miRTarBase - #MIRT474782


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pre-miRNA Information
pre-miRNA hsa-mir-4481   
Genomic Coordinates chr10: 12653138 - 12653197
Description Homo sapiens miR-4481 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4481
Sequence 1| GGAGUGGGCUGGUGGUU |17
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1299710636 5 dbSNP
rs1433739601 12 dbSNP
rs1266754238 14 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol KIAA0895L   
Synonyms -
Description KIAA0895 like
Transcript NM_001040715   
Expression
Putative miRNA Targets on KIAA0895L
3'UTR of KIAA0895L
(miRNA target sites are highlighted)		 
>KIAA0895L|NM_001040715|3'UTR
   1 TGTCCGTTGAGGGCTGCAGTCAGAGGCCCTGGACAGAAGCTCCAGATAGGCCCCTAGAACATGAAGCAGTTTGCTCTGTG
  81 CGTCCACGGCCTAGGTGTTTCTTGGGGGTGTTGGGAGGGCAGGAGCATTCCTTGAGGAGGAGTGGCAACATCAAAGTGTT
 161 TGTGTCCCTTGCCAGCCTCCCTGGGGTCTGGGGACCTGCAGCAGCATGTCTGGCAAACTGAGTCGCCCTCCTGCCTCCAG
 241 CTCTCTGTTGAGCAGAGGGAAGGCATGGGGGCAGGAAGAGAGCTGAGCATTGATGGGGATGGGGGTGGTTTGGGAATAGA
 321 AACTTGTTCTTGCATGAGATGGCTTTGGTTGTCCCAGTACTCCAGTCTCTCCCTTCCCTTACCTGGCCCCTTGGTGCTCC
 401 TTCAGCATTTGTGCTGTCTACCTCTCACTGGGTCCTGGTGGGGGTCGGGCTCCCTTCTCCTGGGGTGATTGATGGCCTGA
 481 GCCTGGGGTCCTGGTAGTAGAGACCCAGCTGGCCTGGGGTCTGCTTTCCGACATTTTGCCTCTCTCACTGGTCATGTATT
 561 TATTCCATATTTATATGGTCTACTTCCTGTGGCTGGGAGCAGCAGCTCCTGAAGGTTCCGTGGGGGTGCGGGGGGTTGGA
 641 CAGGACACTCCTTCTTGGAAGGCACCAATTTTCCCAGCCCCACTCCCATTACACACACACACACACACACACACACACAC
 721 ACACACACACACACACACACACACACACACACACACTGATTCAGGCCTTGAGAGTCAAGCCCAAGAGCTCCCTTGGCCCT
 801 GTTCCCCACTCCCTCCACTGGCCTCTGCTGTTCCTGTCTTTGCTCACACCCTCACAGCTGCTCTCTGGCAGAGGTTGGCA
 881 TAGCCTAGGAGCAGCTGCAATTGCACCTGAGGGACAGGCCCTAGAGTTTGGTGGCCCAAGTCCTGAACCCCTCTTAGACC
 961 AGGTGAGGTGCAGAGGTGGTTGCTGCTTCCAGTTTCCCTTCAGACTTAGCTGTGTGAACCCCACTCCTATCCTTTGGCCT
1041 TAGTTTTCCCATCTGTAAAACTCAGAAACGCAGTTGGAAAGTCCTTATTCATTTAGTAAGCGAATATATTATAATATGTA
1121 TAGAGCGCCTTTTGTGTAAGTCACTGGTCAGAATCCTCACTGAGCTCCCAGTCCAGAGAGAAGCCAGACAATTAAAACAG
1201 TAATGACAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uugguGGUC-GGGUGAGg 5'
               |||| ||||||| 
Target 5' ttttcCCAGCCCCACTCc 3'
 669 - 686 152.00 -22.10
2 
miRNA  3' uugguggUCGGGUGAGg 5'
                 | ||||||| 
Target 5' tgtgtgaACCCCACTCc 3'
 1011 - 1027 142.00 -15.30
3 
miRNA  3' uugguggucGGGUGAGg 5'
                   ||||||| 
Target 5' gccctgttcCCCACTCc 3'
 796 - 812 140.00 -16.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30521463 2 COSMIC
COSN16585458 21 COSMIC
COSN30146853 36 COSMIC
COSN30491809 49 COSMIC
