miRTarBase - #MIRT474897


—
pre-miRNA Information
pre-miRNA hsa-mir-4316   
Genomic Coordinates chr17: 77396984 - 77397054
Description Homo sapiens miR-4316 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4316
Sequence 11| GGUGAGGCUAGCUGGUG |27
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs989002279 5 dbSNP
rs957742923 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol KCTD21   
Synonyms KCASH2
Description potassium channel tetramerization domain containing 21
Transcript NM_001029859   
Expression
Putative miRNA Targets on KCTD21
3'UTR of KCTD21
(miRNA target sites are highlighted)		 
>KCTD21|NM_001029859|3'UTR
   1 AAGGACCCCAACAACACTGGAGATGGGGAGTCCCAGGAAGCTCATGTCAGCCAGGTCTTGGAGGGCATCTCGCCAGTGGT
  81 GCGAGGCAGGGGACTATACTAATCTGTATTAATTGTGTAGCAGGACTTGATTCCCCCCATGATGAAGTCCACCTTTTGGA
 161 ATCCAGTGTCCTCTGAACAGAACCACCTTTTTTCTTGCCATTTTGAGCTGCAGACAGGCGGTTTATTATGACAAGTGAAG
 241 AGTCAGCTGATGTGTACTAAAGGAGGCCATAGGAGGATTTTCCAGCCAGGACAAAAGAGCAGCAGTTTTCTCCTGGGCTC
 321 CATCTCTCTGTACCGCTAGCCAGTGCCGCATTTATCCATCTGTAAGAAGGCCCTGGTGGAGAGGATGGGATGAGAACAAG
 401 AGGCTACCTCCAGTTAACCAGGACATAAAGTCCCCAGCGGTTCCTGTCACACCTGCTCCTCCCTCCCCAGGGTGCATCCA
 481 TGATCGTGGATGTTTGCCCAGGGGTGACCATGTTTGGCTGGCTTGGAATGCTGTGCATTCTCAGAGCTCTGTTAGTGTCC
 561 CCTCTTGGGGGTCAGAGATGAGGTGTGGCAGGGTCTAGAGGAATGAGTGTCCAGGCAGAGTTCAGAAGGTAGGAATGTCC
 641 CTCTTGATAGGGCTGAATCAAGGGATTCCTGGCTTTAGAAAGGGTCTGCTATCTTTGCAAAAATGTGCAAGTATCTGTAG
 721 CCAGTGTAATGAAATCACTTCCAAATCCAGCCTGTTACCTGACTTTTGTCATTGTTTTCCCAAAAATTTGAGGTATCATT
 801 GAAACAGGTCATTTTAAACAAATCTATTACGGATTCTCAGGGTTGGAAATAATTCGATGATTGCTTAGTCCTCCCCCACC
 881 CCTAGAACACCCCAGCACATCTGAAGATGAGCGCCTCTCCCTGGGTACCTGCAAGTGATCACCTTGGCCTGCTTGCATAC
 961 CTTGGCTGATAGGAAGCGCGCCATCCCCAAGGCAGCTCCTGCTGTGGTTGGACAGTGCTGACTGTTAGACAGTTCTTCCC
1041 TATATTGAGCCAAAATCTGTCCTGCCACTTGCTGGATCTTGGTTGCAGACCTTCCCATTCACCCAGTTATATATCTTTGC
1121 TTTCAAAATAGTCACCTTGAGAGACCAGACATTTTTCTGAAAACATCATTACTCAGAATTCAGATTCCCCTCTGGGATCT
1201 GTCTTCAGAATCAAAGTTAGCTCTTTTCTATCCCCTGTAAGTCAGTCCCCTTTTGTTGTAGCTTCACCTCGTTTGTGACC
1281 CCCACTTCACCCACCTTCCCCACCATCTGTGGCTCCATATACCTTTCGACCATTTTCTGCTGGAAGAGGAAGATTCACGG
1361 CCCCTGAGGAGATCCAGAGGAAAGAGACGGTCTCCAAGGGTGCTGTGCAGCAAGGAGCCCAGGAGTGGTATGAACCGTAA
1441 CAGTGCCCTTAGAGTAAATGTGCGGCCCCTAAGACCCTGCCCTCAGGAAGGCGGCCTTCCCCTGCAGTCCTGTGTCCCAC
1521 CCCTGGGTCTCTGTAGGGTGCCATCCAGGGCAAGCAACCCAAGCACTGCTTCCCACCGGGTGATGAGCCATGCAGGCCTC
1601 CAAACTGCACGTCATGATTCATCCCTAAAGTGAGTTTGGCCTTGAGAGTCCCCAGGGTCCTCCCCCACTGGGCAGGGGTC
1681 CTCAAAGCCAAGGAAGCCTGGTGACACAGGCACCCATGGGAGGTGGGCCCAGAAAGGGGCTTCCCATAGATAGGCCCTGT
1761 GAGTAGGGAGCTTGTACACTGGGCCATGGGCAGCGCCAGTTCCCTTGAGCAGTAAAGGCCCTTTTCCCCCTACGGTGGGA
1841 CCCAGGAGTCTCTCTGACAGCTTTTCTGCCAGGCACAGTGGCTCATGCCTGTAATCCCAACACTCTGGGAGGCCGAGGCG
1921 GGAAGATCACTTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACGTCGTCTCTGCTAAAAATACAAAAAT
2001 TAGCTGGGTGTGGTGACAGGCGCCTATAACCCCAGCTATTTGGGAGGCTGAGGCAGTAGAATCGCTTGAACCCAGATAGC
