pre-miRNA Information
pre-miRNA hsa-mir-4436b-1   
Genomic Coordinates chr2: 110086433 - 110086523
Description Homo sapiens miR-4436b-1 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-4436b-2   
Genomic Coordinates chr2: 110284853 - 110284943
Description Homo sapiens miR-4436b-2 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4436b-3p
Sequence 60| CAGGGCAGGAAGAAGUGGACAA |81
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs760150076 9 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol MEX3A   
Synonyms MEX-3A, RKHD4
Description mex-3 RNA binding family member A
Transcript NM_001093725   
Expression
Putative miRNA Targets on MEX3A
3'UTR of MEX3A
(miRNA target sites are highlighted)
>MEX3A|NM_001093725|3'UTR
   1 GCCCCGTGCCCCATGCCTCCGGGGCCCACTCCACTGGGCCCACCCTGGACCTGTTTTCCACTAAAGCCTTTTGGAAAGCG
  81 GTGATTTGAGGGGCAAGGTGCTTAGAGATACTCGCTCGCTGGGGAAGGGGGGAGGGAGGCAGTGGTGGCTGGAGGGTGCG
 161 CCACTTTCAGAGCCTCTGGTCACCCTGTCCTGGAAAGATTGGGAGGGGGCCAGACTGAAAATTTTACTAGAGTTACAACT
 241 CTGATACCTCAACACACCCTTAAATCTGGAAGCAGCTAAGAGAAACTTTTGTTTTGCCAGAGGTGGCCACTAAGGCATTC
 321 TGACGCCCTCTGCCCACCTCCCCCGCTGTGTGTCACTCCACCCCTTCTTCCGAGGAGGGGGTGGGTAAAAGGGAGAGGGA
 401 GAATTACCACCTGTATCTAGAGGTGCTCTTTGCAATCCCTAAGCCCTCTGGTCCTGACCTCCGACCTCCTAACATGACCC
 481 TTTACCTCCCACCCCACCCCCATATCCTGTTTGGGAAACTGTCACCAGTTTCCAGCAGTGTAAGGGAGTTGGAGTCCTAT
 561 CAGAAGTTGCATAGATCTTCTAGGGGTTGGGGAGAGAAGCATGTCAATCGTTTCTGTGGCTGAAAGGCTCAGAAGCCATC
 641 TGTCCCCACAAAGCTGGGCTAGAGGAATCTGGAGAGGAGTCCTCCTCTCTGCCCCTGTCCCCTGCAGTGTTTCCCTTCAC
 721 TCTCTCCGCCTATCTTCCCTTCCTTTGGGATCTTCCCTTTCCTCAACTCTTTCCTTTCCCTCCAGCTCTTTGCTTTGCTT
 801 TCTTTTGGTGGCTGTCACTCCCAGCTCTGTCTTGTTCCTTGTCTTTGTCTTTCTTCCCTTCCCCCTGCCCCTGCCCCTAC
 881 CAGCCCAGCTTTGGGGACACCATCCTTCTGGGGAGAAGTAGGGGGAGGAATATTTGGATGGTCCCTCCATTCCTCTTCAG
 961 GCATCTGGAGGCCCTCTCCCCCACTCCTCCAAAGAAACATCTCAAATTATTGATGGAATGTATCCCCATTCTCAGTGAAA
1041 ATGTGAGGAGGGGACTAATACTGGGGTAAAGGGTCAAACCCCCACCTTCATCACTATGGGCATTATATTTAGGGAGTAGT
1121 TCTTGGGCTGGATTTTCTGGTTGTGGAAGTGGGGGCGCCAGAGTAGTGTGTCTGCTATTTAAAGGAGCAGGAAAGGGCGT
1201 GAGGCAGGAGGAGAGACTGGTGGAGGGAAGAGCTGCTCCTCCCATGCAGTGCCCGACTCCCTGCACCCCTCTCAACCTGA
1281 CCTGAACCTTTATTGAATCCTTATTAGCTTGAATCCTTATTAGCTTGAATCCTCCATGCAAATCATGGAGTCTGTGTCCC
1361 ACCTGATGTGGTTGAGGAGAAGCCAGGTCTTCAAAGAGGGGTCAGCCTGGGGCAAAGCAGGACTGGGGGGAGGTGGGCAG
1441 CAGGGCCTATTCTGAGAATCACATATTGTTACAGGCCTTGCACCCCCTTTGCTGCTTCCCTCCTGCTCATTTGGGGCTGC
1521 CACCAGCTCTCCACCCTCCTGGTTCCGCTGGCCGGGCCAAGAGAGGATGGAGGGATGGGAGTCCCAGGAGATCCTTGTAA
1601 ATAGTGGGGTGGGACTGTTCTGAGTGATCACCCGAGCACTTAAAGCTCCAGAGTCCCATTCTTCCTGGATGGAGCAGGTG
1681 GAGGTGCAGAGGGGATTTCCTCCTCTCCTTCCTCCTGTCGAGAATTAACACCTCTCCACAGCCTTCCCCTCCAGAACACC
1761 AGCCAGGGAGGGGTGGGGAAGGAGGTCACAGCCAAGAAAACTGCCCTGTGACGACTTCCCTCCTTCCCGCCTATGTGAGC
1841 CATCCTGAGATGTCTGTACAATAGAAACCAAACCAAATGGGCACCCTCGGTTGCCGGGGGGCAGGTGGGGAGGGGGGTGG
1921 GAAGAAGGGATGTCTGTCTGTCGTCCCCCTCCCCCTCTCCACTCTTTACCCACAAAGGCAGAAGACTGTTACACTAGGGG
2001 GCTCAGCAAATTCAATCCCACCCTTACCAATTGAGCCAAACCTAGAAACAAACACAAAACACGAATAGTGAGAGACAAAA
2081 TAGAGGAGAGAAAGAGAGCATGAGAGGGAGCGAGACAGGCGACCAACACAGAGGAGAGAAAACAAAAATAGCAAAAAAAA
2161 AAAAAAAAAGCAGTTCTTTATAATTTAATATTCTATTTTAATAAAGGCGTTTATTACCATATAAATGTAGCAAAGAACCT
2241 GGGCTAATATGAAAAAAAAAGACTTTTTATTAGGTAATTTATTATATGAAAAGGATATTTTATTTTATGATAAAGTGATC
2321 CTTAAAAAAATAAAAAAACTTTAGAAGGTTTAGAATATATGTAGGGAGAGAAGAAGAAAAAAATACATTTGTATTCAGAG
2401 TTAAATCTTAAAAAAAAAAAGTGTTTTTAATATATGTTTGGGTTTACGTTGCTTTTTTCCCCCACTTTTTTTTTGGGGAG
2481 GAATGTCATTTGCTTTTCTTGGGGGAGCATCCCGGGGGTGAATGGTGGAGAGAGGAGCTGGGGGAACCCGGTCCCTCCTG
2561 GGACCCTTCCAGTAGATTGGATTTCACTCCATGGACTCCTCCTCCCCTCTCCCCCTCCCCCTCAGGGGAGCCGGCAGAGC
2641 CAAACAAAGAAAGGGATTAACAAGAAAGGAAGAAGCTGTAGGACTAAGGACTGAGGATCCTGGGGTGTCCCCCACCACTT
2721 TCCCCTGCCCTGTCGCAGGGGCAAGTGAGGAGGGGGAATCCAGAATTAAGGCCTAGCAGGCCTATAGGAACCCTCAGAGA
2801 TGTGTGAGATTTAAGAGATCTAGATTTTTTTTTAACCAAAAACAAGAGAGAAAGAGAAGAAAAAGAGAAACCGAGGGGTT
2881 TAAAAGAAAAGAATACTACAAAATAATAATTATTAATAATAATAATTCAAATTTATTTCATATAATCCTAGAGAGAGAAA
2961 GAAACAATTACTAGTTACTTAGTAGACAATATTAAGATAGCTTAAAGTTTAGTAGCATTGAGGGCCCCTGGGTCCAGTAG
3041 AATGTATAAAAGTTGTAAGGAAAAGATAAATAGAGGAGGGAAGTGGCTGAGTCCACCCTGAGTTGCCCAATCTTCAGATA
3121 CCAGGGTTGGATCAGGTTGCTAGTTTAAGATTGGGAGCTTCCAGTCTGCTGGGGTTGATTCTGAGAATCCTTGGATTTTT
3201 AAATTGTAGGACAAAGAAATGAGGGGTTCATTTCCCAGGGTCTTGGAAAGGATGCACACTGATCATCTCAATAAGACAGG
