pre-miRNA Information
pre-miRNA hsa-mir-4433a   
Genomic Coordinates chr2: 64340759 - 64340839
Description Homo sapiens miR-4433a stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4433a-3p
Sequence 51| ACAGGAGUGGGGGUGGGACAU |71
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs751480515 9 dbSNP
rs557760377 15 dbSNP
rs1479580865 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol LONRF1   
Synonyms RNF191
Description LON peptidase N-terminal domain and ring finger 1
Transcript NM_152271   
Expression
Putative miRNA Targets on LONRF1
3'UTR of LONRF1
(miRNA target sites are highlighted)
>LONRF1|NM_152271|3'UTR
   1 CTAACTCTTTGGATCTCCCTTTAAAGTGACCCTAATCTGGCTGCATTGATGGCCAGATTGTCTGCTGCCTTTGCACATCT
  81 AGTGCTGGTTTCAGAAATTTAATGAAACTTTTCTTTTTCCTTCGACCTCCTGAATCATGTGGTTCTGCAAATGAATACCT
 161 TCAACTAGGATTTAGACCACTAAGAACTTGCACAGAAAAACACGCATTGAATGTGTGTCGAACCTCTACATTGTGAAGTT
 241 GCACTATGTACCATACTCTAAAATGAAATAAGAACTCTTTATGTCTGTGAGAGAGTGTGTGTGTGTGTGTGCGTGCGTGT
 321 GTGCTTGTGGGGGTTGGGTAGTGTGTGTGTATTTTCTCTGGCTTTAAAATTTTAAAACAAACAAACAAAAAAGCCATAGA
 401 GAGCAGAACTTGCCGAGGGTCATTTATTGCCCAAGTTTACAAGAGTAGCGATACAAGTTTTTGCAAATTGAATTTGCCTC
 481 AGATATATCTGTCCTAATGCTTATATTTGCACAAGTATGTAAAATATCGTGTTGAGGATCATTCTTTGTTGGAAATACTG
 561 CTCTTGCTGAACTGTCTTGACCATTGACTATGACACAGTTTCTTATTTATGTAAATACTTGCATCACAGTGGCCGACAGG
 641 CATTGGATGCAGAACCTAGAGCCAGTTTTCAGGAACAATTGTAAACCTGACATGGTACTGTGCATCTATTCATAAAACAC
 721 TCAAAACTGTGAAAATATGGTTTACATTTAATTGTACATAAAGGTAAAGGGAGAACTCAATTCAGTACCAGTTAGTTTGT
 801 ACATTTTAGGGGGCTTTTCACATTAACTGCCCATTTGTGTAATTTATAGTTTGACATGATGTGTTTGTTTTAAAAAAAAA
 881 TGCATAGTATAAACCCATTAAGGATCTGGGAAAAGAGAAGAAGTTTAATATAGAACTAAGCTTTTAAAGTTTGTTTTTGT
 961 TTTTAATTCTGGTCTCGGTGCAAATGTTAGTTATGCCTTATTCATATCACAGTTAGATCACCATGCTGCAACATGGTTTA
1041 TATTCATGCTGCCCTAGAAACTTTTGTAATTATTTGTTGCAAATTTGTGACTGTCCTTATTAACTTTCTTTTATGTAAGT
1121 AATTTGTAAAAGTTTCTTAAAATTTTTGCTTTTGCTTATTTAATTTTGAATAAAAGCTAAATTCCTAATACTTTTTCTTA
1201 AAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uacAGGGUGGGGGU-GAGGACa 5'
             |::: |::| | |||||| 
Target 5' tctTTTTCCTTCGACCTCCTGa 3'
112 - 133 122.00 -16.00
2
miRNA  3' uacAGGGUGGGG---GUGAGGACa 5'
             | |::|||:    |||::|| 
Target 5' tcaTGCTGCCCTAGAAACTTTTGt 3'
1044 - 1067 118.00 -15.20
3
miRNA  3' uacagggugggGGUGAGGACa 5'
                     |::|||:|| 
Target 5' tgttggaaataCTGCTCTTGc 3'
547 - 567 114.00 -9.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30529544 55 COSMIC
COSN8892577 60 COSMIC
COSN31539336 65 COSMIC
COSN31499322 90 COSMIC
COSN31583622 113 COSMIC
COSN31558550 123 COSMIC
COSN31570705 152 COSMIC
COSN28758168 170 COSMIC
COSN15361577 285 COSMIC
COSN31534274 294 COSMIC
COSN23192503 295 COSMIC
COSN31531483 645 COSMIC
COSN26602246 650 COSMIC
COSN21144998 652 COSMIC
COSN31608040 696 COSMIC
COSN31579088 741 COSMIC
COSN25946496 762 COSMIC
COSN31513358 871 COSMIC
COSN30172873 872 COSMIC
COSN28196103 922 COSMIC
COSN6911005 993 COSMIC
COSN31608043 1131 COSMIC
COSN31536703 1134 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs754497154 1 dbSNP
rs138890174 2 dbSNP
rs753356142 2 dbSNP
rs1247052956 4 dbSNP
rs774543452 5 dbSNP
rs373942325 7 dbSNP
rs1275883999 13 dbSNP
rs1218052967 15 dbSNP
rs762947153 17 dbSNP
rs1298867227 18 dbSNP
rs1231104259 19 dbSNP
rs202139816 26 dbSNP
rs1332170393 28 dbSNP
