pre-miRNA Information
pre-miRNA hsa-mir-3915   
Genomic Coordinates chrX: 32583656 - 32583752
Description Homo sapiens miR-3915 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3915
Sequence 21| UUGAGGAAAAGAUGGUCUUAUU |42
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs997323565 10 dbSNP
rs1192161547 15 dbSNP
rs1255075246 19 dbSNP
rs1452812574 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol GRB2   
Synonyms ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2
Description growth factor receptor bound protein 2
Transcript NM_002086   
Other Transcripts NM_203506   
Expression
Putative miRNA Targets on GRB2
3'UTR of GRB2
(miRNA target sites are highlighted)
>GRB2|NM_002086|3'UTR
   1 GAGTCAAGAAGCAATTATTTAAAGAAAGTGAAAAATGTAAAACACATACAAAAGAATTAAACCCACAAGCTGCCTCTGAC
  81 AGCAGCCTGTGAGGGAGTGCAGAACACCTGGCCGGGTCACCCTGTGACCCTCTCACTTTGGTTGGAACTTTAGGGGGTGG
 161 GAGGGGGCGTTGGATTTAAAAATGCCAAAACTTACCTATAAATTAAGAAGAGTTTTTATTACAAATTTTCACTGCTGCTC
 241 CTCTTTCCCCTCCTTTGTCTTTTTTTTCATCCTTTTTTCTCTTCTGTCCATCAGTGCATGACGTTTAAGGCCACGTATAG
 321 TCCTAGCTGACGCCAATAATAAAAAACAAGAAACCAAGTGGGCTGGTATTCTCTCTATGCAAAATGTCTGTTTTAGTTGG
 401 AATGACTGAAAGAAGAACAGCTGTTCCTGTGTTCTTCGTATATACACACAAAAAGGAGCGGGCAGGGCCGCTCGATGCCT
 481 TTGCTGTTTAGCTTCCTCCAGAGGAGGGGACTTGTAGGAATCTGCCTTCCAGCCCAGACCCCCAGTGTATTTTGTCCAAG
 561 TTCACAGTAGAGTAGGGTAGAAGGAAAGCATGTCTCTGCTTCCATGGCTTCCTGAGAAAGCCCACCTGGGCTGGGCGCGG
 641 TGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCGGATCACAAGGTCAGGAGTTCGAGACCAACCTAGC
 721 CAACATGGTGAAACCCCGTCTCTACTAAAAATAAGAAATTAGCCGGGTGTGGCACGCACCTGTAGTCCCAGCTACTTGGG
 801 AGCCTGAGGCAGGAGAATCGCTTGAACCTGGGAAGTGGAGGTTGAGTGAGCCGGGACCGTGCCATTGTACTCCAGCCTGG
 881 GTGACAGAGCGAGATTCCGTCTCAAAAAAAAAAAAAAAAAGCCCACCTGAAAGCCTGTCTCTTTCCACTTTGTTGGCCCT
 961 TCCAGTGGGATTATCGAGCATGTTGTTTTTTCATAGTGCCTTTTTCCTTATTTCAAGGGTTGCTTCTGAGTGGTGTTTTT
1041 TTTTTTTTTTTAATTTGTTTTGTTTTAAAATAAGTTAAAGGCAGTCCAGAGCTTTTCAGCCAATTTGTCTCCTACTCTGT
1121 GTAAATATTTTTCCCTCCGGGCAGGGGAGCCAGGGTAGAGCAAAGGAGACAAAGCAGGAGTGGAAGGTGAGGCGTTCTCC
1201 TGCTTGTACTAAGCCAGGAGGCTTTAAGCTCCAGCTTTAAGGGTTGTGAGCCCCTTGGGGGTTCAGGGAACTGCTTGCCC
1281 AGGGTGCAGTGTGAGTGTGATGGGCCACCGGGGCAAGAGGGAAGGTGACCGCCCAGCTCTCCCACATCCCACTGGATCTG
1361 GCTTACAGGGGGGTCGGAAGCCTGTCCTCACCGTCTCGGGGGTTGTGGCCCCCGCCCCCTCCCTATATGCACCCCTGGAA
1441 CCAGCAAGTCCCAGACAAGGAGAGCGGAGGAGGAAGTCATGGGAACGCAGCCTCCAGTTGTAGCAGGTTTCACTATTCCT
1521 ATGCTGGGGTACACAGTGAGAGTACTCACTTTTCACTTGTCTTGCTCTTAGATTGGGCCATGGCTTTCATCCTGTGTCCC
1601 CTGACCTGTCCAGGTGAGTGTGAGGGCAGCACTGGGAAGCTGGAGTGCTGCTTGTGCCTCCCTTCCCAGTGGGCTGTGTT
1681 GACTGCTGCTCCCCACCCCTACCGATGGTCCCAGGAAGCAGGGAGAGTTGGGGAAGGCAAGATTGGAAAGACAGGAAGAC
1761 CAAGGCCTCGGCAGAACTCTCTGTCTTCTCTCCACTTCTGGTCCCCTGTGGTGATGTGCCTGTAATCTTTTTCTCCACCC
1841 AAACCCCTTCCCACGACAAAAACAAGACTGCCTCCCTCTCTTCCGGGAGCTGGTGACAGCCTTGGGCCTTTCAGTCCCAA
1921 AGCGGCCGATGGGAGTCTCCCTCCGACTCCAGATATGAACAGGGCCCAGGCCTGGAGCGTTTGCTGTGCCAGGAGGCGGC
2001 AGCTCTTCTGGGCAGAGCCTGTCCCCGCCTTCCCTCACTCTTCCTCATCCTGCTTCTCTTTTCCTCGCAGATGATAAAAG
2081 GAATCTGGCATTCTACACCTGGACCATTTGATTGTTTTATTTTGGAATTGGTGTATATCATGAAGCCTTGCTGAACTAAG
2161 TTTTGTGTGTATATATTTAAAAAAAAAATCAGTGTTTAAATAAAGACCTATGTACTTAATCCTTTAACTCTGCGGATAGC