3281 GGCTGGGTTGGGGGCAGCAGAGGAGGCCAAGCACATTCACCTGCACCCCTAGTACCTGGGCAGCCCATACTCCAATGTGG
3361 TATGTCCCCTCCTGGGGCTCCCAGCTCAAACCCTCCCATGCCTGCTTCCCCCAGGCCTAACTGAGGAAGTCCTTCTTGAA
3441 GTGTGACCTCGGTCCACTTCTCTACAGATTGATTTAAGAGCCTGGGAAGTCATTCCACAAACAGACACACATGCACACAC
3521 GCTTCTCACCTTCAGAGCTTCAAGAGCACTGAGGCGATCAGTCCCCTACCCCTGTTCCCATCCAGCTTTCCACTTAGCTT
3601 TGACCTCCATGGCAGCAGTAGCAGTAACAATCTCAGTAATTGTTCTTTAAAGCTGACTCGTTCTTCACCTACTTGCAAAG
3681 TGCTTTCTTGTCTCATAAAAGTTAGATTCCAAGAAGGACTTCCCACGGAGTGGAGTGGAAACACTGTCCTTGAAGGCCTG
3761 GGAGAAAGGCATCCCCATGGGCACAGAGGCTGGGGAAAGGCACAGGGACTTTGGGTGACCCTAACCCTGACCCTCTGCTC
3841 CAGTTCACCTCCATCTATATGTGTTCAGGTAGGGGTCATCTACTGTACCCTGGCCTGGGAACACATTGCCCTCCCCACAC
3921 AAAACTGGAGGGCTTGGCTTCTGCGTGTGAGAAATCAACATTTTTAAAGCACTTGCCTTCTACCAACCCCAGCTTGCAAT
4001 CACTGGGCCTTCCCCTCCTATCCAAGGGGTTGGAGGGGCCCCTTGGCTCTCCTTTTGGCAGGAGGAGCCTGCTTCATTAC
4081 ACCAATGACTCTGCCATCCCCCTCCCTGGCCCTAGACCCCAAACACATCTCCCTCTACCCAATTTACTCTTCTCGCCCCA
4161 CCTAGGGACAGATTCCCCCTGCTCTTTTTGTCCTAGAAACCCCGCTAGTTTGGGATGGTAGCGTCTGGGGTGGGGAGGGC
4241 TTCCCCTTCCCCACTCGAGGGTGCGGGTGGGGAAGGGGGGGTGGGTGGAGACAGCCCTGGGGCAGGGAGGATGGTCTCTC
4321 CACTGTAGAAAGTAGAGTAGGATTGTGGTCAGACTTAATTTGAGGCATCTAGTGAAGACACGTACAAATCCACCAAGGAA
4401 AAAGATTTCAAAAGCAAAATAAAAGCGGGAAATAAAACAGACCCAAGAATAATCAAGTCAAAGTGATGTTGCACAAAATG
4481 CAGAGAAACCAAGAAGGGGGAGGGTTAATGTATTAAATGTGCTATTAAGAACTTAATTTTATTAAAAGTACTATTACTTA
4561 A
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' aacaGGUGAAGAAGGACGGGAc 5'
              ||||||:  |||||||| 
Target 5' cccaCCACTTTCCCCTGCCCTg 3'
2711 - 2732 170.00 -28.80
2
miRNA  3' aacAGGUGAAGAAGGACGGGac 5'
             |:| ||||  |||||||  
Target 5' ttcTTCCCTTCCCCCTGCCCct 3'
851 - 872 147.00 -21.00
3
miRNA  3' aaCAGGUGAAGAAGGACGGGac 5'
            |||| | |||  ||||||  
Target 5' gaGTCCTCCTCT--CTGCCCct 3'
677 - 696 144.00 -18.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31598001 5 COSMIC
COSN30499639 15 COSMIC
COSN30119444 20 COSMIC
COSN18725137 21 COSMIC
COSN30472558 32 COSMIC
COSN30481134 91 COSMIC
COSN7178741 156 COSMIC
COSN31538824 172 COSMIC
COSN1090067 282 COSMIC
COSN28833753 392 COSMIC
COSN31518014 397 COSMIC
COSN31521465 494 COSMIC
COSN32056030 780 COSMIC
COSN26668924 921 COSMIC
COSN31487352 1003 COSMIC
COSN5732233 1093 COSMIC
COSN30173825 1107 COSMIC
COSN28667456 1532 COSMIC
COSN30172263 1620 COSMIC
COSN31532326 1637 COSMIC
COSN8643884 1678 COSMIC
COSN26637627 1828 COSMIC
COSN19679911 1829 COSMIC
COSN26599732 1835 COSMIC
COSN31533905 1889 COSMIC
COSN17279663 1896 COSMIC
COSN26665875 1919 COSMIC
COSN31564639 1943 COSMIC
COSN31526898 2094 COSMIC
COSN26465440 2111 COSMIC
COSN19655419 2143 COSMIC
COSN19655399 2149 COSMIC
COSN27414689 2153 COSMIC
COSN19662834 2170 COSMIC
COSN31529047 2176 COSMIC
COSN31542776 2251 COSMIC
COSN31548796 2289 COSMIC
COSN28756164 2310 COSMIC
COSN27506613 2409 COSMIC
COSN31960322 2453 COSMIC
COSN21910893 2481 COSMIC
COSN31519661 2582 COSMIC
COSN31487112 2632 COSMIC
COSN31607097 2741 COSMIC
COSN31569882 2829 COSMIC
COSN30539328 2834 COSMIC
COSN30539324 2852 COSMIC
COSN8643883 2873 COSMIC
COSN20778067 2891 COSMIC
COSN21609901 2906 COSMIC
COSN31515366 2964 COSMIC
COSN30177181 3020 COSMIC
COSN30158308 3348 COSMIC
COSN28805660 3450 COSMIC
COSN22524993 3467 COSMIC
COSN15660405 3503 COSMIC
COSN20684408 3520 COSMIC
COSN19659580 3853 COSMIC
COSN30542920 3930 COSMIC
COSN25448564 4265 COSMIC
COSN31548363 4290 COSMIC
COSN17075884 4381 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1165101350 1 dbSNP
rs762542951 2 dbSNP
rs772930351 5 dbSNP
rs371739002 6 dbSNP
rs769117344 11 dbSNP
rs747758597 15 dbSNP
rs1455549241 16 dbSNP
rs1263613947 19 dbSNP
rs1164551334 20 dbSNP
rs61813323 24 dbSNP
rs1444929795 25 dbSNP
rs769251732 26 dbSNP
rs952772501 28 dbSNP
rs1228421170 31 dbSNP
rs1366821474 35 dbSNP
rs1387218525 39 dbSNP
rs766178346 42 dbSNP
rs1026953998 44 dbSNP
rs757995309 44 dbSNP
rs1012832848 51 dbSNP
rs1278413980 52 dbSNP
rs895108770 53 dbSNP
rs1212241593 62 dbSNP
rs189315107 65 dbSNP
rs1489127586 79 dbSNP
rs1212149819 80 dbSNP
rs1003408773 82 dbSNP
rs915007744 88 dbSNP
rs906341151 96 dbSNP
rs1474311958 98 dbSNP
rs1162541020 104 dbSNP
rs1349073757 108 dbSNP
rs1458403847 110 dbSNP
rs1042200802 117 dbSNP
rs1382204216 120 dbSNP
rs112037805 128 dbSNP
