miRTarBase - #MIRT474612


—
pre-miRNA Information
pre-miRNA hsa-mir-4708   
Genomic Coordinates chr14: 65335117 - 65335183
Description Homo sapiens miR-4708 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4708-5p
Sequence 9| AGAGAUGCCGCCUUGCUCCUU |29
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1017378847 9 dbSNP
rs750825813 10 dbSNP
rs1297395738 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol KLF3   
Synonyms BKLF
Description Kruppel like factor 3
Transcript NM_016531   
Expression
Putative miRNA Targets on KLF3
3'UTR of KLF3
(miRNA target sites are highlighted)		 
>KLF3|NM_016531|3'UTR
   1 TTGCCTCTGTGTCCTGCCTCAGCGTGACTCCCCACTCACCTGGCTCTCTCTCTGTCCTGCCTCCCATTATCTAACACATT
  81 TTTTACATGTACATTTTAATTTGATTCAGCTGGTCTGAATCTCTGAATTTATATCATCCAAAACTTCCATATGGTCAGTA
 161 GTAGATGTTCTCTAATCCTCCCTCTCCTTACCACGGGTCAGACCTAAAGAATGTGAACACTTTTTTTTTTTTTTCTGGGG
 241 ATGCTAAGCAAACCCTTCTTACAGATACGTTTAATGTAATAAGAACAAGGGAACATGTAAACTAACATAACCAATTGTCA
 321 GTTCTCCATGTATTCCTCAAAAGAATGTCAGAGTAAATGTATTAGAAATACAGTATCCAGACTGCTAGTCCTTGCCAGAG
 401 ACATTCTTACCTCTGCCCTGTGATAATATTTTATGCTTGACAGTGAAAACAAGTGTGGCCCCTTGCACCGGTTAGCTAGA
 481 AGTACAGCCAGATTTCAAGCTAGTGCAGTCACCTCTTCCGTCATTCTTCACAAATCTTGTCAACCTGGATCTTAGACTTC
 561 ATCTGAATCGAGTTCTTTGCCCTCCTTTGTGCCTGCAGCTCATATGGAGGTCTTTGCCACCAATGGGAGATGAGCCCAAA
 641 CTTTCGATCTAGGTGGGTGATGTGTAGCAGTTCAAGGGAAGGGTGCTGTGTTTTCATAGCATGGAGTCGGAGGAGAGGGC
 721 CATTTAGCAGGGGGAGCAGAAGAGGCAATTCCTCCTGGGCTAGGGGTTGTCAGTGAGGTTTCAACATTTTGTTAGCTGTG
 801 TGCAGCATTCCCAGAGCTTCAGTCTCTGTGCATACTCAGCTTTGTAGAACCATGCTGCAAAGCCATATACCGATGGGGTT
 881 ATCCATGCAACTATCTCCATTCCTACAATGTCCTTAATATGAGATCATCAAACATTGATAGTAGGGACTCCATGGAATAT
 961 TTGCCCAGTAATGGTAAGAAATCTTTCGGGTAAGAGTATGGATGGTTCTTCTTTTACCCAATCTGCTTATAGCTTTTTTT
1041 GTAAACAGGGAAATGTTGAGTGGTACTTGTATTCCCTTATCAAATTAATCACATAGCTTTTATACAGAAACTCTTCCTGT
1121 GTGAGCTGTTAAGGTGCCAAATTGGCTGTCATTTGTATTCATGACACATACCATAAAGCATCTGCTAATGCTTTAATGGA
1201 TTGATTCAATTAAGACCTGAGTGACACTATTTGTAAATATAACTAGTTGTGAAGCACACATACCTTTATTTTGGGAATTT
1281 ATGAGAAAATATAGAAAACCACAGATCAGGGATTCATATATGTAGCTCAAAAATTCCCAAAAGTTTACTGTTAGAGTTGG
1361 CAATTTCCTATCACTATTTCAGTGTCAGAACAAACTGAAAATAATGGCTCGTGTTTATGTTGAAGATAAATAGCACCATT
1441 ATTGGGGGAAGTTATTCAAAAGCAGGCTTTTGAGCACCATAGTCTAAATGCCAATAAAAATAATTCATACATAGAAATGT
1521 CATTGGTCCTGAATTTGAAGAAAGTGAGCAACAGTAGTTAAATGTGGGTGCATATAACCAAATTCCCCTTCATCAAGAAT
1601 GGAGGAGAAGAGAGAAGAATGAAATCCTGAAGATTCATCCCAGCCGCAACTCAGGATCCAACACAACTTTAACTGGGAGG
1681 AATACATTGTTTGATCATTTTTAAAACATCTGTGAATGAGTGATTCCGGAGGCCTGTGAATTGTGTGGGGAGCTTGCTTT
1761 GATGGCACTGTGTTAATAAAAGTTGTAGGGACTGTGCACCTAAGAGGCTAAGAGGTCCCACTCATCCGCCCTGTGAACCA
1841 GCTGTAAAGAAATGTAGTTAAGAAATGCAAAGAAATGTGTTATCTTGGCACTTGGGTTTGATTTTCCTTTTTTTAAAGCA
1921 CTGCAAAACTTCTTTAGGATACTAAAACATCCTAATTGGGCTGTTTTTTTGTTTTGTTTTGTTTTTCAGCTAAAGGCAAA
2001 GATAATTTTTTTTTCAGCTGAAGTTTTTCTTTTTTGCAACTATGACATGAATTGAGTGATAAAATGGCTCTTTGAAAAGT
2081 AGATATTGTCTGTATTGTAAATGCTTAGTCATATTCATGGCAAAGTGTTCATTTCTTGAGATGGTTCTTTCACAACACAC
2161 AAGAATCAAGATGGAACGCAAGGAAAATCTTTTTGTTTTGACCGAGGTAACCAGTTTATGTGTGTTCCAATCCATAGAGA
2241 AGTGGGGGAAAGGGCGAGAAAGGATCAGATTGATCTGGGATCAGCTTTGAGCCTGAGTTCAGTGAATAGCCTCATGGGCA
2321 TCTCATGGAATTGATGCATTTGCTGTGGCATATTTAAATTTTGTTCAAAAGATTTGAAGCAAGACCTTGCAAAGACTCTT
2401 AACATTACTGTTCAGCTTGCTTAGATTGTGTTAACAGTTCATTTAACAAAGATCCGTTTTAACTCTGAACAAAAGCAACC
2481 CAGAGCGGCCATTCTCTATTCCCATGCTGGTCAATACGCTTTCATTACCAATTGGCCCTTACCAAACTTTTCTTATATAT
2561 ATATTTGTATTTTACTATGATAGTTGAGAAATTTAGCCTCTTAGTCATTTTTAGCTGTTATTGTGGAAGACCTCAAATAC
2641 AAGATTAGATGCCCTTGAACATGTTTTAATGATGTGTGTCATGTTACTATCAATGGTGATTTCAATCGCAATATTTTAAA
2721 TTGATGAGAATGATTTGTAAACATGAAGTTACTATTACGTAAATTCTGTTTGTTATAGAGTTTCTTCAGTTGTTACCCAA
2801 GTGTCATCCTAGAGAAGTCAGAAGAATCAGAATCCATCGTATTTTAGAGTTATGTGAATCTACATCATAAATGGGCATTA
2881 ACATTCTAAATTGCTTGGTTTGGAGAATGTGTTAGCAGCATAGCTATATTCAACTAGGGAGATGCTAAATACACAGAAGT
2961 TTCAAGAGCCTTGGAACAGAATTACAGGGGAACTATATATGTATATGTATATTTTATTAAACACCCATCTGCACTATCAG
3041 TATTGCACTAATGTGGAATTTGAAAGACTATTTTGCTGATACTGTATATATGCGCATCATTCCTGATTAGATTGTTGTAA
3121 AGACAATCTGAAAGATCTAAGGTTTTAAAATAATTTGGTTTGAAAATATACAGTTGTCTTGAAGGAATTGCTGTCATACA
3201 TGAAGTTGCTCCGAGCTGTCTTTATTCTCTTCTTGGTCAAGGTTAACAATTGCTAAATGATCGCAAATTCACCTAAACAA
3281 TACATTTACAAAGCCATCTTTACATGCATTAAACGAGGGCTACAACAATATTGTTTTACAAATACTAGCACTTTTTTTTC
3361 TGTTATGTACTTAGTGTTAGAGGGTCAAAATAATCTTTCTGCTTAGCATCTCTTAAACCATACCTGCAAATATAGCAGGA
