miRTarBase - #MIRT472562


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pre-miRNA Information
pre-miRNA hsa-mir-216a   
Genomic Coordinates chr2: 55988950 - 55989059
Description Homo sapiens miR-216a stem-loop
Comment This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-216a-5p
Sequence 19| UAAUCUCAGCUGGCAACUGUGA |40
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 15 2 - 55989027 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs757094946 2 dbSNP
rs746980700 8 dbSNP
rs1249388997 12 dbSNP
rs1188616124 15 dbSNP
rs1490501989 19 dbSNP
rs1465789697 20 dbSNP
rs370221981 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
BA0G4V miR-216a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Tissue .
BA0G4V miR-216a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma MiRNA qPCR analyses
Gene Information
Gene Symbol NACC1   
Synonyms BEND8, BTBD14B, BTBD30, NAC-1, NAC1, NECFM
Description nucleus accumbens associated 1
Transcript NM_052876   
Expression
Putative miRNA Targets on NACC1
3'UTR of NACC1
(miRNA target sites are highlighted)		 
>NACC1|NM_052876|3'UTR
   1 CCCGCCCAGCCTCCCGCGGGGCCACACACTTCCCCTCCCAACACACACACACACCTGCCATCTTGGTCATGAGCTACTGT
  81 CTGTCCCTCCCCAGGACCCGCGGTGGGTGCTGCATGTTCCCGGCCCTCTGCCCCTCCTGTCCTACCCCCTTTCCCCACCG
 161 AGAGCTGGGCCGGGAGAGGACCGCAGGGCAGGTGGCGTGAGGTCCGTGTTGCCTTCTTTAACACACACTCGTGCAGTGGG
 241 GGAGTTCTGGCTCCCCAACCTAACCCCTAGCCGTCATCTCCACACTCACCAGGCCCACCAGGGGAGGGGGCTGGCCTGGG
 321 GGTCTTGGGAAGGCCCCTCCCCAGGCCCTAGGCCACCTCGCGGAAGCCTTCAGCCTCCGCCCCTCACTGCAGCCCCTTGG
 401 GACTTGAGGGGGGCCCCAGGGGTTCTCAGGACCCCTCCCACCACCTCCCAGTGCTTCCACGTCTCCAAAAGCGCCTTCCT
 481 GTCACCCTCGTCTATCCCTGCGCCTGGGGGCTGGGGTAGGCGAGGCCGTGGGGACTACCCATTTTATAGCTGGGGAAACA
 561 GGCTCCGAGAAATTGCACAACCGACCTCAGGTGGCCGGCAGTGGCGTGCCTGGTGCCCTTTCTCCTCTTCCGCCTCTGTT
 641 GCTCCCTTTGGTCCTCTGGGGCCTCAGAGAGGCAGGTCCTAAAGGAGGGGGGGTCTCCTGGGGGCAGACCGAGGGTCTCG
 721 GAGGATAGAATGAGAGGTTTCCAGGGCTGGCAGAGTGTGTGCGTGTGTGTGTGCAGAAGTTTTGCTTTCAAACAAATGAA
 801 GATACAAGAGGCAGTAGGACCTGGGTTGGAACCCAGGGGAGCAGACTGGGGGGCTGTTGCCCCTCCCTCCATCTCCCCAC
 881 ACCCACCCCACCCCACAGCAGGGCTCCTGGCCCCCACCCCCCTGTACATAATTTTTAAAACCTTTTTTTAGCGAATGAAA
 961 TATTGAAGTATAAGATTCCTTTTATTTTTCAAACCAATGGGGCTGTGTCTATTGTCCCCCTCGGTCCCCAGGGGTGGGGG
1041 GCCTTGGAAGGCAGGGCGGTGTTGGGGGGCTGGGGGGCAGGCTGAATGTGTGTGTGTGGGTGTGTATGTGTGGAGTGTGT
1121 GTGTGTGTTTCCATGGTAGGACTCCAGTCCCAGCTGCTGCCTAGGCTCCTGTGGGTCCTGTGGGTCCCCCTCCCCTGTTC
1201 ACCTTCCCCAACAGGGCTATAGTTTAAGGGTGTCCCAGGCCTTGGCTGGTTGGCTGGGCCCAGCTCCTGGGGGCTGGGCA
1281 GGGCAGGGCAGGGCCGGGTCCACTTCCATTGTTAGCAGTTGTTTGCAGAATTTTCTCTTTTACCATTCCTCTCTTTTTGT
1361 TCTCGCCCAGAGTGGGTGGTTTTTTGTTGTTGTTTTAGATTTTCATGTGAAGGCAGTTTTTTTTCTTTTTTAACTCCCCA
1441 TCCCCCTATGCAGGGTGTCATTTCACCATCCACATCCACATCCTTGTTTGTGTTTCTGGCCCTCGTCCTCCCTGCCTCTC
1521 ATCTGCCTCCCCAACCCCCACCTACCCACTGCTCCCAGGGGTCTCTCCAGGGGCAGGGGGATTTTAGGAGATGGGGTGGG
1601 GGCCAGCCCCTACTGGACCCTTGTAATCTGATTTGGAGACCATCCCCCCGATGGGACCAGCAGCCCCGCCGGCCCACTGG
1681 GGGTCCCTCTTAACATCTGCTTGTTGCGGGGGTCAGTCATGAGTGCCAGGGTCTGGCTGGGGTCTTGGCACTGTCTTCCT
1761 GGCCGGGGCCTGAAACCTTAGCCCCCAGCCGGCCTGAGTGGGGGATATTGACACCCCCAGCTAAAGCACAAGCACCTTAG
1841 TCACCCCTCCTCTCCCCCCGCCTCCTGGCCTGCCACCCCACCCCAGCGTTTACCCCAAAGCACAATGCCCTGGTCACTTG
1921 GCAAGCGGCTGGGCCTGACGGAGGCCGAGGGGCAGACCGGGGCTCCAGCCAGACCCCTGAAAGGAAGGTGCTCCCCCACT
2001 TCCAGGCCTTAGTTGGGGTGGGGGGGCCAGCTCCTGGGCCTGGGGTCTTCTCACCCCCACCCCCTTGTCCTGGGTAGGCC
2081 CCTGCCTGCCCCTCTCTGCCTTTTCCTCGGGTGTCCCTCCTCGAGCCCCTGTGGCATTGGCTTGGGTGGCAGAGCCCACT
2161 TGTTTCAGGGACCCCAGGAGGTGCCCCCTGGCTCCCAGGACTGTGTGTGGGTCCGGGGGGTGGGGGGGTGGGGAGAAGGG
2241 TCGGGCAGGGGGTGCAGGGGAGGAAACTCCTCACCAGGAGAGCCAAAGACAGGGTTGTGCCTTACCCCAGGAGCCACCCC
2321 TGTACCCCCCTTGCCCTGCCATTCACCCTCCACCCCTACCCCTGGGCGGCCTGCTGCTTTTTCCTTCTCTTCCTCCCCTG
2401 CCCTGAGCTGCATGGTTCCCCCACCCTGGGCAGCCAGGAAGGAATCTGAATGGAGAATCACCAACCACCAGAGAAAAAAG
2481 ACTGTGGGGCCCTCCCCTGCCAACTCCCCTTCCCTGGCCGCCCACTCAACCCACACCTCTTTCACGCAGGACAGGCTGCC
2561 CACCCTGTCCACGTGAAGTGCCAACGCCCTCCCCACCCTGGGCCGAGCCCCCACCCCTCCCTGGGCCCCCAAGTGAGATT
2641 GCACATTTAACTACTGTAAGGAGAGGAGCGGCGTTGGCAAATGTGAACCATGAGAATATCAGTGATACTGATGAGAATAA
2721 ACTAAACGCCTTTGTAACAGCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agugucaacGGUCGACUCUAAu 5'
                   |||  ||||||| 
Target 5' cctgggcccCCAAGTGAGATTg 3'
 2620 - 2641 149.00 -11.70
2 
miRNA  3' aguguCAACGGUCGACUCUAAu 5'
               ||||::: :| ||||| 
Target 5' tttttGTTGTTGTTTTAGATTt 3'
 1381 - 1402 129.00 -7.50
3 
miRNA  3' agUGUCAACGGUCGACUCUAau 5'
            :||| || |:  ||||:|  
