miRTarBase - #MIRT473156


—
pre-miRNA Information
pre-miRNA hsa-mir-4481   
Genomic Coordinates chr10: 12653138 - 12653197
Description Homo sapiens miR-4481 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4481
Sequence 1| GGAGUGGGCUGGUGGUU |17
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1299710636 5 dbSNP
rs1433739601 12 dbSNP
rs1266754238 14 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol MLLT1   
Synonyms ENL, LTG19, YEATS1
Description MLLT1, super elongation complex subunit
Transcript NM_005934   
Expression
Putative miRNA Targets on MLLT1
3'UTR of MLLT1
(miRNA target sites are highlighted)		 
>MLLT1|NM_005934|3'UTR
   1 CCCTGGGCCGCGTGCCGGGCCCCCACCGCCGGGGTCCTGGGAGGCTGCAGCCAGGCCTCGCCTGCCCTCCTCTCCCGTCT
  81 CGCCTGCCCGCAGCACTGCCTTAGCGACAGCCCTGTCCTCGCCCGCACAGCCCGCTGCACTTTCCTCGGCGGCTCCCTGC
 161 CCACTCTCCCCGCTCCATCGCCAGGAGCCCTGGGGCCGGGCTGGGCCACACGGGAGCCGCCCCCCGGGCTCTCTGGGCTC
 241 CCCTCAGAGAGCGGCTGGTGTTGAAGGCAGCTCTGGGCAGAGACAGGGCCGGGGGCCCCTCGCCCAGCCTTGGGACCAGC
 321 CCCCACTGCTCGGCGGGCTGTGCGGCGTCGCTGCCCCAGCCTTTCTGAGCAGCGGATCGACGGCTGGGGGGCATCTCCAG
 401 CCTCCCGAATGGTTCAGAACACACCCTCCGCCCACCCTGGACCTCAGAAGGCCCTGCCTGTGTGTCTGCGTCGTCCTCCG
 481 TGTAGACCTAGCGCCGGCTCCTCCCCGGCTCGCGCTGCGCTGGGGTCTGTGCTGTATAGTTCTCTCTATTATATATGTGT
 561 GTGCACTGTCTGGTCAAGAGCAGTGTCCATGTGCGTTTCTGTGGCAGCAGTGCACGTGGGGTGGGTGGGGGGTGCGTACG
 641 GTGGGGCTTGTAGGTTAAGATGTCTCTGCGGTGGTGTGGGGCTGGAGGCCGAGCCAGGCACGGCAGCTGGCCCTCTCCAG
 721 GCGCATGGAGGAATTCTCCCTTTGCCGTTCCAAGGATGCCGCCGCCTCCTACCGGGGCTCCCGGGGGGGTCAGCCAACAC
 801 TACAAAGGGCAGCGAGTCCTCAGGGCGCCCGGGAGCCACCAGTCTGCTCTCGGGCTCTACTCAGACTAGCGCCAACAGTC
 881 TCCGCGGACAGACTCGCATCAGCCGCCCTGGGGCTCGGCCTCCTCCCATAGGCTCCTCTTCCTCTCTTTCATTCAAGTCT
 961 TCAAACTTTGAAAAAAATATGAGCTTTTGCCAAATAAGACGGGATAGTTTATGGAGTTTTCTGAGGCGCATTGAACTCTG
1041 GTCAGCCCCTCGAGCGTGGGCTCGGCCATCAGCAGGCCCGGTGGGTTGGCCGGGCTGGCCCTCCCAGGCTGCCTTTCTCT
1121 CTGGTCGCGGCCTGGCCCGCCCCGGCCTCCACCGCCGCAATTCATGCTGGTGCCGCGCCCGCAGCCCCACTCCTGGTATG
1201 CCTGAGATTCTCCAGGGGCCAAGCCGGTCCTCCTTCCCGGCCCACTCTTCCAGGGCCAGGACGCTCCCGCGGAGCCAGCC
1281 CATCGTGGCTGGGGGTCCCAGGGGCTGGAGGCCTGCCTGGTTAGCCTCTGTTTCCCAGACATTGACTCGAGGCGCCTCCA
1361 GTCCTCTCAACCCCCTGACTTTCAAGTCCTTTCAAGTCCTTGTGCCCTGACCAAGTTATGAGGAAAAGAGGGCTGAGGGC
1441 CTGGAGGTGGGCTCGCACCCCCTCGAACCCACCTAGATGTCTCCTCCTCCCCAGCCTATGAGTTCAGACTTGGGGGGCTC
1521 CATCTGTCCCTCCCTGAGGTCCCTCATCTTGTCCCTGCTCTGATTCTGTCAGCAGATCCTGAACACTCCTTGGTGGGGAC
1601 CCATGCCTCCAAGGCTGCCCCCAATGCCAGCTGTCCTGGGGAAACTCCCCAGAACTCTCGGGGAAAGGCCCGAGAACCTT
1681 CGGAGGAAGCCTCCGGGACTCCTCGCCACCTGCTCTGTTTCTCTCCCGGCCCCACTGCCTTCAGGTATCAGGAAGAGGGC
1761 AGGCCCCTGTGCCCCCTCTCCCCTTCCCAGGGCGGCCAACAATACTCCACCATGGGGCGCTTCCTTTCTTCTCTGGAAAC
1841 TAAGACATTGGACTGAAGGAACTGGCCTGAGGGGGGCTGACCGGGGGCCCGTGCTGCTGGGAGCTCTACGCACAAGAGGC
1921 CGCCGGGGTCACGGACAGGAACCTCAGCCCAGGGTGCTGGCCTTTCTCCTTCGCAGGAGTCCCCCAAAATCCACACAGCG
2001 ACTCGAGCAGCCTTCCACTCAGCCAGAGGAGGGTCGGGCTCCCCCGCCTGCTCTCGGTGGTGGCGTCTGGCCCTTCCTGC
2081 CGTTTCCAAGGCCTCCGGAAGCACCAACCCAGTTCTCAGTTACCTCCTCTGGCCGGAAGGCCTCACGTTGTCCTCCAGAG
2161 CTGCTCTGGGCCCAGGGCTGGCTCCGTGACCACCTGATGGACGTGCTGGGCAGCATGGGCTCCCAAGGCAGCATCCCCAG
2241 CTGCTCTCCCACCCCACCCCAGCTGCCCGGCGGCTGGGCCCACGAGGGCTCTGGGGACACTTCCATAGGAAAGGGGCCTG
2321 GCACTTTGTGATTGCCACGTGTTTCCTGTTAAGCCGCCTGCCCCCAGTGCAAATCTCTGTGTTTTGCTCTCTCCTGAACA
2401 AAAATGTAAACCGACGCCGGAAAGCAAATGGTATCGAATACCTTTCTTGCCCATAAGGGTTTTTACAAAGAACGTGTCTC
2481 ACTAGGAACTAGGACACTCATCGGCCCGAGACCAACTCCTGGATAAAAGGAATAAGGAGAATCGTGTTTGTAACGAGTTA
2561 CAGGATTGTTTCTTTCCTGGATTTTAAACTTTTGTTAAATTGTGAAATTATGGAGGAGTTTTATAGAAAAAAAAAGTGAA
2641 ATAAAGTCAGATGGGAAAGCAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uugguGGUCGGGUGAGg 5'
               ||:|||||||| 