3441 TTATTACATTTACAGTACTTTAATACTTGTATAAACTATGCAGAAATTTTTAATAAAGTGTAATATATTTTATAAGCTAA
3521 TAAGACTGAATGGGTAAAGGTTTTTAGCATGCATTAGTATACTTGCAGATACTGAAACATTTTGGTAATCTTTCTTACTA
3601 AAGATGTGAATGTTTAATGTACCTTCTCTGTTTCTACTCTGTAGTCCAATGGGAATTCAGTAATGACATTTTGTCATGTC
3681 AAACTGTGAACATAAATTTGTACTGTACAGTCCTCATATACTATATACAGTATGCAATATATATTATATACTTGTTAATA
3761 AAACCATCAGAATATTAAATGTGATCATGTGATTACTTCATATGCAGTGATCACTAGAGCAAAACTTACAGAGCAATGTA
3841 AGAACCCTTGCTTAGAACATTACTTACTCTGATGGGCAGTTATTGTTGATGGAGGGACAGAAAAATAGATCTAACTGGAA
3921 GATGAACTACCGGAATTAACTCAGCCCTCAAGCTATGTCCCTGGTTTTCTGAAAACAGCCAACAGGAAGTCTCCTAGGCT
4001 GAAATCATAAAACTGCAGACAATCCAGCAAAAATCTACAAACTCACCTAGTTCATTCTTGAAATACTTCTTGTATTTGTT
4081 ATTTATGAACCCCTGCCTGCTTCCAAAAAGAACTTGCAGCATTTTGTATTAAAAGACGCATGTGTATAATACTTTAAACT
4161 TTTAGAGTAAAATATCAAGACTCTCATGTTGGGGAGTGGGGAACGAGGAACAGAACAATAACGCATTAAAGTAAATAACT
4241 CTGGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uuccucGUUCCGCCGUAGAGa 5'
                || |  |||||||| 
Target 5' tagcctCATG--GGCATCTCa 3'
 2307 - 2325 147.00 -12.40
2 
miRNA  3' uuccucguuccgcCGUAGAGa 5'
                       ||||||| 
Target 5' atctttctgcttaGCATCTCt 3'
 3393 - 3413 140.00 -10.60
3 
miRNA  3' uuccUCGUUCCGCCGUAGAGa 5'
              ||| :| | | ||||| 
Target 5' attcAGCTGGTCTGAATCTCt 3'
 104 - 124 125.00 -10.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31606062 24 COSMIC
COSN26981651 53 COSMIC
COSN26981652 54 COSMIC
COSN31510151 64 COSMIC
COSN31598763 91 COSMIC
COSN29382965 116 COSMIC
COSN22208199 165 COSMIC
COSN20069325 235 COSMIC
COSN27233428 235 COSMIC
COSN31546608 269 COSMIC
COSN31542997 327 COSMIC
COSN16376236 532 COSMIC
COSN6830154 565 COSMIC
COSN7489901 700 COSMIC
COSN23987490 774 COSMIC
COSN6830155 925 COSMIC
COSN31594746 1123 COSMIC
COSN9039867 1392 COSMIC
COSN2027813 1575 COSMIC
COSN7638506 1592 COSMIC
COSN5570644 1810 COSMIC
COSN23609038 2179 COSMIC
COSN26846779 2499 COSMIC
COSN22210710 2760 COSMIC
COSN16389629 2776 COSMIC
COSN22175834 2839 COSMIC
COSN25802577 2934 COSMIC
COSN9039869 3019 COSMIC
COSN24372597 3080 COSMIC
COSN16880760 3229 COSMIC
COSN29788078 3239 COSMIC
COSN23201003 3360 COSMIC
rs36023504 41 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs767869375 5 dbSNP
rs1174596754 6 dbSNP
rs998247701 10 dbSNP
rs1212764242 11 dbSNP
rs1426248362 16 dbSNP
rs369314304 18 dbSNP
rs769004180 18 dbSNP
rs1434496578 19 dbSNP
rs759408097 24 dbSNP
rs765056367 25 dbSNP
rs955459166 25 dbSNP
rs752729204 28 dbSNP
rs1327567374 31 dbSNP
rs757834451 33 dbSNP
rs951087860 36 dbSNP
rs1275085290 38 dbSNP
rs1346794802 39 dbSNP
rs1231845933 40 dbSNP
rs36023504 41 dbSNP
rs762277039 44 dbSNP
rs778125232 44 dbSNP
rs1174819621 46 dbSNP
rs1342755838 47 dbSNP
rs756852332 49 dbSNP
rs779481357 51 dbSNP
rs1268554147 53 dbSNP
rs957883759 54 dbSNP
rs1484135414 62 dbSNP
rs990360544 66 dbSNP
rs1356571618 70 dbSNP
rs1016727272 79 dbSNP
rs183492702 84 dbSNP
rs970208739 88 dbSNP
rs973620013 92 dbSNP
rs1220823701 93 dbSNP
rs927521932 127 dbSNP
rs1282357321 138 dbSNP
rs1203735975 142 dbSNP
rs541390936 144 dbSNP
rs937620505 145 dbSNP
rs1445463964 148 dbSNP
rs929058076 153 dbSNP
rs189476752 161 dbSNP
rs1420885356 167 dbSNP
rs1413195734 180 dbSNP
rs1429062230 182 dbSNP
rs574783243 185 dbSNP
rs116518864 187 dbSNP
rs563447161 193 dbSNP
rs1038976095 195 dbSNP
rs1176824427 207 dbSNP
rs1041778658 210 dbSNP
rs1408109921 220 dbSNP
rs1212196589 221 dbSNP
rs759143242 221 dbSNP
rs1452896950 222 dbSNP
rs900378558 230 dbSNP
rs1313837289 231 dbSNP
rs532433309 235 dbSNP
rs1380165967 236 dbSNP
rs1224920070 238 dbSNP
rs1307147929 239 dbSNP
rs1304037156 241 dbSNP
rs997366701 244 dbSNP
rs1316816317 253 dbSNP
rs28599637 254 dbSNP
rs935816844 259 dbSNP
rs1461998641 260 dbSNP
rs1343744275 262 dbSNP
rs377094028 264 dbSNP
rs899719877 269 dbSNP
rs1481752998 270 dbSNP
rs1180243697 278 dbSNP
rs998132575 280 dbSNP
rs1029298075 284 dbSNP
rs1444050948 289 dbSNP
rs1177828305 293 dbSNP
rs998933862 294 dbSNP
rs771115126 304 dbSNP
rs77979101 306 dbSNP
rs1418424660 315 dbSNP
rs1214672008 322 dbSNP
rs375970117 323 dbSNP
rs776747383 325 dbSNP
rs572736916 329 dbSNP
rs1431360416 333 dbSNP
rs759893807 336 dbSNP
rs1243229265 338 dbSNP
rs748467947 343 dbSNP
rs758829690 350 dbSNP
rs1335865603 360 dbSNP
rs962480108 362 dbSNP
rs1443981229 366 dbSNP
rs770328256 370 dbSNP
rs973949756 381 dbSNP
rs1360356713 389 dbSNP
rs970260831 399 dbSNP
