miRTarBase - #MIRT477716


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pre-miRNA Information
pre-miRNA hsa-mir-4776-1   
Genomic Coordinates chr2: 212926257 - 212926336
Description Homo sapiens miR-4776-1 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-4776-2   
Genomic Coordinates chr2: 212926257 - 212926336
Description Homo sapiens miR-4776-2 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4776-3p
Sequence 54| CUUGCCAUCCUGGUCCACUGCAU |76
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1350638372 1 dbSNP
rs1220781023 5 dbSNP
rs1269946481 7 dbSNP
rs547466728 10 dbSNP
rs965980067 11 dbSNP
rs953060487 13 dbSNP
rs982906747 14 dbSNP
rs1028686150 21 dbSNP
rs951447113 23 dbSNP
Putative Targets

Gene Information
Gene Symbol EEF1A1   
Synonyms CCS-3, CCS3, EE1A1, EEF-1, EEF1A, EF-Tu, EF1A, GRAF-1EF, HNGC:16303, LENG7, PTI1, eEF1A-1
Description eukaryotic translation elongation factor 1 alpha 1
Transcript NM_001402   
Expression
Putative miRNA Targets on EEF1A1
3'UTR of EEF1A1
(miRNA target sites are highlighted)		 
>EEF1A1|NM_001402|3'UTR
   1 ATATTATCCCTAATACCTGCCACCCCACTCTTAATCAGTGGTGGAAGAACGGTCTCAGAACTGTTTGTTTCAATTGGCCA
  81 TTTAAGTTTAGTAGTAAAAGACTGGTTAATGATAACAATGCATCGTAAAACCTTCAGAAGGAAAGGAGAATGTTTTGTGG
 161 ACCACTTTGGTTTTCTTTTTTGCGTGTGGCAGTTTTAAGTTATTAGTTTTTAAAATCAGTACTTTTTAATGGAAACAACT
 241 TGACCAAAAATTTGTCACAGAATTTTGAGACCCATTAAAAAAGTTAAATGAGAAACCTGTGTGTTCCTTTGGTCAACACC
 321 GAGACATTTAGGTGAAAGACATCTAATTCTGGTTTTACGAATCTGGAAACTTCTTGAAAATGTAATTCTTGAGTTAACAC
 401 TTCTGGGTGGAGAATAGGGTTGTTTTCCCCCCACATAATTGGAAGGGGAAGGAATATCATTTAAAGCTATGGGAGGGTTG
 481 CTTTGATTACAACACTGGAGAGAAATGCAGCATGTTGCTGATTGCCTGTCACTAAAACAGGCCAAAAACTGAGTCCTTGT
 561 GTTGCATAGAAAGCTTCATGTTGCTAAACCAATGTTAAGTGAATCTTTGGAAACAAAATGTTTCCAAATTACTGGGATGT
 641 GCATGTTGAAACGTGGGTTAAAATGACTGGGCAGTGAAAGTTGACTATTTGCCATGACATAAGAAATAAGTGTAGTGGCT
 721 AGTGTACACCCTATGAGTGGAAGGGTCCATTTTGAAGTCAGTGGAGTAAGCTTTATGCCAGTTTGATGGTTTCACAAGTT
 801 CTATTGAGTGCTATTCAGAATAGGAACAAGGTTCTAATAGAAAAAGATGGCAATTTGAAGTAGCTATAAAATTAGACTAA
 881 TCTACATTGCTTTTCTCCTGCAGAGTCTAATACCTTTTATGCTTTGATAATTAGCAGTTTGTCTACTTGGTCACTAGGAA
 961 TGAAACTACATGGTAATAGGCTTAACAGGTGTAATAGCCCACTTACTCCTGAATCTTTAAGCATTTGTGCATTTGAAAAA
1041 TGCTTTTCGCGATCTTCCTGCTGGGATTACAGGCATGAGCCACTGTGCCTGACCTCCCATATGTAAAAGTGTCTAAAGGT
1121 TTTTTTTTGGTTATAAAAGGAAAATTTTTGCTTAAGTTTGAAGGATAGGTAAAATTAAAGGACATGCTTTCTGTTTGTGT
1201 GATGGTTTTTAAAAATTTTTTTTAAGATGGAGTTCTTGTTGCCCAGGCTAGAATGCAATGGCAAAATCTCACTGCAATCT
1281 CCTCCTCCTGGGTTCAAGCAATTCTCCTACTTCAGCCTCCCAAGTAGCTGGGATTACAGGCATGTGCTAATTTGGTGTTT
1361 TTAATAGAGATGAGGTTTTTCCATGTTGGTCAGGCTGGTCTCAAACTCCTGACCTTAGGTGATCGCCTCGGCCTCCTAAA
1441 GTGCTGGAATTACAGGCATGAGCCACCATGCCTGGCCAGGACATGTGTTCTTAAGGACATGCTAAGCAGGAGTTAAAGCA
1521 GCCCAAGAGATAAGGCCTCTTAAAGTGACTGGCAATGTGTATTGCTCAAGATTCAAAGGTACTTGAATTGGCCATAGACA
1601 AGTCTGTAATGAAGTGTTATCGTTTTCCCTCATCTGAGTCTGAATTAGATAAAATGCCTTCCCATCAGCCAGTGCTCTGA
1681 GGTATCAAGTCTAAATTGAACTAGAGATTTTTGTCCTTAGTTTCTTTGCTATCTAATGTTTACACAAGTAAATAGTCTAA
1761 GATTTGCTGGATGACAGAAAAAACAGGTAAGGCCTTTAATAGATGGCCAATAGATGCCCTGATAATGAAAGTTGACACCT
1841 GTAAGATTTACCAGTAGAGAATTCTTGACATGCAAGGAAGCAAGATTTAACTGAAAAATTGTTCCCACTGGAAGCAGGAA
1921 TGAGTCAGTTTACTTGCATATACTGAGATTGAGATTAACTTCCTGTGAAACCCAGTGTCTTAGACAACTGTGGCTTGAGC
2001 ACCACCTGCTGGTATTCATTACAAACTTGCTCACTACAATAAATGAATTTTAAGCTTTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uacGUCACCUGGUCCUACCGUUc 5'
             :| | ||  | |||||||| 
Target 5' ttcTAATAGAAAAAGATGGCAAt 3'
 832 - 854 156.00 -9.90
2 
miRNA  3' uacGUC--ACCUGGUCCUACCGUUc 5'