Target 5' ggGCAGGTGGCG--TGAGGTcc 3'
 186 - 205 120.00 -11.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31501468 14 COSMIC
COSN30509781 16 COSMIC
COSN19655250 25 COSMIC
COSN31508431 37 COSMIC
COSN20122097 54 COSMIC
COSN28885404 68 COSMIC
COSN28865097 95 COSMIC
COSN31491592 98 COSMIC
COSN9348072 243 COSMIC
COSN23498407 473 COSMIC
COSN6667008 702 COSMIC
COSN17215173 953 COSMIC
COSN5434826 977 COSMIC
COSN1211077 1400 COSMIC
COSN20949833 1442 COSMIC
COSN28310762 1595 COSMIC
COSN31513279 1651 COSMIC
COSN30542339 1797 COSMIC
COSN14660343 1881 COSMIC
COSN1211079 1986 COSMIC
COSN30157936 2111 COSMIC
COSN26555466 2283 COSMIC
COSN31553581 2307 COSMIC
COSN31483669 2474 COSMIC
COSN9348073 2527 COSMIC
COSN30173245 2532 COSMIC
COSN21501600 2574 COSMIC
COSN31570049 2669 COSMIC
COSN31520892 2733 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs573418276 3 dbSNP
rs45554531 4 dbSNP
rs375584762 5 dbSNP
rs776385727 6 dbSNP
rs759549048 7 dbSNP
rs765164702 8 dbSNP
rs752840729 12 dbSNP
rs779664401 13 dbSNP
rs758612437 14 dbSNP
rs764409556 15 dbSNP
rs751873699 16 dbSNP
rs757536262 17 dbSNP
rs750852747 18 dbSNP
rs370140588 19 dbSNP
rs1181051421 23 dbSNP
rs747641260 24 dbSNP
rs8112067 25 dbSNP
rs1177181339 28 dbSNP
rs971185557 29 dbSNP
rs985240531 30 dbSNP
rs749296750 31 dbSNP
rs1464172231 35 dbSNP
rs1335513515 36 dbSNP
rs1392691805 37 dbSNP
rs141874584 41 dbSNP
rs774555952 41 dbSNP
rs777372603 41 dbSNP
rs746698138 42 dbSNP
rs1448958538 45 dbSNP
rs924540359 46 dbSNP
rs770591351 47 dbSNP
rs776491663 49 dbSNP
rs1303047474 50 dbSNP
rs759334903 52 dbSNP
rs1201990234 53 dbSNP
rs1258270807 54 dbSNP
rs781732659 56 dbSNP
rs769693821 61 dbSNP
rs544190177 63 dbSNP
rs910213290 68 dbSNP
rs562548002 71 dbSNP
rs533076688 78 dbSNP
rs1342774668 79 dbSNP
rs962156752 80 dbSNP
rs991980871 82 dbSNP
rs1234047237 93 dbSNP
rs551679961 100 dbSNP
rs552117276 101 dbSNP
rs922993748 102 dbSNP
rs1242634318 103 dbSNP
rs756736698 110 dbSNP
rs1473118430 115 dbSNP
rs1239109317 117 dbSNP
rs1185194770 122 dbSNP
rs779383508 123 dbSNP
rs1238508967 129 dbSNP
rs1359027412 131 dbSNP
rs748863106 133 dbSNP
rs936355265 134 dbSNP
rs1490292913 149 dbSNP
rs1244640230 157 dbSNP
rs1282909060 157 dbSNP
rs527447519 159 dbSNP
rs548786264 160 dbSNP
rs1052593055 161 dbSNP
rs892229620 166 dbSNP
rs768130136 172 dbSNP
rs1407124651 173 dbSNP
rs1411673279 179 dbSNP
rs568168864 183 dbSNP
rs1040588981 184 dbSNP
rs902094318 186 dbSNP
rs535563037 188 dbSNP
rs1380690080 197 dbSNP
rs550689845 198 dbSNP
rs894463059 205 dbSNP
rs1013440673 207 dbSNP
rs1221708450 209 dbSNP
rs1452862402 212 dbSNP
rs1287061133 216 dbSNP
rs1209777047 217 dbSNP
rs1355050331 223 dbSNP
rs1311999242 224 dbSNP
rs569281858 226 dbSNP
rs952117704 227 dbSNP
rs565548926 230 dbSNP
rs747859479 231 dbSNP
rs148676358 232 dbSNP
rs957552002 236 dbSNP
rs1322893808 248 dbSNP
rs990072853 250 dbSNP
rs962174752 255 dbSNP
rs1390797447 256 dbSNP
rs1160283743 258 dbSNP
rs964428741 259 dbSNP
rs1379409265 263 dbSNP
rs1191428085 265 dbSNP
rs975719176 272 dbSNP
rs534659194 273 dbSNP
rs558395451 274 dbSNP
rs1488931627 276 dbSNP
rs1310272551 278 dbSNP
rs1359078886 286 dbSNP
rs1353469467 290 dbSNP
rs982985356 300 dbSNP
rs1274398291 306 dbSNP
rs1365748818 306 dbSNP
rs773037078 321 dbSNP
rs1267657072 322 dbSNP
rs941635875 328 dbSNP
rs1038599801 331 dbSNP
rs573481394 336 dbSNP
rs1417729249 338 dbSNP
rs1024796354 339 dbSNP
rs1195768084 340 dbSNP
rs969198863 347 dbSNP
rs760553716 348 dbSNP
rs367773693 350 dbSNP
rs1045670227 359 dbSNP
rs1171527921 359 dbSNP
rs980614837 360 dbSNP
rs925244345 361 dbSNP
rs998889284 362 dbSNP
rs936308518 363 dbSNP
rs1238476977 368 dbSNP
rs1212664045 370 dbSNP
rs1310711669 372 dbSNP
rs1278145312 379 dbSNP
rs1219435356 380 dbSNP
rs1320121326 384 dbSNP
rs1276318529 387 dbSNP
rs1242139399 395 dbSNP
rs892954853 398 dbSNP
rs1011803578 406 dbSNP
rs1017537510 408 dbSNP
rs1357177181 408 dbSNP
rs964950423 413 dbSNP
rs1465770092 416 dbSNP
rs534345328 420 dbSNP
rs975746737 424 dbSNP
rs1477811882 428 dbSNP
rs987855279 435 dbSNP
rs1184004320 436 dbSNP
rs1482499043 439 dbSNP
rs1398120747 450 dbSNP
rs556008204 460 dbSNP
rs950479704 461 dbSNP
rs983185018 461 dbSNP
rs1256303908 462 dbSNP
rs1218068660 464 dbSNP
rs913625295 472 dbSNP
rs943808865 474 dbSNP
rs1040557353 482 dbSNP
rs901977967 488 dbSNP
rs181417149 490 dbSNP
rs1447147025 491 dbSNP
rs1332195639 492 dbSNP
rs1382282148 496 dbSNP
rs1051088295 497 dbSNP
rs1328741146 501 dbSNP
rs888063667 502 dbSNP
rs1006615771 503 dbSNP
