pre-miRNA Information
pre-miRNA hsa-mir-4477a   
Genomic Coordinates chr9: 41233755 - 41233835
Description Homo sapiens miR-4477a stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4477a
Sequence 48| CUAUUAAGGACAUUUGUGAUUC |69
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1281813060 1 dbSNP
rs1352899679 1 dbSNP
rs1283566158 2 dbSNP
rs1236244724 4 dbSNP
rs75019967 4 dbSNP
rs1348124293 5 dbSNP
rs34026740 8 dbSNP
rs1288237115 9 dbSNP
rs71262206 10 dbSNP
rs1355759977 11 dbSNP
rs1300249508 16 dbSNP
rs1328879592 18 dbSNP
rs139133717 20 dbSNP
Putative Targets

Gene Information
Gene Symbol NAPG   
Synonyms GAMMASNAP
Description NSF attachment protein gamma
Transcript NM_003826   
Expression
Putative miRNA Targets on NAPG
3'UTR of NAPG
(miRNA target sites are highlighted)
>NAPG|NM_003826|3'UTR
   1 TATTTTGCTTGCTGAAAAGAAAAGGGAAACAAAGGTAAAATCCTGACATGCCATTTCAAGGACTTGGGAATAGATTAGGG
  81 ATATCCGTACTTCATTACAGTCATGATTTTGGATCCTAATAAAGACTAGTTTTTAGTTACCATCTTCCCAAATCACTCAT
 161 TGTATCCATTACCTGTGAAGCATATCTTTTTCTTTCCATAAGAGCTTTTCTAAGACACCAGCAGGAATTAACAGAAAATG
 241 TACTGTCATGTTTTAATACATTGATTAAAAAATTTGCAAGCCAAATTATACATAAATTATGTTCTAAACAAAAGGGGTAA
 321 TAAGCATAGGTATTCTCTCTTGGACACTTGTAAGTTACTGTTAGTGAATTGTTTTTTACGTTTCATTTAATAATTGCTGC
 401 TAAAGGTGATGTTTACTGATAAATCATTTTAAAATTTTTTTGTTTTGAAAAGTAAATTTATCCCCCATGATGTTAGATAC
 481 ATTTAAATTATTAAGTCTTTTCAGAGATGAGATGGGGACAGGAAGTTATTTTGAGCCTTACAATATTATTTAGCCCAATA
 561 AAAGATGCATTGAAGCTCTTATATATTATGAGTTTGAAAAATTTTGAAGGTAGCATATTGAAGTGATCTATAAATATCTT
 641 CAGTCCTCTCTGAAGTGTGGGTATTTCTTCTATCTAAAAAATACATACAGTGACTGTCTTCAAATCTACTTGGTTCTTGA
 721 CCAAATAGGAGCTAATGGGTAATGAATACCTTTTTGTTTGTTTGTTTGTTTGTTTTGTTTTTTGTTTTTTTTTTTAAGGG
 801 TCTCACTCTTTTGCCCAGGCTGGAGTGCAGTGGCACAATCACGGCTCCCAGGCTAATGTTTTTATTTTTAATTTGTAATT
 881 TTTTTTTTATTTTTTTTGTTGAGATGGAGTTGCTCCATGTTGCACAGGCTGTTCTCAAACTCCTAAGCTCAAGCCATCTG
 961 CCTGCCTTGGCCTCCCAAAGTGCTGGGATTGTAGACATAAGCCACCTCACCCAGCCTATGAATATCTTTCTAACATTGTA
1041 AGAATGAGGTAATGTTTCCATCAGTCTAATACAGATATATTTCTTCCCTCCAAAACAGTTTATTTTGATTGTTTATTTTA
1121 TTTTGATTGTAACTCCGTCATAACTTGACATGGAAAATGCTATATACTATGAAAACTTAGCTGAAAGGGAAGAATTGTTT
1201 TAGAAAGACAATATTTAAAACACCGCACTGCCAATATATTGATCCTTTATAGTTATTTCCTAAAATGCTGTTTTCGAAAC
1281 ATTCCTTTTTCACCCTGTTGTGTGGCTTAGACCCATCTCGTAATCTGTTAATTGGAAAGAGGCTACAGACACCAGCAGTG
1361 TGCGTTCTGCAGGTACACGCTGCCAAAGTAATTCCTGCTCATCCATGCCCTGTCTCTGTCTCTTTTAGAGTCATACCTTA
1441 TTTGAGTATAGGTTGCTTAATTTTGCTAGACTTCCTGAAAACACTAAGGTGGAGTATCAGAAGTGATTTTAGTCACAGTT
1521 CTGCGGGAGAGCTTAGAATAACATCCTCCTTTGGGAGGTGGTCTCGGGTGCGTGGATGTTGGTATACAGTCTTTATTGTA
1601 AGTCTGATACAAAATGCTAATAAATTTAATGTTTTTCTTCCTTAATTTATTGGCATAGTTCTTCAGGTAGCACCTCATTT
1681 TTATTAATGATATTGGGATTAACTATGAACAAGCTATATGTAGACATTTGCATTTAAGGACATTGCAGTGTTTCAAAGAT
1761 CCCATCATTGCAGCTTGTATCCTTTAGATCCAATCGGAAACTTCTGGAGTCTTACATTAATGCTCATTTGAGCTAATTAG
1841 TAATCTGTTTAAACAGATTTGGCAATACTTTAAAGATACTGTAGACTATTTATGTATAGATAGATCATATTACCCATTAA
1921 AGTCTGGGGGAAAAAATTTTTTAATTTTACTCTTCTTATGTACTGAAAACTTTTTTTAAAAAAGGTGATGATGAAGTGCA
2001 TTCTGTAGCAGCAGCGCAGCTATGCTTTAAACCACACAAAAGGCTGTGTCCAGGTGCAGCCTCCTTCACCCTTCCTGCCC
2081 ACGGTGAGGATTGAATAACCAGGACTTGGGGATATTGTTTGTTGTCAGGGTTATTCTGTGTGGTAAGGAATATTTGTTTC
2161 ACATTTATACATTTTCTTTTTCCACTCACGTAAGTTTCTATCTTGAGAGCATAGTCCAAAGTGCAAAACTTGGTGTTTAC
