miRTarBase - #MIRT471906


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pre-miRNA Information
pre-miRNA hsa-mir-4464   
Genomic Coordinates chr6: 90312742 - 90312833
Description Homo sapiens miR-4464 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4464
Sequence 12| AAGGUUUGGAUAGAUGCAAUA |32
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 12 6 + 90312764 29233923 MiREDiBase
A-to-I 14 6 + 90312766 29233923 MiREDiBase
A-to-I 19 6 + 90312771 29233923 MiREDiBase
A-to-I 21 6 + 90312773 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1240632245 2 dbSNP
rs34899210 2 dbSNP
rs1003034046 13 dbSNP
rs1475351324 14 dbSNP
rs1257582329 17 dbSNP
rs1193587810 20 dbSNP
Putative Targets

Gene Information
Gene Symbol NUAK2   
Synonyms SNARK
Description NUAK family kinase 2
Transcript NM_030952   
Expression
Putative miRNA Targets on NUAK2
3'UTR of NUAK2
(miRNA target sites are highlighted)		 
>NUAK2|NM_030952|3'UTR
   1 GTGGAGTAGGCATTGCCCCAGCCCGGTCAGGCTCTCAGATGCAGCTGGTTGCACCCCGAGGGGAGATGCCTTCTCCCCCA
  81 CCTCCCAGGACCTGCATCCCAGCTCAGAAGGCTGAGAGGGTTTGCAGTGGAGCCCTGAGCAGGGCTGGATATGGGAAGTA
 161 GGCAAATGAAATGCGCCAAGGGTTCAGTGTCTGTCTTCAGCCCTGCTGAACGAAGAGGATACTAAAGAGAGGGGAACGGG
 241 AATGCCCGCGACAGAGTCCACATTGCCTGTTTCTTGTGTACATGGGGGGGCCACAGAGACCTGGAAAGAGAACTCTCCCA
 321 GGGCCCATCTCCTGCATCCCATGAATACTCTGTACACATGGTGCCTTCTAAGGACAGCTCCTTCCCTACTCATTCCCTGC
 401 CCAAGTGGGGCCAGACCTCTTTACACACACATTCCCGTTCCTACCAACCACCAGAACTGGATGGTGGCACCCCTAATGTG
 481 CATGAGGCATCCTGGGAATGGTCTGGAGTAACGCTTCGTTATTTTTATTTTTATTTTTATTTATTTATTTATTTTTTTGA
 561 GACGGAGTTTCGCTCTTGGTGCCCAGGCTAGAGTGCAATGGCGCGATCTCAGCTCACCTCAACCTCCGCCTCCCGGGTTC
 641 AAGCGATTCTCCTGCCTCAGCCTCCCTAGTAGCTGGGATTACAGGCGCCCGCCACCATGCCCGGCTAATTTTGTATTTTT
 721 AGTAGAGACAGGGTTTCTCCATGTTGGTCAGGCTGGTCTCAAACTCCCGACCTCAGGTGATCCACCCACCTCGGCCTCCC
 801 AAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCCACCTAACCCTTCCTTATTTAGCCTAGGAGTAAGAGAACACAAT
 881 CTCTGTTTCTTCAATGGTTCTCTTCCCTTTTCCATCCTCCAAACCTGGCCTGAGCCTCCTGAAGTTGCTGCTGTGAATCT
 961 GAAAGACTTGAAAAGCCTCCGCCTGCTGTGTGGACTTCATCTCAAGGGGCCCAGCCTCCTCTGGACTCCACCTTGGACCT
1041 CAGTGACTCAGAACTTCTGCCTCTAAGCTGCTCTAAAGTCCAGACTATGGATGTGTTCTCTAGGCCTTCAGGACTCTAGA
1121 ATGTCCATATTTATTTTTATGTTCTTGGCTTTGTGTTTTAGGAAAAGTGAATCTTGCTGTTTTCAATAATGTGAATGCTA
1201 TGTTCTGGGAAAATCCACTATGACATCTAAGTTTTGTGTACAGAGAGATATTTTTGCAACTATTTCCACCTCCTCCCACA
1281 ACCCCCCACACTCCACTCCACACTCTTGAGTCTCTTTACCTAATGGTCTCTACCTAATGGACCTCCGTGGCCAAAAAGTA
1361 CCATTAAAACCAGAAAGGTGATTGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' auAACGUAGAUAGGUUUGGAa 5'
            || ||||  ||||||||| 
Target 5' ttTTCCATC-CTCCAAACCTg 3'
 908 - 927 166.00 -14.80
2 
miRNA  3' auaacguagauaGGUUUGGAa 5'
                      |||:|||| 
Target 5' gcccaagtggggCCAGACCTc 3'
