAATCTACTCATGTTTTA
2481 AAAGTATTTAACTCTGTAGACCACAATTATAGAAAGCTCAGTAATGCTGCTAATGACATTTGTAAACTATATCTGTAATG
2561 TAGTGCAATATTTTTATATTTCACTGGGAGAGGCAGTAGAGACATCATAGTTGTACTTTAGTGCAAGTGGGGGAACACTC
2641 CAAATAGCCTAGAGTATAGTAAGGTACAAAGCTTCAATGAAAAAAGCTGTATTATATTACATTACTGATGTAATCTTGCT
2721 GCCATGCTATGTATCAATAGCTAAAAAATAATAATAAAGACTACCACAGAAAACAAGAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cgAGAAAAGU------AAUU---ACAUCUGu 5'
            | |||| |      ||||   ||||||| 
Target 5' caTGTTTTAAAAGTATTTAACTCTGTAGACc 3'
 2472 - 2502 154.00 -7.90
2 
miRNA  3' cgagaaaagUAAUUACAUCUGu 5'
                   || ||||||||: 
Target 5' taataggaaATAAATGTAGATt 3'
 739 - 760 141.00 -8.40
3 
miRNA  3' cgagaaaAGUAAUU---ACAUCUgu 5'
                 |||  ||   ||||||  
Target 5' cagttggTCAAGAATTTTGTAGAga 3'
 762 - 786 127.00 -5.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
1175418 5770 ClinVar
COSN26557529 19 COSMIC
COSN31488712 42 COSMIC
COSN30493745 53 COSMIC
COSN30497705 83 COSMIC
COSN30522829 83 COSMIC
COSN31604408 92 COSMIC
COSN30448984 105 COSMIC
COSN31602355 125 COSMIC
COSN509994 133 COSMIC
COSN30622190 163 COSMIC
COSN15444765 206 COSMIC
COSN27710831 287 COSMIC
COSN24014832 1150 COSMIC
COSN6058144 1307 COSMIC
COSN29861856 1492 COSMIC
COSN26839928 1747 COSMIC
COSN1472933 1952 COSMIC
COSN21016539 1957 COSMIC
COSN6058143 2832 COSMIC
COSN15367684 4102 COSMIC
COSN1472931 4264 COSMIC
COSN1113056 4640 COSMIC
COSN8149963 5370 COSMIC
COSN5247571 5533 COSMIC
COSN31547984 5766 COSMIC
COSN23013156 5770 COSMIC
COSN28885566 5875 COSMIC
COSN28189246 5952 COSMIC
COSN30530608 5973 COSMIC
COSN30107480 5983 COSMIC
COSN30115445 5984 COSMIC
COSN30526275 5993 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1385406729 2 dbSNP
rs778852716 5 dbSNP
rs754733812 6 dbSNP
rs375815140 8 dbSNP
rs963869245 9 dbSNP
rs185939030 12 dbSNP
rs115171479 13 dbSNP
rs363293 18 dbSNP
rs764244203 21 dbSNP
rs763144424 22 dbSNP
rs753192002 24 dbSNP
rs765856053 37 dbSNP
rs760151413 41 dbSNP
rs363292 44 dbSNP
rs760224078 45 dbSNP
rs1307986340 46 dbSNP
rs879321720 46 dbSNP
rs772874832 49 dbSNP
rs363291 54 dbSNP
rs537877604 57 dbSNP
rs900195514 60 dbSNP
rs1021954166 64 dbSNP
rs1250185116 65 dbSNP
rs1479388568 67 dbSNP
rs1011532960 72 dbSNP
rs1408279749 74 dbSNP
rs1242354071 79 dbSNP
rs1000989144 82 dbSNP
rs575465203 83 dbSNP
rs891710683 85 dbSNP
rs181610355 94 dbSNP
rs535600747 104 dbSNP
rs1368561183 116 dbSNP
rs1444480580 120 dbSNP
rs938507981 126 dbSNP
rs1298806590 135 dbSNP
rs363290 137 dbSNP
rs757202812 141 dbSNP
rs1271603960 142 dbSNP
rs543520969 144 dbSNP
rs751612323 150 dbSNP
rs1306148700 154 dbSNP
rs1046540880 160 dbSNP
rs1228073719 164 dbSNP
rs568047034 188 dbSNP
rs948034335 194 dbSNP
rs1221447243 205 dbSNP
rs1206075666 207 dbSNP
rs189260196 209 dbSNP
rs1272210442 214 dbSNP
rs1232946638 221 dbSNP
rs916618249 227 dbSNP
rs1191388843 228 dbSNP
rs1047280932 244 dbSNP
rs1254450245 249 dbSNP
rs539526795 258 dbSNP
rs570483780 273 dbSNP
rs942254845 275 dbSNP
