pre-miRNA Information
pre-miRNA hsa-mir-1185-1   
Genomic Coordinates chr14: 101042977 - 101043062
Synonyms MIRN1185-1, hsa-mir-1185-1, MIR1185-1
Description Homo sapiens miR-1185-1 stem-loop
Comment This sequence was proposed as a miRNA candidate by Berezikov et al by RAKE analysis .
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-1185-1-3p
Sequence 53| AUAUACAGGGGGAGACUCUUAU |74
Evidence Not_experimental
Experiments
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 5 14 + 101043033 29233923 MiREDiBase
A-to-I 7 14 + 101043035 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs749794228 1 dbSNP
rs369414498 4 dbSNP
rs771096180 5 dbSNP
rs774958411 7 dbSNP
rs1226171972 11 dbSNP
rs1449899083 14 dbSNP
rs761183893 16 dbSNP
rs1380874583 20 dbSNP
rs771625921 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol MAP2K4   
Synonyms JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1
Description mitogen-activated protein kinase kinase 4
Transcript NM_003010   
Expression
Putative miRNA Targets on MAP2K4
3'UTR of MAP2K4
(miRNA target sites are highlighted)
>MAP2K4|NM_003010|3'UTR
   1 TATCGCTGCTACATCAGACTCTAGAAAAAAGGGCTGAGAGGAAGCAAGACGTAAAGAATTTTCATCCCGTATCACAGTGT
  81 TTTTATTGCTCGCCCAGACACCATGTGCAATAAGATTGGTGTTCGTTTCCATCATGTCTGTATACTCCTGTCACCTAGAA
 161 CGTGCATCCTTGTAATACCTGATTGATCACACAGTGTTAGTGCTGGTCAGAGAGACCTCATCCTGCTCTTTTGTGATGAA
 241 CATATTCATGAAATGTGGAAGTCAGTACGATCAAGTTGTTGACTGTGATTAGATCACATCTTAAATTCATTTCTAGACTC
 321 AAAACCTGGAGATGCAGCTACTGGAATGGTGTTTTGTCAGACTTCCAAATCCTGGAAGGACACAGTGATGAATGTACTAT
 401 GTCTGAACATAGAAACTCGGGCTTGAGTGAGAAGAGCTTGCACAGCCAACGAGACACATTGCCTTCTGGAGCTGGGAGAC
 481 AAAGGAGGAATTTACTTTCTTCACCAAGTGCAATAGATTACTGATGTGATATTCTGTTGCTTTACAGTTACAGTTGATGT
 561 TTGGGGATCGATGTGCTCAGCCAAATTTCCTGTTTGAAATATCATGTTAAATTAGAATGAATTTATCTTTACCAAAAACC
 641 ATGTTGCGTTCAAAGAGGTGAACATTAAAATATAGAGACAGGACAGAATGTGTTCTTTTCTCCTTTACCAGTCCTATTTT
 721 TCAATGGGAAGACTCAGGAGTCTGCCACTTGTCAAAGAAGGTGCTGATCCTAAGAATTTTTCATTCTCAGAATTCGGTGT
 801 GCTGCCAACTTGATGTTCCACCTGCCACAAACCACCAGGACTGAAAGAAGAAAACAGTACAGAAGGCAAAGTTTACAGAT
 881 GTTTTTAATTCTAGTATTTTATCTGGAACAACTTGTAGCAGCTATATATTTCCCCTTGGTCCCAAGCCTGATACTTTAGC
 961 CATCATAACTCACTAACAGGGAGAAGTAGCTAGTAGCAATGTGCCTTGATTGATTAGATAAAGATTTCTAGTAGGCAGCA
1041 AAAGACCAAATCTCAGTTGTTTGCTTCTTGCCATCACTGGTCCAGGTCTTCAGTTTCCGAATCTCTTTCCCTTCCCCTGT
1121 GGTCTATTGTCGCTATGTGACTTGCGCTTAATCCAATATTTTGCCTTTTTTCTATATCAAAAAACCTTTACAGTTAGCAG
1201 GGATGTTCCTTACCAAGGATTTTTAGCCCCAAATCTCTCATATTCGCTAGTGTTTAAAAGGCTAAGAATAGTGGGGCCCA
1281 GCCGATGTGGTAGGTGATAAAGAGGCATCTTTTCTAGAGACACATTGGACCAGATGAGGATCCGAAACGGCAGCCTTTAC
1361 GTTCATCACCTGCTAGAACCTCTCGTAGTCCATCACCATTTCTTGGCATTGGAATTCTACTGGAAAAAAATACAAAAAGC
1441 AAAACAAAACCCTCAGCACTGTTACAAGAGGCCATTTAAGTATCTTGTGCTTCTTCACTTACCCATTAGCCAGGTTCTCA
1521 TTAGGTTTTGCTTGGGCCTCCCTGGCACTGAACCTTAGGCTTTGTATGACAGTGAAGCAGCACTGTGAGTGGTTCAAGCA
1601 CACTGGAATATAAAACAGTCATGGCCTGAGATGCAGGTGATGCCATTACAGAACCAAATCGTGGCACGTATTGCTGTGTC
1681 TCCTCTCAGAGTGACAGTCATAAATACTGTCAAACAATAAAGGGAGAATGGTGCTGTTTAAAGTCACATCCCTGTAAATT
1761 GCAGAATTCAAAAGTGATTATCTCTTTGATCTACTTGCCTCATTTCCCTATCTTCTCCCCCACGGTATCCTAAACTTTAG
1841 ACTTCCCACTGTTCTGAAAGGAGACATTGCTCTATGTCTGCCTTCGACCACAGCAAGCCATCATCCTCCATTGCTCCCGG
1921 GGACTCAAGAGGAATCTGTTTCTCTGCTGTCAACTTCCCATCTGGCTCAGCATAGGGTCACTTTGCCATTATGCAAATGG