2241 ATTTGGTAGGTAGTGATTAACTGTGAATAATAAATACACAATGAATTCTTCA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uuauucuGGUAGAAAAGGAGUu 5'
                 :|| || ||||||| 
Target 5' ccttcccTCA-CTCTTCCTCAt 3'
2028 - 2048 150.00 -10.60
2
miRNA  3' uuAUUCUGGUAGAAAAGGAGUu 5'
            ||: :||  :|||||||:| 
Target 5' caTAGTGCC--TTTTTCCTTAt 3'
992 - 1011 144.00 -11.80
3
miRNA  3' uuauuCUGGUAGAAAAGGAGUU-- 5'
               | :: ||||||||||:   
Target 5' atcctGCTTCTCTTTTCCTCGCAG 3'
2047 - 2070 135.00 -13.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30534715 8 COSMIC
COSN31523343 27 COSMIC
COSN31492345 29 COSMIC
COSN31520328 54 COSMIC
COSN30520888 79 COSMIC
COSN30505688 83 COSMIC
COSN28785800 114 COSMIC
COSN32055909 119 COSMIC
COSN32055908 120 COSMIC
COSN30104709 130 COSMIC
COSN6111999 213 COSMIC
COSN5420647 367 COSMIC
COSN23271366 487 COSMIC
COSN31588486 839 COSMIC
COSN26642746 963 COSMIC
COSN26669541 992 COSMIC
COSN20114427 1036 COSMIC
COSN1728938 1069 COSMIC
COSN31540813 1086 COSMIC
COSN20114421 1171 COSMIC
COSN26677711 1274 COSMIC
COSN26962239 1575 COSMIC
COSN16500929 1954 COSMIC
COSN23141431 1957 COSMIC
COSN20854227 2081 COSMIC
COSN31602795 2233 COSMIC
COSN31565221 2239 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs182453033 2 dbSNP
rs1164168815 16 dbSNP
rs1396290982 17 dbSNP
rs773915713 17 dbSNP
rs368011954 18 dbSNP
rs772895304 19 dbSNP
rs1333652527 26 dbSNP
rs1362935882 28 dbSNP
rs1176367010 29 dbSNP
rs769304762 30 dbSNP
rs551773522 33 dbSNP
rs1392850916 34 dbSNP
rs1452022116 35 dbSNP
rs777135145 36 dbSNP
rs769044045 39 dbSNP
rs1263118637 40 dbSNP
rs1012813715 44 dbSNP
rs747584778 45 dbSNP
rs200773677 46 dbSNP
rs772614019 47 dbSNP
rs1294464329 49 dbSNP
rs1235725555 51 dbSNP
rs1258323081 58 dbSNP
rs1038289773 62 dbSNP
rs1460644122 63 dbSNP
rs1201227649 68 dbSNP
rs1342685227 71 dbSNP
rs1244489543 75 dbSNP
rs1299790894 79 dbSNP
rs1451418888 81 dbSNP
rs1021950875 86 dbSNP
rs1372825882 95 dbSNP
rs1474633683 96 dbSNP
rs1173019946 103 dbSNP
rs563157141 114 dbSNP
rs888200587 120 dbSNP
rs59083128 121 dbSNP
rs1334745943 133 dbSNP
rs556469416 151 dbSNP
rs1404497482 154 dbSNP
rs929666099 168 dbSNP
rs1317569296 169 dbSNP
rs1407036193 175 dbSNP
rs574224833 177 dbSNP
rs61757950 178 dbSNP
rs1477941814 181 dbSNP
rs1264958755 185 dbSNP
rs1221358161 192 dbSNP
rs1264409440 193 dbSNP
rs1201458853 195 dbSNP
rs1345147297 195 dbSNP
rs762432790 201 dbSNP
rs906051417 204 dbSNP
rs528060879 212 dbSNP
rs1266440900 223 dbSNP
rs139933285 224 dbSNP
rs1174571275 225 dbSNP
rs775680118 234 dbSNP
rs1466632399 237 dbSNP
rs1158130277 238 dbSNP
rs1382694381 239 dbSNP
rs1401814187 241 dbSNP
rs1298561910 244 dbSNP
rs898783069 249 dbSNP
rs1219386426 253 dbSNP
rs1302959582 267 dbSNP
rs1037676570 268 dbSNP
rs940061455 268 dbSNP
rs1320243184 269 dbSNP
rs1276585120 271 dbSNP
rs1381896770 272 dbSNP
rs989719911 279 dbSNP
rs936722313 281 dbSNP
rs1349119035 284 dbSNP
rs1219492738 293 dbSNP
rs371195211 295 dbSNP
rs1287128046 296 dbSNP
rs377745564 302 dbSNP
rs1293910733 321 dbSNP
rs1051188047 326 dbSNP
rs924063240 332 dbSNP
rs978062279 335 dbSNP
rs776063105 336 dbSNP
rs921345953 340 dbSNP
rs1362186101 353 dbSNP
rs1025637501 355 dbSNP