2241 AAGGAAAATTGTCTTCCAGAACTCCACTGTCATCACTTTCACCAAAGTGGAAGTTTGCATGAATATGCTCAGAATCTAAT
2321 ATTCAATGTTCTGTTACATTGTAAGTGAAGTCCAGCTACAAAATAGATTTAATATATTGAATTTATTTGTACATATGCAG
2401 AGTACGGTATTTCTGTATGGAATCTGCTTTATTCCTATTTTTCCCAACTCTGATGAGTAGAATATTAAATGTGTTGTTAT
2481 GGAAATACAGATTATTGCTTCTATAGGAAGATAATTATGAAAATAAAACCTGAAACTATATAAATATAAAAAAAAAAAAA
2561 AAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cuuaGUG-UUUACAGGAAUUAUc 5'
              :|| ||||   :|||||| 
Target 5' cagcTACAAAATAGATTTAATAt 3'
2353 - 2375 138.00 -5.10
2
miRNA  3' cuUAGUGUUUACAGGAAUUAuc 5'
            | :|:|::| | ||||||  
Target 5' tgAGTATAGGT-TGCTTAATtt 3'
1443 - 1463 135.00 -6.70
3
miRNA  3' cuuaguguuuacAGGAAUUAuc 5'
                      ||||||||  
Target 5' taatgtttttctTCCTTAATtt 3'
1627 - 1648 130.00 -6.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30562953 13 COSMIC
COSN30496327 29 COSMIC
COSN30530682 60 COSMIC
COSN31560556 61 COSMIC
COSN20044254 68 COSMIC
COSN19702458 88 COSMIC
COSN31562230 97 COSMIC
COSN21668479 292 COSMIC
COSN6114021 380 COSMIC
COSN15663261 705 COSMIC
COSN29689002 889 COSMIC
COSN24971026 980 COSMIC
COSN9325129 1577 COSMIC
COSN23456050 1678 COSMIC
COSN30230548 2091 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs749594206 1 dbSNP
rs201815245 5 dbSNP
rs1421695479 17 dbSNP
rs1483728573 24 dbSNP
rs1190508203 30 dbSNP
rs887756893 36 dbSNP
rs1381011395 37 dbSNP
rs773143897 38 dbSNP
rs1477707227 49 dbSNP
rs763888237 50 dbSNP
rs1171927336 51 dbSNP
rs541604744 52 dbSNP
rs1258939571 69 dbSNP
rs1006212998 71 dbSNP
rs1014972621 77 dbSNP
rs1485566375 78 dbSNP
rs1278569561 81 dbSNP
rs1218355006 82 dbSNP
rs1381379633 84 dbSNP
rs962280682 87 dbSNP
rs932401718 88 dbSNP
rs1314426967 104 dbSNP
rs1322973197 114 dbSNP
rs1315511765 119 dbSNP
rs368370775 121 dbSNP
rs985252739 124 dbSNP
rs563178587 127 dbSNP
rs1466670239 128 dbSNP
rs1414042401 136 dbSNP
rs192986652 140 dbSNP
rs1035822811 142 dbSNP
rs1299740710 143 dbSNP
rs545626908 148 dbSNP
rs1036939269 150 dbSNP
rs762146177 162 dbSNP
rs1370228702 163 dbSNP
rs533874706 173 dbSNP
rs1475133509 176 dbSNP
rs1255853053 180 dbSNP
rs1196372501 181 dbSNP
rs1488812061 185 dbSNP
rs931330194 187 dbSNP
rs373033183 193 dbSNP
rs895195803 199 dbSNP
rs1265459570 201 dbSNP
rs547243709 204 dbSNP
rs1232611755 206 dbSNP
rs1332676491 223 dbSNP
rs979065969 232 dbSNP
rs1219062619 235 dbSNP
rs1158057850 240 dbSNP
rs1012286953 246 dbSNP
rs372367722 249 dbSNP
rs1412402291 250 dbSNP
rs1392983906 253 dbSNP
rs1048495 260 dbSNP
rs1326583242 272 dbSNP
rs1025073252 273 dbSNP
rs142060068 277 dbSNP
rs1475967346 282 dbSNP
rs1372824619 293 dbSNP
rs1190598124 296 dbSNP
rs1040698517 301 dbSNP
rs999676945 310 dbSNP
rs1253237783 313 dbSNP
rs1212592715 314 dbSNP
rs1031234902 315 dbSNP
rs1199151866 316 dbSNP
rs958571945 318 dbSNP
rs923107166 321 dbSNP
rs931822907 327 dbSNP
rs551185280 330 dbSNP
rs1404807661 333 dbSNP
rs369812118 335 dbSNP
rs989798228 336 dbSNP
rs1050303341 338 dbSNP
rs1304242834 347 dbSNP
rs1333986794 353 dbSNP
rs1410964904 354 dbSNP
rs569516353 357 dbSNP
rs1396235535 358 dbSNP
rs879532292 371 dbSNP
rs17547178 372 dbSNP
rs1390428927 378 dbSNP
rs1006343621 380 dbSNP
rs1036330273 381 dbSNP
rs985221742 391 dbSNP
rs1331646382 393 dbSNP
rs1452066808 404 dbSNP
rs73392661 429 dbSNP
