miRTarBase - #MIRT478545


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pre-miRNA Information
pre-miRNA hsa-mir-4776-1   
Genomic Coordinates chr2: 212926257 - 212926336
Description Homo sapiens miR-4776-1 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-4776-2   
Genomic Coordinates chr2: 212926257 - 212926336
Description Homo sapiens miR-4776-2 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4776-3p
Sequence 54| CUUGCCAUCCUGGUCCACUGCAU |76
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1350638372 1 dbSNP
rs1220781023 5 dbSNP
rs1269946481 7 dbSNP
rs547466728 10 dbSNP
rs965980067 11 dbSNP
rs953060487 13 dbSNP
rs982906747 14 dbSNP
rs1028686150 21 dbSNP
rs951447113 23 dbSNP
Putative Targets

Gene Information
Gene Symbol CTNND1   
Synonyms CAS, CTNND, P120CAS, P120CTN, p120, p120(CAS), p120(CTN)
Description catenin delta 1
Transcript NM_001085458   
Other Transcripts NM_001085459 , NM_001085460 , NM_001085461 , NM_001085462 , NM_001085463 , NM_001085464 , NM_001085465 , NM_001085466 , NM_001085467 , NM_001085468 , NM_001085469 , NM_001331   
Expression
Putative miRNA Targets on CTNND1
3'UTR of CTNND1
(miRNA target sites are highlighted)		 
>CTNND1|NM_001085458|3'UTR
   1 CACCACTATCTCCGTTCCATCTGGGCTTATATGTACTTTTATTTTTTGGTGGTGAAATTGACTGATGATTTTCCTTTTTC
  81 TTCGCTGGACTATTGTGCCAACTGCCAGGCTGCCTCCTGCCCTTACAGCCCTAAGTGGCTGCCTTCTTTCCATCAACTCC
 161 CAACTTCTTCCTGTGAAGTTTAATTGTCTCAACGCCTCCCCCTCCCCCATTCCCTCCATTTTTCTCCCAAGAAACCTGAC
 241 TCAATTATTTGCATATTTTGAGAAACTGCTGCAGATTAGTTCTTTTTGCCAGTTTTCCCTGGAACTCCTGGCCTTTTGTG
 321 GAGGGGAGGGATGGAGAGAATAGGAATCTTCACTAGAAGCCGTGGGAAGAATTGGAAGTTACATGCTGTATATGCAATGT
 401 CCAGCAGTCTGATAAACTGACGATTCTTAATCAAGATTTTTTTCCTGATGGGGAAGGGACTTTTATTTTCTTTTAGAGAG
 481 GGGAAAGTGTGAGCTCTTCCCTTATTCCTAATGGCTATTTTTGAAGCAAAGAAGGCCAGCAACATTGGCACATGCCACCT
 561 GGCAAAGGACCCTTGAGTAAGTGAAGGTCTCCTAAAACTGGGATTAAGAAACCTTGCTCTCCTCATCTCCAAGGCAGGGA
 641 CCATCAAGAACCTACAGACTCCATCTCTTCTGCAAGCCTCATGCCAACCCTGGGCTATTGCTGCTGCCCCTTAAACACAG
 721 GCTGTCCTTAACCCACCTCTCCTGCCCTGTGATATGTCTGCTGAGTTGGCCTGGCCATTTCCAAGAGGCTGTAGAAAGGG
 801 GAGAATGTCAAGGAAGACTTTTGGTAGAGAAGGAGCAGAAAGATGTGTTTTTGGGAAGAAGAAGACCTCTAGGAGGAGCT
 881 AGTAGGAATGTACATGAAGCAATTAGTCTGAAACTGGCTTCCCCACTCCCCCGTTTCTCCTTTTCCTATCCTTATAGGCC
 961 TGTCCCTTGCCTCTGCCCTGGATTGGTTGGCAAACTAAAGGACTTGATGTACATAACTCCTGTCCCTTTTCCCTTACAAG
1041 GTGGGGATTGCCCCTGGCTTTGCCTCTTCTTTGTGCCTTTGGCCTGGGGTGCATCTCCTCCCGCCCTTCCATGTGCCTTT
1121 CTTTGCCTCTGCAGTCTCATTTCTCATAATTTTGCAAATTATATTTTGTTGCTTTCTTACCTACTATTGGCCCTAAATAG
1201 CAGAAAGAAGAGAAGTGACCGAGAGAACCTCAGATTCTTCATTGAGGATTGGTATAGCCATGATTTCAGTCATAGCAAGC
1281 TTTTGCTCAACAGCATATGGGTGGGATTTTGCAAAAATCCTATTCTGATGAATCTCAAAGTAAGGCTGGTAAGAGAAGTG
1361 AGTGGTGTGACTCTTACTCCTTAGGTGCCCAGAATTTACCATCATCTCTGAAGGAGTTACAGGGAAGTGGTCTCCCCAAT
1441 TCTCCCCTCCCTCCAGTATTGCCCCCTCTCACTTTAGCATATATTAATTAGCAGGTTGGGCTAGAGAAATCAGCTGCTAT
1521 GCGGGTTGATTATTATTATTATTTCTAATCCTTTTCCTTATTTGCCTTCTACTCCCCTTAATCTAATCTAAAAGCTCTGT
1601 TCCATGCAACTGGAGTTCCTTATCCCTCTCTTCCCCTTCCCTTATATATTGAGGCTATGGGGTAGGAGAAAAGTGCACAA
1681 CCCACCACCCCCTTTACTCGTGCATTAAAATTTCTTATTTACCCTTTTCCCCCTTCCCATTTCTTCCCACTTTCATCTAC
1761 CTTTTCTGGCAAAAAGGAGCCTTTTGCTCTCTGTGACCCTAAGAGCACACTGCACAGGGAAAATTGCCCCATCCAGACCT
1841 GGCTCCACTCTTGATCTCTCTTGTCCTCTTCTGCTCTTTTCCTGGTGCTCTTTTTTCTCGGTGGGGTGTGGGTAATAGAA
1921 CAGCCGTGGGCTTTTGGGGACCTTTAACTTTTTTTTCTCTCTTTTGTTTATAAAAAACACTAAACATTCAATTCCAGAGA
