miRTarBase - #MIRT478586


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pre-miRNA Information
pre-miRNA hsa-mir-383   
Genomic Coordinates chr8: 14853438 - 14853510
Synonyms MIRN383, hsa-mir-383, MIR383
Description Homo sapiens miR-383 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-383-5p
Sequence 7| AGAUCAGAAGGUGAUUGUGGCU |28
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN26994512 7 COSMIC
COSN30109318 22 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs112302475 1 dbSNP
rs756858316 1 dbSNP
rs757040124 3 dbSNP
rs1419085595 4 dbSNP
rs912771170 5 dbSNP
rs1190491141 6 dbSNP
rs986831934 7 dbSNP
rs1471946963 9 dbSNP
rs1237080909 10 dbSNP
rs757526216 11 dbSNP
rs1431645579 13 dbSNP
rs763747200 13 dbSNP
rs184836993 15 dbSNP
rs913343525 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CTDSPL2   
Synonyms HSPC058, HSPC129
Description CTD small phosphatase like 2
Transcript NM_016396   
Expression
Putative miRNA Targets on CTDSPL2
3'UTR of CTDSPL2
(miRNA target sites are highlighted)		 
>CTDSPL2|NM_016396|3'UTR
   1 GTACAAAGACTTGTCAAATCACTGAAGGGGGAGAGAATGCAGGACCCTTTTGGACTAAGACAAAAACATTGCCATTACTG
  81 TTGAAATTTTGCATTTTTGTACCCCGTCTTGCTTTTCTTATCTTTGGTGCCCAATAATAATTAAGGGTTACAGAAAGAGA
 161 CTTTATCTATCTCAGATCGAATACATATAGTAGGTAGGCTAAAACAGAAGAGTCTTTAGAACTAGTGCAACTCCAGTGAA
 241 ATTTTTTATGTACAGGACATCTGCAGTTTATAAAGAATTCTGTTTCTGCCACCAGCAGTTTGACCTGTAGTCACACAGGA
 321 TTTTATGATAATAACAGAGATGAAAATGGACTTTTATTTTCTCTCTGTTTGGTGCTCTAAGTGGGTTTGTAGCCACTTTT
 401 CTGTTACTTTATGATTCTCATTTCAACAGGAATGGCCAGTAAAAGTTGTTTTATTTTTCCTGTTAAGGTTTATAACCTTT
 481 TTACATTTTTGACCTGTATTAGATTAGAATTTCATTATGCATTCCTTTTAGTTGAGGCGCTTCATAGTTTTCTGGAGATA
 561 GTCAATTTTTAGTTTTTTATTATACATTTGAATGGCCGTTTTCCTGCTTTGTCTGCCTGCACATTGTATATTTGTTTAAA
 641 AATATTCTCTACTTTTAGTCTATGTAAGTTTCATTTAGAAAGACATGCATTTATATTTTGTTTCTGTAATATTCTACTGT
 721 AGGTGAAATCTTTTCAAAAATCAAGAGACTGGGTAGATAAGAATATATGAATGACTAATATACAAAAGATTTAAACCATT
 801 GTGATGGCGTATATTCTCAAATGGTAATATCTTGCAATGGCACACAGATTTAATGGATAAAGGTATACCTCAGACTTCAC
 881 TGTGCTCACAAATCTTTGAGGAGAAAGTTTGGTCACCTGTTTGGCTTGATTTAGTTACTGCTGCCTTTGGTTTTCTCCAG
 961 GAATGAAGTATTCAGCACAGTGACTCAGTATTTTTAGTTATTTTGCATGGGCTGGTAGTACCTCTGTTATGCTCTCAGTT
1041 ACAATCAATTTAAAACTGTATAACAGTCTTGGTACCTAACAGTAGCTATGCATAATCCTGTGGCACAGTACACTCCCAAG
1121 CCACCAATGCAGTTAATATGCTCTCATAGTGGTTTTTCTATGCTATATGAAAATAGTCTTCAAGCCTTGGTTCTCTAATG
1201 CAGCTACCACAAGAGGTTGATATTTTTATAGTGGCGTGTAATCTCCTTTTCGGGAGGCTTTTTATGGAAGGTAGAATTTG
1281 TAAAAGTTCGTATGCTTTGCCTCTCAACTGCATTAACATGCCACAGGCTCAGACTGTTTTTGTGTAAAGGATGTCAAAGA
1361 ACGGCACTTTTTCTAAAGAGAAGTTTGATATTTTGTATGCTTGTTAAGAAAGTACAGTATTGGAAATTAAAGGTGGACAA
1441 CTGATAATTGAGGAGTATGTCAATTAATTTTTTATGTATATTACCTGTTTACTTGTACAACTTACTGTACAAATTACATG
1521 CAGCTTCATTTTCAAATGAATCCTTAAAATAAGGAAATCTTTTTAGGAAAACATTTAATTTTTGTATTTTTGATTTTAAA
1601 GGCATGAGTTATGTCAATTTTCAGTGTATTAATGAAGATTTTAACTTTTCATCAGGTTGAGTGTTTTCTTACTATATTAT
1681 CTGTTGTGTATGTAGTTAGCATATTGTGTCACTGAACTGTTTAAAAATCTAGCATGTAGAGCAAGCCTGTTTTGTGGAAA
1761 ATCCTTATTCATTAAAAAAATAATCATGGCAGATTTTCTGCAAAAAAAAAACAAAAGCATTTGCAATTCAGAATACTGAT
1841 TTTTTTAATTTTATTTAAAGAAAGGTATTTTGCTTGCAGGAAAAAAATACTACAGATTCATTTTAATGAGAATCTTTGAA
1921 ATGTATTTATCTTTAGGGCATCTGGGCATCTTTATGCTGTTTGTCTTCTGTCTTTCTTGAAATAAAATGTACATACGTTA
2001 CCTTTACATATGCTCTTGCTCAAAATTGTGAACCTAGTTACATTTCTCCCTGCTCCCTTCCTTTTTATGCTCAAACAGCG
2081 AAACCCAAAACTTAAAAGATCTGAACTTTCAGCATGCATTCTGATTGCTGAAAGATTTCCTGATTTAGTGCATTCTCAAA
2161 AGGGCTTTCCCATAATCTAAAGGGAAATGTAAGCACCTATACTCTTGTGCCTGTGGGCACTTCAATAATAAAAACCAACT
2241 TTTTAAACTAATCATCTTTTATCAATGATAAAGTTGTTTTCAGTCCCACACTAGGAGAGTTCCTTTAAGTCAGCTGATCA
2321 AGCATAAGATACTTCCGTAAAGAAATAAACTAAGAAAATTTTTTATGGCTTGAGAAAATTCCTTGAGGCCAAATTAATAT
2401 ATTTTTCTTTGTTATTTTATTTGAGTCATTTTAAATTTGTTAATACAAAATTTAAGATAATTTACAGAGACAATTTATCC
2481 AGCTTCCTTCTACCTTAATACAATGTTTTGTCTTCCCATTATCCTCTCTTTTCTTTATCTGTTGGTAGATGTAAAAAACT
2561 TCCATTTAGTTAATCGGAGGTGTGTATTTTTTAAATTGAAATGTGCCCAGCCCCTTCAGCTCACACAGGAAACATGAACT
2641 CTTAAAAAACTGACTAGTAAATGCAGGAGAGGTGGATACCTGATGAGACACAGCGAAAGTGACCTGTATACACATTACAA
2721 CTCTGGAGTACATATTAAAGTCGTGCTATTTCCAGTGGTAAATGTCTGACTTTTAAGACATTCTTTTAAATATTTGTATC
2801 ATTGTTAGGATGTTTTAATCAGTTGTTTTTTAATTCCATGTAATATATGTAGCCCTCATCAGATTTATATCACCATATTT
2881 CTCCTTGTGTCCTAAGAGAATTGATGACAATTCGTAACCATAAATTGTTTTATATTAGCTAGTATGTATATTTATTTTTA
2961 CCCAATGGCTTTATCTGTTTCCCAAAATTTGTTTGGGATTTGTTGAAAGCATTGTGTAACTTCTATAAACGGCTATTTTC
3041 TTGTAACTGTCAGTGAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucGGUGUUAGUGGAAGACUAGa 5'
            :||  || :| |||||||: 
Target 5' ttTCAGCAT-GCATTCTGATTg 3'
 2107 - 2127 139.00 -8.00
2 
miRNA  3' ucGGUGUUAGUGGAAGACUAGa 5'
            ||::  |  ::|||| ||| 
Target 5' ccCCGTCTTGCTTTTCTTATCt 3'
 102 - 123 120.00 -8.40
3 
miRNA  3' ucgguguuaguggaaGACUAGa 5'
                         |||||| 
Target 5' gttcctttaagtcagCTGATCa 3'
 2299 - 2320 120.00 -11.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30481394 33 COSMIC
