miRTarBase - #MIRT474307


—
pre-miRNA Information
pre-miRNA hsa-mir-4745   
Genomic Coordinates chr19: 804940 - 805001
Description Homo sapiens miR-4745 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4745-5p
Sequence 2| UGAGUGGGGCUCCCGGGACGGCG |24
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM6231418 6 COSMIC
COSN9853232 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1383282684 5 dbSNP
rs1397680926 5 dbSNP
rs569478349 7 dbSNP
rs1370492118 8 dbSNP
rs773676198 9 dbSNP
rs1163342742 10 dbSNP
rs1364058972 13 dbSNP
rs374562787 14 dbSNP
rs771228280 15 dbSNP
rs10422347 19 dbSNP
rs759808148 20 dbSNP
rs765171167 21 dbSNP
rs147466582 22 dbSNP
rs139864698 23 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol LAMC1   
Synonyms LAMB2
Description laminin subunit gamma 1
Transcript NM_002293   
Expression
Putative miRNA Targets on LAMC1
3'UTR of LAMC1
(miRNA target sites are highlighted)		 
>LAMC1|NM_002293|3'UTR
   1 TGTCTTTAGGGCTGGAAGGCAGCATCCCTCTGACAGGGGGGCAGTTGTGAGGCCACAGAGTGCCTTGACACAAAGATTAC
  81 ATTTTTCAGACCCCCACTCCTCTGCTGCTGTCCATGACTGTCCTTTTGAACCAGGAAAAGTCACAGAGTTTAAAGAGAAG
 161 CAAATTAAACATCCTGAATCGGGAACAAAGGGTTTTATCTAATAAAGTGTCTCTTCCATTCACGTTGCTACCTTACCCAC
 241 ACTTTCCCTTCTGATTTGCGTGAGGACGTGGCATCCTACGTTACTGTACAGTGGCATAAGCACATCGTGTGAGCCCATGT
 321 ATGCTGGGGTAGAGCAAGTAGCCCTCCCCTGTCTCATCGATACCAGCAGAACCTCCTCAGTCTCAGTACTCTTGTTTCTA
 401 TGAAGGAAAAGTTTGGCTACTAACAGTAGCATTGTGATGGCCAGTATATCCAGTCCATGGATAAAGAAAATGCATCTGCA
 481 TCTCCTACCCCTCTTCCTTCTAAGCAAAAGGAAATAAACATCCTGTGCCAAAGGTATTGGTCATTTAGAATGTCGGTAGC
 561 CATCCATCAGTGCTTTTAGTTATTATGAGTGTAGGACACTGAGCCATCCGTGGGTCAGGATGCAATTATTTATAAAAGTC
 641 TCCAGGTGAACATGGCTGAAGATTTTTCTAGTATATTAATAATTGACTAGGAAGATGAACTTTTTTTCAGATCTTTGGGC
 721 AGCTGATAATTTAAATCTGGATGGGCAGCTTGCACTCACCAATAGACCAAAAGACATCTTTTGATATTCTTATAAATGGA
 801 ACTTACACAGAAGAAATAGGGATATGATAACCACTAAAATTTTGTTTTCAAAATCAAACTAATTCTTACAGCTTTTTTAT
 881 TAGTTAGTCTTGGAACTAGTGTTAAGTATCTGGCAGAGAACAGTTAATCCCTAAGGTCTTGACAAAACAGAAGAAAAACA
 961 AGCCTCCTCGTCCTAGTCTTTTCTAGCAAAGGGATAAAACTTAGATGGCAGCTTGTACTGTCAGAATCCCGTGTATCCAT
1041 TTGTTCTTCTGTTGGAGAGATGAGACATTTGACCCTTAGCTCCAGTTTTCTTCTGATGTTTCCATCTTCCAGAATCCCTC
1121 AAAAAACATTGTTTGCCAAATCCTGGTGGCAAATACTTGCACTCAGTATTTCACACAGCTGCCAACGCTATCGAGTTCCT
1201 GCACTTTGTGATTTAAATCCACTCTAAACCTTCCCTCTAAGTGTAGAGGGAAGACCCTTACGTGGAGTTTCCTAGTGGGC
1281 TTCTCAACTTTTGATCCTCAGCTCTGTGGTTTTAAGACCACAGTGTGACAGTTCCCTGCCACACACCCCCTTCCTCCTAC
1361 CAACCCACCTTTGAGATTCATATATAGCCTTTAACACTATGCAACTTTGTACTTTGCGTAGCAGGGGCGGGGTGGGGGGA
1441 AAGAAACTATTATCTGACACACTGGTGCTATTAATTATTTCAAATTTATATTTTTGTGTGAATGTTTTGTGTTTTGTTTA
1521 TCATGATTATAGAATAAGGAATTTATGTAAATATACTTAGTCCTATTTCTAGAATGACACTCTGTTCACTTTGCTCAATT
1601 TTTCCTCTTCACTGGCACAATGTATCTGAATACCTCCTTCCCTCCCTTCTAGAATTCTTTGGATTGTACTCCAAAGAATT
1681 GTGCCTTGTGTTTGCAGCATCTCCATTCTCTAAAATTAATATAATTGCTTTCCTCCACACCCAGCCACTGTAAAGAGGTA
1761 ACTTGGGTCCTCTTCCATTGCAGTCCTGATGATCCTAACCTGCAGCACGGTGGTTTTACAATGTTCCAGAGCAGGAACGC
1841 CAGGTTGACAAGCTATGGTAGGATTAGGAAAGTTTGCTGAAGAGGATCTTTGACGCCACAGTGGGACTAGCCAGGAATGA
1921 GGGAGAAATGCCCTTTCTGGCAATTGTTGGAGCTGGATAGGTAAGTTTTATAAGGGAGTACATTTTGACTGAGCACTTAG
2001 GGCATCAGGAACAGTGCTACTTACTGATGGGTAGACTGGGAGAGGTGGTGTAACTTAGTTCTTGATGATCCCACTTCCTG
2081 TTTCCATCTGCTTGGGATATACCAGAGTTTACCACAAGTGTTTTGACGATATACTCCTGAGCTTTCACTCTGCTGCTTCT
2161 CCCAGGCCTCTTCTACTATGGCAGGAGATGTGGCGTGCTGTTGCAAAGTTTTCACGTCATTGTTTCCTGGCTAGTTCATT
2241 TCATTAAGTGGCTACATCCTAACATATGCATTTGGTCAAGGTTGCAGAAGAGGACTGAAGATTGACTGCCAAGCTAGTTT