COSN30152545 57 COSMIC
COSN30488646 73 COSMIC
COSN30132891 111 COSMIC
COSN31592828 252 COSMIC
COSN30174088 544 COSMIC
COSN26589791 567 COSMIC
COSN16744794 755 COSMIC
COSN32055743 787 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs766484292 5 dbSNP
rs546017447 6 dbSNP
rs750162898 7 dbSNP
rs767244721 11 dbSNP
rs1317342166 14 dbSNP
rs985506928 15 dbSNP
rs1262458748 19 dbSNP
rs770059135 19 dbSNP
rs763182181 20 dbSNP
rs1382063550 22 dbSNP
rs1366686313 25 dbSNP
rs1315858893 26 dbSNP
rs1454718569 27 dbSNP
rs775620045 29 dbSNP
rs1362764569 33 dbSNP
rs534752437 34 dbSNP
rs759678850 37 dbSNP
rs1387751914 39 dbSNP
rs1326251521 40 dbSNP
rs758840318 41 dbSNP
rs1323590032 42 dbSNP
rs1284051783 45 dbSNP
rs777107121 46 dbSNP
rs750448876 47 dbSNP
rs1242269032 55 dbSNP
rs141755260 55 dbSNP
rs1432842862 56 dbSNP
rs1262648718 61 dbSNP
rs557294758 62 dbSNP
rs566154158 67 dbSNP
rs1431414735 81 dbSNP
rs765753001 82 dbSNP
rs148681386 87 dbSNP
rs1024825075 88 dbSNP
rs1402170349 100 dbSNP
rs1013325792 109 dbSNP
rs1361397563 110 dbSNP
rs1404464121 125 dbSNP
rs1212225901 140 dbSNP
rs959141363 142 dbSNP
rs1350558379 149 dbSNP
rs1234637286 162 dbSNP
rs1273423803 172 dbSNP
rs1232931675 177 dbSNP
rs574799297 183 dbSNP
rs1348993756 189 dbSNP
rs1330149934 191 dbSNP
rs55898607 194 dbSNP
rs1033339648 205 dbSNP
rs1005926909 211 dbSNP
rs1295770700 216 dbSNP
rs887444487 222 dbSNP
rs1270451459 224 dbSNP
rs372483182 225 dbSNP
rs994840539 227 dbSNP
rs1471073072 228 dbSNP
rs1158909961 231 dbSNP
rs897306426 247 dbSNP
rs535075966 248 dbSNP
rs1297548695 255 dbSNP
rs1367546938 256 dbSNP
rs566169393 263 dbSNP
rs1387362853 271 dbSNP
rs552422683 275 dbSNP
rs1334490752 280 dbSNP
rs1241684480 286 dbSNP
rs1404200389 292 dbSNP
rs1310407688 293 dbSNP
rs1359119130 296 dbSNP
rs1170628548 306 dbSNP
rs1050188890 308 dbSNP
rs1293421241 316 dbSNP
rs539187059 329 dbSNP
rs570596014 336 dbSNP
rs1465302819 344 dbSNP
rs936644454 347 dbSNP
rs1373871127 348 dbSNP
rs1248394344 351 dbSNP
rs762039718 356 dbSNP
rs1182388733 359 dbSNP
rs978004587 366 dbSNP
rs1161915027 372 dbSNP
rs1442489941 372 dbSNP
rs1476923188 376 dbSNP
rs550516638 382 dbSNP
rs1458524697 388 dbSNP
rs966633593 389 dbSNP
rs1189333951 393 dbSNP
rs1444660746 398 dbSNP
rs1332572498 413 dbSNP
rs1382511792 416 dbSNP
rs746984977 420 dbSNP
rs1277040855 422 dbSNP
rs1450823904 426 dbSNP
rs1316795549 427 dbSNP
rs1340680062 429 dbSNP
rs867099323 440 dbSNP
rs1340476804 446 dbSNP
rs1251594293 462 dbSNP
rs1249147699 465 dbSNP
rs1340799423 466 dbSNP
rs1199210967 504 dbSNP
rs1262360483 505 dbSNP