rs1202084026 132 dbSNP
rs1231062944 136 dbSNP
rs71630613 139 dbSNP
rs1478053664 153 dbSNP
rs1417747870 157 dbSNP
rs1322665699 158 dbSNP
rs144303840 159 dbSNP
rs756811990 160 dbSNP
rs545205901 176 dbSNP
rs1259510770 185 dbSNP
rs1488229055 193 dbSNP
rs1217444197 194 dbSNP
rs750989710 199 dbSNP
rs976728203 210 dbSNP
rs932301682 216 dbSNP
rs1481407531 219 dbSNP
rs921563404 235 dbSNP
rs1424153543 244 dbSNP
rs1166586637 258 dbSNP
rs1362021132 265 dbSNP
rs1418947806 273 dbSNP
rs1202421939 291 dbSNP
rs1361892717 296 dbSNP
rs1412586831 306 dbSNP
rs1379387310 325 dbSNP
rs186421783 327 dbSNP
rs1305227331 328 dbSNP
rs559199955 344 dbSNP
rs541155907 345 dbSNP
rs181998203 354 dbSNP
rs763803120 355 dbSNP
rs757930362 357 dbSNP
rs1209737205 363 dbSNP
rs1334997863 372 dbSNP
rs1484336571 373 dbSNP
rs952803526 374 dbSNP
rs566185482 377 dbSNP
rs189102919 378 dbSNP
rs1439084319 387 dbSNP
rs3738593 392 dbSNP
rs1027096019 405 dbSNP
rs958688161 424 dbSNP
rs1392189892 426 dbSNP
rs1412283038 428 dbSNP
rs1033626441 443 dbSNP
rs1359389069 445 dbSNP
rs1449696536 463 dbSNP
rs1379326494 466 dbSNP
rs1296864901 486 dbSNP
rs1376618367 490 dbSNP
rs543734376 493 dbSNP
rs1057504127 499 dbSNP
rs970642535 500 dbSNP
rs1369361019 502 dbSNP
rs1469319916 506 dbSNP
rs184528562 509 dbSNP
rs760075164 523 dbSNP
rs1314177283 533 dbSNP
rs906118737 554 dbSNP
rs1255964206 556 dbSNP
rs1044515031 559 dbSNP
rs1178968412 571 dbSNP
rs1239980388 574 dbSNP
rs1009363717 581 dbSNP
rs1190141718 587 dbSNP
rs1425246520 591 dbSNP
rs371833582 593 dbSNP
rs893599186 601 dbSNP
rs1168055038 607 dbSNP
rs114516409 610 dbSNP
rs914972025 612 dbSNP
rs539668278 615 dbSNP
rs1348650754 619 dbSNP
rs996542160 626 dbSNP
rs1436313254 627 dbSNP
rs1053495546 638 dbSNP
rs1369781509 640 dbSNP
rs571677349 642 dbSNP
rs1213083418 653 dbSNP
rs1277829288 654 dbSNP
rs139264615 662 dbSNP
rs1441176235 676 dbSNP
rs1199046665 680 dbSNP
rs1259691874 681 dbSNP
rs1449856020 682 dbSNP
rs1220732633 687 dbSNP
rs1246822799 688 dbSNP
rs1240825442 690 dbSNP
rs1040689114 692 dbSNP
rs1190811785 697 dbSNP
rs10047112 703 dbSNP
rs567548043 704 dbSNP
rs1244418529 711 dbSNP
rs549005575 718 dbSNP
rs931476607 720 dbSNP
rs920040670 722 dbSNP
rs192604451 727 dbSNP
rs952553383 728 dbSNP
rs1341382059 734 dbSNP
rs1220685169 740 dbSNP
rs1279935170 745 dbSNP
rs1353949540 749 dbSNP
rs958795067 750 dbSNP
rs1290530323 761 dbSNP
rs928640851 765 dbSNP
rs1453210537 772 dbSNP
rs1213829777 779 dbSNP
rs115646194 780 dbSNP
rs1313241832 782 dbSNP
rs971054668 785 dbSNP
rs961764790 802 dbSNP
rs1367139577 806 dbSNP
rs1020880688 818 dbSNP
rs1009435947 831 dbSNP
rs957843890 837 dbSNP
rs1164158039 839 dbSNP
rs1032116365 855 dbSNP
rs1416597575 861 dbSNP
rs1383697101 862 dbSNP
rs1035664374 869 dbSNP
rs780227098 871 dbSNP
rs1361244459 879 dbSNP
rs1402121405 891 dbSNP
rs1332406301 899 dbSNP
rs996615601 902 dbSNP
rs1447050788 904 dbSNP
rs1284501649 905 dbSNP
rs906093316 909 dbSNP
rs899549117 911 dbSNP
rs1019703837 912 dbSNP
rs1353774990 914 dbSNP
rs35586024 914 dbSNP
rs1218106213 917 dbSNP
rs1011686442 918 dbSNP
rs893337743 934 dbSNP
rs1188701807 939 dbSNP
rs1413857628 940 dbSNP
rs1239569037 941 dbSNP
rs1438464137 944 dbSNP
rs1178539053 947 dbSNP
rs1381026552 948 dbSNP
rs1381050476 953 dbSNP
rs1421614059 958 dbSNP
rs551530918 962 dbSNP
rs1401769027 974 dbSNP
rs1159532203 980 dbSNP
rs147447889 982 dbSNP
rs1383736464 983 dbSNP
rs1162586733 987 dbSNP
rs935056101 1005 dbSNP
rs902268411 1015 dbSNP
rs1240568803 1026 dbSNP
rs1040683374 1033 dbSNP
rs756128726 1035 dbSNP
rs1200677364 1055 dbSNP
rs911129131 1061 dbSNP
rs1190329026 1074 dbSNP
rs985409851 1082 dbSNP
rs1178357923 1094 dbSNP
rs931132181 1104 dbSNP
rs563911870 1114 dbSNP
rs1446384298 1121 dbSNP
rs867486570 1127 dbSNP
rs1442011076 1131 dbSNP
rs1262297876 1132 dbSNP
rs1377126137 1137 dbSNP
rs143740032 1143 dbSNP
rs1478516304 1156 dbSNP
rs1174501694 1157 dbSNP
rs1206790078 1161 dbSNP
rs1350690610 1168 dbSNP
rs931506280 1169 dbSNP
rs1398319831 1175 dbSNP
rs775495593 1177 dbSNP
rs1055861083 1180 dbSNP
rs919718928 1181 dbSNP
rs3814314 1182 dbSNP
rs1290745161 1195 dbSNP
rs928698280 1198 dbSNP
rs981889039 1199 dbSNP
rs1233588063 1200 dbSNP
rs1284826113 1201 dbSNP
rs375182727 1206 dbSNP
rs1286041338 1207 dbSNP
rs1259037460 1212 dbSNP
rs1481939626 1233 dbSNP