COSN30481424 34 COSMIC
COSN30513607 48 COSMIC
COSN32052615 54 COSMIC
COSN31607302 67 COSMIC
COSN30147912 87 COSMIC
COSN30513459 127 COSMIC
COSN30545306 137 COSMIC
COSN31548472 257 COSMIC
COSN31566859 648 COSMIC
COSN31607125 791 COSMIC
COSN26177931 887 COSMIC
COSN31566876 1021 COSMIC
COSN31585571 1182 COSMIC
COSN24305322 1205 COSMIC
COSN26557130 1217 COSMIC
COSN31520310 1290 COSMIC
COSN24305189 1448 COSMIC
COSN30174112 1534 COSMIC
COSN31610813 1633 COSMIC
COSN31529969 1725 COSMIC
COSN31528332 1805 COSMIC
COSN27517388 1812 COSMIC
COSN31578980 1864 COSMIC
COSN31522870 1866 COSMIC
COSN7045624 1998 COSMIC
COSN5397450 2354 COSMIC
COSN1676503 2701 COSMIC
COSN28646075 2767 COSMIC
COSN30362563 2801 COSMIC
COSN31590221 2810 COSMIC
COSN17777957 2960 COSMIC
COSN28766955 3142 COSMIC
COSN1676504 3414 COSMIC
COSN27732996 4176 COSMIC
COSN39700 4176 COSMIC
COSN16702052 4314 COSMIC
COSN27412242 4348 COSMIC
COSN29013274 4348 COSMIC
COSN26743553 4441 COSMIC
COSN1676505 4675 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs966661526 2 dbSNP
rs1045586806 7 dbSNP
rs770956735 11 dbSNP
rs774482979 14 dbSNP
rs978448818 20 dbSNP
rs376234715 24 dbSNP
rs1032219420 29 dbSNP
rs958053659 30 dbSNP
rs1186880094 31 dbSNP
rs990767588 31 dbSNP
rs760585776 32 dbSNP
rs1469106211 34 dbSNP
rs375935238 38 dbSNP
rs1251322418 39 dbSNP
rs1251354737 44 dbSNP
rs753607822 46 dbSNP
rs761548807 47 dbSNP
rs1251267426 51 dbSNP
rs1205351259 56 dbSNP
rs1234625627 57 dbSNP
rs1309638204 62 dbSNP
rs1034526821 70 dbSNP
rs1233990968 71 dbSNP
rs1176877251 72 dbSNP
rs1369839698 79 dbSNP
rs1300752008 90 dbSNP
rs957036935 100 dbSNP
rs761248094 103 dbSNP
rs1297539981 104 dbSNP
rs1011639776 105 dbSNP
rs867829580 106 dbSNP
rs548964955 107 dbSNP
rs547159866 109 dbSNP
rs564196544 112 dbSNP
rs1433837610 126 dbSNP
rs967596688 135 dbSNP
rs1195683195 144 dbSNP
rs1037996506 146 dbSNP
rs1191452480 163 dbSNP
rs1481941092 164 dbSNP
rs766840755 165 dbSNP
rs976344843 168 dbSNP
rs1468049701 169 dbSNP
rs532750370 179 dbSNP
rs762134529 180 dbSNP
rs1331320048 186 dbSNP
rs1008358465 189 dbSNP
rs1375500129 200 dbSNP
rs1308523632 201 dbSNP
rs1433895389 211 dbSNP
rs1410423057 212 dbSNP
rs1373331204 223 dbSNP
rs1175765967 224 dbSNP
rs1019352818 235 dbSNP
rs138502736 236 dbSNP
rs1420915612 250 dbSNP
rs1253196636 255 dbSNP
rs1187784987 259 dbSNP
rs569530662 265 dbSNP
rs1352304389 270 dbSNP
rs532046194 271 dbSNP
rs1326239356 281 dbSNP
rs1372648969 293 dbSNP
rs1443577002 298 dbSNP
rs999297605 306 dbSNP
rs942152648 309 dbSNP
rs1259752361 311 dbSNP
rs1036760886 315 dbSNP
rs919296261 317 dbSNP
rs1301657169 319 dbSNP
rs1318152578 346 dbSNP
rs1032248820 352 dbSNP
rs1414020458 352 dbSNP
rs1367550152 355 dbSNP
rs957919117 366 dbSNP
rs1314557130 382 dbSNP
rs1396371905 393 dbSNP
rs1275681791 395 dbSNP
rs1384562216 404 dbSNP
rs929837888 409 dbSNP
rs1455422885 416 dbSNP
rs1412712813 420 dbSNP
rs1024017468 430 dbSNP
rs567285461 431 dbSNP
rs1045684203 454 dbSNP
rs765450904 459 dbSNP
rs1001792102 461 dbSNP
rs1198069036 469 dbSNP
rs1215852446 473 dbSNP
rs774648346 483 dbSNP
rs531875920 494 dbSNP
rs1260639209 495 dbSNP
rs892864022 506 dbSNP
rs962553987 514 dbSNP
rs1268287508 515 dbSNP
rs1232139482 519 dbSNP
rs750646374 521 dbSNP
rs1295007914 522 dbSNP
rs1245272230 532 dbSNP
rs1325577037 534 dbSNP
rs1252090578 539 dbSNP
rs548537040 540 dbSNP
rs1188280055 547 dbSNP
rs1384199010 557 dbSNP
rs867151186 565 dbSNP
rs1417282639 566 dbSNP
rs967021563 566 dbSNP
rs1325361476 567 dbSNP
rs1427423203 569 dbSNP
rs932185326 572 dbSNP
rs1164296405 573 dbSNP
rs1475302047 573 dbSNP
rs1371636233 583 dbSNP
rs1195776020 589 dbSNP
rs1049431770 591 dbSNP
rs1248238639 598 dbSNP
rs568380738 598 dbSNP
rs910913784 599 dbSNP
rs1459505912 605 dbSNP
rs997689389 607 dbSNP
rs1349702221 608 dbSNP
rs758440568 612 dbSNP
rs371036902 614 dbSNP
rs1041217854 618 dbSNP
rs1229306107 629 dbSNP
rs1366247095 638 dbSNP
rs1302899820 639 dbSNP
rs1186585575 645 dbSNP
rs1431922321 650 dbSNP
rs534234230 653 dbSNP
rs902246624 663 dbSNP
rs1030554787 664 dbSNP
rs999327064 666 dbSNP
rs953551169 669 dbSNP
rs143093656 673 dbSNP
rs780124203 688 dbSNP
rs1293942797 693 dbSNP
rs1337250817 698 dbSNP
rs1212107286 704 dbSNP
rs1170057580 710 dbSNP
rs1430771880 710 dbSNP
rs1289427979 713 dbSNP
rs1390427171 733 dbSNP
rs373146098 734 dbSNP
rs1016463486 743 dbSNP
rs1452037356 751 dbSNP
rs770274457 753 dbSNP
rs570651348 759 dbSNP
rs1198933103 760 dbSNP
rs751702932 765 dbSNP
rs1240289917 770 dbSNP
rs1270757675 774 dbSNP
rs1487901301 775 dbSNP
rs1188077646 776 dbSNP
rs972143985 778 dbSNP
rs1232286005 789 dbSNP
rs1370000833 792 dbSNP
rs1275576176 796 dbSNP
rs756010984 799 dbSNP
rs1012083865 800 dbSNP
rs1334556053 801 dbSNP
rs1473923215 808 dbSNP
rs1331416340 809 dbSNP
rs919223044 810 dbSNP
rs949375511 816 dbSNP
rs981331888 819 dbSNP
rs1375148655 832 dbSNP
rs928524450 836 dbSNP
rs1432542004 837 dbSNP
rs531595295 838 dbSNP
