pre-miRNA Information
pre-miRNA hsa-mir-655   
Genomic Coordinates chr14: 101049550 - 101049646
Synonyms MIRN655, hsa-mir-655, MIR655
Description Homo sapiens miR-655 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-655-5p
Sequence 23| AGAGGUUAUCCGUGUUAUGUUC |44
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs766575622 4 dbSNP
rs754023562 5 dbSNP
rs757713353 10 dbSNP
rs369862924 11 dbSNP
rs552601004 12 dbSNP
rs753191773 14 dbSNP
rs569206109 15 dbSNP
rs373094888 18 dbSNP
rs778280798 22 dbSNP
Putative Targets

Gene Information
Gene Symbol CHSY1   
Synonyms CHSY, CSS1, ChSy-1, TPBS
Description chondroitin sulfate synthase 1
Transcript NM_014918   
Expression
Putative miRNA Targets on CHSY1
3'UTR of CHSY1
(miRNA target sites are highlighted)
>CHSY1|NM_014918|3'UTR
   1 TGTCCAGCTTTGCTGGAAAAGACGTTTTTAATTATCTAATTTATTTTTCAAAAATTTTTTGTATGATCAGTTTTTGAAGT
  81 CCGTATACAAGGATATATTTTACAAGTGGTTTTCTTACATAGGACTCCTTTAAGATTGAGCTTTCTGAACAAGAAGGTGA
 161 TCAGTGTTTGCCTTTGAACACATCTTCTTGCTGAACATTATGTAGCAGACCTGCTTAACTTTGACTTGAAATGTACCTGA
 241 TGAACAAAACTTTTTTAAAAAAATGTTTTCTTTTGAGACCCTTTGCTCCAGTCCTATGGCAGAAAACGTGAACATTCCTG
 321 CAAAGTATTATTGTAACAAAACACTGTAACTCTGGTAAATGTTCTGTTGTGATTGTTAACATTCCACAGATTCTACCTTT
 401 TGTGTTTTGTTTTTTTTTTTTACAATTGTTTTAAAGCCATTTCATGTTCCAGTTGTAAGATAAGGAAATGTGATAATAGC
 481 TGTTTCATCATTGTCTTCAGGAGAGCTTTCCAGAGTTGATCATTTCCTCTCATGGTACTCTGCTCAGCATGGCCACGTAG
 561 GTTTTTTGTTTGTTTTGTTTTGTTCTTTTTTTGAGACGGAGTCTCACTCTGTTACCCAGGCTGGAATGCAGTGGCGCAAT
 641 CTTGGCTCACTTTAACCTCCACTTCCCTGGTTCAAGCAATTCCCCTGCCTTTGCCTCCCGAGTAGCTGGGATTACAGGCA
 721 CACACCACCACGCCCAGCTAGTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGCAAGCCCAGCTGGCCACGTAG
 801 GTTTTAAAGCAAGGGGCGTGAAGAAGGCACAGTGAGGTATGTGGCTGTTCTCGTGGTAGTTCATTCGGCCTAAATAGACC
 881 TGGCATTAAATTTCAAGAAGGATTTGGCATTTTCTCTTCTTGACCCTTCTCTTTAAAGGGTAAAATATTAATGTTTAGAA
 961 TGACAAAGATGAATTATTACAATAAATCTGATGTACACAGACTGAAACATACACACATACACCCTAATCAAAACGTTGGG
1041 GAAAAATGTATTTGGTTTTGTTCCTTTCATCCTGTCTGTGTTATGTGGGTGGAGATGGTTTTCATTCTTTCATTACTGTT
1121 TTGTTTTATCCTTTGTATCTGAAATACCTTTAATTTATTTAATATCTGTTGTTCAGAGCTCTGCCATTTCTTGAGTACCT
1201 GTTAGTTAGTATTATTTATGTGTATCGGGAGTGTGTTTAGTCTGTTTTATTTGCAGTAAACCGATCTCCAAAGATTTCCT
1281 TTTGGAAACGCTTTTTCCCCTCCTTAATTTTTATATTCCTTACTGTTTTACTAAATATTAAGTGTTCTTTGACAATTTTG
1361 GTGCTCATGTGTTTTGGGGACAAAAGTGAAATGAATCTGTCATTATACCAGAAAGTTAAATTCTCAGATCAAATGTGCCT
1441 TAATAAATTTGTTTTCATTTAGATTTCAAACAGTGATAGACTTGCCATTTTAATACACGTCATTGGAGGGCTGCGTATTT
1521 GTAAATAGCCTGATGCTCATTTGGAAAAATAAACCAGTGAACAATATTTTTCTATTGTACTTTTCGAACCATTTTGTCTC