rs974618037 505 dbSNP
rs1227270161 506 dbSNP
rs1385009458 507 dbSNP
rs1014963835 510 dbSNP
rs1179641304 517 dbSNP
rs1441829333 522 dbSNP
rs1236548158 523 dbSNP
rs1203380747 528 dbSNP
rs1250130148 529 dbSNP
rs1488863361 530 dbSNP
rs1260934584 531 dbSNP
rs916168181 535 dbSNP
rs897904071 540 dbSNP
rs1320699120 552 dbSNP
rs766332864 563 dbSNP
rs1198706912 567 dbSNP
rs1262015134 576 dbSNP
rs117347595 581 dbSNP
rs1201855356 583 dbSNP
rs1306670970 584 dbSNP
rs1390410919 587 dbSNP
rs1256532755 590 dbSNP
rs45536538 591 dbSNP
rs1025015342 597 dbSNP
rs969172930 598 dbSNP
rs1045744729 605 dbSNP
rs928627197 606 dbSNP
rs116765480 607 dbSNP
rs1378805709 610 dbSNP
rs577598542 613 dbSNP
rs1433923344 616 dbSNP
rs1269645663 630 dbSNP
rs368671732 630 dbSNP
rs544692521 632 dbSNP
rs568204879 633 dbSNP
rs1405483098 646 dbSNP
rs1290901796 654 dbSNP
rs913603006 663 dbSNP
rs770327788 665 dbSNP
rs1355614421 666 dbSNP
rs1283544344 673 dbSNP
rs1380094237 674 dbSNP
rs1015984353 678 dbSNP
rs1237881944 680 dbSNP
rs943692896 682 dbSNP
rs1464692034 683 dbSNP
rs1331320192 686 dbSNP
rs1299370532 687 dbSNP
rs1302836585 687 dbSNP
rs1344279159 687 dbSNP
rs1402339948 689 dbSNP
rs976460002 692 dbSNP
rs900456910 693 dbSNP
rs997425300 694 dbSNP
rs897249770 695 dbSNP
rs1403277848 697 dbSNP
rs117922601 702 dbSNP
rs932124899 711 dbSNP
rs950344515 712 dbSNP
rs1259477674 713 dbSNP
rs1489191530 713 dbSNP
rs1050638386 714 dbSNP
rs888023210 716 dbSNP
rs942329944 720 dbSNP
rs1257426203 723 dbSNP
rs1037027813 725 dbSNP
rs1322237578 732 dbSNP
rs897788375 738 dbSNP
rs749390751 752 dbSNP
rs1443636431 755 dbSNP
rs1013556457 759 dbSNP
rs1485373782 763 dbSNP
rs527582333 764 dbSNP
rs1404745759 773 dbSNP
rs1024987739 775 dbSNP
rs548726478 776 dbSNP
rs1203139567 777 dbSNP
rs1265118477 787 dbSNP
rs1424433693 795 dbSNP
rs1172900265 796 dbSNP
rs560788989 804 dbSNP
rs1371237812 805 dbSNP
rs1192333537 814 dbSNP
rs1442811474 814 dbSNP
rs1488555165 829 dbSNP
rs1201394996 833 dbSNP
rs1460597245 836 dbSNP
rs1002429978 849 dbSNP
rs1338058572 850 dbSNP
rs1032217207 855 dbSNP
rs970313283 857 dbSNP
rs1198633209 861 dbSNP
rs1428617690 864 dbSNP
rs958188499 871 dbSNP
rs1452272625 872 dbSNP
rs1401284608 881 dbSNP
rs1178404292 882 dbSNP
rs1009453469 884 dbSNP
rs1333492933 886 dbSNP
rs981644015 890 dbSNP
rs1453377269 896 dbSNP
rs529343338 908 dbSNP
rs375303441 912 dbSNP
rs1020885799 914 dbSNP
rs1370047857 919 dbSNP
rs934676862 920 dbSNP
rs965018926 921 dbSNP
rs976443992 922 dbSNP
rs1200093298 923 dbSNP
rs1238371776 923 dbSNP
rs920995544 937 dbSNP
rs1435586683 938 dbSNP
rs1271604836 941 dbSNP
rs1210962847 942 dbSNP
rs1359072014 953 dbSNP
rs551081497 954 dbSNP
rs767971881 964 dbSNP
rs914663022 965 dbSNP
rs1303093844 971 dbSNP
rs1364795057 976 dbSNP
rs186355764 977 dbSNP
rs1335252167 979 dbSNP
rs1220440671 998 dbSNP
rs947453754 1002 dbSNP
rs1392768562 1006 dbSNP
rs1161483049 1009 dbSNP
rs1423800646 1010 dbSNP
rs569269068 1012 dbSNP
rs113160892 1017 dbSNP
rs997458023 1020 dbSNP
rs1051698606 1023 dbSNP
rs886328239 1024 dbSNP
rs1290259405 1036 dbSNP
rs1354168218 1037 dbSNP
rs1222337520 1038 dbSNP
rs765636099 1046 dbSNP
rs1288518269 1049 dbSNP
rs1222351674 1050 dbSNP
rs1004560350 1054 dbSNP
rs1016341994 1055 dbSNP
rs963193837 1058 dbSNP
rs62109926 1059 dbSNP
rs1301238263 1062 dbSNP
rs1404193377 1063 dbSNP
rs1489454714 1063 dbSNP
rs1192966475 1064 dbSNP
rs1398651092 1064 dbSNP
rs1406760530 1065 dbSNP
rs1172695025 1070 dbSNP
rs1023113734 1071 dbSNP
rs1266081226 1072 dbSNP
rs1199334908 1074 dbSNP
rs1488901412 1075 dbSNP
rs970220189 1076 dbSNP
rs1214066287 1077 dbSNP
rs1268193048 1083 dbSNP
rs1446682399 1083 dbSNP
rs1221103618 1087 dbSNP
rs1282645385 1087 dbSNP
rs1290462098 1087 dbSNP
rs1321517502 1087 dbSNP
rs1341038175 1087 dbSNP
rs981548817 1087 dbSNP
rs1418680002 1089 dbSNP
rs1157103396 1091 dbSNP
rs1382493247 1094 dbSNP
rs1334418162 1095 dbSNP
rs1035914638 1100 dbSNP
rs1426679703 1101 dbSNP
rs1175076822 1102 dbSNP
rs1478465222 1105 dbSNP
rs956254631 1107 dbSNP
rs1420697141 1109 dbSNP
rs914547388 1115 dbSNP
rs988865735 1115 dbSNP
rs567131571 1116 dbSNP
rs1212514799 1118 dbSNP
rs947521817 1119 dbSNP
rs386806955 1120 dbSNP
rs8105087 1121 dbSNP
rs1439272110 1122 dbSNP
rs1297675674 1128 dbSNP
rs1212676441 1133 dbSNP
rs1293564640 1143 dbSNP
rs921986405 1152 dbSNP
rs1454301330 1162 dbSNP
rs1051562983 1167 dbSNP
rs555996090 1167 dbSNP
rs933152777 1167 dbSNP
rs1465722330 1170 dbSNP
rs1355720722 1171 dbSNP
rs1168965137 1176 dbSNP
rs1428369113 1189 dbSNP
