pre-miRNA Information
pre-miRNA hsa-mir-4480   
Genomic Coordinates chr10: 12578753 - 12578823
Description Homo sapiens miR-4480 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4480
Sequence 44| AGCCAAGUGGAAGUUACUUUA |64
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 1 10 + 12578796 23291724, 27587585 MiREDiBase
A-to-I 12 10 + 12578807 23291724, 27587585 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs929437808 7 dbSNP
rs1454494557 9 dbSNP
rs1345041659 17 dbSNP
rs561601367 21 dbSNP
Putative Targets

Gene Information
Gene Symbol MAFK   
Synonyms NFE2U, P18
Description MAF bZIP transcription factor K
Transcript NM_002360   
Expression
Putative miRNA Targets on MAFK
3'UTR of MAFK
(miRNA target sites are highlighted)
>MAFK|NM_002360|3'UTR
   1 TGCCGGCCGGGGGCGGGGGGTGGCGGGCGGCGGGCGGCGGGCAGGCGGGTGGGGGCACACCCCTCGTACCTGTCACTGGG
  81 ATGCAGACTCTCGACATCCGAGTCCAAGCGCAGGCCCCTCGGGCGCAGGCAGCTCACACCAGGAAGAGACTGTATTGCAG
 161 GGTGAAGAGTGGGCTCCCGTGGGCCCAGAGCTGCACGCCGGTCCACAGACACACTCACGCCCGCCACCTGCTCCCCGCAG
 241 GATGTGTCTGTGTGTGGGAATTGGTATCTTGCACCCGTGGGAGTCGGGACATATAATGGAAAGGCCCTCGGGAAGTTCCG
 321 CGTCCTCTGTGGGGGCTGCCGGAAGACACGGCCCCAGGAGTCAGGCCCCTGTGGTCAGGTCTAGCATGGGGCTTGTTTTC
 401 CACTCCTGCTGTAAGCAGCCTTCGACACCTGTCCTGCCACGGCCTCCCAGCCGGTGCGGGAGCCCCTCACTGCCCTGACC
 481 GACTCCGCAGTCCCCGGGGAGGAGCATGGATGGTGTGTCGGCAGCTCCGTCCTTCCAGCTGTCCCGTTGCAGTGCCCGTG
 561 ATCCGCGTCTGCCTTAGCAGGGGCCTGCGTGAGTGGGCACGGTGTGGGAGGTCGCCTGCGTGGGGTGGTGTCTGTGTGTG
 641 TGCACGCACGCCTGCCATCAAAGCAGCAGGGCTGAGGGGGTGCAGCTTGCTGGTGTTCACTGGGGGAGGGCCTGTGGGCA
 721 CACATGGCAGAGAGAGTGGCTCACACGTCGTGAGGTCTCCCCTGTGCTCTGGTGACCCGAGGAGGTCGTGCAGCACAGCG
 801 CAGAAGCCCCTGCCCACGGGATCCGGCCCCCCAGACACCGACCCCACAGGCCGTCCCGGATCTCAGCGGACACAGGCAGG
 881 AGCGCCCCATCATTTGACGGTGAGCAGGACTCAGGCTGTGTGTCCTGGAGCTACTTCTCACCAACTGTGGTCAGTGCAGG
 961 GGGAACGAGGAGGTCTTTTGGGGGCCTGGCGAGGGGAAGGGCTGCTGCAGTCTAGGGAGAGGGGGTGCAGCCTGGGGGAT
1041 GTTGGTGGACATGGATGTGGAGGTGGAAGGAGGAGGACGTTGCGTGGAGTGGTGGGAGGAGGCGGGAGCCGTGTGCGAGA
1121 GCAGGTGGAAAGCCTTGAGGGGCAGGACCAGGATGCAGCTGGCTTGTAGAAGAGCTCAGGAGTGAGCCTGGCACTCCAGA
1201 GGGCGCGGCGGGTGGGGAGGCAGCAGGCACCAGTCCAGGAGAGCTTCGTGGACGTGGCTCCTGCGCGCACACCCCCAGGA
1281 GCACAGCCACGGGCTGCAGGTGTGGCTGGCCTCAGCACTCAGTCCTCACCCGGAGCCTTTGCCTGCTCCTCCTTCCAAGA
1361 GCACTGAGGCACCAGTGGGCTTGGCACTCCACCTTGGGCTTCCTTTTCCTGGAGAGCCGCCTTGAGGGTCCCTCCTGTGA
1441 CTGGGGTCTCTGCAGCGAGAGCCGCGGGGGTTGCGGAGCCCCTGCCTGGGGGAGCTGGCGGAATGTGAGCCGCCGGCCGG
1521 GGGCCGCCACATAAGACCTGCAAGGTGGTGCCTGGGGCCCTGGCTCCTTCTCGGCTGCCCCTGCCCACCCAGTAACAGCC
1601 CCCACCAGCTACAGAGCCCAGGCGGGTGCCAGCCACGCTGGGAGGGCAGAGGACAGACAGCCCCGGGGCTGCGACTTGGT
1681 TCTGTGTCTACTGTTAGAAGTTGAGTGGGAAGCTGCAGGCCCGCCAGGACCACTGGGTCCCTACAGAGCAAAGGCCTGCG
1761 TGTTCCCAAACAGCCGTTGCCCCCGTGGCCGTGGTAGGTAATCCATATTGGATGTCATAAGGACCAGGGGGATATTTAAA
1841 GAGAGAAACAGAAAATATATAGAGATATAAAATTATATTCACAGTTTATCTACAGATTTTTCGTAACAATCTTTCTTTTC
1921 CAGTTTGATACTGTAAATCTATCAGAGCAGAGCCGGGGGCACGGGCACAGGTGGGAGTTGGGAGCAAAGCGGAGGCCCGG
2001 GCTGCCCGCCGTCCCCCTTCATCTCCCCACGGACTGTACCAGGCAGCTGGGCCCCGCAGGACAGGCCGCAGCGGGTGGCC
2081 GGTTCTGTCCCGTCTTGGGGTTCTTGGTGTCCACGTCTTGTGGGCCGTGGGCTTCTACCTGCCCTTGGCCTGCAGTGCTT
2161 TGCTGGAGAAGGGACTCCCTGGTCCCCAGGGTGGACGGAGCCGCTGTCACCGCCCAGAGCTGGGCCGGGGAAGCACGGTG
2241 TGTTCTGCTTTTCTTTTCAGATTGTTGAAATTTCATTGTCATGATTTAATATATGGATTTTTTTATTTAAGAAAAAGACG
2321 AGGGACTCTTTGTCACGTGGGTTTGTTTTCTGTCTCCGTGCCTCCGGCTTCCCAAAGAGATCCAGGTCTTTGCGTTTCCA
2401 GGGCGTGGGGACCCCGGCCCCCTATGCCGCCACGCCGCCACACCGCCTCACCCTGGCTTCTGTGCTACTTGGCAGTTCCA
2481 TTTCATTATTTATTTTTTGTGCTGCTTTTTATCATGATATAAATTATTGAAAACAGATCACATGTGGGCCCGTGTCTGGC
2561 CGCCGCCGCCCTGCCCCGTCCCTGCGGCCACCACCTAATTTATTGCCGTGCGTCCTGCTGCTGTGACTGCTTTTGTACCT
2641 TTGCAATAAAGAATTTTCTGGTTTCAGA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' auuucAUUGAA-----GGUGAACCGa 5'
               |::|||     |:||||||| 
Target 5' cacccTGGCTTCTGTGCTACTTGGCa 3'
2449 - 2474 152.00 -13.50
2
miRNA  3' auuuCAUUGAAGGUGAACCGa 5'
              | ::|| | ||||||: 
Target 5' ccccGGGGCTGCGACTTGGTt 3'
1661 - 1681 137.00 -12.70
3
miRNA  3' auUUCAUUG-AAGGUGAACCGa 5'
            |:| | |  |  :|||||| 
Target 5' tgAGGCACCAGTGGGCTTGGCa 3'
1365 - 1386 127.00 -9.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31524544 16 COSMIC
COSN30709439 56 COSMIC
COSN17470017 238 COSMIC