1601 ATTATTCCTGTTTTAGCTGAAGAATTGTATTACATTTGGAGAGTAAAAAACTTAAACACGATTCAAAAAAAAAAAAAAAA
1681 AA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cuuguauuGUGCCUAUUGGAGa 5'
                  |||   ||||||| 
Target 5' tcttggctCAC-TTTAACCTCc 3'
640 - 660 141.00 -10.20
2
miRNA  3' cuUGUAUUGU----GCCUAUUGGAGa 5'
            |::||:||    :|  ||||:|: 
Target 5' ttATGTAGCAGACCTGCTTAACTTTg 3'
198 - 223 122.00 -7.20
3
miRNA  3' cuUGUAUUGUGCCUAUUG-GAga 5'
            ||| ||||| | |||| ||  
Target 5' taACAAAACACTG-TAACTCTgg 3'
334 - 355 119.00 -10.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30499380 23 COSMIC
COSN30100273 24 COSMIC
COSN31565190 52 COSMIC
COSN30683273 54 COSMIC
COSN30130310 58 COSMIC
COSN31566434 59 COSMIC
COSN30486178 68 COSMIC
COSN30128759 82 COSMIC
COSN30148648 85 COSMIC
COSN26595948 196 COSMIC
COSN30171153 257 COSMIC
COSN31609638 270 COSMIC
COSN31522454 277 COSMIC
COSN20112487 409 COSMIC
COSN1174130 410 COSMIC
COSN25796378 480 COSMIC
COSN22190341 495 COSMIC
COSN8160576 597 COSMIC
COSN29216991 741 COSMIC
COSN21065309 756 COSMIC
COSN7036658 919 COSMIC
COSN26561434 1289 COSMIC
COSN31602962 1289 COSMIC
COSN23208308 1393 COSMIC
COSN26593965 1410 COSMIC
COSN26636445 1514 COSMIC
COSN31482830 1532 COSMIC
COSN20112484 1585 COSMIC
COSN30540043 1596 COSMIC
rs3784526 796 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs373092959 4 dbSNP
rs141021837 5 dbSNP
rs766298962 6 dbSNP
rs760818756 7 dbSNP
rs746143969 15 dbSNP
rs1330069327 16 dbSNP
rs1290363676 20 dbSNP
rs750585718 21 dbSNP
rs764119538 23 dbSNP
rs763023648 24 dbSNP
rs1439186302 35 dbSNP
rs775401611 36 dbSNP
rs769734489 37 dbSNP
rs1457507366 40 dbSNP
rs779038187 44 dbSNP
rs1356489643 48 dbSNP
rs944587697 49 dbSNP
rs1406481159 53 dbSNP
rs574647716 54 dbSNP
rs1454403085 59 dbSNP
rs1295227529 63 dbSNP
rs890312915 67 dbSNP
rs1214628533 76 dbSNP
rs1196743046 79 dbSNP
rs1310040739 82 dbSNP
rs757711233 83 dbSNP
rs747311107 87 dbSNP
rs1461996523 88 dbSNP
rs1330960760 89 dbSNP
rs932733497 93 dbSNP
rs778375654 95 dbSNP
rs552808006 100 dbSNP
rs988223352 103 dbSNP
rs117081468 109 dbSNP
rs1187154054 114 dbSNP
rs1421803802 116 dbSNP
rs1282067575 125 dbSNP
rs1200507641 126 dbSNP
rs865951535 127 dbSNP
rs1431532328 144 dbSNP
rs1175923161 150 dbSNP
rs946740036 151 dbSNP
rs1470800059 157 dbSNP
rs1343738856 167 dbSNP
rs766196926 179 dbSNP
rs913889210 185 dbSNP
rs1431440350 190 dbSNP
rs988373599 195 dbSNP
rs1364831258 196 dbSNP
rs752874302 197 dbSNP
rs1218137543 201 dbSNP
rs960919122 202 dbSNP