rs1458717503 404 dbSNP
rs1351880665 413 dbSNP
rs1034540835 418 dbSNP
rs981604571 419 dbSNP
rs547415168 432 dbSNP
rs1389196017 440 dbSNP
rs181082513 442 dbSNP
rs1424158436 443 dbSNP
rs1390798065 448 dbSNP
rs1189139026 451 dbSNP
rs959171011 452 dbSNP
rs1285666709 454 dbSNP
rs1451208333 466 dbSNP
rs993105135 469 dbSNP
rs950561241 470 dbSNP
rs184857080 471 dbSNP
rs149971564 476 dbSNP
rs746636652 479 dbSNP
rs189687733 481 dbSNP
rs1358112628 492 dbSNP
rs926026850 496 dbSNP
rs574505313 506 dbSNP
rs936113671 513 dbSNP
rs533813748 518 dbSNP
rs181504196 520 dbSNP
rs921109553 521 dbSNP
rs145674689 524 dbSNP
rs186149133 535 dbSNP
rs555012230 544 dbSNP
rs1371277916 546 dbSNP
rs1170513547 549 dbSNP
rs1052058450 551 dbSNP
rs558293839 552 dbSNP
rs902343315 561 dbSNP
rs999381141 565 dbSNP
rs887046260 566 dbSNP
rs1175406985 570 dbSNP
rs775960965 571 dbSNP
rs1270692304 576 dbSNP
rs1053218272 585 dbSNP
rs1422889009 590 dbSNP
rs574747678 599 dbSNP
rs1022892774 600 dbSNP
rs1251297127 608 dbSNP
rs1353562747 610 dbSNP
rs73808533 636 dbSNP
rs1223156254 642 dbSNP
rs898214014 647 dbSNP
rs556905339 648 dbSNP
rs1310052339 652 dbSNP
rs1001961205 653 dbSNP
rs1404923716 657 dbSNP
rs1395794071 663 dbSNP
rs576801826 664 dbSNP
rs1281766861 668 dbSNP
rs1297543314 669 dbSNP
rs1034895869 671 dbSNP
rs1364593976 673 dbSNP
rs1431195903 673 dbSNP
rs73808534 674 dbSNP
rs1412344051 677 dbSNP
rs1183515342 682 dbSNP
rs983984635 683 dbSNP
rs116618576 684 dbSNP
rs373984905 689 dbSNP
rs1463008103 696 dbSNP
rs113004258 698 dbSNP
rs1024495230 702 dbSNP
rs1330233804 703 dbSNP
rs967634417 709 dbSNP
rs568901912 710 dbSNP
rs1237073202 714 dbSNP
rs1335279705 723 dbSNP
rs1224788513 724 dbSNP
rs963093828 725 dbSNP
rs1490493027 734 dbSNP
rs977365502 735 dbSNP
rs925975881 739 dbSNP
rs957645735 743 dbSNP
rs974432644 745 dbSNP
rs77800130 747 dbSNP
rs1476234736 749 dbSNP
rs562337079 755 dbSNP
rs541172401 760 dbSNP
rs1362729190 761 dbSNP
rs1418287277 762 dbSNP
rs190863820 765 dbSNP
rs923822108 766 dbSNP
rs3209570 774 dbSNP
rs1465636318 791 dbSNP
rs1054006352 798 dbSNP
rs1164899349 801 dbSNP
rs908428637 803 dbSNP
rs1365729104 806 dbSNP
rs1286734976 810 dbSNP
rs541703759 824 dbSNP
rs541487048 827 dbSNP
rs1038000011 828 dbSNP
rs1203635746 831 dbSNP
rs148901110 833 dbSNP
rs1266232532 836 dbSNP
rs1002313869 838 dbSNP
rs1054882205 841 dbSNP
rs1380664337 842 dbSNP
rs1312846473 866 dbSNP
rs1044413982 870 dbSNP
rs1347466524 872 dbSNP
rs896250556 876 dbSNP
rs905863640 879 dbSNP
rs1003250820 883 dbSNP
rs1035947812 893 dbSNP
rs1383838432 894 dbSNP
rs1163472864 898 dbSNP
rs1014364366 900 dbSNP
rs181929101 909 dbSNP
rs187406004 914 dbSNP
rs999065907 915 dbSNP
rs963149725 921 dbSNP
rs974489897 922 dbSNP
rs190993457 924 dbSNP
rs1290935309 932 dbSNP
rs759675785 935 dbSNP
rs957390575 936 dbSNP
rs975843577 951 dbSNP
rs1315807881 953 dbSNP
rs1358748373 955 dbSNP
rs552509940 956 dbSNP
rs565765962 968 dbSNP
rs1220362200 970 dbSNP
rs1287589995 972 dbSNP
rs1245174323 987 dbSNP
rs1340042228 988 dbSNP
rs765293515 989 dbSNP
rs534912547 990 dbSNP
rs1406353918 991 dbSNP
rs1363192303 996 dbSNP
rs923900212 999 dbSNP
rs754780670 1003 dbSNP
rs753222711 1006 dbSNP
rs1429794135 1014 dbSNP
rs548725551 1020 dbSNP
rs182708041 1022 dbSNP
rs1216210330 1026 dbSNP
rs1166653724 1029 dbSNP
rs1183572917 1031 dbSNP
rs11558402 1042 dbSNP
rs1247584774 1045 dbSNP
rs989358303 1051 dbSNP
rs779264907 1056 dbSNP
rs778720333 1068 dbSNP
rs1447276988 1072 dbSNP
rs143570144 1077 dbSNP
rs1489906250 1077 dbSNP
rs915073257 1082 dbSNP
rs986607287 1084 dbSNP
rs1206005169 1089 dbSNP
rs1439625596 1094 dbSNP
rs759021923 1096 dbSNP
rs537372858 1097 dbSNP
rs1044467326 1103 dbSNP
rs1443407288 1107 dbSNP
rs1160974953 1108 dbSNP
rs1338541639 1115 dbSNP
rs939883172 1116 dbSNP
rs1401840045 1121 dbSNP
rs1225096679 1128 dbSNP
rs938712735 1130 dbSNP
rs1302145319 1132 dbSNP
rs1409967870 1133 dbSNP
rs1318071620 1143 dbSNP
rs973976931 1154 dbSNP
rs1355719474 1156 dbSNP
rs919879297 1162 dbSNP
rs1409853105 1163 dbSNP
rs752617126 1166 dbSNP
rs937676386 1168 dbSNP
rs1386985764 1183 dbSNP
rs1179092011 1187 dbSNP
rs1479641738 1189 dbSNP
rs376939165 1190 dbSNP
rs150978901 1191 dbSNP
rs1337566888 1196 dbSNP
rs886720443 1208 dbSNP
rs1382354039 1210 dbSNP
rs1445967984 1226 dbSNP
rs949157556 1228 dbSNP
rs73808535 1230 dbSNP
rs1202384175 1232 dbSNP
rs1437218845 1237 dbSNP
rs1263649196 1240 dbSNP