 399 - 419 129.00 -15.80
3 
miRNA  3' auaaCGUAGAUAG--GUUUGGAa 5'
              |::|||:||  ||: ||| 
Target 5' ttcaGTGTCTGTCTTCAGCCCTg 3'
 183 - 205 115.00 -11.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN13510492 25 COSMIC
COSN30540031 32 COSMIC
COSN8637348 58 COSMIC
COSN30100647 61 COSMIC
COSN30452439 75 COSMIC
COSN30469233 110 COSMIC
COSN28860237 171 COSMIC
COSN9057329 183 COSMIC
COSN31589238 211 COSMIC
COSN26002972 750 COSMIC
COSN1096562 860 COSMIC
COSN30170751 981 COSMIC
COSN26585434 1016 COSMIC
COSN30539583 1028 COSMIC
COSN8429660 1068 COSMIC
COSN26561343 1089 COSMIC
COSN31959492 1091 COSMIC
COSN28720967 1102 COSMIC
COSN31528504 1174 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1374521955 6 dbSNP
rs1289606093 15 dbSNP
rs576897259 18 dbSNP
rs368978407 19 dbSNP
rs1394095863 20 dbSNP
rs1165895991 23 dbSNP
rs369572763 24 dbSNP
rs200122171 25 dbSNP
rs749878352 27 dbSNP
rs1418372897 28 dbSNP
rs1380691956 32 dbSNP
rs780506107 34 dbSNP
rs529806068 39 dbSNP
rs752520162 42 dbSNP
rs756550788 42 dbSNP
rs1031353743 53 dbSNP
rs574970034 57 dbSNP
rs12080581 58 dbSNP
rs1391309737 64 dbSNP
rs1388426313 70 dbSNP
rs1167441642 76 dbSNP
rs535031953 78 dbSNP
rs1008131286 79 dbSNP
rs71568044 80 dbSNP
rs1218317439 82 dbSNP
rs970423135 86 dbSNP
rs777716299 96 dbSNP
rs1023524029 114 dbSNP
rs890671547 115 dbSNP
rs1012165121 116 dbSNP
rs1052243937 118 dbSNP
rs1225360512 119 dbSNP
rs929403009 136 dbSNP
rs1237338425 140 dbSNP
rs1488133539 145 dbSNP
rs542900471 147 dbSNP
rs1193934576 152 dbSNP
rs757889462 158 dbSNP
rs1037685796 159 dbSNP
rs1163524263 166 dbSNP
rs1368510766 173 dbSNP
rs942060450 174 dbSNP
rs1156759085 175 dbSNP
rs999396471 181 dbSNP
rs776311596 188 dbSNP
rs903241377 201 dbSNP
rs909777511 203 dbSNP
rs1041806707 212 dbSNP
rs1227805327 221 dbSNP
rs1394478102 226 dbSNP
rs41264875 231 dbSNP
rs890448209 232 dbSNP
rs1050425313 235 dbSNP
rs948520434 237 dbSNP
rs552163507 238 dbSNP
rs369138360 240 dbSNP
rs920872721 247 dbSNP
rs16855350 248 dbSNP
rs569713665 249 dbSNP
rs1180922993 250 dbSNP
rs955791951 266 dbSNP
rs1031447036 276 dbSNP
rs940888260 278 dbSNP
rs1306951615 280 dbSNP
rs1357206580 282 dbSNP
rs978408370 284 dbSNP
rs1302419249 285 dbSNP
rs7550061 286 dbSNP
rs180705035 289 dbSNP
rs1256156693 291 dbSNP
rs1309693999 291 dbSNP
rs376692630 291 dbSNP
rs957929235 291 dbSNP
rs990510291 291 dbSNP
rs1462293612 298 dbSNP
rs561754614 304 dbSNP
rs1429674367 306 dbSNP
rs1236999449 307 dbSNP
rs1440313641 309 dbSNP
rs1417750912 312 dbSNP
rs1186286589 314 dbSNP
rs890588042 318 dbSNP
rs1030515054 320 dbSNP
rs1258494340 324 dbSNP
rs1204630780 345 dbSNP
rs999724998 349 dbSNP
rs966575425 354 dbSNP
rs1019897548 357 dbSNP
rs1253215684 359 dbSNP
rs1329443469 360 dbSNP