2001 AGATAAAAGCAATTCTGACTGTCCAGGAGCTAATCTGACCGTTCTATTGTGTGGATGACCACATAAGAAGGCAATTTTAG
2081 TGTATTAATCATAGATTATTATAAACTATAAACTTAAGGGCAAGGAGTTTATTACAATGTATCTTTATTAAAACAAAAGG
2161 GTGTATAGTGTTCACAAACTGTGAAAATAGTGTAAGAACTGTACATTGTGAGCTCTGGTTATTTTTCTCTTGTACCATAG
2241 AAAAATGTATAAAAATTATCAAAAAGCTAATGTGCAGGGATATTGCCTTATTTGTCTGTAAAAAATGGAGCTCAGTAACA
2321 TAACTGCTTCTTGGAGCTTTGGAATATTTTATCCTGTATTCTTGTTTGAATTCCTCCTCTATTTAAGATATATACATGGA
2401 ATCGAAGTGTTTATGTAATAGTTCTATCCTTTTGCCTGCAGGTCAGTTGTAATAAATCTAGGATGTGATGATGACTTTGT
2481 AATTTGATTTTCTGAAATCAGACCCTGAGAGGGGAAAATCTTAAAGTAAATTACATTAAATTATCTGTGCATTTCACACC
2561 AGGGAAAATGA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uauucuCAGAGG--G---GGACAUAUa 5'
                ||:|||  |   :||||||| 
Target 5' gtgttcGTTTCCATCATGTCTGTATAc 3'
119 - 145 150.00 -11.80
2
miRNA  3' uaUUCUCAGAGGGGGACAUAua 5'
            || | |:|: :|||||||  
Target 5' ggAATA-TTTTATCCTGTATtc 3'
2341 - 2361 139.00 -10.30
3
miRNA  3' uauUCUCAGAG-GGGGACAUAUa 5'
             | |||| | :||||||| | 
Target 5' tttAAAGTCACATCCCTGTAAAt 3'
1737 - 1759 135.00 -15.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN15201838 4 COSMIC
COSN30677854 5 COSMIC
COSN32065052 28 COSMIC
COSN30645882 31 COSMIC
COSN31504262 31 COSMIC
COSN31487689 37 COSMIC
COSN13700681 40 COSMIC
COSN30751905 51 COSMIC
COSN31611911 57 COSMIC
COSN31610256 135 COSMIC
COSN30605360 148 COSMIC
COSN30505182 165 COSMIC
COSN26569892 172 COSMIC
COSN30108106 213 COSMIC
COSN26604435 215 COSMIC
COSN8831289 236 COSMIC
COSN8602349 405 COSMIC
COSN31529127 419 COSMIC
COSN28673266 432 COSMIC
COSN31591115 446 COSMIC
COSN30540989 503 COSMIC
COSN31529669 517 COSMIC
COSN8602350 535 COSMIC
COSN31557405 546 COSMIC
COSN229730 555 COSMIC
COSN31609641 625 COSMIC
COSN31541966 640 COSMIC
COSN31517214 775 COSMIC
COSN31519951 796 COSMIC
COSN26568620 895 COSMIC
COSN21669330 1274 COSMIC
COSN6650014 1329 COSMIC
COSN20188867 1662 COSMIC
COSN1713429 2064 COSMIC
COSN30172676 2068 COSMIC
COSN26508918 2124 COSMIC
COSN20243415 2250 COSMIC
COSN31479761 2314 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs759895365 4 dbSNP
rs201971628 5 dbSNP
rs1160522880 8 dbSNP
rs753044476 20 dbSNP
rs189817203 22 dbSNP
rs1177317456 26 dbSNP
rs750313329 28 dbSNP
rs1440414957 29 dbSNP
rs758163020 36 dbSNP
rs1300906062 42 dbSNP
rs1328873603 43 dbSNP
rs757919548 49 dbSNP
rs1444294698 50 dbSNP
rs368292817 51 dbSNP
rs376888511 52 dbSNP
rs1376940685 66 dbSNP
rs1173871300 69 dbSNP
rs182465459 70 dbSNP
rs991391012 77 dbSNP
rs1447077528 78 dbSNP
rs1217388804 83 dbSNP
rs1471455387 86 dbSNP
rs139724158 89 dbSNP
rs565243535 92 dbSNP
rs185329765 104 dbSNP
rs977552536 111 dbSNP
rs755582365 125 dbSNP
rs754518168 126 dbSNP
rs1277957623 128 dbSNP
rs1162191662 130 dbSNP
rs1413774405 136 dbSNP
rs778639435 138 dbSNP
rs541396988 149 dbSNP
rs1401809070 151 dbSNP
rs1278849405 158 dbSNP
rs1320294154 162 dbSNP
rs933099258 163 dbSNP
rs1051435127 173 dbSNP
rs888807017 181 dbSNP
rs1373192745 188 dbSNP
rs943587891 196 dbSNP
rs190190304 202 dbSNP
rs1386400527 207 dbSNP
rs751116797 209 dbSNP
rs1243587953 211 dbSNP
rs1420115201 225 dbSNP
rs899306678 226 dbSNP
rs773452215 232 dbSNP
rs1283517036 234 dbSNP
rs1217729861 238 dbSNP
rs1447362213 241 dbSNP
rs1283547066 242 dbSNP
rs868621549 242 dbSNP
rs1206757986 243 dbSNP
rs575260150 259 dbSNP
