miRTarBase - #MIRT475798


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pre-miRNA Information
pre-miRNA hsa-mir-3170   
Genomic Coordinates chr13: 98208524 - 98208600
Description Homo sapiens miR-3170 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3170
Sequence 10| CUGGGGUUCUGAGACAGACAGU |31
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1393550535 3 dbSNP
rs1477436820 6 dbSNP
rs1291786017 11 dbSNP
rs528268116 15 dbSNP
rs1425176334 18 dbSNP
rs1351740752 19 dbSNP
rs1465654929 19 dbSNP
rs147240207 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol HDGF   
Synonyms HMG1L2
Description heparin binding growth factor
Transcript NM_001126050   
Other Transcripts NM_001126051 , NM_004494   
Expression
Putative miRNA Targets on HDGF
3'UTR of HDGF
(miRNA target sites are highlighted)		 
>HDGF|NM_001126050|3'UTR
   1 CCACCAATGTTTCAAGAGGAGCCCCCACCCTGTTCCTGCTGCTGTCTGGGTGCTACTGGGGAAACTGGCCATGGCCTGCA
  81 AACTGGGAACCCCTTTCCCACCCCAACCTGCTCTCCTCTTCTACTCACTTTTCCCACTCCAAGCCCAGCCCATGGAGATT
 161 GACCTGGATGGGGCAGGCCACCTGGCTCTCACCTCTAGGTCCCCATACTCCTATGATCTGAGTCAGAGCCATGTCTTCTC
 241 CCTGGAATGAGTTGAGGCCACTGTGTTCCTTCCGCTTGGAGCTATTTTCCAGGCTTCTGCTGGGGCCTGGGACAACTGCT
 321 CCCACCTCCTGACACCCTTCTCCCACTCTCCTAGGCATTCTGGACCTCTGGGTTGGGATCAGGGGTAGGAATGGAAAGGA
 401 TGGAGCATCAACAGCAGGGTGGGCTTGTGGGGCCTGGGAGGGGCAATCCTCAAATGCGGGGTGGGGGCAGCACAGGAGGG
 481 CGGCCTCCTTCTGAGCTCCTGTCCCCTGCTACACCTATTATCCCAGCTGCCTAGATTCAGGGAAAGTGGGACAGCTTGTA
 561 GGGGAGGGGCTCCTTTCCATAAATCCTTGATGATTGACAACACCCATTTTTCCTTTTGCCGACCCCAAGAGTTTTGGGAG
 641 TTGTAGTTAATCATCAAGAGAATTTGGGGCTTCCAAGTTGTTCGGGCCAAGGACCTGAGACCTGAAGGGTTGACTTTACC
 721 CATTTGGGTGGGAGTGTTGAGCATCTGTCCCCCTTTAGATCTCTGAAGCCACAAATAGGATGCTTGGGAAGACTCCTAGC
 801 TGTCCTTTTTCCTCTCCACACAGTGCTCAAGGCCAGCTTATAGTCATATATATCACCCAGACATAAAGGAAAAGACACAT
 881 TTTTTAGGAAATGTTTTTAATAAAAGAAAATTACAAAAAAAAATTTTAAAGACCCCTAACCCTTTGTGTGCTCTCCATTC
 961 TGCTCCTTCCCCATCGTTGCCCCCATTTCTGAGGTGCACTGGGAGGCTCCCCTTCTATTTGGGGCTTGATGACTTTCTTT
1041 TTGTAGCTGGGGCTTTGATGTTCCTTCCAGTGTCATTTCTCATCCACATACCCTGACCTGGCCCCCTCAGTGTTGTCACC
1121 AGATCTGATTTGTAACCCACTGAGAGGACAGAGAGAAATAAGTGCCCTCTCCCACCCTCTTCCTACTGGTCTCTCTATGC
1201 CTCTCTACAGTCTCGTCTCTTTTACCCTGGCCCCTCTCCCTTGGGCTCTGATGAAAAATTGCTGACTGTAGCTTTGGAAG
1281 TTTAGCTCTGAGAACCGTAGATGATTTCAGTTCTAGGAAAATAAAACCCGTTGATTACTATAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ugaCAGAC---AGAGUCUUGGGGuc 5'
             | |||    || :|||||||  
Target 5' atgGCCTGCAAACTGGGAACCCCtt 3'
 71 - 95 135.00 -16.90
2 
miRNA  3' ugACAGACAGAGUCUUGGGGUc 5'
            | ||  |:|   :|||||| 
Target 5' ttTTTCCTTTTGCCGACCCCAa 3'
 607 - 628 132.00 -9.70
3 
miRNA  3' ugacagACAGAGU----CUUGGGGuc 5'
                |||:|||    ||:||||  
Target 5' caccaaTGTTTCAAGAGGAGCCCCca 3'
 2 - 27 126.00 -16.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30515293 7 COSMIC
COSN20048132 13 COSMIC
COSN30522638 17 COSMIC
COSN31497739 19 COSMIC
COSN26957679 27 COSMIC
COSN28846451 46 COSMIC
COSN31560070 52 COSMIC
COSN30504382 53 COSMIC
COSN20048131 56 COSMIC
COSN30515830 74 COSMIC
COSN31498013 86 COSMIC
COSN20048130 97 COSMIC
COSN20048129 102 COSMIC