rs1417367655 293 dbSNP
rs1411587006 294 dbSNP
rs908135184 302 dbSNP
rs1349348934 303 dbSNP
rs1434333017 304 dbSNP
rs1319777427 309 dbSNP
rs763662840 317 dbSNP
rs1371913116 331 dbSNP
rs1434840636 340 dbSNP
rs1038378242 355 dbSNP
rs762598324 361 dbSNP
rs937422942 366 dbSNP
rs775166080 368 dbSNP
rs12337 371 dbSNP
rs1030026509 378 dbSNP
rs184821321 399 dbSNP
rs970570847 402 dbSNP
rs964731135 424 dbSNP
rs536226790 425 dbSNP
rs917773053 426 dbSNP
rs1274680249 428 dbSNP
rs1169346879 447 dbSNP
rs1468633063 451 dbSNP
rs1474123026 459 dbSNP
rs988025896 471 dbSNP
rs1240113727 476 dbSNP
rs569493632 476 dbSNP
rs192760675 478 dbSNP
rs1412925870 481 dbSNP
rs1000574547 482 dbSNP
rs773570825 486 dbSNP
rs1395564137 490 dbSNP
rs1456906531 492 dbSNP
rs964125958 493 dbSNP
rs1018047423 495 dbSNP
rs1221286073 508 dbSNP
rs1007951240 517 dbSNP
rs1431886804 520 dbSNP
rs1284133161 523 dbSNP
rs529589441 525 dbSNP
rs1046506487 528 dbSNP
rs948200015 530 dbSNP
rs1335122121 536 dbSNP
rs560301822 548 dbSNP
rs1341764181 555 dbSNP
rs1448553034 562 dbSNP
rs1037680693 563 dbSNP
rs942046139 567 dbSNP
rs1025776872 576 dbSNP
rs1047997628 583 dbSNP
rs1190230152 589 dbSNP
rs994342093 591 dbSNP
rs1291784609 594 dbSNP
rs1435480780 599 dbSNP
rs933482965 600 dbSNP
rs866671779 601 dbSNP
rs898793379 608 dbSNP
rs1342662579 610 dbSNP
rs1401667059 611 dbSNP
rs540456711 620 dbSNP
rs1374247214 621 dbSNP
rs937388571 621 dbSNP
rs964459410 621 dbSNP
rs534549887 627 dbSNP
rs1407805487 629 dbSNP
rs1389181507 632 dbSNP
rs1237655243 633 dbSNP
rs1277412403 635 dbSNP
rs1173639607 636 dbSNP
rs905922828 645 dbSNP
rs1455244054 646 dbSNP
rs1393789687 648 dbSNP
rs1045791750 650 dbSNP
rs1212902577 653 dbSNP
rs533441720 654 dbSNP
rs1481148986 660 dbSNP
rs1258092625 664 dbSNP
rs74159163 679 dbSNP
rs989807750 682 dbSNP
rs987975094 685 dbSNP
rs1202894972 698 dbSNP
rs1365827457 724 dbSNP
rs935233215 726 dbSNP
rs1172401625 743 dbSNP
rs552842467 743 dbSNP
rs955922042 744 dbSNP
rs41284390 748 dbSNP
rs979494001 764 dbSNP
rs1345890796 767 dbSNP
rs1390325237 768 dbSNP
rs963724246 780 dbSNP
rs1018371303 787 dbSNP
rs575555360 788 dbSNP
rs971214399 792 dbSNP
rs1373996418 797 dbSNP
rs955128974 815 dbSNP
rs1236142085 819 dbSNP
rs1280975782 821 dbSNP
rs1341359124 824 dbSNP
rs1407769248 832 dbSNP
rs363288 834 dbSNP
rs1313171394 841 dbSNP
rs1438660199 841 dbSNP
rs1436011756 842 dbSNP
rs1251328828 844 dbSNP
rs1455858495 852 dbSNP
rs895209220 853 dbSNP
rs1373131050 863 dbSNP
rs994332208 870 dbSNP
rs1165687635 888 dbSNP
rs1460911374 888 dbSNP
rs363240 889 dbSNP
rs363239 894 dbSNP
rs1324811955 905 dbSNP
rs886478150 912 dbSNP
rs1442910783 914 dbSNP
rs1017211297 915 dbSNP
rs1325826530 923 dbSNP
rs1002210655 936 dbSNP
rs1472508271 937 dbSNP
rs1258474419 938 dbSNP
rs933535240 948 dbSNP
rs905833610 951 dbSNP
rs1046151694 958 dbSNP
rs372269786 967 dbSNP
rs1039173657 969 dbSNP
rs1484831307 988 dbSNP
rs1255438419 993 dbSNP
rs1171835970 1007 dbSNP
rs1194727001 1013 dbSNP
rs943550127 1018 dbSNP
rs573210037 1032 dbSNP
