pre-miRNA Information
pre-miRNA hsa-mir-4271   
Genomic Coordinates chr3: 49274120 - 49274186
Description Homo sapiens miR-4271 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4271
Sequence 39| GGGGGAAGAAAAGGUGGGG |57
Evidence Experimental
Experiments SOLiD
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30481495 1 COSMIC
COSN31532060 5 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs760829741 1 dbSNP
rs1277951968 2 dbSNP
rs189148716 3 dbSNP
rs757021935 4 dbSNP
rs1285201145 6 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol E2F3   
Synonyms E2F-3
Description E2F transcription factor 3
Transcript NM_001949   
Expression
Putative miRNA Targets on E2F3
3'UTR of E2F3
(miRNA target sites are highlighted)
>E2F3|NM_001949|3'UTR
   1 TTATGCTTCGTGTGAACTCTCCTTAAAAACCGATATTTTTTTATCATGGAACCAGAACATCTGTCATGCAGTGTTGTCCC
  81 TTCCTACCTTCTTCCTCCAAGAGAGTATCATGAAGTAAACTACAAACTTCAGAAGAAAGCTGACATTTTAATGAATTTTT
 161 TAAAAAATTAATAAACAAATTGTCTAAACGCACAGTTGCAGGCTCCCTTGGGAAAGCCCTGCTTTGCTCCAGGCTCCAAG
 241 ATCTCCTGGCTAAGTCAGCAAGTGAGAAAATGTGCAATCAGGTGTCTCTCACCCCGAATTGTCCTTCCTCCTTCCTCCCC
 321 GGATTGGCTTGCTGTGCCTGACGGATGGGCTGTAGAATGGGGTCTGGCCACCTGGCCTGCTGGGAAACAGCAATCTTCCT
 401 TAATAGCATTTCAAGCCGTGCCTTCTCCGCAGAATGCATGTCTTTGAGGTCTGCTAATATGGAATGGAACTGCAGCAAAT
 481 GCAAACTTGAAGTCATGCAAAAGTATGAAATGGATTTCTTCAGCTCTTCTTAGGAATATTTAAATTACTGTCATAATTCA
 561 GTTTAAGCTATGAACTGTGTGTCCCAGTAGGAGGTCAAGAAAACCTCCACAGCCTTCTGGATGAAGAACCTGTTTTCAAA
 641 TATACTTGTTGCAGATACAGAAGACTAGTAGAGTTCTGCCACTCTAAGCTGTTGTGGATTTTCCTGTCTCCATGAACCAC
 721 TCCCATTCCCCCGTCCCCAATGTGTTTGTGAGTTTCCAGTTGATTTGTAGCAAATGCCTACTTAGTTCTTTGTGGATTGT
 801 TCTAGACTTTTAATTTTTTTAGCTGCCATTTAAGCATTCCTGTGGCACCCATCACCATTTCAATTTAATTGTTTACTTTG
 881 AAGCGGTTTTTGCAAATTCATATTACTTAAGCAGAGGGAGAGAACCTCTACTGATCAGAGCATCTAAACCTGTGTGATCT
 961 AAGGTTTATCAGCCTCTGCAAGGAGCTTTGTCCCATCGTGCTTCCATTCCCAGGAGGGGGAGCTTGGAGCGAGTCAGTCC
1041 TGGGGCTTGCTGACATGGGTGGCCCATTGGAAAGGAGAACCAGGTCAGATGATGTAACAGCCCCAAGGAGCAGCAGGCAT
1121 GGGTCCCTCCATCCTTGGGCTTCCCGGGCCCCTGTGACAGGGGAAAGGGCTCTCTTACACCGCACTCAGGGAGACCACTT
1201 CTCAGGATGGGGTCAGATGGAGAGACCTCTAGGGAGAAAGACATCCCCATTGTGTGAGTGGCATTTCCTTAAGCTGGCAG
1281 GAACAGGGAGCAGCCCTGTGTCGGGGGCTGGAATAGTTCTGGCCAGACCCCGTTCCCCTTCCTCTATGAAGGAATAAGTT
1361 GGACCAAGGGAAGTCGGGGACGTAAAAAATGAAGCAAAACAATGCCAGGGTGTCTCCCGCTTTACTCTTCAGGAATGGTG
1441 TCCCAAGTTGGAGGCTTTGTGTCAGCTGCAAATCCTACCAGTTATGTCCAAGAATGGCTTTCCCTCGGGCAGGTGGCAGC
1521 GGCCATCTCCCACTGGGAATATGGCGTAGTATCTCCGGTCCATTCCTTGGATGCTAAGGACTGCGGGAATGAGGGAGTCA
1601 GATAAAGAACAAACCTCGAAACGAACAGTTAAATTGAAATGCTATGTGCCTGACCCAATGGTAGGCACATAGTAGGCACT
1681 CAACTCATATGTTTAATTGAATTGAAAATATCCCTTAGGAAAAAAAAAAAACACACAAAAAACCACAAGAGCCCCAGCCA
1761 GTTTACTCCAGGTAGATTTCCACAATATGCAAAGTGGTGGTGGGGTCAAGACAGATGACACCAGCACTTTAAACTCTTTG
1841 TGTGGGTATGCGTGGGTGTATGTTTGGGAAGAAAAACAAAGGTGCAGACTATCTTCCTTTTTTTCTTCTTCAGCCTCCAT
1921 CCCTGGCCTCCTCCCCTCACACACACTGGACTTGGTACAAAATGTCGGTGTGGTCCTAGATGAAGCATTGGGGTGGGGGA
2001 GGGAGAGGGAGCTTTGTGTTAAGTGCCTACTGGAAATGCACTGTGGGGTTTTTTCCTGTATGGGAAACCATTTATGCCAA
2081 GCTTTTCCCCATTTCCCATATTTATCTCATCTGGTTAGCTGCCTCTGCTTCCAGCTTTGTGTAATTCTCTTTGCCAGCTG
2161 CACAAAGCTGATTTTTTCCAAAGTCTAAAGACTGAGCTCACCTGGCTAGATTGTTGTGTGTTTTGTTGAATTTTTTCATA
2241 ATGTAATGCCGTATTTATTGTTTTTAAAATGAAAGGAATACTAATAAGTCTTAAAAGTTCCTTCATGCATAAGATTTTTT
2321 TCCAGTTACTGGGTTTAACTGGTGTACATTAATTAGATGTCCATACTGTATTTTGTTTGCATTAAGTAATTTTCTTTTTG
2401 ACTTAGTATCCGGCACACAAAGTGGGTTAGTACTACAGTATTTGCGTTACTTTAAGTACTAAGTATGCAGGTTTCCTGGT
2481 ACCATTGAGTTGCTGCTATTAAAGCTCACACACGAAATGGCTAAAAGTTACAAGTGTGCAAATTATGACTGCGTGAGCCT
2561 TAGAAAATAAAATGTATAAAGGGCAACACATGAGCTGTCAAACAGTGTTAGGAGTGTGTTTATATGTACAGAGTTGTGCA
2641 TAGCAATCGTTTTATTTAAGTTGATATGTAGTCTACTCACATTTTCATTATTTAGCAATTTTGTACAAAAATAGCAATTA
2721 ATTTGTAAACACTGCCAGAATACTTTCTAGCTGCTTTGTAATTTTTTAAGAGTGTTATTTTGTTTTTGTTTTTCTGTTCT
2801 TTGTTGTGGCTCTTGTTTTCATTTTTGTTGTACGTGTAGATCTGTAAATAAAATTGCAGTATTTAAAGCTTAAGCTTTCA