rs991059227 356 dbSNP
rs1163567260 365 dbSNP
rs1364655721 371 dbSNP
rs1422526642 372 dbSNP
rs1465737871 375 dbSNP
rs1295128594 379 dbSNP
rs1367862274 380 dbSNP
rs1425291416 381 dbSNP
rs1304199728 385 dbSNP
rs1167835342 387 dbSNP
rs1242896463 389 dbSNP
rs1310650873 398 dbSNP
rs1359434057 413 dbSNP
rs968940801 418 dbSNP
rs1268408662 428 dbSNP
rs1193348628 430 dbSNP
rs914516024 437 dbSNP
rs959909191 440 dbSNP
rs1016394899 444 dbSNP
rs989108949 447 dbSNP
rs955744610 459 dbSNP
rs879388816 460 dbSNP
rs368741098 469 dbSNP
rs888193731 470 dbSNP
rs1025422274 471 dbSNP
rs373599345 473 dbSNP
rs993820838 474 dbSNP
rs1296121389 477 dbSNP
rs1401775625 479 dbSNP
rs1446870730 486 dbSNP
rs1313830598 487 dbSNP
rs1382659909 488 dbSNP
rs1227156613 489 dbSNP
rs1226896740 493 dbSNP
rs1322733568 498 dbSNP
rs537412183 512 dbSNP
rs776497005 515 dbSNP
rs1313002953 527 dbSNP
rs1199345575 538 dbSNP
rs969822008 541 dbSNP
rs1482221022 544 dbSNP
rs1183546035 545 dbSNP
rs768178752 547 dbSNP
rs1041124708 548 dbSNP
rs1414196481 554 dbSNP
rs1220796543 557 dbSNP
rs942591281 560 dbSNP
rs1168133344 563 dbSNP
rs889707947 575 dbSNP
rs1184268272 577 dbSNP
rs1053617299 578 dbSNP
rs936550167 586 dbSNP
rs924010971 587 dbSNP
rs555279651 588 dbSNP
rs746471080 593 dbSNP
rs1446410996 598 dbSNP
rs1305118229 599 dbSNP
rs978178367 604 dbSNP
rs949485185 605 dbSNP
rs189788463 609 dbSNP
rs1380277416 618 dbSNP
rs995718022 620 dbSNP
rs1485291140 621 dbSNP
rs1276772357 629 dbSNP
rs898642016 632 dbSNP
rs1320230668 636 dbSNP
rs917901954 637 dbSNP
rs555587268 638 dbSNP
rs61757951 639 dbSNP
rs1461165929 643 dbSNP
rs1016965772 644 dbSNP
rs1377897224 646 dbSNP
rs566698670 648 dbSNP
rs1453007327 649 dbSNP
rs746394245 653 dbSNP
rs1179758467 658 dbSNP
rs1426507400 659 dbSNP
rs1459490678 659 dbSNP
rs540342455 661 dbSNP
rs577616506 668 dbSNP
rs188892540 673 dbSNP
rs1360245761 678 dbSNP
rs1430692271 682 dbSNP
rs546799336 686 dbSNP
rs993894448 688 dbSNP
rs1400790488 693 dbSNP
rs921376230 698 dbSNP
rs1365504859 704 dbSNP
rs566242002 707 dbSNP
rs1316252164 711 dbSNP
rs559126755 714 dbSNP
rs1007001256 716 dbSNP
rs889708867 718 dbSNP
rs988754591 721 dbSNP
rs1478842781 725 dbSNP
rs934536242 733 dbSNP
rs571736781 737 dbSNP
rs1419577337 738 dbSNP
rs1000642275 739 dbSNP
rs551810336 742 dbSNP
rs1362769996 744 dbSNP
rs1420705125 747 dbSNP
rs1302981992 758 dbSNP
rs1348331122 760 dbSNP
rs1438941906 762 dbSNP
rs1042222946 763 dbSNP
rs61757952 764 dbSNP
rs918004264 765 dbSNP
rs1055126443 767 dbSNP
rs199956993 770 dbSNP
rs386386623 772 dbSNP
rs55691372 772 dbSNP
rs397700909 773 dbSNP
rs61757953 773 dbSNP
rs938031921 775 dbSNP
rs909451387 776 dbSNP
rs545260161 785 dbSNP
rs962924927 792 dbSNP
rs1375159460 794 dbSNP
rs1177249452 795 dbSNP
rs1159633291 799 dbSNP
rs1382685048 809 dbSNP
rs1440894422 811 dbSNP
rs1163020132 817 dbSNP
rs1389056517 818 dbSNP
rs1442083017 819 dbSNP
rs950960864 820 dbSNP
rs1324460119 827 dbSNP
rs144770299 832 dbSNP
rs1377510031 833 dbSNP
rs1424515306 833 dbSNP
rs1245214720 852 dbSNP
rs1282162910 853 dbSNP
rs1358241766 858 dbSNP
rs1258394353 859 dbSNP
rs1271865104 863 dbSNP
rs529548195 867 dbSNP
rs767527402 879 dbSNP
rs1238312001 881 dbSNP
rs1458570991 890 dbSNP