COSN30698706 129 COSMIC
COSN30448034 133 COSMIC
COSN20048128 145 COSMIC
COSN20048127 151 COSMIC
COSN32064393 190 COSMIC
COSN1090220 221 COSMIC
COSN30513454 223 COSMIC
COSN20048126 240 COSMIC
COSN19751296 274 COSMIC
COSN31604573 275 COSMIC
COSN31590958 279 COSMIC
COSN20048125 297 COSMIC
COSN20048124 319 COSMIC
COSN20048122 340 COSMIC
COSN20048121 366 COSMIC
COSN21181678 368 COSMIC
COSN20048120 471 COSMIC
COSN16131710 481 COSMIC
COSN21077464 490 COSMIC
COSN20048119 491 COSMIC
COSN30655904 494 COSMIC
COSN22708405 592 COSMIC
COSN31608710 616 COSMIC
COSN20052292 629 COSMIC
COSN31564827 683 COSMIC
COSN16128463 699 COSMIC
COSN32063501 727 COSMIC
COSN26660939 825 COSMIC
COSN4744091 849 COSMIC
COSN30161775 873 COSMIC
COSN31661798 880 COSMIC
COSN20095450 914 COSMIC
COSN31523184 985 COSMIC
COSN31548360 989 COSMIC
COSN31589224 997 COSMIC
COSN1407568 1048 COSMIC
COSN22445060 1127 COSMIC
COSN21373532 1227 COSMIC
COSN26554725 1295 COSMIC
COSN32082890 1317 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs765803425 2 dbSNP
rs1489004484 5 dbSNP
rs11556973 7 dbSNP
rs896281935 8 dbSNP
rs753925386 23 dbSNP
rs764091839 28 dbSNP
rs1014697471 29 dbSNP
rs1477272522 32 dbSNP
rs1259311323 36 dbSNP
rs1416492412 37 dbSNP
rs760950183 40 dbSNP
rs1488527601 41 dbSNP
rs1266474668 44 dbSNP
rs1005001875 51 dbSNP
rs566825660 75 dbSNP
rs1369246614 107 dbSNP
rs887454019 117 dbSNP
rs1452704416 120 dbSNP
rs1288547436 121 dbSNP
rs1338648843 123 dbSNP
rs1278963223 126 dbSNP
rs1402057938 126 dbSNP
rs1048709381 140 dbSNP
rs1227165592 147 dbSNP
rs761518823 152 dbSNP
rs144243169 159 dbSNP
rs1215468134 174 dbSNP
rs1354550131 179 dbSNP
rs1283466787 180 dbSNP
rs11556977 184 dbSNP
rs1468654460 187 dbSNP
rs1406039162 188 dbSNP
rs1040328912 191 dbSNP
rs1183536376 193 dbSNP
rs1414395122 195 dbSNP
rs1481653579 202 dbSNP
rs1418309598 205 dbSNP
rs1362189770 213 dbSNP
rs1406048282 220 dbSNP
rs1421826051 223 dbSNP
rs539607564 224 dbSNP
rs1176905460 229 dbSNP
rs568589896 234 dbSNP
rs550698416 238 dbSNP
rs532200506 240 dbSNP
rs935406720 243 dbSNP
rs1223694313 244 dbSNP
rs768366521 251 dbSNP
rs1262475228 267 dbSNP
rs1240493756 269 dbSNP
rs979409695 271 dbSNP
rs781196137 273 dbSNP
rs749563787 274 dbSNP
rs1359019118 276 dbSNP
rs992464618 277 dbSNP
rs1176696925 292 dbSNP
rs565052677 293 dbSNP
rs1382003508 297 dbSNP
rs1440015704 311 dbSNP
rs1159480053 321 dbSNP
rs540058701 329 dbSNP
rs116207813 332 dbSNP
rs1412856058 348 dbSNP
rs1336298303 351 dbSNP
rs1359780705 356 dbSNP
rs1015139286 358 dbSNP
rs1373635234 360 dbSNP
rs1004673046 366 dbSNP
rs369723450 368 dbSNP
rs866153960 370 dbSNP
rs577504203 371 dbSNP
rs1241240938 386 dbSNP
rs1273904177 387 dbSNP
rs1027303633 399 dbSNP
rs561181123 401 dbSNP
rs1382671187 408 dbSNP
rs1278798632 417 dbSNP
rs1306402252 423 dbSNP
rs995809224 425 dbSNP
rs1338028707 436 dbSNP
rs900153718 456 dbSNP
rs1411982740 457 dbSNP
rs1039957984 458 dbSNP
rs1477185295 460 dbSNP
rs1174528316 461 dbSNP
rs73002713 468 dbSNP
rs1465113483 481 dbSNP
rs574912091 481 dbSNP
rs1401449631 482 dbSNP
rs1329710018 490 dbSNP
rs556376794 490 dbSNP
rs534268126 495 dbSNP
rs1275016711 498 dbSNP
