miRTarBase - #MIRT473608


—
pre-miRNA Information
pre-miRNA hsa-mir-6132   
Genomic Coordinates chr7: 117020211 - 117020319
Description Homo sapiens miR-6132 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6132
Sequence 21| AGCAGGGCUGGGGAUUGCA |39
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1272646274 4 dbSNP
rs1211969145 8 dbSNP
rs1310278496 11 dbSNP
rs1044115534 13 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol MARK2   
Synonyms EMK-1, EMK1, PAR-1, Par-1b, Par1b
Description microtubule affinity regulating kinase 2
Transcript NM_001039469   
Other Transcripts NM_001163296 , NM_001163297 , NM_004954 , NM_017490   
Expression
Putative miRNA Targets on MARK2
3'UTR of MARK2
(miRNA target sites are highlighted)		 
>MARK2|NM_001039469|3'UTR
   1 CAGGCTGCCAGGAGCGGGGGCGGCGGGGGCGGGCCAGCTGGACGGGCTGCCGGCCGCTGCGCCGCCCCACCTGGGCGAGA
  81 CTGCAGCGATGGATTGGTGTGTCTCCCCTGCTGGCACTTCTCCCCTCCCTGGCCCTTCTCAGTTTTCTCTTACATGTTTG
 161 TGGGGGGTGGGAGATTGTTCTCCAGCACCCCACATTCACCCCTGCCCAGAGATTCCCCCTTCTCCTCTCCCCTACTGGAG
 241 GCAAAGGAAGGGGAGGGTGGATGGGGGGGCAGGGCTCCCCCTCGGTACTGCGGTTGCACAGAGTATTTCGCCTAAACCAA
 321 GAAATTTTTTATTACCAAAAAGAAAAAAGAAAAAAAAAATCCCAGCGGCCACCTTTCCTCCCTGCCCCATTGGGACAGTC
 401 GAGACTGGATCTGTGGGGTTTCCCGGGAGGGTGGCTCAGGGCTGGAACACTCTCAGGCAAGAGTGGTGGAGCTCCCGTCA
 481 GGCCCTCCGCCAGGCCCACTGTGGGCTTCTCCCCTCTCCTCCCTCCTTCCCCTCCAAGCAAACCACCAGAGGTGGCCTTC
 561 CCCTGACCTCAGGCCCCTGGGCTGGAGGCCTGGGCGGTGGGGCAGGGGGCGGGGGTGCTGCGCAGCCCTGCAGTGGGTGG
 641 GGCTGGGGGCTGCTCCGGGGCTGCTGAGGCTGGAGGGCCGGCACAAGGCTCCGCCTCCCTCCACACTGTACCCTCTGCCC
 721 CTCCTCCCCAGAGCTGGGCATTTCCTTCCACAAGCTGCTGTGGGGACGTGTGTTCCCTCAAAGTCTGTGCCATCTTCTCC
 801 CACCCCTCCCGGGTAGAAGGAGGGGCTGACCCCAGGGCTGGGAGAGGGGAGGGGACTGGAGGGCAGACTGGCTTCTCGGT
 881 CCCCAGGGGGCCGCTTGGGCTGTTGGTCTCCAGAGCAGGGCCACTGGGCACTCTGTGATGGGGGAGCCTTTGTCTGAAAG
 961 CACAGCCCCCTCGCCCTTCCTCTCCCCATGGCTTCCCCTTCATTGGCATTAATCTGGGCACCAGCTCTCTCCATAGCAGT
1041 GACTTCCCTCACCACTCTCATCTCTCAGCCTTGCCTTTTCTTCCTGACACTGTCGCCCCCTCCTCTCAGGAGACACTGCC
1121 GAGGGCCACCTGGCAGAAGGCTGAGTTAGGCAGCAGGGCCGGGAGCGTCTGCCCTCCACAGGGTGGGGGACAGATAGGCT
1201 AAGCGACTCCCAGCTTGCTACCCTCAGTGGCCAGTGTGGGCGTGGGCGGTTTGGGGCGCTTGGCTGGTGGTGGCCACTGC
1281 ATCCCTTAATTTATTTCTCTGCTGTTTCTGTTCTTGAGAAATTGGGGGTGGGAGTCCTACACAGAGGCTGCCCCTACCCT
1361 CACCTGAGTTGTACATTTTTTTGTGATGGGTTTTATTTTTTATTATTTTATTTTATTTTTTTTTTTTTTGATTTATGATG
1441 ACTCCACCCCTCTTCATCACCCCCGCTCCCAGGCCAGGCTCAGCGATTAAGCCGAGCCCTTGCGTCCTAGGAAGGGGCCT
1521 TGCCAACCTCAGCCCTCCTGCCCCACACTCCTACTGCGGCTCAGACCAAGGGCTCCCCCTCCCTCCCTTCCCCCCTCCTG
1601 CCCTATGGAACAGCCCGGGTGCTCTGAGGGGGCTGGGAGGGCATGGCTTGGCTCCCAAAGGGGGTAGGGGCCCGGGGCAC
1681 CCAGGCAAGGTGGCCCCTCCCCGTCTAGCCCCCTCCTCCCCAACCCTGCACTTAGTTTCTCCTCTGGATCAAACACGTAA
1761 TAAAGAGAATGTTTGGAATCTGAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acguuAGGGGUCGGGACGa 5'