rs1415059236 1193 dbSNP
rs1183949001 1196 dbSNP
rs567890028 1201 dbSNP
rs1443060724 1208 dbSNP
rs1242725829 1212 dbSNP
rs1179449722 1216 dbSNP
rs1459155531 1220 dbSNP
rs886358008 1221 dbSNP
rs1202437530 1231 dbSNP
rs537524667 1236 dbSNP
rs1290395113 1242 dbSNP
rs1247864001 1251 dbSNP
rs1380259987 1252 dbSNP
rs1037401388 1260 dbSNP
rs898808964 1270 dbSNP
rs1011893171 1276 dbSNP
rs1350950277 1276 dbSNP
rs1165905296 1278 dbSNP
rs1423162605 1291 dbSNP
rs556187539 1291 dbSNP
rs1179501686 1296 dbSNP
rs1377272971 1309 dbSNP
rs906259959 1310 dbSNP
rs1003001084 1311 dbSNP
rs1247252621 1314 dbSNP
rs1224572730 1334 dbSNP
rs1357020367 1336 dbSNP
rs1035815518 1338 dbSNP
rs1240504796 1340 dbSNP
rs1318334967 1349 dbSNP
rs956348216 1349 dbSNP
rs577683607 1352 dbSNP
rs1323396606 1354 dbSNP
rs1390279376 1354 dbSNP
rs1222253153 1355 dbSNP
rs1403568241 1357 dbSNP
rs544940621 1360 dbSNP
rs199609207 1363 dbSNP
rs190705253 1365 dbSNP
rs754501255 1366 dbSNP
rs1158609437 1369 dbSNP
rs1433870030 1381 dbSNP
rs758963769 1384 dbSNP
rs1334811405 1396 dbSNP
rs1489837022 1397 dbSNP
rs1183336251 1406 dbSNP
rs113519524 1408 dbSNP
rs1217037005 1409 dbSNP
rs542559409 1411 dbSNP
rs1407531537 1413 dbSNP
rs398033978 1417 dbSNP
rs546187201 1417 dbSNP
rs71168663 1417 dbSNP
rs1284641244 1420 dbSNP
rs1166131582 1425 dbSNP
rs111732419 1426 dbSNP
rs1222286879 1431 dbSNP
rs180938945 1438 dbSNP
rs987337376 1441 dbSNP
rs1384310644 1442 dbSNP
rs1332864785 1443 dbSNP
rs1377151082 1444 dbSNP
rs1451507448 1450 dbSNP
rs907696576 1453 dbSNP
rs1174347921 1456 dbSNP
rs1282170393 1458 dbSNP
rs55793294 1462 dbSNP
rs1428475255 1463 dbSNP
rs1193757480 1467 dbSNP
rs940642855 1472 dbSNP
rs1228755803 1476 dbSNP
rs1294777273 1479 dbSNP
rs1204250266 1480 dbSNP
rs1461480172 1480 dbSNP
rs1316062305 1484 dbSNP
rs1264513948 1487 dbSNP
rs1317413642 1493 dbSNP
rs1322167129 1494 dbSNP
rs1196803884 1503 dbSNP
rs1279415927 1504 dbSNP
rs1230191958 1505 dbSNP
rs1038042002 1506 dbSNP
rs899054876 1508 dbSNP
rs1396884832 1512 dbSNP
rs1458354205 1517 dbSNP
rs1408540023 1519 dbSNP
rs947721205 1522 dbSNP
rs1469380956 1529 dbSNP
rs1401059372 1530 dbSNP
rs1044675115 1531 dbSNP
rs1463401266 1532 dbSNP
rs531369208 1535 dbSNP
rs1444907660 1536 dbSNP
rs1244630411 1547 dbSNP
rs1473982551 1547 dbSNP
rs1003236735 1549 dbSNP
rs113101585 1554 dbSNP
rs114398418 1556 dbSNP
rs1337998383 1560 dbSNP
rs1251151411 1562 dbSNP
rs1247131980 1564 dbSNP
rs1477154046 1574 dbSNP
rs1172148856 1577 dbSNP
rs1010378839 1579 dbSNP
rs1400428133 1580 dbSNP
rs533277816 1592 dbSNP
rs1394211427 1598 dbSNP
rs970250109 1598 dbSNP
rs1360613821 1600 dbSNP
rs1425092893 1602 dbSNP
rs980233597 1603 dbSNP
rs1161293827 1606 dbSNP
rs1443632364 1612 dbSNP
rs996182150 1619 dbSNP
rs866680726 1627 dbSNP
rs768385697 1632 dbSNP
rs1338296171 1635 dbSNP
rs1033271706 1644 dbSNP
rs1250471354 1645 dbSNP
rs954805174 1646 dbSNP
rs987535481 1647 dbSNP
rs1280121447 1649 dbSNP
rs907929764 1650 dbSNP
rs1440154959 1651 dbSNP
rs1335197899 1653 dbSNP
rs1218803416 1661 dbSNP
rs962200522 1668 dbSNP
rs973229064 1669 dbSNP
rs1276768744 1671 dbSNP
rs920512636 1672 dbSNP
rs1408219946 1673 dbSNP
rs1159895157 1674 dbSNP
rs1468175034 1683 dbSNP
rs1200786268 1690 dbSNP
rs1362652994 1690 dbSNP
rs1444408505 1693 dbSNP
rs1211241138 1695 dbSNP
rs1262963839 1698 dbSNP
rs1487569399 1700 dbSNP
rs1196492358 1702 dbSNP
rs551744277 1708 dbSNP
rs376564921 1709 dbSNP
rs1170363337 1711 dbSNP
rs566919895 1713 dbSNP
rs1350054507 1714 dbSNP
rs1284000418 1715 dbSNP
rs927618302 1719 dbSNP
rs1426813755 1720 dbSNP
rs939125903 1737 dbSNP
rs1281183383 1750 dbSNP
rs796720438 1761 dbSNP
rs369643293 1762 dbSNP
rs573149503 1765 dbSNP
rs549735256 1766 dbSNP
rs1176504343 1767 dbSNP
rs1481729345 1784 dbSNP
rs55820473 1790 dbSNP
rs1010828314 1791 dbSNP
rs1199269070 1793 dbSNP
rs1401706929 1798 dbSNP
rs1475955041 1800 dbSNP
rs1244131846 1801 dbSNP
rs1446628094 1803 dbSNP
rs1263890531 1807 dbSNP
rs375253493 1816 dbSNP
rs567973256 1818 dbSNP
rs1043190942 1827 dbSNP
rs1281318432 1828 dbSNP
rs1218513214 1833 dbSNP
rs1362405016 1855 dbSNP
rs373589911 1860 dbSNP
rs1428283926 1861 dbSNP
rs1363971571 1862 dbSNP
rs1336937313 1863 dbSNP
rs1470683733 1864 dbSNP
rs556481889 1875 dbSNP
rs996417779 1879 dbSNP
rs377559560 1880 dbSNP
rs1029023058 1884 dbSNP
rs541861164 1888 dbSNP
rs954712857 1889 dbSNP
rs1244013858 1896 dbSNP
rs571279006 1897 dbSNP
rs1460049860 1899 dbSNP
rs1262518003 1916 dbSNP
rs1347353286 1918 dbSNP
rs1209417365 1919 dbSNP