rs914308651 1038 dbSNP
rs553181718 1041 dbSNP
rs1226330157 1047 dbSNP
rs1391922700 1060 dbSNP
rs1349695357 1085 dbSNP
rs1293491152 1086 dbSNP
rs149251332 1093 dbSNP
rs1376550923 1096 dbSNP
rs768701394 1101 dbSNP
rs924310495 1102 dbSNP
rs1297641799 1108 dbSNP
rs372308314 1109 dbSNP
rs981105494 1126 dbSNP
rs1347460972 1128 dbSNP
rs1291505497 1142 dbSNP
rs935179469 1143 dbSNP
rs925127395 1152 dbSNP
rs971268511 1171 dbSNP
rs979345391 1172 dbSNP
rs1260310816 1181 dbSNP
rs1157666453 1189 dbSNP
rs1457024886 1190 dbSNP
rs1207208579 1195 dbSNP
rs1263121820 1198 dbSNP
rs942621027 1208 dbSNP
rs962894053 1214 dbSNP
rs138363683 1227 dbSNP
rs1475874636 1228 dbSNP
rs1165235837 1232 dbSNP
rs1419083669 1242 dbSNP
rs910850678 1249 dbSNP
rs1016344141 1250 dbSNP
rs1474315839 1251 dbSNP
rs986470849 1254 dbSNP
rs1311188479 1255 dbSNP
rs1357465913 1261 dbSNP
rs1233929280 1274 dbSNP
rs1006757678 1276 dbSNP
rs955119524 1292 dbSNP
rs1047687563 1294 dbSNP
rs1485659593 1296 dbSNP
rs1486921430 1299 dbSNP
rs1209383304 1300 dbSNP
rs1478008793 1316 dbSNP
rs532998820 1320 dbSNP
rs749326247 1321 dbSNP
rs902079132 1330 dbSNP
rs184407652 1337 dbSNP
rs758559519 1346 dbSNP
rs1039715756 1347 dbSNP
rs972858229 1352 dbSNP
rs962885755 1362 dbSNP
rs1017531850 1363 dbSNP
rs879390736 1379 dbSNP
rs1273532495 1381 dbSNP
rs1364134984 1383 dbSNP
rs73394912 1385 dbSNP
rs1319485684 1395 dbSNP
rs1377123286 1405 dbSNP
rs1311657453 1417 dbSNP
rs1297678142 1424 dbSNP
rs1371507982 1430 dbSNP
rs1393343095 1431 dbSNP
rs970716163 1434 dbSNP
rs1347650943 1435 dbSNP
rs1232467281 1456 dbSNP
rs150169743 1460 dbSNP
rs934356612 1461 dbSNP
rs1210289543 1478 dbSNP
rs1231785890 1480 dbSNP
rs529524858 1482 dbSNP
rs566848363 1483 dbSNP
rs1014298438 1485 dbSNP
rs1238362535 1498 dbSNP
rs1319093999 1501 dbSNP
rs1453578328 1513 dbSNP
rs1191449791 1518 dbSNP
rs1396887194 1523 dbSNP
rs891872618 1526 dbSNP
rs1053217060 1536 dbSNP
rs1414942841 1550 dbSNP
rs1434963502 1551 dbSNP
rs1395872700 1573 dbSNP
rs924363093 1576 dbSNP
rs1000703035 1579 dbSNP
rs903652813 1581 dbSNP
rs1456771002 1596 dbSNP
rs1368098901 1598 dbSNP
rs1171450941 1599 dbSNP
rs949724722 1605 dbSNP
rs1370456091 1614 dbSNP
rs1043954087 1616 dbSNP
rs1439233515 1617 dbSNP
rs1306077164 1620 dbSNP
rs1372412400 1621 dbSNP
rs942630690 1622 dbSNP
rs780001925 1625 dbSNP
rs546761552 1627 dbSNP
rs991851341 1629 dbSNP
rs1050707816 1662 dbSNP
rs1205919598 1674 dbSNP
rs1258316713 1675 dbSNP
rs1467752424 1679 dbSNP
rs1191561285 1686 dbSNP
rs933683198 1688 dbSNP
rs1259691802 1698 dbSNP
rs1478207823 1698 dbSNP
rs918273255 1703 dbSNP
rs41284388 1705 dbSNP
rs1430397433 1707 dbSNP
rs192328145 1708 dbSNP
rs1253556186 1718 dbSNP
rs370475347 1722 dbSNP
rs950775382 1728 dbSNP
rs1395698671 1729 dbSNP
rs1268935823 1731 dbSNP
rs1430404112 1731 dbSNP
rs910009944 1737 dbSNP
rs115454918 1757 dbSNP
rs970328263 1762 dbSNP
rs1227761798 1766 dbSNP
rs1024590480 1773 dbSNP
rs1308926653 1774 dbSNP
rs901880887 1778 dbSNP
rs1014244528 1779 dbSNP
rs1008262071 1780 dbSNP