rs1003101556 430 dbSNP
rs566826755 431 dbSNP
rs1270787134 435 dbSNP
rs1312858822 437 dbSNP
rs533962868 441 dbSNP
rs36024433 447 dbSNP
rs1013481542 449 dbSNP
rs1281357924 453 dbSNP
rs1233790202 455 dbSNP
rs1311471449 462 dbSNP
rs555372453 462 dbSNP
rs1443017768 464 dbSNP
rs1335748067 466 dbSNP
rs1416560489 467 dbSNP
rs918500987 480 dbSNP
rs1183141151 491 dbSNP
rs1172654403 494 dbSNP
rs184671071 508 dbSNP
rs758021934 510 dbSNP
rs1177344316 514 dbSNP
rs895154392 525 dbSNP
rs1231153254 534 dbSNP
rs375860232 543 dbSNP
rs1030587473 554 dbSNP
rs1046450582 555 dbSNP
rs1210445769 557 dbSNP
rs1346074487 563 dbSNP
rs1286595144 566 dbSNP
rs906649658 569 dbSNP
rs1428448138 570 dbSNP
rs999645974 571 dbSNP
rs956392537 577 dbSNP
rs1356523136 579 dbSNP
rs1053041062 581 dbSNP
rs1362125717 582 dbSNP
rs894019561 582 dbSNP
rs1352234020 583 dbSNP
rs1405111971 584 dbSNP
rs535401382 584 dbSNP
rs1164953127 594 dbSNP
rs1475460168 599 dbSNP
rs975997882 602 dbSNP
rs556735338 605 dbSNP
rs1308252015 616 dbSNP
rs1185604925 620 dbSNP
rs951678428 626 dbSNP
rs186787170 629 dbSNP
rs1006586451 633 dbSNP
rs931942048 646 dbSNP
rs545849034 648 dbSNP
rs1216724831 649 dbSNP
rs986360687 652 dbSNP
rs1282175529 660 dbSNP
rs1235686252 661 dbSNP
rs79422147 663 dbSNP
rs1293195834 667 dbSNP
rs942052994 668 dbSNP
rs1368866442 671 dbSNP
rs191305808 673 dbSNP
rs965160756 674 dbSNP
rs1342937628 676 dbSNP
rs539830198 677 dbSNP
rs183460375 678 dbSNP
rs1325030528 684 dbSNP
rs1461497492 686 dbSNP
rs1162664189 687 dbSNP
rs1417142397 687 dbSNP
rs1271032874 689 dbSNP
rs972556301 693 dbSNP
rs1036466506 694 dbSNP
rs1475171127 697 dbSNP
rs150720033 708 dbSNP
rs139177320 709 dbSNP
rs9954767 722 dbSNP
rs1468946333 727 dbSNP
rs916529338 729 dbSNP
rs1212320129 736 dbSNP
rs113658668 737 dbSNP
rs948038297 737 dbSNP
rs1296664858 739 dbSNP
rs1057154241 743 dbSNP
rs1359507104 743 dbSNP
rs563029218 745 dbSNP
rs1441058545 751 dbSNP
rs1393047296 752 dbSNP
rs1426501879 753 dbSNP
rs1467070303 753 dbSNP
rs377632744 753 dbSNP
rs532915719 753 dbSNP
rs1417694158 756 dbSNP
rs1195696145 761 dbSNP
rs1478342036 770 dbSNP
rs1490100404 772 dbSNP
rs1252400411 773 dbSNP
rs569996748 773 dbSNP
rs1192320510 775 dbSNP
rs1022179526 777 dbSNP
rs1252394426 778 dbSNP
rs1481866877 778 dbSNP
rs1204327383 780 dbSNP
rs1306096790 783 dbSNP
rs1416849190 784 dbSNP
rs904703597 784 dbSNP
rs1430846407 785 dbSNP
rs1480701234 785 dbSNP
rs535582395 785 dbSNP
rs1000549051 786 dbSNP
rs534914807 786 dbSNP
rs149961165 787 dbSNP
rs1460307397 788 dbSNP
rs865909359 789 dbSNP
rs1371969213 791 dbSNP
rs893981020 791 dbSNP
rs1377002800 796 dbSNP
rs189403072 796 dbSNP
rs1175781413 798 dbSNP
rs769895115 799 dbSNP
rs1435507468 800 dbSNP
rs1405452730 802 dbSNP
rs1171924269 805 dbSNP
rs1423162293 807 dbSNP
rs1251921250 809 dbSNP
rs976136153 809 dbSNP
rs1177095538 819 dbSNP
rs1302969206 821 dbSNP
rs1479876215 825 dbSNP
rs1259982670 832 dbSNP
rs1030037627 840 dbSNP
rs953383816 843 dbSNP
rs1346789081 852 dbSNP
rs1011104743 864 dbSNP
rs1051100440 865 dbSNP
rs78193205 876 dbSNP
rs1306233358 879 dbSNP
rs1389550814 879 dbSNP
rs372659044 880 dbSNP
rs72972844 883 dbSNP
rs1229165053 885 dbSNP
rs941853596 888 dbSNP
rs971918273 889 dbSNP
rs1025445686 890 dbSNP
rs1357504385 890 dbSNP
rs919320821 898 dbSNP