rs1469144714 841 dbSNP
rs1231125127 854 dbSNP
rs1320611951 855 dbSNP
rs937301677 860 dbSNP
rs1343979199 862 dbSNP
rs1056025531 864 dbSNP
rs893010113 869 dbSNP
rs1208451949 870 dbSNP
rs1314215561 875 dbSNP
rs1399880273 892 dbSNP
rs1223324376 899 dbSNP
rs1313996355 901 dbSNP
rs35238987 902 dbSNP
rs1348555536 911 dbSNP
rs947086692 917 dbSNP
rs1290759317 938 dbSNP
rs539204057 939 dbSNP
rs1229619360 941 dbSNP
rs1003526110 951 dbSNP
rs187591825 958 dbSNP
rs1311490390 960 dbSNP
rs1357490548 961 dbSNP
rs113514222 971 dbSNP
rs767685875 979 dbSNP
rs973573339 992 dbSNP
rs920730428 996 dbSNP
rs1283836537 1005 dbSNP
rs997159508 1006 dbSNP
rs953518262 1019 dbSNP
rs541774729 1022 dbSNP
rs1160742416 1027 dbSNP
rs1351590699 1031 dbSNP
rs1185582072 1033 dbSNP
rs191520294 1059 dbSNP
rs181662692 1061 dbSNP
rs1238292483 1081 dbSNP
rs1215247042 1082 dbSNP
rs1445489800 1093 dbSNP
rs1270157837 1100 dbSNP
rs1229059982 1102 dbSNP
rs1334805406 1108 dbSNP
rs1291929212 1114 dbSNP
rs1029980082 1116 dbSNP
rs1281827999 1117 dbSNP
rs1380272145 1121 dbSNP
rs1284431441 1143 dbSNP
rs78815918 1144 dbSNP
rs1322033788 1148 dbSNP
rs186854637 1149 dbSNP
rs1177724897 1151 dbSNP
rs1259521260 1156 dbSNP
rs1016804241 1161 dbSNP
rs963585530 1165 dbSNP
rs75554011 1166 dbSNP
rs1233100845 1168 dbSNP
rs1026417080 1170 dbSNP
rs970824669 1182 dbSNP
rs1474577920 1186 dbSNP
rs546372617 1190 dbSNP
rs1160676951 1209 dbSNP
rs1406300273 1210 dbSNP
rs1271838975 1211 dbSNP
rs375977215 1214 dbSNP
rs1322851326 1215 dbSNP
rs1272823634 1217 dbSNP
rs749666290 1218 dbSNP
rs1012030202 1227 dbSNP
rs926677495 1231 dbSNP
rs1435217307 1232 dbSNP
rs906422662 1236 dbSNP
rs563099199 1237 dbSNP
rs991425707 1246 dbSNP
rs914356379 1247 dbSNP
rs1396100178 1252 dbSNP
rs1350375426 1253 dbSNP
rs1169532959 1260 dbSNP
rs769162889 1262 dbSNP
rs1333545183 1267 dbSNP
rs1336606589 1273 dbSNP
rs1392277117 1283 dbSNP
rs1189386627 1284 dbSNP
rs756217353 1288 dbSNP
rs377108970 1290 dbSNP
rs1014890031 1291 dbSNP
rs947236367 1293 dbSNP
rs1041425772 1301 dbSNP
rs1489123958 1304 dbSNP
rs1232782704 1329 dbSNP
rs897922365 1330 dbSNP
rs1352802307 1337 dbSNP
rs902924422 1343 dbSNP
rs933101583 1348 dbSNP
rs1051861298 1350 dbSNP
rs1228768548 1356 dbSNP
rs189946021 1363 dbSNP
rs538842948 1364 dbSNP
rs778559842 1376 dbSNP
rs1282398064 1384 dbSNP
rs1368248134 1390 dbSNP
rs1297485153 1391 dbSNP
rs1407776611 1412 dbSNP
rs1008188435 1418 dbSNP
rs1019627102 1420 dbSNP
rs1037969075 1433 dbSNP
rs1434401886 1449 dbSNP
rs771841292 1450 dbSNP
rs976826873 1459 dbSNP
rs1439020807 1460 dbSNP
rs780317481 1462 dbSNP
rs899304258 1464 dbSNP
rs1439487291 1468 dbSNP
rs1194586717 1475 dbSNP
rs1253057767 1486 dbSNP
rs934987574 1488 dbSNP
rs1485163213 1496 dbSNP
rs989227347 1508 dbSNP
rs111697490 1513 dbSNP
rs1234806464 1515 dbSNP
rs1312200632 1533 dbSNP
rs1306205579 1536 dbSNP
rs1226568464 1544 dbSNP
rs1352243744 1547 dbSNP
rs1397462345 1550 dbSNP
rs1464941517 1560 dbSNP
rs548587442 1563 dbSNP
rs370478376 1572 dbSNP
rs1413912156 1573 dbSNP
rs1397355719 1578 dbSNP
rs1411729548 1579 dbSNP
rs568765155 1585 dbSNP
rs527673597 1593 dbSNP
rs947917676 1605 dbSNP
rs1157031105 1606 dbSNP
rs1473884610 1613 dbSNP
rs1413298031 1616 dbSNP
rs1376358488 1618 dbSNP
rs1044883633 1619 dbSNP
rs1441367541 1627 dbSNP
rs906447460 1637 dbSNP
rs1201751122 1647 dbSNP
rs1305302462 1658 dbSNP
rs1483369546 1661 dbSNP
rs1206260321 1664 dbSNP
rs1259693685 1664 dbSNP
rs1026512086 1675 dbSNP
rs1232504941 1692 dbSNP
rs1288866334 1706 dbSNP
rs1036683010 1723 dbSNP
rs1338426792 1724 dbSNP
rs1315119041 1737 dbSNP
rs970793552 1753 dbSNP
rs547395313 1757 dbSNP
rs1157444211 1758 dbSNP
rs1384495667 1763 dbSNP
rs768861596 1767 dbSNP
rs1003668138 1769 dbSNP
rs1034058642 1772 dbSNP
rs1370627393 1774 dbSNP
rs889177129 1774 dbSNP
rs554373257 1775 dbSNP
rs970442929 1778 dbSNP
rs1424081948 1779 dbSNP
rs1257037776 1781 dbSNP
rs1468610744 1787 dbSNP
rs1186160317 1793 dbSNP
rs1214731676 1794 dbSNP
rs1255342255 1799 dbSNP
rs1008158744 1802 dbSNP
rs1209102388 1802 dbSNP
rs201721922 1802 dbSNP
rs760542395 1802 dbSNP
rs570561610 1804 dbSNP
rs566399349 1809 dbSNP
rs1374131459 1810 dbSNP
rs1365935505 1811 dbSNP
rs1325295347 1812 dbSNP
rs1393489620 1813 dbSNP
rs1404154325 1813 dbSNP
rs977736520 1815 dbSNP
rs1461762981 1817 dbSNP
rs1389192384 1819 dbSNP
rs914514256 1830 dbSNP
rs968632133 1835 dbSNP
rs1031879594 1837 dbSNP
rs977213527 1839 dbSNP
rs1449831109 1840 dbSNP
rs775467277 1844 dbSNP
rs182675506 1847 dbSNP
rs1399873451 1848 dbSNP
rs1462115588 1849 dbSNP
rs1328145031 1854 dbSNP
rs915011329 1857 dbSNP
rs1386003193 1877 dbSNP
rs1341120287 1879 dbSNP
rs565127179 1881 dbSNP
rs536900022 1893 dbSNP
rs1365521149 1894 dbSNP
rs981021473 1896 dbSNP
rs927853437 1897 dbSNP
rs1434360200 1905 dbSNP
rs1276967235 1906 dbSNP
rs555905511 1907 dbSNP
rs1234795489 1915 dbSNP
rs1051528659 1921 dbSNP
rs1270882268 1926 dbSNP