COSN20817893 332 COSMIC
COSN28741127 382 COSMIC
COSN31546202 424 COSMIC
COSN31543680 491 COSMIC
COSN28201137 564 COSMIC
COSN7657830 568 COSMIC
COSN21345078 594 COSMIC
COSN2212747 688 COSMIC
COSN31487720 724 COSMIC
COSN30161544 750 COSMIC
COSN31517332 780 COSMIC
COSN31487595 885 COSMIC
COSN14775205 911 COSMIC
COSN28725504 926 COSMIC
COSN31611024 956 COSMIC
COSN28733334 968 COSMIC
COSN15662542 976 COSMIC
COSN26637469 1026 COSMIC
COSN26641404 1064 COSMIC
COSN8516162 1096 COSMIC
COSN26575162 1114 COSMIC
COSN25069227 1180 COSMIC
COSN15226314 1261 COSMIC
COSN32057063 1527 COSMIC
COSN19722630 1532 COSMIC
COSN31588186 1792 COSMIC
COSN31567911 1855 COSMIC
COSN31589991 1934 COSMIC
COSN30173075 1940 COSMIC
COSN31579447 2041 COSMIC
COSN9980298 2171 COSMIC
COSN24830696 2320 COSMIC
COSN31588646 2378 COSMIC
COSN32063592 2417 COSMIC
COSN19343226 2472 COSMIC
COSN5652953 2489 COSMIC
COSN24301975 2492 COSMIC
COSN26637470 2566 COSMIC
COSN31543374 2566 COSMIC
COSN18723737 2568 COSMIC
COSN27045118 2608 COSMIC
COSN26640038 2636 COSMIC
rs3735656 911 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs766450561 4 dbSNP
rs753620957 5 dbSNP
rs559668774 6 dbSNP
rs1230145609 7 dbSNP
rs764971305 9 dbSNP
rs372751056 10 dbSNP
rs777974954 11 dbSNP
rs1202087490 12 dbSNP
rs757896570 13 dbSNP
rs1160642108 15 dbSNP
rs374770359 15 dbSNP
rs746555332 16 dbSNP
rs1427687440 17 dbSNP
rs747183610 18 dbSNP
rs771233474 18 dbSNP
rs781671062 20 dbSNP
rs1210565892 22 dbSNP
rs1485295138 22 dbSNP
rs574234247 22 dbSNP
rs879087043 22 dbSNP
rs1460509492 24 dbSNP
rs746216163 25 dbSNP
rs770208378 26 dbSNP
rs1406641464 29 dbSNP
rs994750779 30 dbSNP
rs1447786075 31 dbSNP
rs775748199 32 dbSNP
rs1244989884 33 dbSNP
rs749520912 33 dbSNP
rs1400297614 36 dbSNP
rs1478561415 36 dbSNP
rs1279681949 37 dbSNP
rs1427530602 39 dbSNP
rs181353243 40 dbSNP
rs1459555976 42 dbSNP
rs1262451278 44 dbSNP
rs774255082 47 dbSNP
rs1265478473 48 dbSNP
rs1357704233 49 dbSNP
rs896227952 51 dbSNP
rs1388415762 55 dbSNP
rs1298543569 61 dbSNP
rs1364772099 61 dbSNP
rs1437383965 64 dbSNP
rs1380589418 66 dbSNP
rs999999344 67 dbSNP
rs1166482855 75 dbSNP
rs1334427445 83 dbSNP
rs1390431652 85 dbSNP
rs1031520827 89 dbSNP
rs1241985069 92 dbSNP
rs913380196 93 dbSNP
rs955970547 94 dbSNP
rs992627815 96 dbSNP
rs1350557185 99 dbSNP
rs916901386 100 dbSNP
rs1230226715 101 dbSNP
rs1248275322 103 dbSNP
rs1286351157 105 dbSNP
rs1342537301 105 dbSNP
rs1349753634 109 dbSNP
rs969658598 110 dbSNP
rs979746472 111 dbSNP
rs1283649585 112 dbSNP
rs1043270054 113 dbSNP
rs920818434 115 dbSNP
rs1014423795 118 dbSNP
rs1280997073 121 dbSNP
rs926183203 122 dbSNP
rs1371491012 123 dbSNP
rs548138375 125 dbSNP
rs1422347026 126 dbSNP
rs1163302798 127 dbSNP
rs908063160 131 dbSNP
rs1362005438 137 dbSNP
rs1180913555 138 dbSNP
rs1253684083 141 dbSNP
rs1483298457 141 dbSNP
rs944779627 142 dbSNP
rs1489911183 144 dbSNP
rs1289374631 147 dbSNP
rs1252713047 157 dbSNP
rs924720311 169 dbSNP
rs1358491735 170 dbSNP
rs1040502039 175 dbSNP
rs900583881 179 dbSNP
rs931933600 180 dbSNP
rs1043757859 188 dbSNP
rs1351550468 189 dbSNP
rs904415640 195 dbSNP
rs1000144443 197 dbSNP
rs562117228 198 dbSNP
rs530882473 200 dbSNP
rs1014509619 201 dbSNP
rs897642304 204 dbSNP
rs1382132965 206 dbSNP
rs1024024228 212 dbSNP
rs369744704 213 dbSNP
rs1478579912 214 dbSNP
rs994781052 214 dbSNP
rs551070921 215 dbSNP
rs979715375 219 dbSNP
rs373141825 220 dbSNP
rs186206516 222 dbSNP
rs1282229304 223 dbSNP
rs749068603 223 dbSNP
rs983754184 224 dbSNP
rs1411109042 230 dbSNP
rs953248996 235 dbSNP
rs1306134178 236 dbSNP
rs570128063 237 dbSNP
rs944853456 238 dbSNP
rs965522660 239 dbSNP
rs1342971788 241 dbSNP
rs977226864 243 dbSNP
rs1457270312 247 dbSNP
rs760949840 248 dbSNP
rs1174111829 249 dbSNP
rs976661895 254 dbSNP
rs1425608583 255 dbSNP
rs921979884 256 dbSNP
rs763611457 257 dbSNP
rs1192058891 259 dbSNP
rs1479116965 263 dbSNP
rs932070929 265 dbSNP
rs1275592032 267 dbSNP
rs1043726765 268 dbSNP
rs903891250 271 dbSNP
rs935916185 273 dbSNP
rs1270579920 275 dbSNP
rs967968417 276 dbSNP
rs1053004460 277 dbSNP
rs891717407 278 dbSNP
rs376127098 281 dbSNP
rs751432485 286 dbSNP
rs552496312 287 dbSNP
rs926214197 292 dbSNP
rs1201632914 294 dbSNP
rs905603183 295 dbSNP
rs1477889206 298 dbSNP
rs1001266863 307 dbSNP