rs1288947266 899 dbSNP
rs1451959636 902 dbSNP
rs562681500 904 dbSNP
rs1223674195 906 dbSNP
rs1240225432 907 dbSNP
rs1420651432 908 dbSNP
rs1189169371 914 dbSNP
rs147607391 916 dbSNP
rs1255007083 917 dbSNP
rs952639270 925 dbSNP
rs1485919854 927 dbSNP
rs1259570180 937 dbSNP
rs1236797600 943 dbSNP
rs567370134 951 dbSNP
rs1188595982 954 dbSNP
rs1391446840 957 dbSNP
rs1442451291 959 dbSNP
rs1232498827 960 dbSNP
rs983993544 965 dbSNP
rs1057440254 977 dbSNP
rs916494660 978 dbSNP
rs1332466123 992 dbSNP
rs1162271130 996 dbSNP
rs1385773376 999 dbSNP
rs894487356 1004 dbSNP
rs1455701816 1016 dbSNP
rs1397387704 1018 dbSNP
rs969311056 1019 dbSNP
rs535318603 1023 dbSNP
rs982039948 1025 dbSNP
rs76533411 1033 dbSNP
rs1345070261 1036 dbSNP
rs1043309952 1045 dbSNP
rs1435950256 1047 dbSNP
rs575367181 1050 dbSNP
rs1322699167 1053 dbSNP
rs904670973 1054 dbSNP
rs1052934450 1059 dbSNP
rs998967658 1063 dbSNP
rs1245599689 1064 dbSNP
rs749301159 1075 dbSNP
rs915351678 1079 dbSNP
rs1227886923 1081 dbSNP
rs1031824142 1084 dbSNP
rs1327310105 1093 dbSNP
rs537439003 1099 dbSNP
rs1433035964 1103 dbSNP
rs1373233453 1108 dbSNP
rs1050648103 1111 dbSNP
rs1461322856 1131 dbSNP
rs889335674 1134 dbSNP
rs1356804008 1135 dbSNP
rs768775251 1138 dbSNP
rs542387345 1141 dbSNP
rs1282100873 1144 dbSNP
rs1186237780 1161 dbSNP
rs944945159 1163 dbSNP
rs1253018378 1170 dbSNP
rs1192938459 1177 dbSNP
rs539235168 1178 dbSNP
rs1275016633 1195 dbSNP
rs900854290 1196 dbSNP
rs993878632 1201 dbSNP
rs1459588623 1202 dbSNP
rs1186408499 1203 dbSNP
rs1025797989 1208 dbSNP
rs888242553 1225 dbSNP
rs181963779 1226 dbSNP
rs953090998 1227 dbSNP
rs1023432907 1229 dbSNP
rs1392375236 1236 dbSNP
rs1007859963 1237 dbSNP
rs774439476 1238 dbSNP
rs1034927978 1245 dbSNP
rs1411652347 1248 dbSNP
rs956901624 1251 dbSNP
rs1476744579 1253 dbSNP
rs142147425 1257 dbSNP
rs915301656 1260 dbSNP
rs1437036738 1267 dbSNP
rs762238401 1276 dbSNP
rs986262458 1277 dbSNP
rs540373927 1280 dbSNP
rs919124736 1282 dbSNP
rs764052146 1295 dbSNP
rs561619955 1298 dbSNP
rs573685076 1305 dbSNP
rs16974852 1307 dbSNP
rs144445471 1320 dbSNP
rs533710263 1321 dbSNP
rs761165015 1332 dbSNP
rs1375736211 1333 dbSNP
rs773519083 1334 dbSNP
rs1277603881 1345 dbSNP
rs1412293020 1345 dbSNP
rs1409466741 1349 dbSNP
rs551668648 1351 dbSNP
rs1349640633 1358 dbSNP
rs147900281 1364 dbSNP
rs1469503803 1370 dbSNP
rs1409651227 1374 dbSNP
rs80001658 1378 dbSNP
rs565892113 1379 dbSNP
rs1053209815 1380 dbSNP
rs766742693 1384 dbSNP
rs15937 1386 dbSNP
rs997650479 1387 dbSNP
rs1286981591 1401 dbSNP
rs1235579628 1402 dbSNP
rs1356462644 1406 dbSNP
rs1051535351 1407 dbSNP
rs1346457448 1408 dbSNP
rs1179200934 1411 dbSNP
rs888891537 1412 dbSNP
rs1034895377 1413 dbSNP
rs1399601471 1415 dbSNP
rs1386420955 1417 dbSNP
rs1007211378 1418 dbSNP
rs1166969971 1426 dbSNP
rs1475430721 1430 dbSNP
rs956681343 1434 dbSNP
rs1181503380 1437 dbSNP
rs1015975693 1438 dbSNP
rs963281089 1441 dbSNP
rs1244047055 1449 dbSNP
rs1216655283 1452 dbSNP
rs1473082727 1475 dbSNP
rs1022295153 1479 dbSNP
rs1464477066 1487 dbSNP
rs1266820581 1493 dbSNP
rs1216048741 1494 dbSNP
rs993424174 1497 dbSNP
rs1184982927 1504 dbSNP
rs1026115047 1525 dbSNP
rs554687436 1526 dbSNP
rs1270388105 1535 dbSNP
rs1429462162 1546 dbSNP
rs993294684 1549 dbSNP
rs944839560 1551 dbSNP