rs1205279852 363 dbSNP
rs1448248354 364 dbSNP
rs1321069190 366 dbSNP
rs539882334 367 dbSNP
rs548318708 369 dbSNP
rs1365934861 380 dbSNP
rs993521110 388 dbSNP
rs897897236 389 dbSNP
rs140643045 392 dbSNP
rs1050372434 395 dbSNP
rs942029188 399 dbSNP
rs1287470915 404 dbSNP
rs996144994 406 dbSNP
rs1389382382 407 dbSNP
rs191434647 410 dbSNP
rs186529414 428 dbSNP
rs948677487 434 dbSNP
rs778848322 436 dbSNP
rs546115144 437 dbSNP
rs992640720 440 dbSNP
rs949100296 441 dbSNP
rs1436363454 458 dbSNP
rs916365221 460 dbSNP
rs1163322183 469 dbSNP
rs1347761170 475 dbSNP
rs532171634 488 dbSNP
rs934507909 499 dbSNP
rs1277100052 506 dbSNP
rs1463358580 508 dbSNP
rs563260815 512 dbSNP
rs978544129 513 dbSNP
rs543171792 514 dbSNP
rs1287103182 515 dbSNP
rs968752961 517 dbSNP
rs572111212 518 dbSNP
rs957693416 524 dbSNP
rs986761187 525 dbSNP
rs925155586 529 dbSNP
rs978024347 531 dbSNP
rs554867791 539 dbSNP
rs1262695542 543 dbSNP
rs1405353180 543 dbSNP
rs1411711554 543 dbSNP
rs1475797123 543 dbSNP
rs61237434 543 dbSNP
rs1164708912 547 dbSNP
rs1030566174 550 dbSNP
rs993614000 551 dbSNP
rs1398494665 552 dbSNP
rs1008506195 554 dbSNP
rs1029053233 555 dbSNP
rs1281992670 555 dbSNP
rs1340793136 555 dbSNP
rs954763719 555 dbSNP
rs1228837219 559 dbSNP
rs996095725 559 dbSNP
rs898033130 560 dbSNP
rs1038141801 563 dbSNP
rs1016300270 564 dbSNP
rs113141903 571 dbSNP
rs905162916 572 dbSNP
rs1045089716 575 dbSNP
rs1014026468 579 dbSNP
rs1472470383 584 dbSNP
rs1236587812 588 dbSNP
rs1387572663 590 dbSNP
rs1418383329 591 dbSNP
rs1158457311 597 dbSNP
rs1386132895 599 dbSNP
rs867048974 602 dbSNP
rs895718723 603 dbSNP
rs760927282 604 dbSNP
rs577496967 605 dbSNP
rs924439553 607 dbSNP
rs1317105015 611 dbSNP
rs1374639440 624 dbSNP
rs1042796267 627 dbSNP
rs201753207 628 dbSNP
rs1207124348 631 dbSNP
rs947172808 634 dbSNP
rs554108907 635 dbSNP
rs377296358 636 dbSNP
rs954557612 644 dbSNP
rs1158373139 645 dbSNP
rs1178558829 650 dbSNP
rs1452027106 651 dbSNP
rs923517676 660 dbSNP
rs1471326151 661 dbSNP
rs1365763570 667 dbSNP
rs181290944 670 dbSNP
rs1469975849 676 dbSNP
rs1338182569 677 dbSNP
rs1453978798 679 dbSNP
rs1251287260 680 dbSNP
rs190131521 682 dbSNP
rs538929250 686 dbSNP
rs184457752 687 dbSNP
rs1260902186 688 dbSNP
rs969479047 689 dbSNP
rs181995251 690 dbSNP
rs1013578846 691 dbSNP
rs11580336 693 dbSNP
rs567708627 694 dbSNP
rs998782182 695 dbSNP
rs1345290070 696 dbSNP
rs902992261 698 dbSNP
rs1197259537 700 dbSNP
rs189297342 701 dbSNP
rs1042914972 702 dbSNP
rs947233723 703 dbSNP
rs936438166 707 dbSNP
rs1464611979 713 dbSNP
rs1168447765 715 dbSNP
rs1015411803 722 dbSNP
rs1380898903 723 dbSNP
rs1387662866 730 dbSNP
rs1289808487 731 dbSNP
rs1434378274 738 dbSNP
rs1393475935 740 dbSNP
rs1175629694 741 dbSNP