rs1451972118 1783 dbSNP
rs1214739908 1788 dbSNP
rs955997300 1789 dbSNP
rs1054996696 1796 dbSNP
rs1372356838 1806 dbSNP
rs1031685752 1810 dbSNP
rs1417223065 1811 dbSNP
rs1385428609 1815 dbSNP
rs902918575 1818 dbSNP
rs1000246357 1820 dbSNP
rs865854182 1821 dbSNP
rs1390512257 1828 dbSNP
rs1045537630 1838 dbSNP
rs530490308 1840 dbSNP
rs1400501454 1841 dbSNP
rs1316661088 1845 dbSNP
rs562050840 1855 dbSNP
rs1007166770 1857 dbSNP
rs1463674039 1858 dbSNP
rs1388568829 1861 dbSNP
rs1354310398 1868 dbSNP
rs1294762344 1869 dbSNP
rs1167969107 1874 dbSNP
rs991173950 1876 dbSNP
rs1223070685 1881 dbSNP
rs1281843175 1883 dbSNP
rs1395603033 1884 dbSNP
rs1200974583 1885 dbSNP
rs1487724411 1887 dbSNP
rs1449623244 1888 dbSNP
rs1211565838 1889 dbSNP
rs1266363185 1890 dbSNP
rs1196183892 1891 dbSNP
rs1204620185 1891 dbSNP
rs1306342393 1892 dbSNP
rs1481371427 1893 dbSNP
rs1448711987 1895 dbSNP
rs1272121116 1900 dbSNP
rs1203793093 1901 dbSNP
rs1217274436 1902 dbSNP
rs1348034315 1904 dbSNP
rs1306225051 1906 dbSNP
rs1231656960 1911 dbSNP
rs1157244957 1917 dbSNP
rs1173567787 1917 dbSNP
rs1190082619 1917 dbSNP
rs1213192176 1917 dbSNP
rs1240513802 1917 dbSNP
rs1256669781 1917 dbSNP
rs1277356967 1917 dbSNP
rs1279399980 1917 dbSNP
rs1279534452 1917 dbSNP
rs1335619133 1917 dbSNP
rs1340737057 1917 dbSNP
rs1345621208 1917 dbSNP
rs1355624632 1917 dbSNP
rs1374116251 1917 dbSNP
rs1410653633 1917 dbSNP
rs1412449338 1917 dbSNP
rs1420652562 1917 dbSNP
rs1440995498 1917 dbSNP
rs1469812116 1917 dbSNP
rs1484732257 1917 dbSNP
rs371488653 1917 dbSNP
rs57494461 1917 dbSNP
rs763936369 1917 dbSNP
rs79601715 1917 dbSNP
rs1331053527 1918 dbSNP
rs2532811 1922 dbSNP
rs1393509442 1924 dbSNP
rs1368949075 1929 dbSNP
rs1440713239 1930 dbSNP
rs1193388475 1932 dbSNP
rs1307725771 1937 dbSNP
rs889683746 1942 dbSNP
rs1435395123 1943 dbSNP
rs1437092664 1943 dbSNP
rs941241528 1945 dbSNP
rs1170927335 1946 dbSNP
rs1050946981 1947 dbSNP
rs1476973427 1952 dbSNP
rs1377002978 1959 dbSNP
rs1182251116 1965 dbSNP
rs1326450060 1966 dbSNP
rs1473483551 1969 dbSNP
rs542272592 1982 dbSNP
rs765264656 1983 dbSNP
rs909814449 1984 dbSNP
rs1256476096 1989 dbSNP
rs11197941 1991 dbSNP
rs1485810052 1997 dbSNP
rs1194091578 1999 dbSNP
rs1275458094 2000 dbSNP
rs1037105687 2001 dbSNP
rs1198242024 2004 dbSNP
rs1251495847 2015 dbSNP
rs1455817050 2015 dbSNP
rs183435566 2020 dbSNP
rs909656740 2021 dbSNP
rs1261896295 2025 dbSNP
rs980282069 2031 dbSNP
rs1165636867 2032 dbSNP
rs948923009 2034 dbSNP
rs966069718 2041 dbSNP
rs553320564 2042 dbSNP
rs917440465 2043 dbSNP
rs867518603 2044 dbSNP
rs1324747649 2048 dbSNP
rs1392062213 2059 dbSNP
rs1388230016 2064 dbSNP
rs1320437357 2065 dbSNP
rs1349076592 2072 dbSNP
rs993046750 2073 dbSNP
rs1225426865 2084 dbSNP
rs1280141296 2085 dbSNP
rs192044495 2090 dbSNP
rs1017982106 2094 dbSNP
rs956279988 2095 dbSNP
rs1232919863 2103 dbSNP
rs1415582615 2104 dbSNP
rs1489672007 2115 dbSNP
rs1031674325 2117 dbSNP
rs979205749 2118 dbSNP
rs1261709437 2120 dbSNP