rs1339282012 501 dbSNP
rs1259939914 503 dbSNP
rs1181796469 505 dbSNP
rs1212956130 506 dbSNP
rs1287549090 508 dbSNP
rs1444136774 510 dbSNP
rs1188367772 512 dbSNP
rs544732053 515 dbSNP
rs577276057 517 dbSNP
rs550444571 518 dbSNP
rs1242438081 529 dbSNP
rs1247438982 537 dbSNP
rs1184056621 540 dbSNP
rs199960326 552 dbSNP
rs1425833744 565 dbSNP
rs781239733 576 dbSNP
rs1466667792 582 dbSNP
rs1163178943 597 dbSNP
rs1258686000 607 dbSNP
rs925345802 616 dbSNP
rs757395551 620 dbSNP
rs1339389645 621 dbSNP
rs1397722094 634 dbSNP
rs1279586293 641 dbSNP
rs1340591445 646 dbSNP
rs1244044001 650 dbSNP
rs1282293146 652 dbSNP
rs1243392157 655 dbSNP
rs1287783718 656 dbSNP
rs35554110 661 dbSNP
rs751664551 666 dbSNP
rs1285020601 674 dbSNP
rs1488110706 675 dbSNP
rs777801928 676 dbSNP
rs377077660 683 dbSNP
rs1367196537 684 dbSNP
rs916531893 686 dbSNP
rs1315140795 688 dbSNP
rs1360252195 691 dbSNP
rs1398242978 710 dbSNP
rs1360513948 711 dbSNP
rs1299636854 714 dbSNP
rs992099180 717 dbSNP
rs960902850 729 dbSNP
rs907722145 732 dbSNP
rs1342139111 743 dbSNP
rs11556978 744 dbSNP
rs1308350481 747 dbSNP
rs1431980467 751 dbSNP
rs1351220444 762 dbSNP
rs1238269932 770 dbSNP
rs1288345556 789 dbSNP
rs1486253605 796 dbSNP
rs1199896242 802 dbSNP
rs1254141313 804 dbSNP
rs1444673071 819 dbSNP
rs1380137482 826 dbSNP
rs1438153311 827 dbSNP
rs1362667180 832 dbSNP
rs1380484651 835 dbSNP
rs138665143 836 dbSNP
rs1465125772 841 dbSNP
rs1300612693 845 dbSNP
rs758670127 847 dbSNP
rs1403719359 848 dbSNP
rs1396598659 856 dbSNP
rs1330530682 886 dbSNP
rs951851794 891 dbSNP
rs1161963660 892 dbSNP
rs548570568 900 dbSNP
rs1311770440 903 dbSNP
rs1424091745 906 dbSNP
rs1027376790 910 dbSNP
rs1385881587 911 dbSNP
rs1165575683 912 dbSNP
rs1238029198 914 dbSNP
rs1425444752 916 dbSNP
rs1259623497 922 dbSNP
rs1185695726 923 dbSNP
rs1207135523 924 dbSNP
rs1251657014 924 dbSNP
rs201760421 924 dbSNP
rs60294423 924 dbSNP
rs1173506409 926 dbSNP
rs1378879017 928 dbSNP
rs1486107478 930 dbSNP
rs995841930 934 dbSNP
rs1467101650 940 dbSNP
rs1331839874 941 dbSNP
rs566809290 942 dbSNP
rs1386479705 948 dbSNP
rs1358299414 962 dbSNP
rs1291805034 971 dbSNP
rs1224153128 973 dbSNP
rs554872714 1001 dbSNP
rs1019018275 1009 dbSNP
rs1258000233 1012 dbSNP
rs1008519908 1017 dbSNP
rs1201071443 1023 dbSNP
rs777212858 1028 dbSNP
rs891354493 1032 dbSNP
rs7801 1037 dbSNP
rs9842 1038 dbSNP
rs1306234336 1039 dbSNP
rs1189107766 1041 dbSNP
rs1268972628 1044 dbSNP
rs1480491399 1048 dbSNP
rs1192363500 1049 dbSNP
rs999707875 1060 dbSNP
rs1215509273 1063 dbSNP
rs1467179358 1065 dbSNP
rs1171041862 1067 dbSNP
rs1342849486 1073 dbSNP
rs753587756 1088 dbSNP
rs1292030481 1091 dbSNP
rs1301696272 1105 dbSNP
rs1405753477 1119 dbSNP
rs1277689126 1121 dbSNP
rs904000907 1127 dbSNP
rs568877526 1130 dbSNP
rs144777532 1134 dbSNP
rs189681903 1137 dbSNP
rs1219762679 1138 dbSNP
rs756107317 1143 dbSNP
rs1267584004 1147 dbSNP
rs1490423527 1151 dbSNP
rs916622866 1155 dbSNP
rs1260485529 1175 dbSNP
rs865806287 1176 dbSNP
rs1187042413 1186 dbSNP
rs1412922633 1194 dbSNP
rs142515861 1195 dbSNP
rs1166714308 1197 dbSNP
rs1803706 1199 dbSNP
rs1385597802 1201 dbSNP