Target 5' ccttcCCGGCCCACTCt 3'
 1232 - 1248 156.00 -22.40
2 
miRNA  3' uuGGUGGUCGGGUGAGg 5'
            |: || |||||||| 
Target 5' ggCTCCCTGCCCACTCt 3'
 151 - 167 155.00 -20.00
3 
miRNA  3' uuGGUGGUCGGGUGAGg 5'
            ||:| : ||||||| 
Target 5' gcCCGCAGCCCCACTCc 3'
 1177 - 1193 151.00 -21.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30544743 1 COSMIC
COSN20335490 10 COSMIC
COSN30761742 11 COSMIC
COSN30479188 15 COSMIC
COSN30704437 36 COSMIC
COSN31537425 60 COSMIC
COSN30187911 73 COSMIC
COSN26984709 76 COSMIC
COSN29028418 195 COSMIC
COSN20949528 407 COSMIC
COSN29048953 473 COSMIC
COSN20115374 674 COSMIC
COSN26858028 674 COSMIC
COSN31540825 675 COSMIC
COSN20566278 680 COSMIC
COSN27275389 763 COSMIC
COSN28804679 771 COSMIC
COSN31555378 830 COSMIC
COSN27270620 1447 COSMIC
COSN31609668 1465 COSMIC
COSN31568942 1681 COSMIC
COSN31573046 1727 COSMIC
COSN26818100 2027 COSMIC
COSN7451434 2134 COSMIC
COSN31528411 2412 COSMIC
COSN6148225 2419 COSMIC
COSN31661974 2627 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1402873089 2 dbSNP
rs1386662797 4 dbSNP
rs747273547 5 dbSNP
rs776081296 9 dbSNP
rs746374882 10 dbSNP
rs778607196 11 dbSNP
rs538172906 12 dbSNP
rs371710480 16 dbSNP
rs755948099 17 dbSNP
rs1448579375 18 dbSNP
rs752491408 19 dbSNP
rs1213349524 23 dbSNP
rs1487880079 24 dbSNP
rs767336132 26 dbSNP
rs569544639 27 dbSNP
rs751471718 28 dbSNP
rs1317832849 29 dbSNP
rs761845242 30 dbSNP
rs376013804 31 dbSNP
rs1329748976 32 dbSNP
rs371417994 39 dbSNP
rs760941330 40 dbSNP
rs1439644132 42 dbSNP
rs1394779394 43 dbSNP
rs1327253057 50 dbSNP
rs552882897 59 dbSNP
rs1035627159 60 dbSNP
rs532792345 67 dbSNP
rs1174818048 68 dbSNP
rs1278313125 70 dbSNP
rs1418317974 72 dbSNP
rs567062980 76 dbSNP
rs546828523 77 dbSNP
rs1010955268 78 dbSNP
rs1273674564 79 dbSNP
rs201403290 81 dbSNP
rs373623171 82 dbSNP
rs1281029815 88 dbSNP
rs1352692000 89 dbSNP
rs561132813 96 dbSNP
rs1052438755 105 dbSNP
rs1447746164 106 dbSNP
rs1198436553 120 dbSNP
rs1381119708 121 dbSNP
rs934600124 124 dbSNP
rs544558306 125 dbSNP
rs111731371 131 dbSNP
rs1446859442 134 dbSNP
rs1040242923 137 dbSNP
rs1400862355 139 dbSNP
rs1003683380 143 dbSNP
rs1347600267 144 dbSNP
rs943217067 147 dbSNP
rs562468241 148 dbSNP
rs910353489 150 dbSNP
rs545676548 151 dbSNP
rs1281010949 155 dbSNP
rs1417673452 156 dbSNP
rs1209461308 167 dbSNP
rs1288061320 170 dbSNP
rs369714857 171 dbSNP
rs767169849 172 dbSNP
rs971744054 175 dbSNP
rs1037368764 178 dbSNP
rs961272356 179 dbSNP
rs576667088 180 dbSNP
rs1364731734 181 dbSNP
rs1472706708 190 dbSNP
rs1035290479 197 dbSNP
rs1255753987 198 dbSNP
rs980992583 209 dbSNP
rs553928975 211 dbSNP
rs1330894167 212 dbSNP
rs1022467497 213 dbSNP
rs1011442214 218 dbSNP
rs892538516 219 dbSNP
rs1337159972 221 dbSNP
rs181896434 225 dbSNP
rs1257427680 226 dbSNP
rs915254066 226 dbSNP
rs1227315040 227 dbSNP
rs372947827 231 dbSNP
rs959732163 237 dbSNP
rs998212560 237 dbSNP
rs574441902 242 dbSNP
rs1033744266 243 dbSNP
rs1359393686 244 dbSNP
rs1288757612 245 dbSNP
rs1422284900 247 dbSNP
rs1460078692 248 dbSNP
rs12985321 249 dbSNP
rs1040273718 252 dbSNP
rs970833280 253 dbSNP
rs554291670 257 dbSNP
rs952072869 259 dbSNP
rs1357137021 263 dbSNP
rs1415621580 270 dbSNP
rs888989106 272 dbSNP
rs1277864875 279 dbSNP
rs1351925547 283 dbSNP
rs189668350 287 dbSNP
rs568857920 290 dbSNP
rs559335142 291 dbSNP
rs761964406 292 dbSNP
rs539340287 296 dbSNP
rs377430237 297 dbSNP
rs1262083695 298 dbSNP
rs927574685 299 dbSNP
rs1194635623 300 dbSNP
rs888867107 303 dbSNP
rs1465423543 304 dbSNP
rs1261150931 310 dbSNP
rs1051490690 316 dbSNP
rs1377032040 317 dbSNP
rs1435152582 321 dbSNP
rs1203249345 322 dbSNP
rs997260135 324 dbSNP