rs1225401711 266 dbSNP
rs1232125778 269 dbSNP
rs1353218981 270 dbSNP
rs1433396058 276 dbSNP
rs1346168731 298 dbSNP
rs1317988135 304 dbSNP
rs1281475093 306 dbSNP
rs1464067275 327 dbSNP
rs993682136 336 dbSNP
rs1203885563 344 dbSNP
rs1397268930 352 dbSNP
rs530205553 357 dbSNP
rs1026780896 366 dbSNP
rs548739275 375 dbSNP
rs1411982419 383 dbSNP
rs1188492312 389 dbSNP
rs1462922916 393 dbSNP
rs1241337469 394 dbSNP
rs1049438 402 dbSNP
rs1185791242 403 dbSNP
rs1237265742 410 dbSNP
rs1470773420 419 dbSNP
rs1273702690 430 dbSNP
rs563431936 438 dbSNP
rs1160822984 439 dbSNP
rs1004076840 444 dbSNP
rs146597820 450 dbSNP
rs183470579 451 dbSNP
rs1270006924 452 dbSNP
rs1177410004 456 dbSNP
rs959395850 457 dbSNP
rs1373883498 464 dbSNP
rs570740002 475 dbSNP
rs1327162125 478 dbSNP
rs1450741872 483 dbSNP
rs991338612 498 dbSNP
rs1021515339 502 dbSNP
rs1336161499 509 dbSNP
rs1410765497 512 dbSNP
rs542637158 513 dbSNP
rs977289694 514 dbSNP
rs1277757102 518 dbSNP
rs924479052 521 dbSNP
rs748422493 522 dbSNP
rs1487424435 523 dbSNP
rs1234141930 525 dbSNP
rs954466763 533 dbSNP
rs1223668429 544 dbSNP
rs1306613460 551 dbSNP
rs188410287 555 dbSNP
rs1320887488 564 dbSNP
rs546555189 566 dbSNP
rs910190495 570 dbSNP
rs1255844126 571 dbSNP
rs1366046920 578 dbSNP
rs943033266 579 dbSNP
rs1037916538 585 dbSNP
rs568012626 597 dbSNP
rs535168966 598 dbSNP
rs1250331492 601 dbSNP
rs920852236 601 dbSNP
rs193245128 603 dbSNP
rs576184750 605 dbSNP
rs1047889723 612 dbSNP
rs906720725 618 dbSNP
rs1177318276 626 dbSNP
rs537272159 633 dbSNP
rs1480024657 643 dbSNP
rs1249242020 648 dbSNP
rs141440676 649 dbSNP
rs774589194 652 dbSNP
rs1055150998 655 dbSNP
rs577441740 658 dbSNP
rs541405516 664 dbSNP
rs1310996638 671 dbSNP
rs1010865686 674 dbSNP
rs1224460814 675 dbSNP
rs1349960962 676 dbSNP
rs1286457201 681 dbSNP
rs1416885311 687 dbSNP
rs1376236303 689 dbSNP
rs1021464279 698 dbSNP
rs764885646 704 dbSNP
rs1049439 706 dbSNP
rs1172239991 708 dbSNP
rs1396920620 710 dbSNP
rs968661720 713 dbSNP
rs28921113 717 dbSNP
rs1031489798 718 dbSNP
rs28921114 726 dbSNP
rs386576571 726 dbSNP
rs796558922 726 dbSNP
rs184089088 737 dbSNP
rs1284597734 738 dbSNP
rs910305030 748 dbSNP
rs1232049382 751 dbSNP
rs1475343987 753 dbSNP
rs1251569890 762 dbSNP
rs11555725 767 dbSNP
rs1482472280 771 dbSNP
rs1262803165 773 dbSNP
rs1217135857 791 dbSNP
rs563793589 796 dbSNP
rs1235193997 797 dbSNP
rs59832266 798 dbSNP
rs1048481585 804 dbSNP
rs1363833074 805 dbSNP
rs186704791 806 dbSNP
rs1271080885 814 dbSNP
rs1431564879 818 dbSNP
rs1386304211 820 dbSNP
rs201362372 821 dbSNP
rs1330387946 827 dbSNP
rs1373923998 828 dbSNP
rs1461503672 833 dbSNP
rs1476264484 842 dbSNP
rs1416789044 847 dbSNP
rs191563418 857 dbSNP
rs1429854132 861 dbSNP
rs1264333760 863 dbSNP
rs1187417045 865 dbSNP
rs1464877789 866 dbSNP
rs1266751778 868 dbSNP
rs1369749772 870 dbSNP
rs1425166109 880 dbSNP
rs1215710668 882 dbSNP
rs1055095564 896 dbSNP
rs1264885041 904 dbSNP
rs1304926393 919 dbSNP
rs1242889701 925 dbSNP
rs895242550 926 dbSNP
rs528384363 927 dbSNP
rs777910390 934 dbSNP
rs1363028104 945 dbSNP
rs183860741 955 dbSNP
rs1043689070 957 dbSNP
rs1441474446 959 dbSNP
rs1389390633 969 dbSNP
rs1160906936 978 dbSNP
rs1463216885 995 dbSNP
rs1443041330 998 dbSNP
rs902541481 999 dbSNP
rs998752463 1000 dbSNP
rs565054493 1003 dbSNP