2321 GGGTGAAGTTCACTCCAGCAAGTCTCAGGCCACAATGGGGTGGTTTGGTTTGGTTTCCTTTTAACTTTCTTTTTGTTATT
2401 TGCTTTTCTCCTCCACCTGTGTGGTATATTTTTTAAGCAGAATTTTATTTTTTAAAATAAAAGGTTCTTTACAAGATGAT
2481 ACCTTAATTACACTCCCGCAACACAGCCATTATTTTATTGTCTAGCTCCAGTTATCTGTATTTTATGTAATGTAATTGAC
2561 AGGATGGCTGCTGCAGAATGCTGGTTGACACAGGGATTATTATACTGCTATTTTTCCCTGAATTTTTTTCCTTTGAATTC
2641 CAACTGTGGACCTTTTATATGTGCCTTCACTTTAGCTGTTTGCCTTAATCTCTACAGCCTTGCTCTCCGGGGTGGTTAAT
2721 AAAATGCAACACTTGGCATTTTTATGTTTTAAGAAAAACAGTATTTTATTTATAATAAAATCTGAATATTTGTAACCCTT
2801 TA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gcggcAGGGCCCUCGGGGUGAGu 5'
               |:::  || |||||||| 
Target 5' tacatTTTTCAGACCCCCACTCc 3'
 78 - 100 154.00 -16.70
2 
miRNA  3' gcggCAGGGCC--CUCGGGGUGAGu 5'
              ||:|: |  || :||||||: 
Target 5' cttaGTTCTTGATGA-TCCCACTTc 3'
 2054 - 2077 136.00 -15.70
3 
miRNA  3' gcggcAGGGCCCUCG-GGGUGAGu 5'
               |||:  |||| ::||||| 
Target 5' tatacTCCT--GAGCTTTCACTCt 3'
 2130 - 2151 126.00 -16.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31508301 10 COSMIC
COSN30489057 16 COSMIC
COSN30763966 42 COSMIC
COSN30186656 52 COSMIC
COSN24308611 88 COSMIC
COSN30485250 101 COSMIC
COSN19612217 117 COSMIC
COSN31956561 129 COSMIC
COSN26641027 228 COSMIC
COSN31604137 263 COSMIC
COSN26644946 269 COSMIC
COSN31542038 438 COSMIC
COSN30544577 445 COSMIC
COSN22048188 486 COSMIC
COSN26637027 535 COSMIC
COSN5359175 544 COSMIC
COSN6431689 642 COSMIC
COSN22392489 801 COSMIC
COSN28734101 950 COSMIC
COSN20576559 1096 COSMIC
COSN7188030 1147 COSMIC
COSN8409993 1149 COSMIC
COSN1416664 1190 COSMIC
COSN27270136 1225 COSMIC
COSN30163146 1262 COSMIC
COSN31490157 1301 COSMIC
COSN26584905 1381 COSMIC
COSN31552462 1402 COSMIC
COSN26637650 1430 COSMIC
COSN31532078 1440 COSMIC
COSN25861420 1522 COSMIC
COSN5734510 1552 COSMIC
COSN8409994 1583 COSMIC
COSN31536972 1678 COSMIC
COSN19110993 1768 COSMIC
COSN19413799 1822 COSMIC
COSN4710223 1957 COSMIC
COSN28454313 2093 COSMIC
COSN31607444 2468 COSMIC
COSN31534342 2498 COSMIC
COSN15812336 2550 COSMIC
COSN15810564 2560 COSMIC
COSN5199113 2603 COSMIC
COSN31606437 2629 COSMIC
COSN15703747 2803 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1164451896 2 dbSNP
rs201626655 5 dbSNP
rs1314237291 6 dbSNP
rs764669967 8 dbSNP
rs1253287386 12 dbSNP
rs1288296284 17 dbSNP
rs752190138 18 dbSNP
rs375955439 23 dbSNP
rs1312709202 29 dbSNP
rs991512721 30 dbSNP
rs369905308 31 dbSNP
rs1246343298 32 dbSNP
rs199548614 35 dbSNP
rs770882218 35 dbSNP
rs777660255 35 dbSNP
rs756004793 36 dbSNP
rs979252161 36 dbSNP
rs751407961 37 dbSNP
rs374480765 40 dbSNP
rs904056588 41 dbSNP
rs1214459303 42 dbSNP
rs757029518 44 dbSNP
rs377612865 45 dbSNP
rs746088066 48 dbSNP
rs1446455949 49 dbSNP
rs770039799 52 dbSNP
rs781594663 60 dbSNP
rs112250010 72 dbSNP
rs549021467 75 dbSNP
rs1013718650 77 dbSNP
rs1024649325 81 dbSNP
rs932970582 86 dbSNP
rs769736763 88 dbSNP
rs1377624522 91 dbSNP
rs1173308849 95 dbSNP
rs1264898133 98 dbSNP
rs1253184758 102 dbSNP
rs1177655469 109 dbSNP
rs3359 117 dbSNP
rs1239788180 124 dbSNP
rs1002157043 135 dbSNP
rs575394952 140 dbSNP
rs1196216564 146 dbSNP
rs888838705 159 dbSNP
rs1482882485 168 dbSNP
rs1199883413 174 dbSNP
rs941777954 175 dbSNP
rs1350186488 182 dbSNP
rs115744717 192 dbSNP
rs1239716122 193 dbSNP
rs897989489 200 dbSNP
rs1331289675 204 dbSNP
rs952678331 205 dbSNP
rs1402097658 208 dbSNP
rs1301626239 210 dbSNP