rs903059915 325 dbSNP
rs566957384 326 dbSNP
rs1489424379 330 dbSNP
rs981058203 331 dbSNP
rs969620409 332 dbSNP
rs1266034556 334 dbSNP
rs915440970 335 dbSNP
rs947316193 338 dbSNP
rs1332481407 340 dbSNP
rs1284364975 341 dbSNP
rs914468727 343 dbSNP
rs369227157 344 dbSNP
rs937985622 346 dbSNP
rs530150155 347 dbSNP
rs982193386 348 dbSNP
rs1031097129 349 dbSNP
rs998641890 350 dbSNP
rs972191757 351 dbSNP
rs1455483831 356 dbSNP
rs1390095414 361 dbSNP
rs965353114 373 dbSNP
rs1018229586 374 dbSNP
rs1007468274 378 dbSNP
rs1016478321 379 dbSNP
rs1240091895 380 dbSNP
rs889021245 381 dbSNP
rs953107535 382 dbSNP
rs1294678351 385 dbSNP
rs1260995844 386 dbSNP
rs770765865 388 dbSNP
rs994698652 391 dbSNP
rs1254355057 392 dbSNP
rs1392778687 395 dbSNP
rs1173029689 397 dbSNP
rs902923754 398 dbSNP
rs567717996 404 dbSNP
rs768702134 406 dbSNP
rs760428868 407 dbSNP
rs1420718186 414 dbSNP
rs1011393890 428 dbSNP
rs893043914 429 dbSNP
rs1026700804 430 dbSNP
rs1055679289 443 dbSNP
rs749033338 450 dbSNP
rs939095051 458 dbSNP
rs1466942461 460 dbSNP
rs1259777301 464 dbSNP
rs185247037 469 dbSNP
rs1312496259 470 dbSNP
rs550772959 472 dbSNP
rs530847278 473 dbSNP
rs1274436059 475 dbSNP
rs576614298 479 dbSNP
rs1334995992 482 dbSNP
rs1197923214 488 dbSNP
rs963544115 492 dbSNP
rs915512970 495 dbSNP
rs990108386 496 dbSNP
rs956900563 497 dbSNP
rs556706750 499 dbSNP
rs564926487 505 dbSNP
rs924064359 506 dbSNP
rs555745941 507 dbSNP
rs953741730 512 dbSNP
rs1369157116 513 dbSNP
rs965428007 514 dbSNP
rs1030033450 521 dbSNP
rs1443587141 523 dbSNP
rs1448065618 525 dbSNP
rs773063551 531 dbSNP
rs1353964383 536 dbSNP
rs1412538240 542 dbSNP
rs1294811617 544 dbSNP
rs1011831241 548 dbSNP
rs967139185 548 dbSNP
rs374479266 551 dbSNP
rs1166424681 554 dbSNP
rs1467624335 555 dbSNP
rs1006827335 557 dbSNP
rs1484601483 558 dbSNP
rs952692198 562 dbSNP
rs893002019 565 dbSNP
rs1258535251 572 dbSNP
rs1034591904 573 dbSNP
rs1027586779 587 dbSNP
rs995130178 588 dbSNP
rs897695787 589 dbSNP
rs1239703138 590 dbSNP
rs1015162376 595 dbSNP
rs1003322527 604 dbSNP
rs907101763 607 dbSNP
rs906263955 610 dbSNP
rs1044810755 615 dbSNP
rs1429619720 616 dbSNP
rs1247939909 617 dbSNP
rs1201855362 618 dbSNP
rs947713386 619 dbSNP
rs532226699 627 dbSNP
rs1302641724 628 dbSNP
rs897922111 632 dbSNP
rs1212700339 633 dbSNP
rs1346334906 633 dbSNP
rs560106516 635 dbSNP
rs942107421 637 dbSNP
rs1243918588 639 dbSNP
rs1447958762 640 dbSNP
rs1054042041 641 dbSNP
rs1393851833 644 dbSNP
rs1174604529 647 dbSNP
rs1455992568 647 dbSNP
rs1360302498 650 dbSNP
rs909406949 668 dbSNP
rs1315854502 669 dbSNP
rs935581651 670 dbSNP
rs376938247 674 dbSNP
rs376205661 677 dbSNP
rs200472148 678 dbSNP
rs3833294 678 dbSNP
rs397816296 678 dbSNP
rs923495720 690 dbSNP
rs975751551 691 dbSNP
rs1402932037 693 dbSNP
rs1312357461 701 dbSNP
rs977313802 702 dbSNP
rs1213107373 707 dbSNP
rs1382070442 710 dbSNP
rs1470177937 714 dbSNP
rs944151760 714 dbSNP
rs1363580872 717 dbSNP
rs911325898 718 dbSNP
rs540395702 722 dbSNP
rs1019951854 723 dbSNP
rs989953306 724 dbSNP
rs952723775 725 dbSNP
rs1189117424 731 dbSNP
rs1027363310 734 dbSNP
rs574525032 737 dbSNP
rs1326567000 738 dbSNP
rs1001744667 743 dbSNP
rs1439807566 745 dbSNP
rs1442642653 746 dbSNP
rs139146982 747 dbSNP
rs1232915374 750 dbSNP
rs907145841 760 dbSNP
rs533738168 763 dbSNP
rs962255603 764 dbSNP
rs1014782743 767 dbSNP
rs11553930 771 dbSNP
rs1224859970 772 dbSNP
rs200837582 772 dbSNP
rs906333863 773 dbSNP
rs372031473 774 dbSNP
rs549158045 774 dbSNP
rs558549170 774 dbSNP
rs1414999896 776 dbSNP
rs1011962477 778 dbSNP
rs1036754467 783 dbSNP
rs1395640458 784 dbSNP
rs1278160880 785 dbSNP
rs1247179792 788 dbSNP
rs893510371 789 dbSNP