rs1485477967 890 dbSNP
rs140701411 891 dbSNP
rs1217138800 898 dbSNP
rs1352720505 899 dbSNP
rs1258931296 901 dbSNP
rs1238279807 902 dbSNP
rs981938356 903 dbSNP
rs1395342951 904 dbSNP
rs540401032 904 dbSNP
rs796748637 904 dbSNP
rs769726333 912 dbSNP
rs996870973 917 dbSNP
rs1220116573 921 dbSNP
rs1293630498 921 dbSNP
rs1315661398 921 dbSNP
rs35802432 921 dbSNP
rs879118049 921 dbSNP
rs1444703979 924 dbSNP
rs976255927 927 dbSNP
rs965148681 931 dbSNP
rs1188644003 941 dbSNP
rs1262978156 944 dbSNP
rs573148170 946 dbSNP
rs1043844710 948 dbSNP
rs1354501561 955 dbSNP
rs946756338 956 dbSNP
rs892974317 957 dbSNP
rs1421959050 958 dbSNP
rs1383400044 962 dbSNP
rs1019821046 965 dbSNP
rs1338189419 968 dbSNP
rs577332301 969 dbSNP
rs1278456712 974 dbSNP
rs953873919 975 dbSNP
rs1370211430 985 dbSNP
rs1031982116 988 dbSNP
rs1185909091 988 dbSNP
rs1257289614 994 dbSNP
rs1347726390 995 dbSNP
rs1201551565 1010 dbSNP
rs934506396 1016 dbSNP
rs1000716993 1017 dbSNP
rs1194073498 1019 dbSNP
rs902444088 1027 dbSNP
rs1448474697 1029 dbSNP
rs1259424472 1035 dbSNP
rs1042171337 1036 dbSNP
rs563796855 1037 dbSNP
rs1196804403 1038 dbSNP
rs1432885147 1038 dbSNP
rs774683117 1040 dbSNP
rs948409497 1040 dbSNP
rs1157980902 1049 dbSNP
rs1356968996 1050 dbSNP
rs915549524 1051 dbSNP
rs10611022 1052 dbSNP
rs1309184642 1052 dbSNP
rs138446945 1052 dbSNP
rs1421279301 1052 dbSNP
rs1491152659 1052 dbSNP
rs766371629 1052 dbSNP
rs774728344 1052 dbSNP
rs869101856 1052 dbSNP
rs878922449 1052 dbSNP
rs878975011 1052 dbSNP
rs1426235975 1053 dbSNP
rs1491204884 1053 dbSNP
rs1491378137 1053 dbSNP
rs1491268253 1054 dbSNP
rs1230987644 1057 dbSNP
rs1269470528 1060 dbSNP
rs1452270081 1062 dbSNP
rs1178175007 1067 dbSNP
rs973850827 1070 dbSNP
rs1441516146 1078 dbSNP
rs7219 1081 dbSNP
rs1456023317 1082 dbSNP
rs1055646053 1086 dbSNP
rs938120221 1095 dbSNP
rs1390747081 1099 dbSNP
rs575240583 1109 dbSNP
rs555057966 1112 dbSNP
rs1015335168 1113 dbSNP
rs1375287218 1119 dbSNP
rs1049094391 1121 dbSNP
rs1243010346 1122 dbSNP
rs1308109273 1123 dbSNP
rs1321502755 1134 dbSNP
rs983383424 1135 dbSNP
rs1278490977 1138 dbSNP
rs1469129492 1139 dbSNP
rs1198058638 1140 dbSNP
rs183945271 1145 dbSNP
rs573030908 1155 dbSNP
rs919542138 1158 dbSNP
rs1179209851 1159 dbSNP
rs1255133684 1162 dbSNP
rs368192364 1173 dbSNP
rs11290288 1174 dbSNP
rs373071871 1174 dbSNP
rs397978880 1174 dbSNP
rs1166723150 1178 dbSNP
rs553220410 1186 dbSNP
rs539604304 1193 dbSNP
rs571773457 1194 dbSNP
rs1167889352 1202 dbSNP
rs558331269 1205 dbSNP
rs966635732 1206 dbSNP
rs191656067 1208 dbSNP
rs1449569788 1210 dbSNP
rs912301291 1216 dbSNP
rs573718745 1218 dbSNP
rs1052519522 1225 dbSNP
rs1315326735 1228 dbSNP
rs376345925 1228 dbSNP
rs1335702459 1229 dbSNP
rs747228175 1230 dbSNP
rs1256190979 1233 dbSNP
rs1320097894 1238 dbSNP
rs569271810 1242 dbSNP
rs1173030025 1251 dbSNP
rs1000497129 1252 dbSNP
rs777914803 1253 dbSNP
rs1183347044 1258 dbSNP
rs1256653395 1271 dbSNP
rs1477261958 1278 dbSNP
rs112308534 1282 dbSNP
rs966592745 1294 dbSNP
rs1425079367 1298 dbSNP
rs1392165172 1303 dbSNP
rs186824282 1309 dbSNP
rs758499795 1310 dbSNP
rs1013405547 1319 dbSNP
rs1183641280 1324 dbSNP
rs1359067966 1325 dbSNP