rs1220053808 507 dbSNP
rs1185181446 514 dbSNP
rs992028933 544 dbSNP
rs1315580048 545 dbSNP
rs535629900 551 dbSNP
rs1192690793 555 dbSNP
rs1371428762 565 dbSNP
rs779387652 565 dbSNP
rs532312132 572 dbSNP
rs1405988367 575 dbSNP
rs959110841 577 dbSNP
rs1339071161 580 dbSNP
rs1033392171 582 dbSNP
rs1381324453 583 dbSNP
rs1292929364 585 dbSNP
rs751840185 589 dbSNP
rs1006392011 591 dbSNP
rs951717564 592 dbSNP
rs1321303127 593 dbSNP
rs1342201774 595 dbSNP
rs866529493 596 dbSNP
rs530787471 605 dbSNP
rs1485392387 615 dbSNP
rs994412750 615 dbSNP
rs897440092 618 dbSNP
rs1478882245 619 dbSNP
rs1194459613 620 dbSNP
rs1019732153 625 dbSNP
rs1479760655 626 dbSNP
rs1179151785 627 dbSNP
rs1396941707 628 dbSNP
rs1173148620 629 dbSNP
rs1453415405 630 dbSNP
rs1464247822 632 dbSNP
rs1286828185 638 dbSNP
rs1423127568 639 dbSNP
rs1165793558 646 dbSNP
rs1301952365 647 dbSNP
rs1473783551 650 dbSNP
rs1236290514 657 dbSNP
rs184434054 668 dbSNP
rs1438793006 681 dbSNP
rs1240389963 684 dbSNP
rs1197085004 686 dbSNP
rs1315712367 689 dbSNP
rs1217570175 690 dbSNP
rs1268300504 691 dbSNP
rs1256957360 692 dbSNP
rs1489863844 692 dbSNP
rs1193432623 693 dbSNP
rs1426481922 694 dbSNP
rs1233384099 700 dbSNP
rs1157350937 713 dbSNP
rs1357835557 722 dbSNP
rs1282425622 726 dbSNP
rs1243941814 727 dbSNP
rs1162477597 730 dbSNP
rs1336184487 733 dbSNP
rs1333148439 735 dbSNP
rs1363180798 738 dbSNP
rs1444262220 741 dbSNP
rs1061385 744 dbSNP
rs1399849347 745 dbSNP
rs1326810496 747 dbSNP
rs1407214930 749 dbSNP
rs1411677404 750 dbSNP
rs1389509417 751 dbSNP
rs1163238626 752 dbSNP
rs1470811798 753 dbSNP
rs889954460 755 dbSNP
rs1162540312 757 dbSNP
rs1175947083 757 dbSNP
rs1218043194 757 dbSNP
rs1223753038 757 dbSNP
rs1223851147 757 dbSNP
rs1240435812 757 dbSNP
rs1241169064 757 dbSNP
rs1247856549 757 dbSNP
rs1278532690 757 dbSNP
rs1291229841 757 dbSNP
rs1299757563 757 dbSNP
rs1306938009 757 dbSNP
rs1354090890 757 dbSNP
rs1357461925 757 dbSNP
rs1358092080 757 dbSNP
rs1377371931 757 dbSNP
rs1440637717 757 dbSNP
rs1451644649 757 dbSNP
rs1460425745 757 dbSNP
rs1480577051 757 dbSNP
rs55651439 757 dbSNP
rs58465535 757 dbSNP
rs71145962 757 dbSNP
rs755471687 757 dbSNP
rs879080789 757 dbSNP
rs1203048708 758 dbSNP
rs1260473814 758 dbSNP
rs1458543992 758 dbSNP
rs548544571 762 dbSNP
rs1177164321 775 dbSNP
rs528479325 776 dbSNP
rs1473557147 781 dbSNP
rs568300639 784 dbSNP
rs1182033761 787 dbSNP
rs1418183721 794 dbSNP
rs559815456 798 dbSNP
rs1237254017 804 dbSNP
rs1172818107 806 dbSNP
rs1400929182 816 dbSNP
rs764298760 818 dbSNP