rs942157789 790 dbSNP
rs1291728004 795 dbSNP
rs1357411250 796 dbSNP
rs1250852183 799 dbSNP
rs181103791 813 dbSNP
rs1050636780 814 dbSNP
rs1274142300 818 dbSNP
rs35855287 823 dbSNP
rs1362570345 826 dbSNP
rs1298680338 827 dbSNP
rs932106034 830 dbSNP
rs558543840 831 dbSNP
rs539352598 836 dbSNP
rs1187583769 837 dbSNP
rs1372015534 841 dbSNP
rs567117201 841 dbSNP
rs935626945 848 dbSNP
rs902747445 851 dbSNP
rs1041260525 852 dbSNP
rs1310874827 857 dbSNP
rs1377451965 859 dbSNP
rs376618984 870 dbSNP
rs1473035542 871 dbSNP
rs912923379 877 dbSNP
rs1416684062 879 dbSNP
rs553309979 883 dbSNP
rs1230240135 884 dbSNP
rs527522621 884 dbSNP
rs1271331690 885 dbSNP
rs1347575911 886 dbSNP
rs957155095 887 dbSNP
rs1282945179 889 dbSNP
rs911357160 895 dbSNP
rs1263305265 896 dbSNP
rs1468963766 896 dbSNP
rs979962061 902 dbSNP
rs985514082 904 dbSNP
rs1426281943 905 dbSNP
rs1195212826 906 dbSNP
rs1024090858 909 dbSNP
rs1453745366 910 dbSNP
rs931388395 914 dbSNP
rs567740809 916 dbSNP
rs1282850863 917 dbSNP
rs550701238 925 dbSNP
rs919967287 927 dbSNP
rs879246367 928 dbSNP
rs537145109 932 dbSNP
rs1321337550 941 dbSNP
rs961378575 948 dbSNP
rs1015266837 950 dbSNP
rs189722418 951 dbSNP
rs114406449 954 dbSNP
rs1023470019 957 dbSNP
rs996252553 963 dbSNP
rs1292859012 970 dbSNP
rs1012038008 976 dbSNP
rs1248119563 977 dbSNP
rs532296125 980 dbSNP
rs902049790 981 dbSNP
rs958016251 991 dbSNP
rs753917709 1000 dbSNP
rs748137429 1001 dbSNP
rs1362240067 1002 dbSNP
rs1208555820 1003 dbSNP
rs146185055 1007 dbSNP
rs1430182439 1010 dbSNP
rs902148416 1013 dbSNP
rs1054146718 1020 dbSNP
rs935626062 1021 dbSNP
rs1368723463 1027 dbSNP
rs369124109 1027 dbSNP
rs1008396404 1028 dbSNP
rs1393501663 1030 dbSNP
rs1268203065 1031 dbSNP
rs1333586115 1036 dbSNP
rs1211715097 1042 dbSNP
rs1162291460 1051 dbSNP
rs971103828 1052 dbSNP
rs1423641041 1053 dbSNP
rs566743895 1054 dbSNP
rs1356119371 1055 dbSNP
rs376314725 1056 dbSNP
rs931438171 1059 dbSNP
rs1248170266 1060 dbSNP
rs756412388 1063 dbSNP
rs1037090593 1064 dbSNP
rs1417235940 1073 dbSNP
rs1459989611 1079 dbSNP
rs76868357 1080 dbSNP
rs928611791 1084 dbSNP
rs1469146976 1086 dbSNP
rs1461931017 1090 dbSNP
rs1296742320 1091 dbSNP
rs1272960035 1092 dbSNP
rs1376068072 1101 dbSNP
rs1411258218 1103 dbSNP
rs373273964 1105 dbSNP
rs1230881173 1109 dbSNP
rs952175992 1110 dbSNP
rs184943077 1111 dbSNP
rs1249403643 1113 dbSNP
rs996284640 1115 dbSNP
rs1481526878 1117 dbSNP
rs544329441 1119 dbSNP
rs575371667 1120 dbSNP
rs1474368141 1126 dbSNP
rs1010384310 1127 dbSNP
rs957874551 1128 dbSNP
rs1169026667 1129 dbSNP
rs1032522573 1130 dbSNP
rs999250648 1139 dbSNP
rs1276504582 1140 dbSNP
rs966781686 1142 dbSNP
rs1441580601 1143 dbSNP
rs1019238223 1144 dbSNP
rs1285384621 1145 dbSNP
rs142138634 1146 dbSNP
rs1008461503 1147 dbSNP
rs890017559 1151 dbSNP
rs564887489 1153 dbSNP
rs1344001446 1154 dbSNP
rs936265059 1154 dbSNP
rs1205561472 1155 dbSNP
rs996092011 1156 dbSNP
rs544990640 1157 dbSNP
rs1044027844 1160 dbSNP
rs949816850 1168 dbSNP
rs916975300 1169 dbSNP
rs533287126 1174 dbSNP
rs1407683582 1175 dbSNP
rs1037522747 1176 dbSNP
rs11085164 1177 dbSNP
rs181563471 1180 dbSNP
rs1045751187 1181 dbSNP
rs1335848332 1181 dbSNP
rs1429466267 1183 dbSNP
rs953967411 1187 dbSNP
rs1029436095 1196 dbSNP
rs974712329 1199 dbSNP
rs1252993110 1205 dbSNP
rs1192126860 1206 dbSNP
rs949307079 1210 dbSNP
rs1279648160 1215 dbSNP
rs916521585 1216 dbSNP
rs1213665315 1217 dbSNP
rs1249994533 1218 dbSNP
rs1465694318 1222 dbSNP
rs536535951 1225 dbSNP
rs990725788 1226 dbSNP
rs958119222 1227 dbSNP
rs925102260 1229 dbSNP
rs190251082 1237 dbSNP
rs1234852473 1238 dbSNP
rs891999840 1239 dbSNP
rs1368471664 1248 dbSNP
rs1438294136 1253 dbSNP