             |||  | || ::  ||||||| 
Target 5' gccCAGGCTAGAATGCAATGGCAAa 3'
 1241 - 1265 150.00 -12.70
3 
miRNA  3' uaCGUCACCUGGUCCUACCGUUc 5'
            | | || | |   ||||:|| 
Target 5' taGGAATGAAACTACATGGTAAt 3'
 955 - 977 133.00 -5.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30146135 14 COSMIC
COSN31574594 47 COSMIC
COSN31549673 52 COSMIC
COSN23980113 207 COSMIC
COSN8514733 256 COSMIC
COSN32057273 286 COSMIC
COSN31778537 306 COSMIC
COSN9806531 369 COSMIC
COSN15993337 485 COSMIC
COSN26400868 500 COSMIC
COSN16613821 599 COSMIC
COSN7795032 618 COSMIC
COSN7897149 636 COSMIC
COSN27996285 781 COSMIC
COSN4928988 891 COSMIC
COSN194510 1073 COSMIC
COSN29594940 1119 COSMIC
COSN32056152 1169 COSMIC
COSN31778518 1182 COSMIC
COSN20916956 1329 COSMIC
COSN4957793 1679 COSMIC
COSN9912885 1731 COSMIC
COSN22819845 1777 COSMIC
COSN18951580 1827 COSMIC
COSN20543711 1864 COSMIC
COSN2176589 1875 COSMIC
COSN23319476 1957 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1390193007 2 dbSNP
rs771971121 4 dbSNP
rs745637124 7 dbSNP
rs778191996 8 dbSNP
rs1391862277 9 dbSNP
rs756372821 10 dbSNP
rs1169415474 12 dbSNP
rs752926143 14 dbSNP
rs201959385 16 dbSNP
rs755049275 17 dbSNP
rs1476907194 26 dbSNP
rs752107734 27 dbSNP
rs766787655 31 dbSNP
rs1340420021 35 dbSNP
rs1430579261 37 dbSNP
rs763430850 43 dbSNP
rs1436667686 49 dbSNP
rs549190139 50 dbSNP
rs761478115 51 dbSNP
rs776212621 56 dbSNP
rs1462122066 57 dbSNP
rs768163263 62 dbSNP
rs1249837685 66 dbSNP
rs1474358909 70 dbSNP
rs771326628 71 dbSNP
rs1185753813 80 dbSNP
rs1165240071 81 dbSNP
rs1425576674 86 dbSNP
rs1434599469 89 dbSNP
rs1404815669 97 dbSNP
rs1488803930 97 dbSNP
rs1457322498 100 dbSNP
rs1321911644 103 dbSNP
rs1347494408 108 dbSNP
rs1265743548 110 dbSNP
rs1429203763 114 dbSNP
rs1368733902 116 dbSNP
rs1225652963 117 dbSNP
rs1281624243 121 dbSNP
rs1218363024 125 dbSNP
rs1323030717 133 dbSNP
rs1209469094 146 dbSNP
rs1270051617 147 dbSNP
rs1445257655 147 dbSNP
rs1214963804 149 dbSNP
rs1247132363 150 dbSNP
rs531007027 153 dbSNP
rs369399951 154 dbSNP
rs774576782 157 dbSNP
rs1196944805 161 dbSNP
rs1428190747 164 dbSNP
rs1472690118 165 dbSNP
rs1160797269 169 dbSNP
rs1405135414 170 dbSNP
rs1399528259 175 dbSNP
rs1487069616 178 dbSNP
rs1282941776 182 dbSNP
rs1350911145 182 dbSNP
rs1200525172 183 dbSNP
rs1301627889 184 dbSNP
rs1345153832 192 dbSNP
rs570171124 195 dbSNP
rs1229217912 197 dbSNP
rs1281402139 197 dbSNP
rs1348618810 201 dbSNP
rs1223221170 202 dbSNP
rs1290523059 203 dbSNP
rs1453205701 205 dbSNP
rs1220012883 206 dbSNP
rs1267878321 209 dbSNP
rs1347104020 215 dbSNP
rs113013917 216 dbSNP
rs1222783652 221 dbSNP
rs11550855 224 dbSNP
rs185622540 230 dbSNP
rs1279795726 233 dbSNP
rs948784097 238 dbSNP
rs1007128382 242 dbSNP
rs1398392023 242 dbSNP
rs11558344 246 dbSNP
rs1415190327 250 dbSNP
rs1360127428 252 dbSNP
rs1162112269 254 dbSNP
rs756151811 258 dbSNP
rs1410735054 259 dbSNP
rs1416219840 272 dbSNP
rs879011242 274 dbSNP
rs1334145624 277 dbSNP
rs1284811814 283 dbSNP
rs889938086 283 dbSNP
rs1361552031 285 dbSNP
rs560084399 287 dbSNP
rs1243654803 290 dbSNP
rs1197263999 296 dbSNP
rs1290839805 296 dbSNP
rs1342603213 296 dbSNP
rs541067582 299 dbSNP
rs1436819798 305 dbSNP
rs528878907 305 dbSNP
rs1238673130 306 dbSNP
rs769050982 313 dbSNP
rs998323426 320 dbSNP
rs891842763 321 dbSNP
rs1191866120 324 dbSNP
rs1476671686 327 dbSNP
rs953933527 329 dbSNP
rs115224400 331 dbSNP
rs1187693721 332 dbSNP
rs372200470 334 dbSNP
rs965057485 336 dbSNP
rs1275836256 337 dbSNP
rs1450447584 340 dbSNP
