miRTarBase - #MIRT476864


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pre-miRNA Information
pre-miRNA hsa-mir-3135b   
Genomic Coordinates chr6: 32749912 - 32749979
Description Homo sapiens miR-3135b stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3135b
Sequence 7| GGCUGGAGCGAGUGCAGUGGUG |28
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1437307191 2 dbSNP
rs1202765326 3 dbSNP
rs905889141 5 dbSNP
rs922757991 8 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol FHL2   
Synonyms AAG11, DRAL, FHL-2, SLIM-3, SLIM3
Description four and a half LIM domains 2
Transcript NM_001039492   
Other Transcripts NM_001450 , NM_201555 , NM_201557   
Expression
Putative miRNA Targets on FHL2
3'UTR of FHL2
(miRNA target sites are highlighted)		 
>FHL2|NM_001039492|3'UTR
   1 ATTCAACACAGAGAAGTTGCTGCTTGTGATCTCACACACAGATTTTTATGTTTTCTTTCTCACCCAGGCAATCTTGCCTT
  81 CTGGTTTCTTCCAGCCACATTGAGACTTTCTTCTAGTGCTTTTCAGTGATACTCACGTTTGCTTAAACCCTTTAGTGCTT
 161 TGTGATAGTTCAGTCCCAGGGAAAGAGAAAACTCGCCCTAGGCCCTAGGTGGGAAGATGGTTTGAAATTTTTGTAATCGA
 241 GTAAGGCACACCCAAATGTAAAAATCCTTTTGAATGATGCCTTTATAAATCTTTCTCTCACTGTCTATTTAAGTGCAATT
 321 AACATATGTCACGAACTTGAAAGTTTTCTAAACTCAATAAGGTAATGACCAGTTGTTATTTACAGCTCTGTAACCTCCCG
 401 TTGCGTCAAGTCTAAACCAAGATTATGTGACTTGCAATAAAGTTATTCAGAACAGAAAAAAAAAAAAAAAAAAAAAAAAA
 481 AAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' guGGUGACGUGAGCGAGGUCGg 5'
            |: ||| ::|: :|||||| 
Target 5' gcCTTCTG-GTTTCTTCCAGCc 3'
 76 - 96 139.00 -20.10
2 
miRNA  3' gugGUGAC-GUG-AGCGAGGUCGG 5'
             ||:||  || |: :||:||: 
Target 5' ccaCATTGAGACTTTCTTCTAGTG 3'
 95 - 118 107.00 -12.20
3 
miRNA  3' guGGUGACGUGAGCGAGGUCGg 5'
            ||| | :::|  :| |||| 
Target 5' gaCCAGT-TGTTATTTACAGCt 3'
 367 - 387 103.00 -10.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30145006 15 COSMIC
COSN4893311 24 COSMIC
COSN31557795 28 COSMIC
COSN8407702 31 COSMIC
COSN30106588 33 COSMIC
COSN31508417 41 COSMIC
COSN31529417 46 COSMIC
COSN24309060 55 COSMIC
COSN30467986 67 COSMIC
COSN30152539 88 COSMIC
COSN30534480 99 COSMIC
COSN6672252 102 COSMIC
COSN30152850 113 COSMIC
COSN31554686 132 COSMIC
COSN31507796 156 COSMIC
COSN31526614 158 COSMIC
COSN30528697 161 COSMIC
COSN5475813 204 COSMIC
COSN31567180 208 COSMIC
COSN31603218 301 COSMIC
COSN8980488 302 COSMIC
COSN31537693 348 COSMIC
COSN31534036 354 COSMIC
COSN7454996 658 COSMIC
COSN8264059 1057 COSMIC
COSN29172841 1103 COSMIC
COSN29176232 1114 COSMIC
COSN7454995 1143 COSMIC
COSN21094280 1495 COSMIC
COSN6150649 1698 COSMIC
COSN1776104 1790 COSMIC
COSN1221025 2099 COSMIC
COSN26494470 2194 COSMIC
COSN7454994 2361 COSMIC
COSN1776103 2464 COSMIC
COSN24780088 2883 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1257674816 9 dbSNP
rs199691250 13 dbSNP
rs756430758 16 dbSNP
rs368824523 30 dbSNP
rs781750373 31 dbSNP
rs757735612 33 dbSNP
rs752238903 37 dbSNP
rs1463367047 40 dbSNP
rs1290529530 41 dbSNP
rs1000798237 50 dbSNP
rs775963548 50 dbSNP
rs1453217065 63 dbSNP
rs1338143273 83 dbSNP
rs530518744 84 dbSNP
rs1392063589 92 dbSNP
rs1295912741 94 dbSNP
rs1308864748 98 dbSNP
rs903741979 100 dbSNP
rs1398684313 101 dbSNP
rs939760066 101 dbSNP
rs1204821226 104 dbSNP
rs1239304356 107 dbSNP
rs1484960127 109 dbSNP
rs1297009989 110 dbSNP
rs778092790 113 dbSNP
rs879204828 116 dbSNP
rs1478919170 118 dbSNP
rs1174014635 131 dbSNP
rs1428264194 132 dbSNP
rs11537577 134 dbSNP
rs945037275 136 dbSNP
rs890907386 137 dbSNP
rs1167556039 147 dbSNP
rs908299857 148 dbSNP
rs1416748178 149 dbSNP
rs1182034016 155 dbSNP
rs1363652833 165 dbSNP
rs1402641267 166 dbSNP
rs1050850135 168 dbSNP
rs758826156 172 dbSNP
rs1247782423 175 dbSNP
rs932361126 176 dbSNP
rs1224479747 177 dbSNP
rs753215391 180 dbSNP
rs952578481 181 dbSNP
rs926496385 182 dbSNP
rs765710296 184 dbSNP
rs1261329295 185 dbSNP
rs980674894 187 dbSNP
rs2278500 194 dbSNP
rs909455005 195 dbSNP
rs983479116 196 dbSNP
rs1192678906 200 dbSNP
rs757512099 201 dbSNP
rs1405788849 216 dbSNP
rs546996537 227 dbSNP
rs1024955854 233 dbSNP
rs1159200732 237 dbSNP
rs992268924 238 dbSNP
rs956979827 239 dbSNP
rs529805708 245 dbSNP
rs1302196363 251 dbSNP
rs1365774780 253 dbSNP
rs959687850 264 dbSNP
rs1276958386 266 dbSNP
rs1283860422 270 dbSNP
rs1371832019 273 dbSNP
rs1033521747 282 dbSNP
rs1001106034 288 dbSNP
rs1307840926 293 dbSNP
rs1373862633 295 dbSNP
rs1337671446 303 dbSNP
rs1220324042 322 dbSNP
rs542257095 324 dbSNP
rs183756866 332 dbSNP
rs11537579 333 dbSNP
rs1230896745 337 dbSNP
rs1395874415 345 dbSNP
rs1044097 348 dbSNP
rs1177663064 353 dbSNP
rs1009213718 357 dbSNP
rs1162368723 362 dbSNP
rs559524401 366 dbSNP
rs1390428008 370 dbSNP
rs540935979 375 dbSNP
rs577099490 377 dbSNP
rs1325951807 385 dbSNP
rs1158839319 392 dbSNP
rs558160021 397 dbSNP
rs766063018 399 dbSNP
rs1332692675 400 dbSNP
rs1379725875 404 dbSNP
rs777604080 405 dbSNP
rs1314453027 406 dbSNP
rs932428413 421 dbSNP
rs1360441266 431 dbSNP
rs1230197110 432 dbSNP
rs899574331 434 dbSNP
rs546264176 441 dbSNP
rs1180477880 448 dbSNP
rs1204918723 450 dbSNP
rs773058177 459 dbSNP
rs942158903 465 dbSNP
rs909494051 466 dbSNP
rs1254844626 472 dbSNP
rs939720033 485 dbSNP
rs908248135 493 dbSNP
rs1473593337 495 dbSNP
rs771990202 498 dbSNP
rs1165744450 499 dbSNP
rs1048149550 515 dbSNP
rs931087687 518 dbSNP
rs926438832 526 dbSNP
rs980622332 530 dbSNP
rs1284675989 531 dbSNP
rs545800352 532 dbSNP