rs1225270672 1234 dbSNP
rs1326385414 1238 dbSNP
rs527347171 1245 dbSNP
rs1319598206 1250 dbSNP
rs529026021 1252 dbSNP
rs1201039829 1254 dbSNP
rs138163192 1255 dbSNP
rs1421764043 1255 dbSNP
rs1169771146 1256 dbSNP
rs988037465 1264 dbSNP
rs28402215 1270 dbSNP
rs1364158277 1276 dbSNP
rs981450155 1279 dbSNP
rs1389870864 1282 dbSNP
rs1386871191 1285 dbSNP
rs970059674 1287 dbSNP
rs1032189603 1291 dbSNP
rs975236943 1298 dbSNP
rs1011820676 1299 dbSNP
rs1279304918 1300 dbSNP
rs1424921124 1302 dbSNP
rs12130760 1307 dbSNP
rs1243312895 1307 dbSNP
rs964135627 1315 dbSNP
rs1489055247 1331 dbSNP
rs1035403059 1334 dbSNP
rs999441961 1345 dbSNP
rs902235377 1348 dbSNP
rs1194621951 1351 dbSNP
rs1262232630 1355 dbSNP
rs1430112802 1357 dbSNP
rs1162379610 1358 dbSNP
rs74964948 1363 dbSNP
rs1458293154 1367 dbSNP
rs1008340340 1372 dbSNP
rs889495818 1380 dbSNP
rs1399053982 1382 dbSNP
rs1049426767 1387 dbSNP
rs1363574626 1393 dbSNP
rs1394660330 1406 dbSNP
rs558102761 1425 dbSNP
rs931184391 1426 dbSNP
rs11583438 1427 dbSNP
rs1353053137 1428 dbSNP
rs1217375202 1429 dbSNP
rs1262751868 1431 dbSNP
rs575987703 1434 dbSNP
rs112167407 1437 dbSNP
rs1222875607 1437 dbSNP
rs1255197221 1468 dbSNP
rs1452429303 1470 dbSNP
rs757070793 1472 dbSNP
rs572123560 1475 dbSNP
rs1185311594 1484 dbSNP
rs868250649 1486 dbSNP
rs1418585965 1487 dbSNP
rs937522594 1492 dbSNP
rs1346612932 1505 dbSNP
rs907314602 1511 dbSNP
rs957588994 1525 dbSNP
rs1270831373 1536 dbSNP
rs1307747558 1546 dbSNP
rs1221071253 1547 dbSNP
rs1045800959 1553 dbSNP
rs1032356971 1554 dbSNP
rs999014020 1556 dbSNP
rs946061631 1563 dbSNP
rs1405890883 1567 dbSNP
rs913252128 1574 dbSNP
rs1326506141 1577 dbSNP
rs1205276395 1586 dbSNP
rs1236317008 1597 dbSNP
rs1438945504 1598 dbSNP
rs1019359300 1605 dbSNP
rs1409528100 1617 dbSNP
rs990119564 1620 dbSNP
rs1431136324 1621 dbSNP
rs563985727 1626 dbSNP
rs1406297188 1628 dbSNP
rs1007942056 1633 dbSNP
rs1172113637 1634 dbSNP
rs1415486681 1636 dbSNP
rs1479421842 1652 dbSNP
rs1365537085 1656 dbSNP
rs1428450105 1661 dbSNP
rs1218910212 1662 dbSNP
rs1302272422 1667 dbSNP
rs936578357 1673 dbSNP
rs925149201 1674 dbSNP
rs1325877220 1683 dbSNP
rs975688322 1685 dbSNP
rs1225131532 1686 dbSNP
rs1255904019 1695 dbSNP
rs1457315709 1699 dbSNP
rs1205099755 1705 dbSNP
rs1234163630 1706 dbSNP
rs1230941341 1708 dbSNP
rs1487233795 1711 dbSNP
rs1190085772 1714 dbSNP
rs75319402 1719 dbSNP
rs889548718 1720 dbSNP
rs1423345843 1723 dbSNP
rs1019808066 1729 dbSNP
rs1437457647 1739 dbSNP
rs1411052116 1741 dbSNP
rs1331432267 1744 dbSNP
rs534797535 1745 dbSNP
rs1435888363 1752 dbSNP
rs1258813097 1757 dbSNP
rs995192330 1772 dbSNP
rs1217028929 1783 dbSNP
rs986587434 1785 dbSNP
rs1276117306 1789 dbSNP
rs951107092 1801 dbSNP
rs1025273497 1807 dbSNP
rs561010219 1811 dbSNP
rs567756454 1812 dbSNP
rs1275068148 1813 dbSNP
rs962971052 1813 dbSNP
rs1037386515 1816 dbSNP
rs1319789389 1816 dbSNP
rs1263106660 1827 dbSNP
rs1034599045 1828 dbSNP
rs939860673 1829 dbSNP
rs1262977912 1831 dbSNP
rs928496330 1834 dbSNP
rs1169965740 1835 dbSNP
rs761388475 1836 dbSNP
rs1441036063 1841 dbSNP
rs1045569485 1850 dbSNP
rs1335919667 1862 dbSNP
rs948770657 1869 dbSNP
rs1367496618 1878 dbSNP
rs916008947 1881 dbSNP
rs1297846510 1885 dbSNP
rs555295031 1888 dbSNP
rs1431213018 1895 dbSNP
rs1271661237 1896 dbSNP
rs189850158 1901 dbSNP
rs369754043 1902 dbSNP
rs1291916966 1906 dbSNP
rs1213759835 1907 dbSNP
rs1404677097 1910 dbSNP
rs1284904758 1912 dbSNP
rs1447148785 1913 dbSNP
rs1195798027 1914 dbSNP
rs1177127449 1916 dbSNP
rs1416087170 1918 dbSNP
rs1472782026 1918 dbSNP
rs1184730504 1929 dbSNP
rs1405601606 1932 dbSNP
rs1417975860 1934 dbSNP
rs1158057605 1935 dbSNP
rs1002138635 1942 dbSNP
rs762924007 1943 dbSNP
rs924875003 1944 dbSNP
rs1320116372 1954 dbSNP
rs1469839463 1955 dbSNP
rs1451882956 1957 dbSNP
rs72708253 1967 dbSNP
rs1180712022 1972 dbSNP
rs1237328809 1991 dbSNP
rs1460076078 1993 dbSNP
rs1278385042 1997 dbSNP
rs867896587 1999 dbSNP
rs1206496340 2007 dbSNP
rs1277011176 2013 dbSNP
rs192051988 2017 dbSNP
rs891849738 2018 dbSNP
rs1007746088 2022 dbSNP
rs953754460 2025 dbSNP
rs1438324281 2026 dbSNP
rs1178174054 2031 dbSNP
rs1364447725 2050 dbSNP
rs1314388978 2060 dbSNP
rs1054461282 2062 dbSNP
rs935982321 2063 dbSNP
rs533729380 2080 dbSNP
rs1337071877 2085 dbSNP
rs1408227027 2093 dbSNP
