miRTarBase - #MIRT471690


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pre-miRNA Information
pre-miRNA hsa-mir-642b   
Genomic Coordinates chr19: 45674932 - 45675008
Description Homo sapiens miR-642b stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-642b-3p
Sequence 47| AGACACAUUUGGAGAGGGACCC |68
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN24410683 6 COSMIC
COSN8407659 14 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs778534861 2 dbSNP
rs111664333 4 dbSNP
rs998995912 5 dbSNP
rs1206620651 6 dbSNP
rs1317907103 7 dbSNP
rs374751972 13 dbSNP
rs78902025 15 dbSNP
rs775648115 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol OXR1   
Synonyms Nbla00307, TLDC3
Description oxidation resistance 1
Transcript NM_018002   
Other Transcripts NM_181354   
Expression
Putative miRNA Targets on OXR1
3'UTR of OXR1
(miRNA target sites are highlighted)		 
>OXR1|NM_018002|3'UTR
   1 ATAAAATGCTCTCTGTCTTAGCAGGAGAATGGCCCAAACCTGACATGGACAAGCATTGTTTGGAAAGTTCAAGAAGCAAT
  81 ACAGTGTAACATGTCACTTGTGCTTTAAAATTAGTCTGTATCACCATTTATTACAGTTATAATTTTGGAGTTTATTTTTC
 161 AAATCATGTTCTTGTCCCAGAGTTCTTTAGGTTAACACTAGGGACTGCGTCCATGTACTAGTATAACAGCTTGGGTTTGT
 241 TAGAATTTGGGCAACATTTTGATTATAATGACAACTTCATTTTCACATGTTACTCAGTTCCCTAATAGGATGGTGCTCTT
 321 TTGTTGAACCTGTATTGATTTTTTTTTTTTTAACTATATTGATTCGTTTACTAGAACAGTCTAATTGGGGCATTGAGGAA
 401 ATGAAGACTGGATACTTCTGTATCTGTGAAGTTGGCACAGGTAACATTTGGACATGTTCATCTTATTCTTAGGAAGGAAA
 481 AAATCACTTGCCAAAATAATACATACTTCATAGACCACTGAGTTCTAGTTTTTATTCACACTACAACATTCTCTTTAACG
 561 ATGTTGCAGGTATTCTCAATTTCCTTTTAAGAAAAATGAAATGTGAGGAGAATTCTGGTTGTAATAGATGACAGTACATA
 641 TGATCTGCAGGTTTGGGCATATGCTTTCATCATTAAATTATCTGATAAAGTTACAAGTCACAAAGGAGAATGAGAACTTA
 721 ATGATTCTATTGGATTTAATATATTAGCAAGAAAACATACTATTTACATATGTGTAGCTTAGTAAGGCATTAACATAAGT
 801 ACAAAAACTATGAAACAGATGCATATTTCCTCAACATACTGTGTCAGGTATACTGTTTTATAATTTGGTTGTTTTAGCCT
 881 TATTGCACACCAACTCCCAAAATATAGGTTACTCTTGTTCAAAAGGAAAAAAAAAATTGTGATTTTCTTTGAGTGGTATA
 961 TGTTATTAATTACCATTAGCATTTGCTCTTATAAAGGGCAATGATTATAGTAGACAATATTGTAACTCAGTAGACTTGTT
1041 GAATATGCAAACTTACTGTCAAGTGACCTCAAAAAAAAAATGAAAAGATAGAATACACTAGTAGTTCTTATCCTCTTTTG
1121 TAGGAAACCAATAATAGCCATTGTGGCAATAATTCATCAGTTGATTTTAAAGCTTCATGTTATGCAAAAAAGAATCCTGC
1201 TGTTATACATGTGACAGTGACTTTGTGCTGAAATTTCAGCTATTCCAGATAAACATTGTATATCTTGTAAATTAATGTTT
1281 AAAGGTGTAGTTTTGTTCTTACAGAAAGTGTTGATTGCCAGGTTGCTTATAGCACTTTAAGTTATTCTAAAAATGAAATT
1361 ATAAGCCAAATATTTGGCTTAAGTAGATTTAGTTGTATAGCACTTACATATTTAGTTCTTTTGAAAGTTTAGATAATTAT
1441 TTAAAGAAAGCATAATGCTAATGGAAAAGAAAATCTGATGTTCTATTATAATATGCTATTGCTGAATATGAATAGAAATA
1521 CAGGGCATCATTTCCTTGTCTCATTATAAGTTAGTAACAATATATAGATTAAATGTTTACAATATAGGGAATTGTAAATA
1601 AATATATCAGTTTTTTTCCCCTTCGGTCTTCCACAGCAGTATTATTGTCTTTGTGGAGTTGACTAATGATAATTTAAAAA