rs970621766 535 dbSNP
rs1451025552 540 dbSNP
rs1336193964 561 dbSNP
rs917855107 567 dbSNP
rs988118893 573 dbSNP
rs956736287 593 dbSNP
rs1219072428 597 dbSNP
rs1032808289 600 dbSNP
rs1321341048 606 dbSNP
rs929520528 608 dbSNP
rs953627539 613 dbSNP
rs575797400 616 dbSNP
rs557448899 623 dbSNP
rs992533551 627 dbSNP
rs535956014 628 dbSNP
rs1426176757 629 dbSNP
rs568532424 635 dbSNP
rs146492348 637 dbSNP
rs1403490726 638 dbSNP
rs967840371 647 dbSNP
rs1020713417 648 dbSNP
rs1306324246 652 dbSNP
rs1009444449 661 dbSNP
rs1400767939 670 dbSNP
rs1004251282 672 dbSNP
rs534985326 679 dbSNP
rs1222651857 680 dbSNP
rs868738452 681 dbSNP
rs1256558269 683 dbSNP
rs1347035694 684 dbSNP
rs1202916644 685 dbSNP
rs1330947616 691 dbSNP
rs1319388479 694 dbSNP
rs1218276173 703 dbSNP
rs1266294210 705 dbSNP
rs1402740182 706 dbSNP
rs1199142847 713 dbSNP
rs1378775763 714 dbSNP
rs1479256441 718 dbSNP
rs758308832 720 dbSNP
rs886767995 725 dbSNP
rs1048574126 728 dbSNP
rs931057392 733 dbSNP
rs571171036 736 dbSNP
rs551747536 737 dbSNP
rs371436181 741 dbSNP
rs530385928 744 dbSNP
rs569315595 745 dbSNP
rs759638777 751 dbSNP
rs367835825 762 dbSNP
rs899606048 765 dbSNP
rs1241640021 766 dbSNP
rs1242565100 766 dbSNP
rs1038516553 770 dbSNP
rs374388549 774 dbSNP
rs1005277469 776 dbSNP
rs1268410501 777 dbSNP
rs1453865158 778 dbSNP
rs1363707128 779 dbSNP
rs1445020405 780 dbSNP
rs1160528491 781 dbSNP
rs191042649 782 dbSNP
rs1424196664 790 dbSNP
rs1047887054 801 dbSNP
rs1392572500 802 dbSNP
rs752675068 806 dbSNP
rs929551597 826 dbSNP
rs918155133 833 dbSNP
rs1056506675 834 dbSNP
rs1377544457 834 dbSNP
rs1425928207 841 dbSNP
rs1312208010 844 dbSNP
rs1358290010 845 dbSNP
rs370111688 859 dbSNP
rs925305017 866 dbSNP
rs1433361443 873 dbSNP
rs926754489 878 dbSNP
rs1238173757 880 dbSNP
rs1458598773 881 dbSNP
rs1325013210 887 dbSNP
rs1180606447 892 dbSNP
rs1297247425 895 dbSNP
rs979866616 901 dbSNP
rs1423496193 902 dbSNP
rs1165807069 906 dbSNP
rs953450768 908 dbSNP
rs1460331019 914 dbSNP
rs1167089628 916 dbSNP
rs1400957504 917 dbSNP
rs1181628906 918 dbSNP
rs1448815813 918 dbSNP
rs1381338133 932 dbSNP
rs1482110740 937 dbSNP
rs1324316657 942 dbSNP
rs1225771232 945 dbSNP
rs1376816118 958 dbSNP
rs1310543761 960 dbSNP
rs1257763531 962 dbSNP
rs1413349543 962 dbSNP
rs1420166253 963 dbSNP
rs1261368399 964 dbSNP
rs1482988087 964 dbSNP
rs1169537911 965 dbSNP
rs1029051443 967 dbSNP
rs1258596072 974 dbSNP
rs76268450 979 dbSNP
rs1474326980 981 dbSNP
rs1192671827 982 dbSNP
rs1424019379 982 dbSNP
rs1448726225 982 dbSNP
rs878876756 982 dbSNP
rs878888921 982 dbSNP
rs1216765720 983 dbSNP
rs1422630335 984 dbSNP
rs112004931 990 dbSNP
rs1220812038 991 dbSNP
rs1486120765 994 dbSNP
rs1312106939 998 dbSNP
rs1259795424 1002 dbSNP
rs1208132903 1003 dbSNP
rs966189992 1017 dbSNP
rs780500623 1020 dbSNP
rs1274368557 1022 dbSNP
rs1015078104 1027 dbSNP
rs553585021 1028 dbSNP
rs12476475 1029 dbSNP
rs1424446924 1039 dbSNP
rs1277958663 1041 dbSNP
rs1177613701 1042 dbSNP
rs1234211111 1043 dbSNP
rs1026636589 1048 dbSNP
rs1298487772 1049 dbSNP
rs62152060 1050 dbSNP
rs1301612355 1051 dbSNP
rs543748813 1056 dbSNP
rs377647070 1057 dbSNP
rs1303527671 1058 dbSNP
rs542694294 1059 dbSNP
rs1239480007 1064 dbSNP
rs765975092 1066 dbSNP
rs541924182 1069 dbSNP
rs373510238 1073 dbSNP
rs1219993795 1075 dbSNP
rs1044841734 1102 dbSNP
rs987928244 1106 dbSNP
rs955359025 1109 dbSNP
rs1408128576 1113 dbSNP
rs768502400 1115 dbSNP
rs144492081 1120 dbSNP
rs1192803434 1124 dbSNP
rs553289161 1125 dbSNP
rs535263208 1126 dbSNP
rs1420326100 1137 dbSNP
rs878886495 1143 dbSNP
rs1381789869 1147 dbSNP
rs1052738261 1151 dbSNP
rs1180300281 1155 dbSNP
rs1322021343 1158 dbSNP
rs935245691 1170 dbSNP
rs1016576568 1175 dbSNP
rs773494868 1179 dbSNP
rs1005308526 1191 dbSNP
rs772483883 1194 dbSNP
rs536094785 1199 dbSNP
rs979433021 1201 dbSNP
rs886823955 1209 dbSNP
rs1257911590 1210 dbSNP
rs776701416 1212 dbSNP
rs1309999653 1213 dbSNP
rs1047957996 1217 dbSNP
rs1356130477 1227 dbSNP
rs1337356198 1236 dbSNP
rs1288912472 1239 dbSNP
rs1291100125 1246 dbSNP
rs537903316 1250 dbSNP
rs921986549 1251 dbSNP
rs577033997 1257 dbSNP
rs1239423292 1263 dbSNP
rs1442420507 1268 dbSNP
rs1162332124 1273 dbSNP
rs1439316627 1285 dbSNP
rs1406385365 1288 dbSNP
rs187042485 1289 dbSNP
rs1376085607 1310 dbSNP
rs966136837 1318 dbSNP
rs771052592 1329 dbSNP
rs537372626 1331 dbSNP
rs1057104230 1371 dbSNP
rs182050060 1377 dbSNP
rs1379149730 1379 dbSNP
rs1445889324 1387 dbSNP
rs952299676 1389 dbSNP
rs12476328 1396 dbSNP
rs1043676429 1397 dbSNP
rs1391982524 1402 dbSNP
rs1270537994 1412 dbSNP
rs535941854 1414 dbSNP
rs1199139916 1415 dbSNP
rs1259886221 1433 dbSNP
rs1459620803 1438 dbSNP
rs946838688 1451 dbSNP
rs373133825 1469 dbSNP
rs904869656 1470 dbSNP
rs1023342549 1486 dbSNP
rs145841286 1489 dbSNP
rs1465584931 1501 dbSNP
rs189702879 1504 dbSNP
rs896261220 1505 dbSNP
rs532291442 1531 dbSNP
rs1412909365 1532 dbSNP
rs1238133488 1553 dbSNP
rs1333519408 1556 dbSNP
rs1359965228 1558 dbSNP
rs748481682 1561 dbSNP
rs114813575 1564 dbSNP
rs116033554 1566 dbSNP
rs1280091563 1568 dbSNP
rs1342770647 1571 dbSNP
rs1199402484 1579 dbSNP
rs1278634292 1580 dbSNP
rs1443819748 1586 dbSNP
rs975755305 1589 dbSNP
rs779434468 1593 dbSNP
rs1261995948 1594 dbSNP
rs963956422 1607 dbSNP
rs921932557 1608 dbSNP
rs185236251 1612 dbSNP
rs1172095502 1613 dbSNP