rs1008874663 1923 dbSNP
rs1212620889 1925 dbSNP
rs1274915252 1925 dbSNP
rs1341134787 1928 dbSNP
rs1220062112 1940 dbSNP
rs74180202 1941 dbSNP
rs1380021894 1947 dbSNP
rs1351975351 1948 dbSNP
rs1219343610 1949 dbSNP
rs1053382460 1953 dbSNP
rs962115356 1953 dbSNP
rs920435247 1954 dbSNP
rs969303038 1959 dbSNP
rs1196102429 1960 dbSNP
rs980635886 1975 dbSNP
rs927860144 1978 dbSNP
rs148092886 1986 dbSNP
rs71168664 1986 dbSNP
rs1234552486 1987 dbSNP
rs1202284334 1991 dbSNP
rs1341199311 1998 dbSNP
rs1157692209 2000 dbSNP
rs1378180926 2003 dbSNP
rs1247787055 2005 dbSNP
rs1356791318 2015 dbSNP
rs551983995 2020 dbSNP
rs939032501 2020 dbSNP
rs1052072310 2021 dbSNP
rs913643359 2022 dbSNP
rs1305326780 2024 dbSNP
rs1159093399 2026 dbSNP
rs946483800 2027 dbSNP
rs1368084125 2034 dbSNP
rs1160041307 2045 dbSNP
rs1420970102 2052 dbSNP
rs1043650836 2054 dbSNP
rs1180007215 2055 dbSNP
rs904671283 2056 dbSNP
rs1403577838 2062 dbSNP
rs996322474 2067 dbSNP
rs1321622628 2075 dbSNP
rs1224396404 2082 dbSNP
rs1332925599 2086 dbSNP
rs1437381101 2091 dbSNP
rs1264519171 2092 dbSNP
rs1215995847 2095 dbSNP
rs761725677 2109 dbSNP
rs751077123 2110 dbSNP
rs185918989 2111 dbSNP
rs1346672662 2112 dbSNP
rs373418578 2121 dbSNP
rs1356214626 2123 dbSNP
rs1403513831 2124 dbSNP
rs1208604957 2125 dbSNP
rs1008907262 2129 dbSNP
rs1455534690 2132 dbSNP
rs1343567643 2138 dbSNP
rs989174731 2145 dbSNP
rs1014926159 2147 dbSNP
rs1472245053 2148 dbSNP
rs897940869 2148 dbSNP
rs994915610 2149 dbSNP
rs571735618 2150 dbSNP
rs1235967283 2155 dbSNP
rs969210354 2156 dbSNP
rs1486636606 2163 dbSNP
rs1258487189 2166 dbSNP
rs980542803 2167 dbSNP
rs1323572177 2170 dbSNP
rs1034906724 2172 dbSNP
rs1178993941 2176 dbSNP
rs1330952246 2178 dbSNP
rs1367706356 2185 dbSNP
rs1384181125 2202 dbSNP
rs1360092645 2203 dbSNP
rs1456280648 2210 dbSNP
rs1408322977 2215 dbSNP
rs1460473914 2215 dbSNP
rs960572751 2215 dbSNP
rs1376918359 2216 dbSNP
rs988251261 2219 dbSNP
rs1429974362 2221 dbSNP
rs1245849497 2222 dbSNP
rs913560378 2222 dbSNP
rs946482734 2222 dbSNP
rs1183869798 2223 dbSNP
rs1344894018 2224 dbSNP
rs979224054 2224 dbSNP
rs542497975 2229 dbSNP
rs1392885143 2230 dbSNP
rs932147658 2231 dbSNP
rs1330829619 2236 dbSNP
rs554415069 2240 dbSNP
rs1449331860 2255 dbSNP
rs1394270831 2259 dbSNP
rs1401374236 2263 dbSNP
rs1310388011 2264 dbSNP
rs1340264506 2271 dbSNP
rs1168386220 2272 dbSNP
rs879672352 2283 dbSNP
rs1388017682 2290 dbSNP
rs1286467495 2306 dbSNP
rs1167648108 2307 dbSNP
rs1357750891 2308 dbSNP
rs1197437844 2311 dbSNP
rs1244496832 2316 dbSNP
rs575933399 2317 dbSNP
rs944935276 2321 dbSNP
rs1036803399 2325 dbSNP
rs1251893986 2325 dbSNP
rs1255654359 2328 dbSNP
rs897805261 2330 dbSNP
rs1198903265 2334 dbSNP
rs1274369134 2336 dbSNP
rs1255144328 2339 dbSNP
rs1247067182 2340 dbSNP
rs995221255 2342 dbSNP
rs1282540519 2344 dbSNP
rs1244200622 2345 dbSNP
rs1421836314 2347 dbSNP
rs1027750504 2348 dbSNP
rs1393062947 2349 dbSNP
rs1368971064 2355 dbSNP
rs543561512 2358 dbSNP
rs1170018553 2361 dbSNP
rs1421615113 2364 dbSNP
rs1467325731 2367 dbSNP
rs564972225 2368 dbSNP
rs1401852193 2369 dbSNP
rs1184690789 2371 dbSNP
rs1471890759 2371 dbSNP
rs191619905 2375 dbSNP
rs1251614056 2389 dbSNP
rs1223648065 2394 dbSNP
rs1490932185 2396 dbSNP
rs1288020929 2401 dbSNP
rs1209406407 2402 dbSNP
rs1351579279 2403 dbSNP
rs1034813276 2404 dbSNP
rs960645592 2405 dbSNP
rs1336615505 2415 dbSNP
rs1341566511 2418 dbSNP
rs545196770 2420 dbSNP
rs1405350645 2423 dbSNP
rs1275698772 2425 dbSNP
rs1021267461 2426 dbSNP
rs1159774146 2430 dbSNP
rs182901405 2434 dbSNP
rs1411917113 2447 dbSNP
rs1200723120 2450 dbSNP
rs1481631002 2452 dbSNP
rs1245279992 2455 dbSNP
rs967754045 2459 dbSNP
rs1447774449 2465 dbSNP
rs527655837 2470 dbSNP
rs921018712 2474 dbSNP
rs1328511402 2475 dbSNP
rs932388516 2477 dbSNP
rs1223968490 2485 dbSNP
rs1369551515 2489 dbSNP
rs1272848197 2491 dbSNP
rs1435375765 2498 dbSNP
rs1326625566 2501 dbSNP
rs1455210181 2506 dbSNP
rs1387204045 2507 dbSNP
rs986334234 2509 dbSNP
rs879353642 2510 dbSNP
rs912054021 2519 dbSNP
rs1423569383 2520 dbSNP
rs1172326234 2521 dbSNP
rs1475922448 2525 dbSNP
rs1482103371 2528 dbSNP
rs944975134 2531 dbSNP
rs1464500896 2532 dbSNP
rs1256645011 2536 dbSNP
rs1487898947 2537 dbSNP
rs543185093 2539 dbSNP
rs1276295483 2540 dbSNP
rs549422700 2541 dbSNP
rs930667003 2544 dbSNP
rs1049010716 2546 dbSNP
rs1421487718 2553 dbSNP
rs1432357366 2559 dbSNP
rs905324160 2564 dbSNP
rs1336790138 2566 dbSNP
rs1450864377 2567 dbSNP
rs1478840532 2573 dbSNP
rs567914409 2579 dbSNP