rs548253669 2121 dbSNP
rs1414043449 2122 dbSNP
rs1190446097 2126 dbSNP
rs893349515 2128 dbSNP
rs576967361 2133 dbSNP
rs1163767279 2134 dbSNP
rs1415137368 2143 dbSNP
rs1459302229 2148 dbSNP
rs188524233 2152 dbSNP
rs1007663905 2156 dbSNP
rs536738372 2157 dbSNP
rs112751809 2160 dbSNP
rs2803809 2161 dbSNP
rs1158173368 2162 dbSNP
rs1232677626 2168 dbSNP
rs1029456431 2170 dbSNP
rs998016519 2172 dbSNP
rs554118851 2174 dbSNP
rs1013976193 2176 dbSNP
rs1036690049 2177 dbSNP
rs941051679 2178 dbSNP
rs534336877 2184 dbSNP
rs1044513845 2188 dbSNP
rs746133593 2193 dbSNP
rs11197940 2201 dbSNP
rs948460618 2209 dbSNP
rs909772639 2211 dbSNP
rs1234300258 2222 dbSNP
rs1046994986 2223 dbSNP
rs1425158999 2228 dbSNP
rs929803744 2236 dbSNP
rs566786945 2246 dbSNP
rs1160384448 2258 dbSNP
rs1414303999 2267 dbSNP
rs993036872 2267 dbSNP
rs1320400969 2278 dbSNP
rs1396803883 2286 dbSNP
rs1306498209 2292 dbSNP
rs934893344 2295 dbSNP
rs1437122790 2296 dbSNP
rs1242696983 2301 dbSNP
rs1287436258 2304 dbSNP
rs1386374136 2305 dbSNP
rs1158055193 2312 dbSNP
rs976555724 2313 dbSNP
rs1209585031 2316 dbSNP
rs1415496485 2317 dbSNP
rs1161151243 2329 dbSNP
rs546894680 2333 dbSNP
rs1483920033 2335 dbSNP
rs11197939 2336 dbSNP
rs1182115243 2346 dbSNP
rs1249295296 2349 dbSNP
rs1437603687 2356 dbSNP
rs966489023 2365 dbSNP
rs924888742 2372 dbSNP
rs1380913131 2375 dbSNP
rs1433992130 2378 dbSNP
rs1373113199 2379 dbSNP
rs1171903066 2383 dbSNP
rs1360988709 2386 dbSNP
rs1189965875 2387 dbSNP
rs183192351 2395 dbSNP
rs986512818 2402 dbSNP
rs1247956289 2409 dbSNP
rs969102304 2412 dbSNP
rs1017619240 2417 dbSNP
rs957423435 2423 dbSNP
rs1033257013 2426 dbSNP
rs1356296518 2436 dbSNP
rs986585249 2440 dbSNP
rs954792940 2452 dbSNP
rs1453734885 2453 dbSNP
rs548459011 2457 dbSNP
rs1313443208 2460 dbSNP
rs1210134395 2464 dbSNP
rs1250466494 2470 dbSNP
rs1287954434 2475 dbSNP
rs1200349800 2480 dbSNP
rs1238537876 2484 dbSNP
rs1453518030 2492 dbSNP
rs1189431474 2506 dbSNP
rs999150038 2510 dbSNP
rs1227912958 2517 dbSNP
rs1169820488 2519 dbSNP
rs1398426802 2532 dbSNP
rs757037945 2548 dbSNP
rs1340345588 2565 dbSNP
rs570950122 2568 dbSNP
rs967628814 2577 dbSNP
rs1024444979 2587 dbSNP
rs551192739 2596 dbSNP
rs138125617 2616 dbSNP
rs998006682 2621 dbSNP
rs894193519 2627 dbSNP
rs1226278277 2628 dbSNP
rs1005616479 2629 dbSNP
rs562185451 2631 dbSNP
rs363287 2636 dbSNP
rs1046962699 2643 dbSNP
rs528506151 2652 dbSNP
rs1467881270 2657 dbSNP
rs1219095895 2659 dbSNP
rs1015949745 2662 dbSNP
rs1319877003 2662 dbSNP
rs2848 2667 dbSNP
rs929856155 2669 dbSNP
rs1351449989 2670 dbSNP
rs922528440 2678 dbSNP
rs1005485374 2689 dbSNP
rs1421609740 2692 dbSNP
rs559638208 2701 dbSNP
rs1404343246 2706 dbSNP
rs185956906 2712 dbSNP
rs942565210 2716 dbSNP
rs1447195607 2747 dbSNP
rs1044070478 2751 dbSNP
rs1430615425 2758 dbSNP
rs1287581350 2759 dbSNP
rs1390076449 2769 dbSNP
rs1401223785 2778 dbSNP
rs1278510877 2780 dbSNP
rs910607713 2799 dbSNP
rs948449279 2810 dbSNP
rs1291733819 2816 dbSNP
rs895603569 2827 dbSNP