2081 AGAGGTTGCAGTGAGCTGAGAGTGTGCCATTGCAGAGAGACTCCATCCCAAAAAAAGACAGCTGTCCCAGGCCAAGGGTA
2161 CTTGGGAGAGCCCCTCATGGAGAACCTAGTTTAGACCAAGTAGCAGAAGCTGTGGTCATAACAAAACAATTTGAGGAAGA
2241 AATCTTACAAATCACCACTGCCCTTTCTCCTTTTCCATAAAACTGTCCATCTTTTCGGTGCTCCCTAATCCAAGCAGCTT
2321 GACTTTAGAGAAGTTGCAGAAGCAGTGAAGCCACTAACATGCTGTGTGACTTTATGCAAGTCACTCACCTCACTGAGCCA
2401 CCTCCATTTCTTCATCTGTGAAATAGGCATAACAGTAATACATAACCCTACCTACCTCACAGGGCTGTTGTGAGGATCAA
2481 ATGAAATAATGTAACGTGAGAATACAGTATAAATGATAAAGGATTGTT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' guggucgAUCGGAGUGg 5'
                 ||||:|||| 
Target 5' tttgttgTAGCTTCACc 3'
 1252 - 1268 134.00 -14.50
2 
miRNA  3' guggucgaucGGAGUGg 5'
                    |||||| 
Target 5' aagtcactcaCCTCACt 3'
 2378 - 2394 120.00 -11.30
3 
miRNA  3' guggucgaucGGAGUGg 5'
                    |||||| 
Target 5' accctacctaCCTCACa 3'
 2445 - 2461 120.00 -12.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN1543545 4 COSMIC
COSN26981172 17 COSMIC
COSN30455586 27 COSMIC
COSN31512273 33 COSMIC
COSN8863614 36 COSMIC
COSN30522114 37 COSMIC
COSN30109191 42 COSMIC
COSN30123095 71 COSMIC
COSN16130527 72 COSMIC
COSN13352343 82 COSMIC
COSN8584765 86 COSMIC
COSN30110867 117 COSMIC
COSN30524030 124 COSMIC
COSN24303734 219 COSMIC
COSN27850445 607 COSMIC
COSN30166752 704 COSMIC
COSN28768188 830 COSMIC
COSN31589724 871 COSMIC
COSN7020295 968 COSMIC
COSN24656759 1085 COSMIC
COSN7020294 1346 COSMIC
COSN216965 1437 COSMIC
COSN25271332 1869 COSMIC
COSN31540991 2362 COSMIC
COSN31603634 2398 COSMIC
COSN28658421 2425 COSMIC
COSN23577190 2515 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs752867312 3 dbSNP
rs765435164 4 dbSNP
rs755490315 6 dbSNP
rs754380540 8 dbSNP
rs1387420904 10 dbSNP
rs766583173 11 dbSNP
rs761167201 13 dbSNP
rs773860364 14 dbSNP
rs972959546 17 dbSNP
rs763785078 18 dbSNP
rs1200205932 19 dbSNP
rs368809886 26 dbSNP
rs755258463 29 dbSNP
rs1431610228 30 dbSNP
rs762418147 32 dbSNP
rs867538587 33 dbSNP
rs230661 36 dbSNP
rs769308293 38 dbSNP
rs759404638 40 dbSNP
rs373870024 43 dbSNP
rs1264589562 45 dbSNP
rs761516895 47 dbSNP
rs776326346 48 dbSNP
rs1301101134 55 dbSNP
rs1364857991 57 dbSNP
rs1307673850 61 dbSNP
rs1284631121 71 dbSNP
rs576966487 72 dbSNP
rs1029861832 78 dbSNP
rs1028563876 82 dbSNP
rs553931929 83 dbSNP
rs998027602 87 dbSNP
rs147630167 92 dbSNP
rs1390269907 97 dbSNP
rs1293937673 99 dbSNP
rs1042295887 118 dbSNP
rs1417335308 123 dbSNP
rs946628229 126 dbSNP
rs1364561096 135 dbSNP
rs766493761 139 dbSNP
rs1054439737 141 dbSNP
rs1364801610 148 dbSNP
rs937367393 149 dbSNP
rs189052860 158 dbSNP
rs981971111 162 dbSNP
rs1390270583 171 dbSNP
rs1378199594 178 dbSNP
rs1158007163 188 dbSNP
rs1328989545 191 dbSNP
rs1337135623 194 dbSNP
rs1243384623 197 dbSNP
rs950203754 213 dbSNP
rs1040014683 214 dbSNP
rs554892177 219 dbSNP
rs776023118 220 dbSNP
rs538527358 221 dbSNP
rs1042249403 228 dbSNP
rs374705409 229 dbSNP
rs1444956648 232 dbSNP