rs1172685769 308 dbSNP
rs1334697425 309 dbSNP
rs1027267961 310 dbSNP
rs757252936 311 dbSNP
rs983525123 312 dbSNP
rs1395122620 313 dbSNP
rs1168121624 315 dbSNP
rs1036506192 316 dbSNP
rs780953176 317 dbSNP
rs1249964494 318 dbSNP
rs897551832 319 dbSNP
rs1325407277 320 dbSNP
rs966706676 322 dbSNP
rs1329182737 323 dbSNP
rs1048893347 325 dbSNP
rs778601930 325 dbSNP
rs1228681301 328 dbSNP
rs1343755409 329 dbSNP
rs1007472872 331 dbSNP
rs1298647959 331 dbSNP
rs1379846617 332 dbSNP
rs1018302795 333 dbSNP
rs901150916 341 dbSNP
rs566019667 342 dbSNP
rs998173162 343 dbSNP
rs1392142903 344 dbSNP
rs1162803191 346 dbSNP
rs1250888795 347 dbSNP
rs922117445 348 dbSNP
rs1415171473 349 dbSNP
rs1212195754 350 dbSNP
rs1482318698 351 dbSNP
rs534923263 352 dbSNP
rs1251530451 370 dbSNP
rs554218271 372 dbSNP
rs1483817167 373 dbSNP
rs1468339665 379 dbSNP
rs755890707 380 dbSNP
rs747766733 381 dbSNP
rs574393322 384 dbSNP
rs1451001938 386 dbSNP
rs1186271708 387 dbSNP
rs958982236 388 dbSNP
rs979553696 393 dbSNP
rs925363700 396 dbSNP
rs992139084 402 dbSNP
rs1411385716 407 dbSNP
rs1372665410 408 dbSNP
rs1291943984 410 dbSNP
rs916947757 411 dbSNP
rs779145453 414 dbSNP
rs935314452 416 dbSNP
rs1052877452 424 dbSNP
rs138698752 425 dbSNP
rs1023588854 428 dbSNP
rs1388437735 429 dbSNP
rs1208804847 430 dbSNP
rs191905624 432 dbSNP
rs577021246 434 dbSNP
rs1048957319 435 dbSNP
rs888936381 441 dbSNP
rs950034052 442 dbSNP
rs1045530359 444 dbSNP
rs546031038 447 dbSNP
rs943288640 449 dbSNP
rs905738182 453 dbSNP
rs1001235830 454 dbSNP
rs369405233 458 dbSNP
rs887533047 459 dbSNP
rs1020243727 463 dbSNP
rs903317145 467 dbSNP
rs1004523056 469 dbSNP
rs1455677929 471 dbSNP
rs1015021557 472 dbSNP
rs1033170030 473 dbSNP
rs1160486175 475 dbSNP
rs966300999 481 dbSNP
rs772691050 482 dbSNP
rs1376267444 487 dbSNP
rs573154061 493 dbSNP
rs1268968124 494 dbSNP
rs1186149206 496 dbSNP
rs542140638 497 dbSNP
rs991651480 500 dbSNP
rs1209889651 502 dbSNP
rs1210506566 504 dbSNP
rs1024993543 505 dbSNP
rs971640913 508 dbSNP
rs561900730 520 dbSNP
rs1184456390 521 dbSNP
rs1305845337 529 dbSNP
rs530968333 530 dbSNP
rs10714927 533 dbSNP
rs1364467689 533 dbSNP
rs979604454 534 dbSNP
rs1188941792 542 dbSNP
rs1384395221 546 dbSNP
rs1466829022 547 dbSNP
rs925329090 547 dbSNP
rs930407076 549 dbSNP
rs1166254377 550 dbSNP
rs984518289 555 dbSNP
rs910279199 556 dbSNP
rs544356830 558 dbSNP
rs988142823 559 dbSNP
rs1390615337 563 dbSNP
rs943209662 565 dbSNP
rs917941981 566 dbSNP
rs923182858 567 dbSNP
rs949988480 574 dbSNP
rs142847928 579 dbSNP
rs1341603023 586 dbSNP
rs532335843 586 dbSNP
rs1403136434 588 dbSNP
rs114852016 589 dbSNP
rs565881423 590 dbSNP
rs770257652 593 dbSNP
rs903179485 594 dbSNP
rs1334019511 600 dbSNP
rs1000260687 601 dbSNP
rs528364464 602 dbSNP
rs1229587267 614 dbSNP
rs548477386 615 dbSNP
rs1367837539 616 dbSNP
rs1290728331 620 dbSNP
rs567943352 621 dbSNP
rs1048894473 624 dbSNP
rs1013511189 633 dbSNP
rs1215469576 633 dbSNP
rs778061674 633 dbSNP
rs887510575 635 dbSNP
rs1259787893 642 dbSNP
rs1483339626 645 dbSNP
rs537098686 646 dbSNP
rs1036014279 647 dbSNP
rs1197638343 648 dbSNP
rs901546873 650 dbSNP
rs993749534 651 dbSNP
rs1389473293 655 dbSNP
rs1485042142 656 dbSNP
rs1246145158 657 dbSNP
rs1026007427 666 dbSNP
rs12671303 670 dbSNP
rs879826662 671 dbSNP
rs1286817785 675 dbSNP
rs1409558254 676 dbSNP
rs1370811084 677 dbSNP
rs1330409750 681 dbSNP
rs556773911 686 dbSNP
rs1389386366 692 dbSNP
rs1029216037 700 dbSNP
rs1182873473 701 dbSNP
rs1414035836 705 dbSNP
rs1476127367 710 dbSNP
rs1409607131 711 dbSNP
rs1181209580 713 dbSNP
rs146094890 714 dbSNP
rs1158025230 715 dbSNP
rs1252817718 719 dbSNP
rs1206884318 721 dbSNP
rs1377971424 722 dbSNP
rs747502968 726 dbSNP
rs1301283306 729 dbSNP
rs1211003577 736 dbSNP
rs528358447 746 dbSNP
rs1410460484 747 dbSNP
rs1228180633 748 dbSNP
rs1310419551 750 dbSNP
rs766422603 751 dbSNP
rs1330056652 756 dbSNP
rs1001013017 757 dbSNP
rs1323677302 758 dbSNP
rs771612234 767 dbSNP
rs796302928 768 dbSNP
rs1032537741 775 dbSNP
rs577929484 779 dbSNP
rs964452780 780 dbSNP
rs976358869 788 dbSNP
rs923123481 789 dbSNP
rs1314305413 790 dbSNP
rs537523946 793 dbSNP
rs1194363397 797 dbSNP
rs1024971526 800 dbSNP
rs971095235 801 dbSNP
rs1208650733 802 dbSNP
rs980745441 804 dbSNP