1681 TCCTGTAATGGATTTCTACTAAAATAAGGTCATAGTGGCATATACCAAATAAAATCAAATACAGAAATACAAAAAAAAAA
1761 AAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cccaGGGAGAGGUUUACACAga 5'
              |: |:| || ||||||  
Target 5' cataCTATTTACATATGTGTag 3'
 756 - 777 138.00 -7.70
2 
miRNA  3' cccAGGGAGAGGU-UUACACAGa 5'
             |:||||  || | |||||| 
Target 5' tatTTCCTCAACATACTGTGTCa 3'
 824 - 846 135.00 -15.00
3 
miRNA  3' cccAGG--GA-GAGGUUUACACAGa 5'
             |||  || :| :| ||||| | 
Target 5' gaaTCCTGCTGTTATACATGTGACa 3'
 1192 - 1216 121.00 -8.22
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30172016 4 COSMIC
COSN30172008 14 COSMIC
COSN23156052 22 COSMIC
COSN30147957 28 COSMIC
COSN30110635 34 COSMIC
COSN30468103 36 COSMIC
COSN30488107 71 COSMIC
COSN30529826 80 COSMIC
COSN30518379 121 COSMIC
COSN31549536 172 COSMIC
COSN32057068 203 COSMIC
COSN30507384 204 COSMIC
COSN31546673 209 COSMIC
COSN23376525 223 COSMIC
COSN21537645 255 COSMIC
COSN29936421 297 COSMIC
COSN27220833 352 COSMIC
COSN29079135 352 COSMIC
COSN24921142 511 COSMIC
COSN25030889 775 COSMIC
COSN31531941 922 COSMIC
COSN29560974 937 COSMIC
COSN31541163 1054 COSMIC
COSN23324861 1081 COSMIC
COSN30538231 1113 COSMIC
COSN20810616 1147 COSMIC
COSN31549521 1165 COSMIC
COSN24302671 1263 COSMIC
COSN20105787 1288 COSMIC
COSN31550542 1359 COSMIC
COSN2249803 1383 COSMIC
COSN8518090 1401 COSMIC
COSN31585261 1476 COSMIC
COSN31549108 1490 COSMIC
COSN21869040 1539 COSMIC
COSN31595321 1622 COSMIC
COSN24522175 1636 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1209903809 2 dbSNP
rs769763595 4 dbSNP
rs1416101683 11 dbSNP
rs1425515711 16 dbSNP
rs774345666 17 dbSNP
rs368939354 19 dbSNP
rs1448939089 20 dbSNP
rs749354163 26 dbSNP
rs1195464195 28 dbSNP
rs905800844 32 dbSNP
rs768878559 33 dbSNP
rs1302668784 34 dbSNP
rs1475131386 35 dbSNP
rs1403321117 43 dbSNP
rs1238109246 45 dbSNP
rs1477187377 47 dbSNP
rs1398357189 49 dbSNP
rs529017883 52 dbSNP
rs984515064 54 dbSNP
rs1313465622 56 dbSNP
rs1206340111 66 dbSNP
rs994668785 71 dbSNP
rs553846730 77 dbSNP
rs190102270 84 dbSNP
rs910332914 91 dbSNP
rs943032487 92 dbSNP
rs1027911791 101 dbSNP
rs1284246721 107 dbSNP
rs886151496 114 dbSNP
rs1450192073 115 dbSNP
rs1005060389 119 dbSNP
rs1018586216 131 dbSNP
rs976193511 141 dbSNP
rs923541135 149 dbSNP
rs965671424 151 dbSNP
rs934875927 158 dbSNP
rs1165054353 163 dbSNP
rs1471822761 166 dbSNP
rs1417781495 168 dbSNP
rs182070261 180 dbSNP
rs1473066370 189 dbSNP
rs1176858529 194 dbSNP
rs1405803564 197 dbSNP
rs539451377 200 dbSNP
rs1029198790 202 dbSNP
rs968306031 209 dbSNP
rs979590164 210 dbSNP
rs113504941 212 dbSNP
rs893283946 214 dbSNP
rs28924704 216 dbSNP
rs1290091107 218 dbSNP
rs573957460 224 dbSNP
rs1292607729 228 dbSNP