rs1487744571 1931 dbSNP
rs939181760 1932 dbSNP
rs910179479 1938 dbSNP
rs943066849 1941 dbSNP
rs1369032412 1953 dbSNP
rs1037795220 1954 dbSNP
rs899401602 1955 dbSNP
rs993783172 1959 dbSNP
rs1390383062 1963 dbSNP
rs1263048100 1970 dbSNP
rs1047922005 1971 dbSNP
rs753806307 1971 dbSNP
rs897734622 1975 dbSNP
rs906701519 1993 dbSNP
rs1191620795 1994 dbSNP
rs186638174 1997 dbSNP
rs1033782101 1998 dbSNP
rs1475558279 2014 dbSNP
rs1207005421 2015 dbSNP
rs959612790 2019 dbSNP
rs1483528728 2020 dbSNP
rs1278137020 2023 dbSNP
rs1167454439 2026 dbSNP
rs1347144659 2036 dbSNP
rs1010889501 2038 dbSNP
rs889205051 2049 dbSNP
rs1007606029 2051 dbSNP
rs1310295820 2053 dbSNP
rs1040849000 2054 dbSNP
rs902048906 2055 dbSNP
rs771906588 2056 dbSNP
rs1289192219 2064 dbSNP
rs1387077879 2066 dbSNP
rs1403806814 2068 dbSNP
rs999410665 2068 dbSNP
rs1022748080 2071 dbSNP
rs189819256 2075 dbSNP
rs1184120145 2081 dbSNP
rs977350903 2092 dbSNP
rs1010532012 2104 dbSNP
rs1237132365 2104 dbSNP
rs1297475378 2111 dbSNP
rs1355620242 2113 dbSNP
rs1234582136 2114 dbSNP
rs183802169 2115 dbSNP
rs1208165151 2116 dbSNP
rs1021882982 2120 dbSNP
rs924411024 2121 dbSNP
rs1327754518 2125 dbSNP
rs1291076193 2127 dbSNP
rs954555445 2133 dbSNP
rs987600381 2146 dbSNP
rs969453097 2150 dbSNP
rs1378809886 2152 dbSNP
rs1282784300 2159 dbSNP
rs910281964 2163 dbSNP
rs188910145 2170 dbSNP
rs1445433362 2178 dbSNP
rs572346858 2179 dbSNP
rs1244550631 2192 dbSNP
rs1334288030 2196 dbSNP
rs554645560 2198 dbSNP
rs943140902 2203 dbSNP
rs1037362267 2205 dbSNP
rs1304406158 2211 dbSNP
rs920298155 2214 dbSNP
rs1179892483 2221 dbSNP
rs971864181 2226 dbSNP
rs775137594 2227 dbSNP
rs374127962 2231 dbSNP
rs1048016448 2239 dbSNP
rs1463551877 2241 dbSNP
rs1423414785 2243 dbSNP
rs540630380 2252 dbSNP
rs557789844 2253 dbSNP
rs1160077424 2255 dbSNP
rs930506874 2260 dbSNP
rs193118876 2264 dbSNP
rs1209971889 2266 dbSNP
rs575943548 2271 dbSNP
rs1321627538 2283 dbSNP
rs1288230386 2286 dbSNP
rs1230353347 2288 dbSNP
rs1365364966 2295 dbSNP
rs1049097698 2300 dbSNP
rs910585659 2303 dbSNP
rs1315253488 2311 dbSNP
rs1433732616 2323 dbSNP
rs767787083 2323 dbSNP
rs1321968359 2325 dbSNP
rs906671859 2330 dbSNP
rs939555151 2337 dbSNP
rs1055726036 2338 dbSNP
rs1349211399 2340 dbSNP
rs901911530 2343 dbSNP
rs760303248 2349 dbSNP
rs1414812276 2352 dbSNP
rs1375933175 2359 dbSNP
rs1168121488 2366 dbSNP
rs1053178292 2367 dbSNP
rs74009191 2373 dbSNP
rs1189271730 2375 dbSNP
rs1378015877 2375 dbSNP
rs895220396 2379 dbSNP
rs1245444757 2385 dbSNP
rs1011818872 2389 dbSNP
rs1322640067 2393 dbSNP
rs543560447 2396 dbSNP
rs1011443833 2398 dbSNP
rs1238414050 2406 dbSNP
rs1339623613 2408 dbSNP
rs1285944192 2416 dbSNP
rs969107797 2423 dbSNP
rs769265068 2426 dbSNP
rs1002266408 2436 dbSNP
rs1213142195 2437 dbSNP
rs902527185 2440 dbSNP
rs1307161319 2450 dbSNP
rs1254392221 2451 dbSNP
rs866259068 2454 dbSNP
rs1428116231 2464 dbSNP
rs1392223058 2466 dbSNP
rs1171260754 2471 dbSNP
rs369349136 2472 dbSNP
rs1423703466 2504 dbSNP
rs1178065983 2508 dbSNP
rs777027515 2513 dbSNP
rs1489091274 2518 dbSNP
rs537176971 2529 dbSNP
rs1252915684 2541 dbSNP
rs558353103 2553 dbSNP
rs1276289088 2561 dbSNP
rs1227553138 2570 dbSNP
rs563409264 2572 dbSNP
rs536237496 2576 dbSNP
rs998697890 2577 dbSNP
rs1031565567 2578 dbSNP
rs1346041928 2581 dbSNP
rs183465934 2599 dbSNP
rs1407720720 2603 dbSNP
rs762202842 2608 dbSNP
rs35228740 2611 dbSNP
rs1372665188 2625 dbSNP
rs1436449186 2628 dbSNP
rs773222414 2635 dbSNP
rs971892136 2639 dbSNP
rs760804329 2651 dbSNP
rs1173838668 2666 dbSNP
rs1017888252 2672 dbSNP
rs964490224 2675 dbSNP
rs919057660 2679 dbSNP
rs973564629 2680 dbSNP
rs920224905 2681 dbSNP
rs1299584741 2690 dbSNP
rs951849101 2690 dbSNP
rs1253526276 2692 dbSNP
rs576836197 2695 dbSNP
rs928970250 2696 dbSNP
rs150721496 2706 dbSNP
rs984742183 2708 dbSNP
rs1445030844 2721 dbSNP
rs34116058 2725 dbSNP
rs562202066 2726 dbSNP
rs1267371586 2730 dbSNP
rs1226358138 2733 dbSNP
rs1352030419 2741 dbSNP
rs187552746 2743 dbSNP
rs1395726694 2744 dbSNP
rs1372154271 2745 dbSNP
rs943412049 2757 dbSNP
rs1304705091 2764 dbSNP
rs2288340 2767 dbSNP
rs1388583944 2775 dbSNP
rs191758818 2784 dbSNP
rs533189451 2793 dbSNP
rs1205238368 2799 dbSNP
rs1422918489 2801 dbSNP
rs1055292423 2803 dbSNP
rs1253305896 2804 dbSNP
rs934712821 2806 dbSNP
rs1267433599 2812 dbSNP
rs1206819709 2814 dbSNP
rs71799705 2822 dbSNP
rs1261144902 2843 dbSNP
rs773429632 2852 dbSNP
rs1197797872 2858 dbSNP
rs1243760982 2859 dbSNP
rs893345956 2865 dbSNP
rs1455393980 2867 dbSNP
rs947540086 2868 dbSNP
rs184343356 2876 dbSNP
rs1318602386 2882 dbSNP
rs946785208 2886 dbSNP
rs1386270884 2887 dbSNP
rs1001897466 2904 dbSNP
rs766625704 2906 dbSNP
rs902496297 2914 dbSNP
rs751613068 2925 dbSNP
rs1444861738 2927 dbSNP
rs999462578 2928 dbSNP
rs1171822975 2932 dbSNP
rs1448706032 2935 dbSNP
rs1397703247 2946 dbSNP
rs1029645991 2949 dbSNP
rs890369414 2950 dbSNP
rs570178665 2951 dbSNP