rs1032024002 1019 dbSNP
rs954528193 1031 dbSNP
rs1266804062 1034 dbSNP
rs1208088180 1040 dbSNP
rs1481771015 1049 dbSNP
rs1252105147 1053 dbSNP
rs1227466480 1056 dbSNP
rs1008742120 1057 dbSNP
rs1305270834 1059 dbSNP
rs1295808707 1060 dbSNP
rs1341925536 1072 dbSNP
rs1330396821 1074 dbSNP
rs1017481412 1077 dbSNP
rs1392590604 1081 dbSNP
rs1396857391 1087 dbSNP
rs530627261 1089 dbSNP
rs568009724 1099 dbSNP
rs188576778 1100 dbSNP
rs1388715301 1102 dbSNP
rs1175878255 1108 dbSNP
rs544055289 1109 dbSNP
rs1209380455 1121 dbSNP
rs1377538282 1122 dbSNP
rs192717367 1123 dbSNP
rs973174439 1127 dbSNP
rs1027311137 1132 dbSNP
rs1448913832 1133 dbSNP
rs1204708462 1135 dbSNP
rs1482172052 1136 dbSNP
rs759629494 1137 dbSNP
rs1344267831 1139 dbSNP
rs1273004488 1145 dbSNP
rs568630474 1146 dbSNP
rs1335849108 1147 dbSNP
rs1389291541 1148 dbSNP
rs1287089839 1157 dbSNP
rs1407647100 1160 dbSNP
rs761285228 1164 dbSNP
rs35163626 1166 dbSNP
rs1445060167 1167 dbSNP
rs1165389249 1171 dbSNP
rs928209569 1172 dbSNP
rs539172755 1175 dbSNP
rs1171349870 1179 dbSNP
rs990939743 1185 dbSNP
rs373075028 1187 dbSNP
rs1386539830 1192 dbSNP
rs1259832318 1193 dbSNP
rs1188074227 1203 dbSNP
rs570995174 1205 dbSNP
rs1049441 1216 dbSNP
rs1049442 1227 dbSNP
rs1441621558 1230 dbSNP
rs1276178698 1233 dbSNP
rs1432379329 1244 dbSNP
rs1319532533 1247 dbSNP
rs1266966506 1251 dbSNP
rs946789596 1260 dbSNP
rs377467531 1263 dbSNP
rs1317766247 1265 dbSNP
rs1446758718 1267 dbSNP
rs1340253930 1269 dbSNP
rs1332562342 1273 dbSNP
rs1049443 1282 dbSNP
rs1402972204 1284 dbSNP
rs1320385884 1285 dbSNP
rs1158570722 1286 dbSNP
rs902487359 1290 dbSNP
rs1420373118 1292 dbSNP
rs935329976 1299 dbSNP
rs1053006065 1308 dbSNP
rs1352990895 1325 dbSNP
rs890359018 1326 dbSNP
rs4792219 1329 dbSNP
rs1465328146 1332 dbSNP
rs140706208 1339 dbSNP
rs1185139556 1340 dbSNP
rs1336323354 1343 dbSNP
rs1289886706 1344 dbSNP
rs1227417275 1345 dbSNP
rs542266426 1349 dbSNP
rs1423135285 1350 dbSNP
rs1282839382 1353 dbSNP
rs1433283338 1357 dbSNP
rs900368453 1361 dbSNP
rs1433459464 1362 dbSNP
rs557420020 1371 dbSNP
rs575793095 1385 dbSNP
rs867970900 1386 dbSNP
rs1169468093 1388 dbSNP
rs1449844751 1392 dbSNP
rs1389542979 1393 dbSNP
rs1272207826 1399 dbSNP
rs546021188 1409 dbSNP
rs1316292529 1424 dbSNP
rs150125305 1433 dbSNP
rs1198462744 1436 dbSNP
rs185127839 1442 dbSNP
rs1449551534 1450 dbSNP
rs1157958844 1451 dbSNP
rs1343339167 1460 dbSNP
rs138715568 1460 dbSNP
rs1297243446 1461 dbSNP
rs1226887500 1462 dbSNP
rs991060540 1464 dbSNP
rs1454261804 1465 dbSNP
rs561848490 1466 dbSNP
rs1331118504 1474 dbSNP
rs916718655 1486 dbSNP
rs1389352561 1487 dbSNP
rs1166430649 1489 dbSNP
rs1304915457 1490 dbSNP
rs1377457996 1491 dbSNP
rs1455569997 1492 dbSNP
rs1425743763 1493 dbSNP
rs528827767 1494 dbSNP
rs1476747022 1499 dbSNP
rs550147826 1505 dbSNP
rs1205437959 1510 dbSNP
rs979445489 1511 dbSNP
rs1274404237 1512 dbSNP
rs190166554 1513 dbSNP
rs1331317306 1525 dbSNP
rs1226713597 1530 dbSNP
rs1267596512 1532 dbSNP
rs1324454535 1540 dbSNP
rs1365600685 1546 dbSNP
rs935461626 1556 dbSNP
rs1410688903 1564 dbSNP
rs182288643 1566 dbSNP
rs891149587 1572 dbSNP
rs944594322 1577 dbSNP
rs1359729229 1584 dbSNP
rs1038984510 1590 dbSNP
rs35027510 1598 dbSNP
rs1409568600 1603 dbSNP
rs1182214518 1607 dbSNP
rs1252669600 1627 dbSNP