rs1353560192 228 dbSNP
rs992664465 229 dbSNP
rs1352173064 231 dbSNP
rs1305918064 236 dbSNP
rs571184276 242 dbSNP
rs538407844 248 dbSNP
rs947572880 252 dbSNP
rs556754272 262 dbSNP
rs1350709602 269 dbSNP
rs1433221360 273 dbSNP
rs1310282184 276 dbSNP
rs574819102 284 dbSNP
rs1376274000 285 dbSNP
rs1160642152 287 dbSNP
rs28924705 294 dbSNP
rs1002871328 296 dbSNP
rs1045127666 302 dbSNP
rs562991156 302 dbSNP
rs1478540060 304 dbSNP
rs28631374 307 dbSNP
rs1219376742 311 dbSNP
rs186604547 314 dbSNP
rs1302573267 323 dbSNP
rs539325173 339 dbSNP
rs58749938 339 dbSNP
rs897161394 339 dbSNP
rs993782397 339 dbSNP
rs116651066 344 dbSNP
rs1207001355 345 dbSNP
rs755183763 353 dbSNP
rs1276890123 355 dbSNP
rs1275021026 357 dbSNP
rs951829534 359 dbSNP
rs984645662 363 dbSNP
rs1231457691 366 dbSNP
rs1048865698 367 dbSNP
rs1191893484 375 dbSNP
rs1387137174 377 dbSNP
rs879104438 378 dbSNP
rs1158937056 385 dbSNP
rs371315141 394 dbSNP
rs1427679537 402 dbSNP
rs531853724 410 dbSNP
rs1452149741 413 dbSNP
rs1251888998 427 dbSNP
rs1453074478 428 dbSNP
rs779014861 430 dbSNP
rs1171060200 432 dbSNP
rs1258897227 433 dbSNP
rs886286440 436 dbSNP
rs1312626347 438 dbSNP
rs1004748345 442 dbSNP
rs922888679 448 dbSNP
rs1040508869 450 dbSNP
rs748458117 457 dbSNP
rs1347460656 461 dbSNP
rs545793167 470 dbSNP
rs988991788 477 dbSNP
rs1363046373 478 dbSNP
rs28924706 478 dbSNP
rs1436548845 481 dbSNP
rs1449388579 483 dbSNP
rs1361299139 486 dbSNP
rs545572893 493 dbSNP
rs1174369209 497 dbSNP
rs1434435497 499 dbSNP
rs754374983 501 dbSNP
rs1168762443 502 dbSNP
rs1368192251 502 dbSNP
rs1259051628 503 dbSNP
rs575947891 504 dbSNP
rs1483524923 509 dbSNP
rs1230442363 516 dbSNP
rs140766904 517 dbSNP
rs565503561 523 dbSNP
rs1338497703 524 dbSNP
rs1346803627 526 dbSNP
rs1212645819 528 dbSNP
rs561946979 534 dbSNP
rs1305902080 544 dbSNP
rs968230835 560 dbSNP
rs528975497 561 dbSNP
rs897124841 562 dbSNP
rs1414554785 563 dbSNP
rs566732675 563 dbSNP
rs1467205862 566 dbSNP
rs1190990960 567 dbSNP
rs559495221 573 dbSNP
rs28924707 578 dbSNP
rs1370892843 579 dbSNP
rs1169164159 580 dbSNP
rs887733237 602 dbSNP
rs992360455 603 dbSNP
rs1415883220 617 dbSNP
rs191465491 621 dbSNP
rs969493385 622 dbSNP
rs571146353 629 dbSNP
rs1405555831 632 dbSNP
rs1485253549 637 dbSNP
rs980730482 639 dbSNP
rs1207606160 645 dbSNP
rs768611108 646 dbSNP
rs930550765 648 dbSNP
rs1391562084 653 dbSNP
rs28924708 660 dbSNP
rs1323508618 664 dbSNP
rs1291993470 666 dbSNP
rs1030093027 677 dbSNP
rs1351530729 681 dbSNP
rs1290576767 683 dbSNP
rs955882953 686 dbSNP
rs1325833372 687 dbSNP
rs1393921965 695 dbSNP
rs907809161 697 dbSNP
rs1457985196 700 dbSNP
rs550106270 709 dbSNP
rs1162782931 715 dbSNP
rs1285692479 719 dbSNP
rs1474819833 722 dbSNP
rs940517476 729 dbSNP
rs368082661 733 dbSNP