rs535283339 2966 dbSNP
rs1247060557 2968 dbSNP
rs1341691803 2969 dbSNP
rs1026064808 2976 dbSNP
rs1230646035 2984 dbSNP
rs549172050 2985 dbSNP
rs951880207 2988 dbSNP
rs755068553 2994 dbSNP
rs964909314 2995 dbSNP
rs1292306704 2996 dbSNP
rs866551740 3006 dbSNP
rs1367441120 3015 dbSNP
rs1304117975 3017 dbSNP
rs1215278222 3026 dbSNP
rs1280115597 3031 dbSNP
rs973148429 3032 dbSNP
rs1218293071 3033 dbSNP
rs1027424375 3036 dbSNP
rs1476082539 3036 dbSNP
rs544358906 3043 dbSNP
rs1449776999 3044 dbSNP
rs1270837847 3048 dbSNP
rs1453169561 3049 dbSNP
rs1219037065 3053 dbSNP
rs1222908314 3067 dbSNP
rs1482868179 3071 dbSNP
rs964961898 3080 dbSNP
rs201492358 3093 dbSNP
rs868207401 3093 dbSNP
rs1340076492 3094 dbSNP
rs923300780 3096 dbSNP
rs1246059478 3098 dbSNP
rs1333313545 3100 dbSNP
rs1284375606 3104 dbSNP
rs201272769 3104 dbSNP
rs866712478 3105 dbSNP
rs763975194 3113 dbSNP
rs983103237 3118 dbSNP
rs1171456120 3119 dbSNP
rs914648099 3119 dbSNP
rs927650097 3126 dbSNP
rs565789798 3127 dbSNP
rs1044936861 3132 dbSNP
rs1249892597 3132 dbSNP
rs79771655 3133 dbSNP
rs991483685 3136 dbSNP
rs1278064912 3137 dbSNP
rs534939470 3141 dbSNP
rs2259359 3142 dbSNP
rs1043893378 3143 dbSNP
rs1228181903 3151 dbSNP
rs1348950232 3154 dbSNP
rs1281638584 3159 dbSNP
rs896190986 3161 dbSNP
rs993143064 3164 dbSNP
rs1026097297 3168 dbSNP
rs924013907 3171 dbSNP
rs577699304 3175 dbSNP
rs1408226818 3177 dbSNP
rs188207788 3178 dbSNP
rs1456635306 3180 dbSNP
rs1409555238 3188 dbSNP
rs1178704298 3189 dbSNP
rs192786867 3194 dbSNP
rs184415382 3201 dbSNP
rs745739888 3206 dbSNP
rs2288341 3210 dbSNP
rs113482308 3211 dbSNP
rs891122608 3219 dbSNP
rs964569639 3226 dbSNP
rs1208726610 3231 dbSNP
rs542009788 3235 dbSNP
rs1039376852 3236 dbSNP
rs1350968615 3240 dbSNP
rs900310107 3245 dbSNP
rs1283177213 3246 dbSNP
rs1399462571 3247 dbSNP
rs1384445678 3250 dbSNP
rs779902686 3255 dbSNP
rs1434344877 3259 dbSNP
rs746469088 3261 dbSNP
rs1358654960 3268 dbSNP
rs988746802 3293 dbSNP
rs562325980 3294 dbSNP
rs112495294 3296 dbSNP
rs1413366512 3300 dbSNP
rs1161616122 3304 dbSNP
rs541310705 3307 dbSNP
rs574397843 3308 dbSNP
rs777133085 3314 dbSNP
rs760268930 3315 dbSNP
rs748620549 3321 dbSNP
rs1317259971 3323 dbSNP
rs1218791117 3328 dbSNP
rs564468305 3332 dbSNP
rs1463957142 3335 dbSNP
rs980305023 3336 dbSNP
rs960662566 3341 dbSNP
rs1451325765 3345 dbSNP
rs533151261 3350 dbSNP
rs991061014 3356 dbSNP
rs549802844 3367 dbSNP
rs1315190008 3369 dbSNP
rs938859388 3383 dbSNP
rs968355782 3384 dbSNP
rs979559700 3385 dbSNP
rs1192617954 3389 dbSNP
rs868856181 3390 dbSNP
rs1162254732 3402 dbSNP
rs918827496 3403 dbSNP
rs928968666 3406 dbSNP
rs1047404518 3408 dbSNP
rs563592593 3411 dbSNP
rs924149754 3412 dbSNP
rs1386045366 3418 dbSNP
rs879572566 3420 dbSNP
rs1006349350 3423 dbSNP
rs1447669154 3424 dbSNP
rs541714313 3426 dbSNP
rs1359121532 3431 dbSNP
rs558687841 3435 dbSNP
rs1477979988 3442 dbSNP
rs900356830 3447 dbSNP
rs1419175899 3453 dbSNP
rs997347225 3455 dbSNP
rs1313515276 3461 dbSNP
rs1030221122 3467 dbSNP
rs1291990133 3481 dbSNP
rs560997060 3481 dbSNP
rs1283814662 3484 dbSNP
rs912536139 3487 dbSNP
rs1373860674 3488 dbSNP
rs1021549363 3493 dbSNP
rs942714386 3495 dbSNP
rs1241978157 3496 dbSNP
rs1215153052 3503 dbSNP
rs1283807345 3507 dbSNP
rs575426666 3513 dbSNP
rs1177167231 3516 dbSNP
rs1366797975 3520 dbSNP
rs1352847675 3532 dbSNP
rs1281173322 3536 dbSNP
rs1039731644 3537 dbSNP
rs529393030 3542 dbSNP
rs994790771 3543 dbSNP
rs1048924052 3554 dbSNP
rs1211012288 3565 dbSNP
rs1280193914 3574 dbSNP
rs980631895 3578 dbSNP
rs1460652805 3599 dbSNP
rs886277778 3600 dbSNP
rs1171197341 3621 dbSNP
rs960511194 3622 dbSNP
rs1427766724 3623 dbSNP
rs1004603323 3626 dbSNP
rs918860404 3628 dbSNP
rs1269162966 3633 dbSNP
rs1181098743 3645 dbSNP
rs879029644 3649 dbSNP
rs773415077 3650 dbSNP
rs372341569 3651 dbSNP
rs930171528 3654 dbSNP
rs1047435547 3656 dbSNP
rs908918283 3659 dbSNP
rs1225116879 3660 dbSNP
rs78924379 3663 dbSNP
rs960508839 3668 dbSNP
rs941687814 3675 dbSNP
rs1039224063 3680 dbSNP
rs1298851247 3681 dbSNP
rs1465565815 3681 dbSNP
rs1404554685 3682 dbSNP
rs12440655 3683 dbSNP
rs997779621 3691 dbSNP
rs1404523616 3693 dbSNP
rs1051510473 3698 dbSNP
rs1157350869 3698 dbSNP
rs534851787 3707 dbSNP
rs1416984659 3716 dbSNP
rs551683051 3722 dbSNP
rs1177285112 3730 dbSNP
rs1482604441 3734 dbSNP
rs531587648 3737 dbSNP
rs1205546019 3739 dbSNP
rs891723488 3748 dbSNP
rs1355270337 3754 dbSNP
rs190525039 3755 dbSNP
rs537036961 3762 dbSNP
rs1307891449 3763 dbSNP
rs1375853405 3767 dbSNP
rs1395538640 3775 dbSNP
rs556917844 3776 dbSNP
rs778875628 3783 dbSNP
rs1380747090 3814 dbSNP
rs573624659 3819 dbSNP
rs1454017832 3829 dbSNP
rs1388515357 3832 dbSNP
rs1287505081 3840 dbSNP
rs1234974983 3844 dbSNP
rs182138659 3850 dbSNP
rs956881078 3867 dbSNP
rs1365200484 3871 dbSNP
rs969144883 3873 dbSNP
rs1001527766 3874 dbSNP
rs1342331027 3882 dbSNP
rs986879970 3884 dbSNP