rs944778527 1619 dbSNP
rs149854162 1621 dbSNP
rs951149090 1640 dbSNP
rs1025379805 1645 dbSNP
rs1400446202 1647 dbSNP
rs1299748706 1653 dbSNP
rs574828810 1660 dbSNP
rs952317511 1661 dbSNP
rs1274952817 1662 dbSNP
rs920824790 1669 dbSNP
rs1346573418 1670 dbSNP
rs980344407 1685 dbSNP
rs896658116 1692 dbSNP
rs1035168595 1703 dbSNP
rs1442989899 1713 dbSNP
rs1368595775 1727 dbSNP
rs1002869031 1728 dbSNP
rs1198834903 1730 dbSNP
rs970337201 1734 dbSNP
rs1479085272 1739 dbSNP
rs905438295 1743 dbSNP
rs1023288426 1751 dbSNP
rs1379931906 1762 dbSNP
rs1420466399 1766 dbSNP
rs1160271358 1772 dbSNP
rs1013288025 1774 dbSNP
rs1043748800 1782 dbSNP
rs1324174639 1783 dbSNP
rs1031170077 1786 dbSNP
rs1444016903 1801 dbSNP
rs946702889 1805 dbSNP
rs999331125 1810 dbSNP
rs1241803205 1818 dbSNP
rs903676227 1822 dbSNP
rs1292733765 1828 dbSNP
rs1354732921 1829 dbSNP
rs892580518 1833 dbSNP
rs1431119470 1841 dbSNP
rs1268735075 1842 dbSNP
rs1346033348 1855 dbSNP
rs1161503283 1858 dbSNP
rs2460258 1862 dbSNP
rs1379743444 1872 dbSNP
rs1043605274 1875 dbSNP
rs1174882776 1876 dbSNP
rs1052486913 1887 dbSNP
rs934067936 1895 dbSNP
rs1180802068 1903 dbSNP
rs559758980 1905 dbSNP
rs922430859 1908 dbSNP
rs773718617 1911 dbSNP
rs1163613464 1919 dbSNP
rs996028535 1921 dbSNP
rs1463960083 1922 dbSNP
rs1330115433 1924 dbSNP
rs1377055132 1931 dbSNP
rs1448307982 1939 dbSNP
rs765974276 1941 dbSNP
rs1190997602 1948 dbSNP
rs1486371262 1950 dbSNP
rs1287643553 1962 dbSNP
rs1339494179 1964 dbSNP
rs1244532929 1965 dbSNP
rs1266335121 1989 dbSNP
rs1337627411 1990 dbSNP
rs749401706 1992 dbSNP
rs900453003 1994 dbSNP
rs568752387 1997 dbSNP
rs1352410578 2004 dbSNP
rs866668899 2007 dbSNP
rs975239900 2010 dbSNP
rs1254408804 2012 dbSNP
rs942645674 2016 dbSNP
rs909796903 2018 dbSNP
rs1310378433 2021 dbSNP
rs1419692885 2022 dbSNP
rs1476703834 2027 dbSNP
rs944726194 2029 dbSNP
rs1214976013 2032 dbSNP
rs541170957 2039 dbSNP
rs35606673 2084 dbSNP
rs780996033 2084 dbSNP
rs1300337130 2091 dbSNP
rs1401060285 2094 dbSNP
rs1398370228 2099 dbSNP
rs1396212408 2100 dbSNP
rs1360054077 2106 dbSNP
rs1313913434 2112 dbSNP
rs1357813710 2113 dbSNP
rs983810333 2115 dbSNP
rs951012985 2116 dbSNP
rs1350972778 2117 dbSNP
rs1313566461 2119 dbSNP
rs960202615 2121 dbSNP
rs1025284009 2129 dbSNP
rs1376458715 2134 dbSNP
rs576996787 2137 dbSNP
rs1483058177 2142 dbSNP
rs755752311 2143 dbSNP
rs959775805 2144 dbSNP
rs183806971 2147 dbSNP
rs1002375325 2149 dbSNP
rs970284770 2154 dbSNP
rs866431172 2158 dbSNP
rs991801283 2169 dbSNP
rs558744175 2180 dbSNP
rs960659391 2182 dbSNP
rs571146288 2184 dbSNP
rs1466086701 2186 dbSNP
rs1022492152 2188 dbSNP
rs72823875 2190 dbSNP
rs150672820 2191 dbSNP
rs1212427280 2195 dbSNP
rs1481965624 2204 dbSNP
rs1052407857 2206 dbSNP
rs536283550 2211 dbSNP
rs192416609 2215 dbSNP
rs995977589 2216 dbSNP
rs1311715387 2217 dbSNP
rs900402194 2221 dbSNP
rs1205108580 2227 dbSNP
rs1282805333 2228 dbSNP
rs1040272038 2230 dbSNP
rs1309099681 2233 dbSNP
rs1039982702 2242 dbSNP
rs76884682 2243 dbSNP
rs74959968 2244 dbSNP
rs74445785 2245 dbSNP
rs942530530 2247 dbSNP
rs1217719456 2250 dbSNP
rs909828104 2251 dbSNP
rs1340140352 2261 dbSNP
rs547420597 2266 dbSNP
rs929852718 2267 dbSNP
rs538376182 2269 dbSNP
rs1418649781 2270 dbSNP
rs36099361 2277 dbSNP
rs960100999 2278 dbSNP
rs1302828868 2279 dbSNP
rs1034087236 2280 dbSNP
rs79154358 2281 dbSNP
rs2576777 2284 dbSNP
rs567607877 2289 dbSNP
rs549017002 2290 dbSNP
rs775469385 2292 dbSNP
rs1318545604 2293 dbSNP
rs530058633 2293 dbSNP
rs1219106222 2294 dbSNP
rs570672840 2299 dbSNP
rs948884727 2299 dbSNP
rs1031453192 2301 dbSNP
rs1194965107 2306 dbSNP
rs1235789039 2312 dbSNP
rs186645533 2325 dbSNP
rs1189585780 2346 dbSNP
rs770962812 2347 dbSNP
rs1402863811 2354 dbSNP
rs1163048667 2358 dbSNP
rs541482731 2361 dbSNP
rs901275471 2363 dbSNP
rs532506034 2366 dbSNP
rs1254853369 2371 dbSNP
rs1022068285 2387 dbSNP
rs1039777303 2396 dbSNP
rs1196379952 2397 dbSNP
rs1006949496 2399 dbSNP
rs10209781 2414 dbSNP
rs1197805495 2420 dbSNP
rs543652423 2421 dbSNP
rs1311668068 2423 dbSNP
rs1048216255 2424 dbSNP
rs1456980643 2428 dbSNP
rs968171652 2429 dbSNP
rs1022018084 2435 dbSNP
rs974507501 2442 dbSNP
rs964524275 2454 dbSNP
rs929883734 2460 dbSNP
rs1475722036 2463 dbSNP
rs576316893 2465 dbSNP
rs1009229324 2481 dbSNP
rs1465227144 2483 dbSNP
rs918506901 2485 dbSNP
rs1356503184 2506 dbSNP
rs1446024634 2515 dbSNP
rs1283409696 2520 dbSNP
rs1355909956 2521 dbSNP
rs1234895232 2529 dbSNP
rs1057227393 2530 dbSNP
rs938349150 2535 dbSNP
rs1218724727 2542 dbSNP
rs886383779 2544 dbSNP
rs1274441332 2555 dbSNP
rs555201511 2556 dbSNP
rs1209036487 2566 dbSNP
rs1237672491 2569 dbSNP
rs979895067 2574 dbSNP
rs1190505856 2575 dbSNP
rs1379789880 2585 dbSNP
rs1477745913 2597 dbSNP
rs1329855601 2601 dbSNP
rs1421686304 2610 dbSNP
rs1412798380 2616 dbSNP
rs878944667 2617 dbSNP
rs1465468485 2626 dbSNP
rs1333830954 2630 dbSNP
rs1376290966 2631 dbSNP
rs968400840 2633 dbSNP
rs915418524 2634 dbSNP
rs989600718 2642 dbSNP
rs1296055994 2646 dbSNP
rs764192918 2646 dbSNP
rs1431339099 2651 dbSNP
rs542953267 2662 dbSNP
rs2679884 2679 dbSNP
rs1271825870 2683 dbSNP
rs1342323769 2684 dbSNP
rs1218115937 2686 dbSNP
rs773372804 2689 dbSNP
rs371893069 2698 dbSNP
rs1349513761 2704 dbSNP
rs1031234947 2708 dbSNP
rs772213941 2717 dbSNP
rs965418926 2725 dbSNP
rs899225133 2734 dbSNP
rs1367463495 2735 dbSNP