rs1356812181 740 dbSNP
rs1234069367 743 dbSNP
rs1272789137 749 dbSNP
rs568679602 750 dbSNP
rs1210599055 752 dbSNP
rs28924709 760 dbSNP
rs1271318593 765 dbSNP
rs145244215 769 dbSNP
rs572226471 772 dbSNP
rs539411359 779 dbSNP
rs1285553786 781 dbSNP
rs1446975626 796 dbSNP
rs968977974 798 dbSNP
rs1335489422 803 dbSNP
rs557763825 811 dbSNP
rs1191711231 814 dbSNP
rs1239533091 820 dbSNP
rs1372586050 822 dbSNP
rs980331559 823 dbSNP
rs1475740101 846 dbSNP
rs995884180 849 dbSNP
rs575908831 851 dbSNP
rs1050025769 853 dbSNP
rs1186771369 854 dbSNP
rs903542230 862 dbSNP
rs559226022 863 dbSNP
rs938882410 865 dbSNP
rs772367864 867 dbSNP
rs1451375445 878 dbSNP
rs1000566029 884 dbSNP
rs1199901530 886 dbSNP
rs1031650810 891 dbSNP
rs774917321 894 dbSNP
rs1159306850 904 dbSNP
rs929958870 908 dbSNP
rs1465352181 917 dbSNP
rs1383657245 918 dbSNP
rs1398829497 921 dbSNP
rs1350499002 925 dbSNP
rs1336107834 926 dbSNP
rs1048459906 927 dbSNP
rs1256920552 927 dbSNP
rs888455986 927 dbSNP
rs748812390 928 dbSNP
rs1340778249 932 dbSNP
rs1025152087 933 dbSNP
rs1414012967 936 dbSNP
rs79270561 937 dbSNP
rs1172968094 939 dbSNP
rs1436313082 940 dbSNP
rs773872644 943 dbSNP
rs900302682 944 dbSNP
rs1173190073 948 dbSNP
rs1450236239 950 dbSNP
rs1249981411 953 dbSNP
rs1191722860 956 dbSNP
rs980868140 957 dbSNP
rs761567877 961 dbSNP
rs1202581690 965 dbSNP
rs1484855941 973 dbSNP
rs952804712 974 dbSNP
rs1233092590 976 dbSNP
rs561722031 980 dbSNP
rs1261347876 992 dbSNP
rs982843357 993 dbSNP
rs1009852813 998 dbSNP
rs907776157 1002 dbSNP
rs1281426803 1008 dbSNP
rs1325817948 1009 dbSNP
rs1334663325 1026 dbSNP
rs1130596 1031 dbSNP
rs1416407771 1043 dbSNP
rs182514242 1048 dbSNP
rs1486194401 1049 dbSNP
rs1210675156 1062 dbSNP
rs1312576461 1067 dbSNP
rs940627864 1069 dbSNP
rs879632633 1071 dbSNP
rs975847938 1071 dbSNP
rs980300874 1071 dbSNP
rs1034620549 1076 dbSNP
rs923125094 1081 dbSNP
rs1190627597 1088 dbSNP
rs540891044 1090 dbSNP
rs1209760468 1099 dbSNP
rs1362653976 1106 dbSNP
rs1468160980 1107 dbSNP
rs1050120808 1112 dbSNP
rs1274625704 1132 dbSNP
rs903633952 1135 dbSNP
rs936329868 1142 dbSNP
rs1338107344 1144 dbSNP
rs930009733 1147 dbSNP
rs984206289 1150 dbSNP
rs559456738 1157 dbSNP
rs1049464 1161 dbSNP
rs942688625 1162 dbSNP
rs1039348693 1172 dbSNP
rs767751504 1172 dbSNP
rs1327024423 1175 dbSNP
rs1013857763 1183 dbSNP
rs933149738 1184 dbSNP
rs1167824371 1195 dbSNP
rs1474495157 1203 dbSNP
rs1417712653 1206 dbSNP
rs1025120853 1220 dbSNP
rs185505430 1240 dbSNP
rs905349508 1243 dbSNP
rs1183392086 1246 dbSNP
rs1471323448 1250 dbSNP
rs1002399287 1252 dbSNP
rs189822216 1256 dbSNP
rs56344098 1257 dbSNP
rs983156561 1258 dbSNP
rs1411851680 1259 dbSNP
rs1215534517 1269 dbSNP
rs1015598749 1276 dbSNP
rs1332620535 1283 dbSNP