rs1205206827 806 dbSNP
rs1253898552 809 dbSNP
rs1479587264 813 dbSNP
rs927181865 816 dbSNP
rs925178821 818 dbSNP
rs754134167 819 dbSNP
rs1434677010 820 dbSNP
rs140001708 825 dbSNP
rs1275012719 826 dbSNP
rs979008690 830 dbSNP
rs894568924 832 dbSNP
rs1430521548 833 dbSNP
rs909066501 836 dbSNP
rs1013002551 837 dbSNP
rs1170513835 838 dbSNP
rs1346786947 840 dbSNP
rs1336070262 841 dbSNP
rs1046347367 845 dbSNP
rs907349214 846 dbSNP
rs1424739714 850 dbSNP
rs940443150 852 dbSNP
rs994046011 853 dbSNP
rs776029527 854 dbSNP
rs901602019 857 dbSNP
rs373339790 858 dbSNP
rs573118960 859 dbSNP
rs1208475556 861 dbSNP
rs1050106961 868 dbSNP
rs117730393 869 dbSNP
rs1300807457 874 dbSNP
rs1339515777 876 dbSNP
rs1296184494 878 dbSNP
rs1001148255 884 dbSNP
rs376966808 885 dbSNP
rs1300951209 886 dbSNP
rs556052802 887 dbSNP
rs567840641 888 dbSNP
rs1447022221 890 dbSNP
rs764481404 892 dbSNP
rs1305257085 893 dbSNP
rs116976138 894 dbSNP
rs1265901520 895 dbSNP
rs970848146 899 dbSNP
rs748568283 901 dbSNP
rs1489344306 902 dbSNP
rs1429134738 903 dbSNP
rs1422271319 904 dbSNP
rs1191475234 909 dbSNP
rs3735656 911 dbSNP
rs1033664792 913 dbSNP
rs1258628639 915 dbSNP
rs1190719203 918 dbSNP
rs564480799 931 dbSNP
rs966588526 932 dbSNP
rs1273405404 938 dbSNP
rs1204625514 940 dbSNP
rs1308680546 943 dbSNP
rs762518594 946 dbSNP
rs1417542258 954 dbSNP
rs1310570242 962 dbSNP
rs984705516 964 dbSNP
rs112812160 967 dbSNP
rs977868045 968 dbSNP
rs940486380 974 dbSNP
rs1407725984 975 dbSNP
rs1368960727 977 dbSNP
rs1307578063 980 dbSNP
rs971936851 981 dbSNP
rs922991414 985 dbSNP
rs1325587839 986 dbSNP
rs143615402 991 dbSNP
rs1435453841 992 dbSNP
rs1471782221 997 dbSNP
rs1050077008 1001 dbSNP
rs1359274271 1004 dbSNP
rs1177422919 1005 dbSNP
rs1213411639 1008 dbSNP
rs888820059 1026 dbSNP
rs559553950 1031 dbSNP
rs1220800903 1032 dbSNP
rs773910538 1033 dbSNP
rs1054405520 1035 dbSNP
rs892725095 1037 dbSNP
rs1349645580 1038 dbSNP
rs1010118134 1052 dbSNP
rs948839351 1053 dbSNP
rs1375667441 1054 dbSNP
rs1272362727 1055 dbSNP
rs528327413 1060 dbSNP
rs907250788 1062 dbSNP
rs1395874284 1065 dbSNP
rs548186949 1074 dbSNP
rs568385725 1076 dbSNP
rs1047887077 1078 dbSNP
rs1159450074 1079 dbSNP
rs150895606 1080 dbSNP
rs375933520 1084 dbSNP
rs1264783991 1096 dbSNP
rs1033632235 1097 dbSNP
rs888067818 1100 dbSNP
rs1254881857 1101 dbSNP
rs1164834254 1102 dbSNP
rs1389916620 1104 dbSNP
rs1328275790 1110 dbSNP
rs115035215 1112 dbSNP
rs1319888121 1113 dbSNP
rs761718659 1117 dbSNP
rs111601093 1118 dbSNP
rs997567565 1134 dbSNP
rs966830566 1140 dbSNP
rs1433503543 1145 dbSNP
rs977900490 1146 dbSNP
rs535212367 1150 dbSNP
rs1455628555 1151 dbSNP
rs957983673 1152 dbSNP
rs570135771 1155 dbSNP
rs1174905803 1157 dbSNP
rs183229226 1163 dbSNP
rs1231449004 1169 dbSNP
rs1396338780 1186 dbSNP
rs972291006 1193 dbSNP
rs923161157 1197 dbSNP
rs1464410758 1202 dbSNP
rs1262281625 1204 dbSNP
rs552685747 1205 dbSNP
rs1482115437 1206 dbSNP
rs985920111 1207 dbSNP
rs910308363 1208 dbSNP
rs936286082 1210 dbSNP
rs566701030 1211 dbSNP
rs928738762 1213 dbSNP
rs988778106 1214 dbSNP
rs370456550 1215 dbSNP
rs929373034 1217 dbSNP
rs911941007 1219 dbSNP
rs374061657 1221 dbSNP
rs887932291 1224 dbSNP
rs1211055713 1231 dbSNP
rs1376853051 1232 dbSNP
rs942284880 1235 dbSNP
rs945671929 1240 dbSNP
rs1484726684 1248 dbSNP
rs1195234885 1249 dbSNP
rs1187887862 1254 dbSNP
rs575853503 1255 dbSNP
rs767691957 1258 dbSNP
rs1157144784 1261 dbSNP
rs997201464 1262 dbSNP
rs1030374092 1265 dbSNP
rs538157453 1266 dbSNP
rs750499437 1267 dbSNP
rs1055100550 1268 dbSNP
rs888544434 1270 dbSNP
rs1376809153 1271 dbSNP
rs1305724344 1272 dbSNP
rs1356990311 1272 dbSNP
rs1408932330 1273 dbSNP
rs1005942291 1284 dbSNP
rs1169629427 1285 dbSNP
rs756311585 1289 dbSNP
rs1023558093 1291 dbSNP
rs971010799 1292 dbSNP
rs1312202850 1293 dbSNP
rs1259885621 1297 dbSNP
rs1350987871 1298 dbSNP
rs1180267753 1299 dbSNP
rs1197587087 1301 dbSNP
rs189233879 1301 dbSNP
rs1354889317 1303 dbSNP
rs1273040217 1306 dbSNP
rs962259352 1308 dbSNP
rs993464434 1311 dbSNP
rs1030169247 1312 dbSNP
rs928617814 1316 dbSNP
rs950805708 1323 dbSNP
rs954490024 1325 dbSNP
rs1286134663 1328 dbSNP
rs578080312 1332 dbSNP
rs377278610 1333 dbSNP
rs139402822 1338 dbSNP
rs1384521589 1345 dbSNP
rs560617133 1349 dbSNP