rs896278410 1330 dbSNP
rs1304913040 1331 dbSNP
rs948606433 1333 dbSNP
rs1033534750 1334 dbSNP
rs1399557490 1335 dbSNP
rs1002657553 1336 dbSNP
rs1342674139 1339 dbSNP
rs1215230672 1342 dbSNP
rs1278055196 1343 dbSNP
rs1038476938 1346 dbSNP
rs1452096596 1352 dbSNP
rs887869858 1354 dbSNP
rs1049083066 1355 dbSNP
rs1467607825 1359 dbSNP
rs1487848767 1367 dbSNP
rs529615630 1369 dbSNP
rs1215907724 1371 dbSNP
rs898059897 1372 dbSNP
rs1422476184 1374 dbSNP
rs1431906834 1374 dbSNP
rs1041056675 1375 dbSNP
rs748107869 1376 dbSNP
rs1419464288 1390 dbSNP
rs1234476536 1391 dbSNP
rs181222191 1392 dbSNP
rs1324417924 1393 dbSNP
rs1431810392 1394 dbSNP
rs147253925 1397 dbSNP
rs866783737 1398 dbSNP
rs1330980946 1402 dbSNP
rs369399215 1405 dbSNP
rs982526459 1413 dbSNP
rs1408423489 1416 dbSNP
rs1304052884 1417 dbSNP
rs1419147650 1418 dbSNP
rs1167083622 1420 dbSNP
rs1237652544 1421 dbSNP
rs190279295 1425 dbSNP
rs185424638 1429 dbSNP
rs986319075 1432 dbSNP
rs570140209 1439 dbSNP
rs756069286 1441 dbSNP
rs932360943 1451 dbSNP
rs1396695994 1452 dbSNP
rs1396202278 1460 dbSNP
rs1439660025 1464 dbSNP
rs1157207060 1466 dbSNP
rs1410650216 1467 dbSNP
rs1401460954 1469 dbSNP
rs1191619582 1480 dbSNP
rs180961849 1486 dbSNP
rs35280208 1487 dbSNP
rs1376033609 1500 dbSNP
rs966376212 1502 dbSNP
rs550044557 1515 dbSNP
rs1311135364 1520 dbSNP
rs1020589041 1521 dbSNP
rs1227325107 1523 dbSNP
rs992459731 1529 dbSNP
rs530036763 1535 dbSNP
rs189362846 1536 dbSNP
rs960656505 1537 dbSNP
rs1293129359 1541 dbSNP
rs1431736012 1545 dbSNP
rs1347192084 1547 dbSNP
rs1287284107 1549 dbSNP
rs1235331025 1552 dbSNP
rs1316227707 1553 dbSNP
rs1033896691 1573 dbSNP
rs1237085407 1577 dbSNP
rs1457672100 1580 dbSNP
rs1177346161 1585 dbSNP
rs1234890298 1594 dbSNP
rs1470710456 1596 dbSNP
rs1163111078 1598 dbSNP
rs185635804 1601 dbSNP
rs1003555810 1602 dbSNP
rs907054132 1609 dbSNP
rs1384101134 1612 dbSNP
rs1165536818 1614 dbSNP
rs1045502967 1616 dbSNP
rs1444400512 1619 dbSNP
rs1333301084 1621 dbSNP
rs1336334384 1628 dbSNP
rs1476170035 1630 dbSNP
rs887858390 1632 dbSNP
rs1159480215 1636 dbSNP
rs1415388309 1648 dbSNP
rs1233547565 1649 dbSNP
rs1256824351 1654 dbSNP
rs1315535530 1658 dbSNP
rs1197235446 1663 dbSNP
rs1440176175 1687 dbSNP
rs1275717284 1695 dbSNP
rs1438941835 1700 dbSNP
rs750418078 1703 dbSNP
rs993484842 1704 dbSNP
rs1476289287 1706 dbSNP
rs897801632 1711 dbSNP
rs1040394872 1712 dbSNP
rs1436843792 1728 dbSNP
rs1188934280 1730 dbSNP
rs1422939686 1737 dbSNP
rs944914638 1747 dbSNP
rs1464115807 1755 dbSNP
rs889385010 1760 dbSNP
rs767390659 1769 dbSNP
rs936214820 1770 dbSNP
rs553836699 1772 dbSNP
rs779814410 1783 dbSNP
rs1434025563 1789 dbSNP
rs1331895960 1792 dbSNP
rs1357168763 1793 dbSNP
rs979121315 1793 dbSNP
rs141324646 1795 dbSNP
rs1277194020 1797 dbSNP
rs1380908560 1799 dbSNP
rs1219903880 1803 dbSNP
rs1270318203 1807 dbSNP
rs1340616147 1815 dbSNP
rs1200421720 1818 dbSNP
rs945145379 1821 dbSNP
rs941040148 1831 dbSNP
rs1486867159 1837 dbSNP
rs3211129 1843 dbSNP
rs913528599 1846 dbSNP
rs367852151 1852 dbSNP
rs1262734183 1854 dbSNP
rs751214712 1855 dbSNP
rs1033641160 1863 dbSNP
rs933687460 1866 dbSNP
rs922344960 1878 dbSNP
rs534312310 1884 dbSNP