2001 ACCAAAAATCCCACCTTCCCACCGAACACTACTAAGGGGCTTGTGTTCTGCTCCATACCTTTTCTCTTTTCTTTCTGTCT
2081 TGTTAATGCTTTTAAAAACAAATGAGTTTTTTATATAAATAAAGTTTTTAAAGTGTGTATGTGGGGGGTCTGTGTCATTT
2161 CTTCACTTCAAGCTGTTATTTCTTCCCTGCTTTGCATCTTTGTTACTTCCTTATGTATCAGTGTCCTTTCCAGAGCAACC
2241 AGAAGGAGGTTATACCAGGATTTATTTTGAGCTCAGCCCCAACTCTTTATCAAGCAACATTCTTGTTAACTATATGTGAA
2321 ACATTTTTTCTTCTGAAGATTCTTAAAAATTGAATGTGGCTGAAGTTGAACATGGGAGCTTATTGCTAATTTAGAGATAG
2401 GAAACTGAAGCATAAAGAATTAATGACTTACTTTAATTACTGGAATTCTTCTGCAACATTTGACAAAACTAACCTTGAAT
2481 AAGGCCCACTGTAATACGTAGCTCTCTTAAATATAACACTTAGGACTAGAAGATTAGAAACTACCAATCCCAACTACGTA
2561 ATAGGAAAATGTAGGATCAAAAGGCCCATGTATATAAGTACTGACCACTGGGCCATAATGTTGCTTCTCAGGCTATATGC
2641 AGTCCTTTAGTCAGAAGTCAATAGGCCTATTTATTAATATTTTACAGACCATATTACCTGGATTACCAGGGACTATCTTT
2721 GCTGCAGAGATCAAGGGTTAAGATCTATGGGAAGATACTTATTTTTCTGAGGTCCTTATGTCCTGTCATATAATTAAAGA
2801 CTCAAGAGAATTTATGTGAAATGCTTTCTGTATGCCCAAATCTTTAGATTAAAATTATATAGCTGCTCCTGAAAAAAAAA
2881 AAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uaCGUCACCUGGUCCUACCGUUc 5'
            ||  ||||:: || |||||| 
Target 5' ctGCCCTGGATT-GGTTGGCAAa 3'
 973 - 994 136.00 -18.30
2 
miRNA  3' uaCGUCACCUGGUCC----UACCGUUc 5'
            || || ||  :||    ||| ||| 
Target 5' agGCTGTAGAAAGGGGAGAATGTCAAg 3'
 786 - 812 123.00 -12.80
3 
miRNA  3' uacGUCACCUGGUCC----UACCGUUc 5'
             || |||  || |     |||||| 
Target 5' caaCATTGGCACATGCCACCTGGCAAa 3'
 540 - 566 122.00 -11.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN23023129 13 COSMIC
COSN13332431 14 COSMIC
COSN30104033 26 COSMIC
COSN20698183 32 COSMIC
COSN31595880 40 COSMIC
COSN30513117 44 COSMIC
COSN30107046 52 COSMIC
COSN28690201 81 COSMIC
COSN30170711 147 COSMIC
COSN30516392 155 COSMIC
COSN507801 194 COSMIC
COSN30162835 205 COSMIC
COSN30160079 217 COSMIC
COSN31578268 263 COSMIC
COSN28758009 308 COSMIC
COSN28757712 309 COSMIC
COSN32056479 363 COSMIC
COSN31535368 379 COSMIC
COSN7014808 411 COSMIC
COSN30175605 444 COSMIC
COSN31522312 679 COSMIC
COSN20574025 719 COSMIC
COSN31483804 743 COSMIC
COSN26640999 894 COSMIC
COSN8281950 1074 COSMIC
COSN24303668 1381 COSMIC
COSN20092350 1401 COSMIC
COSN1538783 1420 COSMIC
COSN31533943 1452 COSMIC
COSN30540763 1471 COSMIC
COSN28646289 1502 COSMIC
COSN15662316 1558 COSMIC
COSN31483211 1579 COSMIC
COSN8685258 1687 COSMIC
COSN31580028 1714 COSMIC
COSN30177284 1767 COSMIC
COSN30164387 1792 COSMIC
COSN31482334 1797 COSMIC
COSN30172393 1882 COSMIC
COSN28705044 1883 COSMIC
COSN7014809 2005 COSMIC
COSN22614782 2318 COSMIC
COSN29750675 2551 COSMIC
COSN27756350 2768 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs765263826 4 dbSNP
rs750319940 6 dbSNP
rs1327632452 11 dbSNP
rs757867202 14 dbSNP
rs779575280 15 dbSNP
rs11570226 22 dbSNP
rs1445449924 28 dbSNP
rs754635759 29 dbSNP
rs11570227 32 dbSNP
rs1278794637 34 dbSNP
rs1490132091 36 dbSNP
rs539941825 40 dbSNP
rs774849647 49 dbSNP
rs746328613 50 dbSNP
rs1329204636 59 dbSNP
rs1276911141 64 dbSNP
rs910534533 66 dbSNP
rs1325445904 69 dbSNP
rs1378635754 74 dbSNP
rs1231501476 81 dbSNP
rs1401295834 84 dbSNP
rs374037566 85 dbSNP
rs777671880 86 dbSNP
rs1435197705 90 dbSNP
rs1427213619 107 dbSNP
rs966455984 110 dbSNP
rs1474985494 121 dbSNP
rs976160394 141 dbSNP
rs1194723433 144 dbSNP
rs1489308395 157 dbSNP
rs557830271 161 dbSNP
rs1235250094 164 dbSNP
rs566866056 168 dbSNP
rs1210267519 174 dbSNP
rs919339299 180 dbSNP
rs929447586 182 dbSNP
rs1213144474 189 dbSNP
rs984916982 194 dbSNP
rs534181698 195 dbSNP