2881 GGAAAAAGAAAATAAGAATTCAGTGTGTGCATGACAACTCGTGTGTATGAGAAGGAGGGATATGAAGGAAGATGGCTTGC
2961 AGAGTAAGTCGGGTGGCAATTGTCAGGGTGTGGGAATTTCTTTTCCTACGGGGTACGTGATTTTGTAAAAAGGAAGTATT
3041 TCTCCCAAAATTGGGAGTAGGCAAACTACTAATCAGTTTAGCTTTGTGTTGTATGCTAGTTTAAAAAAGAAAATATGTAA
3121 TATAATGTAAAAAAAAACAAAAAAAAGCTTTTATGATGGATTTTGTAAATAGATTTGTTACAGGGTGACCTGTTCTCTAG
3201 CTGTGATCTTACCACTTCAAATGGGTGTAATTTGAATAAATTTTGTATGGTAAAGGATCAATAAAATGATTTTTTTTAAG
3281 AGTTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ggGGUGGAAAAGAAGGGGg 5'
            |:|||  |||||||:| 
Target 5' tcCTACC--TTCTTCCTCc 3'
82 - 98 145.00 -25.00
2
miRNA  3' ggGGUGGAAAAGAAGGGGg 5'
            || ::||||||||::| 
Target 5' ttCCTTTTTTTCTTCTTCa 3'
1894 - 1912 137.00 -16.90
3
miRNA  3' gggguGGAA--AAGAAGGGGg 5'
               ||||  | |||||:| 
Target 5' attgtCCTTCCTCCTTCCTCc 3'
298 - 318 136.00 -19.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26974419 10 COSMIC
COSN14211145 11 COSMIC
COSN29840172 13 COSMIC
COSN31544974 32 COSMIC
COSN26974417 43 COSMIC
COSN30494068 43 COSMIC
COSN31513244 74 COSMIC
COSN30160857 102 COSMIC
COSN30468939 110 COSMIC
COSN30118943 133 COSMIC
COSN30464428 136 COSMIC
COSN30136784 156 COSMIC
COSN30186334 180 COSMIC
COSN5086288 212 COSMIC
COSN31590396 408 COSMIC
COSN21830139 578 COSMIC
COSN28679858 595 COSMIC
COSN31589538 611 COSMIC
COSN26577245 613 COSMIC
COSN31600769 669 COSMIC
COSN31563724 733 COSMIC
COSN31517906 789 COSMIC
COSN31544721 841 COSMIC
COSN31609187 866 COSMIC
COSN19008156 889 COSMIC
COSN31556649 901 COSMIC
COSN31564499 1006 COSMIC
COSN30545352 1084 COSMIC
COSN17331638 1155 COSMIC
COSN26509206 1170 COSMIC
COSN30165594 1183 COSMIC
COSN31607202 1376 COSMIC
COSN31594832 1383 COSMIC
COSN20628448 1469 COSMIC
COSN8513790 1571 COSMIC
COSN17658989 1618 COSMIC
COSN31482346 1637 COSMIC
COSN31610871 1731 COSMIC
COSN1329678 1732 COSMIC
COSN7866661 2049 COSMIC
COSN31557426 2154 COSMIC
COSN31537787 2413 COSMIC
COSN24301602 2495 COSMIC
COSN31545245 2584 COSMIC
COSN31545067 2596 COSMIC
COSN31482718 2687 COSMIC
COSN31555947 2709 COSMIC
COSN31606713 2767 COSMIC
COSN20091347 2791 COSMIC
COSN30161554 2826 COSMIC
COSN30541308 2835 COSMIC
COSN27681562 2844 COSMIC
COSN27683692 2847 COSMIC
COSN31489201 2902 COSMIC
COSN31590524 3018 COSMIC
COSN30540381 3097 COSMIC
COSN19662907 3128 COSMIC
COSN19660895 3129 COSMIC
COSN31532649 3138 COSMIC
COSN18854244 3139 COSMIC
COSN20102454 3139 COSMIC
COSN31596629 3140 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs773227029 2 dbSNP
rs1226978922 3 dbSNP
rs750584037 3 dbSNP
rs1292211695 6 dbSNP
rs746883408 10 dbSNP
rs771049572 11 dbSNP
rs1256214385 13 dbSNP
rs759177070 22 dbSNP
rs1358425079 25 dbSNP
rs759892274 32 dbSNP
rs199852126 33 dbSNP
rs756538936 33 dbSNP
rs765548421 34 dbSNP
rs1248478834 35 dbSNP
rs780275342 35 dbSNP
rs1425694447 36 dbSNP
rs749610635 36 dbSNP
rs191550792 46 dbSNP
rs763387191 47 dbSNP
rs566721808 56 dbSNP
rs56364223 66 dbSNP
rs1474606537 87 dbSNP
rs1459293870 103 dbSNP
rs1194953661 106 dbSNP
rs1028632619 108 dbSNP
rs954347697 124 dbSNP
rs1008502425 125 dbSNP
rs1030771919 129 dbSNP
rs140174545 144 dbSNP
rs989028146 155 dbSNP
rs1338079085 156 dbSNP
rs1391813139 156 dbSNP
rs1400453674 162 dbSNP
rs558655818 162 dbSNP
rs576846225 168 dbSNP
rs4134983 169 dbSNP
rs1459480645 173 dbSNP
rs980321710 181 dbSNP
rs1342482054 190 dbSNP
rs927517720 191 dbSNP
rs182906095 199 dbSNP
rs1194831612 200 dbSNP
rs1057441109 218 dbSNP
rs1265850508 226 dbSNP
rs1193462636 227 dbSNP
rs1489147722 228 dbSNP
rs535500716 230 dbSNP
rs1278160464 232 dbSNP
rs1315681105 234 dbSNP
rs1259652389 262 dbSNP
rs1218988965 274 dbSNP
rs1299049691 277 dbSNP
rs1388466593 296 dbSNP
rs1368321469 297 dbSNP
rs907989682 300 dbSNP
rs186978420 305 dbSNP
rs1402704619 313 dbSNP
rs1247514416 321 dbSNP
rs764084652 322 dbSNP
rs1376307995 323 dbSNP
rs1265655729 328 dbSNP
rs1037546149 330 dbSNP
rs1407980908 333 dbSNP
rs1177451012 335 dbSNP
rs751571493 343 dbSNP
rs1207714000 344 dbSNP