rs966480075 1260 dbSNP
rs372861915 1262 dbSNP
rs185402762 1263 dbSNP
rs537155690 1268 dbSNP
rs747137800 1269 dbSNP
rs953684276 1270 dbSNP
rs1213596507 1271 dbSNP
rs1439586188 1283 dbSNP
rs1028537723 1284 dbSNP
rs995732831 1285 dbSNP
rs751951267 1290 dbSNP
rs1199967536 1295 dbSNP
rs571380387 1296 dbSNP
rs1232680094 1302 dbSNP
rs1469304224 1305 dbSNP
rs898697908 1306 dbSNP
rs1179641630 1310 dbSNP
rs551440516 1314 dbSNP
rs1004732389 1326 dbSNP
rs949684388 1327 dbSNP
rs535052424 1330 dbSNP
rs895579647 1330 dbSNP
rs1394979803 1334 dbSNP
rs907269481 1339 dbSNP
rs1163616390 1341 dbSNP
rs377744259 1342 dbSNP
rs1045826381 1348 dbSNP
rs1409204831 1349 dbSNP
rs780237893 1353 dbSNP
rs1479785389 1354 dbSNP
rs894447356 1360 dbSNP
rs1351153050 1367 dbSNP
rs1055457489 1370 dbSNP
rs936601288 1375 dbSNP
rs758683094 1383 dbSNP
rs1211027097 1384 dbSNP
rs543238278 1388 dbSNP
rs565927228 1389 dbSNP
rs1436476554 1392 dbSNP
rs76739776 1401 dbSNP
rs1202546596 1402 dbSNP
rs546922372 1404 dbSNP
rs932572384 1406 dbSNP
rs921157739 1407 dbSNP
rs1366205763 1411 dbSNP
rs1473735425 1415 dbSNP
rs750613883 1419 dbSNP
rs912322599 1420 dbSNP
rs1408039914 1428 dbSNP
rs533049260 1430 dbSNP
rs953716843 1431 dbSNP
rs1018948632 1435 dbSNP
rs765660492 1441 dbSNP
rs1306028872 1444 dbSNP
rs1221928319 1448 dbSNP
rs1291447283 1449 dbSNP
rs879373552 1454 dbSNP
rs529902929 1455 dbSNP
rs561073576 1456 dbSNP
rs544626099 1462 dbSNP
rs1016201521 1464 dbSNP
rs1275814561 1465 dbSNP
rs1483139733 1469 dbSNP
rs1004404512 1470 dbSNP
rs1000346290 1472 dbSNP
rs550762594 1476 dbSNP
rs907341619 1484 dbSNP
rs906113688 1485 dbSNP
rs1188128659 1486 dbSNP
rs1372393037 1489 dbSNP
rs1373124092 1495 dbSNP
rs1447613050 1496 dbSNP
rs530643101 1499 dbSNP
rs1170188321 1506 dbSNP
rs1024403972 1509 dbSNP
rs1390566871 1510 dbSNP
rs1434324010 1512 dbSNP
rs1301362270 1516 dbSNP
rs1455819441 1517 dbSNP
rs1023141257 1529 dbSNP
rs1396635315 1532 dbSNP
rs1317749515 1538 dbSNP
rs754341852 1542 dbSNP
rs192661485 1545 dbSNP
rs1298789469 1548 dbSNP
rs1158830196 1551 dbSNP
rs545106171 1553 dbSNP
rs1417769176 1555 dbSNP
rs572833255 1558 dbSNP
rs939792423 1560 dbSNP
rs936615224 1562 dbSNP
rs1048720308 1564 dbSNP
rs903785435 1567 dbSNP
rs1463439866 1569 dbSNP
rs139770948 1575 dbSNP
rs945217451 1576 dbSNP
rs1453613722 1581 dbSNP
rs1173726917 1586 dbSNP
rs912353577 1590 dbSNP
rs1379535230 1593 dbSNP
rs1255506628 1595 dbSNP
rs1466756769 1599 dbSNP
rs986552517 1607 dbSNP
rs921190230 1611 dbSNP
rs932394556 1618 dbSNP
rs1370677695 1621 dbSNP
rs1439109932 1622 dbSNP
rs529395413 1624 dbSNP
rs973744514 1626 dbSNP
rs559083325 1633 dbSNP
rs543308114 1636 dbSNP
rs988800432 1639 dbSNP
rs1259627384 1642 dbSNP
rs1326516249 1643 dbSNP
rs1213359161 1644 dbSNP
rs956339607 1645 dbSNP
rs1467992671 1648 dbSNP
rs1189184601 1654 dbSNP
rs1269206986 1659 dbSNP
rs575290946 1659 dbSNP
rs78726791 1660 dbSNP
rs982998497 1662 dbSNP
rs1458924254 1668 dbSNP
rs971558421 1671 dbSNP
rs1024479046 1672 dbSNP
rs979348276 1673 dbSNP
rs192620163 1679 dbSNP
rs958767198 1681 dbSNP
rs1033486255 1682 dbSNP
rs1000212101 1685 dbSNP
rs1382364147 1686 dbSNP
rs1363254550 1692 dbSNP
rs1348273152 1693 dbSNP
rs141540024 1694 dbSNP
rs1042307833 1695 dbSNP
rs1452044248 1697 dbSNP
rs2304153 1704 dbSNP
rs890991937 1705 dbSNP
rs888194432 1709 dbSNP
rs1050871143 1710 dbSNP
rs1416042161 1715 dbSNP
rs932425556 1717 dbSNP
rs1048108763 1727 dbSNP
rs996992726 1728 dbSNP
rs774071986 1731 dbSNP
rs899706423 1732 dbSNP
rs1195394392 1735 dbSNP
rs1182917591 1743 dbSNP
rs1417261629 1747 dbSNP
rs1422581028 1749 dbSNP
rs866572244 1757 dbSNP
rs866188746 1771 dbSNP
rs943949634 1773 dbSNP
rs1461760855 1780 dbSNP