rs1448167207 198 dbSNP
rs527340024 198 dbSNP
rs909414635 198 dbSNP
rs1044640823 203 dbSNP
rs904821407 205 dbSNP
rs746750419 209 dbSNP
rs1172556412 210 dbSNP
rs1420044710 210 dbSNP
rs1056170645 213 dbSNP
rs11229141 215 dbSNP
rs186461637 220 dbSNP
rs1187260410 221 dbSNP
rs1193125346 224 dbSNP
rs1483642056 230 dbSNP
rs1253645492 231 dbSNP
rs1471891512 242 dbSNP
rs892200743 245 dbSNP
rs1203118872 252 dbSNP
rs1009345934 275 dbSNP
rs1259043473 293 dbSNP
rs1168866328 299 dbSNP
rs1332171767 302 dbSNP
rs1022116178 304 dbSNP
rs1228375080 309 dbSNP
rs1380785300 311 dbSNP
rs1277696182 319 dbSNP
rs903709531 327 dbSNP
rs1373000734 328 dbSNP
rs1400954219 330 dbSNP
rs1462866628 334 dbSNP
rs1459707280 335 dbSNP
rs1392513776 336 dbSNP
rs12223213 349 dbSNP
rs1164406888 362 dbSNP
rs556094250 363 dbSNP
rs1402070788 367 dbSNP
rs1175572200 370 dbSNP
rs1438209630 383 dbSNP
rs1324651073 384 dbSNP
rs1371008674 389 dbSNP
rs11570228 393 dbSNP
rs966033923 394 dbSNP
rs1467457265 396 dbSNP
rs1272138119 400 dbSNP
rs551976857 407 dbSNP
rs878869453 408 dbSNP
rs879166251 409 dbSNP
rs879088732 410 dbSNP
rs570671539 412 dbSNP
rs544806382 413 dbSNP
rs950848934 422 dbSNP
rs1213233281 423 dbSNP
rs984859591 426 dbSNP
rs909356000 436 dbSNP
rs948896445 444 dbSNP
rs980282948 445 dbSNP
rs61888912 446 dbSNP
rs1370051183 449 dbSNP
rs879183273 453 dbSNP
rs1458553415 458 dbSNP
rs190992378 461 dbSNP
rs928876825 474 dbSNP
rs1156964004 476 dbSNP
rs1419222282 478 dbSNP
rs1381453754 482 dbSNP
rs938978986 484 dbSNP
rs1452961087 490 dbSNP
rs577636534 496 dbSNP
rs1184840413 497 dbSNP
rs1261698347 498 dbSNP
rs1489227160 500 dbSNP
rs1258614308 506 dbSNP
rs892152405 508 dbSNP
rs1429595346 511 dbSNP
rs1196338347 516 dbSNP
rs1353859656 522 dbSNP
rs1288058135 523 dbSNP
rs1232077673 543 dbSNP
rs1347080486 545 dbSNP
rs1301661624 559 dbSNP
rs945086872 567 dbSNP
rs1416080580 578 dbSNP
rs1043510825 589 dbSNP
rs117164520 590 dbSNP
rs1182000381 592 dbSNP
rs1361328456 593 dbSNP
rs1160540311 594 dbSNP
rs1163843774 600 dbSNP
rs1007402803 603 dbSNP
rs1433337052 603 dbSNP
rs1177187200 613 dbSNP
rs1017478695 616 dbSNP
rs1259203421 617 dbSNP
rs1350093447 618 dbSNP
rs1488328226 623 dbSNP
rs1264639192 624 dbSNP
rs967122790 639 dbSNP
rs901751188 640 dbSNP
rs770951427 644 dbSNP
rs1485281608 653 dbSNP
rs997471761 658 dbSNP
rs1235119107 660 dbSNP
rs780980659 666 dbSNP
rs770145462 667 dbSNP
rs1218179852 668 dbSNP
rs984805537 679 dbSNP
rs1300059680 681 dbSNP
rs1413043248 696 dbSNP
rs1402077578 697 dbSNP
rs1361220255 708 dbSNP
rs1467888603 710 dbSNP
rs1371768031 714 dbSNP
rs866763652 720 dbSNP
rs1170415324 725 dbSNP
rs1016303828 728 dbSNP
rs1425370535 730 dbSNP
rs1382660285 740 dbSNP
rs559854671 741 dbSNP
rs1279878626 753 dbSNP
rs1441388964 764 dbSNP
rs1256765911 778 dbSNP
rs1353262782 785 dbSNP
rs527275670 790 dbSNP
rs1202178433 804 dbSNP
rs1479621810 807 dbSNP
rs774354414 819 dbSNP
rs1413078448 828 dbSNP
rs1318820124 838 dbSNP
rs1232456130 843 dbSNP
rs980230664 846 dbSNP
rs1274107764 855 dbSNP
rs1340006554 855 dbSNP
rs1323710179 861 dbSNP
rs1394983703 865 dbSNP
rs1331053838 868 dbSNP
rs1466506326 871 dbSNP
rs749389557 877 dbSNP
rs1260179508 887 dbSNP
rs928846401 890 dbSNP
rs753308361 895 dbSNP
rs1368475407 903 dbSNP
rs1219345287 905 dbSNP
rs1256019162 914 dbSNP
rs1189038508 915 dbSNP
rs1475117940 925 dbSNP
rs1237522348 930 dbSNP
rs542254707 933 dbSNP
rs560833297 934 dbSNP
rs11570229 949 dbSNP
rs181691897 955 dbSNP