rs1205405762 1244 dbSNP
rs1321135766 1249 dbSNP
rs1282261605 1261 dbSNP
rs1374916165 1262 dbSNP
rs903370941 1273 dbSNP
rs1440804600 1276 dbSNP
rs1281392555 1281 dbSNP
rs11558403 1282 dbSNP
rs3733318 1286 dbSNP
rs1339260243 1292 dbSNP
rs1224334346 1293 dbSNP
rs1405736547 1295 dbSNP
rs1163701042 1296 dbSNP
rs1263768373 1302 dbSNP
rs899326377 1305 dbSNP
rs1033246078 1308 dbSNP
rs188178221 1318 dbSNP
rs1421056651 1319 dbSNP
rs1406034463 1320 dbSNP
rs893407117 1325 dbSNP
rs1473165099 1329 dbSNP
rs1028751138 1331 dbSNP
rs996829301 1357 dbSNP
rs200905443 1358 dbSNP
rs1243331080 1359 dbSNP
rs1460635931 1367 dbSNP
rs1184740821 1390 dbSNP
rs1318400877 1392 dbSNP
rs1281657272 1394 dbSNP
rs1222771670 1397 dbSNP
rs1382869207 1407 dbSNP
rs954589967 1411 dbSNP
rs1031724091 1412 dbSNP
rs956094626 1413 dbSNP
rs1031071858 1414 dbSNP
rs1343725160 1416 dbSNP
rs990351212 1418 dbSNP
rs1158643820 1421 dbSNP
rs1425399733 1423 dbSNP
rs1387099511 1426 dbSNP
rs986888510 1442 dbSNP
rs190192415 1449 dbSNP
rs989348341 1456 dbSNP
rs1015718973 1459 dbSNP
rs1186926206 1464 dbSNP
rs1486720733 1468 dbSNP
rs1240058424 1469 dbSNP
rs1359541094 1480 dbSNP
rs1293271807 1483 dbSNP
rs1243110111 1485 dbSNP
rs1359408293 1486 dbSNP
rs1296917853 1492 dbSNP
rs1384334879 1495 dbSNP
rs1360244014 1507 dbSNP
rs915124226 1523 dbSNP
rs573248334 1524 dbSNP
rs540882826 1530 dbSNP
rs974338587 1539 dbSNP
rs980547718 1542 dbSNP
rs1177635457 1543 dbSNP
rs1424058493 1557 dbSNP
rs927394301 1562 dbSNP
rs1171039793 1565 dbSNP
rs561035788 1566 dbSNP
rs1057154325 1569 dbSNP
rs16994727 1578 dbSNP
rs1490397216 1580 dbSNP
rs1336488744 1581 dbSNP
rs1441579322 1583 dbSNP
rs940989577 1586 dbSNP
rs937941589 1598 dbSNP
rs1287572267 1601 dbSNP
rs1037967320 1614 dbSNP
rs1224479668 1615 dbSNP
rs560377255 1619 dbSNP
rs1347659918 1620 dbSNP
rs1301517208 1629 dbSNP
rs1327035627 1633 dbSNP
rs1225095536 1634 dbSNP
rs1022233484 1639 dbSNP
rs1404470870 1642 dbSNP
rs116831164 1646 dbSNP
rs1343848787 1647 dbSNP
rs375498807 1648 dbSNP
rs1198431392 1654 dbSNP
rs1352568032 1655 dbSNP
rs1169749259 1665 dbSNP
rs1252251446 1667 dbSNP
rs1480638847 1671 dbSNP
rs1431051039 1672 dbSNP
rs1437840490 1673 dbSNP
rs1432099529 1682 dbSNP
rs73808536 1684 dbSNP
rs182768249 1686 dbSNP
rs1050556566 1687 dbSNP
rs1481731939 1687 dbSNP
rs145884765 1691 dbSNP
rs902295216 1697 dbSNP
rs934815775 1699 dbSNP
rs1009045906 1708 dbSNP
rs1223062066 1717 dbSNP
rs528158116 1725 dbSNP
rs1309172175 1726 dbSNP
rs956581448 1728 dbSNP
rs1010487741 1729 dbSNP
rs1397487407 1730 dbSNP
rs1409411239 1731 dbSNP
rs893363752 1732 dbSNP
rs1407944357 1742 dbSNP
rs1173855772 1756 dbSNP
rs1465192934 1759 dbSNP
rs969245939 1770 dbSNP
rs1183402770 1771 dbSNP
rs1416782547 1774 dbSNP
rs1238159403 1783 dbSNP
rs1184684466 1785 dbSNP
rs1462937922 1789 dbSNP
rs997508347 1793 dbSNP
rs927766004 1797 dbSNP
rs960188727 1805 dbSNP
rs879072039 1807 dbSNP
rs993315906 1815 dbSNP
rs187416018 1822 dbSNP
rs1335188786 1824 dbSNP
rs1283672853 1828 dbSNP
rs1330240897 1829 dbSNP
rs1230803632 1832 dbSNP
rs531793007 1844 dbSNP
rs907921429 1845 dbSNP
rs1395210977 1847 dbSNP
rs1385300574 1850 dbSNP
rs940690816 1859 dbSNP
rs1028287905 1862 dbSNP
rs1451008217 1865 dbSNP
rs769339806 1867 dbSNP
rs1379081196 1868 dbSNP
rs1339690333 1873 dbSNP
rs550344540 1878 dbSNP
rs1446920112 1882 dbSNP
rs1015669897 1894 dbSNP
rs961484252 1895 dbSNP
rs1490981839 1898 dbSNP
rs34529625 1908 dbSNP
rs920860445 1908 dbSNP
rs1200847317 1910 dbSNP
rs973906525 1911 dbSNP
rs1264141674 1915 dbSNP
rs1203548763 1920 dbSNP
rs932209954 1925 dbSNP
rs1050606949 1929 dbSNP
rs3796538 1931 dbSNP
rs114166963 1932 dbSNP
rs1195819891 1947 dbSNP
rs1447085225 1953 dbSNP
rs991151978 1957 dbSNP
rs1319882187 1958 dbSNP
rs1380127676 1959 dbSNP
rs572291133 1962 dbSNP
rs1359370794 1964 dbSNP
rs1303283014 1967 dbSNP
rs370879748 1967 dbSNP
rs533328310 1967 dbSNP
rs1383986563 1971 dbSNP
rs1163127284 1972 dbSNP
rs543745028 1972 dbSNP
rs1375101985 1977 dbSNP
rs376103172 1977 dbSNP
rs74766352 1979 dbSNP
rs75960688 1980 dbSNP
rs1191335280 1983 dbSNP
rs1021902388 1988 dbSNP
rs768081023 2002 dbSNP
rs1002071422 2006 dbSNP
rs1224913784 2006 dbSNP
rs970365609 2008 dbSNP
rs1227604463 2022 dbSNP
rs1339864649 2024 dbSNP
rs1271664451 2031 dbSNP
rs1216544214 2035 dbSNP
rs1034895795 2043 dbSNP
rs1406259871 2044 dbSNP
rs1363092227 2048 dbSNP
rs977755167 2061 dbSNP
rs1323516748 2071 dbSNP