               | | ||||||||| 
Target 5' ggtgcTGCGCAGCCCTGCa 3'
 614 - 632 154.00 -20.20
2 
miRNA  3' acguUAG-GGGUCGGGACGa 5'
              ||| |:|||||:||| 
Target 5' tctcATCTCTCAGCCTTGCc 3'
 1056 - 1075 147.00 -20.70
3 
miRNA  3' acguuAGGGGUCGGGACGa 5'
               |||||| |||||| 
Target 5' cctccTCCCCAACCCTGCa 3'
 1712 - 1730 138.00 -21.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26983791 16 COSMIC
COSN13338465 22 COSMIC
COSN20077435 23 COSMIC
COSN18736200 53 COSMIC
COSN30502810 57 COSMIC
COSN26983792 61 COSMIC
COSN31603280 62 COSMIC
COSN17431269 73 COSMIC
COSN1135977 74 COSMIC
COSN31578788 107 COSMIC
COSN31549738 143 COSMIC
COSN31487246 212 COSMIC
COSN29652050 360 COSMIC
COSN31561870 401 COSMIC
COSN30545211 464 COSMIC
COSN25661712 619 COSMIC
COSN23518629 821 COSMIC
COSN23792848 1177 COSMIC
COSN20108363 1420 COSMIC
COSN1135979 1432 COSMIC
COSN8687491 1465 COSMIC
COSN21806729 1531 COSMIC
COSN8282550 1615 COSMIC
COSN29687626 1616 COSMIC
COSN24557918 1723 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs762507971 2 dbSNP
rs540924870 11 dbSNP
rs1259823586 12 dbSNP
rs1483369464 13 dbSNP
rs1480369748 14 dbSNP
rs779914213 14 dbSNP
rs751502016 15 dbSNP
rs756987099 16 dbSNP
rs780868528 17 dbSNP
rs963759863 19 dbSNP
rs1357917836 20 dbSNP
rs756255557 21 dbSNP
rs372628143 22 dbSNP
rs749327913 23 dbSNP
rs768864536 25 dbSNP
rs1360027698 26 dbSNP
rs779507575 28 dbSNP
rs1016076928 31 dbSNP
rs1375173985 32 dbSNP
rs748690423 37 dbSNP
rs1241346306 38 dbSNP
rs1379515683 39 dbSNP
rs772526433 44 dbSNP
rs773419063 45 dbSNP
rs1371767519 46 dbSNP
rs1221639640 47 dbSNP
rs1305655922 49 dbSNP
rs1312423045 52 dbSNP
rs924036657 53 dbSNP
rs1408787517 54 dbSNP
rs1441342524 54 dbSNP
rs1378212667 56 dbSNP
rs1394591561 57 dbSNP
rs935316010 61 dbSNP
rs539595398 62 dbSNP
rs1053813287 65 dbSNP
rs987714841 68 dbSNP
rs915161552 69 dbSNP
rs1217943269 71 dbSNP
rs1320579447 75 dbSNP
rs912129136 77 dbSNP
rs1356341603 85 dbSNP
rs1278128882 89 dbSNP
rs1237957055 93 dbSNP
rs760419346 94 dbSNP
rs1302873084 98 dbSNP
rs560808565 101 dbSNP
rs1364360350 112 dbSNP
rs1317336330 117 dbSNP
rs1298772781 121 dbSNP
rs974855034 122 dbSNP
rs369497487 123 dbSNP
rs879666923 125 dbSNP
rs1157778729 130 dbSNP
rs1042134860 132 dbSNP
rs1378437073 133 dbSNP
rs902209358 135 dbSNP
rs1268229729 136 dbSNP
rs757298550 137 dbSNP
rs890258374 150 dbSNP
rs1009165516 154 dbSNP
rs1204924159 162 dbSNP
rs1282682268 162 dbSNP
rs879400899 163 dbSNP
rs1056418146 165 dbSNP
rs895039259 167 dbSNP
rs1278262095 168 dbSNP
rs1401840635 169 dbSNP
rs1012099458 183 dbSNP
rs1190926133 185 dbSNP
rs182664 188 dbSNP
rs1404038481 206 dbSNP
rs1178902553 208 dbSNP
rs1468411944 213 dbSNP
rs1480449645 215 dbSNP
rs1428758365 216 dbSNP
rs1171476184 217 dbSNP
rs994496321 219 dbSNP