rs571978419 2748 dbSNP
rs1018666220 2756 dbSNP
rs1181923568 2761 dbSNP
rs2576776 2762 dbSNP
rs888496772 2766 dbSNP
rs948816058 2771 dbSNP
rs1236320807 2774 dbSNP
rs538721598 2775 dbSNP
rs895983328 2780 dbSNP
rs1258991727 2791 dbSNP
rs1395938771 2799 dbSNP
rs1436768627 2810 dbSNP
rs1057343850 2821 dbSNP
rs934895314 2824 dbSNP
rs1382551299 2827 dbSNP
rs1320274823 2833 dbSNP
rs1048290206 2836 dbSNP
rs747893227 2837 dbSNP
rs75668800 2839 dbSNP
rs897095300 2843 dbSNP
rs946405093 2844 dbSNP
rs778997742 2848 dbSNP
rs914960330 2851 dbSNP
rs1057063644 2852 dbSNP
rs1207773026 2864 dbSNP
rs974458511 2867 dbSNP
rs964472061 2869 dbSNP
rs1265030821 2873 dbSNP
rs1239896156 2874 dbSNP
rs568870680 2877 dbSNP
rs36122701 2879 dbSNP
rs987351671 2884 dbSNP
rs779158603 2886 dbSNP
rs537998314 2890 dbSNP
rs374424405 2891 dbSNP
rs1044006089 2897 dbSNP
rs531798618 2899 dbSNP
rs1379906132 2902 dbSNP
rs914319683 2909 dbSNP
rs1325949918 2912 dbSNP
rs1160017081 2914 dbSNP
rs989630503 2922 dbSNP
rs755429531 2924 dbSNP
rs924075734 2930 dbSNP
rs977048901 2931 dbSNP
rs965973003 2935 dbSNP
rs1396078151 2937 dbSNP
rs1443904347 2938 dbSNP
rs1308167913 2940 dbSNP
rs1018281460 2946 dbSNP
rs1240227904 2966 dbSNP
rs1281589109 2972 dbSNP
rs1354903362 2978 dbSNP
rs1158969630 2980 dbSNP
rs985448984 2988 dbSNP
rs899155244 2995 dbSNP
rs1378427858 2996 dbSNP
rs749808925 2998 dbSNP
rs1469925065 3004 dbSNP
rs1196825008 3006 dbSNP
rs1250085924 3009 dbSNP
rs1419833020 3029 dbSNP
rs562769767 3031 dbSNP
rs1012987446 3051 dbSNP
rs1472323399 3054 dbSNP
rs1027061466 3061 dbSNP
rs999049857 3062 dbSNP
rs1396798519 3064 dbSNP
rs1392735109 3067 dbSNP
rs994226520 3068 dbSNP
rs1043320699 3069 dbSNP
rs903392072 3069 dbSNP
rs1294511741 3086 dbSNP
rs754922461 3089 dbSNP
rs1206116249 3090 dbSNP
rs1337499315 3090 dbSNP
rs947676291 3091 dbSNP
rs12474144 3094 dbSNP
rs914908124 3102 dbSNP
rs1038701374 3103 dbSNP
rs1284511225 3109 dbSNP
rs943112221 3113 dbSNP
rs897006624 3116 dbSNP
rs987686983 3119 dbSNP
rs1348668165 3125 dbSNP
rs1419960553 3136 dbSNP
rs1476773642 3139 dbSNP
rs567353883 3147 dbSNP
rs755666124 3150 dbSNP
rs1169177424 3151 dbSNP
rs759633306 3158 dbSNP
rs1276736137 3160 dbSNP
rs950583523 3164 dbSNP
rs1035893454 3169 dbSNP
rs1463052773 3178 dbSNP
rs1231293619 3180 dbSNP
rs1002801049 3186 dbSNP
rs1313807013 3188 dbSNP
rs72945003 3189 dbSNP
rs1318664622 3193 dbSNP
rs1295452888 3199 dbSNP
rs1044081231 3202 dbSNP
rs1229681036 3206 dbSNP
rs1254551062 3210 dbSNP
rs142435725 3219 dbSNP
rs1297496586 3227 dbSNP
rs1259309143 3231 dbSNP
rs779974109 3232 dbSNP
rs1185911269 3248 dbSNP
rs1262331035 3252 dbSNP
rs1429847584 3254 dbSNP
rs1196050060 3261 dbSNP
rs749978395 3265 dbSNP
rs1170332672 3273 dbSNP
rs1434898705 3277 dbSNP
rs1174691947 3284 dbSNP
rs1477464419 3286 dbSNP
rs1052814741 3292 dbSNP
rs1418226089 3302 dbSNP
rs566052040 3309 dbSNP
rs934381163 3314 dbSNP
rs1012935144 3318 dbSNP
rs1479004700 3332 dbSNP
rs1384013187 3337 dbSNP
rs1261553309 3341 dbSNP
rs924134240 3347 dbSNP
rs960085402 3357 dbSNP
rs977289294 3364 dbSNP
rs944335873 3367 dbSNP
rs139237155 3371 dbSNP
rs1280774911 3378 dbSNP
rs1214799479 3385 dbSNP
rs999394268 3386 dbSNP
rs1198819100 3388 dbSNP
rs985490001 3396 dbSNP
rs1251788172 3407 dbSNP
rs1454308052 3415 dbSNP
rs1195161156 3416 dbSNP
rs1378081761 3418 dbSNP
rs182053140 3420 dbSNP
rs1158745850 3430 dbSNP
rs1346332657 3432 dbSNP
rs1026965124 3444 dbSNP
rs972817186 3451 dbSNP
rs565075625 3458 dbSNP
rs1455773569 3466 dbSNP
rs543517376 3468 dbSNP
rs189415933 3484 dbSNP
rs1035563672 3488 dbSNP
rs1305988370 3494 dbSNP
rs1374865068 3495 dbSNP
rs1223014453 3498 dbSNP
rs73945097 3503 dbSNP
rs905803134 3507 dbSNP
rs1219330474 3510 dbSNP
rs1272448690 3514 dbSNP
rs1038646520 3541 dbSNP
rs943058168 3544 dbSNP
rs1277376746 3555 dbSNP
rs1415284107 3560 dbSNP
rs62155875 3562 dbSNP
rs1331561096 3563 dbSNP
rs63302162 3564 dbSNP
rs561343624 3566 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 2274.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065669. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' guGGUGACGUGAGCGAGGUCgg 5'
            ||||||||    ||||||  
Target 5' agCCACUGCA----CUCCAG-- 3'
 		5 - 20
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' guGGUGACGUGAGCGAGGUCGg 5'
            ||||||||    ||||||| 
Target 5' agCCACUGCA----CUCCAGCc 3'
 		10 - 27
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1065669
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_8
Location of target site ENST00000409177.1 | 3UTR | GAACAGCCACUGCACUCCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000409177.1 | 3UTR | CCUGUGAACAGCCACUGCACUCCAGCCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
305 hsa-miR-3135b Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT079084 BIRC5 baculoviral IAP repeat containing 5 2 6
MIRT118055 SLC1A5 solute carrier family 1 member 5 2 2
MIRT195529 SNTB2 syntrophin beta 2 2 2
MIRT312491 SLC26A2 solute carrier family 26 member 2 2 2
MIRT366306 GDI1 GDP dissociation inhibitor 1 2 4
MIRT448908 CLCN6 chloride voltage-gated channel 6 2 4
MIRT451874 SOD2 superoxide dismutase 2 2 8
MIRT454235 OSBPL10 oxysterol binding protein like 10 2 15
MIRT454512 ZFYVE27 zinc finger FYVE-type containing 27 2 2
MIRT457728 SMOX spermine oxidase 2 2
MIRT459797 POTED POTE ankyrin domain family member D 2 10