rs138699386 2081 dbSNP
rs982598436 2085 dbSNP
rs192316519 2087 dbSNP
rs1477694899 2091 dbSNP
rs962093364 2096 dbSNP
rs973431130 2103 dbSNP
rs936442434 2105 dbSNP
rs1479502142 2118 dbSNP
rs539458018 2119 dbSNP
rs547753508 2122 dbSNP
rs920576651 2124 dbSNP
rs932262174 2125 dbSNP
rs768607190 2126 dbSNP
rs774096182 2128 dbSNP
rs944887019 2136 dbSNP
rs1052586158 2142 dbSNP
rs1297523958 2147 dbSNP
rs1364903190 2178 dbSNP
rs1326617875 2179 dbSNP
rs1442257519 2186 dbSNP
rs1054587848 2194 dbSNP
rs1227294906 2196 dbSNP
rs761673947 2204 dbSNP
rs1294745515 2205 dbSNP
rs1407217741 2218 dbSNP
rs776211702 2219 dbSNP
rs1468388167 2221 dbSNP
rs1360899277 2225 dbSNP
rs1424700376 2228 dbSNP
rs1177894660 2236 dbSNP
rs1222588442 2240 dbSNP
rs771001885 2245 dbSNP
rs1234590750 2246 dbSNP
rs1176627061 2249 dbSNP
rs1487804162 2250 dbSNP
rs946449083 2256 dbSNP
rs1043409542 2257 dbSNP
rs904859179 2267 dbSNP
rs1464602907 2268 dbSNP
rs1310112801 2276 dbSNP
rs1277469397 2285 dbSNP
rs1352149544 2286 dbSNP
rs142698924 2294 dbSNP
rs932868764 2295 dbSNP
rs1035353801 2298 dbSNP
rs776901737 2301 dbSNP
rs1387318640 2302 dbSNP
rs1445275212 2303 dbSNP
rs759715157 2307 dbSNP
rs375551928 2313 dbSNP
rs1446236685 2314 dbSNP
rs1358872066 2318 dbSNP
rs1160088160 2321 dbSNP
rs1402527666 2329 dbSNP
rs1405833997 2332 dbSNP
rs573278029 2333 dbSNP
rs1456370758 2335 dbSNP
rs535973575 2338 dbSNP
rs1290403744 2339 dbSNP
rs1385471267 2343 dbSNP
rs1015415298 2361 dbSNP
rs1008220308 2362 dbSNP
rs962145855 2364 dbSNP
rs1434108320 2367 dbSNP
rs1236544330 2373 dbSNP
rs1318042285 2382 dbSNP
rs1448261442 2384 dbSNP
rs368042050 2385 dbSNP
rs1037050637 2396 dbSNP
rs1384582386 2396 dbSNP
rs897223160 2405 dbSNP
rs1378827729 2414 dbSNP
rs1246009177 2415 dbSNP
rs1311451036 2416 dbSNP
rs1358833689 2423 dbSNP
rs1297700621 2437 dbSNP
rs1425371585 2441 dbSNP
rs995999634 2442 dbSNP
rs185685669 2448 dbSNP
rs986125914 2453 dbSNP
rs912142732 2456 dbSNP
rs765384495 2457 dbSNP
rs1186768444 2459 dbSNP
rs959461196 2471 dbSNP
rs1012121969 2477 dbSNP
rs566338538 2487 dbSNP
rs574727851 2488 dbSNP
rs1215345773 2492 dbSNP
rs112885146 2493 dbSNP
rs563579415 2499 dbSNP
rs923611224 2501 dbSNP
rs1181326447 2502 dbSNP
rs1254243850 2505 dbSNP
rs1043465752 2510 dbSNP
rs1216658930 2513 dbSNP
rs1338801517 2514 dbSNP
rs16994728 2518 dbSNP
rs868599325 2519 dbSNP
rs921741137 2520 dbSNP
rs932792154 2526 dbSNP
rs1056106976 2536 dbSNP
rs796072059 2550 dbSNP
rs1004116519 2554 dbSNP
rs1349210244 2556 dbSNP
rs912791278 2557 dbSNP
rs1037311694 2558 dbSNP
rs1421100123 2561 dbSNP
rs944293019 2562 dbSNP
rs1192409633 2564 dbSNP
rs1480481504 2573 dbSNP
rs1036997672 2575 dbSNP
rs1270351584 2577 dbSNP
rs897167088 2578 dbSNP
rs1488461976 2579 dbSNP
rs898324816 2582 dbSNP
rs1207131568 2594 dbSNP
rs1301738188 2597 dbSNP
rs1316382496 2601 dbSNP
rs1376272794 2607 dbSNP
rs1257664790 2611 dbSNP
rs995554838 2622 dbSNP
rs1048956463 2624 dbSNP
rs1299349610 2635 dbSNP
rs188949139 2637 dbSNP
rs559325339 2638 dbSNP
rs1012463769 2645 dbSNP
rs1024781493 2648 dbSNP
rs1366907886 2650 dbSNP
rs528057461 2655 dbSNP
rs999403964 2662 dbSNP
rs1030908511 2663 dbSNP
rs1008000773 2672 dbSNP
rs1470040557 2674 dbSNP
rs957937839 2679 dbSNP
rs1324536454 2680 dbSNP
rs1209747422 2684 dbSNP
rs989182949 2687 dbSNP
rs1251884907 2694 dbSNP
rs1029148663 2695 dbSNP
rs1180977364 2700 dbSNP
rs1456737700 2701 dbSNP
rs1237906718 2706 dbSNP
rs541947530 2709 dbSNP
rs1177882655 2712 dbSNP
rs1254483471 2718 dbSNP
rs1232702150 2722 dbSNP
rs1317535327 2730 dbSNP
rs1307624434 2734 dbSNP
rs966731391 2739 dbSNP
rs1252386829 2754 dbSNP
rs1472251599 2755 dbSNP
rs988401075 2755 dbSNP
rs1179711174 2757 dbSNP
rs985606041 2759 dbSNP
rs914120586 2760 dbSNP
rs1438443152 2765 dbSNP
rs1380196561 2775 dbSNP
rs752846415 2777 dbSNP
rs1174838725 2794 dbSNP
rs192632499 2797 dbSNP
rs926390656 2798 dbSNP
rs937764633 2800 dbSNP
rs1463029893 2811 dbSNP
rs1298303490 2830 dbSNP
rs1350379777 2831 dbSNP
rs944237577 2835 dbSNP
rs1056557485 2837 dbSNP
rs917587978 2839 dbSNP
rs531010933 2840 dbSNP
rs1285562628 2857 dbSNP
rs939967559 2859 dbSNP
rs1331822829 2862 dbSNP
rs1036959078 2879 dbSNP
rs918886751 2892 dbSNP
rs931288295 2898 dbSNP
rs1309506340 2899 dbSNP
rs1048402154 2901 dbSNP
rs889226211 2904 dbSNP
rs1007639238 2906 dbSNP
rs1367046789 2908 dbSNP
rs1187135658 2914 dbSNP
rs895196628 2919 dbSNP
rs1429379678 2927 dbSNP