rs1240281392 355 dbSNP
rs1198918356 362 dbSNP
rs1460664961 363 dbSNP
rs866450335 371 dbSNP
rs1235235080 372 dbSNP
rs1488349402 375 dbSNP
rs1306265780 377 dbSNP
rs931911800 383 dbSNP
rs1379254365 394 dbSNP
rs1192829379 418 dbSNP
rs1452208862 419 dbSNP
rs542072016 429 dbSNP
rs556692128 430 dbSNP
rs1363702909 433 dbSNP
rs1008556509 435 dbSNP
rs1437234877 437 dbSNP
rs1165138575 438 dbSNP
rs1367694820 440 dbSNP
rs1178800016 450 dbSNP
rs1457553600 471 dbSNP
rs1253722144 478 dbSNP
rs1201942675 480 dbSNP
rs1483479741 507 dbSNP
rs1285176028 511 dbSNP
rs1161942289 518 dbSNP
rs1031076652 527 dbSNP
rs1310087576 527 dbSNP
rs1245425272 537 dbSNP
rs892222800 545 dbSNP
rs1011031840 551 dbSNP
rs1396941441 553 dbSNP
rs1021808219 573 dbSNP
rs572345281 578 dbSNP
rs575132721 580 dbSNP
rs1362510127 612 dbSNP
rs968904066 622 dbSNP
rs1361818252 623 dbSNP
rs191402559 658 dbSNP
rs1034640365 659 dbSNP
rs960273097 659 dbSNP
rs1189231870 660 dbSNP
rs1398307271 663 dbSNP
rs1313807614 664 dbSNP
rs992853187 695 dbSNP
rs1321518328 702 dbSNP
rs1489229895 705 dbSNP
rs1242111130 707 dbSNP
rs1209297186 710 dbSNP
rs564632005 714 dbSNP
rs531681460 729 dbSNP
rs4134984 733 dbSNP
rs183649544 734 dbSNP
rs940806296 741 dbSNP
rs1326156281 749 dbSNP
rs973866112 761 dbSNP
rs920665413 768 dbSNP
rs1283271969 779 dbSNP
rs1341665767 781 dbSNP
rs931838156 783 dbSNP
rs1182402963 788 dbSNP
rs1387977949 800 dbSNP
rs755216364 806 dbSNP
rs1050214261 807 dbSNP
rs1421882036 811 dbSNP
rs530017043 814 dbSNP
rs890405747 815 dbSNP
rs1181951216 821 dbSNP
rs1478710445 827 dbSNP
rs1263773334 842 dbSNP
rs1382456077 843 dbSNP
rs779212686 847 dbSNP
rs1449884422 852 dbSNP
rs944586815 854 dbSNP
rs1158051118 855 dbSNP
rs1052108463 862 dbSNP
rs1256463627 867 dbSNP
rs1220825052 871 dbSNP
rs1319075215 872 dbSNP
rs1343521164 884 dbSNP
rs892101153 885 dbSNP
rs1328783548 886 dbSNP
rs1010559047 888 dbSNP
rs1386909119 889 dbSNP
rs1303962662 900 dbSNP
rs187910150 916 dbSNP
rs1466952640 924 dbSNP
rs904941451 927 dbSNP
rs772446034 932 dbSNP
rs1377100316 937 dbSNP
rs1477002823 938 dbSNP
rs1379366036 939 dbSNP
rs1432552405 949 dbSNP
rs1457408232 951 dbSNP
rs566758940 952 dbSNP
rs527511531 953 dbSNP
rs1236541634 960 dbSNP
rs1200782597 975 dbSNP
rs1458450844 979 dbSNP
rs1278368089 981 dbSNP
rs552061012 991 dbSNP
rs960283091 993 dbSNP
rs1276015538 995 dbSNP
rs1234346784 998 dbSNP
rs993466309 1012 dbSNP
rs570543556 1017 dbSNP
rs537505973 1018 dbSNP
rs556130215 1019 dbSNP
rs1313475713 1031 dbSNP
rs751465698 1031 dbSNP
rs920716222 1032 dbSNP
rs1255395568 1040 dbSNP
rs1482143400 1041 dbSNP
rs1200372828 1046 dbSNP
rs932057664 1052 dbSNP
rs1180672049 1082 dbSNP
rs1440547453 1083 dbSNP
rs985934420 1085 dbSNP
rs911686262 1086 dbSNP
rs944658216 1092 dbSNP
rs369329259 1095 dbSNP
rs1279908486 1099 dbSNP
rs1216546175 1101 dbSNP
rs1052811138 1104 dbSNP
rs1440488289 1109 dbSNP
rs913802483 1111 dbSNP
rs1178280847 1118 dbSNP
rs1373589073 1120 dbSNP
rs1283285062 1121 dbSNP
rs567765034 1123 dbSNP
rs756498022 1130 dbSNP
rs1435019480 1136 dbSNP
rs1177395534 1141 dbSNP
rs1359163989 1146 dbSNP
rs193045881 1147 dbSNP
rs1043404996 1159 dbSNP
rs1413311104 1173 dbSNP
rs1180371486 1177 dbSNP
rs904953086 1181 dbSNP
rs1238421975 1182 dbSNP
rs1401512908 1183 dbSNP
rs1309440995 1184 dbSNP
rs1001916911 1187 dbSNP
rs1288854286 1196 dbSNP
rs1487589202 1196 dbSNP
rs1218136837 1207 dbSNP
rs554075842 1213 dbSNP
rs778227610 1223 dbSNP
rs1055993959 1230 dbSNP
rs1358122792 1235 dbSNP
rs572380681 1236 dbSNP
rs185351691 1245 dbSNP
rs1338311913 1246 dbSNP
rs1300010152 1249 dbSNP
rs4134985 1250 dbSNP
rs1220404508 1251 dbSNP
rs1015613846 1252 dbSNP
rs1349396787 1264 dbSNP
rs1162870634 1273 dbSNP
rs962314975 1278 dbSNP
rs576489430 1294 dbSNP
rs995278674 1304 dbSNP
rs1027577764 1316 dbSNP
rs1477073922 1319 dbSNP
rs543504487 1326 dbSNP
rs986153645 1332 dbSNP
rs562156542 1333 dbSNP
rs966296438 1343 dbSNP
rs987990972 1345 dbSNP
rs913841617 1347 dbSNP