rs1247124887 956 dbSNP
rs1309237564 957 dbSNP
rs1447968437 976 dbSNP
rs1379667284 977 dbSNP
rs1324311342 982 dbSNP
rs749632859 992 dbSNP
rs1057299 999 dbSNP
rs1391035766 1003 dbSNP
rs1344029598 1007 dbSNP
rs571123161 1008 dbSNP
rs1043458637 1015 dbSNP
rs1441309486 1019 dbSNP
rs1250833872 1020 dbSNP
rs1420240668 1038 dbSNP
rs1197919331 1044 dbSNP
rs1451203196 1051 dbSNP
rs1300035188 1053 dbSNP
rs1268370136 1074 dbSNP
rs1373546981 1077 dbSNP
rs1351675517 1084 dbSNP
rs1413995413 1090 dbSNP
rs533226518 1103 dbSNP
rs943134784 1104 dbSNP
rs1356489027 1118 dbSNP
rs1381660739 1118 dbSNP
rs1039266698 1131 dbSNP
rs1436240866 1132 dbSNP
rs901700254 1133 dbSNP
rs1325170428 1137 dbSNP
rs1380011135 1144 dbSNP
rs1359415861 1148 dbSNP
rs773049895 1154 dbSNP
rs868845502 1163 dbSNP
rs997813978 1164 dbSNP
rs1421379048 1165 dbSNP
rs551858779 1173 dbSNP
rs1393218520 1175 dbSNP
rs1171748808 1187 dbSNP
rs1803000 1211 dbSNP
rs1047647464 1219 dbSNP
rs186908303 1221 dbSNP
rs774577889 1222 dbSNP
rs1201369333 1230 dbSNP
rs1306402947 1244 dbSNP
rs1317664107 1252 dbSNP
rs555276151 1254 dbSNP
rs760372736 1255 dbSNP
rs1217471069 1258 dbSNP
rs770632780 1259 dbSNP
rs11538288 1265 dbSNP
rs1485612173 1274 dbSNP
rs1277163825 1280 dbSNP
rs970100688 1287 dbSNP
rs1001648704 1298 dbSNP
rs1276242689 1302 dbSNP
rs1057318 1311 dbSNP
rs139535448 1323 dbSNP
rs1298221733 1330 dbSNP
rs960250933 1333 dbSNP
rs1373532336 1335 dbSNP
rs989437130 1338 dbSNP
rs1414822256 1342 dbSNP
rs149696944 1346 dbSNP
rs969000193 1365 dbSNP
rs1484034653 1366 dbSNP
rs761982463 1368 dbSNP
rs979085929 1371 dbSNP
rs924970633 1379 dbSNP
rs865866108 1401 dbSNP
rs555834652 1403 dbSNP
rs1478869378 1404 dbSNP
rs1236214030 1412 dbSNP
rs1210113321 1413 dbSNP
rs1175054748 1416 dbSNP
rs1406790188 1421 dbSNP
rs772246435 1430 dbSNP
rs943082440 1434 dbSNP
rs1038801779 1440 dbSNP
rs759530385 1445 dbSNP
rs1219921247 1448 dbSNP
rs933170095 1453 dbSNP
rs773612279 1457 dbSNP
rs1283095131 1460 dbSNP
rs1048060493 1469 dbSNP
rs1360852508 1480 dbSNP
rs886348976 1488 dbSNP
rs767401861 1490 dbSNP
rs1393239953 1499 dbSNP
rs567938638 1502 dbSNP
rs1399804275 1511 dbSNP
rs1006122254 1512 dbSNP
rs1037646448 1518 dbSNP
rs777718033 1522 dbSNP
rs760932139 1523 dbSNP
rs753895296 1524 dbSNP
rs1035788532 1526 dbSNP
rs1439746588 1529 dbSNP
rs1457645848 1529 dbSNP
rs148878219 1532 dbSNP
rs1200067724 1537 dbSNP
rs1319570290 1541 dbSNP
rs1288469582 1557 dbSNP
rs1228432907 1563 dbSNP
rs1010403415 1568 dbSNP
rs1307050069 1603 dbSNP
rs1445750969 1612 dbSNP
rs762684828 1620 dbSNP
rs556761258 1625 dbSNP
rs1242454747 1626 dbSNP
rs1377448723 1640 dbSNP
rs377290495 1641 dbSNP
rs1347813609 1646 dbSNP
rs968947887 1675 dbSNP
rs1164123758 1679 dbSNP
rs1406065070 1682 dbSNP
rs1387616181 1683 dbSNP
rs199753875 1691 dbSNP
rs1439629733 1692 dbSNP
rs1057428 1695 dbSNP
rs1239109995 1697 dbSNP
rs1180927202 1700 dbSNP
rs979032119 1701 dbSNP
rs1245815015 1704 dbSNP
rs1031987772 1709 dbSNP
rs553821060 1716 dbSNP
rs1306194263 1719 dbSNP
rs572080634 1723 dbSNP
rs974859060 1726 dbSNP
rs1311117797 1733 dbSNP
rs923041823 1734 dbSNP
rs933099104 1735 dbSNP
rs983289675 1745 dbSNP
rs757443397 1755 dbSNP
rs763850703 1756 dbSNP
rs1367456329 1758 dbSNP
rs866761206 1770 dbSNP
rs1296437785 1771 dbSNP
rs542193925 1777 dbSNP
rs907736230 1778 dbSNP
rs1161698532 1788 dbSNP
rs941926287 1790 dbSNP
rs1037592618 1791 dbSNP
rs1453739180 1794 dbSNP
rs905839916 1799 dbSNP
rs1489258977 1800 dbSNP