rs915985050 1552 dbSNP
rs970571409 1553 dbSNP
rs1327869780 1561 dbSNP
rs10207 1566 dbSNP
rs115557966 1567 dbSNP
rs569040293 1569 dbSNP
rs1187294892 1572 dbSNP
rs1307653478 1576 dbSNP
rs1448966137 1585 dbSNP
rs1246200943 1589 dbSNP
rs1369723496 1591 dbSNP
rs1196055142 1592 dbSNP
rs553545187 1592 dbSNP
rs934874524 1596 dbSNP
rs539761409 1598 dbSNP
rs1469357436 1601 dbSNP
rs929583285 1605 dbSNP
rs1047130776 1611 dbSNP
rs1273309377 1611 dbSNP
rs1227147717 1619 dbSNP
rs1343526327 1620 dbSNP
rs1339453588 1626 dbSNP
rs76649141 1629 dbSNP
rs757204285 1630 dbSNP
rs1366886424 1634 dbSNP
rs1274980444 1640 dbSNP
rs1044774129 1642 dbSNP
rs1354854785 1671 dbSNP
rs1193720288 1674 dbSNP
rs375917566 1675 dbSNP
rs573682180 1691 dbSNP
rs1175665059 1697 dbSNP
rs1003321619 1702 dbSNP
rs934161514 1706 dbSNP
rs781247750 1719 dbSNP
rs1056233128 1720 dbSNP
rs1233752731 1721 dbSNP
rs1200182601 1722 dbSNP
rs1481902542 1731 dbSNP
rs1281996529 1732 dbSNP
rs143629997 1742 dbSNP
rs1474430631 1743 dbSNP
rs888866570 1743 dbSNP
rs879196356 1745 dbSNP
rs16974856 1746 dbSNP
rs3790135 1748 dbSNP
rs1430205320 1751 dbSNP
rs966152424 1757 dbSNP
rs749465041 1764 dbSNP
rs976215080 1767 dbSNP
rs1388285186 1770 dbSNP
rs1243308200 1775 dbSNP
rs768867231 1779 dbSNP
rs544208323 1780 dbSNP
rs985046694 1783 dbSNP
rs568362920 1793 dbSNP
rs1386200325 1794 dbSNP
rs113434674 1796 dbSNP
rs148091514 1797 dbSNP
rs112407016 1812 dbSNP
rs1181972634 1813 dbSNP
rs1482261672 1816 dbSNP
rs578181952 1817 dbSNP
rs941026943 1821 dbSNP
rs1342484142 1826 dbSNP
rs1482653206 1829 dbSNP
rs1253679817 1830 dbSNP
rs1230130241 1843 dbSNP
rs774353653 1848 dbSNP
rs73942697 1853 dbSNP
rs1226387455 1855 dbSNP
rs1488357404 1861 dbSNP
rs1295371636 1868 dbSNP
rs939104684 1871 dbSNP
rs772448794 1872 dbSNP
rs1023259904 1882 dbSNP
rs773809714 1884 dbSNP
rs373759565 1889 dbSNP
rs1056674629 1897 dbSNP
rs1445374313 1899 dbSNP
rs1390072408 1900 dbSNP
rs1159026781 1902 dbSNP
rs1471829692 1907 dbSNP
rs1420406991 1908 dbSNP
rs1188229451 1910 dbSNP
rs756969011 1912 dbSNP
rs1422944692 1917 dbSNP
rs1253623361 1923 dbSNP
rs780826500 1926 dbSNP
rs892314650 1931 dbSNP
rs185417558 1937 dbSNP
rs1032950419 1938 dbSNP
rs956052309 1939 dbSNP
rs988800939 1943 dbSNP
rs903810177 1950 dbSNP
rs1007559501 1953 dbSNP
rs1017626126 1954 dbSNP
rs1310810947 1961 dbSNP
rs966080070 1964 dbSNP
rs34934801 1966 dbSNP
rs922860658 1966 dbSNP
rs542668130 1971 dbSNP
rs1456054048 1978 dbSNP
rs934273534 1979 dbSNP
rs1164253733 1985 dbSNP
rs79844355 1987 dbSNP
rs985637528 1988 dbSNP
rs766716525 1997 dbSNP
rs943062745 2001 dbSNP
rs527890314 2006 dbSNP
rs367945517 2016 dbSNP
rs1037474913 2017 dbSNP
rs1469820185 2020 dbSNP
rs898806826 2033 dbSNP
rs1209064627 2043 dbSNP
rs1310054684 2055 dbSNP
rs926307432 2064 dbSNP
rs1321512672 2067 dbSNP
rs1263925869 2072 dbSNP
rs1229816219 2073 dbSNP
rs145151974 2081 dbSNP
rs928945610 2083 dbSNP
rs776888817 2084 dbSNP
rs1373885479 2086 dbSNP
rs913666465 2087 dbSNP
rs945229143 2089 dbSNP
rs1349216666 2092 dbSNP
rs762629393 2102 dbSNP
rs1388962219 2113 dbSNP
rs895731602 2122 dbSNP
rs1429918975 2123 dbSNP
rs1043987456 2124 dbSNP
rs903739004 2128 dbSNP
rs561023976 2135 dbSNP
rs1014622601 2141 dbSNP
rs1287161216 2151 dbSNP
rs1039030055 2154 dbSNP
rs1378166303 2157 dbSNP