rs1398604679 747 dbSNP
rs1454736045 758 dbSNP
rs1384972376 760 dbSNP
rs528333088 761 dbSNP
rs910290082 768 dbSNP
rs565857104 769 dbSNP
rs1448648332 770 dbSNP
rs1285362031 772 dbSNP
rs1262249797 776 dbSNP
rs932999748 782 dbSNP
rs765816171 784 dbSNP
rs922943348 788 dbSNP
rs552535158 790 dbSNP
rs972260390 792 dbSNP
rs1210983343 793 dbSNP
rs1338108934 795 dbSNP
rs912481889 804 dbSNP
rs559889014 808 dbSNP
rs1260527932 815 dbSNP
rs532415997 816 dbSNP
rs962288184 820 dbSNP
rs1328673404 821 dbSNP
rs986626598 824 dbSNP
rs575038327 830 dbSNP
rs41264873 831 dbSNP
rs1305215796 832 dbSNP
rs969992829 833 dbSNP
rs543361790 834 dbSNP
rs117996356 839 dbSNP
rs1222147953 846 dbSNP
rs1291638651 850 dbSNP
rs769791884 854 dbSNP
rs745834209 856 dbSNP
rs1360645563 860 dbSNP
rs183778252 863 dbSNP
rs1284280197 866 dbSNP
rs960660516 870 dbSNP
rs561079957 875 dbSNP
rs796117747 879 dbSNP
rs1263233536 882 dbSNP
rs1421477863 885 dbSNP
rs1186794031 889 dbSNP
rs903085892 893 dbSNP
rs142015290 895 dbSNP
rs886666759 902 dbSNP
rs1359659614 912 dbSNP
rs1453393191 913 dbSNP
rs1289609687 934 dbSNP
rs191599276 944 dbSNP
rs545115312 959 dbSNP
rs770681249 965 dbSNP
rs1314438901 966 dbSNP
rs1384235188 970 dbSNP
rs1248794161 971 dbSNP
rs1025668436 980 dbSNP
rs370935768 981 dbSNP
rs1050142854 984 dbSNP
rs1186994817 985 dbSNP
rs895307455 987 dbSNP
rs1482004229 988 dbSNP
rs933078936 994 dbSNP
rs148084502 995 dbSNP
rs903628736 1010 dbSNP
rs1436853377 1011 dbSNP
rs1176688038 1016 dbSNP
rs1379471002 1029 dbSNP
rs1419409244 1030 dbSNP
rs1270319208 1032 dbSNP
rs1160134806 1035 dbSNP
rs1042025724 1040 dbSNP
rs1464705779 1043 dbSNP
rs1336232823 1046 dbSNP
rs1406898482 1047 dbSNP
rs377718591 1063 dbSNP
rs1329822214 1073 dbSNP
rs1035967984 1074 dbSNP
rs538628158 1075 dbSNP
rs1224639893 1076 dbSNP
rs945053915 1088 dbSNP
rs1310121294 1091 dbSNP
rs12079090 1093 dbSNP
rs909458957 1095 dbSNP
rs1462223240 1098 dbSNP
rs1196682254 1099 dbSNP
rs1232182235 1100 dbSNP
rs986688446 1114 dbSNP
rs985484244 1117 dbSNP
rs1342111651 1119 dbSNP
rs1178769029 1127 dbSNP
rs932604481 1128 dbSNP
rs1479610093 1133 dbSNP
rs1175894353 1139 dbSNP
rs948204786 1139 dbSNP
rs1259225369 1140 dbSNP
rs1354520242 1144 dbSNP
rs1233066288 1145 dbSNP
rs747589974 1146 dbSNP
rs1300343104 1148 dbSNP
rs992229456 1157 dbSNP
rs1403971042 1161 dbSNP
rs960802654 1164 dbSNP
rs1031116876 1171 dbSNP
rs1325097581 1174 dbSNP
rs1216306060 1176 dbSNP
rs1415699160 1185 dbSNP
rs978076046 1190 dbSNP
rs1271638189 1193 dbSNP
rs1308070577 1200 dbSNP
rs973902869 1202 dbSNP
rs963484328 1204 dbSNP
rs1335367086 1206 dbSNP
rs1490105802 1208 dbSNP
rs1269813177 1221 dbSNP
rs1481529762 1224 dbSNP
rs187823415 1237 dbSNP
rs1021540674 1242 dbSNP
rs1011911373 1249 dbSNP
rs1173097727 1257 dbSNP