rs921042306 1793 dbSNP
rs1038499797 1794 dbSNP
rs1260919046 1801 dbSNP
rs1184739589 1802 dbSNP
rs1469608042 1806 dbSNP
rs941045516 1807 dbSNP
rs1308105062 1809 dbSNP
rs908164573 1811 dbSNP
rs1253411805 1818 dbSNP
rs1212608692 1828 dbSNP
rs1332214318 1846 dbSNP
rs1227333238 1860 dbSNP
rs1272226745 1861 dbSNP
rs983073620 1864 dbSNP
rs971633562 1867 dbSNP
rs917453510 1870 dbSNP
rs925940423 1871 dbSNP
rs1482347792 1872 dbSNP
rs1227495758 1873 dbSNP
rs978910113 1882 dbSNP
rs1428450819 1887 dbSNP
rs1167026035 1888 dbSNP
rs991639313 1889 dbSNP
rs540796491 1890 dbSNP
rs1431240803 1891 dbSNP
rs1168888868 1893 dbSNP
rs1358039262 1896 dbSNP
rs762681093 1903 dbSNP
rs1445123519 1904 dbSNP
rs916105758 1906 dbSNP
rs577801582 1909 dbSNP
rs1434289266 1911 dbSNP
rs1295129020 1912 dbSNP
rs1344123379 1914 dbSNP
rs566272458 1916 dbSNP
rs1000647514 1921 dbSNP
rs186787410 1922 dbSNP
rs1020234223 1924 dbSNP
rs1392520999 1925 dbSNP
rs1169908767 1928 dbSNP
rs534805375 1932 dbSNP
rs867412753 1933 dbSNP
rs1187290117 1950 dbSNP
rs1250262679 1954 dbSNP
rs1027064402 1956 dbSNP
rs996638210 1961 dbSNP
rs899555709 1969 dbSNP
rs1412413265 1972 dbSNP
rs1040918599 1973 dbSNP
rs891023013 1973 dbSNP
rs111522379 1976 dbSNP
rs1168159178 1977 dbSNP
rs892396906 1978 dbSNP
rs1367059343 1982 dbSNP
rs753989141 1986 dbSNP
rs149591366 1987 dbSNP
rs536565400 1991 dbSNP
rs1052399490 1999 dbSNP
rs74819842 2000 dbSNP
rs1221216602 2001 dbSNP
rs1038126831 2004 dbSNP
rs941105662 2005 dbSNP
rs908238777 2007 dbSNP
rs1207349975 2012 dbSNP
rs1192762068 2016 dbSNP
rs1046753081 2019 dbSNP
rs1198531901 2023 dbSNP
rs1252197311 2025 dbSNP
rs950306118 2026 dbSNP
rs1476835312 2030 dbSNP
rs375395362 2036 dbSNP
rs1196052034 2038 dbSNP
rs1043435535 2039 dbSNP
rs917525551 2045 dbSNP
rs1156342576 2046 dbSNP
rs991704700 2049 dbSNP
rs937525615 2055 dbSNP
rs915970039 2056 dbSNP
rs1249130187 2062 dbSNP
rs1389759286 2064 dbSNP
rs550870302 2065 dbSNP
rs1234865379 2067 dbSNP
rs1350659962 2072 dbSNP
rs1304867311 2073 dbSNP
rs112740825 2074 dbSNP
rs1002360001 2075 dbSNP
rs1369282048 2076 dbSNP
rs747931599 2082 dbSNP
rs1290309820 2094 dbSNP
rs983093718 2095 dbSNP
rs1209837034 2096 dbSNP
rs1288155492 2097 dbSNP
rs967852822 2097 dbSNP
rs1020265152 2115 dbSNP
rs763911393 2118 dbSNP
rs571455386 2124 dbSNP
rs1392192644 2125 dbSNP
rs987450618 2126 dbSNP
rs1482530264 2127 dbSNP
rs551501090 2128 dbSNP
rs954682890 2132 dbSNP
rs1029543068 2134 dbSNP
rs573388181 2135 dbSNP
rs559309281 2144 dbSNP
rs1406836659 2146 dbSNP
rs1323990702 2147 dbSNP
rs975052749 2152 dbSNP
rs1017174697 2153 dbSNP
rs1408236943 2154 dbSNP
rs963792264 2165 dbSNP
rs1351248272 2173 dbSNP
rs1452302363 2178 dbSNP
rs542223219 2185 dbSNP
rs768634117 2186 dbSNP
rs1365349737 2190 dbSNP
rs886842423 2191 dbSNP
rs1046825327 2194 dbSNP
rs1019341766 2197 dbSNP
rs1007974812 2201 dbSNP
rs564727137 2202 dbSNP
rs747084435 2203 dbSNP
rs147042081 2207 dbSNP
rs1212373152 2212 dbSNP
rs1485733290 2228 dbSNP
rs1437945141 2230 dbSNP
rs937580142 2232 dbSNP
rs926170486 2240 dbSNP
rs1186266002 2244 dbSNP
rs979320372 2248 dbSNP
rs1281620023 2259 dbSNP
rs946211050 2260 dbSNP
rs1235617066 2264 dbSNP
rs913331735 2268 dbSNP
rs1043078576 2269 dbSNP
rs1163911166 2270 dbSNP
rs1281641657 2271 dbSNP
rs758505268 2272 dbSNP
rs1335386575 2277 dbSNP
rs1305192895 2278 dbSNP
rs954713606 2284 dbSNP
rs1170774128 2289 dbSNP
rs1028948286 2291 dbSNP
rs975390250 2297 dbSNP
rs1416667168 2299 dbSNP
rs1376180461 2300 dbSNP
rs141524873 2304 dbSNP
rs1016794115 2305 dbSNP
rs1395490864 2305 dbSNP
rs10875 2313 dbSNP
rs1057177564 2314 dbSNP
rs1342711435 2321 dbSNP
rs1005817825 2322 dbSNP
rs886913709 2323 dbSNP
rs1297300991 2325 dbSNP