rs1215026462 2840 dbSNP
rs182335132 2859 dbSNP
rs758443725 2860 dbSNP
rs1479308380 2869 dbSNP
rs934841121 2870 dbSNP
rs766130636 2872 dbSNP
rs1221309318 2877 dbSNP
rs577108881 2882 dbSNP
rs924824137 2888 dbSNP
rs1438538126 2889 dbSNP
rs1415006241 2892 dbSNP
rs1277117030 2915 dbSNP
rs1157388414 2919 dbSNP
rs977430565 2919 dbSNP
rs967594518 2923 dbSNP
rs1043674157 2924 dbSNP
rs947673729 2935 dbSNP
rs1203098182 2938 dbSNP
rs910501702 2946 dbSNP
rs1296747049 2947 dbSNP
rs752192543 2955 dbSNP
rs1285554725 2957 dbSNP
rs376394069 2971 dbSNP
rs954783623 2986 dbSNP
rs1034505362 2987 dbSNP
rs1005339418 3000 dbSNP
rs1355759427 3002 dbSNP
rs1217484440 3021 dbSNP
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rs1279670742 3027 dbSNP
rs543628297 3031 dbSNP
rs145498532 3036 dbSNP
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rs1238198686 3043 dbSNP
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rs1440824090 3057 dbSNP
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rs534277901 3075 dbSNP
rs1400913421 3079 dbSNP
rs1354749519 3086 dbSNP
rs1335797978 3089 dbSNP
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rs1015439925 3101 dbSNP
rs1379082051 3108 dbSNP
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rs762653788 3118 dbSNP
rs1302536058 3124 dbSNP
rs901072682 3133 dbSNP
rs1202189575 3137 dbSNP
rs1427226267 3164 dbSNP
rs1005842397 3183 dbSNP
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rs1023047177 3200 dbSNP
rs1012617878 3201 dbSNP
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rs35547062 3208 dbSNP
rs1193567605 3210 dbSNP
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rs1376373079 3215 dbSNP
rs1476790936 3216 dbSNP
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rs1464755684 3230 dbSNP
rs1402229512 3231 dbSNP
rs529277139 3231 dbSNP
rs889667920 3235 dbSNP
rs539731614 3237 dbSNP
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rs1317324181 3261 dbSNP
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rs1260168921 3270 dbSNP
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rs1470751607 3281 dbSNP
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rs1200428818 3302 dbSNP
rs1254222687 3312 dbSNP
rs1246804023 3317 dbSNP
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rs1425256069 3323 dbSNP
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rs1162402744 3346 dbSNP
rs1388553914 3348 dbSNP
rs926040613 3349 dbSNP
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rs1318874199 3372 dbSNP
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rs1199476184 4744 dbSNP
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rs1199201970 4859 dbSNP
rs1251379175 4862 dbSNP
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rs1335791081 4873 dbSNP
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rs958187084 5955 dbSNP
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rs778764888 5966 dbSNP
rs1389844235 5967 dbSNP
rs768463448 5968 dbSNP