rs1248789714 2165 dbSNP
rs745591948 2172 dbSNP
rs1198025565 2177 dbSNP
rs901830923 2185 dbSNP
rs1466309104 2186 dbSNP
rs997948377 2188 dbSNP
rs1274158425 2189 dbSNP
rs1483540748 2189 dbSNP
rs566537526 2190 dbSNP
rs905722074 2191 dbSNP
rs1233087846 2192 dbSNP
rs1329714414 2199 dbSNP
rs1016845384 2201 dbSNP
rs1410813621 2202 dbSNP
rs1369604800 2208 dbSNP
rs1305756338 2209 dbSNP
rs1436071697 2212 dbSNP
rs1255670583 2220 dbSNP
rs1423056414 2225 dbSNP
rs970257733 2226 dbSNP
rs1365446962 2227 dbSNP
rs1369955559 2251 dbSNP
rs1472126622 2254 dbSNP
rs9317 2256 dbSNP
rs1203228699 2257 dbSNP
rs1033044024 2273 dbSNP
rs1444215216 2277 dbSNP
rs1279342277 2287 dbSNP
rs1199939115 2290 dbSNP
rs1343564082 2299 dbSNP
rs189899741 2300 dbSNP
rs1388739562 2301 dbSNP
rs1229430817 2302 dbSNP
rs533029974 2308 dbSNP
rs1458307964 2316 dbSNP
rs1300740446 2327 dbSNP
rs1416170511 2339 dbSNP
rs1030107564 2341 dbSNP
rs1332990356 2356 dbSNP
rs992275980 2359 dbSNP
rs955615138 2362 dbSNP
rs1159767614 2363 dbSNP
rs986116834 2369 dbSNP
rs1180299347 2373 dbSNP
rs1315339634 2380 dbSNP
rs368193699 2381 dbSNP
rs911372384 2385 dbSNP
rs1238257419 2390 dbSNP
rs551658913 2394 dbSNP
rs6505570 2406 dbSNP
rs376651356 2407 dbSNP
rs767330266 2414 dbSNP
rs1228395052 2415 dbSNP
rs539340927 2416 dbSNP
rs1379499797 2417 dbSNP
rs533997006 2418 dbSNP
rs1283212050 2423 dbSNP
rs895480950 2425 dbSNP
rs756030230 2427 dbSNP
rs1321158752 2428 dbSNP
rs1255453927 2436 dbSNP
rs1483729208 2438 dbSNP
rs555630688 2439 dbSNP
rs14587 2447 dbSNP
rs1422919610 2448 dbSNP
rs1166906622 2449 dbSNP
rs905815386 2463 dbSNP
rs901799723 2466 dbSNP
rs779862080 2472 dbSNP
rs1258086659 2473 dbSNP
rs558938773 2474 dbSNP
rs570312058 2479 dbSNP
rs1181385614 2480 dbSNP
rs1412562169 2481 dbSNP
rs933327036 2485 dbSNP
rs1464886178 2487 dbSNP
rs999967713 2488 dbSNP
rs1173393195 2489 dbSNP
rs538139318 2499 dbSNP
rs1054256317 2504 dbSNP
rs1322660075 2506 dbSNP
rs1466288486 2507 dbSNP
rs1288735517 2521 dbSNP
rs1048199336 2533 dbSNP
rs1343688949 2536 dbSNP
rs1297780336 2542 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545212. RNA binding protein: AGO1. Condition:Control PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control PAR-CLIP data was present in GSM545215. RNA binding protein: AGO4. Condition:Control PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293
Disease 8774.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "HITS-CLIP data was present in GSM714642. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 8774.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
Experimental Support 4 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 8774.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine "PAR-CLIP data was present in GSM1065668. RNA binding protein: AGO1. Condition:4-thiouridine "PAR-CLIP data was present in GSM1065669. RNA binding protein: AGO1. Condition:4-thiouridine "PAR-CLIP data was present in GSM1065670. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
Experimental Support 5 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 6 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated ...

- Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology.

Article - Farazi TA; Ten Hoeve JJ; Brown M; et al.
- Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
CLIP-seq Support 1 for dataset GSM714642
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000322897.6 | 3UTR | UUUCAUUUAAUAAUUGCUGCUAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545212
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / Control
Location of target site ENST00000322897.6 | 3UTR | UUUCAUUUAAUAAUUGCUGCUAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM545214
Method / RBP PAR-CLIP / AGO3
Cell line / Condition HEK293 / Control
Location of target site ENST00000322897.6 | 3UTR | UUUCAUUUAAUAAUUGCUGCUAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM545215
Method / RBP PAR-CLIP / AGO4
Cell line / Condition HEK293 / Control
Location of target site ENST00000322897.6 | 3UTR | UUUCAUUUAAUAAUUGCUGCUAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000322897.6 | 3UTR | UUUCAUUUAAUAAUUGCUGCUAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM545217
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-7 transfection
Location of target site ENST00000322897.6 | 3UTR | UUUCAUUUAAUAAUUGCUGCUAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000322897.6 | 3UTR | GUUUCAUUUAAUAAUUGCUGCUAAAGGUGAUGUUUACUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000322897.6 | 3UTR | UUUCAUUUAAUAAUUGCUGCUAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000322897.6 | 3UTR | UUUCAUUUAAUAAUUGCUGCUAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
CLIP-seq Support 10 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000322897.6 | 3UTR | UUUCAUUUAAUAAUUGCUGCUAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 11 for dataset GSM1065668
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_7
Location of target site ENST00000322897.6 | 3UTR | UUCAUUUAAUAAUUGCUGCUAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 12 for dataset GSM1065669
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_8
Location of target site ENST00000322897.6 | 3UTR | UUUCAUUUAAUAAUUGCUGCUAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 13 for dataset GSM1065670
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / 4-thiouridine, 3_ML_LG
Location of target site ENST00000322897.6 | 3UTR | UUUCAUUUAAUAAUUGCUGCUAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 14 for dataset SRR1045082
Method / RBP PAR-CLIP / AGO2
Cell line / Condition MCF7 / Untreated
Location of target site ENST00000322897.6 | 3UTR | UUUCAUUUAAUAAUUGCUGCUAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24398324 / SRX388831
CLIP-seq Viewer Link
CLIP-seq Support 15 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000322897.6 | 3UTR | UUUCAUUUAAUAAUUGCUGCUAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
134 hsa-miR-4477a Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055843 PLEKHA1 pleckstrin homology domain containing A1 2 10
MIRT061259 AMOTL1 angiomotin like 1 2 4
MIRT071895 BTF3L4 basic transcription factor 3 like 4 2 6
MIRT076933 MLLT6 MLLT6, PHD finger containing 2 2
MIRT078652 ICT1 mitochondrial ribosomal protein L58 2 2
MIRT083633 PRNP prion protein 2 2
MIRT091629 RPL15 ribosomal protein L15 2 4
MIRT107076 PPP6C protein phosphatase 6 catalytic subunit 2 2
MIRT111191 TRIM33 tripartite motif containing 33 2 2
MIRT114515 ARF6 ADP ribosylation factor 6 2 2
MIRT175250 PSAT1 phosphoserine aminotransferase 1 2 4
MIRT175430 ACSL4 acyl-CoA synthetase long chain family member 4 2 2
MIRT178687 FAM102B family with sequence similarity 102 member B 2 2
MIRT189771 CDADC1 cytidine and dCMP deaminase domain containing 1 2 2
MIRT229450 RPL10 ribosomal protein L10 2 2
MIRT244899 PHF6 PHD finger protein 6 2 2
MIRT249189 AKIRIN1 akirin 1 2 8
MIRT261134 TRIM8 tripartite motif containing 8 2 2
MIRT275561 ZIC5 Zic family member 5 2 4
MIRT275652 ABHD13 abhydrolase domain containing 13 2 2
MIRT288082 UTP18 UTP18, small subunit processome component 2 2
MIRT303605 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 2
MIRT307924 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT316787 FOXC1 forkhead box C1 2 2
MIRT326910 SCML2 Scm polycomb group protein like 2 2 2
MIRT327713 SPIN4 spindlin family member 4 2 2
MIRT331632 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT342506 TMOD3 tropomodulin 3 2 4
MIRT354470 LRRC58 leucine rich repeat containing 58 2 2
MIRT378711 TRIM24 tripartite motif containing 24 2 2
MIRT407462 YDJC YdjC chitooligosaccharide deacetylase homolog 2 2
MIRT408226 SMAD5 SMAD family member 5 2 4
MIRT441824 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT442783 CHD8 chromodomain helicase DNA binding protein 8 2 2
MIRT443184 NHS NHS actin remodeling regulator 2 4
MIRT447615 CUL3 cullin 3 2 2
MIRT450156 DSEL dermatan sulfate epimerase-like 2 2
MIRT454801 NEDD9 neural precursor cell expressed, developmentally down-regulated 9 2 2
MIRT463050 ZNF644 zinc finger protein 644 2 2
MIRT467400 SOCS3 suppressor of cytokine signaling 3 2 2
MIRT468174 SGMS1 sphingomyelin synthase 1 2 2
MIRT468949 RPS14 ribosomal protein S14 2 6