rs1472090457 1628 dbSNP
rs1249123975 1636 dbSNP
rs1471318987 1638 dbSNP
rs1484435890 1644 dbSNP
rs1180759126 1645 dbSNP
rs1256898851 1651 dbSNP
rs1210067401 1656 dbSNP
rs548929345 1661 dbSNP
rs994677092 1662 dbSNP
rs751434207 1668 dbSNP
rs886181583 1669 dbSNP
rs142822302 1677 dbSNP
rs1299229349 1679 dbSNP
rs1286663558 1683 dbSNP
rs1004674744 1684 dbSNP
rs1302007012 1688 dbSNP
rs1445768108 1693 dbSNP
rs1408539515 1696 dbSNP
rs1035080828 1698 dbSNP
rs1456244991 1711 dbSNP
rs1166665669 1716 dbSNP
rs753340576 1716 dbSNP
rs553603101 1718 dbSNP
rs1221134145 1725 dbSNP
rs568748222 1730 dbSNP
rs1023843732 1732 dbSNP
rs1482585604 1758 dbSNP
rs536188976 1761 dbSNP
rs189374285 1772 dbSNP
rs980000346 1776 dbSNP
rs1266242857 1780 dbSNP
rs1247302010 1781 dbSNP
rs180737708 1783 dbSNP
rs956984930 1793 dbSNP
rs1049444 1799 dbSNP
rs1049445 1800 dbSNP
rs1432148263 1801 dbSNP
rs752444743 1802 dbSNP
rs1394042006 1805 dbSNP
rs539873890 1811 dbSNP
rs1268948453 1812 dbSNP
rs557978166 1816 dbSNP
rs1481152731 1817 dbSNP
rs912540518 1821 dbSNP
rs572955852 1824 dbSNP
rs532604526 1825 dbSNP
rs1458138986 1828 dbSNP
rs1367499450 1829 dbSNP
rs1164597690 1830 dbSNP
rs1038932037 1833 dbSNP
rs1392347369 1843 dbSNP
rs921854614 1849 dbSNP
rs1464808450 1852 dbSNP
rs561571491 1855 dbSNP
rs1488954694 1857 dbSNP
rs930582226 1864 dbSNP
rs747382916 1866 dbSNP
rs1344058810 1875 dbSNP
rs1049365757 1879 dbSNP
rs886298488 1880 dbSNP
rs1005010123 1883 dbSNP
rs1056235463 1886 dbSNP
rs896115338 1887 dbSNP
rs570349832 1889 dbSNP
rs1011874766 1911 dbSNP
rs1023290482 1914 dbSNP
rs968266822 1917 dbSNP
rs1449446024 1919 dbSNP
rs1428329995 1920 dbSNP
rs1201183255 1923 dbSNP
rs1001146096 1927 dbSNP
rs1031572420 1928 dbSNP
rs1438784557 1930 dbSNP
rs1193268392 1933 dbSNP
rs1484137312 1937 dbSNP
rs956909924 1939 dbSNP
rs1275146136 1947 dbSNP
rs987269021 1954 dbSNP
rs1803981 1956 dbSNP
rs374613560 1958 dbSNP
rs1276530509 1966 dbSNP
rs771371631 1972 dbSNP
rs1330002178 1974 dbSNP
rs912655032 1987 dbSNP
rs1309066008 1988 dbSNP
rs1215388789 1989 dbSNP
rs1429511984 2000 dbSNP
rs1395044798 2004 dbSNP
rs1174841059 2009 dbSNP
rs975405184 2032 dbSNP
rs1377173527 2039 dbSNP
rs1197306206 2040 dbSNP
rs573591463 2041 dbSNP
rs1049001581 2042 dbSNP
rs185090127 2047 dbSNP
rs1280385534 2049 dbSNP
rs940538048 2064 dbSNP
rs1056106567 2065 dbSNP
rs1253785833 2070 dbSNP
rs896230052 2073 dbSNP
rs1245630122 2083 dbSNP
rs1287314201 2085 dbSNP
rs1485966651 2086 dbSNP
rs1011989097 2090 dbSNP
rs562100258 2096 dbSNP
rs1044691395 2097 dbSNP
rs532801531 2098 dbSNP
rs1336514202 2100 dbSNP
rs1397148940 2106 dbSNP
rs1402078729 2108 dbSNP
rs1187924346 2114 dbSNP
rs1392393675 2120 dbSNP
rs1458876055 2124 dbSNP
rs1412724964 2132 dbSNP
rs377631607 2138 dbSNP
rs748132714 2142 dbSNP
rs903555542 2142 dbSNP
rs1239008513 2144 dbSNP
rs1001497643 2150 dbSNP
rs1407592410 2151 dbSNP
rs1441813123 2154 dbSNP
rs1031272395 2155 dbSNP
rs1321599710 2155 dbSNP
rs575309080 2162 dbSNP
rs993299076 2168 dbSNP
rs560013150 2178 dbSNP
rs892592198 2180 dbSNP
rs1266865781 2181 dbSNP
rs146989618 2183 dbSNP
rs1357967186 2191 dbSNP
rs546863393 2200 dbSNP
rs568709937 2203 dbSNP
rs964122032 2205 dbSNP
rs1389911014 2213 dbSNP
rs1382916760 2214 dbSNP
rs1335329990 2219 dbSNP
rs975519554 2230 dbSNP
rs1389507585 2235 dbSNP
rs1319914134 2237 dbSNP