MIRT459905 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 12
MIRT462667 HMOX1 heme oxygenase 1 2 2
MIRT466798 SUPT16H SPT16 homolog, facilitates chromatin remodeling subunit 2 2
MIRT468954 RPS14 ribosomal protein S14 2 2
MIRT469458 REL REL proto-oncogene, NF-kB subunit 2 6
MIRT470214 PRRC2B proline rich coiled-coil 2B 2 2
MIRT470503 PPP1R11 protein phosphatase 1 regulatory inhibitor subunit 11 2 2
MIRT476142 GPR137C G protein-coupled receptor 137C 2 8
MIRT476864 FHL2 four and a half LIM domains 2 2 4
MIRT478052 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 10
MIRT480647 BSCL2 BSCL2, seipin lipid droplet biogenesis associated 2 2
MIRT488513 CD3E CD3e molecule 2 2
MIRT497664 PRMT3 protein arginine methyltransferase 3 2 2
MIRT498656 AP3B2 adaptor related protein complex 3 beta 2 subunit 2 6
MIRT499315 ZNF485 zinc finger protein 485 2 10
MIRT499761 CIRH1A UTP4, small subunit processome component 2 8
MIRT501131 SLC2A1 solute carrier family 2 member 1 2 2
MIRT502292 GNG12 G protein subunit gamma 12 2 6
MIRT503452 PNMA2 paraneoplastic Ma antigen 2 2 6
MIRT507072 H2AFX H2A histone family member X 2 4
MIRT509947 TOMM70A translocase of outer mitochondrial membrane 70 2 6
MIRT514508 SHISA9 shisa family member 9 2 4
MIRT515507 GTF2F1 general transcription factor IIF subunit 1 2 2
MIRT515912 MFAP2 microfibril associated protein 2 2 2
MIRT516412 COPA coatomer protein complex subunit alpha 2 2
MIRT516477 RAB32 RAB32, member RAS oncogene family 2 2
MIRT517863 NCAPD2 non-SMC condensin I complex subunit D2 2 4
MIRT518785 MED16 mediator complex subunit 16 2 4
MIRT518952 GRK7 G protein-coupled receptor kinase 7 2 2
MIRT519227 PYCARD PYD and CARD domain containing 2 2
MIRT522561 MCAM melanoma cell adhesion molecule 2 4
MIRT523767 FBXO27 F-box protein 27 2 4
MIRT528364 ZMYM1 zinc finger MYM-type containing 1 2 4
MIRT529369 YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta 2 4
MIRT529978 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 2
MIRT530454 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT531643 C19orf52 translocase of inner mitochondrial membrane 29 2 4
MIRT531751 TXK TXK tyrosine kinase 2 2
MIRT531915 SLC4A1 solute carrier family 4 member 1 (Diego blood group) 2 2
MIRT532024 FHDC1 FH2 domain containing 1 2 2
MIRT533117 YIPF4 Yip1 domain family member 4 2 4
MIRT534713 RFX7 regulatory factor X7 2 2
MIRT535473 PARVB parvin beta 2 6
MIRT535769 MYCN MYCN proto-oncogene, bHLH transcription factor 2 2
MIRT536744 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT537943 DSN1 DSN1 homolog, MIS12 kinetochore complex component 2 2
MIRT539525 ABCF1 ATP binding cassette subfamily F member 1 2 4
MIRT540255 FAM89A family with sequence similarity 89 member A 2 2
MIRT540440 RBM43 RNA binding motif protein 43 2 2
MIRT542984 ERC1 ELKS/RAB6-interacting/CAST family member 1 2 2
MIRT543426 LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 2 2
MIRT544676 AP1S1 adaptor related protein complex 1 sigma 1 subunit 2 2
MIRT544727 NDRG1 N-myc downstream regulated 1 2 2
MIRT545196 HIST1H2BD histone cluster 1 H2B family member d 2 2
MIRT553254 TVP23C trans-golgi network vesicle protein 23 homolog C 2 2
MIRT553277 TVP23B trans-golgi network vesicle protein 23 homolog B 2 2
MIRT565018 VIM vimentin 2 2
MIRT565931 SAMD4B sterile alpha motif domain containing 4B 2 2
MIRT569796 CSF1 colony stimulating factor 1 2 2
MIRT570259 PRSS16 protease, serine 16 2 2
MIRT570785 ORC6 origin recognition complex subunit 6 2 2
MIRT571144 HM13 histocompatibility minor 13 2 2
MIRT572818 MYO1C myosin IC 2 2
MIRT575204 Entpd4 ectonucleoside triphosphate diphosphohydrolase 4 2 3
MIRT575284 Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 2 2
MIRT575304 Osbpl10 oxysterol binding protein-like 10 2 9
MIRT575325 Fbxo6 F-box protein 6 2 2
MIRT575381 Ang angiogenin, ribonuclease, RNase A family, 5 2 3
MIRT575675 Map1b microtubule-associated protein 1B 2 2
MIRT576902 Poteg POTE ankyrin domain family, member G 2 2
MIRT607049 IDS iduronate 2-sulfatase 2 2
MIRT607067 POM121L7 POM121 transmembrane nucleoporin like 7 pseudogene 2 2
MIRT607492 HEBP2 heme binding protein 2 2 2
MIRT607524 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT607657 BTN3A2 butyrophilin subfamily 3 member A2 2 2
MIRT607797 RHBDL2 rhomboid like 2 2 2
MIRT607844 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT607931 ANG angiogenin 2 3
MIRT607968 SNX22 sorting nexin 22 2 2
MIRT608076 ZFP14 ZFP14 zinc finger protein 2 2
MIRT608100 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 2
MIRT608143 SYAP1 synapse associated protein 1 2 2
MIRT608905 ZNF790 zinc finger protein 790 2 2
MIRT612930 GPRIN3 GPRIN family member 3 2 2
MIRT616768 LONP2 lon peptidase 2, peroxisomal 2 2
MIRT617446 CCS copper chaperone for superoxide dismutase 2 2
MIRT617554 MTO1 mitochondrial tRNA translation optimization 1 2 2
MIRT618774 HLA-E major histocompatibility complex, class I, E 2 2
MIRT618928 MEAF6 MYST/Esa1 associated factor 6 2 2
MIRT619248 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT620572 WBSCR27 methyltransferase like 27 2 4
MIRT622655 POU2F3 POU class 2 homeobox 3 2 4
MIRT623175 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT624167 DGKE diacylglycerol kinase epsilon 2 2
MIRT625270 AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 2 2