rs531620214 211 dbSNP
rs982655849 212 dbSNP
rs1462614719 214 dbSNP
rs1467091672 218 dbSNP
rs1299965758 219 dbSNP
rs1395161927 224 dbSNP
rs749302418 225 dbSNP
rs1437418206 231 dbSNP
rs1381851936 235 dbSNP
rs1404504241 242 dbSNP
rs1423077832 243 dbSNP
rs896091162 246 dbSNP
rs1347728807 247 dbSNP
rs962163021 260 dbSNP
rs73036978 261 dbSNP
rs1308584247 266 dbSNP
rs1023393936 268 dbSNP
rs773937500 271 dbSNP
rs1240150622 274 dbSNP
rs968790884 279 dbSNP
rs17536791 280 dbSNP
rs1358297058 281 dbSNP
rs1311116639 285 dbSNP
rs778353035 297 dbSNP
rs925555231 303 dbSNP
rs1297035839 304 dbSNP
rs1417363379 307 dbSNP
rs1031789112 314 dbSNP
rs1158807881 316 dbSNP
rs1270559762 321 dbSNP
rs773501245 325 dbSNP
rs1189432515 335 dbSNP
rs12082233 345 dbSNP
rs1185702938 349 dbSNP
rs1262440176 350 dbSNP
rs369736427 359 dbSNP
rs892588929 360 dbSNP
rs1013376414 362 dbSNP
rs1046171767 363 dbSNP
rs1286554781 376 dbSNP
rs564758355 390 dbSNP
rs775428748 395 dbSNP
rs1172642053 401 dbSNP
rs532118065 402 dbSNP
rs3903140 416 dbSNP
rs1264031812 426 dbSNP
rs373230089 427 dbSNP
rs1001852864 438 dbSNP
rs1356624253 444 dbSNP
rs772760883 447 dbSNP
rs1278173744 449 dbSNP
rs759920663 450 dbSNP
rs985776567 457 dbSNP
rs1327687212 471 dbSNP
rs1164493476 474 dbSNP
rs550445093 476 dbSNP
rs1404383313 477 dbSNP
rs1388217120 482 dbSNP
rs1367657199 486 dbSNP
rs1062044 488 dbSNP
rs535903293 491 dbSNP
rs1288649135 501 dbSNP
rs1168489361 509 dbSNP
rs775974444 510 dbSNP
rs941740571 511 dbSNP
rs1004504581 512 dbSNP
rs1363272417 524 dbSNP
rs548388709 526 dbSNP
rs1451244822 532 dbSNP
rs1312302879 538 dbSNP
rs189751253 543 dbSNP
rs1265582576 546 dbSNP
rs763511588 553 dbSNP
rs1381463102 554 dbSNP
rs1335942150 555 dbSNP
rs1257933985 556 dbSNP
rs965587568 557 dbSNP
rs976163390 560 dbSNP
rs1369083579 580 dbSNP
rs879186628 580 dbSNP
rs944971 581 dbSNP
rs751591142 584 dbSNP
rs559184894 587 dbSNP
rs929438655 589 dbSNP
rs1327530818 592 dbSNP
rs1351050868 598 dbSNP
rs1399285522 600 dbSNP
rs953437661 601 dbSNP
rs1411575976 603 dbSNP
rs537688791 610 dbSNP
rs986106167 611 dbSNP
rs1261036378 613 dbSNP
rs1376083335 614 dbSNP
rs1195767229 617 dbSNP
rs180766784 621 dbSNP
rs1469140916 623 dbSNP
rs757316837 624 dbSNP
rs1197219398 626 dbSNP
rs1440031953 628 dbSNP
rs944970 642 dbSNP
rs1218082957 648 dbSNP
rs988796326 654 dbSNP
rs1342304522 673 dbSNP
rs914108521 674 dbSNP
rs183701964 688 dbSNP
rs904513113 696 dbSNP
rs1046204713 700 dbSNP
rs542311286 701 dbSNP
rs1329035865 708 dbSNP
rs371902982 709 dbSNP
rs904962818 712 dbSNP
rs1355012564 718 dbSNP
rs1387385168 722 dbSNP
rs1413938078 723 dbSNP
rs937716787 727 dbSNP
rs1373715068 736 dbSNP
rs536208110 742 dbSNP
rs1454869224 753 dbSNP
rs1158847993 758 dbSNP
rs1032154396 763 dbSNP
rs1455646912 764 dbSNP
rs1471375788 775 dbSNP
rs1233928413 779 dbSNP
rs879833063 779 dbSNP
rs956142347 784 dbSNP
rs1211058718 785 dbSNP
rs888072489 785 dbSNP
rs1352484877 791 dbSNP
rs1306689533 793 dbSNP
rs1335381492 805 dbSNP
rs1373823808 807 dbSNP
rs561090796 808 dbSNP
rs1015910712 809 dbSNP
rs987900434 820 dbSNP
rs1435470866 821 dbSNP
rs564716305 821 dbSNP
rs1370745120 823 dbSNP
rs1157239674 825 dbSNP
rs189193910 825 dbSNP
rs997990438 827 dbSNP
rs1409196092 829 dbSNP
rs1222801192 832 dbSNP
rs1028082905 837 dbSNP
rs6424890 840 dbSNP
rs1188015127 841 dbSNP
rs749104717 850 dbSNP
rs1487687785 852 dbSNP
rs1318543872 853 dbSNP
rs1032382797 857 dbSNP
rs910499682 859 dbSNP