rs1432803572 2327 dbSNP
rs1340540390 2338 dbSNP
rs746136026 2339 dbSNP
rs1158914562 2341 dbSNP
rs1452847778 2351 dbSNP
rs577864627 2355 dbSNP
rs1014008709 2356 dbSNP
rs779047552 2360 dbSNP
rs1275901866 2361 dbSNP
rs895516434 2362 dbSNP
rs1184199224 2379 dbSNP
rs1247160878 2385 dbSNP
rs1055855501 2388 dbSNP
rs937632095 2390 dbSNP
rs1256209552 2392 dbSNP
rs931600361 2393 dbSNP
rs1170886373 2394 dbSNP
rs1404510264 2398 dbSNP
rs557886322 2403 dbSNP
rs920133229 2412 dbSNP
rs975084047 2413 dbSNP
rs367604184 2415 dbSNP
rs757620559 2416 dbSNP
rs752063320 2418 dbSNP
rs541527561 2419 dbSNP
rs1298816160 2435 dbSNP
rs1326584090 2442 dbSNP
rs1232162713 2449 dbSNP
rs1253730371 2452 dbSNP
rs986574540 2453 dbSNP
rs913364539 2464 dbSNP
rs956648892 2470 dbSNP
rs764693810 2473 dbSNP
rs1001081643 2474 dbSNP
rs1235400179 2481 dbSNP
rs1262244449 2484 dbSNP
rs1051836090 2485 dbSNP
rs1432803002 2487 dbSNP
rs572417341 2494 dbSNP
rs1197083741 2495 dbSNP
rs1356109036 2496 dbSNP
rs756694095 2497 dbSNP
rs1445981382 2499 dbSNP
rs1158546856 2501 dbSNP
rs1328104910 2502 dbSNP
rs751054298 2503 dbSNP
rs1318932976 2504 dbSNP
rs921967160 2507 dbSNP
rs771792409 2508 dbSNP
rs766009110 2515 dbSNP
rs1332495750 2521 dbSNP
rs1461642070 2543 dbSNP
rs1287179073 2544 dbSNP
rs1326911041 2554 dbSNP
rs1230210185 2560 dbSNP
rs373661183 2563 dbSNP
rs963389298 2565 dbSNP
rs1488056411 2566 dbSNP
rs1207872540 2576 dbSNP
rs1269673250 2582 dbSNP
rs1490578626 2592 dbSNP
rs762471665 2594 dbSNP
rs894519692 2611 dbSNP
rs1162156662 2614 dbSNP
rs1057041399 2619 dbSNP
rs1160534645 2623 dbSNP
rs1454802133 2635 dbSNP
rs1002942022 2636 dbSNP
rs1366995256 2636 dbSNP
rs1456679172 2636 dbSNP
rs887168342 2636 dbSNP
rs1405188300 2637 dbSNP
rs1306855775 2647 dbSNP
rs3177181 2662 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uuGGUGGUCGGGUGAGg 5'
            |: || |||||||| 
Target 5' ggCUCCCUGCCCACUCu 3'
 		26 - 42
2 
miRNA  3' uugGUGGUCGGGUGAgg 5'
             || ||||||:||  
Target 5' ---CA-CAGCCCGCUgc 3'
 		1 - 13
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000252674.7 | 3UTR | CACAGCCCGCUGCACUUUCCUCGGCGGCUCCCUGCCCACUCUCCCCG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
84 hsa-miR-4481 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT100715 TJAP1 tight junction associated protein 1 2 2
MIRT183589 ZC3H11A zinc finger CCCH-type containing 11A 2 2
MIRT338033 DAZAP2 DAZ associated protein 2 2 4
MIRT395796 SPCS3 signal peptidase complex subunit 3 2 2
MIRT443947 LRIT3 leucine rich repeat, Ig-like and transmembrane domains 3 2 2
MIRT450580 HIST1H2BG histone cluster 1 H2B family member g 2 6
MIRT451617 MEIS3P1 Meis homeobox 3 pseudogene 1 2 2
MIRT452331 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT453279 EFTUD2 elongation factor Tu GTP binding domain containing 2 2 2
MIRT455212 GNL1 G protein nucleolar 1 (putative) 2 2
MIRT455470 LYPLA2 lysophospholipase II 2 2
MIRT456503 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 2 2
MIRT456687 LDB1 LIM domain binding 1 2 2
MIRT456915 DDA1 DET1 and DDB1 associated 1 2 2
MIRT457603 IDS iduronate 2-sulfatase 2 2
MIRT457848 RNASEH2B ribonuclease H2 subunit B 2 4
MIRT458455 RPRM reprimo, TP53 dependent G2 arrest mediator homolog 2 2
MIRT460179 UNK unkempt family zinc finger 2 6
MIRT461465 SLC19A3 solute carrier family 19 member 3 2 2
MIRT464739 UBE2Q1 ubiquitin conjugating enzyme E2 Q1 2 2
MIRT465279 TRIM28 tripartite motif containing 28 2 2
MIRT468450 SETD1B SET domain containing 1B 2 2
MIRT468620 SUMO1 small ubiquitin-like modifier 1 2 6
MIRT469152 RNF121 ring finger protein 121 2 2
MIRT470073 PTGES2 prostaglandin E synthase 2 2 2