rs189929537 1348 dbSNP
rs946621123 1352 dbSNP
rs1215098685 1359 dbSNP
rs1424752313 1368 dbSNP
rs1291849699 1375 dbSNP
rs1043416905 1376 dbSNP
rs1395466372 1376 dbSNP
rs926256158 1377 dbSNP
rs541416153 1382 dbSNP
rs770466832 1383 dbSNP
rs896217449 1384 dbSNP
rs560471133 1390 dbSNP
rs1014874352 1403 dbSNP
rs375068453 1415 dbSNP
rs1292375880 1419 dbSNP
rs1343118882 1420 dbSNP
rs1036521515 1421 dbSNP
rs1220345109 1425 dbSNP
rs1469453296 1437 dbSNP
rs776063248 1439 dbSNP
rs1278810085 1443 dbSNP
rs1317048414 1446 dbSNP
rs898078015 1449 dbSNP
rs995010112 1454 dbSNP
rs1027628681 1467 dbSNP
rs1205037282 1477 dbSNP
rs527559660 1485 dbSNP
rs181590088 1486 dbSNP
rs541918297 1491 dbSNP
rs1007498226 1507 dbSNP
rs1371855181 1508 dbSNP
rs1308735727 1511 dbSNP
rs1019488005 1512 dbSNP
rs1222618776 1519 dbSNP
rs966147066 1522 dbSNP
rs1299088246 1540 dbSNP
rs1465898939 1543 dbSNP
rs988388470 1546 dbSNP
rs139667103 1547 dbSNP
rs572737857 1557 dbSNP
rs979316507 1561 dbSNP
rs1196446285 1575 dbSNP
rs1264608978 1585 dbSNP
rs1437426179 1586 dbSNP
rs531531614 1600 dbSNP
rs1482827538 1604 dbSNP
rs775238500 1610 dbSNP
rs937682403 1616 dbSNP
rs1166444920 1618 dbSNP
rs1416425215 1619 dbSNP
rs991819432 1623 dbSNP
rs1405538377 1625 dbSNP
rs917690216 1634 dbSNP
rs1308029366 1638 dbSNP
rs939750999 1647 dbSNP
rs1377467296 1650 dbSNP
rs1305052684 1655 dbSNP
rs1435890824 1659 dbSNP
rs762788898 1661 dbSNP
rs1363129445 1673 dbSNP
rs1360517801 1681 dbSNP
rs1036940521 1683 dbSNP
rs1417371860 1687 dbSNP
rs1298717807 1688 dbSNP
rs897970445 1691 dbSNP
rs1182116676 1718 dbSNP
rs1422977572 1718 dbSNP
rs1029182658 1720 dbSNP
rs1332684130 1720 dbSNP
rs747112786 1720 dbSNP
rs930909223 1721 dbSNP
rs1049328510 1731 dbSNP
rs1491049039 1731 dbSNP
rs549503893 1731 dbSNP
rs879099108 1732 dbSNP
rs1428568660 1733 dbSNP
rs567797275 1737 dbSNP
rs1007550693 1743 dbSNP
rs4134986 1747 dbSNP
rs35111005 1749 dbSNP
rs1229075892 1750 dbSNP
rs1291382891 1754 dbSNP
rs1357359491 1760 dbSNP
rs553321334 1761 dbSNP
rs1158727573 1767 dbSNP
rs1457098771 1771 dbSNP
rs749381101 1773 dbSNP
rs901928066 1775 dbSNP
rs1166799333 1781 dbSNP
rs1009633207 1794 dbSNP
rs1262340503 1801 dbSNP
rs1446873786 1804 dbSNP
rs561508460 1807 dbSNP
rs1380320312 1824 dbSNP
rs1262528312 1835 dbSNP
rs1209389746 1836 dbSNP
rs1487618133 1837 dbSNP
rs1191695573 1839 dbSNP
rs183947206 1840 dbSNP
rs1317720689 1842 dbSNP
rs1473354683 1847 dbSNP
rs1221016335 1853 dbSNP
rs1180901907 1857 dbSNP
rs1327608870 1862 dbSNP
rs188385499 1864 dbSNP
rs1420982223 1866 dbSNP
rs1388096574 1874 dbSNP
rs1327539551 1883 dbSNP
rs1461728886 1886 dbSNP
rs1158661339 1893 dbSNP
rs1422676871 1895 dbSNP
rs1168371923 1898 dbSNP
rs562213888 1898 dbSNP
rs979243026 1903 dbSNP
rs1398837051 1906 dbSNP
rs1336133372 1909 dbSNP
rs1359500309 1911 dbSNP
rs1447085269 1912 dbSNP
rs4134987 1913 dbSNP
rs1380778644 1914 dbSNP
rs1033634104 1915 dbSNP
rs529375562 1916 dbSNP
rs991829293 1918 dbSNP
rs779170092 1920 dbSNP
rs558333687 1922 dbSNP
rs939784174 1923 dbSNP
rs576605115 1927 dbSNP
rs1340650468 1930 dbSNP
rs1274817472 1931 dbSNP
rs972480976 1934 dbSNP
rs761912445 1938 dbSNP
rs543981914 1942 dbSNP
rs1441189446 1944 dbSNP
rs1399184724 1948 dbSNP
rs1329032381 1950 dbSNP
rs1049213285 1964 dbSNP
rs1397080640 1966 dbSNP
rs180850030 1967 dbSNP
rs1241697877 1968 dbSNP
rs1441105085 1969 dbSNP
rs1194429416 1970 dbSNP
rs1439313977 1978 dbSNP
rs1178899097 1988 dbSNP
rs1236639950 1989 dbSNP
rs1184388916 1992 dbSNP
rs1438788251 1993 dbSNP
rs1278478926 2002 dbSNP
rs866694422 2005 dbSNP
rs1379117565 2010 dbSNP
rs1199260266 2013 dbSNP
rs574154470 2017 dbSNP
rs943585144 2020 dbSNP
rs1234462794 2038 dbSNP
rs1174230003 2040 dbSNP
rs1402903110 2049 dbSNP
rs1444053249 2050 dbSNP
rs1336148881 2056 dbSNP
rs1333363100 2061 dbSNP
rs1413839770 2075 dbSNP
rs1040798307 2085 dbSNP
rs1377272014 2087 dbSNP
rs1174324968 2090 dbSNP
rs1209043919 2091 dbSNP
rs748476997 2092 dbSNP
rs1449229610 2098 dbSNP