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rs760222264 5974 dbSNP
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rs771962858 5990 dbSNP
rs772059897 5990 dbSNP
rs1158795818 5994 dbSNP
rs1281173313 5994 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cgagaAAAGUAAUUACAUCUGu 5'
               ||| | |  ||||||| 
Target 5' ---uaUUUAACU-CUGUAGACc 3'
 		1 - 18
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000334464.5 | 3UTR | UAUUUAACUCUGUAGACCACAAUUAUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
29 hsa-miR-3618 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT378435 SOX4 SRY-box 4 2 2
MIRT459627 GABARAP GABA type A receptor-associated protein 2 2
MIRT471295 PGAM4 phosphoglycerate mutase family member 4 2 2
MIRT471369 PDZD8 PDZ domain containing 8 2 2
MIRT504886 MRPL51 mitochondrial ribosomal protein L51 2 2
MIRT505938 RBM33 RNA binding motif protein 33 2 8
MIRT525461 TMPRSS12 transmembrane protease, serine 12 2 2
MIRT526767 ZNF527 zinc finger protein 527 2 2
MIRT526990 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT528669 PDE4DIP phosphodiesterase 4D interacting protein 2 6
MIRT538462 CNBP CCHC-type zinc finger nucleic acid binding protein 2 2
MIRT542899 HSBP1 heat shock factor binding protein 1 2 2
MIRT550274 AHI1 Abelson helper integration site 1 2 2
MIRT551674 BBS5 Bardet-Biedl syndrome 5 2 2
MIRT551689 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT551755 TRIM42 tripartite motif containing 42 2 2
MIRT555769 PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 2 2
MIRT556241 MARCH9 membrane associated ring-CH-type finger 9 2 2
MIRT556926 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 4
MIRT562638 ARID1A AT-rich interaction domain 1A 2 2
MIRT571348 RPL37 ribosomal protein L37 2 2
MIRT612818 KLHL3 kelch like family member 3 2 2
MIRT619329 TIPRL TOR signaling pathway regulator 2 4
MIRT653927 SERPINC1 serpin family C member 1 2 2
MIRT659150 DDHD1 DDHD domain containing 1 2 2
MIRT688334 FAM126B family with sequence similarity 126 member B 2 2
MIRT694760 FZD2 frizzled class receptor 2 2 2
MIRT700477 PUM1 pumilio RNA binding family member 1 2 2
MIRT702375 KLF10 Kruppel like factor 10 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3618 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-3618 Paclitaxel 36314 NSC125973 approved sensitive cell line (W1)
hsa-mir-3618 Cisplatin 5460033 NSC119875 approved sensitive cell line (W1)
hsa-mir-3618 Methotrexate 126941 NSC740 approved sensitive cell line (W1)
hsa-mir-3618 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-3618 Tamoxifen 2733525 NSC180973 approved resistant cell line (LCC2)
hsa-miR-3618 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-3618 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3618 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide/Methotrexate/Gemcitabine resistant cell line (Bats-72)
hsa-miR-3618 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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