rs1034858519 3885 dbSNP
rs1184883323 3897 dbSNP
rs1461729475 3900 dbSNP
rs960127220 3904 dbSNP
rs552827104 3912 dbSNP
rs1486690296 3917 dbSNP
rs185830687 3926 dbSNP
rs1382496036 3931 dbSNP
rs918723025 3935 dbSNP
rs1200938787 3936 dbSNP
rs763354621 3938 dbSNP
rs942828163 3940 dbSNP
rs779379404 3945 dbSNP
rs975812645 3957 dbSNP
rs1317308535 3958 dbSNP
rs749841532 3958 dbSNP
rs1246736198 3961 dbSNP
rs541273483 3965 dbSNP
rs919978938 3966 dbSNP
rs1293990404 3970 dbSNP
rs951517269 3971 dbSNP
rs984396102 3972 dbSNP
rs766535862 3974 dbSNP
rs910123273 3980 dbSNP
rs1439467472 3981 dbSNP
rs1200270811 3983 dbSNP
rs1049016484 3984 dbSNP
rs74405840 3992 dbSNP
rs1191004702 3993 dbSNP
rs940526850 3995 dbSNP
rs1221428049 3996 dbSNP
rs1424638045 3998 dbSNP
rs974413654 4011 dbSNP
rs1056326704 4027 dbSNP
rs1268491316 4030 dbSNP
rs1230313959 4037 dbSNP
rs577926732 4039 dbSNP
rs1012035513 4042 dbSNP
rs933052251 4043 dbSNP
rs1403451068 4045 dbSNP
rs1023681957 4047 dbSNP
rs903535860 4056 dbSNP
rs189119564 4057 dbSNP
rs146028810 4067 dbSNP
rs1165618266 4068 dbSNP
rs1231927937 4075 dbSNP
rs372056441 4078 dbSNP
rs1463504709 4079 dbSNP
rs956975478 4081 dbSNP
rs1198454834 4093 dbSNP
rs987362322 4096 dbSNP
rs1270764513 4100 dbSNP
rs1019815000 4111 dbSNP
rs964474375 4112 dbSNP
rs1437433679 4118 dbSNP
rs975527416 4128 dbSNP
rs181108100 4131 dbSNP
rs931316953 4132 dbSNP
rs1222080787 4141 dbSNP
rs1262991947 4141 dbSNP
rs1326168699 4144 dbSNP
rs543094013 4150 dbSNP
rs34029793 4159 dbSNP
rs559622901 4160 dbSNP
rs1025716772 4164 dbSNP
rs1334779616 4164 dbSNP
rs1392581532 4164 dbSNP
rs200379277 4164 dbSNP
rs951555966 4171 dbSNP
rs1431218819 4172 dbSNP
rs767506380 4172 dbSNP
rs1270137421 4173 dbSNP
rs1450344667 4176 dbSNP
rs1017623327 4177 dbSNP
rs528294528 4177 dbSNP
rs1438411294 4178 dbSNP
rs1264051237 4180 dbSNP
rs1056695878 4181 dbSNP
rs1326903850 4182 dbSNP
rs1264194957 4184 dbSNP
rs1277336664 4184 dbSNP
rs527291714 4184 dbSNP
rs185600580 4189 dbSNP
rs947759471 4190 dbSNP
rs779836684 4205 dbSNP
rs1450426334 4212 dbSNP
rs974824238 4215 dbSNP
rs562738661 4227 dbSNP
rs571518554 4235 dbSNP
rs752878352 4236 dbSNP
rs1406079750 4237 dbSNP
rs1164736745 4249 dbSNP
rs757135870 4250 dbSNP
rs376947558 4258 dbSNP
rs1181804602 4260 dbSNP
rs1463067213 4274 dbSNP
rs1000469310 4278 dbSNP
rs565251470 4286 dbSNP
rs1030653198 4288 dbSNP
rs892713111 4290 dbSNP
rs932979923 4294 dbSNP
rs1445579626 4298 dbSNP
rs987203788 4307 dbSNP
rs945894648 4312 dbSNP
rs1042845274 4314 dbSNP
rs904440898 4315 dbSNP
rs1243085543 4323 dbSNP
rs1384914689 4329 dbSNP
rs1284650997 4331 dbSNP
rs1341897619 4334 dbSNP
rs1329943569 4335 dbSNP
rs201445014 4335 dbSNP
rs1320008103 4338 dbSNP
rs1397526286 4343 dbSNP
rs1365137488 4348 dbSNP
rs1008519985 4349 dbSNP
rs1446449356 4352 dbSNP
rs1386420313 4353 dbSNP
rs1056108063 4365 dbSNP
rs1020162675 4371 dbSNP
rs1474698180 4372 dbSNP
rs964253955 4377 dbSNP
rs1216895920 4379 dbSNP
rs765261435 4380 dbSNP
rs977533561 4390 dbSNP
rs1290501522 4393 dbSNP
rs1027092551 4395 dbSNP
rs1354655268 4399 dbSNP
rs767575948 4399 dbSNP
rs1361049482 4400 dbSNP
rs1014252484 4404 dbSNP
rs190156998 4405 dbSNP
rs1359752186 4406 dbSNP
rs1271736968 4407 dbSNP
rs1400337578 4413 dbSNP
rs1345119686 4414 dbSNP
rs377372647 4422 dbSNP
rs887167938 4422 dbSNP
rs1426767604 4424 dbSNP
rs982770994 4427 dbSNP
rs1017071649 4428 dbSNP
rs1422224764 4430 dbSNP
rs1187478095 4433 dbSNP
rs908581637 4434 dbSNP
rs962229609 4442 dbSNP
rs1424564457 4444 dbSNP
rs1189851546 4445 dbSNP
rs1246833722 4453 dbSNP
rs975731713 4455 dbSNP
rs992095823 4473 dbSNP
rs1274943953 4491 dbSNP
rs954405574 4492 dbSNP
rs1322614697 4493 dbSNP
rs1281133120 4499 dbSNP
rs550269855 4502 dbSNP
rs1375195983 4505 dbSNP
rs917713047 4506 dbSNP
rs947930991 4508 dbSNP
rs1159195264 4509 dbSNP
rs368696410 4522 dbSNP
rs1417357737 4525 dbSNP
rs967060987 4526 dbSNP
rs1356805217 4527 dbSNP
rs535896100 4533 dbSNP
rs925020367 4537 dbSNP
rs925842107 4538 dbSNP
rs1179005164 4540 dbSNP
rs936458837 4542 dbSNP
rs1052049318 4547 dbSNP
rs1176125180 4548 dbSNP
rs1479337202 4553 dbSNP
rs892135811 4553 dbSNP
rs1234097771 4555 dbSNP
rs373257815 4569 dbSNP
rs377197611 4578 dbSNP
rs1244451555 4585 dbSNP
rs74512344 4591 dbSNP
rs746667359 4592 dbSNP
rs1306490865 4596 dbSNP
rs1041314866 4600 dbSNP
rs899977960 4601 dbSNP
rs139938951 4602 dbSNP
rs1404480117 4613 dbSNP
rs887200826 4619 dbSNP
rs566376848 4622 dbSNP
rs1377854920 4624 dbSNP
rs1157992267 4632 dbSNP
rs1416931290 4637 dbSNP
rs1381665372 4648 dbSNP
rs1285463557 4655 dbSNP
rs1038860110 4656 dbSNP
rs900023745 4658 dbSNP
rs1205348075 4659 dbSNP
rs557933660 4661 dbSNP
rs1483488731 4662 dbSNP
rs1259927109 4671 dbSNP
rs577889624 4675 dbSNP
rs952768099 4684 dbSNP
rs1318934324 4685 dbSNP
rs1310106290 4686 dbSNP
rs1004301100 4687 dbSNP
rs544112254 4691 dbSNP
rs1317704208 4692 dbSNP
rs960080124 4705 dbSNP
rs1397103964 4709 dbSNP
rs1384778266 4711 dbSNP