rs1444460363 2099 dbSNP
rs925221120 2099 dbSNP
rs1354006348 2104 dbSNP
rs898187672 2108 dbSNP
rs61525652 2111 dbSNP
rs114242660 2112 dbSNP
rs1240504920 2116 dbSNP
rs1272753074 2120 dbSNP
rs1381478226 2121 dbSNP
rs1336813322 2124 dbSNP
rs1450131075 2127 dbSNP
rs1343314764 2128 dbSNP
rs1158146440 2129 dbSNP
rs1401115538 2131 dbSNP
rs1381914322 2133 dbSNP
rs1160743265 2134 dbSNP
rs1443010274 2135 dbSNP
rs1384694878 2136 dbSNP
rs1182465756 2138 dbSNP
rs953074481 2143 dbSNP
rs1240820329 2145 dbSNP
rs1028616221 2149 dbSNP
rs1233139040 2151 dbSNP
rs1268681661 2151 dbSNP
rs1010813189 2152 dbSNP
rs1467521995 2153 dbSNP
rs907123777 2157 dbSNP
rs1377287342 2159 dbSNP
rs1288584375 2162 dbSNP
rs1176964761 2164 dbSNP
rs1431115169 2167 dbSNP
rs1167285268 2170 dbSNP
rs1319154371 2170 dbSNP
rs1464043475 2170 dbSNP
rs201492514 2170 dbSNP
rs879118445 2170 dbSNP
rs1243401662 2171 dbSNP
rs1285634073 2172 dbSNP
rs1358200744 2174 dbSNP
rs1227092962 2187 dbSNP
rs1045511256 2188 dbSNP
rs1342005828 2189 dbSNP
rs1208148789 2204 dbSNP
rs1039606649 2208 dbSNP
rs1490594065 2209 dbSNP
rs1201829325 2210 dbSNP
rs1261239500 2216 dbSNP
rs528935783 2225 dbSNP
rs1229498781 2228 dbSNP
rs1476735790 2234 dbSNP
rs1359217725 2242 dbSNP
rs893691212 2249 dbSNP
rs915977924 2250 dbSNP
rs1463447548 2257 dbSNP
rs1054498093 2260 dbSNP
rs1304610444 2261 dbSNP
rs1364368269 2261 dbSNP
rs1424959090 2261 dbSNP
rs942591496 2264 dbSNP
rs1382016725 2266 dbSNP
rs1296669034 2269 dbSNP
rs765081837 2276 dbSNP
rs936001142 2285 dbSNP
rs912412489 2287 dbSNP
rs1291193827 2294 dbSNP
rs1300994117 2313 dbSNP
rs924567888 2315 dbSNP
rs112079677 2334 dbSNP
rs977458241 2339 dbSNP
rs987004695 2342 dbSNP
rs944924796 2364 dbSNP
rs1262158728 2379 dbSNP
rs79273244 2383 dbSNP
rs1181659977 2384 dbSNP
rs1430275579 2384 dbSNP
rs759272894 2384 dbSNP
rs78284262 2386 dbSNP
rs951137260 2402 dbSNP
rs918333956 2404 dbSNP
rs1365141535 2406 dbSNP
rs1165609082 2410 dbSNP
rs558262974 2421 dbSNP
rs953557426 2421 dbSNP
rs973743986 2421 dbSNP
rs1452592861 2425 dbSNP
rs1289887386 2437 dbSNP
rs1387555466 2439 dbSNP
rs962340462 2447 dbSNP
rs1315004854 2448 dbSNP
rs1384091937 2459 dbSNP
rs1248278048 2464 dbSNP
rs1307159228 2467 dbSNP
rs1316620383 2468 dbSNP
rs1035036733 2470 dbSNP
rs1001812316 2473 dbSNP
rs561790868 2474 dbSNP
rs962491944 2475 dbSNP
rs549771546 2481 dbSNP
rs776124770 2484 dbSNP
rs1024482832 2485 dbSNP
rs535231763 2511 dbSNP
rs1003894152 2513 dbSNP
rs758137287 2514 dbSNP
rs1365140698 2516 dbSNP
rs1336417867 2520 dbSNP
rs1407543065 2523 dbSNP
rs1265798558 2530 dbSNP
rs1054534003 2535 dbSNP
rs1372668418 2539 dbSNP
rs1220644097 2544 dbSNP
rs1000222586 2548 dbSNP
rs1310597596 2549 dbSNP
rs796814958 2550 dbSNP
rs1461766855 2553 dbSNP
rs894346512 2555 dbSNP
rs1230726794 2557 dbSNP
rs1039419907 2558 dbSNP
rs1223285688 2564 dbSNP
rs942641895 2587 dbSNP
rs912429666 2594 dbSNP
rs1054220332 2600 dbSNP
rs936050379 2606 dbSNP
rs141288533 2609 dbSNP
rs1294232885 2611 dbSNP
rs1176240329 2615 dbSNP
rs1430378853 2617 dbSNP
rs1471268852 2620 dbSNP
rs1219181662 2621 dbSNP
rs1042088526 2623 dbSNP
rs944749869 2626 dbSNP
rs368093549 2628 dbSNP
rs1299908174 2632 dbSNP
rs912118450 2633 dbSNP
rs752312808 2639 dbSNP
rs1323963228 2649 dbSNP
rs779297170 2651 dbSNP
rs986417561 2653 dbSNP
rs1306789252 2654 dbSNP
rs932133164 2655 dbSNP
rs572420096 2661 dbSNP
rs1404063931 2662 dbSNP
rs962413304 2664 dbSNP
rs973574968 2675 dbSNP
rs1481643740 2676 dbSNP
rs755358935 2681 dbSNP
rs1185080609 2682 dbSNP
rs78447160 2683 dbSNP
rs772643780 2692 dbSNP
rs1172709109 2703 dbSNP
rs1169748285 2709 dbSNP
rs1466612100 2710 dbSNP
rs1424318122 2711 dbSNP
rs374411342 2717 dbSNP
rs1347546682 2719 dbSNP
rs1406559039 2723 dbSNP
rs1268182795 2729 dbSNP
rs971115727 2731 dbSNP
rs1197857316 2734 dbSNP
rs777186825 2735 dbSNP
rs187530724 2739 dbSNP
rs956176834 2740 dbSNP
rs3178587 2747 dbSNP
rs542009156 2753 dbSNP
rs1012748128 2763 dbSNP
rs574022876 2771 dbSNP
rs866637357 2772 dbSNP
rs544374528 2776 dbSNP
rs1214169841 2778 dbSNP
rs1241890230 2783 dbSNP
rs766914785 2790 dbSNP
rs1188780621 2797 dbSNP
rs1000296361 2802 dbSNP
rs1444118059 2804 dbSNP
rs1032780143 2820 dbSNP
rs900552642 2823 dbSNP
rs1000052361 2834 dbSNP
rs1399170251 2834 dbSNP
rs1055801 2843 dbSNP
rs1041836183 2846 dbSNP
rs1055803 2846 dbSNP