rs1009971341 2099 dbSNP
rs1277008364 2112 dbSNP
rs1021063402 2115 dbSNP
rs1486935550 2119 dbSNP
rs903934000 2121 dbSNP
rs541452906 2141 dbSNP
rs1332348687 2142 dbSNP
rs1335226057 2158 dbSNP
rs1281636248 2161 dbSNP
rs1225125163 2162 dbSNP
rs1351041314 2172 dbSNP
rs766472230 2187 dbSNP
rs753805799 2188 dbSNP
rs1237049628 2200 dbSNP
rs544644267 2206 dbSNP
rs1357264436 2209 dbSNP
rs184958522 2217 dbSNP
rs1399428903 2221 dbSNP
rs1343523622 2223 dbSNP
rs755092438 2226 dbSNP
rs190937838 2241 dbSNP
rs1413423177 2243 dbSNP
rs1161807104 2244 dbSNP
rs959276506 2247 dbSNP
rs545827310 2249 dbSNP
rs1419156114 2251 dbSNP
rs562787983 2252 dbSNP
rs1487640975 2255 dbSNP
rs750466715 2261 dbSNP
rs1223463477 2270 dbSNP
rs992064833 2277 dbSNP
rs1459400409 2279 dbSNP
rs1198856513 2282 dbSNP
rs35225726 2293 dbSNP
rs1231183578 2295 dbSNP
rs1249449188 2299 dbSNP
rs1343922119 2310 dbSNP
rs1217942904 2312 dbSNP
rs765326057 2325 dbSNP
rs748284638 2329 dbSNP
rs1042317 2335 dbSNP
rs1377716321 2337 dbSNP
rs57922460 2340 dbSNP
rs1431641758 2342 dbSNP
rs149773947 2345 dbSNP
rs549540677 2346 dbSNP
rs1174230718 2348 dbSNP
rs1170502457 2353 dbSNP
rs1425470177 2354 dbSNP
rs1422342792 2355 dbSNP
rs1465992329 2359 dbSNP
rs1245719347 2371 dbSNP
rs1475478697 2371 dbSNP
rs1211456172 2376 dbSNP
rs1469596002 2382 dbSNP
rs1273578188 2383 dbSNP
rs1171636578 2391 dbSNP
rs972790773 2403 dbSNP
rs919711701 2405 dbSNP
rs1305674676 2409 dbSNP
rs952430738 2411 dbSNP
rs1215193021 2412 dbSNP
rs561465783 2413 dbSNP
rs560743891 2415 dbSNP
rs1331784028 2419 dbSNP
rs1249050056 2430 dbSNP
rs747485409 2432 dbSNP
rs182027017 2446 dbSNP
rs1040659012 2447 dbSNP
rs766807450 2447 dbSNP
rs1320429135 2466 dbSNP
rs1356756329 2468 dbSNP
rs1171760556 2480 dbSNP
rs1409984742 2486 dbSNP
rs527963114 2490 dbSNP
rs1366400266 2491 dbSNP
rs187074627 2510 dbSNP
rs945438696 2512 dbSNP
rs1042771056 2514 dbSNP
rs1253295435 2515 dbSNP
rs1177745851 2521 dbSNP
rs1211292420 2523 dbSNP
rs1252946629 2529 dbSNP
rs1205146804 2531 dbSNP
rs903943809 2532 dbSNP
rs1278275533 2535 dbSNP
rs1267394354 2537 dbSNP
rs1308853884 2539 dbSNP
rs1000911597 2540 dbSNP
rs771357661 2541 dbSNP
rs112065694 2545 dbSNP
rs77872144 2546 dbSNP
rs747501848 2550 dbSNP
rs145742366 2553 dbSNP
rs894951039 2554 dbSNP
rs1478024248 2557 dbSNP
rs4134988 2575 dbSNP
rs1436090836 2581 dbSNP
rs1395273626 2583 dbSNP
rs745847670 2596 dbSNP
rs1417019806 2599 dbSNP
rs549615225 2599 dbSNP
rs757646504 2602 dbSNP
rs1485295516 2617 dbSNP
rs1165260521 2618 dbSNP
rs1366249095 2624 dbSNP
rs1255377648 2626 dbSNP
rs1213071336 2629 dbSNP
rs1348726818 2641 dbSNP
rs570309015 2647 dbSNP
rs60408508 2649 dbSNP
rs1026570396 2650 dbSNP
rs952483683 2650 dbSNP
rs1354082050 2660 dbSNP
rs985149294 2669 dbSNP
rs555963268 2674 dbSNP
rs1416042926 2680 dbSNP
rs1375531066 2681 dbSNP
rs745328770 2696 dbSNP
rs1287856063 2707 dbSNP
rs910959307 2712 dbSNP
rs1295247690 2715 dbSNP
rs1365239427 2725 dbSNP
rs1159531794 2731 dbSNP
rs769370298 2741 dbSNP
rs976656703 2744 dbSNP
rs1190008507 2758 dbSNP
rs1246499772 2759 dbSNP
rs79842081 2761 dbSNP
rs75902881 2763 dbSNP
rs1265715561 2770 dbSNP
rs191574805 2772 dbSNP
rs769686639 2776 dbSNP
rs577740898 2777 dbSNP
rs1358092926 2794 dbSNP
rs535204793 2797 dbSNP
rs4134989 2801 dbSNP
rs553431353 2804 dbSNP
rs1185891031 2810 dbSNP
rs1259361863 2813 dbSNP
rs1340514761 2818 dbSNP
rs577991553 2828 dbSNP
rs1294214516 2829 dbSNP
rs1380073549 2830 dbSNP
rs1386640066 2831 dbSNP
rs144083937 2834 dbSNP
rs571021462 2835 dbSNP
rs568802323 2837 dbSNP
rs1055243409 2841 dbSNP
rs1386168728 2844 dbSNP
rs1444238928 2845 dbSNP
rs1166914406 2850 dbSNP
rs1161683420 2856 dbSNP
rs1362558970 2857 dbSNP
rs1454728721 2859 dbSNP
rs1288842555 2863 dbSNP
rs1383236991 2865 dbSNP
rs895214264 2869 dbSNP
rs1013459338 2881 dbSNP
rs1312982890 2885 dbSNP
rs1046622156 2895 dbSNP
rs1381503140 2896 dbSNP
rs1243337204 2901 dbSNP
rs1467370342 2905 dbSNP
rs897073518 2911 dbSNP