rs1202976591 347 dbSNP
rs1318428669 349 dbSNP
rs1044692131 352 dbSNP
rs1015198828 358 dbSNP
rs1004548508 359 dbSNP
rs192629107 360 dbSNP
rs952635287 363 dbSNP
rs1027234777 373 dbSNP
rs1002008690 374 dbSNP
rs1264529962 376 dbSNP
rs1459593608 378 dbSNP
rs929130848 380 dbSNP
rs1243094822 390 dbSNP
rs139915867 391 dbSNP
rs780493244 396 dbSNP
rs905018486 396 dbSNP
rs866235348 400 dbSNP
rs918962783 402 dbSNP
rs1014329590 403 dbSNP
rs1173375359 404 dbSNP
rs187523336 407 dbSNP
rs1468311422 415 dbSNP
rs910245851 421 dbSNP
rs985657978 422 dbSNP
rs557676047 426 dbSNP
rs545545535 427 dbSNP
rs1053098525 431 dbSNP
rs1325633090 433 dbSNP
rs879551928 433 dbSNP
rs998272433 435 dbSNP
rs956272271 438 dbSNP
rs1466602814 450 dbSNP
rs1202518611 454 dbSNP
rs1403076964 457 dbSNP
rs934926754 460 dbSNP
rs1268173458 461 dbSNP
rs1486506786 465 dbSNP
rs1169057083 466 dbSNP
rs572051508 468 dbSNP
rs1000315082 469 dbSNP
rs1446793632 472 dbSNP
rs1200525952 477 dbSNP
rs1043626788 478 dbSNP
rs9442917 480 dbSNP
rs1479558454 488 dbSNP
rs112358938 496 dbSNP
rs976497102 504 dbSNP
rs1287050022 505 dbSNP
rs1235249435 506 dbSNP
rs895701842 509 dbSNP
rs1057074318 510 dbSNP
rs965068515 511 dbSNP
rs908233372 517 dbSNP
rs1343297506 522 dbSNP
rs114626730 523 dbSNP
rs952745542 524 dbSNP
rs919128770 532 dbSNP
rs1458205733 536 dbSNP
rs1026937904 544 dbSNP
rs555698355 545 dbSNP
rs137968211 551 dbSNP
rs1491381260 552 dbSNP
rs1271460397 554 dbSNP
rs1489936313 557 dbSNP
rs1198954884 559 dbSNP
rs16883805 560 dbSNP
rs922856990 561 dbSNP
rs1354423129 567 dbSNP
rs1363185843 568 dbSNP
rs1425186103 574 dbSNP
rs1165289217 575 dbSNP
rs1314533719 576 dbSNP
rs977006773 584 dbSNP
rs115756680 585 dbSNP
rs1014362067 589 dbSNP
rs1379822301 589 dbSNP
rs147292801 591 dbSNP
rs1031862978 592 dbSNP
rs1000790827 593 dbSNP
rs780798661 595 dbSNP
rs1294484150 597 dbSNP
rs998837177 599 dbSNP
rs904507930 603 dbSNP
rs1167270606 605 dbSNP
rs1175594538 610 dbSNP
rs1043335488 612 dbSNP
rs533556344 614 dbSNP
rs1249880979 615 dbSNP
rs900021218 616 dbSNP
rs1445225704 618 dbSNP
rs1383231934 619 dbSNP
rs1406803940 619 dbSNP
rs566409747 623 dbSNP
rs1012882788 624 dbSNP
rs1170824443 627 dbSNP
rs1355950853 633 dbSNP
rs1041158963 636 dbSNP
rs943809814 638 dbSNP
rs1439743006 639 dbSNP
rs867069756 642 dbSNP
rs1381582594 643 dbSNP
rs114175855 652 dbSNP
rs1381156847 652 dbSNP
rs529563428 653 dbSNP
rs1309536407 656 dbSNP
rs919583398 657 dbSNP
rs1461829793 661 dbSNP
rs897633833 663 dbSNP
rs1443888849 665 dbSNP
rs980718877 666 dbSNP
rs13193159 668 dbSNP
rs1291284550 670 dbSNP
rs752366806 670 dbSNP
rs1024815516 673 dbSNP
rs1241098970 675 dbSNP
rs765093620 677 dbSNP
rs991968122 678 dbSNP
rs184611265 679 dbSNP
rs1470680770 685 dbSNP
rs1334068178 687 dbSNP
rs531309435 691 dbSNP
rs1346518230 693 dbSNP
rs1289876780 694 dbSNP
rs1307109153 696 dbSNP
rs1364518052 698 dbSNP
rs1223723333 699 dbSNP
rs1050174252 700 dbSNP
rs1225466389 705 dbSNP
rs1261304298 706 dbSNP
rs1031782723 707 dbSNP
rs564201050 709 dbSNP
rs1455698714 710 dbSNP
rs1484775324 710 dbSNP
rs922969580 710 dbSNP
rs1481194333 714 dbSNP
rs149215139 714 dbSNP
rs999325497 715 dbSNP
rs192668234 717 dbSNP
rs1022012661 719 dbSNP
rs934906252 722 dbSNP
rs1467250708 723 dbSNP
rs755979222 724 dbSNP
rs924869005 725 dbSNP
rs1297929700 727 dbSNP
rs997059546 731 dbSNP
rs759306421 737 dbSNP
rs978918203 738 dbSNP
rs144143413 739 dbSNP
rs1381638936 744 dbSNP
rs1156232190 746 dbSNP
rs753796101 747 dbSNP
rs559888220 748 dbSNP
rs1046849952 758 dbSNP
rs187330951 760 dbSNP