rs1325320477 207 dbSNP
rs1225730821 213 dbSNP
rs1266670583 215 dbSNP
rs1446909416 230 dbSNP
rs765203565 239 dbSNP
rs1217070755 242 dbSNP
rs576457680 256 dbSNP
rs34628229 257 dbSNP
rs558113670 257 dbSNP
rs189273332 263 dbSNP
rs531429027 264 dbSNP
rs1005295839 271 dbSNP
rs1315067565 277 dbSNP
rs887784720 286 dbSNP
rs1161119322 287 dbSNP
rs1348066993 294 dbSNP
rs980871292 296 dbSNP
rs1403789710 307 dbSNP
rs569728441 308 dbSNP
rs368488264 314 dbSNP
rs1415098444 319 dbSNP
rs1407667142 327 dbSNP
rs760403246 337 dbSNP
rs1278615730 347 dbSNP
rs1049212457 349 dbSNP
rs1170907716 350 dbSNP
rs755262623 352 dbSNP
rs1224688532 357 dbSNP
rs772933595 364 dbSNP
rs994584084 366 dbSNP
rs1181148422 367 dbSNP
rs1039574512 371 dbSNP
rs1269738400 378 dbSNP
rs943855940 380 dbSNP
rs962038906 390 dbSNP
rs1014574957 393 dbSNP
rs1232528586 396 dbSNP
rs1470358360 401 dbSNP
rs1187896533 402 dbSNP
rs1441494793 404 dbSNP
rs1178793544 405 dbSNP
rs1253396451 409 dbSNP
rs1423983430 410 dbSNP
rs554865684 410 dbSNP
rs1008832147 411 dbSNP
rs1366842248 412 dbSNP
rs536810585 412 dbSNP
rs935029395 412 dbSNP
rs28737322 413 dbSNP
rs924941482 413 dbSNP
rs969091298 413 dbSNP
rs201939118 414 dbSNP
rs566256771 414 dbSNP
rs1272549721 422 dbSNP
rs34904116 422 dbSNP
rs796689764 422 dbSNP
rs1438681549 423 dbSNP
rs548084719 424 dbSNP
rs960867221 425 dbSNP
rs1443805291 437 dbSNP
rs1228145450 441 dbSNP
rs1184089153 452 dbSNP
rs1327599105 463 dbSNP
rs1286173540 464 dbSNP
rs1447068930 464 dbSNP
rs1166869396 468 dbSNP
rs539319307 477 dbSNP
rs754071268 481 dbSNP
rs1331262221 483 dbSNP
rs1404300849 484 dbSNP
rs1316279529 486 dbSNP
rs1385701394 491 dbSNP
rs996453287 493 dbSNP
rs563337847 500 dbSNP
rs766519228 506 dbSNP
rs1340292914 508 dbSNP
rs1332229318 515 dbSNP
rs904350093 526 dbSNP
rs3784523 528 dbSNP
rs1027640501 536 dbSNP
rs1158408469 539 dbSNP
rs1455436348 541 dbSNP
rs1373193707 549 dbSNP
rs946801677 556 dbSNP
rs772830207 559 dbSNP
rs1008478500 576 dbSNP
rs1469601897 576 dbSNP
rs1408905449 585 dbSNP
rs1472234892 585 dbSNP
rs1366389558 594 dbSNP
rs550191571 596 dbSNP
rs1194662560 597 dbSNP
rs145103094 598 dbSNP
rs1249175245 603 dbSNP
rs3784524 605 dbSNP
rs1281548576 607 dbSNP
rs1323166809 611 dbSNP
rs1223891336 615 dbSNP
rs1463944187 616 dbSNP
rs774187627 626 dbSNP
rs1292406513 635 dbSNP
rs761623559 636 dbSNP
rs980985873 638 dbSNP
rs1204425214 645 dbSNP
rs1262377769 646 dbSNP
rs1448153007 648 dbSNP
rs1355868311 658 dbSNP
rs1282688554 659 dbSNP
rs1196731076 666 dbSNP
rs935249088 667 dbSNP
rs969990859 669 dbSNP