rs1027315249 222 dbSNP
rs1443393015 224 dbSNP
rs542210682 231 dbSNP
rs1017141003 232 dbSNP
rs192906403 235 dbSNP
rs781228106 237 dbSNP
rs1386369652 238 dbSNP
rs1258226744 241 dbSNP
rs1219947430 243 dbSNP
rs1336822882 251 dbSNP
rs1269556694 255 dbSNP
rs952956558 255 dbSNP
rs1012419332 263 dbSNP
rs1342094613 263 dbSNP
rs1450819040 263 dbSNP
rs531271423 264 dbSNP
rs1405632608 265 dbSNP
rs1171584341 267 dbSNP
rs1411756585 270 dbSNP
rs1417423803 278 dbSNP
rs1023845140 280 dbSNP
rs1384455614 290 dbSNP
rs1473402807 291 dbSNP
rs1387546908 292 dbSNP
rs1182138216 293 dbSNP
rs183844595 299 dbSNP
rs1238429824 301 dbSNP
rs1200098655 303 dbSNP
rs1435613772 304 dbSNP
rs982698998 305 dbSNP
rs1228878737 309 dbSNP
rs1358378936 311 dbSNP
rs1031070437 324 dbSNP
rs1244994951 325 dbSNP
rs1339962697 336 dbSNP
rs1332342737 337 dbSNP
rs957027909 337 dbSNP
rs1352892103 338 dbSNP
rs1328262405 339 dbSNP
rs1285506077 343 dbSNP
rs989475574 344 dbSNP
rs1162168554 345 dbSNP
rs1310653963 348 dbSNP
rs1381280253 349 dbSNP
rs1178627569 350 dbSNP
rs1468271126 350 dbSNP
rs915213852 350 dbSNP
rs80317858 360 dbSNP
rs931974510 363 dbSNP
rs1452779480 364 dbSNP
rs995365389 370 dbSNP
rs1232324967 373 dbSNP
rs1026387657 378 dbSNP
rs1221608465 379 dbSNP
rs950744448 380 dbSNP
rs773453339 383 dbSNP
rs144226146 387 dbSNP
rs1311159079 389 dbSNP
rs761213020 391 dbSNP
rs1371460548 393 dbSNP
rs911811509 402 dbSNP
rs1214386475 403 dbSNP
rs1262311279 409 dbSNP
rs527533117 412 dbSNP
rs1367483342 417 dbSNP
rs767035198 421 dbSNP
rs1424561922 424 dbSNP
rs1361639748 426 dbSNP
rs1161730200 438 dbSNP
rs1200950950 439 dbSNP
rs1264895897 443 dbSNP
rs1432208767 450 dbSNP
rs1191368119 464 dbSNP
rs1175840943 473 dbSNP
rs1266120701 480 dbSNP
rs974939613 486 dbSNP
rs1488571544 489 dbSNP
rs776858037 495 dbSNP
rs760006485 497 dbSNP
rs968234402 499 dbSNP
rs1316066910 502 dbSNP
rs1455620634 509 dbSNP
rs1220001939 517 dbSNP
rs1347522132 522 dbSNP
rs1036629150 525 dbSNP
rs897571525 526 dbSNP
rs1341686732 531 dbSNP
rs1291089698 558 dbSNP
rs1157392201 562 dbSNP
rs978273668 565 dbSNP
rs557974420 573 dbSNP
rs1470741995 575 dbSNP
rs1426675958 576 dbSNP
rs1405688291 578 dbSNP
rs1477828469 586 dbSNP
rs1263791857 589 dbSNP
rs1305010508 590 dbSNP
rs1485444586 592 dbSNP
rs1048804125 593 dbSNP
rs1204614292 596 dbSNP
rs567183637 600 dbSNP
rs1261424649 605 dbSNP
rs1329296614 605 dbSNP
rs1056113945 607 dbSNP
rs1318641849 608 dbSNP
rs916505068 609 dbSNP
rs1337324609 610 dbSNP
rs1237606028 611 dbSNP
rs947992229 611 dbSNP
rs1023858972 612 dbSNP
rs1360048657 617 dbSNP
rs1038282966 622 dbSNP
rs906805819 624 dbSNP
rs898351495 628 dbSNP
rs993999544 629 dbSNP
rs1487847670 634 dbSNP
rs1335612016 635 dbSNP
rs576316989 638 dbSNP
rs1003694749 640 dbSNP
rs1374261926 646 dbSNP
rs1048297772 647 dbSNP