rs1490754346 763 dbSNP
rs1196830501 766 dbSNP
rs1476899154 767 dbSNP
rs1267649361 768 dbSNP
rs1470210265 769 dbSNP
rs1035715002 771 dbSNP
rs1410843333 772 dbSNP
rs1399433955 774 dbSNP
rs1158474940 780 dbSNP
rs1366571396 788 dbSNP
rs1426868313 789 dbSNP
rs1267860289 790 dbSNP
rs1301534694 791 dbSNP
rs1330688979 796 dbSNP
rs919609341 797 dbSNP
rs1281318845 800 dbSNP
rs533254434 801 dbSNP
rs980393686 803 dbSNP
rs566086561 804 dbSNP
rs917810613 805 dbSNP
rs1361332769 806 dbSNP
rs897708806 807 dbSNP
rs1290609538 808 dbSNP
rs992061815 815 dbSNP
rs1006052939 818 dbSNP
rs570141088 824 dbSNP
rs1318346272 830 dbSNP
rs1050122092 834 dbSNP
rs1031247050 836 dbSNP
rs138533046 838 dbSNP
rs867945398 842 dbSNP
rs901619474 843 dbSNP
rs772877932 846 dbSNP
rs934998247 848 dbSNP
rs1352831965 850 dbSNP
rs1446042561 853 dbSNP
rs1315659719 857 dbSNP
rs1384842382 859 dbSNP
rs1304015104 861 dbSNP
rs1283352127 862 dbSNP
rs41501347 866 dbSNP
rs979462905 873 dbSNP
rs1270356899 880 dbSNP
rs964001774 881 dbSNP
rs1279171948 886 dbSNP
rs1456936848 886 dbSNP
rs1203687172 888 dbSNP
rs1422688277 889 dbSNP
rs947528828 895 dbSNP
rs1182180287 897 dbSNP
rs916108465 898 dbSNP
rs991550380 899 dbSNP
rs147103543 902 dbSNP
rs1008432473 908 dbSNP
rs1337425667 909 dbSNP
rs1408262554 909 dbSNP
rs1450330737 909 dbSNP
rs1326803583 911 dbSNP
rs887317681 911 dbSNP
rs1047640329 913 dbSNP
rs1229255483 913 dbSNP
rs1491384588 918 dbSNP
rs1491214132 919 dbSNP
rs972053008 919 dbSNP
rs1463092355 923 dbSNP
rs777395757 926 dbSNP
rs995269632 927 dbSNP
rs898215396 930 dbSNP
rs1468116769 942 dbSNP
rs764348024 947 dbSNP
rs1428348488 951 dbSNP
rs962395432 952 dbSNP
rs1478958703 956 dbSNP
rs540064883 958 dbSNP
rs1016176506 962 dbSNP
rs1177307204 967 dbSNP
rs1006580124 969 dbSNP
rs1044763923 970 dbSNP
rs1468230433 974 dbSNP
rs761537241 975 dbSNP
rs1385511143 976 dbSNP
rs141416343 977 dbSNP
rs1315919895 978 dbSNP
rs1339491409 979 dbSNP
rs1257783878 980 dbSNP
rs1405162159 981 dbSNP
rs1284721065 984 dbSNP
rs182862632 986 dbSNP
rs917568694 987 dbSNP
rs535782447 988 dbSNP
rs1255943415 991 dbSNP
rs190673282 997 dbSNP
rs923802948 998 dbSNP
rs769055764 1006 dbSNP
rs979653386 1008 dbSNP
rs1220833237 1009 dbSNP
rs374691946 1014 dbSNP
rs1271237005 1016 dbSNP
rs1342037981 1018 dbSNP
rs1431527585 1019 dbSNP
rs549557322 1020 dbSNP
rs975451894 1022 dbSNP
rs531321585 1029 dbSNP
rs550342569 1031 dbSNP
rs964054061 1037 dbSNP
rs1304592648 1038 dbSNP
rs1343200769 1039 dbSNP
rs1043301018 1042 dbSNP
rs1307047617 1043 dbSNP
rs1334611319 1044 dbSNP
rs370282121 1048 dbSNP
rs187745352 1049 dbSNP
rs951676173 1050 dbSNP
rs377387975 1051 dbSNP
rs1025830075 1052 dbSNP
rs996049923 1058 dbSNP
rs1417330652 1059 dbSNP
rs1180585452 1060 dbSNP
rs972592735 1060 dbSNP
rs898649300 1061 dbSNP
rs962057677 1065 dbSNP
rs35521951 1066 dbSNP
rs1367805752 1067 dbSNP
rs1371091313 1069 dbSNP
rs909231062 1072 dbSNP
rs1394973940 1075 dbSNP
rs376297133 1080 dbSNP
rs984776114 1084 dbSNP
rs1011998714 1087 dbSNP
rs953269504 1089 dbSNP
rs896186044 1093 dbSNP
rs1312497641 1098 dbSNP
rs1028876346 1101 dbSNP
rs1258355714 1103 dbSNP
rs1222040362 1109 dbSNP
rs1250618819 1109 dbSNP
rs1181821642 1113 dbSNP
rs1056106109 1114 dbSNP
rs1238836720 1115 dbSNP
rs1460954497 1115 dbSNP
rs1181926227 1118 dbSNP
rs528396258 1118 dbSNP
rs1239293605 1120 dbSNP
rs923827262 1121 dbSNP
rs143297587 1122 dbSNP
rs867650994 1123 dbSNP
rs1467621381 1128 dbSNP
rs1332672863 1129 dbSNP
rs527351503 1129 dbSNP
rs903500536 1129 dbSNP
rs371281509 1131 dbSNP
rs1011931484 1135 dbSNP