rs957827752 1355 dbSNP
rs989530270 1358 dbSNP
rs1165482308 1359 dbSNP
rs766092208 1365 dbSNP
rs913596378 1366 dbSNP
rs922213580 1369 dbSNP
rs933568597 1370 dbSNP
rs1469844136 1373 dbSNP
rs1233617060 1374 dbSNP
rs1184092895 1375 dbSNP
rs1051475922 1376 dbSNP
rs902176985 1379 dbSNP
rs111764525 1390 dbSNP
rs1345828965 1394 dbSNP
rs1210206577 1395 dbSNP
rs1350975998 1399 dbSNP
rs1280871554 1403 dbSNP
rs1230448360 1404 dbSNP
rs1046682942 1409 dbSNP
rs1326548302 1410 dbSNP
rs1253198444 1412 dbSNP
rs893520626 1414 dbSNP
rs538214080 1419 dbSNP
rs190852165 1420 dbSNP
rs1408989968 1422 dbSNP
rs1160507333 1428 dbSNP
rs764119857 1443 dbSNP
rs1394535349 1444 dbSNP
rs777974625 1447 dbSNP
rs1470246594 1448 dbSNP
rs970702676 1449 dbSNP
rs1215541025 1454 dbSNP
rs541970164 1458 dbSNP
rs561740066 1464 dbSNP
rs530805753 1466 dbSNP
rs1005665038 1467 dbSNP
rs1184691945 1472 dbSNP
rs983421909 1475 dbSNP
rs754873584 1476 dbSNP
rs963420240 1480 dbSNP
rs1346731893 1481 dbSNP
rs1326758782 1483 dbSNP
rs1320588784 1486 dbSNP
rs974980379 1493 dbSNP
rs922087401 1500 dbSNP
rs117548665 1501 dbSNP
rs1455602004 1505 dbSNP
rs10226620 1507 dbSNP
rs532794089 1508 dbSNP
rs182310645 1512 dbSNP
rs1233816114 1513 dbSNP
rs890389679 1515 dbSNP
rs935003823 1516 dbSNP
rs1341557039 1518 dbSNP
rs1280525977 1519 dbSNP
rs186576927 1520 dbSNP
rs1339438604 1522 dbSNP
rs893596249 1523 dbSNP
rs1215067173 1525 dbSNP
rs1017470300 1526 dbSNP
rs535206487 1532 dbSNP
rs1355078988 1536 dbSNP
rs1313645743 1538 dbSNP
rs958014495 1540 dbSNP
rs1436740610 1542 dbSNP
rs544988060 1545 dbSNP
rs747946345 1549 dbSNP
rs989279339 1551 dbSNP
rs1021036557 1557 dbSNP
rs906339638 1572 dbSNP
rs150069281 1573 dbSNP
rs569370389 1574 dbSNP
rs1257870511 1580 dbSNP
rs1189606795 1588 dbSNP
rs1479400148 1589 dbSNP
rs113587702 1599 dbSNP
rs928197319 1601 dbSNP
rs1309211302 1613 dbSNP
rs1271133893 1617 dbSNP
rs1232464436 1618 dbSNP
rs938289584 1624 dbSNP
rs1294202106 1625 dbSNP
rs1004889926 1628 dbSNP
rs1371401132 1631 dbSNP
rs1297699870 1637 dbSNP
rs1442944791 1639 dbSNP
rs990936134 1650 dbSNP
rs1163388726 1653 dbSNP
rs1461311864 1659 dbSNP
rs1418990649 1662 dbSNP
rs746504491 1664 dbSNP
rs1416962744 1666 dbSNP
rs910089612 1673 dbSNP
rs1405766380 1674 dbSNP
rs867292875 1677 dbSNP
rs558520116 1684 dbSNP
rs1481293764 1685 dbSNP
rs770381969 1688 dbSNP
rs1212982395 1693 dbSNP
rs975221227 1694 dbSNP
rs1236569214 1706 dbSNP
rs1315358671 1710 dbSNP
rs1306492437 1718 dbSNP
rs1224464386 1720 dbSNP
rs941442613 1723 dbSNP
rs1037081013 1724 dbSNP
rs1440790597 1727 dbSNP
rs1440530169 1729 dbSNP
rs1328381935 1732 dbSNP
rs1298592137 1736 dbSNP
rs1362874382 1737 dbSNP
rs897241968 1742 dbSNP
rs578054092 1744 dbSNP
rs534228297 1750 dbSNP
rs1192979976 1753 dbSNP
rs987620812 1760 dbSNP
rs776152453 1761 dbSNP
rs1270159906 1776 dbSNP
rs560256315 1777 dbSNP
rs1007508825 1783 dbSNP
rs574034027 1785 dbSNP
rs542779508 1786 dbSNP
rs1356009589 1787 dbSNP
rs145347546 1791 dbSNP
rs575384797 1792 dbSNP
rs368835704 1818 dbSNP
rs1020667353 1825 dbSNP
rs1261917592 1826 dbSNP
rs544081901 1830 dbSNP
rs966881315 1832 dbSNP
rs1190339045 1840 dbSNP
rs981725934 1846 dbSNP
rs1371980117 1848 dbSNP
rs1373204138 1850 dbSNP
rs191164663 1850 dbSNP
rs1172485417 1852 dbSNP
rs939191459 1858 dbSNP
rs1167005998 1860 dbSNP
rs138130049 1862 dbSNP
rs776496247 1862 dbSNP
rs1190933723 1869 dbSNP
rs959608750 1872 dbSNP
rs1427748422 1873 dbSNP
rs887065646 1876 dbSNP
rs991073532 1877 dbSNP
rs750094942 1878 dbSNP
rs1321473640 1887 dbSNP
rs371792473 1892 dbSNP
rs1016304880 1903 dbSNP
rs746378437 1904 dbSNP
rs941506209 1906 dbSNP
rs973326092 1910 dbSNP
rs1225831975 1911 dbSNP
rs1029496906 1914 dbSNP
rs918653801 1916 dbSNP
rs1296763211 1933 dbSNP
rs934086399 1937 dbSNP
rs371602175 1939 dbSNP
rs560858322 1942 dbSNP
rs1031119850 1945 dbSNP
rs1166139431 1955 dbSNP
rs1434873525 1955 dbSNP
rs747570386 1955 dbSNP
rs889825251 1956 dbSNP
rs1291959326 1960 dbSNP
rs142578618 1962 dbSNP
rs559895233 1963 dbSNP
rs1038928861 1964 dbSNP
rs1260971659 1974 dbSNP
rs1187489262 1979 dbSNP
rs893721219 1985 dbSNP
rs1258320121 1988 dbSNP
rs915469305 1991 dbSNP
rs144263130 1992 dbSNP
rs980430161 1999 dbSNP
rs1485705478 2000 dbSNP
rs1292341827 2002 dbSNP
rs1189999293 2005 dbSNP
rs147798572 2009 dbSNP