rs1214614747 2935 dbSNP
rs1265605377 2935 dbSNP
rs1019396431 2938 dbSNP
rs966077722 2943 dbSNP
rs1210315546 2951 dbSNP
rs948165385 2958 dbSNP
rs1009946420 2959 dbSNP
rs1202867157 2967 dbSNP
rs1243761130 2971 dbSNP
rs1270968544 2973 dbSNP
rs550720417 2977 dbSNP
rs1046181076 2978 dbSNP
rs1478211162 2985 dbSNP
rs1190430985 2991 dbSNP
rs906366486 2994 dbSNP
rs1304313607 2996 dbSNP
rs1359276167 2996 dbSNP
rs545975240 2997 dbSNP
rs1422596765 3007 dbSNP
rs1030856409 3010 dbSNP
rs1163108623 3012 dbSNP
rs1168673828 3014 dbSNP
rs968245702 3023 dbSNP
rs893750929 3029 dbSNP
rs979600635 3037 dbSNP
rs1269632247 3039 dbSNP
rs1033791083 3049 dbSNP
rs1010962477 3050 dbSNP
rs959422862 3053 dbSNP
rs1305416771 3057 dbSNP
rs1028678623 3064 dbSNP
rs991916246 3069 dbSNP
rs917624699 3071 dbSNP
rs1339303501 3083 dbSNP
rs1273491661 3087 dbSNP
rs149636214 3092 dbSNP
rs763514181 3094 dbSNP
rs1323409921 3095 dbSNP
rs1410884111 3105 dbSNP
rs764697962 3118 dbSNP
rs965533414 3124 dbSNP
rs972921361 3127 dbSNP
rs751910731 3130 dbSNP
rs546957310 3133 dbSNP
rs918822232 3135 dbSNP
rs1477075613 3148 dbSNP
rs931598736 3154 dbSNP
rs972361713 3156 dbSNP
rs984488430 3160 dbSNP
rs1458071675 3161 dbSNP
rs1340058504 3170 dbSNP
rs566892609 3170 dbSNP
rs757624660 3171 dbSNP
rs1046460316 3177 dbSNP
rs906649371 3181 dbSNP
rs935151168 3183 dbSNP
rs1052290629 3193 dbSNP
rs1248303926 3213 dbSNP
rs1293796878 3214 dbSNP
rs1379729935 3215 dbSNP
rs1329774345 3221 dbSNP
rs893693182 3221 dbSNP
rs1452161272 3226 dbSNP
rs1220521440 3230 dbSNP
rs1407193681 3233 dbSNP
rs1010828839 3237 dbSNP
rs889617141 3238 dbSNP
rs943833680 3241 dbSNP
rs1029045489 3253 dbSNP
rs888779968 3255 dbSNP
rs1008607859 3256 dbSNP
rs1040462068 3258 dbSNP
rs1018688237 3264 dbSNP
rs1188741635 3276 dbSNP
rs1176605252 3277 dbSNP
rs199555942 3281 dbSNP
rs1457107523 3283 dbSNP
rs1389177941 3295 dbSNP
rs770934673 3297 dbSNP
rs1020901506 3298 dbSNP
rs961819741 3304 dbSNP
rs904138880 3309 dbSNP
rs994311942 3316 dbSNP
rs1307695643 3334 dbSNP
rs1025813702 3338 dbSNP
rs1033843305 3340 dbSNP
rs1380269071 3349 dbSNP
rs1286210018 3358 dbSNP
rs1446028934 3359 dbSNP
rs1405336120 3361 dbSNP
rs1321983288 3363 dbSNP
rs1347374445 3366 dbSNP
rs1436285059 3368 dbSNP
rs1358781273 3371 dbSNP
rs953042148 3374 dbSNP
rs1298926569 3375 dbSNP
rs1320093814 3382 dbSNP
rs1363312719 3385 dbSNP
rs1454624639 3389 dbSNP
rs535473310 3391 dbSNP
rs928867406 3396 dbSNP
rs984382296 3402 dbSNP
rs1414185496 3403 dbSNP
rs1183353176 3405 dbSNP
rs1471627728 3410 dbSNP
rs992697151 3414 dbSNP
rs1216780931 3437 dbSNP
rs1488952855 3444 dbSNP
rs1284514772 3457 dbSNP
rs1216477537 3459 dbSNP
rs1024739587 3466 dbSNP
rs1315333721 3468 dbSNP
rs1226936718 3470 dbSNP
rs961404005 3472 dbSNP
rs1279009137 3474 dbSNP
rs1401925761 3487 dbSNP
rs972415530 3497 dbSNP
rs1296288337 3498 dbSNP
rs1453024509 3498 dbSNP
rs919588837 3503 dbSNP
rs916854195 3513 dbSNP
rs146007189 3527 dbSNP
rs375136208 3527 dbSNP
rs1416737758 3528 dbSNP
rs1193851457 3535 dbSNP
rs969340520 3539 dbSNP
rs982104120 3546 dbSNP
rs555944975 3547 dbSNP
rs386673663 3553 dbSNP
rs985380591 3553 dbSNP
rs7147 3554 dbSNP
rs1318437872 3560 dbSNP
rs1219840646 3565 dbSNP
rs537254572 3567 dbSNP
rs1258982898 3573 dbSNP
rs1220641444 3574 dbSNP
rs1316266176 3586 dbSNP
rs1277686531 3589 dbSNP
rs1387420636 3593 dbSNP
rs1368285992 3594 dbSNP
rs935438124 3596 dbSNP
rs1209160875 3599 dbSNP
rs1052660413 3609 dbSNP
rs1434037974 3612 dbSNP
rs1393411972 3613 dbSNP
rs1170980823 3626 dbSNP
rs1466907584 3633 dbSNP
rs1246980809 3635 dbSNP
rs1169217641 3638 dbSNP
rs943906504 3642 dbSNP
rs34454712 3643 dbSNP
rs1270101384 3648 dbSNP
rs1189943518 3650 dbSNP
rs1488371242 3694 dbSNP
rs1041250451 3716 dbSNP
rs1200872707 3716 dbSNP
rs915088661 3738 dbSNP
rs1257645278 3740 dbSNP
rs1184873502 3742 dbSNP
rs1234070254 3742 dbSNP
rs1237617490 3744 dbSNP
rs1313959440 3746 dbSNP
rs1303363788 3748 dbSNP
rs1217361746 3750 dbSNP
rs1472750186 3752 dbSNP
rs946577966 3754 dbSNP
rs1331836881 3755 dbSNP
rs1042408604 3756 dbSNP
rs1161906330 3764 dbSNP
rs1050362139 3765 dbSNP
rs903856361 3773 dbSNP
rs1000789348 3785 dbSNP
rs1378812265 3788 dbSNP
rs1173316018 3805 dbSNP
rs1381464081 3817 dbSNP
rs889060948 3822 dbSNP
rs3816643 3828 dbSNP
rs1456674633 3837 dbSNP
rs895357574 3840 dbSNP
rs1158953166 3841 dbSNP
rs1040077515 3845 dbSNP
rs1484292542 3847 dbSNP
rs1254393663 3848 dbSNP