MIRT625398 AKR7L aldo-keto reductase family 7 like (gene/pseudogene) 2 2
MIRT625696 OPTN optineurin 2 2
MIRT626095 MKLN1 muskelin 1 2 2
MIRT626433 CHDH choline dehydrogenase 2 2
MIRT627015 FIG4 FIG4 phosphoinositide 5-phosphatase 2 2
MIRT627079 SF3A1 splicing factor 3a subunit 1 2 2
MIRT627142 HS3ST1 heparan sulfate-glucosamine 3-sulfotransferase 1 2 2
MIRT627349 TSHZ2 teashirt zinc finger homeobox 2 2 2
MIRT627422 THAP2 THAP domain containing 2 2 2
MIRT627443 TAS2R5 taste 2 receptor member 5 2 2
MIRT627882 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT628080 KAT7 lysine acetyltransferase 7 2 4
MIRT628278 CYB5D1 cytochrome b5 domain containing 1 2 2
MIRT629096 F2RL1 F2R like trypsin receptor 1 2 2
MIRT629238 CINP cyclin dependent kinase 2 interacting protein 2 2
MIRT629288 UNC13A unc-13 homolog A 2 2
MIRT629409 ADM2 adrenomedullin 2 2 2
MIRT629586 RFC2 replication factor C subunit 2 2 2
MIRT629637 WDR31 WD repeat domain 31 2 2
MIRT629876 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT629986 NARS asparaginyl-tRNA synthetase 2 2
MIRT630045 TERF2 telomeric repeat binding factor 2 2 2
MIRT630063 NIP7 NIP7, nucleolar pre-rRNA processing protein 2 2
MIRT630129 ARHGEF5 Rho guanine nucleotide exchange factor 5 2 2
MIRT630157 ZBTB8A zinc finger and BTB domain containing 8A 2 2
MIRT630254 SMTNL2 smoothelin like 2 2 2
MIRT630280 PSMB5 proteasome subunit beta 5 2 2
MIRT630349 NKAP NFKB activating protein 2 2
MIRT630499 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT630554 ROBO1 roundabout guidance receptor 1 2 4
MIRT631266 CENPM centromere protein M 2 2
MIRT631405 IL2RA interleukin 2 receptor subunit alpha 2 2
MIRT632472 RPS15A ribosomal protein S15a 2 2
MIRT632513 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT632598 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT632996 DUSP18 dual specificity phosphatase 18 2 2
MIRT633084 CXorf21 chromosome X open reading frame 21 2 2
MIRT633241 ZNF573 zinc finger protein 573 2 2
MIRT633538 PGBD5 piggyBac transposable element derived 5 2 2
MIRT634340 SGOL1 shugoshin 1 2 2
MIRT634602 KIAA1919 major facilitator superfamily domain containing 4B 2 2
MIRT635052 MYH11 myosin heavy chain 11 2 2
MIRT635106 MAVS mitochondrial antiviral signaling protein 2 2
MIRT635238 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT635324 BMS1 BMS1, ribosome biogenesis factor 2 2
MIRT636270 RNF157 ring finger protein 157 2 2
MIRT636452 LRCH3 leucine rich repeats and calponin homology domain containing 3 2 2
MIRT636518 FMN1 formin 1 2 2
MIRT636655 CDK4 cyclin dependent kinase 4 2 2
MIRT636757 SLC16A5 solute carrier family 16 member 5 2 2
MIRT637136 BAMBI BMP and activin membrane bound inhibitor 2 2
MIRT637190 ROMO1 reactive oxygen species modulator 1 2 2
MIRT637290 IBA57 IBA57 homolog, iron-sulfur cluster assembly 2 2
MIRT637535 RGS9BP regulator of G protein signaling 9 binding protein 2 2
MIRT637695 CEP89 centrosomal protein 89 2 2
MIRT637790 OLA1 Obg like ATPase 1 2 2
MIRT637927 LILRA2 leukocyte immunoglobulin like receptor A2 2 2
MIRT638451 PLXDC2 plexin domain containing 2 2 2
MIRT640674 ARSK arylsulfatase family member K 2 2
MIRT642645 PTGR2 prostaglandin reductase 2 2 2
MIRT643084 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT644238 SLC35E3 solute carrier family 35 member E3 2 2
MIRT644667 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT645094 SLC35E2B solute carrier family 35 member E2B 2 2
MIRT645995 ACP6 acid phosphatase 6, lysophosphatidic 2 2
MIRT646510 FAM217B family with sequence similarity 217 member B 2 2
MIRT647015 ADCY2 adenylate cyclase 2 3 2
MIRT647097 SEC23B Sec23 homolog B, coat complex II component 2 2
MIRT647716 NFX1 nuclear transcription factor, X-box binding 1 2 4
MIRT648042 FADS6 fatty acid desaturase 6 2 2
MIRT648512 PIGG phosphatidylinositol glycan anchor biosynthesis class G 2 2
MIRT648867 ABCA6 ATP binding cassette subfamily A member 6 2 2
MIRT649184 DNPEP aspartyl aminopeptidase 2 2
MIRT649662 TEP1 telomerase associated protein 1 2 2
MIRT651425 YME1L1 YME1 like 1 ATPase 2 2
MIRT651467 XIAP X-linked inhibitor of apoptosis 2 2
MIRT652400 TMEM40 transmembrane protein 40 2 2
MIRT652598 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT653225 SOX17 SRY-box 17 2 2
MIRT653693 SLC25A33 solute carrier family 25 member 33 2 2
MIRT654124 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT656472 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2 2
MIRT658907 DPY19L4 dpy-19 like 4 2 2
MIRT661103 SPIB Spi-B transcription factor 2 2
MIRT661240 ARL17B ADP ribosylation factor like GTPase 17B 2 2
MIRT661293 LIN52 lin-52 DREAM MuvB core complex component 2 2
MIRT662237 PGBD4 piggyBac transposable element derived 4 2 2
MIRT662546 MTAP methylthioadenosine phosphorylase 2 2
MIRT662622 MCM8 minichromosome maintenance 8 homologous recombination repair factor 2 2
MIRT662738 LRRC3C leucine rich repeat containing 3C 2 2
MIRT662846 OMD osteomodulin 2 2
MIRT662909 MED18 mediator complex subunit 18 2 2
MIRT662958 JPH2 junctophilin 2 2 2
MIRT663342 ZNF74 zinc finger protein 74 2 2
MIRT663498 IYD iodotyrosine deiodinase 2 2
MIRT663525 MASTL microtubule associated serine/threonine kinase like 2 2
MIRT663544 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663905 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT663974 ZNF786 zinc finger protein 786 2 2