rs80200850 37 dbSNP
rs150255759 43 dbSNP
rs1218588101 45 dbSNP
rs376576528 46 dbSNP
rs372985198 48 dbSNP
rs371012705 51 dbSNP
rs1196548220 65 dbSNP
rs567310577 69 dbSNP
rs1440476017 72 dbSNP
rs1212021374 79 dbSNP
rs952826289 85 dbSNP
rs1477424702 87 dbSNP
rs1414130527 94 dbSNP
rs746883489 100 dbSNP
rs1477869107 102 dbSNP
rs1171626053 103 dbSNP
rs1399667686 105 dbSNP
rs1413101323 108 dbSNP
rs1336504937 113 dbSNP
rs1376478200 119 dbSNP
rs58497791 120 dbSNP
rs527605969 123 dbSNP
rs1409977039 124 dbSNP
rs1274450612 127 dbSNP
rs1343195201 130 dbSNP
rs1395140338 133 dbSNP
rs1280725929 134 dbSNP
rs1165853409 136 dbSNP
rs566638741 141 dbSNP
rs1019498624 145 dbSNP
rs994300296 147 dbSNP
rs1189042792 151 dbSNP
rs898664588 154 dbSNP
rs768341690 162 dbSNP
rs1447073077 164 dbSNP
rs1197607263 165 dbSNP
rs1375452600 174 dbSNP
rs777791897 178 dbSNP
rs999137693 184 dbSNP
rs1007137435 189 dbSNP
rs1419544722 191 dbSNP
rs1184081928 192 dbSNP
rs189230050 203 dbSNP
rs1021906750 204 dbSNP
rs1011391310 209 dbSNP
rs1272357386 212 dbSNP
rs1051179387 216 dbSNP
rs1194338666 219 dbSNP
rs894247899 220 dbSNP
rs1235606148 225 dbSNP
rs1273610714 228 dbSNP
rs1055524967 230 dbSNP
rs933770220 236 dbSNP
rs533183103 238 dbSNP
rs1232395781 242 dbSNP
rs773372228 243 dbSNP
rs906829624 246 dbSNP
rs902227364 248 dbSNP
rs1209199108 260 dbSNP
rs1042205340 271 dbSNP
rs1452850863 272 dbSNP
rs946591324 275 dbSNP
rs1334711348 278 dbSNP
rs1036027440 280 dbSNP
rs1442691188 281 dbSNP
rs1454721670 282 dbSNP
rs565233073 287 dbSNP
rs772353556 293 dbSNP
rs543939030 294 dbSNP
rs531561833 295 dbSNP
rs116604449 296 dbSNP
rs1376490432 296 dbSNP
rs771038651 296 dbSNP
rs1311133619 298 dbSNP
rs1470784186 298 dbSNP
rs921360271 299 dbSNP
rs971511701 301 dbSNP
rs1263675815 303 dbSNP
rs1232411051 305 dbSNP
rs1176808913 307 dbSNP
rs1213818159 308 dbSNP
rs975435396 310 dbSNP
rs1253793661 311 dbSNP
rs1253012940 312 dbSNP
rs1456134962 312 dbSNP
rs149483963 312 dbSNP
rs186016177 312 dbSNP
rs368922505 312 dbSNP
rs3839870 312 dbSNP
rs768169225 312 dbSNP
rs972807172 312 dbSNP
rs3802267 313 dbSNP
rs1373774587 314 dbSNP
rs1395311619 314 dbSNP
rs199526969 314 dbSNP
rs1310454744 316 dbSNP
rs1319768987 316 dbSNP
rs775331481 317 dbSNP
rs1276970525 320 dbSNP
rs1315534569 320 dbSNP
rs1251587411 325 dbSNP
rs954412396 325 dbSNP
rs1029339564 326 dbSNP
rs1200281401 327 dbSNP
rs998221211 331 dbSNP
rs967724980 332 dbSNP
rs547887254 333 dbSNP
rs1422939443 337 dbSNP
rs1021519567 345 dbSNP
rs778998003 347 dbSNP
rs1442392326 355 dbSNP
rs1371282771 357 dbSNP
rs1355380853 358 dbSNP
rs902174596 362 dbSNP
rs958495363 371 dbSNP
rs560445426 378 dbSNP
rs1438240295 382 dbSNP
rs1297518309 386 dbSNP
rs1348549583 386 dbSNP
rs1337755089 388 dbSNP
rs1010597525 390 dbSNP
rs1295808525 390 dbSNP
rs200233077 393 dbSNP
rs1407824839 398 dbSNP
rs1230648976 403 dbSNP
rs1034105724 404 dbSNP
rs545247913 408 dbSNP
rs1455690739 412 dbSNP
rs867503977 414 dbSNP
rs768674937 415 dbSNP
rs1487333231 417 dbSNP
rs1188412667 421 dbSNP
rs1054859675 422 dbSNP
rs190622882 429 dbSNP
rs1432777284 432 dbSNP
rs1174222735 434 dbSNP
rs1435162850 442 dbSNP
rs1036465298 443 dbSNP
rs1297500450 447 dbSNP
rs1358590008 448 dbSNP
rs1395755873 449 dbSNP
rs1288892349 450 dbSNP
rs1193296259 454 dbSNP
rs1487611461 457 dbSNP
rs1384658381 469 dbSNP