rs939113466 2011 dbSNP
rs902248149 2012 dbSNP
rs886929884 2024 dbSNP
rs941283785 2026 dbSNP
rs1003280890 2031 dbSNP
rs1416853730 2032 dbSNP
rs1164538189 2034 dbSNP
rs1475668966 2035 dbSNP
rs1370373437 2041 dbSNP
rs1234611219 2045 dbSNP
rs1034647763 2047 dbSNP
rs569416337 2048 dbSNP
rs958994283 2055 dbSNP
rs879650991 2056 dbSNP
rs1011877743 2057 dbSNP
rs796713524 2059 dbSNP
rs996580888 2067 dbSNP
rs1403069789 2068 dbSNP
rs367917142 2069 dbSNP
rs1028991082 2071 dbSNP
rs890568480 2073 dbSNP
rs762124325 2074 dbSNP
rs1335826404 2079 dbSNP
rs10276767 2081 dbSNP
rs918776611 2082 dbSNP
rs1309660308 2083 dbSNP
rs955431584 2090 dbSNP
rs1315503110 2091 dbSNP
rs986921318 2093 dbSNP
rs1259723154 2097 dbSNP
rs1347979791 2098 dbSNP
rs911312111 2108 dbSNP
rs956887391 2115 dbSNP
rs767757142 2116 dbSNP
rs942642757 2121 dbSNP
rs1011001483 2122 dbSNP
rs1252847607 2123 dbSNP
rs1255346579 2127 dbSNP
rs1054876565 2128 dbSNP
rs1485330840 2128 dbSNP
rs915145535 2131 dbSNP
rs1204154747 2136 dbSNP
rs946654878 2138 dbSNP
rs1310840590 2144 dbSNP
rs1231381511 2145 dbSNP
rs1370159103 2149 dbSNP
rs1042215603 2160 dbSNP
rs1482311682 2169 dbSNP
rs1438434051 2180 dbSNP
rs902394968 2184 dbSNP
rs1003336351 2185 dbSNP
rs1022978396 2188 dbSNP
rs11544235 2191 dbSNP
rs1316566292 2196 dbSNP
rs768347471 2197 dbSNP
rs1056109943 2198 dbSNP
rs894912680 2203 dbSNP
rs141094326 2204 dbSNP
rs1417066094 2209 dbSNP
rs1017034429 2212 dbSNP
rs962977949 2213 dbSNP
rs571930804 2215 dbSNP
rs534501089 2221 dbSNP
rs554183174 2227 dbSNP
rs761262669 2228 dbSNP
rs534494825 2231 dbSNP
rs1447250319 2234 dbSNP
rs1374898301 2236 dbSNP
rs184925068 2237 dbSNP
rs1208114751 2238 dbSNP
rs1300404969 2238 dbSNP
rs1346520955 2243 dbSNP
rs1038168667 2244 dbSNP
rs911279517 2260 dbSNP
rs1220855724 2261 dbSNP
rs932575345 2263 dbSNP
rs536735429 2264 dbSNP
rs1050884751 2269 dbSNP
rs1431110153 2276 dbSNP
rs766948264 2280 dbSNP
rs556411500 2284 dbSNP
rs890442865 2291 dbSNP
rs1236010041 2293 dbSNP
rs914591462 2294 dbSNP
rs1177483906 2296 dbSNP
rs1346512853 2298 dbSNP
rs1205200169 2315 dbSNP
rs143452198 2320 dbSNP
rs544041187 2321 dbSNP
rs1052485327 2325 dbSNP
rs1253374772 2327 dbSNP
rs892518020 2329 dbSNP
rs1485088756 2330 dbSNP
rs1011032680 2331 dbSNP
rs1022460054 2337 dbSNP
rs557539077 2338 dbSNP
rs1215005545 2340 dbSNP
rs1252864662 2341 dbSNP
rs1042661576 2351 dbSNP
rs970079019 2357 dbSNP
rs923869466 2358 dbSNP
rs939160175 2359 dbSNP
rs56780119 2363 dbSNP
rs894878128 2366 dbSNP
rs1490256802 2368 dbSNP
rs947822388 2369 dbSNP
rs1038031315 2373 dbSNP
rs982418089 2376 dbSNP
rs1163168245 2378 dbSNP
rs1474694783 2384 dbSNP
rs898192749 2386 dbSNP
rs1189644618 2387 dbSNP
rs993850692 2394 dbSNP
rs1026280960 2395 dbSNP
rs1479365011 2399 dbSNP
rs891397360 2405 dbSNP
rs540158147 2406 dbSNP
rs560057809 2410 dbSNP
rs1008375736 2413 dbSNP
rs974345240 2416 dbSNP
rs1271060332 2417 dbSNP
rs1018483897 2422 dbSNP
rs1051038467 2426 dbSNP
rs964116991 2429 dbSNP
rs527779220 2430 dbSNP
rs1448200324 2434 dbSNP
rs1324307896 2435 dbSNP
rs944716548 2435 dbSNP
rs1397102458 2436 dbSNP
rs766179267 2437 dbSNP
rs1427375652 2438 dbSNP
rs528913173 2442 dbSNP
rs1300786191 2443 dbSNP
rs1406578322 2444 dbSNP
rs1178662809 2445 dbSNP
rs1441499246 2446 dbSNP
rs542683052 2457 dbSNP
rs1044517 2458 dbSNP
rs542819255 2464 dbSNP
rs923838333 2465 dbSNP
rs1224025534 2476 dbSNP
rs758659499 2481 dbSNP
rs905343252 2486 dbSNP
rs1240881998 2493 dbSNP
rs1379781202 2494 dbSNP
rs1273657660 2503 dbSNP
rs1440719569 2515 dbSNP
rs1368708877 2518 dbSNP
rs991938330 2526 dbSNP
rs1002762172 2535 dbSNP
rs1212070180 2541 dbSNP
rs1451203631 2546 dbSNP
rs116258531 2551 dbSNP
rs551960123 2552 dbSNP
rs1038486256 2553 dbSNP
rs764374615 2562 dbSNP
rs1428483912 2563 dbSNP
rs751855463 2565 dbSNP
rs1420542916 2566 dbSNP
rs1046781992 2567 dbSNP
rs962480073 2568 dbSNP
rs147989683 2569 dbSNP
rs1278865975 2575 dbSNP
rs1028466448 2576 dbSNP
rs757357421 2578 dbSNP
rs527958861 2579 dbSNP
rs55961916 2583 dbSNP
rs548143137 2585 dbSNP
rs899961470 2586 dbSNP
rs1011757057 2587 dbSNP
rs1373060888 2588 dbSNP
rs1172424918 2589 dbSNP
rs781140274 2590 dbSNP
rs1044528 2591 dbSNP
rs1379233982 2591 dbSNP
rs1168081045 2592 dbSNP
rs1044529 2594 dbSNP
rs746381685 2596 dbSNP
rs977809490 2597 dbSNP