rs1209469621 3852 dbSNP
rs1013781387 3859 dbSNP
rs1242070391 3860 dbSNP
rs1309872837 3860 dbSNP
rs897538283 3863 dbSNP
rs1305877716 3870 dbSNP
rs1454841567 3875 dbSNP
rs961191782 3886 dbSNP
rs993267946 3893 dbSNP
rs993907670 3895 dbSNP
rs1026698500 3899 dbSNP
rs576473579 3899 dbSNP
rs755774246 3903 dbSNP
rs952906802 3905 dbSNP
rs1160902125 3911 dbSNP
rs144352208 3928 dbSNP
rs1023874062 3932 dbSNP
rs1188657195 3938 dbSNP
rs1425825871 3941 dbSNP
rs969624165 3956 dbSNP
rs1210332919 3960 dbSNP
rs577088372 3965 dbSNP
rs1218638461 3987 dbSNP
rs911156245 3996 dbSNP
rs1228758248 3997 dbSNP
rs1259967924 3999 dbSNP
rs1267311129 4001 dbSNP
rs879545155 4003 dbSNP
rs1326639982 4025 dbSNP
rs1205242320 4028 dbSNP
rs1413632138 4034 dbSNP
rs868233238 4039 dbSNP
rs113998750 4043 dbSNP
rs17500878 4046 dbSNP
rs1418465678 4047 dbSNP
rs1384837824 4051 dbSNP
rs1164266370 4053 dbSNP
rs1184805359 4068 dbSNP
rs956755850 4070 dbSNP
rs913056509 4071 dbSNP
rs945498792 4073 dbSNP
rs988237798 4079 dbSNP
rs1181902542 4082 dbSNP
rs184425716 4083 dbSNP
rs10026640 4090 dbSNP
rs925333384 4090 dbSNP
rs1445278839 4099 dbSNP
rs946553860 4100 dbSNP
rs140138141 4101 dbSNP
rs140766094 4113 dbSNP
rs5857637 4113 dbSNP
rs5029114 4122 dbSNP
rs1318142448 4136 dbSNP
rs1279591218 4137 dbSNP
rs1397590487 4138 dbSNP
rs1055522544 4139 dbSNP
rs1388893399 4140 dbSNP
rs188533651 4147 dbSNP
rs1412788284 4150 dbSNP
rs1164630261 4151 dbSNP
rs771897982 4156 dbSNP
rs1331034492 4159 dbSNP
rs1014252019 4170 dbSNP
rs1040028121 4172 dbSNP
rs897487785 4173 dbSNP
rs142103514 4176 dbSNP
rs1241447714 4177 dbSNP
rs1199435632 4181 dbSNP
rs1453137564 4182 dbSNP
rs13328049 4190 dbSNP
rs1212809739 4198 dbSNP
rs1348332744 4200 dbSNP
rs887550420 4205 dbSNP
rs1235184010 4206 dbSNP
rs1212311424 4212 dbSNP
rs1275024713 4218 dbSNP
rs1343914005 4219 dbSNP
rs1198197611 4220 dbSNP
rs1005688179 4223 dbSNP
rs1023775053 4224 dbSNP
rs1447961219 4227 dbSNP
rs1483658678 4228 dbSNP
rs1204998537 4229 dbSNP
rs905415610 4233 dbSNP
rs1409484265 4237 dbSNP
rs1003760492 4239 dbSNP
rs766391890 4239 dbSNP
rs1174370809 4244 dbSNP
rs1478991331 4251 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uuccucguuccgcCGUAGAGa 5'
                       ||||||| 
Target 5' ---------cuuaGCAUCUCu 3'
 		1 - 12
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_016531 | 3UTR | GGGGGAAAGGGCGAGAAAGGAUCAGAUUGAUCUGGGAUCAGCUUUGAGCCUGAGUUCAGUGAAUAGCCUCAUGGGCAUCUCAUGGAAUUGAUGCAUUUGCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_016531 | 3UTR | AGCCUCAUGGGCAUCUCAUGGAAUUGAUGCAUUUGCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_016531 | 3UTR | AUCAGAUUGAUCUGGGAUCAGCUUUGAGCCUGAGUUCAGUGAAUAGCCUCAUGGGCAUCUCAUGGAAUUGAUGCAUUUGCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_016531 | 3UTR | UGGGAUCAGCUUUGAGCCUGAGUUCAGUGAAUAGCCUCAUGGGCAUCUCAUGGAAUUGAUGCAUUUGCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_016531 | 3UTR | CUGGGAUCAGCUUUGAGCCUGAGUUCAGUGAAUAGCCUCAUGGGCAUCUCAUGGAAUUGAUGCAUUUGCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000261438.5 | 3UTR | CUUAGCAUCUCUUAAACCAUACCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
94 hsa-miR-4708-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT095681 RBM27 RNA binding motif protein 27 2 4
MIRT104033 USP42 ubiquitin specific peptidase 42 2 6
MIRT114773 CMPK1 cytidine/uridine monophosphate kinase 1 2 2
MIRT246923 CCND1 cyclin D1 2 2
MIRT392569 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT443949 LRIT3 leucine rich repeat, Ig-like and transmembrane domains 3 2 2
MIRT446695 PAPPA pappalysin 1 2 2
MIRT447383 VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 2 2
MIRT449321 FAM120AOS family with sequence similarity 120A opposite strand 2 2
MIRT449717 C1orf61 chromosome 1 open reading frame 61 2 2
MIRT449738 TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 2 2
MIRT450531 PGLS 6-phosphogluconolactonase 2 2
MIRT455650 YARS tyrosyl-tRNA synthetase 2 2
MIRT458036 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT463468 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT466677 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 4
MIRT467789 SLC2A14 solute carrier family 2 member 14 2 2
MIRT468167 SGPL1 sphingosine-1-phosphate lyase 1 2 2
MIRT468652 SECISBP2L SECIS binding protein 2 like 2 6
MIRT469380 RER1 retention in endoplasmic reticulum sorting receptor 1 2 2