rs1243665692 470 dbSNP
rs769731306 472 dbSNP
rs1216182193 476 dbSNP
rs1004532734 480 dbSNP
rs937954239 484 dbSNP
rs1285904659 485 dbSNP
rs1283714183 487 dbSNP
rs757791406 490 dbSNP
rs527755695 494 dbSNP
rs1242704369 504 dbSNP
rs745857377 512 dbSNP
rs1488204183 514 dbSNP
rs1048609161 517 dbSNP
rs1255200296 518 dbSNP
rs1157878000 523 dbSNP
rs537954429 527 dbSNP
rs781079690 528 dbSNP
rs1046309773 529 dbSNP
rs1302031611 530 dbSNP
rs112107466 533 dbSNP
rs1363580669 535 dbSNP
rs1371345001 537 dbSNP
rs1039844513 540 dbSNP
rs562872629 548 dbSNP
rs918579036 553 dbSNP
rs7005881 556 dbSNP
rs1225913249 562 dbSNP
rs184478014 563 dbSNP
rs1321190328 565 dbSNP
rs551702763 566 dbSNP
rs1296953492 576 dbSNP
rs1211944939 579 dbSNP
rs1275257755 583 dbSNP
rs777370829 590 dbSNP
rs1437103237 593 dbSNP
rs967376289 598 dbSNP
rs1173044453 602 dbSNP
rs1178291929 605 dbSNP
rs758070127 605 dbSNP
rs1471072731 606 dbSNP
rs1177708791 613 dbSNP
rs1413033719 622 dbSNP
rs1403078147 626 dbSNP
rs985593043 630 dbSNP
rs752355927 634 dbSNP
rs1421846129 635 dbSNP
rs764859211 636 dbSNP
rs1353102828 639 dbSNP
rs1474998392 640 dbSNP
rs1260745966 643 dbSNP
rs1212994164 645 dbSNP
rs1485939055 649 dbSNP
rs958611129 658 dbSNP
rs1295160551 661 dbSNP
rs1207353025 666 dbSNP
rs1308902843 670 dbSNP
rs1295937601 676 dbSNP
rs752261874 678 dbSNP
rs1271230739 679 dbSNP
rs1439310081 686 dbSNP
rs1034220267 688 dbSNP
rs1236707633 691 dbSNP
rs1471749007 692 dbSNP
rs539249750 693 dbSNP
rs569046004 694 dbSNP
rs1477240767 695 dbSNP
rs1340355539 702 dbSNP
rs1168085419 703 dbSNP
rs549958390 708 dbSNP
rs141868070 709 dbSNP
rs1276666757 712 dbSNP
rs1329904406 722 dbSNP
rs1417198432 731 dbSNP
rs560910718 737 dbSNP
rs548948378 739 dbSNP
rs1315432032 755 dbSNP
rs574220076 757 dbSNP
rs1218137327 758 dbSNP
rs1268617999 761 dbSNP
rs192134395 762 dbSNP
rs893527145 769 dbSNP
rs188759613 770 dbSNP
rs1356351294 771 dbSNP
rs887415718 772 dbSNP
rs1002405298 773 dbSNP
rs1027652904 784 dbSNP
rs995753388 785 dbSNP
rs879723141 788 dbSNP
rs1190458408 790 dbSNP
rs1243366439 794 dbSNP
rs1475514472 798 dbSNP
rs867337637 803 dbSNP
rs1046776192 808 dbSNP
rs1039873685 812 dbSNP
rs1433323319 813 dbSNP
rs944187694 830 dbSNP
rs766904860 831 dbSNP
rs897179190 833 dbSNP
rs1475505261 839 dbSNP
rs1256642060 844 dbSNP
rs1037006186 847 dbSNP
rs1481364223 854 dbSNP
rs1041771598 855 dbSNP
rs941434265 857 dbSNP
rs1345460839 867 dbSNP
rs946043615 871 dbSNP
rs914620544 872 dbSNP
rs368557756 881 dbSNP
rs565391705 881 dbSNP
rs932847179 882 dbSNP
rs990143926 884 dbSNP
rs1447092457 887 dbSNP
rs1197720484 896 dbSNP
rs977431427 906 dbSNP
rs966962312 909 dbSNP
rs1195837720 911 dbSNP
rs1235463537 914 dbSNP
rs1336116206 917 dbSNP
rs1312715971 920 dbSNP
rs1394784536 928 dbSNP
rs1387223478 929 dbSNP
rs1323102539 930 dbSNP
rs1375681128 937 dbSNP
rs1443405972 941 dbSNP
rs937271851 948 dbSNP
rs866987671 962 dbSNP
rs13328386 963 dbSNP
rs957784601 965 dbSNP
rs1033426021 971 dbSNP
rs578080642 973 dbSNP
rs1461830610 976 dbSNP
rs761002158 977 dbSNP
rs1213936965 978 dbSNP
rs773631881 983 dbSNP
rs1253963561 993 dbSNP
rs1418923605 1004 dbSNP
rs1015093494 1010 dbSNP
rs1366095113 1015 dbSNP
rs1420776770 1017 dbSNP
rs983182093 1022 dbSNP
rs1392410989 1036 dbSNP
rs1463148124 1040 dbSNP
rs1326843271 1042 dbSNP
rs11542169 1045 dbSNP