rs937363716 1810 dbSNP
rs1488552648 1818 dbSNP
rs1427164555 1820 dbSNP
rs1408047427 1830 dbSNP
rs1057451903 1843 dbSNP
rs1401339868 1846 dbSNP
rs895894283 1855 dbSNP
rs1449210845 1858 dbSNP
rs1276343393 1859 dbSNP
rs1399523077 1870 dbSNP
rs560570115 1875 dbSNP
rs708228 1883 dbSNP
rs1020447386 1891 dbSNP
rs543319855 1896 dbSNP
rs1177259214 1898 dbSNP
rs1437280689 1900 dbSNP
rs1421057487 1901 dbSNP
rs1192262353 1902 dbSNP
rs1477889699 1904 dbSNP
rs1277180336 1905 dbSNP
rs557678358 1907 dbSNP
rs1018539734 1911 dbSNP
rs1214392594 1912 dbSNP
rs1256321179 1915 dbSNP
rs1212015079 1921 dbSNP
rs1325890927 1922 dbSNP
rs1276600269 1924 dbSNP
rs964684716 1926 dbSNP
rs757461029 1927 dbSNP
rs1297817127 1940 dbSNP
rs974426501 1943 dbSNP
rs1030439407 1946 dbSNP
rs1471183009 1947 dbSNP
rs1397647163 1953 dbSNP
rs1169591984 1956 dbSNP
rs1465822443 1956 dbSNP
rs1200076023 1958 dbSNP
rs954466397 1966 dbSNP
rs1184807166 1971 dbSNP
rs1467686001 1978 dbSNP
rs1423135459 1979 dbSNP
rs1256829608 1980 dbSNP
rs1185179916 1986 dbSNP
rs1456323013 1987 dbSNP
rs1256398943 1989 dbSNP
rs375471831 1992 dbSNP
rs907682238 1993 dbSNP
rs1802998 1994 dbSNP
rs529542270 2004 dbSNP
rs1057812 2005 dbSNP
rs879340883 2009 dbSNP
rs746043180 2013 dbSNP
rs3208904 2014 dbSNP
rs1185734348 2015 dbSNP
rs3208905 2022 dbSNP
rs1314125818 2023 dbSNP
rs547318191 2024 dbSNP
rs560622515 2025 dbSNP
rs1467380042 2027 dbSNP
rs927212890 2041 dbSNP
rs1331116497 2043 dbSNP
rs1394015847 2048 dbSNP
rs1447001822 2048 dbSNP
rs1398225172 2054 dbSNP
rs1160922172 2056 dbSNP
rs1457016728 2058 dbSNP
rs141266914 2062 dbSNP
rs374777978 2062 dbSNP
rs533874860 2062 dbSNP
rs1325576425 2064 dbSNP
rs200470100 2065 dbSNP
rs145936146 2068 dbSNP
rs191445639 2068 dbSNP
rs1430584775 2091 dbSNP
rs1279250512 2102 dbSNP
rs1208112659 2107 dbSNP
rs1342695531 2107 dbSNP
rs895830133 2107 dbSNP
rs549370766 2125 dbSNP
rs1248733366 2130 dbSNP
rs1041838226 2138 dbSNP
rs1241382067 2142 dbSNP
rs566382958 2143 dbSNP
rs796299996 2143 dbSNP
rs1000362299 2145 dbSNP
rs1010740808 2149 dbSNP
rs11570231 2149 dbSNP
rs1209942843 2151 dbSNP
rs1039928064 2165 dbSNP
rs1304440908 2177 dbSNP
rs1417728118 2185 dbSNP
rs1379644129 2214 dbSNP
rs1158991304 2220 dbSNP
rs754234254 2222 dbSNP
rs768484373 2238 dbSNP
rs1197110118 2241 dbSNP
rs1445220355 2243 dbSNP
rs1029972628 2253 dbSNP
rs963958283 2256 dbSNP
rs1215720007 2265 dbSNP
rs1263805256 2272 dbSNP
rs578043083 2278 dbSNP
rs1487575386 2283 dbSNP
rs145411496 2298 dbSNP
rs951040166 2301 dbSNP
rs1353371860 2302 dbSNP
rs1473227799 2303 dbSNP
rs1014631754 2304 dbSNP
rs963139752 2307 dbSNP
rs1284604905 2310 dbSNP
rs1350832285 2312 dbSNP
rs1397640771 2323 dbSNP
rs549697763 2324 dbSNP
rs1298798067 2333 dbSNP
rs146530142 2335 dbSNP
rs982531616 2343 dbSNP
rs1399712779 2348 dbSNP
rs909634243 2366 dbSNP
rs183357386 2376 dbSNP
rs1362981456 2378 dbSNP
rs927149595 2380 dbSNP
rs1263093367 2383 dbSNP
rs1217045449 2384 dbSNP
rs1413365670 2389 dbSNP
rs868050698 2391 dbSNP
rs1200275461 2406 dbSNP
rs1312609568 2407 dbSNP
rs756678483 2410 dbSNP
rs958631861 2411 dbSNP
rs141112843 2418 dbSNP
rs916831224 2421 dbSNP
rs543600910 2437 dbSNP
rs1339362634 2440 dbSNP
rs752647104 2446 dbSNP
rs1432738052 2452 dbSNP
rs948307137 2455 dbSNP
rs946039502 2459 dbSNP
rs1414873534 2465 dbSNP
rs1041779353 2482 dbSNP
rs926019327 2485 dbSNP
rs1464264901 2487 dbSNP
rs1238770107 2498 dbSNP
rs1187204479 2499 dbSNP
rs749792228 2502 dbSNP