rs1469149189 819 dbSNP
rs1334417464 828 dbSNP
rs763135257 833 dbSNP
rs903827787 843 dbSNP
rs1284939139 845 dbSNP
rs757898302 845 dbSNP
rs1287109981 849 dbSNP
rs1212873788 852 dbSNP
rs1208681277 858 dbSNP
rs374894512 860 dbSNP
rs546252736 868 dbSNP
rs1203476333 874 dbSNP
rs1261686482 891 dbSNP
rs1354366640 894 dbSNP
rs1311288687 900 dbSNP
rs1210395154 904 dbSNP
rs1241153918 906 dbSNP
rs1042804089 907 dbSNP
rs1195188570 908 dbSNP
rs1424302102 911 dbSNP
rs1237759529 914 dbSNP
rs945269371 917 dbSNP
rs1427020543 934 dbSNP
rs1375868175 940 dbSNP
rs1414753955 942 dbSNP
rs1304491242 949 dbSNP
rs1398279764 954 dbSNP
rs1438845411 954 dbSNP
rs532516594 960 dbSNP
rs1341168487 965 dbSNP
rs917882591 967 dbSNP
rs1323004947 968 dbSNP
rs1401289738 977 dbSNP
rs117263315 978 dbSNP
rs1220166291 986 dbSNP
rs745422913 988 dbSNP
rs1439541543 1010 dbSNP
rs369448592 1015 dbSNP
rs1263306331 1017 dbSNP
rs992081463 1026 dbSNP
rs1248377419 1031 dbSNP
rs1478265910 1032 dbSNP
rs937793787 1038 dbSNP
rs569771263 1040 dbSNP
rs1407581081 1049 dbSNP
rs1191464879 1053 dbSNP
rs1418134007 1058 dbSNP
rs1160620525 1065 dbSNP
rs926462089 1069 dbSNP
rs1404407852 1083 dbSNP
rs984534970 1086 dbSNP
rs563863283 1090 dbSNP
rs1437684242 1100 dbSNP
rs775380736 1101 dbSNP
rs971737111 1102 dbSNP
rs149556040 1104 dbSNP
rs1241884414 1113 dbSNP
rs574735437 1114 dbSNP
rs778697284 1114 dbSNP
rs1358186986 1125 dbSNP
rs372985188 1126 dbSNP
rs770360904 1127 dbSNP
rs867089085 1129 dbSNP
rs1180947381 1134 dbSNP
rs1288153367 1146 dbSNP
rs1214316416 1154 dbSNP
rs530373340 1157 dbSNP
rs1180819924 1168 dbSNP
rs1381135953 1171 dbSNP
rs1424149621 1175 dbSNP
rs1161500887 1179 dbSNP
rs889920392 1187 dbSNP
rs1406480399 1190 dbSNP
rs1328699675 1194 dbSNP
rs1272361125 1195 dbSNP
rs1449464512 1198 dbSNP
rs111417515 1208 dbSNP
rs368811483 1210 dbSNP
rs375713230 1211 dbSNP
rs1381560643 1212 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uugguggucGGGUGAGg 5'
                   ||||||| 
Target 5' ------uucCCCACUCc 3'
 		1 - 11
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Cardiac Tissues
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM2202478. RNA binding protein: AGO2. Condition:S3_LV_36yo_Male_AGO2_bound_RNA HITS-CLIP data was present in GSM2202479. RNA binding protein: AGO2. Condition:S4_LV_29yo_Male_AGO2_bound_RNA HITS-CLIP data was present in GSM2202476. RNA binding protein: AGO2. Condition:S1_LV_54yo_Male_AGO2_bound_RNA HITS-CLIP data was present in GSM2202481. RNA binding protein: AGO2. Condition:S6_LV_61yo_Male_AGO2_bound_RNA ...