rs1288874904 873 dbSNP
rs1207730356 879 dbSNP
rs1262491767 880 dbSNP
rs958270831 880 dbSNP
rs1293857335 881 dbSNP
rs1415435807 882 dbSNP
rs1339947479 888 dbSNP
rs1287277164 891 dbSNP
rs754892490 896 dbSNP
rs1433142186 904 dbSNP
rs914122682 907 dbSNP
rs949593119 914 dbSNP
rs565177492 918 dbSNP
rs1204387485 921 dbSNP
rs1166322800 930 dbSNP
rs1244979966 942 dbSNP
rs1468814076 961 dbSNP
rs926745868 966 dbSNP
rs532058318 970 dbSNP
rs181905506 971 dbSNP
rs1174727303 976 dbSNP
rs771529364 999 dbSNP
rs1336714058 1002 dbSNP
rs1273659439 1003 dbSNP
rs1217946396 1006 dbSNP
rs529759463 1009 dbSNP
rs888155817 1012 dbSNP
rs1293524637 1013 dbSNP
rs186551648 1016 dbSNP
rs939662306 1018 dbSNP
rs1362898162 1031 dbSNP
rs377603378 1032 dbSNP
rs76725020 1037 dbSNP
rs1397149176 1038 dbSNP
rs1045029021 1041 dbSNP
rs1465551438 1044 dbSNP
rs1440793510 1052 dbSNP
rs1371891275 1060 dbSNP
rs1171874649 1072 dbSNP
rs762164192 1078 dbSNP
rs998023043 1083 dbSNP
rs1221529144 1089 dbSNP
rs1469599747 1092 dbSNP
rs530158179 1099 dbSNP
rs1282320845 1100 dbSNP
rs1028114109 1113 dbSNP
rs1197848221 1115 dbSNP
rs766814539 1116 dbSNP
rs772888560 1119 dbSNP
rs1000580557 1129 dbSNP
rs552639222 1132 dbSNP
rs1280860289 1135 dbSNP
rs1007632101 1136 dbSNP
rs571125608 1141 dbSNP
rs538113258 1144 dbSNP
rs1302870167 1161 dbSNP
rs1232389060 1162 dbSNP
rs1032828054 1173 dbSNP
rs1304586339 1175 dbSNP
rs1446572865 1181 dbSNP
rs958088895 1186 dbSNP
rs569740662 1187 dbSNP
rs78248780 1188 dbSNP
rs191843096 1193 dbSNP
rs891842411 1194 dbSNP
rs998223298 1199 dbSNP
rs537745637 1202 dbSNP
rs1020925997 1203 dbSNP
rs970978193 1208 dbSNP
rs1428972642 1220 dbSNP
rs61809089 1221 dbSNP
rs1177755908 1237 dbSNP
rs1296652821 1238 dbSNP
rs982323502 1244 dbSNP
rs1481068236 1251 dbSNP
rs10911261 1258 dbSNP
rs1252531744 1260 dbSNP
rs1007418189 1262 dbSNP
rs1408921541 1263 dbSNP
rs959522893 1273 dbSNP
rs1017917068 1275 dbSNP
rs963337656 1278 dbSNP
rs973442176 1280 dbSNP
rs140350502 1287 dbSNP
rs1402648122 1293 dbSNP
rs181888770 1293 dbSNP
rs775774280 1295 dbSNP
rs1392464464 1297 dbSNP
rs1355452629 1304 dbSNP
rs1310505705 1305 dbSNP
rs950404870 1310 dbSNP
rs1375629128 1317 dbSNP
rs939756078 1318 dbSNP
rs1345861533 1334 dbSNP
rs1157713465 1336 dbSNP
rs1037110924 1340 dbSNP
rs992572102 1342 dbSNP
rs1406504786 1343 dbSNP
rs1182330373 1347 dbSNP
rs1268407319 1351 dbSNP
rs1423170497 1351 dbSNP
rs922230868 1357 dbSNP
rs933948207 1364 dbSNP
rs1281219955 1378 dbSNP
rs1204784722 1380 dbSNP
rs917033166 1381 dbSNP
rs763312152 1386 dbSNP
rs573116002 1388 dbSNP
rs1334746441 1390 dbSNP
rs1214070387 1391 dbSNP
rs577327693 1393 dbSNP
rs1000418646 1397 dbSNP
rs1344611581 1401 dbSNP
rs1386770825 1403 dbSNP
rs1044588825 1405 dbSNP
rs926169534 1416 dbSNP
rs1268411510 1418 dbSNP
rs1490629493 1419 dbSNP
rs1201444801 1423 dbSNP
rs1054272822 1426 dbSNP
rs145419702 1429 dbSNP
rs1009613772 1430 dbSNP
rs1475334740 1432 dbSNP
rs1445461103 1433 dbSNP
rs1168003709 1434 dbSNP
rs913826950 1434 dbSNP
rs1021379923 1435 dbSNP
rs891789029 1436 dbSNP
rs1206043546 1448 dbSNP
rs1468346417 1450 dbSNP
rs764548186 1454 dbSNP
rs1235696314 1462 dbSNP
rs1336187033 1465 dbSNP
rs1269073769 1470 dbSNP
rs1224661007 1479 dbSNP
rs998169326 1482 dbSNP
rs558422227 1485 dbSNP
rs1422390640 1487 dbSNP
rs541268454 1491 dbSNP
rs1051109093 1494 dbSNP
rs889894400 1497 dbSNP
rs1162576961 1510 dbSNP
rs776572885 1513 dbSNP
rs1167381540 1523 dbSNP
rs1365800711 1524 dbSNP