rs1252146983 648 dbSNP
rs1168295852 654 dbSNP
rs1442008636 655 dbSNP
rs1031623051 661 dbSNP
rs1177147885 664 dbSNP
rs1380281166 667 dbSNP
rs34897385 667 dbSNP
rs956903995 669 dbSNP
rs531493364 674 dbSNP
rs765537782 677 dbSNP
rs187941614 678 dbSNP
rs953330460 681 dbSNP
rs1398900211 682 dbSNP
rs192980502 683 dbSNP
rs1444372650 685 dbSNP
rs1018860672 690 dbSNP
rs1380983994 691 dbSNP
rs1313977690 693 dbSNP
rs752328334 696 dbSNP
rs569249548 699 dbSNP
rs554033349 707 dbSNP
rs911795663 710 dbSNP
rs1295941915 711 dbSNP
rs537376496 712 dbSNP
rs1350414205 713 dbSNP
rs1165343715 716 dbSNP
rs1442579741 718 dbSNP
rs1384350785 724 dbSNP
rs996862490 728 dbSNP
rs1022530272 736 dbSNP
rs866471509 738 dbSNP
rs1248116419 740 dbSNP
rs971914079 753 dbSNP
rs577094160 756 dbSNP
rs1480319952 760 dbSNP
rs1310423803 761 dbSNP
rs968644880 769 dbSNP
rs1320600806 775 dbSNP
rs537938608 775 dbSNP
rs1291485017 778 dbSNP
rs1239406355 779 dbSNP
rs558278127 787 dbSNP
rs769119342 791 dbSNP
rs1204605225 793 dbSNP
rs978260236 795 dbSNP
rs1345555571 796 dbSNP
rs1304924562 798 dbSNP
rs1422647553 805 dbSNP
rs923697274 806 dbSNP
rs1159026231 807 dbSNP
rs1455097254 809 dbSNP
rs578210110 811 dbSNP
rs1365782561 813 dbSNP
rs763548275 814 dbSNP
rs1048775317 815 dbSNP
rs868020242 817 dbSNP
rs894240023 820 dbSNP
rs539630320 831 dbSNP
rs779774202 832 dbSNP
rs991906174 833 dbSNP
rs1206106995 836 dbSNP
rs1004171351 838 dbSNP
rs916285100 845 dbSNP
rs1423384963 846 dbSNP
rs1323691284 847 dbSNP
rs947733916 857 dbSNP
rs892616975 858 dbSNP
rs1318832119 861 dbSNP
rs1038718767 862 dbSNP
rs148805165 865 dbSNP
rs929813949 869 dbSNP
rs1046861484 878 dbSNP
rs1453306757 881 dbSNP
rs953466797 884 dbSNP
rs1178686373 885 dbSNP
rs1007556900 886 dbSNP
rs1019398344 887 dbSNP
rs1449140844 889 dbSNP
rs1260062186 890 dbSNP
rs1406566852 891 dbSNP
rs1449878415 893 dbSNP
rs554408036 894 dbSNP
rs1264546831 899 dbSNP
rs574358284 911 dbSNP
rs868458125 912 dbSNP
rs919198948 916 dbSNP
rs951853388 919 dbSNP
rs1229488311 924 dbSNP
rs984615579 926 dbSNP
rs1040425780 928 dbSNP
rs1453015381 931 dbSNP
rs1407131340 934 dbSNP
rs1338891193 939 dbSNP
rs370272556 948 dbSNP
rs1169052182 949 dbSNP
rs1315485311 951 dbSNP
rs1476668973 953 dbSNP
rs1217661275 966 dbSNP
rs757153002 968 dbSNP
rs1022988243 973 dbSNP
rs1462048290 974 dbSNP
rs968298612 974 dbSNP
rs372515074 985 dbSNP
rs1236292432 988 dbSNP
rs1483194760 989 dbSNP
rs1187223154 996 dbSNP
rs948510342 997 dbSNP
rs1031215008 999 dbSNP
rs1269465979 1002 dbSNP
rs1246469301 1018 dbSNP
rs1425906443 1019 dbSNP
rs960858178 1022 dbSNP
rs1317481779 1023 dbSNP
rs1476851983 1027 dbSNP
rs534923802 1035 dbSNP
rs1045494560 1038 dbSNP
rs1329622245 1040 dbSNP
rs1430244322 1044 dbSNP
rs928252017 1046 dbSNP
rs991937194 1050 dbSNP
rs1416019762 1051 dbSNP