rs1029375519 236 dbSNP
rs1371233496 239 dbSNP
rs772652812 257 dbSNP
rs902319501 267 dbSNP
rs1398089003 269 dbSNP
rs1485183168 270 dbSNP
rs534879786 283 dbSNP
rs184416123 290 dbSNP
rs879757591 291 dbSNP
rs1453785928 293 dbSNP
rs760657548 294 dbSNP
rs1216525272 297 dbSNP
rs1227415150 301 dbSNP
rs746384875 313 dbSNP
rs1320014092 315 dbSNP
rs1055080560 322 dbSNP
rs927973752 323 dbSNP
rs1461966463 326 dbSNP
rs937353949 329 dbSNP
rs532372828 334 dbSNP
rs117608617 335 dbSNP
rs1170978062 343 dbSNP
rs181042728 345 dbSNP
rs530165159 347 dbSNP
rs1406951839 348 dbSNP
rs1467305239 358 dbSNP
rs1358399643 360 dbSNP
rs1304948050 371 dbSNP
rs1297293665 374 dbSNP
rs1382019770 380 dbSNP
rs1420297134 383 dbSNP
rs112978408 385 dbSNP
rs541701212 398 dbSNP
rs910134381 402 dbSNP
rs986119977 409 dbSNP
rs1324517918 413 dbSNP
rs1020306829 419 dbSNP
rs997071399 421 dbSNP
rs953704415 425 dbSNP
rs1476597633 432 dbSNP
rs1259186358 435 dbSNP
rs531596707 438 dbSNP
rs965627988 439 dbSNP
rs1019036209 440 dbSNP
rs778007747 442 dbSNP
rs1198041954 443 dbSNP
rs902176845 452 dbSNP
rs1434539883 460 dbSNP
rs1216329342 463 dbSNP
rs529697922 465 dbSNP
rs1010647710 466 dbSNP
rs1362979661 468 dbSNP
rs1403696533 471 dbSNP
rs545756974 472 dbSNP
rs1054943184 479 dbSNP
rs530588 480 dbSNP
rs535504021 485 dbSNP
rs541216176 486 dbSNP
rs1216201287 487 dbSNP
rs1225600150 489 dbSNP
rs540309551 490 dbSNP
rs1221746536 491 dbSNP
rs908537161 500 dbSNP
rs1033559604 501 dbSNP
rs1002537892 504 dbSNP
rs984193464 506 dbSNP
rs905833542 508 dbSNP
rs1046128141 509 dbSNP
rs574630410 512 dbSNP
rs921445431 529 dbSNP
rs1332136721 530 dbSNP
rs1413795156 537 dbSNP
rs1402296400 543 dbSNP
rs1296563097 553 dbSNP
rs897240895 559 dbSNP
rs975520570 560 dbSNP
rs1241225863 561 dbSNP
rs966017902 578 dbSNP
rs1356924669 580 dbSNP
rs1019904954 581 dbSNP
rs1463786039 593 dbSNP
rs1453290689 600 dbSNP
rs999505681 606 dbSNP
rs966434562 609 dbSNP
rs1475959125 611 dbSNP
rs868594521 621 dbSNP
rs1020615965 627 dbSNP
rs1244155910 634 dbSNP
rs910061795 637 dbSNP
rs1049981921 641 dbSNP
rs932915953 644 dbSNP
rs867771411 646 dbSNP
rs1442293320 648 dbSNP
rs1257024428 651 dbSNP
rs1415116685 655 dbSNP
rs1010680452 668 dbSNP
rs1168405490 676 dbSNP
rs893532664 681 dbSNP
rs966399740 684 dbSNP
rs1333546339 691 dbSNP
rs1380888466 693 dbSNP
rs1451598479 697 dbSNP
rs913650866 703 dbSNP
rs17136321 704 dbSNP
rs1002080818 705 dbSNP
rs1212800767 705 dbSNP
rs1219422461 707 dbSNP
rs1200003550 712 dbSNP
rs906349225 714 dbSNP
rs1033942537 717 dbSNP
rs1260819867 719 dbSNP
rs1046336521 720 dbSNP
rs939913644 724 dbSNP
rs908567702 731 dbSNP
rs773795749 741 dbSNP
rs1048352213 751 dbSNP
rs1185221527 755 dbSNP
rs1474057836 755 dbSNP
rs1282143182 764 dbSNP
rs1447215706 765 dbSNP
rs1466166765 766 dbSNP
rs931404580 767 dbSNP
rs1338209099 770 dbSNP
rs538064594 772 dbSNP
rs1469530340 773 dbSNP
rs1334556898 779 dbSNP
rs189841855 786 dbSNP
rs1398860534 789 dbSNP
rs975901102 798 dbSNP