rs1003834857 1526 dbSNP
rs1474483002 1530 dbSNP
rs1374968110 1553 dbSNP
rs1194176401 1556 dbSNP
rs1468275285 1559 dbSNP
rs1426391633 1564 dbSNP
rs1216019404 1566 dbSNP
rs1033910704 1573 dbSNP
rs1469280597 1576 dbSNP
rs959585210 1577 dbSNP
rs1017442885 1580 dbSNP
rs984716156 1580 dbSNP
rs1270352845 1581 dbSNP
rs376493948 1590 dbSNP
rs774746599 1595 dbSNP
rs961427856 1605 dbSNP
rs1305315538 1606 dbSNP
rs1441424912 1611 dbSNP
rs138321077 1614 dbSNP
rs1326813520 1616 dbSNP
rs1408218199 1617 dbSNP
rs1169374447 1621 dbSNP
rs553875032 1621 dbSNP
rs1243844749 1623 dbSNP
rs950351325 1625 dbSNP
rs992518419 1645 dbSNP
rs916979439 1651 dbSNP
rs140967130 1652 dbSNP
rs1180301650 1654 dbSNP
rs17477864 1655 dbSNP
rs1273088569 1658 dbSNP
rs926140710 1667 dbSNP
rs1282521595 1670 dbSNP
rs1345261331 1671 dbSNP
rs374389816 1672 dbSNP
rs1234705363 1677 dbSNP
rs911150602 1677 dbSNP
rs1194465123 1688 dbSNP
rs542780049 1691 dbSNP
rs1444283057 1699 dbSNP
rs1442287705 1702 dbSNP
rs989008333 1716 dbSNP
rs935909056 1718 dbSNP
rs1308683895 1722 dbSNP
rs1434238079 1736 dbSNP
rs1175762840 1737 dbSNP
rs1415343761 1740 dbSNP
rs1054696714 1741 dbSNP
rs913508851 1742 dbSNP
rs1471422694 1770 dbSNP
rs933967934 1770 dbSNP
rs1253227405 1773 dbSNP
rs771040435 1777 dbSNP
rs889832608 1778 dbSNP
rs1259102689 1786 dbSNP
rs1010098303 1787 dbSNP
rs150216153 1796 dbSNP
rs1316030376 1798 dbSNP
rs1281884309 1804 dbSNP
rs1225296632 1810 dbSNP
rs906554209 1811 dbSNP
rs368508986 1816 dbSNP
rs1033658789 1822 dbSNP
rs1414172725 1827 dbSNP
rs541562397 1828 dbSNP
rs1005769906 1834 dbSNP
rs1353659017 1838 dbSNP
rs1383921039 1838 dbSNP
rs1017555850 1839 dbSNP
rs560846573 1840 dbSNP
rs994703358 1841 dbSNP
rs1402825041 1845 dbSNP
rs972918932 1848 dbSNP
rs1026218432 1852 dbSNP
rs1164844831 1856 dbSNP
rs559810508 1858 dbSNP
rs1013899715 1861 dbSNP
rs1023981907 1863 dbSNP
rs1485323714 1876 dbSNP
rs955096447 1888 dbSNP
rs1403797769 1891 dbSNP
rs527347788 1895 dbSNP
rs985109400 1896 dbSNP
rs1272407924 1897 dbSNP
rs1231365161 1898 dbSNP
rs1336938641 1901 dbSNP
rs1295168859 1903 dbSNP
rs552745271 1905 dbSNP
rs555946677 1913 dbSNP
rs1229009690 1919 dbSNP
rs1361468887 1924 dbSNP
rs1033203970 1930 dbSNP
rs570925249 1934 dbSNP
rs1389862617 1935 dbSNP
rs3738829 1938 dbSNP
rs138750490 1939 dbSNP
rs990074439 1944 dbSNP
rs913093888 1945 dbSNP
rs945880446 1947 dbSNP
rs1042522244 1955 dbSNP
rs577465723 1965 dbSNP
rs1449757622 1971 dbSNP
rs939380452 1973 dbSNP
rs1270652613 1976 dbSNP
rs1211630735 1979 dbSNP
rs543693855 1981 dbSNP
rs1469744133 1983 dbSNP
rs1265979859 1986 dbSNP
rs879061562 2001 dbSNP
rs1222344545 2003 dbSNP
rs1306995287 2005 dbSNP
rs1293632147 2008 dbSNP
rs942732186 2016 dbSNP
rs766709018 2019 dbSNP
rs535840325 2026 dbSNP
rs1547715 2028 dbSNP
rs895141937 2031 dbSNP
rs1303094877 2047 dbSNP
rs1179272304 2053 dbSNP
rs1439225562 2066 dbSNP
rs1397264813 2089 dbSNP
rs1294664218 2090 dbSNP
rs566181549 2098 dbSNP
rs1460986103 2100 dbSNP
rs186459996 2103 dbSNP
rs1352244403 2114 dbSNP
rs898600055 2115 dbSNP
rs754841610 2117 dbSNP
rs1017168724 2126 dbSNP
rs1470424094 2128 dbSNP
rs539509223 2129 dbSNP
rs930440027 2133 dbSNP
rs553691263 2142 dbSNP
rs1479652159 2154 dbSNP
rs778886900 2163 dbSNP
rs1207436373 2173 dbSNP
rs558737098 2178 dbSNP
rs955127400 2179 dbSNP
rs538946313 2181 dbSNP
rs886323480 2183 dbSNP
rs748074781 2188 dbSNP
rs1302516206 2189 dbSNP
rs1391315297 2194 dbSNP
rs1547714 2195 dbSNP