rs397743123 1285 dbSNP
rs5893804 1285 dbSNP
rs200227859 1286 dbSNP
rs201233402 1287 dbSNP
rs79754172 1288 dbSNP
rs146380188 1291 dbSNP
rs1021349760 1294 dbSNP
rs1335237731 1296 dbSNP
rs962245625 1301 dbSNP
rs975983770 1311 dbSNP
rs1237042845 1322 dbSNP
rs923219739 1331 dbSNP
rs1278062733 1333 dbSNP
rs754754744 1333 dbSNP
rs1441748413 1336 dbSNP
rs931797472 1339 dbSNP
rs1331794016 1348 dbSNP
rs766996204 1350 dbSNP
rs28924710 1353 dbSNP
rs550410856 1390 dbSNP
rs1394400105 1393 dbSNP
rs753910286 1396 dbSNP
rs765422144 1397 dbSNP
rs1352828117 1400 dbSNP
rs1278571059 1405 dbSNP
rs1484249052 1409 dbSNP
rs960352625 1410 dbSNP
rs1156483759 1428 dbSNP
rs1469285841 1434 dbSNP
rs1195953856 1438 dbSNP
rs752826932 1441 dbSNP
rs1466701895 1445 dbSNP
rs892145941 1449 dbSNP
rs1435556592 1456 dbSNP
rs766779391 1458 dbSNP
rs1025771277 1463 dbSNP
rs1318575047 1466 dbSNP
rs1281846410 1473 dbSNP
rs949063005 1474 dbSNP
rs368490224 1476 dbSNP
rs951543422 1482 dbSNP
rs984174703 1490 dbSNP
rs1370317544 1492 dbSNP
rs1321882027 1496 dbSNP
rs367607788 1497 dbSNP
rs1453686100 1498 dbSNP
rs909994562 1504 dbSNP
rs189128037 1509 dbSNP
rs975477212 1513 dbSNP
rs905483361 1522 dbSNP
rs921839095 1526 dbSNP
rs780814994 1531 dbSNP
rs1175068402 1536 dbSNP
rs1452094941 1543 dbSNP
rs1393954274 1544 dbSNP
rs1052120961 1547 dbSNP
rs1002365171 1548 dbSNP
rs1486794655 1565 dbSNP
rs1027164965 1568 dbSNP
rs945898003 1569 dbSNP
rs1396102060 1575 dbSNP
rs888491156 1579 dbSNP
rs1347290333 1581 dbSNP
rs1298390290 1583 dbSNP
rs1325561501 1583 dbSNP
rs1371843234 1586 dbSNP
rs1234127421 1588 dbSNP
rs1216350339 1590 dbSNP
rs1042775476 1593 dbSNP
rs1301886766 1594 dbSNP
rs904305587 1599 dbSNP
rs1001605566 1611 dbSNP
rs1033986268 1611 dbSNP
rs1004317791 1613 dbSNP
rs1374372491 1618 dbSNP
rs1228687398 1623 dbSNP
rs529460168 1625 dbSNP
rs12542906 1626 dbSNP
rs759875148 1630 dbSNP
rs1211300964 1648 dbSNP
rs1253030719 1650 dbSNP
rs547598308 1653 dbSNP
rs1259312694 1654 dbSNP
rs1467653077 1665 dbSNP
rs1485478585 1668 dbSNP
rs1252066164 1669 dbSNP
rs1191602079 1672 dbSNP
rs1249878316 1674 dbSNP
rs1206726964 1677 dbSNP
rs1305785631 1697 dbSNP
rs1428868396 1710 dbSNP
rs1017025190 1715 dbSNP
rs765540732 1716 dbSNP
rs1291797596 1724 dbSNP
rs1460613011 1725 dbSNP
rs964160738 1727 dbSNP
rs58367828 1736 dbSNP
rs1463120953 1738 dbSNP
rs745671177 1739 dbSNP
rs1352253676 1751 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cccAGGGAGAGGU-UUACACAGa 5'
             |:||||  || | |||||| 
Target 5' uauUUCCUCAACAUACUGUGUCa 3'
 		3 - 25
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000312046.6 | 3UTR | CAUAUUUCCUCAACAUACUGUGUCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
Click to see details