rs1380889667 1136 dbSNP
rs921767068 1137 dbSNP
rs1294560286 1139 dbSNP
rs1431096744 1141 dbSNP
rs975504146 1142 dbSNP
rs1226249117 1144 dbSNP
rs964063481 1146 dbSNP
rs1220351046 1150 dbSNP
rs559927403 1150 dbSNP
rs1321948127 1151 dbSNP
rs1314330288 1154 dbSNP
rs78631420 1158 dbSNP
rs1483692680 1163 dbSNP
rs541580152 1165 dbSNP
rs574692065 1166 dbSNP
rs1260047155 1167 dbSNP
rs1331996408 1168 dbSNP
rs113414349 1169 dbSNP
rs1429211388 1173 dbSNP
rs11755449 1180 dbSNP
rs1173332777 1181 dbSNP
rs576361374 1183 dbSNP
rs1360442182 1184 dbSNP
rs1036429967 1187 dbSNP
rs1458664163 1193 dbSNP
rs940749696 1193 dbSNP
rs558153819 1195 dbSNP
rs1161801720 1196 dbSNP
rs1278688274 1198 dbSNP
rs1322725946 1199 dbSNP
rs757979528 1202 dbSNP
rs1221674093 1210 dbSNP
rs539952985 1211 dbSNP
rs984723662 1214 dbSNP
rs1390082 1215 dbSNP
rs921848292 1216 dbSNP
rs1489440099 1217 dbSNP
rs559126325 1218 dbSNP
rs1436513296 1219 dbSNP
rs1479731841 1220 dbSNP
rs1241612067 1224 dbSNP
rs201407046 1224 dbSNP
rs1414567565 1227 dbSNP
rs1210799423 1231 dbSNP
rs1157843504 1232 dbSNP
rs962909370 1238 dbSNP
rs1421211290 1242 dbSNP
rs777190841 1242 dbSNP
rs1298568081 1246 dbSNP
rs554409799 1247 dbSNP
rs1023799037 1248 dbSNP
rs1293452945 1249 dbSNP
rs1243272987 1250 dbSNP
rs1358137770 1253 dbSNP
rs965890768 1255 dbSNP
rs1368332185 1258 dbSNP
rs1223302078 1260 dbSNP
rs1012008413 1263 dbSNP
rs1305049407 1267 dbSNP
rs1242229338 1270 dbSNP
rs1333901577 1274 dbSNP
rs536043151 1277 dbSNP
rs977970008 1278 dbSNP
rs968173301 1279 dbSNP
rs1022051545 1281 dbSNP
rs1247817249 1283 dbSNP
rs771273374 1285 dbSNP
rs1393192800 1287 dbSNP
rs1128073 1288 dbSNP
rs376238730 1290 dbSNP
rs183965550 1296 dbSNP
rs1361258765 1298 dbSNP
rs1003150641 1301 dbSNP
rs1364687909 1304 dbSNP
rs1036911111 1309 dbSNP
rs907473207 1309 dbSNP
rs1160531680 1310 dbSNP
rs902160013 1321 dbSNP
rs1241099024 1324 dbSNP
rs1469109023 1329 dbSNP
rs1363709571 1337 dbSNP
rs1044074925 1340 dbSNP
rs1354620857 1344 dbSNP
rs887822346 1351 dbSNP
rs946647419 1355 dbSNP
rs1200073666 1365 dbSNP
rs900352907 1366 dbSNP
rs1437743596 1372 dbSNP
rs757365721 1374 dbSNP
rs1235794048 1376 dbSNP
rs1038804294 1381 dbSNP
rs1178811476 1382 dbSNP
rs1384235965 1384 dbSNP
rs1471647434 1386 dbSNP
rs931974086 1389 dbSNP
rs942805742 1389 dbSNP
rs1329268342 1396 dbSNP
rs1402491291 1398 dbSNP
rs1447628990 1400 dbSNP
rs1336249887 1406 dbSNP
rs975950960 1422 dbSNP
rs192446229 1424 dbSNP
rs751793537 1425 dbSNP
rs1217293237 1428 dbSNP
rs1319312856 1429 dbSNP
rs923893667 1430 dbSNP
rs777896514 1436 dbSNP
rs986889736 1438 dbSNP
rs570129661 1441 dbSNP
rs929990638 1443 dbSNP
rs545102853 1444 dbSNP
rs577638464 1445 dbSNP
rs1206367428 1447 dbSNP
rs967909437 1453 dbSNP
rs1278846999 1454 dbSNP
rs1233828424 1460 dbSNP
rs1347183632 1464 dbSNP
rs1175784732 1466 dbSNP
rs1400218907 1468 dbSNP
rs974763585 1470 dbSNP
rs1335136777 1472 dbSNP
rs1398552918 1477 dbSNP
rs962918346 1479 dbSNP
rs1022047192 1480 dbSNP
rs1281073897 1481 dbSNP
rs990598450 1482 dbSNP
rs527391186 1483 dbSNP
rs754769888 1485 dbSNP
rs868426159 1486 dbSNP
rs1342306771 1489 dbSNP
rs990960011 1491 dbSNP
rs960854705 1492 dbSNP
rs1015181201 1493 dbSNP
rs77224446 1499 dbSNP
rs1384297124 1502 dbSNP
rs1173697813 1503 dbSNP
rs887983776 1508 dbSNP
rs1198652975 1512 dbSNP
rs1467979137 1513 dbSNP
rs1049119764 1522 dbSNP
rs529881423 1524 dbSNP
rs1384529316 1525 dbSNP
rs1427648061 1528 dbSNP
rs999281947 1529 dbSNP
rs562666593 1530 dbSNP
rs1263427084 1531 dbSNP
rs900613496 1532 dbSNP
rs544515226 1534 dbSNP