rs1425601590 1202 dbSNP
rs1297760650 1203 dbSNP
rs546738586 1205 dbSNP
rs528327523 1206 dbSNP
rs1401878930 1207 dbSNP
rs1289995712 1208 dbSNP
rs1379147373 1213 dbSNP
rs561142350 1214 dbSNP
rs1227076417 1215 dbSNP
rs1360598124 1217 dbSNP
rs907795514 1224 dbSNP
rs1489000231 1226 dbSNP
rs767562522 1233 dbSNP
rs1236361294 1249 dbSNP
rs951884003 1260 dbSNP
rs1183520620 1268 dbSNP
rs1243545068 1270 dbSNP
rs920393890 1272 dbSNP
rs1803707 1277 dbSNP
rs974497936 1283 dbSNP
rs1425426507 1284 dbSNP
rs1159979251 1285 dbSNP
rs964427211 1286 dbSNP
rs372144755 1296 dbSNP
rs1008967329 1303 dbSNP
rs1490071715 1315 dbSNP
rs1306660319 1316 dbSNP
rs1355468541 1318 dbSNP
rs761167868 1320 dbSNP
rs955705784 1330 dbSNP
rs113461500 1331 dbSNP
rs1309876460 1334 dbSNP
rs369139530 1338 dbSNP
rs1212157746 1340 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ugacaGACAGAGUCUUGGGGUc 5'
               || || |   |||||| 
Target 5' aacccCUUUCCC---ACCCCAa 3'
 		1 - 19
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177618. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_3_8 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ugacagacagagucuUGGGGUc 5'
                         |||||| 
Target 5' ---------uuucccACCCCAa 3'
 		1 - 13
Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000357325.5 | 3UTR | AACCCCUUUCCCACCCCAACCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
KICH 0.757 0 0.721 0 23 Click to see details
BRCA 0.439 0 0.406 0 69 Click to see details
LIHC 0.445 0 0.345 0.01 48 Click to see details
STAD 0.545 0.02 0.257 0.18 15 Click to see details
ESCA 0.771 0.02 0.679 0.05 7 Click to see details
THCA -0.199 0.07 -0.113 0.2 59 Click to see details
PRAD 0.254 0.15 0.267 0.14 18 Click to see details
BLCA -0.329 0.21 -0.190 0.33 8 Click to see details
KIRC -0.062 0.31 -0.024 0.42 67 Click to see details
LUSC 0.085 0.32 0.136 0.23 31 Click to see details
HNSC 0.092 0.35 0.113 0.31 21 Click to see details
CHOL 0.112 0.4 0.071 0.43 8 Click to see details
UCEC 0.016 0.47 0.077 0.38 18 Click to see details
KIRP 0.003 0.49 -0.080 0.33 32 Click to see details
KIRP 0.003 0.49 -0.080 0.33 32 Click to see details
KIRP 0.003 0.49 -0.080 0.33 32 Click to see details
KIRP 0.003 0.49 -0.080 0.33 32 Click to see details
KIRP 0.003 0.49 -0.080 0.33 32 Click to see details
121 hsa-miR-3170 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT074402 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT114937 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT248326 HOXC8 homeobox C8 2 2
MIRT329432 C5ORF51 chromosome 5 open reading frame 51 2 2
MIRT460868 UBE2S ubiquitin conjugating enzyme E2 S 2 2
MIRT464626 UBE4A ubiquitination factor E4A 2 2
MIRT466225 TMED10 transmembrane p24 trafficking protein 10 2 2
MIRT473424 MDM4 MDM4, p53 regulator 2 2
MIRT473514 MAX MYC associated factor X 2 2
MIRT475798 HDGF heparin binding growth factor 2 2
MIRT478032 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT482963 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT485905 PGPEP1 pyroglutamyl-peptidase I 2 6
MIRT488146 PRRC2B proline rich coiled-coil 2B 2 4