rs906563243 2508 dbSNP
rs999517926 2510 dbSNP
rs769183429 2513 dbSNP
rs1187257143 2514 dbSNP
rs1208506311 2515 dbSNP
rs1039877058 2517 dbSNP
rs145013935 2525 dbSNP
rs1255160862 2548 dbSNP
rs893854432 2551 dbSNP
rs1443229740 2554 dbSNP
rs1215856250 2558 dbSNP
rs1354139351 2561 dbSNP
rs1189801171 2568 dbSNP
rs900015968 2576 dbSNP
rs1010750543 2585 dbSNP
rs1469743753 2587 dbSNP
rs1159295366 2593 dbSNP
rs1051789974 2595 dbSNP
rs554099518 2598 dbSNP
rs1433346115 2610 dbSNP
rs1354201253 2615 dbSNP
rs1018076729 2616 dbSNP
rs572079200 2622 dbSNP
rs1403269419 2624 dbSNP
rs535954662 2636 dbSNP
rs1412250257 2640 dbSNP
rs1163258166 2645 dbSNP
rs964322238 2648 dbSNP
rs1245291318 2649 dbSNP
rs552021429 2653 dbSNP
rs554102105 2655 dbSNP
rs1205989277 2658 dbSNP
rs1233148323 2658 dbSNP
rs1449439696 2660 dbSNP
rs1288530378 2662 dbSNP
rs11570232 2663 dbSNP
rs543062674 2670 dbSNP
rs1306753221 2676 dbSNP
rs1239214682 2677 dbSNP
rs963086305 2685 dbSNP
rs1445457544 2688 dbSNP
rs1299019450 2692 dbSNP
rs951092491 2694 dbSNP
rs1444460009 2695 dbSNP
rs982374692 2698 dbSNP
rs1309308697 2702 dbSNP
rs1302644182 2703 dbSNP
rs1425794141 2706 dbSNP
rs1387678387 2707 dbSNP
rs994571533 2714 dbSNP
rs1016647985 2716 dbSNP
rs1408257894 2717 dbSNP
rs746716302 2726 dbSNP
rs77817107 2728 dbSNP
rs1231920527 2734 dbSNP
rs1255200723 2737 dbSNP
rs187805437 2751 dbSNP
rs1201950535 2752 dbSNP
rs1248732854 2755 dbSNP
rs1222621389 2756 dbSNP
rs1457451815 2756 dbSNP
rs1490812536 2762 dbSNP
rs1283863216 2763 dbSNP
rs1215615227 2765 dbSNP
rs1179360538 2773 dbSNP
rs1308887109 2774 dbSNP
rs1240040666 2781 dbSNP
rs1453118451 2784 dbSNP
rs973998896 2786 dbSNP
rs916777953 2791 dbSNP
rs1282680524 2800 dbSNP
rs11570233 2804 dbSNP
rs750371148 2804 dbSNP
rs541201168 2806 dbSNP
rs948205696 2807 dbSNP
rs1367987356 2811 dbSNP
rs559306779 2822 dbSNP
rs1467942577 2832 dbSNP
rs717565 2833 dbSNP
rs1453677896 2837 dbSNP
rs1346096612 2838 dbSNP
rs1057939 2839 dbSNP
rs928198610 2840 dbSNP
rs1166488822 2844 dbSNP
rs1161760344 2846 dbSNP
rs1393924366 2848 dbSNP
rs1412356931 2848 dbSNP
rs935319730 2854 dbSNP
rs1260935077 2859 dbSNP
rs967322161 2878 dbSNP
rs1052398486 2881 dbSNP
rs1262224094 2883 dbSNP
rs1207795901 2889 dbSNP
rs1331460914 2904 dbSNP
rs1262819117 2911 dbSNP
rs1224197237 2914 dbSNP
rs1347398052 2918 dbSNP
rs925965579 2924 dbSNP
rs936045893 2928 dbSNP
rs893906476 2933 dbSNP
rs946796619 2939 dbSNP
rs1290964656 2944 dbSNP
rs1378392741 2951 dbSNP
rs1404890052 2951 dbSNP
rs1176797905 2968 dbSNP
rs1470756551 2971 dbSNP
rs770431673 2986 dbSNP
rs1300577635 2987 dbSNP
rs1331588418 2990 dbSNP
rs1205011597 3003 dbSNP
rs1179887786 3017 dbSNP
rs776208013 3022 dbSNP
rs1235183920 3026 dbSNP
rs191078355 3038 dbSNP
rs1317532513 3047 dbSNP
rs1204482690 3052 dbSNP
rs998427449 3053 dbSNP
rs1325950529 3054 dbSNP
rs1256190960 3057 dbSNP
rs1226830296 3059 dbSNP
rs1199431791 3065 dbSNP
rs758927948 3070 dbSNP
rs1394653795 3071 dbSNP
rs886993274 3072 dbSNP
rs1337819667 3077 dbSNP
rs1467240717 3079 dbSNP
rs1190658013 3081 dbSNP
rs1454206629 3082 dbSNP
rs1397714647 3118 dbSNP
rs1268710757 3122 dbSNP
rs921405651 3125 dbSNP
rs1462101792 3131 dbSNP
rs1435387597 3142 dbSNP
rs1374720249 3144 dbSNP
rs1003847229 3146 dbSNP
rs1051311319 3148 dbSNP
rs1385576090 3149 dbSNP
rs1016532997 3160 dbSNP
rs1423291870 3165 dbSNP
rs940307806 3169 dbSNP
rs1035969758 3172 dbSNP
rs750822390 3173 dbSNP
rs537179111 3183 dbSNP
rs1171034222 3186 dbSNP