rs1024676405 2196 dbSNP
rs1397823843 2212 dbSNP
rs1327159744 2216 dbSNP
rs1335381952 2217 dbSNP
rs1017927991 2219 dbSNP
rs1171366143 2220 dbSNP
rs1051473 2222 dbSNP
rs990494187 2223 dbSNP
rs1158194057 2224 dbSNP
rs1001631566 2232 dbSNP
rs556030246 2235 dbSNP
rs1252647289 2239 dbSNP
rs1184377280 2241 dbSNP
rs556249555 2242 dbSNP
rs1223395051 2243 dbSNP
rs1264266771 2244 dbSNP
rs1256998068 2249 dbSNP
rs1483975562 2253 dbSNP
rs12074798 2255 dbSNP
rs957131041 2256 dbSNP
rs988903973 2260 dbSNP
rs1020410764 2264 dbSNP
rs770504658 2267 dbSNP
rs945933471 2268 dbSNP
rs1354281560 2271 dbSNP
rs1310603491 2275 dbSNP
rs541424968 2281 dbSNP
rs1402524241 2282 dbSNP
rs1288051835 2283 dbSNP
rs764312669 2288 dbSNP
rs1365427570 2291 dbSNP
rs955575596 2294 dbSNP
rs928420545 2296 dbSNP
rs1185948191 2298 dbSNP
rs939452500 2298 dbSNP
rs1055213914 2305 dbSNP
rs1480085441 2316 dbSNP
rs1177111595 2317 dbSNP
rs1257151050 2318 dbSNP
rs1204874498 2336 dbSNP
rs1485097535 2342 dbSNP
rs895162385 2346 dbSNP
rs1229531463 2352 dbSNP
rs1334842030 2353 dbSNP
rs941358190 2355 dbSNP
rs1467696681 2356 dbSNP
rs1340655958 2369 dbSNP
rs1166168373 2378 dbSNP
rs866917269 2385 dbSNP
rs776296656 2390 dbSNP
rs190346479 2396 dbSNP
rs930053833 2398 dbSNP
rs897424378 2399 dbSNP
rs994340241 2405 dbSNP
rs1321048002 2408 dbSNP
rs1047556323 2419 dbSNP
rs907701487 2427 dbSNP
rs1162819918 2448 dbSNP
rs768955679 2450 dbSNP
rs1029793172 2453 dbSNP
rs891285152 2455 dbSNP
rs774893183 2463 dbSNP
rs949892345 2465 dbSNP
rs1250281310 2484 dbSNP
rs1284550440 2494 dbSNP
rs565570210 2497 dbSNP
rs182154076 2498 dbSNP
rs1271855752 2499 dbSNP
rs1001178822 2500 dbSNP
rs200948533 2504 dbSNP
rs1018003287 2510 dbSNP
rs1356444264 2511 dbSNP
rs1250206842 2521 dbSNP
rs1224775082 2525 dbSNP
rs1339683182 2534 dbSNP
rs754441046 2536 dbSNP
rs1367001621 2541 dbSNP
rs1298030453 2550 dbSNP
rs957290941 2552 dbSNP
rs149344675 2584 dbSNP
rs1020334610 2591 dbSNP
rs1266283856 2596 dbSNP
rs772645114 2603 dbSNP
rs370046968 2605 dbSNP
rs1490137842 2609 dbSNP
rs1199862143 2610 dbSNP
rs1167474258 2611 dbSNP
rs1269454346 2613 dbSNP
rs1428034308 2624 dbSNP
rs892845576 2630 dbSNP
rs1009936109 2632 dbSNP
rs113518918 2641 dbSNP
rs1251606877 2646 dbSNP
rs955527298 2651 dbSNP
rs981351188 2653 dbSNP
rs1271677127 2660 dbSNP
rs1372541271 2668 dbSNP
rs928492817 2674 dbSNP
rs1170771478 2678 dbSNP
rs1018506170 2685 dbSNP
rs1424504592 2689 dbSNP
rs1345480339 2701 dbSNP
rs1276452989 2703 dbSNP
rs1437099778 2705 dbSNP
rs1335137616 2708 dbSNP
rs1328245872 2709 dbSNP
rs7473 2710 dbSNP
rs144857778 2718 dbSNP
rs1434428736 2719 dbSNP
rs1380976361 2727 dbSNP
rs919927906 2738 dbSNP
rs1294267817 2744 dbSNP
rs1174749784 2745 dbSNP
rs916683679 2745 dbSNP
rs1232831027 2749 dbSNP
rs941419721 2751 dbSNP
rs1289216948 2757 dbSNP
rs1483752596 2765 dbSNP
rs1252014035 2778 dbSNP
rs1209686778 2783 dbSNP
rs1038375110 2793 dbSNP
rs918547519 2799 dbSNP
rs1349812177 2802 dbSNP
rs562366142 2803 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gcggcAGGGCCCUCGGGGUGAGu 5'
               |::|  || |||||||| 
Target 5' -----UUUC-AGACCCCCACUCc 3'
 		1 - 17
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_002293 | 3UTR | AGACCCCCACUCCUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_002293 | 3UTR | AGACCCCCACUCCUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000258341.4 | 3UTR | UUUCAGACCCCCACUCCUCUGCUGCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