- Spengler RM; Zhang X; Cheng C; McLendon JM; et al., 2016, Nucleic acids research.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uugGUGGU----CGGGUgagg 5'
             |||||     ||||    
Target 5' aggCACCAAUUUUCCCAgccc 3'
 		4 - 24
Article - Spengler RM; Zhang X; Cheng C; McLendon JM; et al.
- Nucleic acids research, 2016
MicroRNAs (miRs) have emerged as key biological effectors in human health and disease. These small noncoding RNAs are incorporated into Argonaute (Ago) proteins, where they direct post-transcriptional gene silencing via base-pairing with target transcripts. Although miRs have become intriguing biological entities and attractive therapeutic targets, the translational impacts of miR research remain limited by a paucity of empirical miR targeting data, particularly in human primary tissues. Here, to improve our understanding of the diverse roles miRs play in cardiovascular function and disease, we applied high-throughput methods to globally profile miR:target interactions in human heart tissues. We deciphered Ago2:RNA interactions using crosslinking immunoprecipitation coupled with high-throughput sequencing (HITS-CLIP) to generate the first transcriptome-wide map of miR targeting events in human myocardium, detecting 4000 cardiac Ago2 binding sites across >2200 target transcripts. Our initial exploration of this interactome revealed an abundance of miR target sites in gene coding regions, including several sites pointing to new miR-29 functions in regulating cardiomyocyte calcium, growth and metabolism. Also, we uncovered several clinically-relevant interactions involving common genetic variants that alter miR targeting events in cardiomyopathy-associated genes. Overall, these data provide a critical resource for bolstering translational miR research in heart, and likely beyond.
LinkOut: [PMID: 27418678]
CLIP-seq Support 1 for dataset GSM4903825
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID14_NS
Location of target site NM_001040715 | 3UTR | AAUUUUCCCAGCCCCACUCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903830
Method / RBP HITS-CLIP / AGO
Cell line / Condition Human neurons / CTLTD_shCTL_b
Location of target site NM_001040715 | 3UTR | CUCCCUCCACUGGCCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161238
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000561621.1 | 3UTR | UUCCCCACUCCCUCCACUGGCCUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
84 hsa-miR-4481 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT100715 TJAP1 tight junction associated protein 1 2 2
MIRT183589 ZC3H11A zinc finger CCCH-type containing 11A 2 2
MIRT338033 DAZAP2 DAZ associated protein 2 2 4
MIRT395796 SPCS3 signal peptidase complex subunit 3 2 2
MIRT443947 LRIT3 leucine rich repeat, Ig-like and transmembrane domains 3 2 2
MIRT450580 HIST1H2BG histone cluster 1 H2B family member g 2 6
MIRT451617 MEIS3P1 Meis homeobox 3 pseudogene 1 2 2
MIRT452331 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT453279 EFTUD2 elongation factor Tu GTP binding domain containing 2 2 2
MIRT455212 GNL1 G protein nucleolar 1 (putative) 2 2
MIRT455470 LYPLA2 lysophospholipase II 2 2
MIRT456503 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 2 2
MIRT456687 LDB1 LIM domain binding 1 2 2
MIRT456915 DDA1 DET1 and DDB1 associated 1 2 2
MIRT457603 IDS iduronate 2-sulfatase 2 2
MIRT457848 RNASEH2B ribonuclease H2 subunit B 2 4
MIRT458455 RPRM reprimo, TP53 dependent G2 arrest mediator homolog 2 2
MIRT460179 UNK unkempt family zinc finger 2 6
MIRT461465 SLC19A3 solute carrier family 19 member 3 2 2
MIRT464739 UBE2Q1 ubiquitin conjugating enzyme E2 Q1 2 2
MIRT465279 TRIM28 tripartite motif containing 28 2 2
MIRT468450 SETD1B SET domain containing 1B 2 2
MIRT468620 SUMO1 small ubiquitin-like modifier 1 2 6