rs993836474 1048 dbSNP
rs1389501357 1051 dbSNP
rs1309030696 1053 dbSNP
rs1336230499 1055 dbSNP
rs897713221 1057 dbSNP
rs951884508 1060 dbSNP
rs1027308853 1064 dbSNP
rs1244016294 1065 dbSNP
rs767733299 1070 dbSNP
rs563120225 1071 dbSNP
rs1176078858 1076 dbSNP
rs1290835434 1078 dbSNP
rs1456181057 1079 dbSNP
rs1213920772 1082 dbSNP
rs74584736 1083 dbSNP
rs573765062 1091 dbSNP
rs1480490921 1095 dbSNP
rs1194485887 1097 dbSNP
rs1018452675 1100 dbSNP
rs1213925656 1101 dbSNP
rs941381793 1108 dbSNP
rs888441192 1117 dbSNP
rs1018856 1123 dbSNP
rs1008360341 1128 dbSNP
rs1415696455 1132 dbSNP
rs1050298702 1139 dbSNP
rs932732729 1140 dbSNP
rs1372769512 1148 dbSNP
rs1265200953 1150 dbSNP
rs1396949105 1152 dbSNP
rs1243301546 1154 dbSNP
rs922779258 1156 dbSNP
rs1018855 1157 dbSNP
rs976916197 1163 dbSNP
rs1480837596 1164 dbSNP
rs891256136 1167 dbSNP
rs945638012 1170 dbSNP
rs1319207992 1174 dbSNP
rs118028869 1187 dbSNP
rs533768262 1191 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' uacAGGGUGGGGGU-GAGGACa 5'
             |::: |::| | |||||| 
Target 5' ucuUUUUCCUUCGACCUCCUG- 3'
8 - 28
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000398246.3 | 3UTR | AAACUUUUCUUUUUCCUUCGACCUCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
256 hsa-miR-4433a-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT088097 SEPT2 septin 2 2 2
MIRT143134 MGRN1 mahogunin ring finger 1 2 2
MIRT153912 NCOA3 nuclear receptor coactivator 3 2 2
MIRT154894 GNAS GNAS complex locus 2 4
MIRT200996 ZNF805 zinc finger protein 805 2 2
MIRT215729 C5ORF51 chromosome 5 open reading frame 51 2 10
MIRT235593 POFUT1 protein O-fucosyltransferase 1 2 2
MIRT263250 SGPL1 sphingosine-1-phosphate lyase 1 2 2
MIRT317951 CDC5L cell division cycle 5 like 2 4
MIRT325572 HIATL1 major facilitator superfamily domain containing 14B 2 4
MIRT354739 LSM3 LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated 2 2
MIRT444552 UBE2D3 ubiquitin conjugating enzyme E2 D3 2 4
MIRT446978 SUSD5 sushi domain containing 5 2 2
MIRT451036 ZNF610 zinc finger protein 610 2 2
MIRT451596 TRPM7 transient receptor potential cation channel subfamily M member 7 2 2
MIRT452025 NLRP6 NLR family pyrin domain containing 6 2 2
MIRT452594 CA6 carbonic anhydrase 6 2 2
MIRT452768 TCEA3 transcription elongation factor A3 2 4
MIRT452959 ZNF844 zinc finger protein 844 2 2
MIRT453191 ACSF2 acyl-CoA synthetase family member 2 2 2
MIRT453382 RHD Rh blood group D antigen 2 2
MIRT453685 CEBPD CCAAT/enhancer binding protein delta 2 2
MIRT455272 DDX39B DExD-box helicase 39B 2 8
MIRT455346 BAMBI BMP and activin membrane bound inhibitor 2 2
MIRT456494 SERAC1 serine active site containing 1 2 2
MIRT456585 NID1 nidogen 1 2 2
MIRT456888 DDA1 DET1 and DDB1 associated 1 2 2
MIRT457123 APOLD1 apolipoprotein L domain containing 1 2 2
MIRT457852 ZNF324B zinc finger protein 324B 2 2
MIRT457987 APAF1 apoptotic peptidase activating factor 1 2 2
MIRT459278 APOBEC3F apolipoprotein B mRNA editing enzyme catalytic subunit 3F 2 2
MIRT459625 SLC25A33 solute carrier family 25 member 33 2 2
MIRT459715 SGK494 uncharacterized serine/threonine-protein kinase SgK494 2 2
MIRT460057 RPL22L1 ribosomal protein L22 like 1 2 2
MIRT460182 UNK unkempt family zinc finger 2 6
MIRT460288 PDE11A phosphodiesterase 11A 2 2