rs1489339630 2599 dbSNP
rs1035680221 2602 dbSNP
rs960602316 2608 dbSNP
rs532461313 2609 dbSNP
rs1044533 2612 dbSNP
rs556609445 2613 dbSNP
rs1317676761 2617 dbSNP
rs1043837120 2619 dbSNP
rs1353140433 2620 dbSNP
rs1332940308 2622 dbSNP
rs570011761 2623 dbSNP
rs11544234 2628 dbSNP
rs916499334 2631 dbSNP
rs938203533 2631 dbSNP
rs1404340858 2640 dbSNP
rs1240498518 2650 dbSNP
rs1485576512 2652 dbSNP
rs1189281815 2654 dbSNP
rs947845324 2656 dbSNP
rs1057028815 2657 dbSNP
rs3177192 2659 dbSNP
rs3180965 2668 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' auuucauUGAAGGU-GAACCga 5'
                 || |||| |||||  
Target 5' ------cAC-UCCACCUUGGgc 3'
1 - 15
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' auuucauUGAAGGU-GAACCga 5'
                 || |||| |||||  
Target 5' ------cAC-UCCACCUUGGgc 3'
1 - 15
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated ...

- Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology.

Article - Farazi TA; Ten Hoeve JJ; Brown M; et al.
- Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
Experimental Support 4 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177624. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_4_2 PAR-CLIP data was present in ERX177610. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_2_12 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
CLIP-seq Support 1 for dataset GSM545217
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-7 transfection
Location of target site ENST00000343242.4 | 3UTR | CACUCCACCUUGGGCUUCCUUUUCCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset SRR1045082
Method / RBP PAR-CLIP / AGO2
Cell line / Condition MCF7 / Untreated
Location of target site ENST00000343242.4 | 3UTR | CACUCCACCUUGGGCUUCCUUUUCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24398324 / SRX388831
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000343242.4 | 3UTR | CACUCCACCUUGGGCUUCCUUUUCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
117 hsa-miR-4480 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT056040 MLLT10 MLLT10, histone lysine methyltransferase DOT1L cofactor 2 2
MIRT091259 FXR1 FMR1 autosomal homolog 1 2 4
MIRT117347 MAPRE2 microtubule associated protein RP/EB family member 2 2 2
MIRT234960 ZNF439 zinc finger protein 439 2 4
MIRT441356 ZNF75A zinc finger protein 75a 2 2
MIRT441426 STXBP2 syntaxin binding protein 2 2 2
MIRT441455 ZNF488 zinc finger protein 488 2 4
MIRT441524 ZBTB10 zinc finger and BTB domain containing 10 2 2
MIRT441576 EXOC5 exocyst complex component 5 2 2
MIRT441597 ABCB5 ATP binding cassette subfamily B member 5 2 6
MIRT441610 ATP13A4 ATPase 13A4 2 2
MIRT441698 CIT citron rho-interacting serine/threonine kinase 2 2
MIRT441714 FGF9 fibroblast growth factor 9 2 2
MIRT441784 MAPK8 mitogen-activated protein kinase 8 2 4
MIRT441795 EXOSC2 exosome component 2 2 2
MIRT441868 RNASEL ribonuclease L 2 2
MIRT441900 SLC9A8 solute carrier family 9 member A8 2 6
MIRT441919 FAM217B family with sequence similarity 217 member B 2 2
MIRT441928 C1orf109 chromosome 1 open reading frame 109 2 2
MIRT441938 RIMKLB ribosomal modification protein rimK like family member B 2 2
MIRT442157 DPY19L1 dpy-19 like C-mannosyltransferase 1 2 2
MIRT442172 AZF1 azoospermia factor 1 2 2
MIRT442208 IRS1 insulin receptor substrate 1 2 2
MIRT442237 DDX19A DEAD-box helicase 19A 2 2
MIRT442366 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT442572 SDC1 syndecan 1 2 2
MIRT442604 ZNF391 zinc finger protein 391 2 2
MIRT442609 MRC1 mannose receptor C-type 1 2 2
MIRT442647 POP4 POP4 homolog, ribonuclease P/MRP subunit 2 2
MIRT442658 OIP5 Opa interacting protein 5 2 6
MIRT442686 COX15 COX15, cytochrome c oxidase assembly homolog 2 2
MIRT442773 JAG1 jagged 1 2 2
MIRT442785 CHD8 chromodomain helicase DNA binding protein 8 2 2
MIRT442895 PLCB3 phospholipase C beta 3 2 2
MIRT442941 C17orf105 chromosome 17 open reading frame 105 2 2
MIRT442959 SGCD sarcoglycan delta 2 2
MIRT442998 EDAR ectodysplasin A receptor 2 2
MIRT443017 C21orf91 chromosome 21 open reading frame 91 2 2
MIRT443064 CASP5 caspase 5 2 2
MIRT443069 ABLIM1 actin binding LIM protein 1 2 2
MIRT443208 VPS36 vacuolar protein sorting 36 homolog 2 2
MIRT443237 ANKRD26 ankyrin repeat domain 26 2 2