MIRT491777 ZNF24 zinc finger protein 24 2 2
MIRT493023 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT502199 HSPB8 heat shock protein family B (small) member 8 2 2
MIRT505367 TMEM154 transmembrane protein 154 2 4
MIRT505919 RCAN3 RCAN family member 3 2 4
MIRT509089 SYNPO2L synaptopodin 2 like 2 4
MIRT509103 BMP8B bone morphogenetic protein 8b 2 6
MIRT509571 HIST2H2AB histone cluster 2 H2A family member b 2 4
MIRT509782 CHAF1B chromatin assembly factor 1 subunit B 2 4
MIRT511295 KIAA1551 KIAA1551 2 2
MIRT514289 FXYD5 FXYD domain containing ion transport regulator 5 2 6
MIRT514389 CLUAP1 clusterin associated protein 1 2 2
MIRT514404 RSL1D1 ribosomal L1 domain containing 1 2 2
MIRT514421 SLC38A7 solute carrier family 38 member 7 2 2
MIRT514546 PTGR2 prostaglandin reductase 2 2 2
MIRT514790 SLC25A45 solute carrier family 25 member 45 2 2
MIRT514836 LYRM7 LYR motif containing 7 2 2
MIRT514850 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 2
MIRT515112 LMOD3 leiomodin 3 2 2
MIRT515338 CXorf36 chromosome X open reading frame 36 2 2
MIRT515582 FBXL13 F-box and leucine rich repeat protein 13 2 4
MIRT515612 ISY1 ISY1 splicing factor homolog 2 2
MIRT516018 A1CF APOBEC1 complementation factor 2 2
MIRT516721 MYPN myopalladin 2 2
MIRT516739 GSTK1 glutathione S-transferase kappa 1 2 2
MIRT516774 PTRF caveolae associated protein 1 2 4
MIRT517076 C3orf62 chromosome 3 open reading frame 62 2 2
MIRT517115 NDUFV3 NADH:ubiquinone oxidoreductase subunit V3 2 2
MIRT517196 OTUD6A OTU deubiquitinase 6A 2 2
MIRT517321 ZNF347 zinc finger protein 347 2 2
MIRT517612 DEGS1 delta 4-desaturase, sphingolipid 1 2 2
MIRT517626 ZNF491 zinc finger protein 491 2 2
MIRT517656 TRIM72 tripartite motif containing 72 2 4
MIRT517742 DIS3L DIS3 like exosome 3'-5' exoribonuclease 2 4
MIRT518002 RPL4 ribosomal protein L4 2 4
MIRT518165 FGB fibrinogen beta chain 2 2
MIRT518180 SLC27A4 solute carrier family 27 member 4 2 2
MIRT518555 GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 2 2
MIRT518572 ATP8B1 ATPase phospholipid transporting 8B1 2 2
MIRT519008 NOA1 nitric oxide associated 1 2 2
MIRT519340 CACNG1 calcium voltage-gated channel auxiliary subunit gamma 1 2 2
MIRT519363 RBM28 RNA binding motif protein 28 2 2
MIRT519388 DNASE2 deoxyribonuclease 2, lysosomal 2 4
MIRT519404 KCNA7 potassium voltage-gated channel subfamily A member 7 2 4
MIRT519615 ZNF788 zinc finger family member 788 2 4
MIRT519817 ZKSCAN4 zinc finger with KRAB and SCAN domains 4 2 2
MIRT520455 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT520761 TCF23 transcription factor 23 2 2
MIRT520981 SOCS5 suppressor of cytokine signaling 5 2 2
MIRT521275 RTF1 RTF1 homolog, Paf1/RNA polymerase II complex component 2 2
MIRT521397 RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 2 2
MIRT522023 PAQR3 progestin and adipoQ receptor family member 3 2 4
MIRT522105 NUDT3 nudix hydrolase 3 2 2
MIRT522145 NR2F6 nuclear receptor subfamily 2 group F member 6 2 4
MIRT522219 NPFFR1 neuropeptide FF receptor 1 2 2
MIRT522274 NKAP NFKB activating protein 2 2
MIRT522639 MANEAL mannosidase endo-alpha like 2 2