85 hsa-miR-4745-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT100716 TJAP1 tight junction associated protein 1 2 2
MIRT183592 ZC3H11A zinc finger CCCH-type containing 11A 2 2
MIRT338035 DAZAP2 DAZ associated protein 2 2 4
MIRT395801 SPCS3 signal peptidase complex subunit 3 2 2
MIRT443946 LRIT3 leucine rich repeat, Ig-like and transmembrane domains 3 2 2
MIRT450579 HIST1H2BG histone cluster 1 H2B family member g 2 6
MIRT451616 MEIS3P1 Meis homeobox 3 pseudogene 1 2 2
MIRT452330 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT453278 EFTUD2 elongation factor Tu GTP binding domain containing 2 2 2
MIRT455213 GNL1 G protein nucleolar 1 (putative) 2 2
MIRT455469 LYPLA2 lysophospholipase II 2 2
MIRT456502 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 2 2
MIRT456686 LDB1 LIM domain binding 1 2 2
MIRT456914 DDA1 DET1 and DDB1 associated 1 2 2
MIRT457602 IDS iduronate 2-sulfatase 2 2
MIRT457849 RNASEH2B ribonuclease H2 subunit B 2 4
MIRT458454 RPRM reprimo, TP53 dependent G2 arrest mediator homolog 2 2
MIRT460178 UNK unkempt family zinc finger 2 6
MIRT461464 SLC19A3 solute carrier family 19 member 3 2 2
MIRT464738 UBE2Q1 ubiquitin conjugating enzyme E2 Q1 2 2
MIRT465278 TRIM28 tripartite motif containing 28 2 2
MIRT468449 SETD1B SET domain containing 1B 2 2
MIRT468619 SUMO1 small ubiquitin-like modifier 1 2 6
MIRT469151 RNF121 ring finger protein 121 2 2
MIRT470072 PTGES2 prostaglandin E synthase 2 2 2
MIRT470171 PSMD11 proteasome 26S subunit, non-ATPase 11 2 4
MIRT473155 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT474307 LAMC1 laminin subunit gamma 1 2 2
MIRT474781 KIAA0895L KIAA0895 like 2 2
MIRT476482 GATAD2A GATA zinc finger domain containing 2A 2 2
MIRT477612 EFNA3 ephrin A3 2 2
MIRT479523 CDCA4 cell division cycle associated 4 2 2
MIRT479972 CARD10 caspase recruitment domain family member 10 2 2
MIRT480409 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT480425 C17orf85 nuclear cap binding subunit 3 2 2
MIRT483571 SYT2 synaptotagmin 2 2 2
MIRT483663 QSOX2 quiescin sulfhydryl oxidase 2 2 4
MIRT484531 POLD3 DNA polymerase delta 3, accessory subunit 2 2
MIRT484614 SIX3 SIX homeobox 3 2 6
MIRT485896 ZFP36 ZFP36 ring finger protein 2 2
MIRT486504 MYH11 myosin heavy chain 11 2 2
MIRT487506 GRK5 G protein-coupled receptor kinase 5 2 2
MIRT488851 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT489463 MSC musculin 2 2
MIRT491168 LRP3 LDL receptor related protein 3 2 2
MIRT496626 TMEM67 transmembrane protein 67 2 2
MIRT497615 ANG angiogenin 2 2
MIRT497765 KIAA0895 KIAA0895 2 2
MIRT499679 MRE11A MRE11 homolog, double strand break repair nuclease 2 6
MIRT499772 SLC29A2 solute carrier family 29 member 2 2 2
MIRT501744 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT504993 ZNF652 zinc finger protein 652 2 2
MIRT511663 HIST1H3C histone cluster 1 H3 family member c 2 2
MIRT511689 HIST1H2BO histone cluster 1 H2B family member o 2 4
MIRT511702 HIST1H2BL histone cluster 1 H2B family member l 2 4
MIRT511733 HIST1H2BE histone cluster 1 H2B family member e 2 8
MIRT512857 TBC1D13 TBC1 domain family member 13 2 2
MIRT513443 EMP1 epithelial membrane protein 1 2 6
MIRT515680 TFPI tissue factor pathway inhibitor 2 2
MIRT523528 GLUL glutamate-ammonia ligase 2 2
MIRT525545 PHB2 prohibitin 2 2 4
MIRT526208 SNX24 sorting nexin 24 2 2
MIRT531555 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT533763 TMEM135 transmembrane protein 135 2 2