rs1348508409 1267 dbSNP
rs888922102 1282 dbSNP
rs983449944 1284 dbSNP
rs1347049254 1286 dbSNP
rs1029261451 1287 dbSNP
rs778357148 1290 dbSNP
rs778425709 1290 dbSNP
rs1269134501 1302 dbSNP
rs1361968009 1308 dbSNP
rs1216261392 1318 dbSNP
rs1287591784 1323 dbSNP
rs768121420 1328 dbSNP
rs755426364 1339 dbSNP
rs1358491252 1342 dbSNP
rs901586663 1346 dbSNP
rs184907170 1347 dbSNP
rs1419846976 1354 dbSNP
rs1213896819 1360 dbSNP
rs1241613570 1363 dbSNP
rs940357549 1366 dbSNP
rs887441489 1368 dbSNP
rs1469350815 1372 dbSNP
rs570269926 1376 dbSNP
rs1183394171 1377 dbSNP
rs758544471 1384 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' auAACGUAGAUAGGUUUGGAa 5'
            || ||||  ||||||||| 
Target 5' uuUUCCAUC-CUCCAAACCUg 3'
 		11 - 30
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000367157.3 | 3UTR | UUCUCUUCCCUUUUCCAUCCUCCAAACCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
81 hsa-miR-4464 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT056004 ARL5B ADP ribosylation factor like GTPase 5B 2 2
MIRT061568 BTG2 BTG anti-proliferation factor 2 2 2
MIRT078651 ICT1 mitochondrial ribosomal protein L58 2 2
MIRT087551 YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta 2 4
MIRT088139 SEPT2 septin 2 2 4
MIRT095089 SEC24A SEC24 homolog A, COPII coat complex component 2 4
MIRT099065 FOXC1 forkhead box C1 2 4
MIRT150194 MIDN midnolin 2 2
MIRT178173 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 4
MIRT178942 C11ORF57 chromosome 11 open reading frame 57 2 2
MIRT188776 SESN2 sestrin 2 2 2
MIRT267026 EFHD2 EF-hand domain family member D2 2 2
MIRT307213 ACVR2B activin A receptor type 2B 2 2
MIRT324750 ACER2 alkaline ceramidase 2 2 2
MIRT442732 TEAD1 TEA domain transcription factor 1 2 2
MIRT444087 C12orf73 chromosome 12 open reading frame 73 2 2
MIRT445527 KLF9 Kruppel like factor 9 2 2
MIRT449604 INIP INTS3 and NABP interacting protein 2 2
MIRT451129 ZNF99 zinc finger protein 99 2 2
MIRT452271 RPL30 ribosomal protein L30 2 2
MIRT452486 DDX4 DEAD-box helicase 4 2 2
MIRT454868 DNAJC15 DnaJ heat shock protein family (Hsp40) member C15 2 6
MIRT455773 TSPAN6 tetraspanin 6 2 4
MIRT463844 WRN Werner syndrome RecQ like helicase 2 2
MIRT465036 TTC39C tetratricopeptide repeat domain 39C 2 2
MIRT465176 TRPV2 transient receptor potential cation channel subfamily V member 2 2 4
MIRT465294 TRIB3 tribbles pseudokinase 3 2 4
MIRT467931 SLC16A7 solute carrier family 16 member 7 2 2
MIRT471906 NUAK2 NUAK family kinase 2 2 2
MIRT472724 MTUS1 microtubule associated scaffold protein 1 2 6
MIRT479785 CCND1 cyclin D1 2 2
MIRT482446 ADM adrenomedullin 2 10
MIRT485365 MYLIP myosin regulatory light chain interacting protein 2 12
MIRT498399 KIF6 kinesin family member 6 2 2