rs1214774522 2918 dbSNP
rs1339281481 2921 dbSNP
rs528804010 2922 dbSNP
rs1353846203 2935 dbSNP
rs547168892 2946 dbSNP
rs564249216 2949 dbSNP
rs1026621298 2956 dbSNP
rs952412411 2958 dbSNP
rs768568055 2971 dbSNP
rs1484108931 2972 dbSNP
rs1018020311 2977 dbSNP
rs1395632397 2980 dbSNP
rs1166105853 2994 dbSNP
rs1463535030 2996 dbSNP
rs1200748955 3005 dbSNP
rs1242311217 3010 dbSNP
rs568666935 3011 dbSNP
rs965495428 3017 dbSNP
rs1182015287 3018 dbSNP
rs1437647870 3037 dbSNP
rs976283014 3084 dbSNP
rs576255311 3087 dbSNP
rs1159007131 3094 dbSNP
rs967002994 3098 dbSNP
rs978308592 3111 dbSNP
rs748907544 3117 dbSNP
rs543226128 3124 dbSNP
rs146499346 3126 dbSNP
rs1436868358 3128 dbSNP
rs1468036350 3128 dbSNP
rs754411000 3129 dbSNP
rs879698734 3129 dbSNP
rs925512077 3129 dbSNP
rs1438924089 3130 dbSNP
rs1405839305 3135 dbSNP
rs936678365 3135 dbSNP
rs1449973292 3136 dbSNP
rs878972635 3137 dbSNP
rs201254207 3138 dbSNP
rs990816209 3138 dbSNP
rs199794702 3139 dbSNP
rs79489313 3139 dbSNP
rs949460078 3139 dbSNP
rs1046249257 3147 dbSNP
rs1222773387 3149 dbSNP
rs1438875709 3154 dbSNP
rs896952937 3156 dbSNP
rs1313822142 3157 dbSNP
rs1233902686 3160 dbSNP
rs929814698 3179 dbSNP
rs1484415775 3182 dbSNP
rs767293643 3183 dbSNP
rs1281944383 3184 dbSNP
rs1262230601 3193 dbSNP
rs781575132 3211 dbSNP
rs1240983650 3221 dbSNP
rs1351001414 3233 dbSNP
rs1201989040 3246 dbSNP
rs1377369808 3250 dbSNP
rs1048324571 3258 dbSNP
rs888363260 3266 dbSNP
rs1006547470 3270 dbSNP
rs1160623821 3270 dbSNP
rs1470734067 3278 dbSNP
rs1417710244 3280 dbSNP
rs773235226 3281 dbSNP
rs1017859586 3282 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 1871.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gggguggaaaAGAAGGGGg 5'
                    |:|||||| 
Target 5' ---------cUUUUCCCCa 3'
1 - 10
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gggguggaaaAGAAGGGGg 5'
                    |:|||||| 
Target 5' ----ccaagcUUUUCCCCa 3'
1 - 15
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177609. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_2_11 PAR-CLIP data was present in ERX177628. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_4_6 PAR-CLIP data was present in ERX177599. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_1 PAR-CLIP data was present in ERX177603. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_5 PAR-CLIP data was present in ERX177604. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_2_6 PAR-CLIP data was present in ERX177605. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_2_7 PAR-CLIP data was present in ERX177606. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_2_8 PAR-CLIP data was present in ERX177615. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_3_5 PAR-CLIP data was present in ERX177616. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_3_6 PAR-CLIP data was present in ERX177617. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_3_7 PAR-CLIP data was present in ERX177621. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_3_11 PAR-CLIP data was present in ERX177627. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_4_5 PAR-CLIP data was present in ERX177629. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_4_7 PAR-CLIP data was present in ERX177630. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_4_8 PAR-CLIP data was present in ERX177633. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_4_11 PAR-CLIP data was present in ERX177618. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_3_8 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
Experimental Support 4 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions Prostate Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRX1760638. RNA binding protein: AGO2. Condition:AGO-CLIP-PC3-miR148 ...

- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.).

Article - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al.
- Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
CLIP-seq Support 1 for dataset GSM4903825
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID14_NS
Location of target site NM_001949 | 3UTR | CAUUUCCCAUAUUUAUCUCAUCUGGUUAGCUGCCUCUGCUUCCAGCUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_001949 | 3UTR | CCUGUAUGGGAAACCAUUUAUGCCAAGCUUUUCCCCAUUUCCCAUAUUUAUCUCAUCUGGUUAGCUGCCUCUGCUUCCAGCUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_001949 | 3UTR | UCCCCAUUUCCCAUAUUUAUCUCAUCUGGUUAGCUGCCUCUGCUUCCAGCUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_001949 | 3UTR | UGUAUGGGAAACCAUUUAUGCCAAGCUUUUCCCCAUUUCCCAUAUUUAUCUCAUCUGGUUAGCUGCCUCUGCUUCCAGCUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000346618.3 | 3UTR | CUUUUCCCCAUUUCCCAUAUUUAUCUCAUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000346618.3 | 3UTR | CCAAGCUUUUCCCCAUUUCCCAUAUUUAUCUCAUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
181 hsa-miR-4271 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066209 MARCH9 membrane associated ring-CH-type finger 9 2 2
MIRT079367 CCDC137 coiled-coil domain containing 137 2 2
MIRT081183 MIDN midnolin 2 4
MIRT083278 ZCCHC3 zinc finger CCHC-type containing 3 2 6
MIRT086207 HOXD13 homeobox D13 2 2
MIRT133713 SKI SKI proto-oncogene 2 4
MIRT150653 SLC27A1 solute carrier family 27 member 1 2 2
MIRT159166 NRBP1 nuclear receptor binding protein 1 2 2
MIRT160059 TET3 tet methylcytosine dioxygenase 3 2 4
MIRT180856 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 2
MIRT181931 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT190628 BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough 2 2
MIRT190654 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT196107 MPRIP myosin phosphatase Rho interacting protein 2 2
MIRT263248 SGPL1 sphingosine-1-phosphate lyase 1 2 2
MIRT321168 EIF4H eukaryotic translation initiation factor 4H 2 2
MIRT338624 SHMT2 serine hydroxymethyltransferase 2 2 2
MIRT366301 GDI1 GDP dissociation inhibitor 1 2 4
MIRT375172 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 2
MIRT441488 NCEH1 neutral cholesterol ester hydrolase 1 2 2
MIRT442333 WNT9B Wnt family member 9B 2 2
MIRT443889 CNKSR3 CNKSR family member 3 2 2
MIRT445880 WBP1L WW domain binding protein 1 like 2 2
MIRT449312 MRO maestro 2 2
MIRT449844 BCL2L13 BCL2 like 13 2 2
MIRT450304 DRAXIN dorsal inhibitory axon guidance protein 2 2
MIRT450515 EMX1 empty spiracles homeobox 1 2 2
MIRT451243 ZNF444 zinc finger protein 444 2 2
MIRT451713 OLR1 oxidized low density lipoprotein receptor 1 2 2
MIRT451792 TLR5 toll like receptor 5 2 2
MIRT451823 ALDH3B1 aldehyde dehydrogenase 3 family member B1 2 2
MIRT451906 ILK integrin linked kinase 2 2
MIRT452181 KIAA1456 KIAA1456 2 4
MIRT452242 TRAM1 translocation associated membrane protein 1 2 2
MIRT452544 ZNF467 zinc finger protein 467 2 2
MIRT452605 REPIN1 replication initiator 1 2 2
MIRT454505 ZFYVE27 zinc finger FYVE-type containing 27 2 2
MIRT454657 FBXL18 F-box and leucine rich repeat protein 18 2 2
MIRT455354 KDM5C lysine demethylase 5C 2 2
MIRT455452 EPB41L4B erythrocyte membrane protein band 4.1 like 4B 2 2
MIRT455587 TAF12 TATA-box binding protein associated factor 12 2 2
MIRT456501 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 2 2
MIRT456815 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT457425 NOL10 nucleolar protein 10 2 2
MIRT457468 SLC35F6 solute carrier family 35 member F6 2 2
MIRT457660 SERINC1 serine incorporator 1 2 2
MIRT458231 NXPH3 neurexophilin 3 2 2
MIRT458374 ITM2C integral membrane protein 2C 2 2
MIRT458667 GPR35 G protein-coupled receptor 35 2 2
MIRT459665 VPS37C VPS37C, ESCRT-I subunit 2 2
MIRT459825 TPP1 tripeptidyl peptidase 1 2 2
MIRT460564 FEM1A fem-1 homolog A 2 2
MIRT460725 ASXL3 additional sex combs like 3, transcriptional regulator 2 2
MIRT461121 RAB36 RAB36, member RAS oncogene family 2 2
MIRT461529 C14orf1 ergosterol biosynthesis 28 homolog 2 2
MIRT461750 DDX11 DEAD/H-box helicase 11 2 2
MIRT462570 STS steroid sulfatase 2 2
MIRT462798 NTN1 netrin 1 2 2
MIRT463030 ZNF689 zinc finger protein 689 2 2
MIRT463991 WDTC1 WD and tetratricopeptide repeats 1 2 2
MIRT464684 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT465439 TP53 tumor protein p53 2 2
MIRT465512 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT465649 TNPO2 transportin 2 2 10
MIRT465947 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT466028 TMEM189 transmembrane protein 189 2 2
MIRT468076 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 6
MIRT468131 SH3PXD2A SH3 and PX domains 2A 2 2
MIRT468498 SESN2 sestrin 2 2 2
MIRT468879 RREB1 ras responsive element binding protein 1 2 2
MIRT469318 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT469558 RARA retinoic acid receptor alpha 2 2
MIRT469793 RAB15 RAB15, member RAS oncogene family 2 2
MIRT469896 PTRF caveolae associated protein 1 2 2
MIRT470235 PRRC2A proline rich coiled-coil 2A 2 2
MIRT470808 PLXND1 plexin D1 2 2
MIRT471597 PAQR5 progestin and adipoQ receptor family member 5 2 10
MIRT471710 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT471752 OGT O-linked N-acetylglucosamine (GlcNAc) transferase 2 2
MIRT472978 MRRF mitochondrial ribosome recycling factor 2 2
MIRT473538 MAX MYC associated factor X 2 2
MIRT473581 MAT2A methionine adenosyltransferase 2A 2 2
MIRT473970 LRRC58 leucine rich repeat containing 58 2 2
MIRT474223 LCOR ligand dependent nuclear receptor corepressor 2 4
MIRT474553 KLHDC3 kelch domain containing 3 2 2
MIRT474777 KIAA0895L KIAA0895 like 2 2
MIRT476042 GRSF1 G-rich RNA sequence binding factor 1 2 2
MIRT476438 GBA2 glucosylceramidase beta 2 2 2
MIRT477773 E2F3 E2F transcription factor 3 2 4
MIRT477946 DPM2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory 2 2
MIRT478782 CRTC2 CREB regulated transcription coactivator 2 2 2
MIRT479320 VPS72 vacuolar protein sorting 72 homolog 2 2
MIRT480405 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT480593 BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 2 2
MIRT480963 BBC3 BCL2 binding component 3 2 2
MIRT481127 AZIN1 antizyme inhibitor 1 2 4
MIRT481444 ARRB2 arrestin beta 2 2 2
MIRT481687 AR androgen receptor 2 2
MIRT481730 APH1A aph-1 homolog A, gamma-secretase subunit 2 2
MIRT482386 AEN apoptosis enhancing nuclease 2 2
MIRT482564 ABHD2 abhydrolase domain containing 2 2 2
MIRT482605 ABHD14B abhydrolase domain containing 14B 2 2