rs1297400309 1885 dbSNP
rs553259050 1885 dbSNP
rs1278625794 1894 dbSNP
rs546117270 1895 dbSNP
rs182246061 1896 dbSNP
rs774807830 1897 dbSNP
rs1318363057 1900 dbSNP
rs1330010576 1905 dbSNP
rs962124073 1906 dbSNP
rs1273571402 1908 dbSNP
rs1379975403 1923 dbSNP
rs1235438007 1924 dbSNP
rs764755902 1925 dbSNP
rs1287003930 1926 dbSNP
rs557179700 1927 dbSNP
rs1372639579 1935 dbSNP
rs956936859 1939 dbSNP
rs1196919280 1942 dbSNP
rs1396778977 1944 dbSNP
rs755528831 1945 dbSNP
rs889365934 1946 dbSNP
rs1378289010 1959 dbSNP
rs1454965005 1964 dbSNP
rs538368360 1965 dbSNP
rs544534213 1967 dbSNP
rs1416785374 1968 dbSNP
rs1389646049 1970 dbSNP
rs1000415754 1972 dbSNP
rs1310836477 1977 dbSNP
rs555749399 1979 dbSNP
rs1373796490 1982 dbSNP
rs1442309297 1991 dbSNP
rs1041868748 1997 dbSNP
rs1023660407 2000 dbSNP
rs1012725608 2006 dbSNP
rs1043617 2008 dbSNP
rs1161134067 2011 dbSNP
rs1355994784 2020 dbSNP
rs1398892817 2023 dbSNP
rs1345145991 2026 dbSNP
rs1208115801 2027 dbSNP
rs1406520185 2034 dbSNP
rs1177940690 2041 dbSNP
rs894283032 2042 dbSNP
rs535439189 2047 dbSNP
rs1159653922 2049 dbSNP
rs1255020329 2066 dbSNP
rs1367503591 2067 dbSNP
rs1005433049 2073 dbSNP
rs1166404324 2074 dbSNP
rs886776945 2080 dbSNP
rs1244218705 2089 dbSNP
rs1331272472 2094 dbSNP
rs1214205513 2100 dbSNP
rs913684907 2105 dbSNP
rs566825578 2111 dbSNP
rs1046802653 2114 dbSNP
rs1340044382 2121 dbSNP
rs1231723843 2130 dbSNP
rs373206224 2131 dbSNP
rs190021873 2135 dbSNP
rs933638212 2142 dbSNP
rs1056531517 2147 dbSNP
rs1335567952 2153 dbSNP
rs1198157495 2171 dbSNP
rs1316851844 2174 dbSNP
rs1290679935 2176 dbSNP
rs1235281813 2177 dbSNP
rs939053092 2178 dbSNP
rs926519197 2179 dbSNP
rs1039454557 2189 dbSNP
rs138135673 2189 dbSNP
rs550882096 2189 dbSNP
rs760001724 2190 dbSNP
rs1400878248 2191 dbSNP
rs751594902 2193 dbSNP
rs980656737 2208 dbSNP
rs990149360 2210 dbSNP
rs1167998028 2212 dbSNP
rs777168000 2216 dbSNP
rs935559769 2217 dbSNP
rs1463999409 2223 dbSNP
rs1299062315 2225 dbSNP
rs951961636 2230 dbSNP
rs1401953246 2232 dbSNP
rs61757954 2232 dbSNP
rs920387162 2233 dbSNP
rs771271393 2234 dbSNP
rs867324945 2239 dbSNP
rs1428538076 2244 dbSNP
rs982105448 2253 dbSNP
rs372622453 2266 dbSNP
rs971900027 2268 dbSNP
rs1462606308 2272 dbSNP
rs1205169383 2279 dbSNP
rs1415052195 2280 dbSNP
rs1023691458 2281 dbSNP
rs61757955 2282 dbSNP
rs1428750657 2283 dbSNP
rs1422022436 2287 dbSNP
rs1185200466 2290 dbSNP
rs3180472 2291 dbSNP
rs773629882 2292 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' uuauucuGGUAGAAAAGGAGUu 5'
                 :|| || ||||||| 
Target 5' ccuucccUCA-CUCUUCCUCAu 3'
4 - 24
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177622. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_3_12 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000392563.1 | 3UTR | CCGCCUUCCCUCACUCUUCCUCAUCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
111 hsa-miR-3915 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT059544 PIP5K1A phosphatidylinositol-4-phosphate 5-kinase type 1 alpha 2 2
MIRT081703 ZNF507 zinc finger protein 507 2 2
MIRT083311 ZCCHC3 zinc finger CCHC-type containing 3 2 6
MIRT119046 SFT2D3 SFT2 domain containing 3 2 2