rs903249562 2846 dbSNP
rs1055804 2848 dbSNP
rs1055805 2850 dbSNP
rs1344360156 2852 dbSNP
rs1198673416 2854 dbSNP
rs1319959809 2856 dbSNP
rs1431129126 2858 dbSNP
rs1261220844 2859 dbSNP
rs1017607590 2872 dbSNP
rs1331522433 2873 dbSNP
rs1244625632 2877 dbSNP
rs1315124641 2886 dbSNP
rs944699475 2892 dbSNP
rs1202974608 2894 dbSNP
rs890502337 2895 dbSNP
rs1447960424 2896 dbSNP
rs1218337028 2899 dbSNP
rs1303124164 2904 dbSNP
rs1009310944 2911 dbSNP
rs1388747732 2911 dbSNP
rs761030757 2912 dbSNP
rs1387131579 2913 dbSNP
rs1050417643 2916 dbSNP
rs1158232570 2918 dbSNP
rs1408930783 2919 dbSNP
rs1401076340 2921 dbSNP
rs932185383 2927 dbSNP
rs891079488 2933 dbSNP
rs113303894 2953 dbSNP
rs1336867446 2959 dbSNP
rs576024408 2974 dbSNP
rs1236194603 2979 dbSNP
rs1278623364 2982 dbSNP
rs1402525334 2989 dbSNP
rs1230686947 2996 dbSNP
rs940891644 2998 dbSNP
rs1323497782 3000 dbSNP
rs1204838657 3004 dbSNP
rs1245453681 3007 dbSNP
rs775618188 3013 dbSNP
rs929834793 3018 dbSNP
rs535826753 3022 dbSNP
rs1378583410 3023 dbSNP
rs1178618594 3025 dbSNP
rs1038139335 3033 dbSNP
rs971467910 3039 dbSNP
rs941125813 3042 dbSNP
rs926993601 3043 dbSNP
rs557771899 3047 dbSNP
rs958593646 3058 dbSNP
rs1178829200 3067 dbSNP
rs949741763 3070 dbSNP
rs917534493 3071 dbSNP
rs539704981 3072 dbSNP
rs1240708713 3083 dbSNP
rs1032915952 3084 dbSNP
rs1203029673 3100 dbSNP
rs1345545407 3107 dbSNP
rs370249011 3110 dbSNP
rs1236551712 3122 dbSNP
rs1273805275 3126 dbSNP
rs1315383741 3127 dbSNP
rs1439821090 3130 dbSNP
rs967272842 3152 dbSNP
rs1020787900 3167 dbSNP
rs1008942003 3181 dbSNP
rs1199796679 3189 dbSNP
rs890549804 3191 dbSNP
rs1460398841 3197 dbSNP
rs1280524221 3211 dbSNP
rs1166848645 3217 dbSNP
rs569978224 3225 dbSNP
rs1396562434 3228 dbSNP
rs1431052099 3233 dbSNP
rs1300932928 3234 dbSNP
rs1344401438 3242 dbSNP
rs1050388325 3245 dbSNP
rs956250460 3249 dbSNP
rs1303849042 3260 dbSNP
rs566369150 3266 dbSNP
rs1325277555 3271 dbSNP
rs996196661 3278 dbSNP
rs899396575 3279 dbSNP
rs1037984165 3280 dbSNP
rs1291326792 3285 dbSNP
rs1241135649 3286 dbSNP
rs1379297873 3287 dbSNP
rs148243147 3291 dbSNP
rs1269163213 3300 dbSNP
rs1426710675 3315 dbSNP
rs369724468 3321 dbSNP
rs1334704907 3339 dbSNP
rs796868669 3350 dbSNP
rs1373529129 3351 dbSNP
rs964862720 3355 dbSNP
rs1161063462 3356 dbSNP
rs143095385 3356 dbSNP
rs1410443786 3359 dbSNP
rs1295697446 3371 dbSNP
rs1383238627 3374 dbSNP
rs1381965725 3375 dbSNP
rs917016141 3380 dbSNP
rs1403478192 3390 dbSNP
rs767494099 3392 dbSNP
rs1243890784 3397 dbSNP
rs568707685 3399 dbSNP
rs1026249144 3404 dbSNP
rs994057887 3431 dbSNP
rs550172953 3434 dbSNP
rs1158933223 3438 dbSNP
rs1484788373 3438 dbSNP
rs1441148341 3446 dbSNP
rs11264432 3450 dbSNP
rs114949117 3451 dbSNP
rs941186005 3453 dbSNP
rs1466186904 3460 dbSNP
rs978743281 3467 dbSNP
rs1442957462 3480 dbSNP
rs564060182 3481 dbSNP
rs1166505645 3483 dbSNP
rs1044523572 3485 dbSNP
rs35341982 3487 dbSNP
rs1361665654 3506 dbSNP
rs967703997 3509 dbSNP
rs554355148 3512 dbSNP
rs1391546252 3513 dbSNP
rs1451055735 3516 dbSNP
rs1286466271 3520 dbSNP
rs183163151 3521 dbSNP
rs776227570 3523 dbSNP
rs77292424 3535 dbSNP
rs1244109994 3542 dbSNP
rs1340140296 3548 dbSNP
rs1341111951 3554 dbSNP
rs996164305 3555 dbSNP
rs73004954 3556 dbSNP
rs1242405396 3564 dbSNP
rs1378346058 3566 dbSNP
rs1483311139 3566 dbSNP
rs1183031640 3571 dbSNP
rs1247996352 3572 dbSNP
rs1381006403 3580 dbSNP
rs1160460947 3590 dbSNP
rs1414620075 3599 dbSNP
rs1360361813 3601 dbSNP
rs934904905 3604 dbSNP
rs1005095520 3609 dbSNP
rs926190524 3612 dbSNP
rs187487815 3615 dbSNP
rs978959874 3622 dbSNP
rs574553150 3632 dbSNP
rs965231283 3636 dbSNP
rs910662533 3637 dbSNP
rs547144975 3638 dbSNP
rs1363276317 3644 dbSNP
rs562390758 3645 dbSNP
rs1288807471 3653 dbSNP
rs1162161009 3659 dbSNP
rs1472863136 3660 dbSNP
rs1369681710 3666 dbSNP
rs895556841 3671 dbSNP
rs1211693479 3678 dbSNP
rs1249111183 3701 dbSNP
rs1480133565 3702 dbSNP
rs987977732 3705 dbSNP
rs770959323 3707 dbSNP
rs1209777657 3710 dbSNP
rs746916063 3722 dbSNP
rs768874331 3726 dbSNP
rs527521303 3727 dbSNP
rs1353992871 3732 dbSNP
rs1430435020 3733 dbSNP
rs1310126956 3734 dbSNP
rs1218462037 3738 dbSNP
rs1489414219 3739 dbSNP
rs925604908 3744 dbSNP
rs371476568 3745 dbSNP
rs978844363 3748 dbSNP
rs780129219 3749 dbSNP
rs945954503 3762 dbSNP