rs1334025272 2580 dbSNP
rs1410889444 2581 dbSNP
rs1056256052 2586 dbSNP
rs1377259448 2587 dbSNP
rs1464765460 2590 dbSNP
rs896342262 2593 dbSNP
rs1174633469 2596 dbSNP
rs1376464246 2598 dbSNP
rs1185467195 2602 dbSNP
rs546239507 2605 dbSNP
rs1296895546 2609 dbSNP
rs1020879853 2610 dbSNP
rs1209266520 2615 dbSNP
rs1438189959 2617 dbSNP
rs1343011519 2618 dbSNP
rs968332394 2632 dbSNP
rs531923753 2633 dbSNP
rs1225784328 2636 dbSNP
rs1340980770 2640 dbSNP
rs550341399 2643 dbSNP
rs1382287298 2650 dbSNP
rs750305164 2652 dbSNP
rs1000577631 2656 dbSNP
rs1376267069 2663 dbSNP
rs1302776964 2664 dbSNP
rs563354741 2670 dbSNP
rs1235002186 2671 dbSNP
rs1027986037 2673 dbSNP
rs571795753 2674 dbSNP
rs1256319578 2678 dbSNP
rs1167125811 2679 dbSNP
rs1422149626 2688 dbSNP
rs953806530 2689 dbSNP
rs1470464947 2690 dbSNP
rs1253756207 2692 dbSNP
rs1202798452 2697 dbSNP
rs1482577522 2699 dbSNP
rs953814126 2725 dbSNP
rs986532176 2728 dbSNP
rs1214263995 2731 dbSNP
rs1265228578 2734 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' agugucaacggucgACUCUAAu 5'
                        ||||||| 
Target 5' --------------UGAGAUUg 3'
 		1 - 8
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000292431.4 | 3UTR | UGAGAUUGCACAUUUAACUACUGUAAGGAGAGGAGCG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000292431.4 | 3UTR | CCCCCACCCCUCCCUGGGCCCCCAAGUGAGAUUGCACAUUUAACUACUGUAAGGAGAGGAGCGGCGUUGGCAAAUGUGAACCAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE42095 Differentiated embryonic stem cells -0.459 1.4e-2 -0.736 3.1e-5 23 Click to see details
GSE28260 Renal cortex and medulla -0.588 1.7e-2 -0.507 3.9e-2 13 Click to see details
GSE14794 Lymphoblastoid cells 0.144 8.8e-2 0.125 1.2e-1 90 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.24 1.2e-1 0.074 3.6e-1 25 Click to see details
GSE21687 Ependynoma primary tumors -0.141 1.3e-1 0.114 1.8e-1 64 Click to see details
GSE38226 Liver fibrosis 0.251 1.4e-1 0.351 5.9e-2 21 Click to see details
GSE17306 Multiple myeloma -0.155 1.4e-1 0.359 5.7e-3 49 Click to see details
GSE26953 Aortic valvular endothelial cells -0.213 1.6e-1 -0.231 1.4e-1 24 Click to see details
GSE27834 Pluripotent stem cells 0.22 2.1e-1 0.385 7.0e-2 16 Click to see details
GSE19350 CNS germ cell tumors 0.248 2.2e-1 0.544 3.4e-2 12 Click to see details
GSE32688 Pancreatic cancer -0.121 2.5e-1 -0.002 5.0e-1 32 Click to see details
GSE21849 B cell lymphoma -0.069 3.6e-1 0.099 3.0e-1 29 Click to see details
GSE28544 Breast cancer 0.053 4.0e-1 0.127 2.8e-1 24 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.052 4.1e-1 0.332 7.6e-2 20 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.035 4.3e-1 0.507 4.8e-3 25 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
ESCA -0.989 0.01 -1.000 0.5 4 Click to see details
BRCA -0.386 0.03 -0.412 0.02 25 Click to see details
PRAD 0.205 0.13 0.261 0.08 31 Click to see details
LUSC 0.24 0.15 0.331 0.08 20 Click to see details
HNSC -0.205 0.17 0.083 0.35 23 Click to see details
STAD -0.192 0.21 -0.144 0.27 20 Click to see details
LIHC -0.116 0.22 -0.120 0.22 45 Click to see details
KIRC 0.143 0.23 0.166 0.19 29 Click to see details
KIRP -0.169 0.25 -0.108 0.33 18 Click to see details
BLCA 0.191 0.3 0.067 0.43 10 Click to see details
LUAD 0.195 0.31 -0.067 0.43 9 Click to see details
CHOL 0.202 0.32 0.286 0.25 8 Click to see details
UCEC 0.11 0.38 -0.055 0.44 10 Click to see details
PAAD -0.198 0.4 -0.400 0.3 4 Click to see details
KICH 0.063 0.43 0.127 0.35 11 Click to see details
THCA 0.002 0.49 -0.090 0.27 47 Click to see details
THCA 0.002 0.49 -0.090 0.27 47 Click to see details
THCA 0.002 0.49 -0.090 0.27 47 Click to see details
148 hsa-miR-216a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000534 PTEN phosphatase and tensin homolog 4 3
MIRT005018 SIRT1 sirtuin 1 3 1
MIRT005964 CDC42 cell division cycle 42 2 1
MIRT005969 CD44 CD44 molecule (Indian blood group) 2 1
MIRT007154 SMAD7 SMAD family member 7 1 1
MIRT054887 BECN1 beclin 1 5 3
MIRT067588 METAP2 methionyl aminopeptidase 2 2 6
MIRT099144 MYLIP myosin regulatory light chain interacting protein 2 12
MIRT162313 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT230668 DFFA DNA fragmentation factor subunit alpha 2 2
MIRT256274 PHAX phosphorylated adaptor for RNA export 2 2
MIRT386817 RAD51L3-RFFL RAD51L3-RFFL readthrough 2 2
MIRT386825 RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase 2 2
MIRT438816 HNF4A hepatocyte nuclear factor 4 alpha 1 1