MIRT664352 C16orf45 chromosome 16 open reading frame 45 2 2
MIRT664419 TIGD6 tigger transposable element derived 6 2 2
MIRT664470 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT664959 PTCD3 pentatricopeptide repeat domain 3 2 2
MIRT664973 TDRD1 tudor domain containing 1 2 2
MIRT665023 ELK1 ELK1, ETS transcription factor 2 2
MIRT665201 ESF1 ESF1 nucleolar pre-rRNA processing protein homolog 2 2
MIRT665361 XKR4 XK related 4 2 2
MIRT665456 WDR17 WD repeat domain 17 2 2
MIRT666080 SSTR2 somatostatin receptor 2 2 2
MIRT666319 SLC16A10 solute carrier family 16 member 10 2 2
MIRT666488 SBNO1 strawberry notch homolog 1 2 2
MIRT666520 RNF170 ring finger protein 170 2 2
MIRT666698 RBM23 RNA binding motif protein 23 2 2
MIRT666764 RAB10 RAB10, member RAS oncogene family 2 2
MIRT667228 NFE2L1 nuclear factor, erythroid 2 like 1 2 2
MIRT667361 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT667476 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT667560 LRAT lecithin retinol acyltransferase 2 2
MIRT667750 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT668090 GMEB1 glucocorticoid modulatory element binding protein 1 2 2
MIRT668121 GK5 glycerol kinase 5 (putative) 2 2
MIRT668168 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT668348 STXBP2 syntaxin binding protein 2 2 2
MIRT668511 ESYT2 extended synaptotagmin 2 2 2
MIRT669293 C17orf85 nuclear cap binding subunit 3 2 2
MIRT669549 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT669780 CNDP1 carnosine dipeptidase 1 2 2
MIRT669860 BROX BRO1 domain and CAAX motif containing 2 4
MIRT670019 TECPR1 tectonin beta-propeller repeat containing 1 2 2
MIRT670179 CCDC142 coiled-coil domain containing 142 2 2
MIRT671109 ZNF841 zinc finger protein 841 2 2
MIRT671353 SMG1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase 2 2
MIRT671478 FLYWCH2 FLYWCH family member 2 2 2
MIRT671494 SLC38A9 solute carrier family 38 member 9 2 2
MIRT671555 LIMS1 LIM zinc finger domain containing 1 2 2
MIRT671670 HEYL hes related family bHLH transcription factor with YRPW motif-like 2 2
MIRT671927 PLEKHS1 pleckstrin homology domain containing S1 2 4
MIRT672198 F2 coagulation factor II, thrombin 2 2
MIRT672219 DCAF7 DDB1 and CUL4 associated factor 7 2 2
MIRT672254 SIK2 salt inducible kinase 2 2 2
MIRT672292 GP2 glycoprotein 2 2 2
MIRT672432 POLR2D RNA polymerase II subunit D 2 2
MIRT672599 NKPD1 NTPase KAP family P-loop domain containing 1 2 2
MIRT672903 KRBA2 KRAB-A domain containing 2 2 2
MIRT672960 ZNF655 zinc finger protein 655 2 2
MIRT673098 SYNPO2L synaptopodin 2 like 2 2
MIRT673174 TMEM56 transmembrane protein 56 2 2
MIRT673253 INO80 INO80 complex subunit 2 2
MIRT673298 RNF19B ring finger protein 19B 2 2
MIRT673577 KDELC2 KDEL motif containing 2 2 2
MIRT673739 TCF23 transcription factor 23 2 2
MIRT674029 ANKRD9 ankyrin repeat domain 9 2 2
MIRT674284 NAGK N-acetylglucosamine kinase 2 2
MIRT674340 KCMF1 potassium channel modulatory factor 1 2 2
MIRT674395 MYCBP MYC binding protein 2 2
MIRT674521 PRR23A proline rich 23A 2 2
MIRT675146 MOGAT1 monoacylglycerol O-acyltransferase 1 2 4
MIRT676027 C9orf69 transmembrane protein 250 2 2
MIRT676432 PLEKHM3 pleckstrin homology domain containing M3 2 2
MIRT676598 ARIH2OS ariadne RBR E3 ubiquitin protein ligase 2 opposite strand 2 2
MIRT678757 ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 2 2
MIRT680346 ZNF281 zinc finger protein 281 2 2
MIRT680469 C3 complement C3 2 2
MIRT682828 FLG2 filaggrin family member 2 2 2
MIRT682883 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT684406 TMEM180 major facilitator superfamily domain containing 13A 2 2
MIRT685277 KIAA1143 KIAA1143 2 2
MIRT686063 KCNA7 potassium voltage-gated channel subfamily A member 7 2 2
MIRT693892 C3orf62 chromosome 3 open reading frame 62 2 2
MIRT699344 SLC35E1 solute carrier family 35 member E1 2 2
MIRT699911 RUNDC1 RUN domain containing 1 2 2
MIRT700809 PHLDA2 pleckstrin homology like domain family A member 2 2 2
MIRT701809 MRPS25 mitochondrial ribosomal protein S25 2 2
MIRT702176 LYRM4 LYR motif containing 4 2 2
MIRT702297 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT704064 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT706209 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT706631 PNPT1 polyribonucleotide nucleotidyltransferase 1 2 2
MIRT706662 RNF216 ring finger protein 216 2 2
MIRT706684 COL13A1 collagen type XIII alpha 1 chain 2 2
MIRT706707 GPR155 G protein-coupled receptor 155 2 2
MIRT706779 ANKRD36 ankyrin repeat domain 36 2 2
MIRT706846 DNAJB13 DnaJ heat shock protein family (Hsp40) member B13 2 2
MIRT706865 MAFF MAF bZIP transcription factor F 2 2
MIRT706898 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT706919 THAP6 THAP domain containing 6 2 2
MIRT706964 FANCC Fanconi anemia complementation group C 2 2
MIRT706982 XPO5 exportin 5 2 2
MIRT707017 RRP36 ribosomal RNA processing 36 2 2
MIRT707034 ACTR5 ARP5 actin related protein 5 homolog 2 2
MIRT707074 MED29 mediator complex subunit 29 2 2
MIRT709370 SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 2 2
MIRT709584 ITPA inosine triphosphatase 2 2
MIRT709692 CUBN cubilin 2 2
MIRT711485 GDF7 growth differentiation factor 7 2 2
MIRT713577 SLC2A8 solute carrier family 2 member 8 2 2