rs1287451249 4712 dbSNP
rs747762814 4719 dbSNP
rs1362023259 4722 dbSNP
rs1158733029 4729 dbSNP
rs1008518719 4736 dbSNP
rs955596647 4736 dbSNP
rs1382118796 4737 dbSNP
rs182689492 4746 dbSNP
rs1424297262 4747 dbSNP
rs917818588 4752 dbSNP
rs1184507025 4753 dbSNP
rs969724199 4759 dbSNP
rs557404802 4765 dbSNP
rs925119953 4766 dbSNP
rs978574477 4770 dbSNP
rs1294030657 4776 dbSNP
rs1246216843 4796 dbSNP
rs925675063 4808 dbSNP
rs1359297964 4815 dbSNP
rs958579026 4821 dbSNP
rs1384212361 4829 dbSNP
rs1342009205 4831 dbSNP
rs1467116153 4835 dbSNP
rs1300733174 4844 dbSNP
rs1400969747 4852 dbSNP
rs1423601468 4855 dbSNP
rs1363216346 4858 dbSNP
rs991707751 4863 dbSNP
rs1458366612 4864 dbSNP
rs1372387637 4865 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000260327.4 | 3UTR | UUUCUCAUCUUCAAAUGCCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
UCEC -0.97 0.02 -1.000 0.5 4 Click to see details
LIHC -0.323 0.05 -0.429 0.01 28 Click to see details
PAAD -0.988 0.05 -1.000 0.5 3 Click to see details
HNSC 0.417 0.1 0.191 0.29 11 Click to see details
BRCA 0.215 0.13 0.244 0.1 30 Click to see details
BLCA 0.174 0.3 0.291 0.19 11 Click to see details
CHOL -0.264 0.31 0.029 0.48 6 Click to see details
PRAD 0.074 0.32 0.125 0.21 44 Click to see details
LUSC -0.267 0.33 -0.300 0.31 5 Click to see details
STAD 0.099 0.35 0.086 0.37 18 Click to see details
STAD 0.099 0.35 0.086 0.37 18 Click to see details
STAD 0.099 0.35 0.086 0.37 18 Click to see details
STAD 0.099 0.35 0.086 0.37 18 Click to see details
STAD 0.099 0.35 0.086 0.37 18 Click to see details
STAD 0.099 0.35 0.086 0.37 18 Click to see details
STAD 0.099 0.35 0.086 0.37 18 Click to see details
STAD 0.099 0.35 0.086 0.37 18 Click to see details
96 hsa-miR-383-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT004443 VEGFA vascular endothelial growth factor A 5 2
MIRT006137 DIO1 iodothyronine deiodinase 1 3 1
MIRT006535 IRF1 interferon regulatory factor 1 3 1
MIRT007246 IGF1R insulin like growth factor 1 receptor 1 1
MIRT007305 PRDX3 peroxiredoxin 3 1 1
MIRT054359 CCND1 cyclin D1 4 2
MIRT057087 DDIT4 DNA damage inducible transcript 4 2 2
MIRT086536 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 2
MIRT086544 MOB4 MOB family member 4, phocein 2 2
MIRT438194 PPP1R10 protein phosphatase 1 regulatory subunit 10 3 1
MIRT448282 ZMYM2 zinc finger MYM-type containing 2 2 2
MIRT451601 TRPM7 transient receptor potential cation channel subfamily M member 7 2 2
MIRT453387 RHD Rh blood group D antigen 2 2
MIRT458521 C5orf22 chromosome 5 open reading frame 22 2 2
MIRT459720 SGK494 uncharacterized serine/threonine-protein kinase SgK494 2 2
MIRT461491 KIAA1009 centrosomal protein 162 1 1
MIRT463261 ZIC5 Zic family member 5 2 2
MIRT464237 VCP valosin containing protein 2 2
MIRT465320 TRAF5 TNF receptor associated factor 5 2 2
MIRT465774 TMOD3 tropomodulin 3 2 2
MIRT467879 SLC22A23 solute carrier family 22 member 23 2 2
MIRT469636 RAD21 RAD21 cohesin complex component 2 6
MIRT472041 NPAT nuclear protein, coactivator of histone transcription 2 2
MIRT476568 GABARAPL1 GABA type A receptor associated protein like 1 2 2
MIRT478586 CTDSPL2 CTD small phosphatase like 2 2 2
MIRT478870 CREBRF CREB3 regulatory factor 2 2
MIRT482202 AHR aryl hydrocarbon receptor 2 2
MIRT484237 IER2 immediate early response 2 2 2
MIRT487480 NRF1 nuclear respiratory factor 1 2 6
MIRT493746 GRAP2 GRB2-related adaptor protein 2 2 2
MIRT496836 ZNF460 zinc finger protein 460 2 2
MIRT497234 APOL2 apolipoprotein L2 2 2
MIRT499424 PLCG2 phospholipase C gamma 2 2 9
MIRT500598 UBN2 ubinuclein 2 2 10
MIRT502859 CHEK2 checkpoint kinase 2 2 6
MIRT507727 CLIC4 chloride intracellular channel 4 2 4
MIRT510509 YOD1 YOD1 deubiquitinase 2 6
MIRT511901 FNBP1L formin binding protein 1 like 2 6
MIRT514393 CLUAP1 clusterin associated protein 1 2 2
MIRT520180 WBP2 WW domain binding protein 2 2 4
MIRT531214 PLA2G4D phospholipase A2 group IVD 2 2
MIRT532846 ZNF699 zinc finger protein 699 2 2
MIRT533461 TRIM71 tripartite motif containing 71 2 2
MIRT539263 ANKRD44 ankyrin repeat domain 44 2 2
MIRT539380 ADSS adenylosuccinate synthase 2 6
MIRT548129 GAS1 growth arrest specific 1 2 2
MIRT550662 ZFP37 ZFP37 zinc finger protein 2 2
MIRT551499 CENPN centromere protein N 2 2
MIRT553778 TAF13 TATA-box binding protein associated factor 13 2 2
MIRT554376 SFPQ splicing factor proline and glutamine rich 2 2
MIRT555821 PCDH11Y protocadherin 11 Y-linked 2 4
MIRT557558 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT557694 GATA6 GATA binding protein 6 2 2
MIRT561383 TWF1 twinfilin actin binding protein 1 2 2
MIRT561414 TSN translin 2 2
MIRT561867 MSH6 mutS homolog 6 2 2
MIRT567383 GTPBP3 GTP binding protein 3, mitochondrial 2 2
MIRT569272 PCDH11X protocadherin 11 X-linked 2 2
MIRT569556 UNC119B unc-119 lipid binding chaperone B 2 2
MIRT569760 RIMBP3C RIMS binding protein 3C 2 5