MIRT523167 HIST3H3 histone cluster 3 H3 2 2
MIRT523497 GMPS guanine monophosphate synthase 2 4
MIRT524033 DNAJC8 DnaJ heat shock protein family (Hsp40) member C8 2 2
MIRT524396 COQ10B coenzyme Q10B 2 2
MIRT524682 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT525542 PHB2 prohibitin 2 2 4
MIRT528430 COL9A2 collagen type IX alpha 2 chain 2 2
MIRT528738 RAB13 RAB13, member RAS oncogene family 2 2
MIRT530944 CMBL carboxymethylenebutenolidase homolog 2 2
MIRT531653 ZFP14 ZFP14 zinc finger protein 2 2
MIRT531851 MAP2K2 mitogen-activated protein kinase kinase 2 2 2
MIRT533473 TRIM71 tripartite motif containing 71 2 2
MIRT533658 TMF1 TATA element modulatory factor 1 2 2
MIRT540966 ZNF8 zinc finger protein 8 2 2
MIRT541988 MYO1C myosin IC 2 2
MIRT549545 CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit 2 2
MIRT551722 PCYT1A phosphate cytidylyltransferase 1, choline, alpha 2 2
MIRT553984 SRPR SRP receptor alpha subunit 2 2
MIRT555113 PUM2 pumilio RNA binding family member 2 2 2
MIRT563172 ZRANB3 zinc finger RANBP2-type containing 3 2 2
MIRT564006 UGT2B4 UDP glucuronosyltransferase family 2 member B4 2 2
MIRT564445 SLC35E2 solute carrier family 35 member E2 2 2
MIRT565959 RPP14 ribonuclease P/MRP subunit p14 2 2
MIRT607541 GLI2 GLI family zinc finger 2 2 2
MIRT607685 MAPK10 mitogen-activated protein kinase 10 2 2
MIRT609323 ZNF701 zinc finger protein 701 2 2
MIRT614038 THBS2 thrombospondin 2 2 2
MIRT616763 ANKRD33B ankyrin repeat domain 33B 2 2
MIRT619706 C6orf132 chromosome 6 open reading frame 132 2 2
MIRT619955 CLN8 CLN8, transmembrane ER and ERGIC protein 2 2
MIRT625229 C6orf89 chromosome 6 open reading frame 89 2 2
MIRT634238 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT634964 C8orf17 chromosome 8 open reading frame 17 2 2
MIRT639615 FGF19 fibroblast growth factor 19 2 2
MIRT642692 ZNF878 zinc finger protein 878 2 2
MIRT643689 KIAA0586 KIAA0586 2 2
MIRT645271 SLC38A5 solute carrier family 38 member 5 2 2
MIRT647340 RPH3AL rabphilin 3A like (without C2 domains) 2 2
MIRT648167 TMEM192 transmembrane protein 192 2 2
MIRT655464 PAK3 p21 (RAC1) activated kinase 3 2 2
MIRT660232 BMP7 bone morphogenetic protein 7 2 2
MIRT666181 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 2
MIRT673638 CYCS cytochrome c, somatic 2 2
MIRT674044 ATXN3 ataxin 3 2 2
MIRT691167 APOL6 apolipoprotein L6 2 2
MIRT711724 NUPL2 nucleoporin like 2 2 2
MIRT712404 MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 2 2
MIRT715537 FTCD formimidoyltransferase cyclodeaminase 2 2
MIRT715939 NUP93 nucleoporin 93 2 2
MIRT722976 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3170 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-3170 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-3170 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-3170 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3170 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-3170 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3170 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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