MIRT460841 EGF epidermal growth factor 2 4
MIRT460860 TBC1D19 TBC1 domain family member 19 2 2
MIRT461519 EMC7 ER membrane protein complex subunit 7 2 2
MIRT461729 SLC27A1 solute carrier family 27 member 1 2 4
MIRT461821 SNAP23 synaptosome associated protein 23 2 2
MIRT462066 CCDC77 coiled-coil domain containing 77 2 4
MIRT462084 MSANTD2 Myb/SANT DNA binding domain containing 2 2 2
MIRT462508 MTFMT mitochondrial methionyl-tRNA formyltransferase 2 10
MIRT464239 VCP valosin containing protein 2 2
MIRT465316 TRAF5 TNF receptor associated factor 5 2 2
MIRT466549 TBL1XR1 transducin beta like 1 X-linked receptor 1 2 2
MIRT467128 SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 2 8
MIRT468091 SHCBP1 SHC binding and spindle associated 1 2 2
MIRT469630 RAD21 RAD21 cohesin complex component 2 6
MIRT471097 PIK3C2B phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta 2 2
MIRT472704 MYBL1 MYB proto-oncogene like 1 2 2
MIRT472830 MTMR10 myotubularin related protein 10 2 2
MIRT472872 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 2
MIRT472895 MTDH metadherin 2 2
MIRT473728 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT473859 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT474047 LONRF1 LON peptidase N-terminal domain and ring finger 1 2 2
MIRT474297 LAMC1 laminin subunit gamma 1 2 2
MIRT474658 KLF13 Kruppel like factor 13 2 2
MIRT475234 IKZF3 IKAROS family zinc finger 3 2 2
MIRT475500 HSP90B1 heat shock protein 90 beta family member 1 2 2
MIRT475742 HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 2 4
MIRT475793 HDGF heparin binding growth factor 2 2
MIRT477254 ERGIC2 ERGIC and golgi 2 2 2
MIRT478228 DDX52 DExD-box helicase 52 2 2
MIRT478393 DCTN5 dynactin subunit 5 2 2
MIRT478754 CS citrate synthase 2 2
MIRT478827 CRKL CRK like proto-oncogene, adaptor protein 2 4
MIRT480234 C9orf41 carnosine N-methyltransferase 1 2 2
MIRT480597 BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 2 2
MIRT484121 C14orf142 GON7, KEOPS complex subunit homolog 2 2
MIRT484689 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT486331 C11orf54 chromosome 11 open reading frame 54 2 4
MIRT488599 FAM3C family with sequence similarity 3 member C 2 8
MIRT488833 MRRF mitochondrial ribosome recycling factor 2 2
MIRT492523 RAB15 RAB15, member RAS oncogene family 2 4
MIRT493632 HIC2 HIC ZBTB transcriptional repressor 2 2 2
MIRT500026 ABCF2 ATP binding cassette subfamily F member 2 2 8
MIRT501075 SMAD7 SMAD family member 7 2 8
MIRT503094 BTG2 BTG anti-proliferation factor 2 2 4
MIRT503336 MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2 2
MIRT505465 STMN1 stathmin 1 2 4
MIRT505726 SERTAD3 SERTA domain containing 3 2 4
MIRT509333 MS4A4A membrane spanning 4-domains A4A 2 2
MIRT509978 KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 2 4
MIRT513068 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT513446 EMP1 epithelial membrane protein 1 2 6
MIRT513736 PSD3 pleckstrin and Sec7 domain containing 3 2 4
MIRT513996 CENPQ centromere protein Q 2 4
MIRT516538 MIXL1 Mix paired-like homeobox 2 2
MIRT517606 SAV1 salvador family WW domain containing protein 1 2 2
MIRT518064 CEP89 centrosomal protein 89 2 2
MIRT518119 RNMTL1 mitochondrial rRNA methyltransferase 3 2 2
MIRT518325 WDR92 WD repeat domain 92 2 2