MIRT573387 GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 2 2
MIRT573456 RPL41 ribosomal protein L41 2 2
MIRT573968 DDX21 DExD-box helicase 21 2 2
MIRT574163 ATG10 autophagy related 10 2 2
MIRT574659 KLHL15 kelch like family member 15 2 2
MIRT574907 Plcg2 phospholipase C, gamma 2 2 6
MIRT607496 HEBP2 heme binding protein 2 2 2
MIRT612840 KCNJ12 potassium voltage-gated channel subfamily J member 12 2 4
MIRT613962 TMEM59 transmembrane protein 59 2 2
MIRT621125 PCNXL2 pecanex homolog 2 2 2
MIRT625216 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT643337 MICA MHC class I polypeptide-related sequence A 2 2
MIRT646342 CLIC6 chloride intracellular channel 6 2 2
MIRT647361 WDR5B WD repeat domain 5B 2 2
MIRT650308 SLC35E2 solute carrier family 35 member E2 2 2
MIRT651372 ZBTB21 zinc finger and BTB domain containing 21 2 2
MIRT655301 PEAR1 platelet endothelial aggregation receptor 1 2 2
MIRT681918 SLC11A2 solute carrier family 11 member 2 2 2
MIRT684165 ALDH1B1 aldehyde dehydrogenase 1 family member B1 2 2
MIRT688053 GLUL glutamate-ammonia ligase 2 2
MIRT690210 C5orf45 MRN complex interacting protein 2 2
MIRT691024 CRTC3 CREB regulated transcription coactivator 3 2 2
MIRT697699 WAC WW domain containing adaptor with coiled-coil 2 2
MIRT698201 TMEM30A transmembrane protein 30A 2 2
MIRT698857 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT702292 LDHA lactate dehydrogenase A 4 2
MIRT703341 GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2 2
MIRT704082 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 2 2
MIRT713729 SUCO SUN domain containing ossification factor 2 2
MIRT719487 RBM27 RNA binding motif protein 27 2 2
MIRT722080 SMC2 structural maintenance of chromosomes 2 2 2
MIRT724102 TMEM199 transmembrane protein 199 2 2
MIRT725124 SYNRG synergin gamma 2 2
MIRT725601 CAPN6 calpain 6 2 2
MIRT737186 RBM3 RNA binding motif (RNP1, RRM) protein 3 4 0
MIRT755379 NOS3 nitric oxide synthase 3 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-383 Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-383 Vorinostat (SAHA) approved 5311 Microarray A549 human non-small cell lung cancer cells 19513533 2009 up-regulated
miR-383 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-383 Doxorubicin approved 31703 Microarray heart 22859947 2012 up-regulated
miR-383 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-383 Tert-butyl hydroperoxide (t-BHP) NULL 6410 Microarray mouse auditory cells 20510889 2010 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-383-5p Vincristine 5978 approved resistant High Lymphoblastic Leukemia tissue
hsa-miR-383-5p Daunorubicin 30323 NSC82151 approved resistant High Lymphoblastic Leukemia tissue
hsa-miR-383-5p Prednisolone 5755 NSC9120 approved resistant High Lymphoblastic Leukemia tissue
hsa-miR-383-5p L-Asparaginase resistant High Lymphoblastic Leukemia tissue
hsa-miR-383-5p Cisplatin 5460033 NSC119875 approved resistant High Germ Cell Tumor cell line (NTERA-2)
hsa-miR-383-5p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (RKO)
hsa-miR-383-5p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HT-29)
hsa-miR-383-5p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (SKOV3)
hsa-miR-383-5p Docetaxel 148124 NSC628503 approved sensitive High Prostate Cancer cell line (PC-3)
hsa-miR-383-5p Cetuximab sensitive High Colon Cancer cell line
hsa-miR-383-5p Paclitaxel 36314 NSC125973 approved sensitive Low Ovarian Cancer cell line (OVCAR3, A2780)
hsa-miR-383-5p Doxorubicin 31703 NSC123127 approved sensitive Low Hepatocellular Carcinoma cell line (BT-474, SKBR3)
hsa-miR-383-5p Cetuximab + Folfox(Fluorouracil + Leucovorin + Oxaliplatin) resistant High Metastatic Colorectal Cancer tissue
hsa-miR-383-5p Gemcitabine 60750 NSC613327 approved sensitive Low Pancreatic Ductal Adenocarcinoma tissue
hsa-miR-383-5p Fluorouracil 3385 NSC19893 approved sensitive Low Gastric Cancer cell line (AGS)
hsa-miR-383-5p Oxaliplatin 6857599 NSC266046 approved resistant Low Hepatocellular Carcinoma cell line (Hep3B, Huh-7)
hsa-miR-383-5p Cisplatin 5460033 NSC119875 approved sensitive Low Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-383-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-383-5p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-383-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-383-5p Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-383-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-383-5p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-383-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-383-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-383-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-383-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-383-5p Cetuximab resistant tissue (colorectal carcinoma)

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