MIRT470172 PSMD11 proteasome 26S subunit, non-ATPase 11 2 4
MIRT473156 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT474308 LAMC1 laminin subunit gamma 1 2 2
MIRT474782 KIAA0895L KIAA0895 like 2 2
MIRT476484 GATAD2A GATA zinc finger domain containing 2A 2 2
MIRT477613 EFNA3 ephrin A3 2 2
MIRT479525 CDCA4 cell division cycle associated 4 2 2
MIRT479973 CARD10 caspase recruitment domain family member 10 2 2
MIRT480410 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT480426 C17orf85 nuclear cap binding subunit 3 2 2
MIRT483573 SYT2 synaptotagmin 2 2 2
MIRT483664 QSOX2 quiescin sulfhydryl oxidase 2 2 4
MIRT484532 POLD3 DNA polymerase delta 3, accessory subunit 2 2
MIRT484616 SIX3 SIX homeobox 3 2 6
MIRT485897 ZFP36 ZFP36 ring finger protein 2 2
MIRT486505 MYH11 myosin heavy chain 11 2 2
MIRT487505 GRK5 G protein-coupled receptor kinase 5 2 2
MIRT488852 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT489464 MSC musculin 2 2
MIRT491170 LRP3 LDL receptor related protein 3 2 2
MIRT496627 TMEM67 transmembrane protein 67 2 2
MIRT497616 ANG angiogenin 2 2
MIRT497766 KIAA0895 KIAA0895 2 2
MIRT499680 MRE11A MRE11 homolog, double strand break repair nuclease 2 6
MIRT499774 SLC29A2 solute carrier family 29 member 2 2 2
MIRT501745 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT504995 ZNF652 zinc finger protein 652 2 2
MIRT511664 HIST1H3C histone cluster 1 H3 family member c 2 2
MIRT511690 HIST1H2BO histone cluster 1 H2B family member o 2 4
MIRT511703 HIST1H2BL histone cluster 1 H2B family member l 2 4
MIRT511734 HIST1H2BE histone cluster 1 H2B family member e 2 8
MIRT512858 TBC1D13 TBC1 domain family member 13 2 2
MIRT513444 EMP1 epithelial membrane protein 1 2 6
MIRT515681 TFPI tissue factor pathway inhibitor 2 2
MIRT523529 GLUL glutamate-ammonia ligase 2 2
MIRT525546 PHB2 prohibitin 2 2 4
MIRT526209 SNX24 sorting nexin 24 2 2
MIRT531554 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT533764 TMEM135 transmembrane protein 135 2 2
MIRT545582 SNRPA1 small nuclear ribonucleoprotein polypeptide A' 2 2
MIRT552434 ZNF460 zinc finger protein 460 2 2
MIRT561159 BCL2L12 BCL2 like 12 2 2
MIRT562345 EXOSC2 exosome component 2 2 2
MIRT570659 KDM6B lysine demethylase 6B 2 2
MIRT571076 TCHHL1 trichohyalin like 1 2 2
MIRT571330 TPCN2 two pore segment channel 2 2 2
MIRT571603 TOB2 transducer of ERBB2, 2 2 2
MIRT573013 RPP25 ribonuclease P and MRP subunit p25 2 2
MIRT609041 EP300 E1A binding protein p300 2 2
MIRT613398 DNAH17 dynein axonemal heavy chain 17 2 2
MIRT635589 TTC9C tetratricopeptide repeat domain 9C 2 2
MIRT661118 FPR1 formyl peptide receptor 1 2 2
MIRT690103 PNMA2 paraneoplastic Ma antigen 2 2 2
MIRT694972 PLAC8 placenta specific 8 2 2
MIRT695515 ALPI alkaline phosphatase, intestinal 2 2
MIRT695578 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT699570 SIT1 signaling threshold regulating transmembrane adaptor 1 2 2
MIRT701991 MIER3 MIER family member 3 2 2
MIRT725464 GRAP2 GRB2-related adaptor protein 2 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4481 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-mir-4481 Androstenedione 6128 NSC9563 sensitive cell line (MCF-7)
hsa-mir-4481 Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-4481 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4481 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (cytosolic RNA)
hsa-miR-4481 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4481 Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-4481 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-4481 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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