rs1445658228 1055 dbSNP
rs1023371949 1060 dbSNP
rs1233029371 1061 dbSNP
rs1443626377 1061 dbSNP
rs934363901 1061 dbSNP
rs1441504324 1063 dbSNP
rs543319947 1069 dbSNP
rs183693933 1070 dbSNP
rs1431432795 1081 dbSNP
rs1272244458 1086 dbSNP
rs973737894 1089 dbSNP
rs1299907931 1092 dbSNP
rs1361393337 1093 dbSNP
rs919846762 1095 dbSNP
rs1043958154 1096 dbSNP
rs1378728417 1099 dbSNP
rs1280304902 1101 dbSNP
rs1444493944 1103 dbSNP
rs768296175 1107 dbSNP
rs889198207 1107 dbSNP
rs1334022717 1117 dbSNP
rs576013031 1121 dbSNP
rs929873277 1122 dbSNP
rs1019030272 1123 dbSNP
rs1283599085 1127 dbSNP
rs576326374 1129 dbSNP
rs1408295412 1132 dbSNP
rs912428337 1134 dbSNP
rs993525368 1135 dbSNP
rs1468193457 1141 dbSNP
rs1250398077 1143 dbSNP
rs943858759 1154 dbSNP
rs1200134065 1159 dbSNP
rs1040458259 1161 dbSNP
rs142456745 1162 dbSNP
rs931988447 1164 dbSNP
rs750171365 1168 dbSNP
rs1317246773 1176 dbSNP
rs1285264689 1178 dbSNP
rs1311931934 1183 dbSNP
rs755880824 1186 dbSNP
rs951985580 1187 dbSNP
rs984584508 1190 dbSNP
rs1301784461 1193 dbSNP
rs1436244854 1199 dbSNP
rs1265898462 1202 dbSNP
rs1346128342 1203 dbSNP
rs1160902935 1205 dbSNP
rs1398584203 1206 dbSNP
rs1487390302 1211 dbSNP
rs1410675860 1217 dbSNP
rs1176529770 1218 dbSNP
rs915778304 1219 dbSNP
rs10736731 1224 dbSNP
rs1269934598 1226 dbSNP
rs1479112330 1232 dbSNP
rs1170998937 1235 dbSNP
rs1486098467 1240 dbSNP
rs1424230856 1242 dbSNP
rs1218290952 1243 dbSNP
rs561776600 1244 dbSNP
rs928419747 1249 dbSNP
rs999816143 1250 dbSNP
rs1325707887 1256 dbSNP
rs1031247154 1259 dbSNP
rs896679797 1261 dbSNP
rs1219135339 1266 dbSNP
rs115787633 1268 dbSNP
rs1023404892 1273 dbSNP
rs1290858225 1281 dbSNP
rs1428965547 1284 dbSNP
rs1052810792 1286 dbSNP
rs759663125 1289 dbSNP
rs1337198897 1301 dbSNP
rs1470894871 1302 dbSNP
rs1427144638 1311 dbSNP
rs914155486 1315 dbSNP
rs1303204614 1326 dbSNP
rs1421108130 1327 dbSNP
rs969132424 1328 dbSNP
rs1184393497 1329 dbSNP
rs946987206 1331 dbSNP
rs1247763304 1334 dbSNP
rs1332498937 1343 dbSNP
rs1433884907 1359 dbSNP
rs974150502 1360 dbSNP
rs1209423728 1362 dbSNP
rs1308144433 1363 dbSNP
rs1297886740 1391 dbSNP
rs1044010650 1396 dbSNP
rs1315420672 1403 dbSNP
rs921843879 1403 dbSNP
rs933287892 1406 dbSNP
rs1454725572 1411 dbSNP
rs987531859 1411 dbSNP
rs1160392458 1412 dbSNP
rs1167754451 1412 dbSNP
rs1184529374 1413 dbSNP
rs1367359357 1413 dbSNP
rs1491025273 1414 dbSNP
rs761648311 1415 dbSNP
rs770852032 1415 dbSNP
rs1248530438 1416 dbSNP
rs1311804041 1416 dbSNP
rs1391866158 1416 dbSNP
rs1491381909 1416 dbSNP
rs200498816 1416 dbSNP
rs750155967 1416 dbSNP
rs755274557 1417 dbSNP
rs558448437 1418 dbSNP
rs889247511 1418 dbSNP
rs201258245 1419 dbSNP
rs867898470 1419 dbSNP
rs199826712 1420 dbSNP
rs951110228 1420 dbSNP
rs560816523 1421 dbSNP
rs79931643 1421 dbSNP