MIRT469835 R3HDM4 R3H domain containing 4 2 2
MIRT470724 POFUT1 protein O-fucosyltransferase 1 2 2
MIRT470902 PLIN3 perilipin 3 2 2
MIRT472467 NAPG NSF attachment protein gamma 2 12
MIRT472602 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT492350 SEMA7A semaphorin 7A (John Milton Hagen blood group) 2 2
MIRT493840 FOXN3 forkhead box N3 2 4
MIRT496318 DOCK9 dedicator of cytokinesis 9 2 2
MIRT500159 CLEC2D C-type lectin domain family 2 member D 2 8
MIRT500535 XPO4 exportin 4 2 4
MIRT503916 FBXL13 F-box and leucine rich repeat protein 13 2 4
MIRT504003 SAT1 spermidine/spermine N1-acetyltransferase 1 2 4
MIRT505647 SHMT1 serine hydroxymethyltransferase 1 2 4
MIRT506574 MIER3 MIER family member 3 2 4
MIRT506945 HS3ST3B1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 2 4
MIRT508196 RPS19 ribosomal protein S19 2 6
MIRT511417 HSPA13 heat shock protein family A (Hsp70) member 13 2 4
MIRT512326 ACTB actin beta 2 4
MIRT515376 RPL7 ribosomal protein L7 2 2
MIRT520422 TUBG1 tubulin gamma 1 2 4
MIRT524844 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT526320 UGT2A1 UDP glucuronosyltransferase family 2 member A1 complex locus 2 2
MIRT526561 UGT2A2 UDP glucuronosyltransferase family 2 member A2 2 2
MIRT528027 FEZ2 fasciculation and elongation protein zeta 2 2 2
MIRT529874 RBM43 RNA binding motif protein 43 2 2
MIRT530826 CLEC4D C-type lectin domain family 4 member D 2 2
MIRT531334 GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 2 2
MIRT532068 CCNB1 cyclin B1 2 4
MIRT532870 ZNF566 zinc finger protein 566 2 2
MIRT535580 NUP35 nucleoporin 35 2 2
MIRT537644 ERGIC2 ERGIC and golgi 2 2 4
MIRT537725 ELAVL2 ELAV like RNA binding protein 2 2 2
MIRT538894 BRI3BP BRI3 binding protein 2 2
MIRT538945 BMP2K BMP2 inducible kinase 2 2
MIRT540703 PDPK1 3-phosphoinositide dependent protein kinase 1 2 4
MIRT543210 TMEM117 transmembrane protein 117 2 3
MIRT543357 LYRM2 LYR motif containing 2 2 2
MIRT544905 CLSPN claspin 2 2
MIRT545532 ARF3 ADP ribosylation factor 3 2 2
MIRT546446 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT546882 PURB purine rich element binding protein B 2 4
MIRT547440 MED13 mediator complex subunit 13 2 2
MIRT548027 GOLIM4 golgi integral membrane protein 4 2 2
MIRT548673 CRNKL1 crooked neck pre-mRNA splicing factor 1 2 2
MIRT550435 LLGL2 LLGL2, scribble cell polarity complex component 2 2
MIRT551850 RPS3 ribosomal protein S3 2 2
MIRT556072 MRFAP1 Morf4 family associated protein 1 2 2
MIRT556554 LIMS1 LIM zinc finger domain containing 1 2 2
MIRT557132 HOXA13 homeobox A13 2 2
MIRT557875 FEM1B fem-1 homolog B 2 4
MIRT558146 ELK4 ELK4, ETS transcription factor 2 2
MIRT558862 CD2AP CD2 associated protein 2 2
MIRT558884 CCNE1 cyclin E1 2 4
MIRT558907 CBX5 chromobox 5 2 2
MIRT559175 BRAP BRCA1 associated protein 2 2
MIRT560860 GAL3ST3 galactose-3-O-sulfotransferase 3 2 2
MIRT561729 PPIF peptidylprolyl isomerase F 2 2
MIRT564024 CEBPB CCAAT/enhancer binding protein beta 2 2
MIRT564366 TRMT5 tRNA methyltransferase 5 2 2
MIRT564609 ZNF703 zinc finger protein 703 2 2
MIRT565494 AZF1 azoospermia factor 1 2 2
MIRT565577 SLC6A8 solute carrier family 6 member 8 2 2
MIRT566947 LEPROT leptin receptor overlapping transcript 2 2
MIRT567293 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT567308 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT568048 CHSY1 chondroitin sulfate synthase 1 2 2
MIRT571807 PHF19 PHD finger protein 19 2 2
MIRT609234 RBM23 RNA binding motif protein 23 2 2
MIRT610328 SSX5 SSX family member 5 2 2
MIRT611428 UGT8 UDP glycosyltransferase 8 2 4
MIRT611709 SLFN13 schlafen family member 13 2 2
MIRT612069 CEP135 centrosomal protein 135 2 4
MIRT617676 JRKL JRK like 2 2
MIRT623684 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT635634 PRR15L proline rich 15 like 2 2
MIRT636422 MBOAT2 membrane bound O-acyltransferase domain containing 2 2 2
MIRT637011 GPATCH11 G-patch domain containing 11 2 2
MIRT644150 C4orf3 chromosome 4 open reading frame 3 2 2
MIRT648562 MEMO1 mediator of cell motility 1 2 2
MIRT650752 WNT16 Wnt family member 16 2 2
MIRT651914 UEVLD UEV and lactate/malate dehyrogenase domains 2 2
MIRT653556 SLC38A7 solute carrier family 38 member 7 2 2
MIRT692277 XRN2 5'-3' exoribonuclease 2 2 2
MIRT697650 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT703876 ERCC6 ERCC excision repair 6, chromatin remodeling factor 2 2
MIRT704615 CLIP1 CAP-Gly domain containing linker protein 1 2 2
MIRT708562 BBOX1 gamma-butyrobetaine hydroxylase 1 2 2
MIRT709614 KBTBD6 kelch repeat and BTB domain containing 6 2 2
MIRT712955 SGCD sarcoglycan delta 2 2
MIRT713502 DCAF17 DDB1 and CUL4 associated factor 17 2 2
MIRT720239 GPBP1 GC-rich promoter binding protein 1 2 2
MIRT724255 GLUD1 glutamate dehydrogenase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4477a Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-4477a Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-4477a Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)

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