rs771547251 3784 dbSNP
rs913157465 3786 dbSNP
rs993419776 3798 dbSNP
rs954555024 3807 dbSNP
rs747610276 3812 dbSNP
rs1340388472 3819 dbSNP
rs1016797989 3825 dbSNP
rs1247621739 3826 dbSNP
rs567797227 3830 dbSNP
rs1016237231 3833 dbSNP
rs1419381737 3836 dbSNP
rs1005312123 3846 dbSNP
rs576139191 3848 dbSNP
rs886676456 3857 dbSNP
rs867647462 3863 dbSNP
rs557685809 3871 dbSNP
rs138794526 3876 dbSNP
rs1350274195 3885 dbSNP
rs1438298081 3887 dbSNP
rs754558617 3907 dbSNP
rs754216474 3909 dbSNP
rs374832927 3911 dbSNP
rs1228569811 3916 dbSNP
rs1299167160 3930 dbSNP
rs1052809997 3937 dbSNP
rs1392266968 3938 dbSNP
rs112621070 3945 dbSNP
rs554433982 3955 dbSNP
rs1244758299 3956 dbSNP
rs1465063351 3957 dbSNP
rs535797787 3961 dbSNP
rs1290088579 3966 dbSNP
rs770974070 3969 dbSNP
rs1424206913 3976 dbSNP
rs1453719280 3984 dbSNP
rs926223020 3997 dbSNP
rs756715453 4001 dbSNP
rs1479363693 4012 dbSNP
rs1245895829 4014 dbSNP
rs1198503688 4015 dbSNP
rs182945688 4016 dbSNP
rs945724573 4019 dbSNP
rs1444291933 4030 dbSNP
rs1043684569 4042 dbSNP
rs1416142882 4043 dbSNP
rs1406890524 4055 dbSNP
rs913133430 4058 dbSNP
rs943608598 4060 dbSNP
rs910722539 4064 dbSNP
rs921722977 4066 dbSNP
rs1259314876 4089 dbSNP
rs1220978194 4093 dbSNP
rs987622552 4102 dbSNP
rs1284433420 4122 dbSNP
rs1357959306 4124 dbSNP
rs1222481918 4125 dbSNP
rs1274562396 4133 dbSNP
rs1284001980 4135 dbSNP
rs1436770565 4140 dbSNP
rs1211104534 4149 dbSNP
rs745955302 4154 dbSNP
rs963471262 4155 dbSNP
rs1016784785 4166 dbSNP
rs750866969 4167 dbSNP
rs919336838 4173 dbSNP
rs191005373 4175 dbSNP
rs796752484 4176 dbSNP
rs1457527574 4177 dbSNP
rs1013752905 4192 dbSNP
rs895412671 4199 dbSNP
rs1334236998 4201 dbSNP
rs537898418 4203 dbSNP
rs570563363 4204 dbSNP
rs1351515523 4205 dbSNP
rs1043226043 4222 dbSNP
rs762012431 4223 dbSNP
rs1248629516 4243 dbSNP
rs1023225508 4245 dbSNP
rs531457316 4248 dbSNP
rs895602129 4256 dbSNP
rs551858507 4257 dbSNP
rs1457409485 4264 dbSNP
rs1052843246 4265 dbSNP
rs1477654789 4266 dbSNP
rs1201078435 4268 dbSNP
rs1403695577 4274 dbSNP
rs527296240 4274 dbSNP
rs566378661 4276 dbSNP
rs904208424 4277 dbSNP
rs1220141267 4280 dbSNP
rs1277067358 4282 dbSNP
rs1337564196 4282 dbSNP
rs143552199 4282 dbSNP
rs1204444839 4285 dbSNP
rs34076892 4286 dbSNP
rs1275642572 4299 dbSNP
rs1277465509 4300 dbSNP
rs1207116764 4302 dbSNP
rs1238963909 4310 dbSNP
rs1266474203 4311 dbSNP
rs751620690 4314 dbSNP
rs1038868618 4321 dbSNP
rs941887486 4326 dbSNP
rs1167397770 4329 dbSNP
rs909292367 4335 dbSNP
rs1431216124 4337 dbSNP
rs186607460 4345 dbSNP
rs1390492603 4350 dbSNP
rs1334604081 4354 dbSNP
rs1387665501 4368 dbSNP
rs1326112377 4371 dbSNP
rs1042698943 4379 dbSNP
rs764421615 4381 dbSNP
rs529977552 4382 dbSNP
rs1344637122 4390 dbSNP
rs1244030764 4393 dbSNP
rs1265037815 4395 dbSNP
rs917885188 4404 dbSNP
rs1210151986 4419 dbSNP
rs182829057 4426 dbSNP
rs763251487 4427 dbSNP
rs776555478 4445 dbSNP
rs1052402570 4452 dbSNP
rs1237456236 4457 dbSNP
rs1211416451 4459 dbSNP
rs1444555277 4466 dbSNP
rs933479758 4467 dbSNP
rs536873415 4468 dbSNP
rs972103393 4475 dbSNP
rs1215444140 4479 dbSNP
rs1353898548 4480 dbSNP
rs1165352300 4483 dbSNP
rs1033915055 4497 dbSNP
rs942091656 4504 dbSNP
rs544006528 4512 dbSNP
rs1434972286 4519 dbSNP
rs1001027043 4521 dbSNP
rs1367472281 4530 dbSNP
rs909214869 4538 dbSNP
rs980759260 4548 dbSNP
rs1450494500 4551 dbSNP
rs1226076398 4553 dbSNP
rs968654584 4555 dbSNP
rs1377768874 4561 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' aacaGGUGAAGAAGGACGGGAc 5'
              ||||  ||  :| |||| 
Target 5' ----CCACCACU--UUCCCCUg 3'
1 - 16
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000532414.2 | 3UTR | CCACCACUUUCCCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
87 hsa-miR-4436b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066957 ATXN7L3B ataxin 7 like 3B 2 8
MIRT119284 NABP1 nucleic acid binding protein 1 2 6
MIRT128915 KMT2A lysine methyltransferase 2A 2 2
MIRT150116 MIDN midnolin 2 2
MIRT173040 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT253117 BCL2L12 BCL2 like 12 2 2
MIRT256997 RGMB repulsive guidance molecule family member b 2 2
MIRT259746 SNX12 sorting nexin 12 2 2
MIRT267278 TMEM109 transmembrane protein 109 2 2
MIRT441934 C1orf109 chromosome 1 open reading frame 109 2 2