rs1399223938 2238 dbSNP
rs775548386 2247 dbSNP
rs1416187277 2248 dbSNP
rs1163694710 2250 dbSNP
rs1358296663 2253 dbSNP
rs1383091869 2261 dbSNP
rs1190442821 2273 dbSNP
rs1026975007 2275 dbSNP
rs1465263417 2281 dbSNP
rs952760609 2283 dbSNP
rs1213013577 2285 dbSNP
rs1226565951 2288 dbSNP
rs985072606 2291 dbSNP
rs1317041176 2299 dbSNP
rs907792847 2300 dbSNP
rs940637164 2312 dbSNP
rs28921115 2315 dbSNP
rs1245885530 2320 dbSNP
rs1231285529 2321 dbSNP
rs1366528672 2323 dbSNP
rs1338784947 2330 dbSNP
rs1463815434 2336 dbSNP
rs538194763 2356 dbSNP
rs1188266269 2357 dbSNP
rs917770650 2359 dbSNP
rs1351896335 2361 dbSNP
rs1324471491 2371 dbSNP
rs947792171 2377 dbSNP
rs1474038251 2378 dbSNP
rs1162005562 2380 dbSNP
rs1044803816 2390 dbSNP
rs28921116 2392 dbSNP
rs771988128 2393 dbSNP
rs551297905 2397 dbSNP
rs1401423730 2404 dbSNP
rs569233824 2405 dbSNP
rs936355059 2419 dbSNP
rs1053083628 2427 dbSNP
rs892713513 2430 dbSNP
rs1272909578 2446 dbSNP
rs1213267304 2447 dbSNP
rs773074624 2461 dbSNP
rs537682530 2479 dbSNP
rs1337104125 2492 dbSNP
rs1008936178 2494 dbSNP
rs1391598759 2501 dbSNP
rs1342063571 2502 dbSNP
rs1309667915 2506 dbSNP
rs539463944 2506 dbSNP
rs1283569342 2507 dbSNP
rs558202320 2510 dbSNP
rs76996718 2512 dbSNP
rs1019775986 2518 dbSNP
rs1373426420 2521 dbSNP
rs1168234794 2527 dbSNP
rs191257357 2530 dbSNP
rs183170582 2531 dbSNP
rs1190100164 2536 dbSNP
rs1027073111 2540 dbSNP
rs952786535 2541 dbSNP
rs1052139112 2542 dbSNP
rs982794513 2544 dbSNP
rs1016048078 2548 dbSNP
rs1232599444 2552 dbSNP
rs777773191 2559 dbSNP
rs1203072758 2562 dbSNP
rs1314410484 2568 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' uauucucAGAGG--G---GGACAUAUa 5'
                 |:|||  |   :||||||| 
Target 5' -------UUUCCAUCAUGUCUGUAUAc 3'
1 - 20
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000415385.3 | 3UTR | UUUCCAUCAUGUCUGUAUACUCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
114 hsa-miR-1185-1-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066415 TBK1 TANK binding kinase 1 2 4
MIRT073567 NR2F2 nuclear receptor subfamily 2 group F member 2 2 2
MIRT074516 USP1 ubiquitin specific peptidase 1 2 4
MIRT080576 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2 6
MIRT086539 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 2
MIRT086547 MOB4 MOB family member 4, phocein 2 2
MIRT088684 EML4 echinoderm microtubule associated protein like 4 2 4
MIRT090811 MBNL1 muscleblind like splicing regulator 1 2 4
MIRT095500 PURA purine rich element binding protein A 2 2
MIRT109530 KLHL15 kelch like family member 15 2 6
MIRT109807 ZFX zinc finger protein, X-linked 2 2
MIRT117888 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT120273 GSK3B glycogen synthase kinase 3 beta 2 4
MIRT149892 LDLR low density lipoprotein receptor 2 2
MIRT178475 LCOR ligand dependent nuclear receptor corepressor 2 4
MIRT193445 RORA RAR related orphan receptor A 2 2
MIRT198527 DSG2 desmoglein 2 2 2
MIRT226427 TP53INP1 tumor protein p53 inducible nuclear protein 1 2 2
MIRT227669 SET SET nuclear proto-oncogene 2 2
MIRT320405 HOXA9 homeobox A9 2 2
MIRT407774 MRPL35 mitochondrial ribosomal protein L35 2 2
MIRT439228 ZMIZ1 zinc finger MIZ-type containing 1 1 1
MIRT439312 VAT1L vesicle amine transport 1 like 1 1
MIRT439421 TMOD1 tropomodulin 1 1 1