MIRT519048 ABCB11 ATP binding cassette subfamily B member 11 2 2
MIRT520972 SPPL2A signal peptide peptidase like 2A 2 4
MIRT521359 RPL35A ribosomal protein L35a 2 2
MIRT523359 GTF3C6 general transcription factor IIIC subunit 6 2 2
MIRT523801 FAM63A MINDY lysine 48 deubiquitinase 1 2 2
MIRT524622 C7orf73 short transmembrane mitochondrial protein 1 2 2
MIRT525550 PHB2 prohibitin 2 2 4
MIRT529709 ZBTB49 zinc finger and BTB domain containing 49 2 2
MIRT531605 PLEKHA6 pleckstrin homology domain containing A6 2 2
MIRT532387 UMPS uridine monophosphate synthetase 2 2
MIRT534468 SCD stearoyl-CoA desaturase 2 4
MIRT537546 ETNK1 ethanolamine kinase 1 2 2
MIRT541619 C11orf31 selenoprotein H 2 2
MIRT548380 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 4
MIRT549523 HDDC2 HD domain containing 2 2 2
MIRT549774 SOD2 superoxide dismutase 2 2 2
MIRT550578 SLC2A5 solute carrier family 2 member 5 2 2
MIRT551498 CENPN centromere protein N 2 4
MIRT552301 ITGA3 integrin subunit alpha 3 2 2
MIRT555400 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT556399 LUC7L LUC7 like 2 2
MIRT557047 HOXB3 homeobox B3 2 2
MIRT558072 ERO1L endoplasmic reticulum oxidoreductase 1 alpha 1 2
MIRT559659 AHCYL2 adenosylhomocysteinase like 2 2 2
MIRT561239 ZNF354B zinc finger protein 354B 2 2
MIRT566899 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 2
MIRT568786 FAM120B family with sequence similarity 120B 2 2
MIRT574014 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT574885 Dnajc6 DnaJ heat shock protein family (Hsp40) member C6 2 2
MIRT575243 Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 2 2
MIRT576194 Vsig2 V-set and immunoglobulin domain containing 2 2 2
MIRT576309 Acbd7 acyl-Coenzyme A binding domain containing 7 2 2
MIRT576484 Lhx4 LIM homeobox protein 4 2 3
MIRT576646 Mill2 MHC I like leukocyte 2 1 1
MIRT576708 Kras Kirsten rat sarcoma viral oncogene homolog 2 2
MIRT576855 Socs6 suppressor of cytokine signaling 6 2 2
MIRT576950 Aldoa aldolase A, fructose-bisphosphate 2 2
MIRT617133 ZNF556 zinc finger protein 556 2 4
MIRT617928 ZNF783 zinc finger family member 783 2 2
MIRT618981 MRPS16 mitochondrial ribosomal protein S16 2 2
MIRT621100 SIX3 SIX homeobox 3 2 2
MIRT624537 BROX BRO1 domain and CAAX motif containing 2 2
MIRT625663 C2orf48 chromosome 2 open reading frame 48 2 2
MIRT627059 DCTN6 dynactin subunit 6 2 2
MIRT628319 CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 2 2
MIRT630859 ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 2 2
MIRT632295 TMEM65 transmembrane protein 65 2 2
MIRT634115 ZNF207 zinc finger protein 207 2 2
MIRT634736 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT635655 NDST3 N-deacetylase and N-sulfotransferase 3 2 2
MIRT635772 PDCL3 phosducin like 3 2 2
MIRT635911 LILRA2 leukocyte immunoglobulin like receptor A2 2 2
MIRT636365 OGFRL1 opioid growth factor receptor like 1 2 4
MIRT637251 GLRX2 glutaredoxin 2 2 2
MIRT638705 FZD4 frizzled class receptor 4 2 2
MIRT639640 PREX2 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 2 2
MIRT639676 PPEF2 protein phosphatase with EF-hand domain 2 2 4
MIRT642267 SMIM17 small integral membrane protein 17 2 2
MIRT642372 ZNF581 zinc finger protein 581 2 2
MIRT643545 SLC25A17 solute carrier family 25 member 17 2 2
MIRT647994 PDE12 phosphodiesterase 12 2 2