rs1282877440 1535 dbSNP
rs1234789794 1537 dbSNP
rs185923006 1543 dbSNP
rs1274998568 1547 dbSNP
rs902211289 1549 dbSNP
rs1352510870 1550 dbSNP
rs552938808 1553 dbSNP
rs1021929023 1555 dbSNP
rs944731778 1556 dbSNP
rs1488512242 1561 dbSNP
rs1209113700 1564 dbSNP
rs77163422 1565 dbSNP
rs1434910976 1566 dbSNP
rs978069918 1573 dbSNP
rs915102254 1574 dbSNP
rs959471743 1574 dbSNP
rs1160716598 1576 dbSNP
rs1222654212 1577 dbSNP
rs1361522690 1580 dbSNP
rs990670491 1581 dbSNP
rs1292227518 1585 dbSNP
rs1393511972 1588 dbSNP
rs756123566 1591 dbSNP
rs1318927168 1593 dbSNP
rs546172016 1598 dbSNP
rs749018166 1599 dbSNP
rs1311025881 1605 dbSNP
rs139487221 1606 dbSNP
rs3832420 1606 dbSNP
rs1334842535 1608 dbSNP
rs1263522729 1611 dbSNP
rs1489412898 1616 dbSNP
rs1217338907 1618 dbSNP
rs1398372976 1619 dbSNP
rs572617510 1620 dbSNP
rs573295095 1621 dbSNP
rs145449215 1622 dbSNP
rs1423527343 1625 dbSNP
rs1163106730 1628 dbSNP
rs1370614345 1631 dbSNP
rs749892556 1631 dbSNP
rs767037567 1632 dbSNP
rs760702169 1633 dbSNP
rs1443953796 1634 dbSNP
rs1332880026 1640 dbSNP
rs1169303028 1651 dbSNP
rs574999371 1656 dbSNP
rs566835215 1657 dbSNP
rs1377173416 1658 dbSNP
rs1474187819 1659 dbSNP
rs1005161034 1660 dbSNP
rs1271268987 1661 dbSNP
rs140448519 1667 dbSNP
rs1245368967 1670 dbSNP
rs774027774 1675 dbSNP
rs181076483 1677 dbSNP
rs1200602822 1687 dbSNP
rs1238931521 1689 dbSNP
rs1483035489 1696 dbSNP
rs763706579 1699 dbSNP
rs1258656191 1706 dbSNP
rs1424780657 1709 dbSNP
rs1193499925 1713 dbSNP
rs1422114853 1716 dbSNP
rs1356912185 1719 dbSNP
rs1467703935 1720 dbSNP
rs974060107 1723 dbSNP
rs1354656062 1724 dbSNP
rs996313810 1725 dbSNP
rs1300746488 1727 dbSNP
rs879009168 1730 dbSNP
rs115452014 1731 dbSNP
rs558179239 1735 dbSNP
rs745777813 1737 dbSNP
rs1277405733 1744 dbSNP
rs1338318622 1745 dbSNP
rs1009309438 1748 dbSNP
rs763257477 1749 dbSNP
rs1311711601 1750 dbSNP
rs1208221556 1752 dbSNP
rs1257995511 1753 dbSNP
rs1202918560 1754 dbSNP
rs1366581927 1755 dbSNP
rs1483744855 1755 dbSNP
rs1318362215 1757 dbSNP
rs1261550375 1758 dbSNP
rs916865356 1758 dbSNP
rs1491092085 1759 dbSNP
rs1419554034 1760 dbSNP
rs1491555523 1760 dbSNP
rs1173438579 1761 dbSNP
rs1360538655 1762 dbSNP
rs991053459 1765 dbSNP
rs1274785558 1769 dbSNP
rs1297332374 1769 dbSNP
rs1358433988 1775 dbSNP
rs1033747143 1776 dbSNP
rs960905216 1778 dbSNP
rs1213034474 1779 dbSNP
rs1366926533 1783 dbSNP
rs946631132 1784 dbSNP
rs928147095 1797 dbSNP
rs185519638 1798 dbSNP
rs1284912890 1805 dbSNP
rs966447708 1810 dbSNP
rs1489491977 1814 dbSNP
rs1217925341 1816 dbSNP
rs927697442 1822 dbSNP
rs1248233081 1831 dbSNP
rs566266273 1832 dbSNP
rs548244542 1839 dbSNP
rs1188941883 1840 dbSNP
rs1010499213 1841 dbSNP
rs1336681308 1859 dbSNP
rs1426721636 1867 dbSNP
rs964333308 1873 dbSNP
rs1454423295 1876 dbSNP
rs1157711376 1883 dbSNP
rs770220875 1884 dbSNP
rs1008765719 1888 dbSNP
rs781215632 1894 dbSNP
rs746389957 1895 dbSNP
rs1421301705 1900 dbSNP
rs908224021 1901 dbSNP
rs1349222221 1902 dbSNP
rs1434290300 1902 dbSNP
rs1047521751 1904 dbSNP
rs994660191 1907 dbSNP
rs1418324779 1920 dbSNP
rs1239640635 1923 dbSNP
rs1307373726 1924 dbSNP
rs1163377348 1925 dbSNP
rs1241324712 1926 dbSNP
rs1445961967 1927 dbSNP
rs376596299 1928 dbSNP
rs1038452920 1929 dbSNP
rs761911720 1929 dbSNP
rs941367245 1937 dbSNP
rs1247906320 1941 dbSNP
rs1468556847 1944 dbSNP
rs964886742 1947 dbSNP
rs1182930848 1948 dbSNP
rs916583700 1949 dbSNP
rs1441232971 1950 dbSNP
rs1158916149 1951 dbSNP
rs1055419728 1954 dbSNP
rs11340128 1957 dbSNP