MIRT443253 A1CF APOBEC1 complementation factor 2 2
MIRT443329 JUN Jun proto-oncogene, AP-1 transcription factor subunit 2 2
MIRT443333 NRAS NRAS proto-oncogene, GTPase 2 2
MIRT443349 STX7 syntaxin 7 2 2
MIRT443452 CLIC5 chloride intracellular channel 5 2 2
MIRT443547 GPR35 G protein-coupled receptor 35 2 2
MIRT443616 AVPR1A arginine vasopressin receptor 1A 2 2
MIRT443626 CPSF2 cleavage and polyadenylation specific factor 2 2 2
MIRT443730 ALPK3 alpha kinase 3 2 2
MIRT443786 ST13 ST13, Hsp70 interacting protein 2 2
MIRT443852 RGS6 regulator of G protein signaling 6 2 2
MIRT445483 KLF5 Kruppel like factor 5 2 2
MIRT471105 PHLDA2 pleckstrin homology like domain family A member 2 2 2
MIRT472329 NETO2 neuropilin and tolloid like 2 2 4
MIRT472391 NDRG3 NDRG family member 3 2 2
MIRT473522 MAX MYC associated factor X 2 2
MIRT473874 MAFK MAF bZIP transcription factor K 2 6
MIRT476021 GTF2A1 general transcription factor IIA subunit 1 2 2
MIRT478320 DDN dendrin 2 2
MIRT492049 TNFSF9 TNF superfamily member 9 2 2
MIRT494851 ANKRD24 ankyrin repeat domain 24 2 2
MIRT494991 TSSC1 EARP complex and GARP complex interacting protein 1 2 2
MIRT495034 RASSF2 Ras association domain family member 2 2 2
MIRT495111 NOL10 nucleolar protein 10 2 2
MIRT495113 TRADD TNFRSF1A associated via death domain 2 2
MIRT495131 METTL24 methyltransferase like 24 2 2
MIRT495147 STAC2 SH3 and cysteine rich domain 2 2 2
MIRT495297 NUP54 nucleoporin 54 2 2
MIRT495341 RTN2 reticulon 2 2 2
MIRT495347 ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B) 2 2
MIRT496682 DUSP18 dual specificity phosphatase 18 2 2
MIRT496743 TGFBR1 transforming growth factor beta receptor 1 2 2
MIRT496841 KCNIP2 potassium voltage-gated channel interacting protein 2 2 2
MIRT496852 GPAM glycerol-3-phosphate acyltransferase, mitochondrial 2 2
MIRT496889 FOXP1 forkhead box P1 2 2
MIRT496922 CLMN calmin 2 2
MIRT496990 TMEM231 transmembrane protein 231 2 2
MIRT497002 SNAP25 synaptosome associated protein 25 2 2
MIRT497058 C6orf223 chromosome 6 open reading frame 223 2 2
MIRT500529 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 6
MIRT506048 PPP6C protein phosphatase 6 catalytic subunit 2 4
MIRT512163 CD164 CD164 molecule 2 6
MIRT527051 RDH13 retinol dehydrogenase 13 2 2
MIRT532282 TNFSF14 TNF superfamily member 14 2 2
MIRT534083 SPRY4 sprouty RTK signaling antagonist 4 2 2
MIRT534605 RNASEH1 ribonuclease H1 2 4
MIRT539509 ACSS3 acyl-CoA synthetase short chain family member 3 2 2
MIRT543069 ARID4B AT-rich interaction domain 4B 2 2
MIRT544233 CCBL2 kynurenine aminotransferase 3 2 2
MIRT544686 ZNF224 zinc finger protein 224 2 4
MIRT546269 TMEM30A transmembrane protein 30A 2 4
MIRT559069 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT562768 RMI2 RecQ mediated genome instability 2 2 2
MIRT563974 HCFC1 host cell factor C1 2 2
MIRT564086 NSA2 NSA2, ribosome biogenesis homolog 2 2
MIRT564525 PDXP pyridoxal phosphatase 2 2
MIRT564613 ZNF703 zinc finger protein 703 2 2
MIRT566252 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT614420 ZNF440 zinc finger protein 440 2 2
MIRT618789 MTHFR methylenetetrahydrofolate reductase 2 2
MIRT619160 PPDPF pancreatic progenitor cell differentiation and proliferation factor 2 2
MIRT641778 ZDHHC7 zinc finger DHHC-type containing 7 2 4
MIRT653680 SLC25A36 solute carrier family 25 member 36 2 2
MIRT657861 GJD2 gap junction protein delta 2 2 2
MIRT660879 ADCYAP1R1 ADCYAP receptor type I 2 2
MIRT668781 DAAM1 dishevelled associated activator of morphogenesis 1 2 4
MIRT688559 DCAF16 DDB1 and CUL4 associated factor 16 2 2
MIRT695393 WDR41 WD repeat domain 41 2 2
MIRT698680 TCEA1 transcription elongation factor A1 2 2
MIRT700974 PDIA6 protein disulfide isomerase family A member 6 2 2
MIRT705055 C5orf15 chromosome 5 open reading frame 15 2 2
MIRT705864 AFF1 AF4/FMR2 family member 1 2 2
MIRT710586 CDCA4 cell division cycle associated 4 2 2
MIRT713904 IGF2R insulin like growth factor 2 receptor 2 2
MIRT717133 SKI SKI proto-oncogene 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4480 Cisplatin 5460033 NSC119875 approved sensitive cell line (CIS)
hsa-miR-4480 Cisplatin 5460033 NSC119875 approved resistant cell line (A549)

Error report submission