MIRT649094 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT650993 ZNF770 zinc finger protein 770 2 2
MIRT651956 UBE2N ubiquitin conjugating enzyme E2 N 2 2
MIRT652977 SUN2 Sad1 and UNC84 domain containing 2 2 2
MIRT654389 RBM12B RNA binding motif protein 12B 2 2
MIRT655637 OLFML2A olfactomedin like 2A 2 2
MIRT655729 NRXN3 neurexin 3 2 2
MIRT658171 FCHSD1 FCH and double SH3 domains 1 2 2
MIRT660937 ACOX1 acyl-CoA oxidase 1 2 2
MIRT662112 CERKL ceramide kinase like 2 2
MIRT662302 MPV17L MPV17 mitochondrial inner membrane protein like 2 2
MIRT662993 TMEM59 transmembrane protein 59 2 2
MIRT663071 SFR1 SWI5 dependent homologous recombination repair protein 1 2 2
MIRT663704 ABHD17B abhydrolase domain containing 17B 2 2
MIRT663864 MUC20 mucin 20, cell surface associated 2 2
MIRT665185 HAUS5 HAUS augmin like complex subunit 5 2 4
MIRT665402 WEE1 WEE1 G2 checkpoint kinase 2 2
MIRT665688 TNPO3 transportin 3 2 2
MIRT665795 TMEM170A transmembrane protein 170A 2 2
MIRT665847 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT666999 PDPN podoplanin 2 2
MIRT667598 LIPC lipase C, hepatic type 2 2
MIRT668576 ELMSAN1 ELM2 and Myb/SANT domain containing 1 2 4
MIRT670960 UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2 2
MIRT671187 ZNF891 zinc finger protein 891 2 2
MIRT671739 ZNF451 zinc finger protein 451 2 2
MIRT672745 ZNF585B zinc finger protein 585B 2 4
MIRT673446 ZNF583 zinc finger protein 583 2 2
MIRT679843 GPR75 G protein-coupled receptor 75 2 2
MIRT680556 ZNF584 zinc finger protein 584 2 2
MIRT680661 C1orf210 chromosome 1 open reading frame 210 2 2
MIRT681285 RFC2 replication factor C subunit 2 2 2
MIRT683264 ZNF329 zinc finger protein 329 2 2
MIRT684519 C1orf174 chromosome 1 open reading frame 174 2 2
MIRT685065 GEMIN4 gem nuclear organelle associated protein 4 2 2
MIRT685157 DTWD2 DTW domain containing 2 2 2
MIRT685168 ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit 2 2
MIRT685470 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT686001 NEK4 NIMA related kinase 4 2 2
MIRT687027 RNF24 ring finger protein 24 2 2
MIRT687543 MOB1B MOB kinase activator 1B 2 2
MIRT687592 MANEAL mannosidase endo-alpha like 2 2
MIRT687753 KIAA1328 KIAA1328 2 2
MIRT688050 GLUL glutamate-ammonia ligase 2 2
MIRT688374 ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 2 2
MIRT688802 CBFA2T3 CBFA2/RUNX1 translocation partner 3 2 2
MIRT688957 ATXN3 ataxin 3 2 2
MIRT689281 C5AR2 complement component 5a receptor 2 2 2
MIRT689988 NNMT nicotinamide N-methyltransferase 2 2
MIRT689997 MMP17 matrix metallopeptidase 17 2 2
MIRT690014 LUZP2 leucine zipper protein 2 2 2
MIRT690161 ELP3 elongator acetyltransferase complex subunit 3 2 2
MIRT690379 ZSWIM7 zinc finger SWIM-type containing 7 2 2
MIRT690563 MICA MHC class I polypeptide-related sequence A 2 2
MIRT691891 EVC EvC ciliary complex subunit 1 2 2
MIRT693107 SCNM1 sodium channel modifier 1 2 2
MIRT693832 ZFP64 ZFP64 zinc finger protein 2 2
MIRT694105 ZNF446 zinc finger protein 446 2 2
MIRT694179 ZNF486 zinc finger protein 486 2 2
MIRT694475 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT694998 GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 2 2
MIRT695031 ALG10B ALG10B, alpha-1,2-glucosyltransferase 2 2
MIRT695163 TCTN2 tectonic family member 2 2 2