MIRT464699 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT465962 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT466046 TMEM189 transmembrane protein 189 2 2
MIRT466482 TECPR2 tectonin beta-propeller repeat containing 2 2 7
MIRT472209 NGFRAP1 brain expressed X-linked 3 2 4
MIRT472562 NACC1 nucleus accumbens associated 1 2 4
MIRT478921 CPS1 carbamoyl-phosphate synthase 1 2 2
MIRT480121 CALR calreticulin 2 2
MIRT497754 OXGR1 oxoglutarate receptor 1 2 2
MIRT497967 TWISTNB TWIST neighbor 2 2
MIRT502882 CDK4 cyclin dependent kinase 4 2 8
MIRT510191 MON1B MON1 homolog B, secretory trafficking associated 2 4
MIRT512407 CD84 CD84 molecule 2 2
MIRT513739 PSD3 pleckstrin and Sec7 domain containing 3 2 4
MIRT526257 DROSHA drosha ribonuclease III 2 2
MIRT528968 FAM19A3 family with sequence similarity 19 member A3, C-C motif chemokine like 2 2
MIRT529599 C6orf132 chromosome 6 open reading frame 132 2 2
MIRT529776 ZNF486 zinc finger protein 486 2 2
MIRT530110 PSAPL1 prosaposin like 1 (gene/pseudogene) 2 2
MIRT530504 FADS6 fatty acid desaturase 6 2 2
MIRT531437 PAK1 p21 (RAC1) activated kinase 1 2 2
MIRT534445 SDR16C5 short chain dehydrogenase/reductase family 16C member 5 2 2
MIRT537286 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT538451 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT543085 ACTB actin beta 2 2
MIRT550982 ZNF254 zinc finger protein 254 2 2
MIRT556259 MAPRE2 microtubule associated protein RP/EB family member 2 2 2
MIRT556639 LAMC1 laminin subunit gamma 1 2 2
MIRT559127 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT561405 TUBB2A tubulin beta 2A class IIa 2 2
MIRT569677 SEC23B Sec23 homolog B, coat complex II component 2 4
MIRT574660 KLHL15 kelch like family member 15 2 2
MIRT575030 Tecpr2 tectonin beta-propeller repeat containing 2 2 5
MIRT617683 JRKL JRK like 2 2
MIRT618540 SEMA5A semaphorin 5A 2 2
MIRT620805 C1orf27 chromosome 1 open reading frame 27 2 2
MIRT621569 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT622133 SP4 Sp4 transcription factor 2 2
MIRT624913 CTCFL CCCTC-binding factor like 2 2
MIRT625010 PAK4 p21 (RAC1) activated kinase 4 2 2
MIRT626644 ZNF551 zinc finger protein 551 2 2
MIRT626646 ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 2 2
MIRT626672 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT627945 NNT nicotinamide nucleotide transhydrogenase 2 2
MIRT627963 NLK nemo like kinase 2 2
MIRT628767 SRSF7 serine and arginine rich splicing factor 7 2 2
MIRT629261 KDM2B lysine demethylase 2B 2 2
MIRT629422 ADM2 adrenomedullin 2 2 2
MIRT630238 SORD sorbitol dehydrogenase 2 2
MIRT631272 CENPM centromere protein M 2 4
MIRT631793 CLK4 CDC like kinase 4 2 2
MIRT632058 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT632485 RPS15A ribosomal protein S15a 2 2
MIRT632611 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT632708 MTA3 metastasis associated 1 family member 3 2 2
MIRT632815 INO80 INO80 complex subunit 2 2
MIRT635956 PLA2G12A phospholipase A2 group XIIA 2 2
MIRT636152 UBXN2A UBX domain protein 2A 2 2
MIRT636899 C5orf45 MRN complex interacting protein 2 4
MIRT636930 AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 2 2
MIRT637457 ZNF324B zinc finger protein 324B 2 2
MIRT637900 SLC19A3 solute carrier family 19 member 3 2 2
MIRT639826 ZNF638 zinc finger protein 638 2 2
MIRT640445 ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope 2 2
MIRT640681 ARSK arylsulfatase family member K 2 2
MIRT641611 CAPN7 calpain 7 2 2
MIRT641676 AKR7A2 aldo-keto reductase family 7 member A2 2 2
MIRT646786 IL23R interleukin 23 receptor 2 2
MIRT648352 A2ML1 alpha-2-macroglobulin like 1 2 2
MIRT649144 SPATA5 spermatogenesis associated 5 2 2
MIRT649254 TRIM65 tripartite motif containing 65 2 2
MIRT652491 TMEM178B transmembrane protein 178B 2 2
MIRT653308 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT653945 SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase 2 2
MIRT654212 RNF19B ring finger protein 19B 2 2
MIRT654839 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT655159 PHF21A PHD finger protein 21A 2 2
MIRT655316 PDCD11 programmed cell death 11 2 2
MIRT655375 PAX3 paired box 3 2 2
MIRT657301 HOXB5 homeobox B5 2 2
MIRT657593 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2 2
MIRT658460 FAM117B family with sequence similarity 117 member B 2 2
MIRT658716 ELOVL4 ELOVL fatty acid elongase 4 2 2
MIRT661640 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT661712 MTO1 mitochondrial tRNA translation optimization 1 2 4