MIRT503202 ACTB actin beta 2 6
MIRT503819 TMEM242 transmembrane protein 242 2 2
MIRT504706 ZNF117 zinc finger protein 117 2 2
MIRT507802 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT509968 KANSL1L KAT8 regulatory NSL complex subunit 1 like 2 4
MIRT517306 ELF4 E74 like ETS transcription factor 4 2 6
MIRT523900 ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 2 6
MIRT532018 NOX5 NADPH oxidase 5 2 2
MIRT535334 PHACTR2 phosphatase and actin regulator 2 2 2
MIRT536944 HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 2 4
MIRT539322 AHSA2 activator of HSP90 ATPase homolog 2 2 2
MIRT540189 GSTM4 glutathione S-transferase mu 4 2 2
MIRT545015 ZNF439 zinc finger protein 439 2 2
MIRT545265 TRIM36 tripartite motif containing 36 2 4
MIRT547230 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 4
MIRT548425 ELOVL5 ELOVL fatty acid elongase 5 2 2
MIRT549910 ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 2 2
MIRT550185 TMEM106C transmembrane protein 106C 2 2
MIRT550775 ENOX2 ecto-NOX disulfide-thiol exchanger 2 2 4
MIRT552401 ZNF487P zinc finger protein 487 1 1
MIRT554782 RHEBP1 RHEB pseudogene 1 2 4
MIRT557311 HIF1A hypoxia inducible factor 1 alpha subunit 2 2
MIRT558635 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT563168 RPS14 ribosomal protein S14 2 2
MIRT564886 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon 2 2
MIRT565778 SEPHS1 selenophosphate synthetase 1 2 2
MIRT566480 PDCD4 programmed cell death 4 2 2
MIRT567206 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT568931 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 2
MIRT570698 FBXO41 F-box protein 41 2 2
MIRT573474 MTRNR2L9 MT-RNR2-like 9 2 2
MIRT576170 Hmox1 heme oxygenase 1 2 2
MIRT607555 GLI2 GLI family zinc finger 2 2 2
MIRT608203 ERBB2 erb-b2 receptor tyrosine kinase 2 2 2
MIRT609779 VWC2L von Willebrand factor C domain containing protein 2 like 2 4
MIRT616312 CELF2 CUGBP Elav-like family member 2 2 2
MIRT617190 CDH13 cadherin 13 2 2
MIRT626842 RPLP1 ribosomal protein lateral stalk subunit P1 2 2
MIRT636438 MARCH1 membrane associated ring-CH-type finger 1 2 2
MIRT639101 GLIPR1L2 GLI pathogenesis related 1 like 2 2 2
MIRT691018 CRTC3 CREB regulated transcription coactivator 3 2 2
MIRT700008 RPS21 ribosomal protein S21 2 2
MIRT701144 PANK1 pantothenate kinase 1 2 2
MIRT712691 NUDT7 nudix hydrolase 7 2 2
MIRT715505 MAZ MYC associated zinc finger protein 2 2
MIRT722509 PTPRC protein tyrosine phosphatase, receptor type C 2 2
MIRT724982 TNS1 tensin 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miR-4464 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4464 Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)

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