MIRT545581 SNRPA1 small nuclear ribonucleoprotein polypeptide A' 2 2
MIRT552433 ZNF460 zinc finger protein 460 2 2
MIRT561158 BCL2L12 BCL2 like 12 2 2
MIRT562344 EXOSC2 exosome component 2 2 2
MIRT570658 KDM6B lysine demethylase 6B 2 2
MIRT571075 TCHHL1 trichohyalin like 1 2 2
MIRT571331 TPCN2 two pore segment channel 2 2 2
MIRT571601 TOB2 transducer of ERBB2, 2 2 2
MIRT573012 RPP25 ribonuclease P and MRP subunit p25 2 2
MIRT609042 EP300 E1A binding protein p300 2 2
MIRT613397 DNAH17 dynein axonemal heavy chain 17 2 2
MIRT635588 TTC9C tetratricopeptide repeat domain 9C 2 2
MIRT644753 TXNRD3NB thioredoxin reductase 3 neighbor 2 2
MIRT661117 FPR1 formyl peptide receptor 1 2 2
MIRT690102 PNMA2 paraneoplastic Ma antigen 2 2 2
MIRT694971 PLAC8 placenta specific 8 2 2
MIRT695514 ALPI alkaline phosphatase, intestinal 2 2
MIRT695576 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT699569 SIT1 signaling threshold regulating transmembrane adaptor 1 2 2
MIRT701990 MIER3 MIER family member 3 2 2
MIRT725462 GRAP2 GRB2-related adaptor protein 2 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4745-5p Cisplatin approved 84093 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4745 Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4745 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4745 Plx-4720 24180719 NSC757438 sensitive High Thyroid Cancer cell line (8505c, BCPAP)
hsa-mir-4745 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-4745 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4745 Androstenedione+Anastrozole sensitive cell line (MCF-7)
hsa-mir-4745 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-4745-5p Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4745-5p Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4745-5p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4745-5p Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4745-5p Curcumin 969516 NSC32982 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4745-5p Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4745-5p Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-4745-5p Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (H460)
hsa-miR-4745-5p Docetaxel 148124 NSC628503 approved sensitive High Breast Cancer cell line (MDA-MB-231, MCF-7)
hsa-miR-4745-5p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-4745-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-4745-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-4745-5p Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (cytosolic RNA)
hsa-miR-4745-5p Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (total RNA)
hsa-miR-4745-5p Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-4745-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4745-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-4745-5p Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-4745-5p Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-4745-5p Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-4745-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4745-5p Gemcitabine 60750 NSC613327 approved resistant cell line (MDA-231)
hsa-miR-4745-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4745-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4745-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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