MIRT661833 ZNF793 zinc finger protein 793 2 2
MIRT663805 BET1L Bet1 golgi vesicular membrane trafficking protein like 2 2
MIRT663884 CXorf56 chromosome X open reading frame 56 2 2
MIRT664672 L2HGDH L-2-hydroxyglutarate dehydrogenase 2 2
MIRT665814 TMEM168 transmembrane protein 168 2 2
MIRT668159 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT668430 FAM20B FAM20B, glycosaminoglycan xylosylkinase 2 2
MIRT672306 GP2 glycoprotein 2 2 2
MIRT673101 SYNPO2L synaptopodin 2 like 2 2
MIRT673437 APAF1 apoptotic peptidase activating factor 1 2 2
MIRT673584 KDELC2 KDEL motif containing 2 2 2
MIRT673718 SLU7 SLU7 homolog, splicing factor 2 2
MIRT673777 MRPL17 mitochondrial ribosomal protein L17 2 2
MIRT674316 IMP4 IMP4, U3 small nucleolar ribonucleoprotein 2 2
MIRT674820 FAM229B family with sequence similarity 229 member B 2 2
MIRT675179 BPTF bromodomain PHD finger transcription factor 2 2
MIRT675586 WWC1 WW and C2 domain containing 1 2 2
MIRT675812 MED28 mediator complex subunit 28 2 2
MIRT677632 ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 2 2
MIRT683914 PSMB9 proteasome subunit beta 9 2 2
MIRT687135 QPCTL glutaminyl-peptide cyclotransferase like 2 2
MIRT691973 PLCXD1 phosphatidylinositol specific phospholipase C X domain containing 1 2 2
MIRT693078 AS3MT arsenite methyltransferase 2 2
MIRT694084 RNASEH2B ribonuclease H2 subunit B 2 2
MIRT696292 IER3IP1 immediate early response 3 interacting protein 1 2 2
MIRT696541 C3 complement C3 2 2
MIRT701955 MITF melanogenesis associated transcription factor 2 2
MIRT703276 GNG12 G protein subunit gamma 12 2 2
MIRT706852 DNAJB13 DnaJ heat shock protein family (Hsp40) member B13 2 2
MIRT706993 XPO5 exportin 5 2 2
MIRT710716 KRTAP6-1 keratin associated protein 6-1 2 2
MIRT711305 ACOX1 acyl-CoA oxidase 1 2 2
MIRT711514 ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 2 2
MIRT711648 LIPG lipase G, endothelial type 2 2
MIRT711772 CCDC59 coiled-coil domain containing 59 2 2
MIRT714280 COQ7 coenzyme Q7, hydroxylase 2 2
MIRT715048 PRPF38A pre-mRNA processing factor 38A 2 2
MIRT716934 INCENP inner centromere protein 2 2
MIRT717220 OTUD3 OTU deubiquitinase 3 2 2
MIRT717865 BICD2 BICD cargo adaptor 2 2 2
MIRT718836 SNX20 sorting nexin 20 2 2
MIRT720243 GPBP1 GC-rich promoter binding protein 1 2 2
MIRT721969 MCM8 minichromosome maintenance 8 homologous recombination repair factor 2 2
MIRT724000 LMTK2 lemur tyrosine kinase 2 2 2
MIRT725193 SDAD1 SDA1 domain containing 1 2 2
MIRT731669 CBL Cbl proto-oncogene 3 1
MIRT732776 AQP4 aquaporin 4 3 0
MIRT733158 ITGA5 integrin subunit alpha 5 1 0
MIRT735623 TLR4 toll like receptor 4 4 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-216a Curcumin NULL 969516 Quantitative real-time PCR Y79 RB cells. 22510010 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-216a Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (SKOV3, 2008, OVCAR10, OVCAR3, HeLa, MCF7, MDA-MB-468)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-216a-5p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved sensitive High Small Cell Lung Cancer cell line (NCI-H69)
hsa-miR-216a-5p Sorafenib 216239 NSC747971 approved resistant Low Hepatocellular Carcinoma tissue and cell line (HepG2, Hep3B, Huh-7, PLC/PRF/5, HCCLM3, Bel-7404, HLE, SK-HEP-1, SNU-449)
hsa-miR-216a-5p Fluorouracil 3385 NSC19893 approved resistant High Colorectal Cancer tissue
hsa-miR-216a-5p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer tissue
hsa-miR-216a-5p Sorafenib 216239 NSC747971 approved resistant High Hepatocellular Carcinoma cell line (Huh-7)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved resistant Low Small Cell Lung Cancer cell line (H69, H446)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant Low Ovarian Cancer cell line (SKOV3, OVCA433)
hsa-miR-216a-5p Oxaliplatin 6857599 NSC266046 approved resistant Low Gastric Cancer cell line (MGC, SGC)
hsa-miR-216a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM11)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM43)
hsa-miR-216a-5p Exemestane 60198 NSC713563 approved sensitive cell line (MCF-7)
hsa-miR-216a-5p Testosterone+Tamoxifen sensitive cell line (MCF-7)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (RPMI2650)
hsa-miR-216a-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (TamR8)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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