MIRT439446 TMEM104 transmembrane protein 104 1 1
MIRT439524 STIM2 stromal interaction molecule 2 1 1
MIRT439612 SLC29A1 solute carrier family 29 member 1 (Augustine blood group) 1 1
MIRT439997 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 1 1
MIRT440017 PCSK1 proprotein convertase subtilisin/kexin type 1 1 1
MIRT440131 NCOA4 nuclear receptor coactivator 4 1 1
MIRT440311 LRRC1 leucine rich repeat containing 1 1 1
MIRT440475 IAPP islet amyloid polypeptide 1 1
MIRT440511 HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 1 1
MIRT440617 FOXA2 forkhead box A2 1 1
MIRT440666 FBXL16 F-box and leucine rich repeat protein 16 1 1
MIRT440705 ERO1LB endoplasmic reticulum oxidoreductase 1 beta 1 1
MIRT441007 CAPZA2 capping actin protein of muscle Z-line alpha subunit 2 1 1
MIRT441018 CAND1 cullin associated and neddylation dissociated 1 1 1
MIRT441062 C1orf43 chromosome 1 open reading frame 43 1 1
MIRT441209 ARCN1 archain 1 1 1
MIRT449461 HAT1 histone acetyltransferase 1 2 2
MIRT467104 SRI sorcin 2 2
MIRT468060 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 10
MIRT468476 SESN3 sestrin 3 2 4
MIRT473533 MAX MYC associated factor X 2 2
MIRT473852 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT474711 KIF13A kinesin family member 13A 2 6
MIRT481665 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT485120 SF3B3 splicing factor 3b subunit 3 2 2
MIRT493055 MTFR1 mitochondrial fission regulator 1 2 2
MIRT504258 C1orf147 chromosome 1 open reading frame 147 2 4
MIRT504361 ARID1B AT-rich interaction domain 1B 2 4
MIRT505748 SENP1 SUMO1/sentrin specific peptidase 1 2 8
MIRT506298 PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 2 6
MIRT508442 ZNF608 zinc finger protein 608 2 4
MIRT512782 COL4A3BP collagen type IV alpha 3 binding protein 2 2
MIRT520447 TSPAN2 tetraspanin 2 2 4
MIRT522133 NRBF2 nuclear receptor binding factor 2 2 6
MIRT522395 MYADM myeloid associated differentiation marker 2 4
MIRT523397 GRIK3 glutamate ionotropic receptor kainate type subunit 3 2 4
MIRT523938 E2F8 E2F transcription factor 8 2 4
MIRT524349 CREB1 cAMP responsive element binding protein 1 2 2
MIRT524711 BRMS1L breast cancer metastasis-suppressor 1 like 2 4
MIRT525134 ZNF256 zinc finger protein 256 2 2
MIRT525710 DCAF12L2 DDB1 and CUL4 associated factor 12 like 2 2 2
MIRT531264 PPIL3 peptidylprolyl isomerase like 3 2 2
MIRT538844 BTG1 BTG anti-proliferation factor 1 2 2
MIRT541366 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT542093 KCNK10 potassium two pore domain channel subfamily K member 10 2 6
MIRT543770 RBM12B RNA binding motif protein 12B 2 4
MIRT543940 NCOA7 nuclear receptor coactivator 7 2 2
MIRT545150 GABRG1 gamma-aminobutyric acid type A receptor gamma1 subunit 2 2
MIRT545842 ZNF264 zinc finger protein 264 2 4
MIRT548057 GOLGA7 golgin A7 2 2
MIRT549242 ATXN1L ataxin 1 like 2 4
MIRT551829 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT552484 ZNF136 zinc finger protein 136 2 2
MIRT553663 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT554988 RAB39B RAB39B, member RAS oncogene family 2 2
MIRT555760 PCTP phosphatidylcholine transfer protein 2 2
MIRT556923 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 4
MIRT564991 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT566458 PGGT1B protein geranylgeranyltransferase type I subunit beta 2 2