rs897167626 805 dbSNP
rs1422114402 807 dbSNP
rs1200744426 810 dbSNP
rs746006477 811 dbSNP
rs965608923 812 dbSNP
rs1280304434 819 dbSNP
rs1444432441 821 dbSNP
rs912708998 822 dbSNP
rs1037044391 826 dbSNP
rs977728299 828 dbSNP
rs7103718 830 dbSNP
rs538611908 831 dbSNP
rs1427361399 836 dbSNP
rs989105905 853 dbSNP
rs1480151814 854 dbSNP
rs566511233 855 dbSNP
rs1404643451 856 dbSNP
rs546637823 858 dbSNP
rs1050330942 859 dbSNP
rs1361063931 863 dbSNP
rs957687155 864 dbSNP
rs1439716084 869 dbSNP
rs1280801700 874 dbSNP
rs753323637 879 dbSNP
rs1033460947 881 dbSNP
rs1276203012 882 dbSNP
rs763793969 884 dbSNP
rs760419844 898 dbSNP
rs1222397414 899 dbSNP
rs1285820569 901 dbSNP
rs576989615 908 dbSNP
rs1025204778 912 dbSNP
rs779222802 913 dbSNP
rs1451055416 921 dbSNP
rs1199709624 923 dbSNP
rs913575656 924 dbSNP
rs1157767556 929 dbSNP
rs1380753861 932 dbSNP
rs1421294623 943 dbSNP
rs1301155436 945 dbSNP
rs1364911792 948 dbSNP
rs1004146076 950 dbSNP
rs1357014152 951 dbSNP
rs1333601922 953 dbSNP
rs536338610 955 dbSNP
rs989198977 958 dbSNP
rs1354789492 962 dbSNP
rs230662 963 dbSNP
rs548320918 966 dbSNP
rs926424957 969 dbSNP
rs767977930 970 dbSNP
rs531428355 971 dbSNP
rs562768611 972 dbSNP
rs931353932 973 dbSNP
rs552485936 977 dbSNP
rs970629321 978 dbSNP
rs1039819465 979 dbSNP
rs753941225 980 dbSNP
rs1444004125 987 dbSNP
rs1161478235 989 dbSNP
rs369908243 990 dbSNP
rs1458393244 994 dbSNP
rs944105282 995 dbSNP
rs1005533486 999 dbSNP
rs1331546359 1002 dbSNP
rs1378694129 1014 dbSNP
rs1449418700 1016 dbSNP
rs1347754969 1018 dbSNP
rs1246255219 1028 dbSNP
rs532478162 1028 dbSNP
rs1405121167 1029 dbSNP
rs1386197278 1032 dbSNP
rs1028441393 1038 dbSNP
rs560187042 1058 dbSNP
rs997420348 1060 dbSNP
rs1258911294 1064 dbSNP
rs1459292198 1083 dbSNP
rs1181506313 1086 dbSNP
rs901343602 1088 dbSNP
rs977966071 1097 dbSNP
rs1189455655 1099 dbSNP
rs184793098 1102 dbSNP
rs1371285372 1106 dbSNP
rs1438308232 1109 dbSNP
rs945622189 1110 dbSNP
rs574433787 1111 dbSNP
rs1401992131 1113 dbSNP
rs892112046 1119 dbSNP
rs1053429104 1120 dbSNP
rs560823251 1126 dbSNP
rs1471317763 1131 dbSNP
rs936386275 1155 dbSNP
rs191994039 1171 dbSNP
rs1490461216 1185 dbSNP
rs1293588911 1186 dbSNP
rs1218061539 1187 dbSNP
rs1278973058 1224 dbSNP
rs914865011 1227 dbSNP
rs575762029 1230 dbSNP
rs1307173079 1231 dbSNP
rs1483424964 1232 dbSNP
rs1201990943 1235 dbSNP
rs145317421 1241 dbSNP
rs1365113567 1247 dbSNP
rs538922904 1249 dbSNP
rs917772539 1250 dbSNP
rs971931809 1254 dbSNP
rs1436696476 1255 dbSNP
rs1466838732 1258 dbSNP
rs961919236 1259 dbSNP
rs778067804 1260 dbSNP
rs1399994167 1270 dbSNP
rs573243583 1271 dbSNP
rs984077334 1276 dbSNP
rs1221781898 1279 dbSNP
rs952782011 1281 dbSNP
rs1360441732 1282 dbSNP
rs1235111574 1284 dbSNP
rs980564628 1284 dbSNP
rs187574842 1285 dbSNP
rs1487918467 1288 dbSNP
rs1024816182 1290 dbSNP
rs1003961826 1295 dbSNP
rs996946294 1298 dbSNP
rs866639888 1299 dbSNP
rs1402499504 1305 dbSNP