rs1040831754 1422 dbSNP
rs982690295 1422 dbSNP
rs766726993 1423 dbSNP
rs912459269 1423 dbSNP
rs1352123425 1424 dbSNP
rs1389600812 1424 dbSNP
rs1365985002 1425 dbSNP
rs943891537 1425 dbSNP
rs993885562 1428 dbSNP
rs1200737568 1430 dbSNP
rs55956222 1430 dbSNP
rs1188650498 1431 dbSNP
rs1264955420 1432 dbSNP
rs1281995026 1432 dbSNP
rs1453354041 1435 dbSNP
rs1042794957 1436 dbSNP
rs1246278304 1437 dbSNP
rs1470428150 1438 dbSNP
rs1201724049 1440 dbSNP
rs1450034940 1441 dbSNP
rs1180260346 1442 dbSNP
rs1266957398 1447 dbSNP
rs1205432483 1449 dbSNP
rs1266073934 1458 dbSNP
rs1486721490 1458 dbSNP
rs1227683539 1460 dbSNP
rs1378457004 1460 dbSNP
rs1438970747 1463 dbSNP
rs1324235887 1464 dbSNP
rs1284595823 1465 dbSNP
rs765171191 1466 dbSNP
rs1330084901 1472 dbSNP
rs975187970 1474 dbSNP
rs1295846291 1475 dbSNP
rs1392282380 1483 dbSNP
rs1383623127 1485 dbSNP
rs1403035595 1486 dbSNP
rs1319013166 1487 dbSNP
rs1457139669 1487 dbSNP
rs1322559401 1488 dbSNP
rs1407501081 1489 dbSNP
rs1477083894 1491 dbSNP
rs749631000 1491 dbSNP
rs922017027 1494 dbSNP
rs1311881288 1495 dbSNP
rs932045060 1496 dbSNP
rs1044192147 1497 dbSNP
rs1375095681 1499 dbSNP
rs1240093884 1504 dbSNP
rs772442935 1505 dbSNP
rs1343662148 1510 dbSNP
rs1270321027 1512 dbSNP
rs560771024 1516 dbSNP
rs1208130308 1520 dbSNP
rs935301533 1527 dbSNP
rs1052706603 1533 dbSNP
rs1438584741 1538 dbSNP
rs1336712743 1548 dbSNP
rs1200348661 1551 dbSNP
rs188361605 1558 dbSNP
rs1438795973 1559 dbSNP
rs1184144664 1563 dbSNP
rs1370048742 1565 dbSNP
rs1013771954 1572 dbSNP
rs1006055568 1575 dbSNP
rs1244810162 1576 dbSNP
rs1185306885 1582 dbSNP
rs1441812066 1591 dbSNP
rs777976367 1595 dbSNP
rs1273471541 1596 dbSNP
rs1023771278 1606 dbSNP
rs1360598188 1610 dbSNP
rs1286372802 1612 dbSNP
rs554883606 1614 dbSNP
rs905358627 1616 dbSNP
rs970268825 1617 dbSNP
rs1329563968 1618 dbSNP
rs1398578533 1620 dbSNP
rs1411751355 1632 dbSNP
rs550083013 1635 dbSNP
rs1168187465 1640 dbSNP
rs1425593421 1646 dbSNP
rs1335527758 1657 dbSNP
rs1161277001 1660 dbSNP
rs569154793 1662 dbSNP
rs955856486 1664 dbSNP
rs988469364 1665 dbSNP
rs1242761740 1667 dbSNP
rs775625659 1669 dbSNP
rs1283640733 1670 dbSNP
rs538278494 1674 dbSNP
rs951101449 1675 dbSNP
rs551808288 1682 dbSNP
rs1292415740 1683 dbSNP
rs1256328378 1685 dbSNP
rs1226983784 1695 dbSNP
rs947037731 1697 dbSNP
rs1280647898 1698 dbSNP
rs979655287 1701 dbSNP
rs1003809425 1703 dbSNP
rs1019502185 1704 dbSNP
rs192399654 1706 dbSNP
rs1258244224 1709 dbSNP
rs975219193 1709 dbSNP
rs921146784 1711 dbSNP
rs534308671 1712 dbSNP
rs1161265851 1713 dbSNP
rs979564161 1723 dbSNP
rs555320014 1724 dbSNP
rs1199548307 1734 dbSNP
rs935332866 1739 dbSNP
rs887757279 1742 dbSNP
rs1422467583 1743 dbSNP
rs1006191355 1745 dbSNP
rs1052403225 1746 dbSNP
rs574315633 1751 dbSNP