MIRT722798 ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 2 3
MIRT724200 MED7 mediator complex subunit 7 2 2
MIRT736146 GRB2 growth factor receptor bound protein 2 1 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-31 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray Pancreatic Cancer MiaPACA-2 cells 19407485 2009 up-regulated
miR-31 5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) NULL NULL Microarray Pancreatic Cancer MiaPACA-2 cells 19407485 2009 up-regulated
miR-31 Trichostatin A (TSA) NULL 444732 Microarray Pancreatic Cancer MiaPACA-2 cells 19407485 2009 up-regulated
miR-31 5-Fluorouracil approved 3385 Microarray HCT-116 colon cancer cell line 19956872 2010 down-regulated
miR-31 Ginsenoside Rh2 NULL 119307 Microarray NSCLC cell line A549 23152132 2013 down-regulated
miR-31 Doxorubicin approved 31703 Microarray heart 22859947 2012 up-regulated
miR-31 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Quantitative real-time PCR thymus 23024791 2012 down-regulated
miR-31 Tamoxifen approved 2733526 Microarray rat liver 17343880 2007 up-regulated
miR-31 Budesonide approved 5281004 Microarray neonatal mice liver 20145010 2010 down-regulated
miR-31 Phenethyl isothiocyanate(PEITC) NULL 16741 Microarray neonatal mice liver 20145010 2010 down-regulated
miR-31 Leptin NULL NULL Quantitative real-time PCR muscles 20800581 2010 up-regulated
miR-31 Cocaine NULL 446220 Next-generation sequencing ventral striatum 21708909 2011 down-regulated
miR-31 Longevinex NULL NULL Quantitative real-time PCR ischemia/reperfusion [I/R] rat model 21203465 2011 down-regulated
miR-31 Longevinex NULL NULL Quantitative real-time PCR normal heart 21203465 2011 up-regulated
miR-31 Resveratrol NULL 445154 Quantitative real-time PCR ischemia/reperfusion [I/R] rat model 21203465 2011 down-regulated
miR-31 Resveratrol NULL 445154 Quantitative real-time PCR normal heart 21203465 2011 up-regulated
miR-31 Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 up-regulated
miR-31 Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-31 Calcium sulfate (CaS) NULL 24497 Microarray MG63E osteoblast-like cells 17618507 2008 down-regulated
miR-31 Valproate approved 3121 Quantitative real-time PCR CD4+, CD25- T cells 20427269 2010 down-regulated
miR-31 Enoxacin approved 3229 Quantitative real-time PCR HCT-116 and RKO colon cancer cell lines 21368194 2011 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-31 Tamoxifen 2733525 NSC180973 approved sensitive Low Breast Cancer cell line (MCF-7, T47D)
hsa-mir-31 Sorafenib 216239 NSC747971 approved resistant High Hepatocellular Carcinoma cell line (HepG2, SK-HEP-1)
hsa-mir-31 Cisplatin 5460033 NSC119875 approved sensitive High Lung Adenocarcinoma cell line (A549)
hsa-mir-31 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-31 Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-mir-31 Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-mir-31 Paclitaxel 36314 NSC125973 approved sensitive cell line (W1)
hsa-mir-31 Cisplatin 5460033 NSC119875 approved sensitive cell line (W1)
hsa-mir-31 Methotrexate 126941 NSC740 approved sensitive cell line (W1)
hsa-mir-31 Topotecan 60699 NSC609699 approved sensitive cell line (W1)
hsa-mir-31 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-mir-31 Androstenedione 6128 NSC9563 resistant cell line (MCF-7)
hsa-mir-31 Androstenedione+Anastrozole resistant cell line (MCF-7)
hsa-mir-31 Cisplatin 5460033 NSC119875 approved resistant cell line (KYSE)
hsa-mir-31 Tamoxifen 2733525 NSC180973 approved sensitive cell line (MCF7)
hsa-mir-3135b Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-3135b Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-3135b Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-3135b Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-3135b Gefitinib 123631 NSC715055 approved sensitive High Non-Small Cell Lung Cancer cell line (PC-9)
hsa-miR-3135b Fluorouracil 3385 NSC19893 approved sensitive High Colorectal Cancer cell line (HT-29)
hsa-miR-3135b Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (AsPC-1)
hsa-miR-3135b Paclitaxel 36314 NSC125973 approved resistant High Endometrial Serous Carcinoma cell line (USPC1)
hsa-mir-3135b Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-3135b Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-mir-3135b Topotecan 60699 NSC609699 approved resistant cell line (W1)
hsa-mir-3135b Androstenedione 6128 NSC9563 resistant cell line (MCF-7)
hsa-mir-3135b Androstenedione+Letrozole resistant cell line (MCF-7)
hsa-mir-3135b Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-3135b Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-3135b Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (cytosolic RNA)
hsa-miR-3135b Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (mitochondrial RNA)
hsa-miR-3135b Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-miR-3135b Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-3135b Tamoxifen+Fulvestrant resistant cell line (LCC9)
hsa-miR-3135b Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-3135b Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-3135b Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-3135b Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)

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