rs1489610231 1305 dbSNP
rs1423090569 1306 dbSNP
rs1425394529 1324 dbSNP
rs536252690 1327 dbSNP
rs117114945 1328 dbSNP
rs1178674953 1330 dbSNP
rs527462 1340 dbSNP
rs1419490100 1349 dbSNP
rs1299286390 1353 dbSNP
rs1363033865 1354 dbSNP
rs1434353436 1354 dbSNP
rs537585897 1358 dbSNP
rs1270855741 1359 dbSNP
rs1191234261 1365 dbSNP
rs769935885 1366 dbSNP
rs1307350490 1368 dbSNP
rs1009760474 1371 dbSNP
rs892716255 1372 dbSNP
rs1261221702 1373 dbSNP
rs1217805967 1376 dbSNP
rs568938590 1388 dbSNP
rs748364410 1389 dbSNP
rs867749119 1391 dbSNP
rs899867598 1395 dbSNP
rs1040088836 1399 dbSNP
rs1175053193 1400 dbSNP
rs944151837 1402 dbSNP
rs891171543 1404 dbSNP
rs1237204524 1406 dbSNP
rs796497385 1411 dbSNP
rs184799633 1412 dbSNP
rs1159666196 1417 dbSNP
rs949181628 1418 dbSNP
rs781453420 1419 dbSNP
rs917690527 1421 dbSNP
rs758168648 1422 dbSNP
rs946229339 1424 dbSNP
rs1036141571 1426 dbSNP
rs532438336 1432 dbSNP
rs192456426 1436 dbSNP
rs117340236 1437 dbSNP
rs777206060 1439 dbSNP
rs114171467 1442 dbSNP
rs1376869539 1443 dbSNP
rs1227739701 1446 dbSNP
rs529678869 1447 dbSNP
rs1289990801 1448 dbSNP
rs561002158 1457 dbSNP
rs1322942235 1461 dbSNP
rs952787944 1463 dbSNP
rs543953901 1464 dbSNP
rs1455745371 1482 dbSNP
rs1240485546 1484 dbSNP
rs1472015814 1485 dbSNP
rs926322351 1493 dbSNP
rs1368184721 1495 dbSNP
rs1357515077 1508 dbSNP
rs921285993 1510 dbSNP
rs1168673074 1512 dbSNP
rs1399810079 1516 dbSNP
rs1470465385 1533 dbSNP
rs1431679868 1536 dbSNP
rs980810426 1540 dbSNP
rs965471334 1542 dbSNP
rs557349022 1544 dbSNP
rs1019738371 1546 dbSNP
rs1381295473 1554 dbSNP
rs970505055 1558 dbSNP
rs1277080152 1559 dbSNP
rs1318153479 1564 dbSNP
rs1200063046 1566 dbSNP
rs866376977 1574 dbSNP
rs1276079902 1575 dbSNP
rs535859275 1577 dbSNP
rs917699788 1578 dbSNP
rs575323240 1582 dbSNP
rs1238525412 1598 dbSNP
rs372399280 1610 dbSNP
rs867258963 1611 dbSNP
rs1423091446 1613 dbSNP
rs1203743721 1627 dbSNP
rs1478192922 1629 dbSNP
rs1009737742 1637 dbSNP
rs565130178 1640 dbSNP
rs1334621841 1658 dbSNP
rs1360810142 1660 dbSNP
rs767708506 1662 dbSNP
rs1026756954 1665 dbSNP
rs995404222 1666 dbSNP
rs768359966 1667 dbSNP
rs964277793 1672 dbSNP
rs1296667349 1676 dbSNP
rs904833599 1681 dbSNP
rs230663 1692 dbSNP
rs1215004426 1694 dbSNP
rs1462176413 1703 dbSNP
rs1488631944 1710 dbSNP
rs1195977597 1713 dbSNP
rs1245174854 1716 dbSNP
rs1477853971 1718 dbSNP
rs1172938201 1722 dbSNP
rs1426920974 1725 dbSNP
rs1008607567 1728 dbSNP
rs1013699157 1747 dbSNP
rs1157922253 1749 dbSNP
rs751123145 1754 dbSNP
rs1453448129 1756 dbSNP
rs1401271974 1758 dbSNP
rs1321065970 1761 dbSNP
rs573157789 1769 dbSNP
rs553276369 1778 dbSNP
rs940488605 1781 dbSNP
rs1350432898 1782 dbSNP
rs188906797 1783 dbSNP
rs1238461884 1789 dbSNP
rs1010305282 1794 dbSNP
rs148875580 1795 dbSNP
rs1206956252 1797 dbSNP
rs558572863 1806 dbSNP
rs762632024 1809 dbSNP
rs1049419888 1810 dbSNP
rs1172249876 1812 dbSNP
rs937584294 1818 dbSNP