77 hsa-miR-642b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT082888 ZNF543 zinc finger protein 543 2 2
MIRT108294 BHLHB9 basic helix-loop-helix family member b9 2 2
MIRT348737 ZNF350 zinc finger protein 350 2 2
MIRT381384 EXOG exo/endonuclease G 2 2
MIRT452245 TRAM1 translocation associated membrane protein 1 2 2
MIRT459262 ADRBK1 G protein-coupled receptor kinase 2 2 2
MIRT468117 SH3PXD2A SH3 and PX domains 2A 2 2
MIRT468402 SETD3 SET domain containing 3 2 2
MIRT469079 RNF168 ring finger protein 168 2 2
MIRT471690 OXR1 oxidation resistance 1 2 2
MIRT477353 EOGT EGF domain specific O-linked N-acetylglucosamine transferase 2 4
MIRT479600 CDC25B cell division cycle 25B 2 2
MIRT482377 AFF4 AF4/FMR2 family member 4 2 4
MIRT484029 LARP4B La ribonucleoprotein domain family member 4B 2 2
MIRT490988 USP22 ubiquitin specific peptidase 22 2 2
MIRT493250 MEF2D myocyte enhancer factor 2D 2 2
MIRT493850 FOXN3 forkhead box N3 2 4
MIRT496086 C17orf85 nuclear cap binding subunit 3 2 2
MIRT500630 TXNIP thioredoxin interacting protein 2 2
MIRT501048 SMEK1 protein phosphatase 4 regulatory subunit 3A 2 2
MIRT525186 ZNF257 zinc finger protein 257 2 4
MIRT534875 QSER1 glutamine and serine rich 1 2 2
MIRT539336 AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 2 2
MIRT553814 SYNCRIP synaptotagmin binding cytoplasmic RNA interacting protein 2 2
MIRT555959 NRAS NRAS proto-oncogene, GTPase 2 2
MIRT556289 MAP3K5 mitogen-activated protein kinase kinase kinase 5 2 2
MIRT561212 ZSWIM1 zinc finger SWIM-type containing 1 2 2
MIRT567328 HMGB1 high mobility group box 1 2 2
MIRT572385 LRRC6 leucine rich repeat containing 6 2 2
MIRT575529 Map4 microtubule-associated protein 4 2 2
MIRT575684 Map1b microtubule-associated protein 1B 2 2
MIRT576828 Tgfbr3 transforming growth factor, beta receptor III 2 2
MIRT576953 Pigs phosphatidylinositol glycan anchor biosynthesis, class S 2 3
MIRT608316 SYK spleen associated tyrosine kinase 2 4
MIRT609794 PINX1 PIN2/TERF1 interacting telomerase inhibitor 1 2 2
MIRT609991 PIGS phosphatidylinositol glycan anchor biosynthesis class S 2 3
MIRT611381 PNMAL1 paraneoplastic Ma antigen family member 8A 2 4
MIRT613566 YY2 YY2 transcription factor 2 2
MIRT614612 MVK mevalonate kinase 2 2
MIRT615497 MPP2 membrane palmitoylated protein 2 2 2
MIRT616941 OTUD7A OTU deubiquitinase 7A 2 2
MIRT617576 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT618214 SPTLC3 serine palmitoyltransferase long chain base subunit 3 2 4
MIRT619885 ABHD17B abhydrolase domain containing 17B 2 2
MIRT620401 MYO1H myosin IH 2 2
MIRT620517 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT622166 SMYD1 SET and MYND domain containing 1 2 2
MIRT623195 MTX3 metaxin 3 2 2
MIRT623440 KIAA0408 KIAA0408 2 4