MIRT566538 PANK3 pantothenate kinase 3 2 2
MIRT567732 DLX2 distal-less homeobox 2 2 2
MIRT570081 KANSL1L KAT8 regulatory NSL complex subunit 1 like 2 2
MIRT571735 RNF11 ring finger protein 11 2 2
MIRT573529 MDM2 MDM2 proto-oncogene 2 2
MIRT574459 RPS16 ribosomal protein S16 2 2
MIRT574992 Phka1 phosphorylase kinase alpha 1 2 3
MIRT576349 Pxdn peroxidasin 2 2
MIRT610196 CD99 CD99 molecule (Xg blood group) 2 4
MIRT612920 GPRIN3 GPRIN family member 3 2 2
MIRT615021 DUSP6 dual specificity phosphatase 6 2 2
MIRT623573 IRS1 insulin receptor substrate 1 2 2
MIRT624437 CASD1 CAS1 domain containing 1 2 2
MIRT628714 ZNF585A zinc finger protein 585A 2 2
MIRT639565 PCK1 phosphoenolpyruvate carboxykinase 1 2 4
MIRT641485 POLA2 DNA polymerase alpha 2, accessory subunit 2 2
MIRT641657 PAPOLG poly(A) polymerase gamma 2 2
MIRT642210 RUVBL2 RuvB like AAA ATPase 2 2 2
MIRT653010 STX7 syntaxin 7 2 2
MIRT656130 MSH6 mutS homolog 6 2 2
MIRT656893 KIAA2018 upstream transcription factor family member 3 2 2
MIRT660130 BRPF3 bromodomain and PHD finger containing 3 2 2
MIRT660855 AFAP1 actin filament associated protein 1 2 2
MIRT676843 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 3
MIRT681473 DIP2A disco interacting protein 2 homolog A 2 2
MIRT682253 RS1 retinoschisin 1 2 2
MIRT694296 COPB2 coatomer protein complex subunit beta 2 2 2
MIRT694401 ALDH1A3 aldehyde dehydrogenase 1 family member A3 2 2
MIRT705277 BACH1 BTB domain and CNC homolog 1 2 2
MIRT720833 C1orf52 chromosome 1 open reading frame 52 2 2
MIRT735713 SIRT1 sirtuin 1 2 0
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-1185-1 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-1185-1 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-1185-1-3p Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-1185-1-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-1185-1-3p Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-1185-1-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-1185-1-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-1185-1-3p Palbociclib 5330286 NSC758247 approved resistant cell line (T47D)
hsa-miR-1185-1-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-1185-1-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-1185-1-3p Prednisone/Azathioprine/Methotrexate/Cyclophosphamide/Mycophenolate mofetil sensitive tissue (myasthenia gravis)
hsa-miR-1185-1-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-1185-1-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-1185-1-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-1185-1-3p Tamoxifen+Fulvestrant resistant cell line (LCC9)
hsa-miR-1185-1-3p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-1185-1-3p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-1185-1-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-1185-1-3p Gemcitabine 60750 NSC613327 approved resistant cell line (MDA-231)
hsa-miR-1185-1-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-1185-1-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-1185-1-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-1185-1-3p Cisplatin 5460033 NSC119875 approved resistant cell line (TOV-112D)

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