MIRT483256 CITED4 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 2 4
MIRT483531 TAGLN2 transgelin 2 2 2
MIRT483840 UNC5B unc-5 netrin receptor B 2 4
MIRT483935 LENG8 leukocyte receptor cluster member 8 2 4
MIRT484414 SNX19 sorting nexin 19 2 2
MIRT484487 SLC9A1 solute carrier family 9 member A1 2 2
MIRT484609 SIX3 SIX homeobox 3 2 6
MIRT484703 RNF11 ring finger protein 11 2 2
MIRT485244 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT485607 FOSL1 FOS like 1, AP-1 transcription factor subunit 2 4
MIRT485965 RTBDN retbindin 2 2
MIRT487308 GLTSCR1 BRD4 interacting chromatin remodeling complex associated protein 2 2
MIRT487329 SREBF1 sterol regulatory element binding transcription factor 1 2 4
MIRT487410 CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 2 2
MIRT487607 C20orf96 chromosome 20 open reading frame 96 2 2
MIRT487689 CDK14 cyclin dependent kinase 14 2 2
MIRT487787 GPR20 G protein-coupled receptor 20 2 4
MIRT488026 ADO 2-aminoethanethiol dioxygenase 2 2
MIRT488476 B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 2 2
MIRT488761 FXYD1 FXYD domain containing ion transport regulator 1 2 2
MIRT489161 MRPL12 mitochondrial ribosomal protein L12 2 4
MIRT489529 MRE11A MRE11 homolog, double strand break repair nuclease 2 8
MIRT489774 GRINA glutamate ionotropic receptor NMDA type subunit associated protein 1 2 2
MIRT489878 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT490094 FN3K fructosamine 3 kinase 2 2
MIRT490202 PKNOX2 PBX/knotted 1 homeobox 2 2 2
MIRT490283 ISL2 ISL LIM homeobox 2 2 2
MIRT490377 LHFPL3 LHFPL tetraspan subfamily member 3 2 2
MIRT491035 ALPK3 alpha kinase 3 2 2
MIRT491186 JUND JunD proto-oncogene, AP-1 transcription factor subunit 2 4
MIRT491766 ZNF385A zinc finger protein 385A 2 2
MIRT491888 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon 2 2
MIRT491981 UNK unkempt family zinc finger 2 2
MIRT492400 SDK1 sidekick cell adhesion molecule 1 2 2
MIRT493647 HDLBP high density lipoprotein binding protein 2 2
MIRT494010 DUSP9 dual specificity phosphatase 9 2 2
MIRT494167 CNOT6L CCR4-NOT transcription complex subunit 6 like 2 2
MIRT495712 PADI1 peptidyl arginine deiminase 1 2 2
MIRT496873 AHCYL2 adenosylhomocysteinase like 2 2 2
MIRT499175 RBPJL recombination signal binding protein for immunoglobulin kappa J region like 2 2
MIRT501652 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT506645 MAPK1 mitogen-activated protein kinase 1 2 4
MIRT510590 TUBB2A tubulin beta 2A class IIa 2 6
MIRT511907 FKBP1A FK506 binding protein 1A 2 2
MIRT513063 ANKRD45 ankyrin repeat domain 45 2 2
MIRT513104 DYNAP dynactin associated protein 2 2
MIRT521804 POM121C POM121 transmembrane nucleoporin C 2 2
MIRT523520 GLUL glutamate-ammonia ligase 2 2
MIRT525085 FRK fyn related Src family tyrosine kinase 2 2
MIRT530930 SCIN scinderin 2 2
MIRT533501 TRIM71 tripartite motif containing 71 2 2
MIRT538560 CECR2 CECR2, histone acetyl-lysine reader 2 2
MIRT544556 CSNK2A1 casein kinase 2 alpha 1 2 2
MIRT555912 ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 2 2
MIRT560405 TMEM69 transmembrane protein 69 2 2
MIRT560664 RTN3 reticulon 3 2 2
MIRT564061 CDT1 chromatin licensing and DNA replication factor 1 2 2
MIRT565504 SP1 Sp1 transcription factor 2 2
MIRT570014 COL1A2 collagen type I alpha 2 chain 2 2
MIRT572321 HSPB6 heat shock protein family B (small) member 6 2 2
MIRT573229 TRIM21 tripartite motif containing 21 2 2
MIRT573487 IQSEC3 IQ motif and Sec7 domain 3 2 2
MIRT574137 MARVELD1 MARVEL domain containing 1 2 2
MIRT574323 ZNF703 zinc finger protein 703 2 2
MIRT620939 OSMR oncostatin M receptor 2 2
MIRT650080 MTL5 testis expressed metallothionein like protein 2 2
MIRT684553 ZNF708 zinc finger protein 708 2 2
MIRT685841 ANGEL1 angel homolog 1 2 2
MIRT688551 DCAF16 DDB1 and CUL4 associated factor 16 2 2
MIRT701985 MIER3 MIER family member 3 2 2
MIRT703899 EPT1 selenoprotein I 2 2
MIRT706388 MC2R melanocortin 2 receptor 2 2
MIRT707487 UGT2B4 UDP glucuronosyltransferase family 2 member B4 2 2
MIRT711885 INSIG2 insulin induced gene 2 2 2
MIRT719164 KIF6 kinesin family member 6 2 2
MIRT721294 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT721775 ARL6IP4 ADP ribosylation factor like GTPase 6 interacting protein 4 2 2
MIRT723763 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 2
MIRT725485 GPR26 G protein-coupled receptor 26 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miR-4271 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (BGC823)
hsa-miR-4271 Platinum-based doublet chemotherapy sensitive High Lung Adenocarcinoma tissue
hsa-miR-4271 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4271 Fluorouracil 3385 NSC19893 approved sensitive High Pancreatic Cancer cell line (PATU8988)
hsa-miR-4271 Cisplatin 5460033 NSC119875 approved resistant Low Tongue Squamous Cell Carcinoma cell line (CAL-27, SCC-9)
hsa-miR-4271 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (H460)
hsa-miR-4271 Anlotinib 25017411 NSC832523 sensitive Low Non-Small Cell Lung Cancer cell line (A549, PDC, H460)
hsa-miR-4271 Gefitinib 123631 NSC715055 approved sensitive Low Non-Small Cell Lung Cancer cell line (A549, PDC, H460)
hsa-miR-4271 Icotinib 22024915 NSC800770 sensitive Low Non-Small Cell Lung Cancer cell line (A549, PDC, H460)
hsa-miR-4271 Erlotinib 176870 NSC718781 approved sensitive Low Non-Small Cell Lung Cancer cell line (A549, PDC, H460)
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved resistant cell line (W1)
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-4271 Androstenedione+Anastrozole resistant cell line (MCF-7)
hsa-mir-4271 Androstenedione+Letrozole resistant cell line (MCF-7)
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved sensitive cell line (BGC-823)
hsa-miR-4271 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (cytosolic RNA)
hsa-miR-4271 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (total RNA)
hsa-miR-4271 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-4271 Platinum-based doublet chemotherapy sensitive tissue (lung adenocarcinoma)
hsa-miR-4271 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4271 Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-4271 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4271 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-4271 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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