rs1465485482 1757 dbSNP
rs1211094430 1771 dbSNP
rs1022824098 1774 dbSNP
rs747155593 1780 dbSNP
rs1003118931 1783 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' acguuAGGGGUCGGGACga 5'
               |||||| |||||  
Target 5' ccuccUCCCCAACCCUG-- 3'
 		4 - 20
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000402010.2 | 3UTR | CCCCCUCCUCCCCAACCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
82 hsa-miR-6132 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT067294 NECAP1 NECAP endocytosis associated 1 2 10
MIRT100110 ABT1 activator of basal transcription 1 2 8
MIRT358583 CANX calnexin 2 2
MIRT445247 SEMA5A semaphorin 5A 2 2
MIRT445764 CCND3 cyclin D3 2 2
MIRT452388 LY6E lymphocyte antigen 6 family member E 2 4
MIRT452829 FAM131B family with sequence similarity 131 member B 2 2
MIRT453450 GLG1 golgi glycoprotein 1 2 2
MIRT455435 ID3 inhibitor of DNA binding 3, HLH protein 2 2
MIRT460629 IGFBP4 insulin like growth factor binding protein 4 2 2
MIRT461607 DPH2 DPH2 homolog 2 2
MIRT461989 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT464258 VCL vinculin 2 2
MIRT465713 TNFAIP1 TNF alpha induced protein 1 2 2
MIRT466475 TECPR2 tectonin beta-propeller repeat containing 2 2 7
MIRT467119 SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 2 4
MIRT468299 SFT2D2 SFT2 domain containing 2 2 2
MIRT469696 RAB5B RAB5B, member RAS oncogene family 2 8
MIRT469904 PTRF caveolae associated protein 1 2 2
MIRT470015 PTPLB 3-hydroxyacyl-CoA dehydratase 2 1 1
MIRT471385 PDPR pyruvate dehydrogenase phosphatase regulatory subunit 2 2
MIRT471409 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT471719 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT473608 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT476328 GLTSCR1L BRD4 interacting chromatin remodeling complex associated protein like 2 2
MIRT479448 CDK6 cyclin dependent kinase 6 2 2
MIRT482032 AMER1 APC membrane recruitment protein 1 2 2
MIRT482360 AGO2 argonaute 2, RISC catalytic component 2 2
MIRT484661 HOXD3 homeobox D3 2 4
MIRT486828 NDOR1 NADPH dependent diflavin oxidoreductase 1 2 2
MIRT487069 CLASP1 cytoplasmic linker associated protein 1 2 4
MIRT487196 NFASC neurofascin 2 4
MIRT487448 TFAP2B transcription factor AP-2 beta 2 4
MIRT487517 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT487640 BRSK2 BR serine/threonine kinase 2 2 4
MIRT487755 SKI SKI proto-oncogene 2 4
MIRT489944 CPLX1 complexin 1 2 2
MIRT491101 MSI1 musashi RNA binding protein 1 2 4
MIRT491181 LAMA5 laminin subunit alpha 5 2 2
MIRT492355 SEMA7A semaphorin 7A (John Milton Hagen blood group) 2 2
MIRT493918 FAM127B retrotransposon Gag like 8A 2 4
MIRT493932 FAM127A retrotransposon Gag like 8C 2 4
MIRT494679 ARID3A AT-rich interaction domain 3A 2 2