MIRT695525 SLC25A34 solute carrier family 25 member 34 2 2
MIRT696067 ZNF264 zinc finger protein 264 2 2
MIRT696616 CRIPT CXXC repeat containing interactor of PDZ3 domain 2 2
MIRT696661 AGXT2 alanine--glyoxylate aminotransferase 2 2 2
MIRT696705 PNPO pyridoxamine 5'-phosphate oxidase 2 2
MIRT697173 INMT indolethylamine N-methyltransferase 2 2
MIRT697303 ZNF652 zinc finger protein 652 2 2
MIRT697491 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT698657 TERF2 telomeric repeat binding factor 2 2 2
MIRT699042 SOAT1 sterol O-acyltransferase 1 2 2
MIRT699185 SLX4IP SLX4 interacting protein 2 2
MIRT699598 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT700150 RNF115 ring finger protein 115 2 2
MIRT700720 PNO1 partner of NOB1 homolog 2 2
MIRT700870 PER2 period circadian clock 2 2 2
MIRT700912 PDXK pyridoxal kinase 2 2
MIRT701095 PAPOLG poly(A) polymerase gamma 2 2
MIRT701194 OTUD3 OTU deubiquitinase 3 2 2
MIRT702203 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT702272 LHX4 LIM homeobox 4 2 3
MIRT703125 GPRC5A G protein-coupled receptor class C group 5 member A 2 2
MIRT703252 GNS glucosamine (N-acetyl)-6-sulfatase 2 2
MIRT703262 GNL3L G protein nucleolar 3 like 2 2
MIRT703440 FYTTD1 forty-two-three domain containing 1 2 2
MIRT704321 DCUN1D5 defective in cullin neddylation 1 domain containing 5 2 2
MIRT704393 CTSS cathepsin S 2 2
MIRT704483 CPT1A carnitine palmitoyltransferase 1A 2 2
MIRT704880 CCSER2 coiled-coil serine rich protein 2 2 2
MIRT704926 CCDC36 coiled-coil domain containing 36 2 2
MIRT705175 BZW1 basic leucine zipper and W2 domains 1 2 2
MIRT706561 EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 2 2
MIRT707048 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT711497 PGD phosphogluconate dehydrogenase 2 2
MIRT716644 EPGN epithelial mitogen 2 2
MIRT720083 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT722288 PMPCA peptidase, mitochondrial processing alpha subunit 2 2
MIRT725468 GRAP2 GRB2-related adaptor protein 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4433a Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4433a Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-mir-4433a Vincristine 5978 approved resistant cell line (W1)
hsa-mir-4433a Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4433a-3p Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4433a-3p Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-4433a-3p Cisplatin 5460033 NSC119875 approved resistant High Pancreatic Cancer cell line (BxPC-3)
hsa-miR-4433a-3p Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4433a-3p Imatinib 5291 NSC743414 approved sensitive High Chronic Myelogenous Leukemia tissue
hsa-miR-4433a-3p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780CIS)
hsa-miR-4433a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (mitochondrial RNA)
hsa-miR-4433a-3p Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-miR-4433a-3p Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-miR-4433a-3p Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-4433a-3p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-4433a-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4433a-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)

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