MIRT624837 ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 2 2
MIRT625706 SHROOM1 shroom family member 1 2 2
MIRT628159 HIP1 huntingtin interacting protein 1 2 2
MIRT629496 SGIP1 SH3 domain GRB2 like endophilin interacting protein 1 2 2
MIRT630240 SOGA3 SOGA family member 3 2 4
MIRT630521 BAZ2A bromodomain adjacent to zinc finger domain 2A 2 4
MIRT635676 COX18 COX18, cytochrome c oxidase assembly factor 2 4
MIRT637820 CACNA1B calcium voltage-gated channel subunit alpha1 B 2 2
MIRT637943 SIGLEC9 sialic acid binding Ig like lectin 9 2 2
MIRT640490 EXOC5 exocyst complex component 5 2 2
MIRT642722 ATXN3 ataxin 3 2 2
MIRT649153 LRTM1 leucine rich repeats and transmembrane domains 1 2 2
MIRT649610 ITPKC inositol-trisphosphate 3-kinase C 2 2
MIRT661016 ABCA12 ATP binding cassette subfamily A member 12 2 2
MIRT661055 RPL18A ribosomal protein L18a 2 2
MIRT684041 FOLR1 folate receptor 1 2 2
MIRT691014 CRTC3 CREB regulated transcription coactivator 3 2 2
MIRT698908 SPPL2A signal peptide peptidase like 2A 2 2
MIRT700981 PDE4D phosphodiesterase 4D 2 2
MIRT701722 MTMR12 myotubularin related protein 12 2 2
MIRT702724 INSIG1 insulin induced gene 1 2 2
MIRT705057 C5orf15 chromosome 5 open reading frame 15 2 2
MIRT705216 BRWD1 bromodomain and WD repeat domain containing 1 2 2
MIRT706088 HNRNPU heterogeneous nuclear ribonucleoprotein U 2 2
MIRT709458 KRTAP19-1 keratin associated protein 19-1 2 2
MIRT711396 RANBP2 RAN binding protein 2 2 2
MIRT720573 SDHAF2 succinate dehydrogenase complex assembly factor 2 2 2
MIRT725366 MTF2 metal response element binding transcription factor 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-642b-3p Platinum-based doublet chemotherapy sensitive High Lung Adenocarcinoma tissue
hsa-miR-642b-3p Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-642b-3p Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-642b-3p Sunitinib 5329102 NSC750690 approved resistant Low Renal Cell Cancer cell line (ACHN, RCC23)
hsa-miR-642b-3p Paclitaxel 36314 NSC125973 approved sensitive High Ovarian Cancer cell line (HEYA8)
hsa-miR-642b-3p Fluorouracil 3385 NSC19893 approved resistant High Colorectal Cancer cell line (HT-29)
hsa-miR-642b-3p Platinum 23939 sensitive High High-Grade Serous Ovarian Cancer tissue
hsa-miR-642b-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-642b-3p Platinum-based doublet chemotherapy sensitive tissue (lung adenocarcinoma)
hsa-miR-642b-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-642b-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-642b-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-642b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (OVSAHO)

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