MIRT494814 AKAP11 A-kinase anchoring protein 11 2 2
MIRT494835 ADCY9 adenylate cyclase 9 2 2
MIRT495455 PNMAL2 paraneoplastic Ma antigen family member 8B 2 2
MIRT496962 MAP1LC3B microtubule associated protein 1 light chain 3 beta 2 2
MIRT526228 MTRNR2L5 MT-RNR2-like 5 2 2
MIRT531028 TDGF1P3 teratocarcinoma-derived growth factor 1 pseudogene 3 2 2
MIRT557110 HOXA3 homeobox A3 2 2
MIRT560514 POGK pogo transposable element derived with KRAB domain 2 2
MIRT567753 DLC1 DLC1 Rho GTPase activating protein 2 2
MIRT569608 TRIM29 tripartite motif containing 29 2 2
MIRT570242 CPNE5 copine 5 2 2
MIRT572327 HSPB6 heat shock protein family B (small) member 6 2 2
MIRT572373 ATOX1 antioxidant 1 copper chaperone 2 2
MIRT575024 Tecpr2 tectonin beta-propeller repeat containing 2 2 5
MIRT576146 Hmox1 heme oxygenase 1 2 2
MIRT612443 SMOC2 SPARC related modular calcium binding 2 2 2
MIRT615404 VDAC2 voltage dependent anion channel 2 2 2
MIRT629114 CYCS cytochrome c, somatic 2 2
MIRT631362 FOXI2 forkhead box I2 2 2
MIRT639322 THBD thrombomodulin 2 2
MIRT643797 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT669687 ABLIM1 actin binding LIM protein 1 2 2
MIRT670595 LLGL1 LLGL1, scribble cell polarity complex component 2 4
MIRT691190 NIF3L1 NGG1 interacting factor 3 like 1 2 2
MIRT691688 FLOT2 flotillin 2 2 2
MIRT697127 OTUD5 OTU deubiquitinase 5 2 2
MIRT700814 PHLDA2 pleckstrin homology like domain family A member 2 2 2
MIRT701248 NUP35 nucleoporin 35 2 2
MIRT702362 KLHL15 kelch like family member 15 2 2
MIRT703325 GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2 2
MIRT706060 PKD1 polycystin 1, transient receptor potential channel interacting 2 2
MIRT710475 CDH5 cadherin 5 2 2
MIRT713018 SLC4A2 solute carrier family 4 member 2 2 2
MIRT716427 RAB15 RAB15, member RAS oncogene family 2 2
MIRT718093 ABHD12 abhydrolase domain containing 12 2 2
MIRT718542 PIGQ phosphatidylinositol glycan anchor biosynthesis class Q 2 2
MIRT719122 CACFD1 calcium channel flower domain containing 1 2 2
MIRT721393 LDLRAD4 low density lipoprotein receptor class A domain containing 4 2 2
MIRT736283 CDC42 cell division cycle 42 2 0
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6132 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-6132 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-6132 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-6132 Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-6132 Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-6132 Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-6132 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-6132 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-6132 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)

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