rs549509025 3187 dbSNP
rs1243183663 3192 dbSNP
rs962335897 3196 dbSNP
rs1359383518 3198 dbSNP
rs1402006214 3206 dbSNP
rs991282009 3208 dbSNP
rs561221916 3216 dbSNP
rs898854175 3227 dbSNP
rs1023127406 3230 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_001085467 | 3UTR | AACAUUGGCACAUGCCACCUGGCAAAGGACCCUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_001206888 | 3UTR | CAGCAACAUUGGCACAUGCCACCUGGCAAAGGACCCUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_001085467 | 3UTR | AGAAGGCCAGCAACAUUGGCACAUGCCACCUGGCAAAGGACCCUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_001085467 | 3UTR | AUGCCACCUGGCAAAGGACCCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000524630.1 | 3UTR | CUUCCCACUUUCAUCUACCUUUUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
104 hsa-miR-4776-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT107576 VLDLR very low density lipoprotein receptor 2 2
MIRT183601 SNRPE small nuclear ribonucleoprotein polypeptide E 2 4
MIRT208901 PDCD10 programmed cell death 10 2 2
MIRT441496 IFFO2 intermediate filament family orphan 2 2 2
MIRT441590 PSTK phosphoseryl-tRNA kinase 2 2
MIRT441865 RNASEL ribonuclease L 2 2
MIRT442155 DPY19L1 dpy-19 like C-mannosyltransferase 1 2 2
MIRT442235 DDX19A DEAD-box helicase 19A 2 2
MIRT442519 MOB3B MOB kinase activator 3B 2 2
MIRT443347 STX7 syntaxin 7 2 2
MIRT443598 ZNF91 zinc finger protein 91 2 2
MIRT443725 USP14 ubiquitin specific peptidase 14 2 2
MIRT453650 RAB6C RAB6C, member RAS oncogene family 2 2
MIRT464155 VMP1 vacuole membrane protein 1 2 11
MIRT472507 NACC1 nucleus accumbens associated 1 2 4
MIRT476018 GTF2A1 general transcription factor IIA subunit 1 2 2
MIRT477716 EEF1A1 eukaryotic translation elongation factor 1 alpha 1 2 2
MIRT478545 CTNND1 catenin delta 1 2 2
MIRT481629 ARF1 ADP ribosylation factor 1 2 2
MIRT486451 MDM2 MDM2 proto-oncogene 2 2
MIRT494856 ZNF99 zinc finger protein 99 2 4
MIRT495096 FXR1 FMR1 autosomal homolog 1 2 2
MIRT495766 ZNF546 zinc finger protein 546 2 2
MIRT496650 PITPNM3 PITPNM family member 3 2 2
MIRT496920 CLMN calmin 2 2
MIRT496997 SNAP25 synaptosome associated protein 25 2 2
MIRT497056 C6orf223 chromosome 6 open reading frame 223 2 2
MIRT498391 KIF6 kinesin family member 6 2 2
MIRT499057 CTBP1 C-terminal binding protein 1 2 4
MIRT499093 DENND4C DENN domain containing 4C 2 8
MIRT499860 SVOP SV2 related protein 2 12
MIRT501968 MAPK6 mitogen-activated protein kinase 6 2 2
MIRT504910 CD38 CD38 molecule 2 4
MIRT506781 KLHL15 kelch like family member 15 2 6
MIRT509549 ACTG1 actin gamma 1 2 4
MIRT510814 SBNO1 strawberry notch homolog 1 2 4
MIRT515490 NTRK3 neurotrophic receptor tyrosine kinase 3 2 4
MIRT517752 ZNF366 zinc finger protein 366 2 4
MIRT518553 GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 2 2
MIRT518633 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT518721 ABCG8 ATP binding cassette subfamily G member 8 2 2
MIRT524469 CHRM3 cholinergic receptor muscarinic 3 2 4
MIRT525213 ZNF253 zinc finger protein 253 2 2
MIRT527556 ADCY7 adenylate cyclase 7 2 2
MIRT532691 TCN2 transcobalamin 2 2 4
MIRT533124 YES1 YES proto-oncogene 1, Src family tyrosine kinase 2 2
MIRT534080 SPRY4 sprouty RTK signaling antagonist 4 2 2
MIRT534437 SDR16C5 short chain dehydrogenase/reductase family 16C member 5 2 2
MIRT534997 PRPF40A pre-mRNA processing factor 40 homolog A 2 4
MIRT537160 GGCX gamma-glutamyl carboxylase 2 2