rs1199776074 1819 dbSNP
rs1255149289 1820 dbSNP
rs557353990 1826 dbSNP
rs1380867012 1827 dbSNP
rs772702967 1832 dbSNP
rs1045977846 1833 dbSNP
rs949108170 1834 dbSNP
rs917579502 1845 dbSNP
rs1405430973 1846 dbSNP
rs1412936468 1847 dbSNP
rs931934021 1850 dbSNP
rs1308917747 1856 dbSNP
rs1378304530 1866 dbSNP
rs982520218 1868 dbSNP
rs1241897952 1870 dbSNP
rs1264192854 1891 dbSNP
rs1355795838 1900 dbSNP
rs182795465 1903 dbSNP
rs1275319470 1906 dbSNP
rs1462284542 1907 dbSNP
rs951111554 1911 dbSNP
rs230664 1915 dbSNP
rs1185402942 1917 dbSNP
rs1197640622 1919 dbSNP
rs761677713 1920 dbSNP
rs1397696643 1921 dbSNP
rs1464721703 1923 dbSNP
rs1331610922 1928 dbSNP
rs1401559340 1931 dbSNP
rs1252325735 1933 dbSNP
rs1230033503 1936 dbSNP
rs1340353371 1937 dbSNP
rs776631285 1941 dbSNP
rs190963774 1942 dbSNP
rs538839645 1944 dbSNP
rs1316300550 1956 dbSNP
rs766851552 1965 dbSNP
rs1329326842 1966 dbSNP
rs566744546 1967 dbSNP
rs1020270772 1968 dbSNP
rs1032529947 1969 dbSNP
rs980033157 1970 dbSNP
rs1456176835 1973 dbSNP
rs111770516 1975 dbSNP
rs188076042 1977 dbSNP
rs567128049 1978 dbSNP
rs1002148505 1982 dbSNP
rs1477204607 1982 dbSNP
rs1374407174 1983 dbSNP
rs748278679 1983 dbSNP
rs1046434301 1999 dbSNP
rs1301411783 2000 dbSNP
rs1402138489 2002 dbSNP
rs746802293 2003 dbSNP
rs1315348177 2005 dbSNP
rs1338594468 2007 dbSNP
rs550595488 2010 dbSNP
rs530484301 2011 dbSNP
rs887585365 2017 dbSNP
rs1046687786 2022 dbSNP
rs1048865864 2023 dbSNP
rs931834626 2026 dbSNP
rs768897708 2031 dbSNP
rs1260912764 2033 dbSNP
rs1252205858 2036 dbSNP
rs1207650927 2038 dbSNP
rs1193708194 2042 dbSNP
rs1263438806 2044 dbSNP
rs929738344 2045 dbSNP
rs1174406009 2050 dbSNP
rs796595967 2055 dbSNP
rs779756663 2058 dbSNP
rs919639740 2063 dbSNP
rs745631340 2064 dbSNP
rs1223893476 2067 dbSNP
rs1399509055 2071 dbSNP
rs1362199015 2077 dbSNP
rs900408081 2085 dbSNP
rs942555578 2090 dbSNP
rs911038761 2092 dbSNP
rs987138614 2099 dbSNP
rs1040698403 2100 dbSNP
rs955287010 2104 dbSNP
rs1300836336 2105 dbSNP
rs1312611923 2110 dbSNP
rs1236187196 2117 dbSNP
rs912582858 2119 dbSNP
rs1216724498 2132 dbSNP
rs1261903217 2137 dbSNP
rs530766779 2137 dbSNP
rs778589839 2137 dbSNP
rs112749139 2139 dbSNP
rs935385118 2142 dbSNP
rs1455010411 2146 dbSNP
rs988772156 2147 dbSNP
rs1195843657 2157 dbSNP
rs564643270 2159 dbSNP
rs957353862 2164 dbSNP
rs1033128017 2165 dbSNP
rs1336627300 2166 dbSNP
rs1353896213 2184 dbSNP
rs149688507 2187 dbSNP
rs970000934 2189 dbSNP
rs182548361 2196 dbSNP
rs992377287 2200 dbSNP
rs190355855 2201 dbSNP
rs542930746 2204 dbSNP
rs574323045 2205 dbSNP
rs1157533896 2212 dbSNP
rs1046720212 2218 dbSNP
rs1315082626 2219 dbSNP
rs1224338005 2221 dbSNP
rs1309040618 2223 dbSNP
rs1319452423 2225 dbSNP
rs749180630 2225 dbSNP
rs557069789 2227 dbSNP
rs1215954750 2229 dbSNP
rs1236654785 2230 dbSNP
rs777904818 2239 dbSNP
rs1432174841 2248 dbSNP
rs1178339128 2249 dbSNP
rs139497615 2261 dbSNP
rs752282610 2264 dbSNP