MIRT189381 TXLNA taxilin alpha 2 4
MIRT195895 C16ORF72 chromosome 16 open reading frame 72 2 6
MIRT223807 OXR1 oxidation resistance 1 2 2
MIRT292954 ZNF146 zinc finger protein 146 2 4
MIRT293949 RPL13A ribosomal protein L13a 2 6
MIRT300900 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT339332 SESN2 sestrin 2 2 2
MIRT349304 ZNF317 zinc finger protein 317 2 2
MIRT364736 TOR1B torsin family 1 member B 2 2
MIRT366233 VMA21 VMA21, vacuolar ATPase assembly factor 2 2
MIRT384605 CLIC4 chloride intracellular channel 4 2 2
MIRT401745 HLA-DRA major histocompatibility complex, class II, DR alpha 2 2
MIRT443169 UBL3 ubiquitin like 3 2 2
MIRT444215 METTL12 methyltransferase like 12 2 2
MIRT444375 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT445340 TCEANC transcription elongation factor A N-terminal and central domain containing 2 2
MIRT445474 KDM6A lysine demethylase 6A 2 2
MIRT445598 CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 2 2
MIRT445630 TMEM50A transmembrane protein 50A 2 2
MIRT446012 VNN1 vanin 1 2 2
MIRT446115 ASTN1 astrotactin 1 2 2
MIRT446248 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT446382 SYNCRIP synaptotagmin binding cytoplasmic RNA interacting protein 2 2
MIRT446940 ZMAT3 zinc finger matrin-type 3 2 2
MIRT446967 SLCO4C1 solute carrier organic anion transporter family member 4C1 2 2
MIRT447178 PGRMC2 progesterone receptor membrane component 2 2 2
MIRT447209 APBB2 amyloid beta precursor protein binding family B member 2 2 2
MIRT447237 IHH indian hedgehog 2 2
MIRT447807 EMX1 empty spiracles homeobox 1 2 2
MIRT447853 RRP8 ribosomal RNA processing 8 2 4
MIRT448054 MMP15 matrix metallopeptidase 15 2 2
MIRT448094 RASD2 RASD family member 2 2 2
MIRT448704 KLHL11 kelch like family member 11 2 2
MIRT448851 FEM1C fem-1 homolog C 2 2
MIRT449488 ZBTB4 zinc finger and BTB domain containing 4 2 2
MIRT449785 C1orf109 chromosome 1 open reading frame 109 2 2
MIRT450774 PDE3A phosphodiesterase 3A 2 2
MIRT451124 ZNF99 zinc finger protein 99 2 2
MIRT452676 GPR156 G protein-coupled receptor 156 2 2
MIRT452888 PSD4 pleckstrin and Sec7 domain containing 4 2 2
MIRT453188 ACSF2 acyl-CoA synthetase family member 2 2 2
MIRT453353 ZNF3 zinc finger protein 3 2 2
MIRT454502 ZFYVE27 zinc finger FYVE-type containing 27 2 2
MIRT454629 FAM83H family with sequence similarity 83 member H 2 2
MIRT455183 AGTRAP angiotensin II receptor associated protein 2 2
MIRT458204 FOXL2 forkhead box L2 2 2
MIRT458723 CES2 carboxylesterase 2 2 2
MIRT458942 SAMD4B sterile alpha motif domain containing 4B 2 2
MIRT460304 FLCN folliculin 2 2
MIRT460989 SYT7 synaptotagmin 7 2 2
MIRT461697 ZNF426 zinc finger protein 426 2 2
MIRT461903 NECAB3 N-terminal EF-hand calcium binding protein 3 2 2
MIRT462193 NDUFS1 NADH:ubiquinone oxidoreductase core subunit S1 2 2
MIRT462290 PPM1H protein phosphatase, Mg2+/Mn2+ dependent 1H 2 2
MIRT463795 XPOT exportin for tRNA 2 2
MIRT464649 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 4
MIRT465911 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 4
MIRT465992 TMEM189 transmembrane protein 189 2 4
MIRT466302 TIMM22 translocase of inner mitochondrial membrane 22 2 2