MIRT443625 CPSF2 cleavage and polyadenylation specific factor 2 2 2
MIRT445757 AGO1 argonaute 1, RISC catalytic component 2 2
MIRT447835 CTIF cap binding complex dependent translation initiation factor 2 2
MIRT451230 ZNF444 zinc finger protein 444 2 2
MIRT451966 TMPRSS5 transmembrane protease, serine 5 2 2
MIRT453127 HOXC4 homeobox C4 2 2
MIRT454604 RPL13A ribosomal protein L13a 2 2
MIRT455176 SUV39H1 suppressor of variegation 3-9 homolog 1 2 2
MIRT455547 GJB1 gap junction protein beta 1 2 2
MIRT458197 ATP6V0A2 ATPase H+ transporting V0 subunit a2 2 2
MIRT458356 NOC2L NOC2 like nucleolar associated transcriptional repressor 2 2
MIRT458923 DNM2 dynamin 2 2 2
MIRT461013 SYT7 synaptotagmin 7 2 2
MIRT461643 ZSWIM4 zinc finger SWIM-type containing 4 2 2
MIRT461997 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT462367 BCL7B BCL tumor suppressor 7B 2 2
MIRT464915 TXNIP thioredoxin interacting protein 2 2
MIRT466311 TIMM22 translocase of inner mitochondrial membrane 22 2 2
MIRT466591 TBC1D2B TBC1 domain family member 2B 2 2
MIRT467045 SRSF1 serine and arginine rich splicing factor 1 2 2
MIRT468750 SDC2 syndecan 2 2 2
MIRT468943 RPS24 ribosomal protein S24 2 2
MIRT469474 REEP5 receptor accessory protein 5 2 2
MIRT469913 PTRF caveolae associated protein 1 2 2
MIRT473325 MEX3A mex-3 RNA binding family member A 2 2
MIRT473643 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT474064 LMNB2 lamin B2 2 2
MIRT474357 KMT2D lysine methyltransferase 2D 2 2
MIRT475394 ICMT isoprenylcysteine carboxyl methyltransferase 2 4
MIRT476335 GLTSCR1L BRD4 interacting chromatin remodeling complex associated protein like 2 2
MIRT478651 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT479585 CDC42SE1 CDC42 small effector 1 2 2
MIRT479943 CBX5 chromobox 5 2 2
MIRT482001 AMOTL2 angiomotin like 2 2 2
MIRT482043 AMER1 APC membrane recruitment protein 1 2 2
MIRT483070 EXT2 exostosin glycosyltransferase 2 2 6
MIRT484323 KCNH1 potassium voltage-gated channel subfamily H member 1 2 4
MIRT487528 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT489636 ALS2CL ALS2 C-terminal like 2 2
MIRT490693 SSTR1 somatostatin receptor 1 2 2
MIRT490871 UPK2 uroplakin 2 2 2
MIRT492582 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT492945 NEUROD2 neuronal differentiation 2 2 2
MIRT498675 SOD2 superoxide dismutase 2 2 4
MIRT499349 RAB25 RAB25, member RAS oncogene family 2 2
MIRT502338 GIGYF1 GRB10 interacting GYF protein 1 2 4
MIRT502976 CCNL1 cyclin L1 2 8
MIRT503706 NUP62 nucleoporin 62 2 2
MIRT505567 SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 2 2
MIRT507808 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT513242 FBXO41 F-box protein 41 2 6
MIRT513586 EVX1 even-skipped homeobox 1 2 2
MIRT525036 FRK fyn related Src family tyrosine kinase 2 2
MIRT531035 TDGF1P3 teratocarcinoma-derived growth factor 1 pseudogene 3 2 2
MIRT531939 RBMS2 RNA binding motif single stranded interacting protein 2 2 2
MIRT534912 PUM2 pumilio RNA binding family member 2 2 2
MIRT535717 N4BP1 NEDD4 binding protein 1 2 2
MIRT540498 ZMAT4 zinc finger matrin-type 4 2 4
MIRT541465 AURKA aurora kinase A 2 2
MIRT554328 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT561572 SLC6A9 solute carrier family 6 member 9 2 2
MIRT564715 ZNF322P1 zinc finger protein 322 pseudogene 1 2 2
MIRT576176 Hmox1 heme oxygenase 1 2 2
MIRT629712 XKR4 XK related 4 2 2
MIRT636182 THBD thrombomodulin 2 2
MIRT646315 MPHOSPH8 M-phase phosphoprotein 8 2 2
MIRT649174 IQSEC1 IQ motif and Sec7 domain 1 2 2
MIRT666945 PMEPA1 prostate transmembrane protein, androgen induced 1 2 2
MIRT684057 FOLR1 folate receptor 1 2 2
MIRT687585 MAU2 MAU2 sister chromatid cohesion factor 2 2
MIRT689953 ZNF185 zinc finger protein 185 with LIM domain 2 2
MIRT704071 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT704327 DCUN1D5 defective in cullin neddylation 1 domain containing 5 2 2
MIRT705406 ATP1B3 ATPase Na+/K+ transporting subunit beta 3 2 2
MIRT710488 CDH5 cadherin 5 2 2
MIRT718241 LCE1A late cornified envelope 1A 2 2
MIRT723182 CDCA4 cell division cycle associated 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4436b-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-4436b-3p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

Error report submission