rs1422170833 2265 dbSNP
rs900343467 2270 dbSNP
rs578109207 2282 dbSNP
rs942439423 2285 dbSNP
rs1490996049 2292 dbSNP
rs911057676 2294 dbSNP
rs558305114 2296 dbSNP
rs749333815 2297 dbSNP
rs1442633639 2300 dbSNP
rs538803284 2303 dbSNP
rs1262501357 2315 dbSNP
rs935354061 2323 dbSNP
rs1227264238 2325 dbSNP
rs531061967 2326 dbSNP
rs775094606 2331 dbSNP
rs1283730997 2333 dbSNP
rs957388061 2334 dbSNP
rs979925798 2336 dbSNP
rs1032994949 2340 dbSNP
rs1457633713 2341 dbSNP
rs916747715 2342 dbSNP
rs980612387 2346 dbSNP
rs185944818 2361 dbSNP
rs970140092 2364 dbSNP
rs1482531453 2366 dbSNP
rs780939237 2373 dbSNP
rs1382643158 2385 dbSNP
rs1476220773 2389 dbSNP
rs1168862099 2392 dbSNP
rs1386506975 2393 dbSNP
rs1170287636 2394 dbSNP
rs1469034152 2400 dbSNP
rs1429520279 2406 dbSNP
rs1330581216 2407 dbSNP
rs1357368824 2410 dbSNP
rs1447111231 2416 dbSNP
rs1313400033 2421 dbSNP
rs613686 2425 dbSNP
rs751883419 2430 dbSNP
rs1397558124 2431 dbSNP
rs1481637356 2433 dbSNP
rs908161517 2456 dbSNP
rs536151254 2469 dbSNP
rs1014387876 2471 dbSNP
rs1339605579 2483 dbSNP
rs1354057213 2486 dbSNP
rs1275475515 2490 dbSNP
rs567563033 2495 dbSNP
rs181656285 2496 dbSNP
rs1258803660 2504 dbSNP
rs1486717226 2505 dbSNP
rs951839681 2506 dbSNP
rs1027374222 2513 dbSNP
rs530552719 2517 dbSNP
rs777943926 2518 dbSNP
rs766646817 2523 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' guggucgaucGGAGUGg 5'
                    |||||| 
Target 5' -cccuaccuaCCUCACa 3'
 		1 - 16
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000340067.3 | 3UTR | CCCUACCUACCUCACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
74 hsa-miR-4316 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT080624 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2 2
MIRT095088 SEC24A SEC24 homolog A, COPII coat complex component 2 4
MIRT123331 CALU calumenin 2 2
MIRT154964 RRM2 ribonucleotide reductase regulatory subunit M2 2 2
MIRT370850 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT442955 SGCD sarcoglycan delta 2 2
MIRT448240 ZNF774 zinc finger protein 774 2 2
MIRT451710 OLR1 oxidized low density lipoprotein receptor 1 2 2
MIRT452072 ATP6V0B ATPase H+ transporting V0 subunit b 2 2
MIRT455665 GLO1 glyoxalase I 2 2
MIRT460354 TXNDC16 thioredoxin domain containing 16 2 2
MIRT461908 NECAB3 N-terminal EF-hand calcium binding protein 3 2 2
MIRT462047 HOXC13 homeobox C13 2 2
MIRT462735 EFNB1 ephrin B1 2 2
MIRT463409 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT464952 TWIST1 twist family bHLH transcription factor 1 2 2
MIRT465052 TSR1 TSR1, ribosome maturation factor 2 2
MIRT467549 SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 2 4
MIRT470226 PRRC2A proline rich coiled-coil 2A 2 2
MIRT474081 LMBR1L limb development membrane protein 1 like 2 2
MIRT474481 KLHDC8B kelch domain containing 8B 2 2
MIRT474704 KIF3A kinesin family member 3A 2 2
MIRT474897 KCTD21 potassium channel tetramerization domain containing 21 2 2