MIRT469152 RNF121 ring finger protein 121 2 2
MIRT470073 PTGES2 prostaglandin E synthase 2 2 2
MIRT470172 PSMD11 proteasome 26S subunit, non-ATPase 11 2 4
MIRT473156 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT474308 LAMC1 laminin subunit gamma 1 2 2
MIRT474782 KIAA0895L KIAA0895 like 2 2
MIRT476484 GATAD2A GATA zinc finger domain containing 2A 2 2
MIRT477613 EFNA3 ephrin A3 2 2
MIRT479525 CDCA4 cell division cycle associated 4 2 2
MIRT479973 CARD10 caspase recruitment domain family member 10 2 2
MIRT480410 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT480426 C17orf85 nuclear cap binding subunit 3 2 2
MIRT483573 SYT2 synaptotagmin 2 2 2
MIRT483664 QSOX2 quiescin sulfhydryl oxidase 2 2 4
MIRT484532 POLD3 DNA polymerase delta 3, accessory subunit 2 2
MIRT484616 SIX3 SIX homeobox 3 2 6
MIRT485897 ZFP36 ZFP36 ring finger protein 2 2
MIRT486505 MYH11 myosin heavy chain 11 2 2
MIRT487505 GRK5 G protein-coupled receptor kinase 5 2 2
MIRT488852 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT489464 MSC musculin 2 2
MIRT491170 LRP3 LDL receptor related protein 3 2 2
MIRT496627 TMEM67 transmembrane protein 67 2 2
MIRT497616 ANG angiogenin 2 2
MIRT497766 KIAA0895 KIAA0895 2 2
MIRT499680 MRE11A MRE11 homolog, double strand break repair nuclease 2 6
MIRT499774 SLC29A2 solute carrier family 29 member 2 2 2
MIRT501745 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT504995 ZNF652 zinc finger protein 652 2 2
MIRT511664 HIST1H3C histone cluster 1 H3 family member c 2 2
MIRT511690 HIST1H2BO histone cluster 1 H2B family member o 2 4
MIRT511703 HIST1H2BL histone cluster 1 H2B family member l 2 4
MIRT511734 HIST1H2BE histone cluster 1 H2B family member e 2 8
MIRT512858 TBC1D13 TBC1 domain family member 13 2 2
MIRT513444 EMP1 epithelial membrane protein 1 2 6
MIRT515681 TFPI tissue factor pathway inhibitor 2 2
MIRT523529 GLUL glutamate-ammonia ligase 2 2
MIRT525546 PHB2 prohibitin 2 2 4
MIRT526209 SNX24 sorting nexin 24 2 2
MIRT531554 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT533764 TMEM135 transmembrane protein 135 2 2
MIRT545582 SNRPA1 small nuclear ribonucleoprotein polypeptide A' 2 2
MIRT552434 ZNF460 zinc finger protein 460 2 2
MIRT561159 BCL2L12 BCL2 like 12 2 2
MIRT562345 EXOSC2 exosome component 2 2 2
MIRT570659 KDM6B lysine demethylase 6B 2 2
MIRT571076 TCHHL1 trichohyalin like 1 2 2
MIRT571330 TPCN2 two pore segment channel 2 2 2
MIRT571603 TOB2 transducer of ERBB2, 2 2 2
MIRT573013 RPP25 ribonuclease P and MRP subunit p25 2 2
MIRT609041 EP300 E1A binding protein p300 2 2
MIRT613398 DNAH17 dynein axonemal heavy chain 17 2 2
MIRT635589 TTC9C tetratricopeptide repeat domain 9C 2 2
MIRT661118 FPR1 formyl peptide receptor 1 2 2
MIRT690103 PNMA2 paraneoplastic Ma antigen 2 2 2
MIRT694972 PLAC8 placenta specific 8 2 2
MIRT695515 ALPI alkaline phosphatase, intestinal 2 2
MIRT695578 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT699570 SIT1 signaling threshold regulating transmembrane adaptor 1 2 2
MIRT701991 MIER3 MIER family member 3 2 2
MIRT725464 GRAP2 GRB2-related adaptor protein 2 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4481 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-mir-4481 Androstenedione 6128 NSC9563 sensitive cell line (MCF-7)
hsa-mir-4481 Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-4481 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4481 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (cytosolic RNA)
hsa-miR-4481 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4481 Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-4481 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-4481 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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