rs939550716 1959 dbSNP
rs1166864281 1960 dbSNP
rs1202162185 1962 dbSNP
rs928126242 1963 dbSNP
rs1437510398 1964 dbSNP
rs1329472718 1965 dbSNP
rs1443272113 1966 dbSNP
rs1283942409 1967 dbSNP
rs755196687 1969 dbSNP
rs978260314 1972 dbSNP
rs902615562 1974 dbSNP
rs1334846106 1978 dbSNP
rs1197452766 1979 dbSNP
rs1255670144 1979 dbSNP
rs569046122 1979 dbSNP
rs1182123550 1983 dbSNP
rs1236636851 1990 dbSNP
rs1042363852 1993 dbSNP
rs1183463638 1995 dbSNP
rs915025575 1996 dbSNP
rs550459409 1997 dbSNP
rs989170352 2004 dbSNP
rs964384714 2013 dbSNP
rs1010922369 2014 dbSNP
rs1376159049 2023 dbSNP
rs1278197428 2029 dbSNP
rs1017213846 2030 dbSNP
rs1441897039 2035 dbSNP
rs1410705914 2036 dbSNP
rs1333783203 2039 dbSNP
rs1350793285 2045 dbSNP
rs1303402718 2046 dbSNP
rs1426109168 2050 dbSNP
rs1294359547 2054 dbSNP
rs893690859 2061 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000316292.9 | 3UTR | CAAAAUCUCACUGCAAUCUCCUCCUCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
104 hsa-miR-4776-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT107576 VLDLR very low density lipoprotein receptor 2 2
MIRT183601 SNRPE small nuclear ribonucleoprotein polypeptide E 2 4
MIRT208901 PDCD10 programmed cell death 10 2 2
MIRT441496 IFFO2 intermediate filament family orphan 2 2 2
MIRT441590 PSTK phosphoseryl-tRNA kinase 2 2
MIRT441865 RNASEL ribonuclease L 2 2
MIRT442155 DPY19L1 dpy-19 like C-mannosyltransferase 1 2 2
MIRT442235 DDX19A DEAD-box helicase 19A 2 2
MIRT442519 MOB3B MOB kinase activator 3B 2 2
MIRT443347 STX7 syntaxin 7 2 2
MIRT443598 ZNF91 zinc finger protein 91 2 2
MIRT443725 USP14 ubiquitin specific peptidase 14 2 2
MIRT453650 RAB6C RAB6C, member RAS oncogene family 2 2
MIRT464155 VMP1 vacuole membrane protein 1 2 11
MIRT472507 NACC1 nucleus accumbens associated 1 2 4
MIRT476018 GTF2A1 general transcription factor IIA subunit 1 2 2
MIRT477716 EEF1A1 eukaryotic translation elongation factor 1 alpha 1 2 2
MIRT478545 CTNND1 catenin delta 1 2 2
MIRT481629 ARF1 ADP ribosylation factor 1 2 2
MIRT486451 MDM2 MDM2 proto-oncogene 2 2
MIRT494856 ZNF99 zinc finger protein 99 2 4
MIRT495096 FXR1 FMR1 autosomal homolog 1 2 2
MIRT495766 ZNF546 zinc finger protein 546 2 2
MIRT496650 PITPNM3 PITPNM family member 3 2 2
MIRT496920 CLMN calmin 2 2
MIRT496997 SNAP25 synaptosome associated protein 25 2 2
MIRT497056 C6orf223 chromosome 6 open reading frame 223 2 2
MIRT498391 KIF6 kinesin family member 6 2 2
MIRT499057 CTBP1 C-terminal binding protein 1 2 4
MIRT499093 DENND4C DENN domain containing 4C 2 8
MIRT499860 SVOP SV2 related protein 2 12
MIRT501968 MAPK6 mitogen-activated protein kinase 6 2 2
MIRT504910 CD38 CD38 molecule 2 4
MIRT506781 KLHL15 kelch like family member 15 2 6
MIRT509549 ACTG1 actin gamma 1 2 4
MIRT510814 SBNO1 strawberry notch homolog 1 2 4
MIRT515490 NTRK3 neurotrophic receptor tyrosine kinase 3 2 4
MIRT517752 ZNF366 zinc finger protein 366 2 4
MIRT518553 GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 2 2
MIRT518633 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT518721 ABCG8 ATP binding cassette subfamily G member 8 2 2
MIRT524469 CHRM3 cholinergic receptor muscarinic 3 2 4
MIRT525213 ZNF253 zinc finger protein 253 2 2
MIRT527556 ADCY7 adenylate cyclase 7 2 2
MIRT532691 TCN2 transcobalamin 2 2 4
MIRT533124 YES1 YES proto-oncogene 1, Src family tyrosine kinase 2 2
MIRT534080 SPRY4 sprouty RTK signaling antagonist 4 2 2
MIRT534437 SDR16C5 short chain dehydrogenase/reductase family 16C member 5 2 2