MIRT475203 IL2RB interleukin 2 receptor subunit beta 2 2
MIRT477664 EFHD2 EF-hand domain family member D2 2 2
MIRT477775 E2F3 E2F transcription factor 3 2 2
MIRT477940 DPM2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory 2 2
MIRT478224 DDX52 DExD-box helicase 52 2 2
MIRT479904 CCDC117 coiled-coil domain containing 117 2 2
MIRT480639 BSCL2 BSCL2, seipin lipid droplet biogenesis associated 2 2
MIRT482435 ADM adrenomedullin 2 10
MIRT483908 GNB1L G protein subunit beta 1 like 2 2
MIRT484161 FAM71B family with sequence similarity 71 member B 2 2
MIRT484405 SNX19 sorting nexin 19 2 2
MIRT485426 LASP1 LIM and SH3 protein 1 2 2
MIRT489788 KRT80 keratin 80 2 4
MIRT490813 ASB1 ankyrin repeat and SOCS box containing 1 2 4
MIRT491176 LAMA5 laminin subunit alpha 5 2 2
MIRT491573 HSDL1 hydroxysteroid dehydrogenase like 1 2 2
MIRT492633 PLXNA1 plexin A1 2 2
MIRT492984 NAV1 neuron navigator 1 2 2
MIRT496441 RAB11FIP4 RAB11 family interacting protein 4 2 2
MIRT501829 NCOA3 nuclear receptor coactivator 3 2 2
MIRT502165 KIAA0195 transmembrane protein 94 2 2
MIRT508652 DIABLO diablo IAP-binding mitochondrial protein 2 4
MIRT509554 ACTG1 actin gamma 1 2 4
MIRT520033 YOD1 YOD1 deubiquitinase 2 6
MIRT523969 DVL3 dishevelled segment polarity protein 3 2 2
MIRT526150 KIAA1456 KIAA1456 2 2
MIRT530330 ARHGAP1 Rho GTPase activating protein 1 2 2
MIRT539985 SLC24A4 solute carrier family 24 member 4 2 4
MIRT540851 NUP155 nucleoporin 155 2 2
MIRT542326 LIMD1 LIM domains containing 1 2 2
MIRT558908 CBX5 chromobox 5 2 2
MIRT563663 SMC4 structural maintenance of chromosomes 4 2 2
MIRT565433 SURF4 surfeit 4 2 2
MIRT567773 DGAT2 diacylglycerol O-acyltransferase 2 2 2
MIRT615573 NCS1 neuronal calcium sensor 1 2 2
MIRT627336 TTLL7 tubulin tyrosine ligase like 7 2 2
MIRT632965 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT634307 SNTN sentan, cilia apical structure protein 2 2
MIRT641569 RAX retina and anterior neural fold homeobox 2 2
MIRT660509 ARL5A ADP ribosylation factor like GTPase 5A 2 2
MIRT662703 C10orf111 chromosome 10 open reading frame 111 2 4
MIRT663214 ZNF277 zinc finger protein 277 2 2
MIRT665318 YIPF4 Yip1 domain family member 4 2 2
MIRT695264 CD209 CD209 molecule 2 2
MIRT696231 LIN9 lin-9 DREAM MuvB core complex component 2 2
MIRT698867 SRPR SRP receptor alpha subunit 2 2
MIRT702700 IPO9 importin 9 2 2
MIRT704236 DHDDS dehydrodolichyl diphosphate synthase subunit 2 2
MIRT704935 CCDC120 coiled-coil domain containing 120 2 2
MIRT724285 KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 2 2
MIRT735579 VEGFA vascular endothelial growth factor A 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4316 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-miR-4316 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4316 Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

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