MIRT470346 PPP2R5E protein phosphatase 2 regulatory subunit B'epsilon 2 2
MIRT472418 NCKAP1 NCK associated protein 1 2 2
MIRT474612 KLF3 Kruppel like factor 3 2 2
MIRT478703 CSRNP2 cysteine and serine rich nuclear protein 2 2 2
MIRT481008 BBC3 BCL2 binding component 3 2 4
MIRT483098 TFPI tissue factor pathway inhibitor 2 2
MIRT485113 SHISA6 shisa family member 6 2 2
MIRT497533 ZNF607 zinc finger protein 607 2 2
MIRT500644 TUBB2A tubulin beta 2A class IIa 2 6
MIRT500890 STRN striatin 2 4
MIRT501900 MED13 mediator complex subunit 13 2 2
MIRT506646 MAPK1 mitogen-activated protein kinase 1 2 4
MIRT512675 ENO4 enolase family member 4 2 2
MIRT516977 OR7D2 olfactory receptor family 7 subfamily D member 2 2 2
MIRT528754 RPS27 ribosomal protein S27 2 6
MIRT539670 ZBTB44 zinc finger and BTB domain containing 44 2 2
MIRT544129 PPIL1 peptidylprolyl isomerase like 1 2 2
MIRT546382 STOX2 storkhead box 2 2 4
MIRT562143 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT568713 TMEM30B transmembrane protein 30B 2 2
MIRT571029 CENPP centromere protein P 2 2
MIRT572781 ZNF277 zinc finger protein 277 2 2
MIRT573162 SLC30A9 solute carrier family 30 member 9 2 2
MIRT609126 NUDT3 nudix hydrolase 3 2 2
MIRT609284 OAS3 2'-5'-oligoadenylate synthetase 3 2 2
MIRT613430 GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 2 2
MIRT613770 TTC38 tetratricopeptide repeat domain 38 2 2
MIRT616645 LRAT lecithin retinol acyltransferase 2 4
MIRT630892 SLC25A33 solute carrier family 25 member 33 2 2
MIRT636526 FAXC failed axon connections homolog 2 4
MIRT641394 NUBPL nucleotide binding protein like 2 2
MIRT641412 SCN2B sodium voltage-gated channel beta subunit 2 2 2
MIRT642528 CERS4 ceramide synthase 4 2 2
MIRT643186 HYPK huntingtin interacting protein K 2 2
MIRT647800 FRMD8 FERM domain containing 8 2 2
MIRT652150 TRIM71 tripartite motif containing 71 2 2
MIRT652602 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT661606 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT666339 SKAP2 src kinase associated phosphoprotein 2 2 2
MIRT670414 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT671122 ZNF573 zinc finger protein 573 2 2
MIRT671155 ANKRD9 ankyrin repeat domain 9 2 2
MIRT671338 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT671869 ZNF429 zinc finger protein 429 2 2
MIRT671974 IKZF3 IKAROS family zinc finger 3 2 2
MIRT672064 KIAA0930 KIAA0930 2 2
MIRT672654 SLC25A16 solute carrier family 25 member 16 2 4
MIRT672673 GTF2H5 general transcription factor IIH subunit 5 2 2
MIRT672771 UBE2V2 ubiquitin conjugating enzyme E2 V2 2 2
MIRT672929 LRRC2 leucine rich repeat containing 2 2 2
MIRT673159 C1orf50 chromosome 1 open reading frame 50 2 2
MIRT673272 RUNDC1 RUN domain containing 1 2 2
MIRT673332 THAP1 THAP domain containing 1 2 2
MIRT673351 SLC35F6 solute carrier family 35 member F6 2 2
MIRT673667 ZNF440 zinc finger protein 440 2 2
MIRT673904 DCTN6 dynactin subunit 6 2 2
MIRT674096 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT674401 MYCBP MYC binding protein 2 2
MIRT674525 PRR23A proline rich 23A 2 2
MIRT674793 NPR1 natriuretic peptide receptor 1 2 2
MIRT674833 ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 2 2
MIRT675066 FGD6 FYVE, RhoGEF and PH domain containing 6 2 2
MIRT675080 CCR6 C-C motif chemokine receptor 6 2 2
MIRT675126 FSD2 fibronectin type III and SPRY domain containing 2 2 2
MIRT679401 IL10RB interleukin 10 receptor subunit beta 2 2
MIRT689229 RPS19 ribosomal protein S19 2 2
MIRT694008 PPIL4 peptidylprolyl isomerase like 4 2 2
MIRT699671 SFT2D2 SFT2 domain containing 2 2 2
MIRT706213 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT706548 GJD2 gap junction protein delta 2 2 2
MIRT707418 RRP7A ribosomal RNA processing 7 homolog A 2 2
MIRT710648 GLUL glutamate-ammonia ligase 2 2
MIRT719393 NPCA1 Nasopharyngeal carcinoma 1 2 2
MIRT720166 PNPO pyridoxamine 5'-phosphate oxidase 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4708-5p Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4708-5p Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4708-5p Tripterygium wilfordii Hook F sensitive tissue
hsa-miR-4708-5p Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-4708-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4708-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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