MIRT534997 PRPF40A pre-mRNA processing factor 40 homolog A 2 4
MIRT537160 GGCX gamma-glutamyl carboxylase 2 2
MIRT539359 AFF4 AF4/FMR2 family member 4 2 2
MIRT547019 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT550122 ZNF138 zinc finger protein 138 2 2
MIRT558471 DBN1 drebrin 1 2 2
MIRT563055 ZNF28 zinc finger protein 28 2 2
MIRT563550 SCP2 sterol carrier protein 2 2 2
MIRT566860 LRRC58 leucine rich repeat containing 58 2 2
MIRT567239 HSPA13 heat shock protein family A (Hsp70) member 13 2 2
MIRT572846 BRPF3 bromodomain and PHD finger containing 3 2 2
MIRT573355 PDE3A phosphodiesterase 3A 2 2
MIRT573761 PRKAG1 protein kinase AMP-activated non-catalytic subunit gamma 1 2 2
MIRT574911 Vmp1 vacuole membrane protein 1 2 7
MIRT610172 SEC14L4 SEC14 like lipid binding 4 2 2
MIRT611271 RBMXL1 RNA binding motif protein, X-linked like 1 2 2
MIRT612325 TRPS1 transcriptional repressor GATA binding 1 2 2
MIRT612720 NOL4 nucleolar protein 4 2 2
MIRT613093 ETS1 ETS proto-oncogene 1, transcription factor 2 2
MIRT613759 RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 2 2
MIRT614788 RRAGC Ras related GTP binding C 2 2
MIRT614926 MARCH3 membrane associated ring-CH-type finger 3 2 2
MIRT616777 CD44 CD44 molecule (Indian blood group) 2 2
MIRT616892 DUSP1 dual specificity phosphatase 1 2 2
MIRT618446 SERPINA3 serpin family A member 3 2 2
MIRT619155 PPDPF pancreatic progenitor cell differentiation and proliferation factor 2 2
MIRT619271 CEP57L1 centrosomal protein 57 like 1 2 2
MIRT620899 MUT methylmalonyl-CoA mutase 2 2
MIRT621151 MICALCL MICAL C-terminal like 2 2
MIRT622138 SOX4 SRY-box 4 2 2
MIRT622925 PAK7 p21 (RAC1) activated kinase 5 2 2
MIRT623595 IPO9 importin 9 2 2
MIRT623916 FNBP1L formin binding protein 1 like 2 2
MIRT624072 EBF1 early B-cell factor 1 2 2
MIRT630961 NGDN neuroguidin 2 2
MIRT636738 ADD3 adducin 3 2 2
MIRT639788 MVK mevalonate kinase 2 2
MIRT641106 ZNF274 zinc finger protein 274 2 2
MIRT641573 RFX1 regulatory factor X1 2 2
MIRT643089 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT646457 PRDM10 PR/SET domain 10 2 2
MIRT653068 ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2 2
MIRT657672 GPR26 G protein-coupled receptor 26 2 2
MIRT660287 BICC1 BicC family RNA binding protein 1 2 2
MIRT660354 BAG4 BCL2 associated athanogene 4 2 2
MIRT665823 TIMM8B translocase of inner mitochondrial membrane 8 homolog B 2 2
MIRT678564 ZNF786 zinc finger protein 786 2 2
MIRT691520 ZNF208 zinc finger protein 208 2 2
MIRT695586 TMEM199 transmembrane protein 199 2 2
MIRT698033 TRPM7 transient receptor potential cation channel subfamily M member 7 2 2
MIRT701012 PCGF5 polycomb group ring finger 5 2 2
MIRT701353 NR4A3 nuclear receptor subfamily 4 group A member 3 2 2
MIRT704846 CD55 CD55 molecule (Cromer blood group) 2 2
MIRT707112 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT718656 HNF4A hepatocyte nuclear factor 4 alpha 2 2
MIRT720561 C1RL complement C1r subcomponent like 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4776-3p Paclitaxel 36314 NSC125973 approved resistant High Breast Cancer cell line (Bads-200, Bats-72, BCap37)
hsa-miR-4776-3p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780CIS)
hsa-miR-4776-3p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780CP20)
hsa-miR-4776-3p Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-miR-4776-3p Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-4776-3p Neoadjuvant chemotherapy resistant tissue (breast cancer)

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