MIRT466575 TBC1D2B TBC1 domain family member 2B 2 2
MIRT470558 POU2F1 POU class 2 homeobox 1 2 2
MIRT471333 PERP PERP, TP53 apoptosis effector 2 2
MIRT471659 PALM2 paralemmin 2 2 2
MIRT472363 TSPAN1 tetraspanin 1 2 2
MIRT473468 MCFD2 multiple coagulation factor deficiency 2 2 2
MIRT474702 KIF3A kinesin family member 3A 2 2
MIRT476067 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2 2
MIRT476077 GRB2 growth factor receptor bound protein 2 2 2
MIRT476423 GBA2 glucosylceramidase beta 2 2 2
MIRT476463 GATAD2B GATA zinc finger domain containing 2B 2 2
MIRT477877 DYNLL2 dynein light chain LC8-type 2 2 2
MIRT478240 DDX3X DEAD-box helicase 3, X-linked 2 4
MIRT479460 CDK6 cyclin dependent kinase 6 2 2
MIRT481030 BAZ2A bromodomain adjacent to zinc finger domain 2A 2 2
MIRT491496 HLA-DOA major histocompatibility complex, class II, DO alpha 2 2
MIRT497585 SLC23A1 solute carrier family 23 member 1 2 2
MIRT498542 TMEM30B transmembrane protein 30B 2 2
MIRT499263 NBPF11 NBPF member 11 2 2
MIRT504698 ZNF117 zinc finger protein 117 2 2
MIRT511288 KLHL15 kelch like family member 15 2 4
MIRT523121 HSP90B1 heat shock protein 90 beta family member 1 2 4
MIRT529601 H1F0 H1 histone family member 0 2 2
MIRT533481 TRIM71 tripartite motif containing 71 2 2
MIRT535571 NUP37 nucleoporin 37 2 4
MIRT537869 EDA2R ectodysplasin A2 receptor 2 2
MIRT538010 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT552681 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 4
MIRT554986 RAB39B RAB39B, member RAS oncogene family 2 2
MIRT556659 KMT2D lysine methyltransferase 2D 2 4
MIRT557437 GTPBP2 GTP binding protein 2 2 2
MIRT560813 CRTAP cartilage associated protein 2 2
MIRT562115 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT563103 IFRD2 interferon related developmental regulator 2 2 2
MIRT574199 LMNB1 lamin B1 2 2
MIRT623920 FMNL3 formin like 3 2 2
MIRT626551 NMNAT2 nicotinamide nucleotide adenylyltransferase 2 2 2
MIRT645458 ANKS6 ankyrin repeat and sterile alpha motif domain containing 6 2 2
MIRT649082 CACNA1B calcium voltage-gated channel subunit alpha1 B 2 2
MIRT659477 CLDN1 claudin 1 2 2
MIRT667950 HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 2 2
MIRT701981 MIER3 MIER family member 3 2 2
MIRT708694 TFDP2 transcription factor Dp-2 2 2
MIRT709649 DFFB DNA fragmentation factor subunit beta 2 2
MIRT710090 FAM229B family with sequence similarity 229 member B 2 2
MIRT718396 ALDH1A3 aldehyde dehydrogenase 1 family member A3 2 2
MIRT724972 TNS1 tensin 1 2 2
MIRT756050 HRH4 histamine receptor H4 2 1
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3915 Paclitaxel 36314 NSC125973 approved resistant High Prostate Cancer cell line (DU-145, PC-3)
hsa-miR-3915 Cisplatin + Decitabine sensitive High Non-Small Cell Lung Cancer cell line (A549)
hsa-mir-3915 Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-miR-3915 Tripterygium wilfordii Hook F sensitive tissue
hsa-miR-3915 Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-3915 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3915 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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