MIRT539359 AFF4 AF4/FMR2 family member 4 2 2
MIRT547019 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT550122 ZNF138 zinc finger protein 138 2 2
MIRT558471 DBN1 drebrin 1 2 2
MIRT563055 ZNF28 zinc finger protein 28 2 2
MIRT563550 SCP2 sterol carrier protein 2 2 2
MIRT566860 LRRC58 leucine rich repeat containing 58 2 2
MIRT567239 HSPA13 heat shock protein family A (Hsp70) member 13 2 2
MIRT572846 BRPF3 bromodomain and PHD finger containing 3 2 2
MIRT573355 PDE3A phosphodiesterase 3A 2 2
MIRT573761 PRKAG1 protein kinase AMP-activated non-catalytic subunit gamma 1 2 2
MIRT574911 Vmp1 vacuole membrane protein 1 2 7
MIRT610172 SEC14L4 SEC14 like lipid binding 4 2 2
MIRT611271 RBMXL1 RNA binding motif protein, X-linked like 1 2 2
MIRT612325 TRPS1 transcriptional repressor GATA binding 1 2 2
MIRT612720 NOL4 nucleolar protein 4 2 2
MIRT613093 ETS1 ETS proto-oncogene 1, transcription factor 2 2
MIRT613759 RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 2 2
MIRT614788 RRAGC Ras related GTP binding C 2 2
MIRT614926 MARCH3 membrane associated ring-CH-type finger 3 2 2
MIRT616777 CD44 CD44 molecule (Indian blood group) 2 2
MIRT616892 DUSP1 dual specificity phosphatase 1 2 2
MIRT618446 SERPINA3 serpin family A member 3 2 2
MIRT619155 PPDPF pancreatic progenitor cell differentiation and proliferation factor 2 2
MIRT619271 CEP57L1 centrosomal protein 57 like 1 2 2
MIRT620899 MUT methylmalonyl-CoA mutase 2 2
MIRT621151 MICALCL MICAL C-terminal like 2 2
MIRT622138 SOX4 SRY-box 4 2 2
MIRT622925 PAK7 p21 (RAC1) activated kinase 5 2 2
MIRT623595 IPO9 importin 9 2 2
MIRT623916 FNBP1L formin binding protein 1 like 2 2
MIRT624072 EBF1 early B-cell factor 1 2 2
MIRT630961 NGDN neuroguidin 2 2
MIRT636738 ADD3 adducin 3 2 2
MIRT639788 MVK mevalonate kinase 2 2
MIRT641106 ZNF274 zinc finger protein 274 2 2
MIRT641573 RFX1 regulatory factor X1 2 2
MIRT643089 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT646457 PRDM10 PR/SET domain 10 2 2
MIRT653068 ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2 2
MIRT657672 GPR26 G protein-coupled receptor 26 2 2
MIRT660287 BICC1 BicC family RNA binding protein 1 2 2
MIRT660354 BAG4 BCL2 associated athanogene 4 2 2
MIRT665823 TIMM8B translocase of inner mitochondrial membrane 8 homolog B 2 2
MIRT678564 ZNF786 zinc finger protein 786 2 2
MIRT691520 ZNF208 zinc finger protein 208 2 2
MIRT695586 TMEM199 transmembrane protein 199 2 2
MIRT698033 TRPM7 transient receptor potential cation channel subfamily M member 7 2 2
MIRT701012 PCGF5 polycomb group ring finger 5 2 2
MIRT701353 NR4A3 nuclear receptor subfamily 4 group A member 3 2 2
MIRT704846 CD55 CD55 molecule (Cromer blood group) 2 2
MIRT707112 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT718656 HNF4A hepatocyte nuclear factor 4 alpha 2 2
MIRT720561 C1RL complement C1r subcomponent like 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4776-3p Paclitaxel 36314 NSC125973 approved resistant High Breast Cancer cell line (Bads-200, Bats-72, BCap37)
hsa-miR-4776-3p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780CIS)
hsa-miR-4776-3p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780CP20)
hsa-miR-4776-3p Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-miR-4776-3p Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-4776-3p Neoadjuvant chemotherapy resistant tissue (breast cancer)

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