rs903552261 675 dbSNP
rs1177579197 679 dbSNP
rs1431842569 684 dbSNP
rs920756440 685 dbSNP
rs973579587 686 dbSNP
rs961793051 687 dbSNP
rs1301445618 688 dbSNP
rs1345085516 690 dbSNP
rs1405832861 695 dbSNP
rs3784525 698 dbSNP
rs374348631 699 dbSNP
rs1219587061 700 dbSNP
rs1351572803 705 dbSNP
rs1323926059 719 dbSNP
rs939551193 724 dbSNP
rs1008531107 731 dbSNP
rs1417645148 732 dbSNP
rs1181611617 735 dbSNP
rs1455842102 736 dbSNP
rs954359602 746 dbSNP
rs1411155253 747 dbSNP
rs529864405 750 dbSNP
rs996093075 751 dbSNP
rs559100661 753 dbSNP
rs904377170 757 dbSNP
rs184438808 758 dbSNP
rs1425412867 760 dbSNP
rs749384044 765 dbSNP
rs576716148 766 dbSNP
rs1418854552 768 dbSNP
rs1186147489 769 dbSNP
rs1307496674 774 dbSNP
rs564583524 777 dbSNP
rs1249007500 779 dbSNP
rs775543015 780 dbSNP
rs1027877931 785 dbSNP
rs1222742712 787 dbSNP
rs3784526 796 dbSNP
rs116051847 797 dbSNP
rs775287163 803 dbSNP
rs769530999 811 dbSNP
rs1195559480 815 dbSNP
rs1343152849 817 dbSNP
rs193176744 818 dbSNP
rs1385161282 822 dbSNP
rs1445249434 824 dbSNP
rs1226320652 830 dbSNP
rs1008974810 832 dbSNP
rs747404843 837 dbSNP
rs948308537 852 dbSNP
rs188244423 853 dbSNP
rs74040363 866 dbSNP
rs903787963 867 dbSNP
rs1043584900 872 dbSNP
rs1335938589 873 dbSNP
rs572707920 874 dbSNP
rs777980427 885 dbSNP
rs947764528 890 dbSNP
rs1292870386 898 dbSNP
rs1306534110 900 dbSNP
rs1227633642 907 dbSNP
rs1252733539 914 dbSNP
rs1459318949 919 dbSNP
rs894807623 924 dbSNP
rs144560619 926 dbSNP
rs35892031 935 dbSNP
rs1183652721 940 dbSNP
rs539383488 945 dbSNP
rs983652952 947 dbSNP
rs558738859 964 dbSNP
rs1166138620 969 dbSNP
rs1415730390 974 dbSNP
rs1335920392 979 dbSNP
rs987213089 982 dbSNP
rs1192349618 990 dbSNP
rs920848673 992 dbSNP
rs561678409 996 dbSNP
rs974987354 998 dbSNP
rs28754726 1008 dbSNP
rs11433 1010 dbSNP
rs1222060101 1012 dbSNP
rs987983999 1012 dbSNP
rs975082936 1013 dbSNP
rs1483483489 1014 dbSNP
rs956167443 1020 dbSNP
rs1274245665 1021 dbSNP
rs968632889 1034 dbSNP
rs1485553713 1035 dbSNP
rs999317278 1036 dbSNP
rs967853553 1040 dbSNP
rs538198585 1041 dbSNP
rs1279240880 1042 dbSNP
rs748600403 1044 dbSNP
rs1218508544 1047 dbSNP
rs192694836 1050 dbSNP
rs1012107128 1056 dbSNP
rs1289939117 1063 dbSNP
rs894839051 1068 dbSNP
rs779415901 1073 dbSNP
rs186944629 1076 dbSNP
rs1031079061 1080 dbSNP
rs1003594015 1084 dbSNP
rs1467125471 1093 dbSNP
rs755052034 1094 dbSNP
rs1283563371 1095 dbSNP
rs1359166625 1096 dbSNP
rs1221312254 1098 dbSNP
rs1003565820 1104 dbSNP
rs1282758048 1111 dbSNP
rs527768464 1122 dbSNP
rs1045044148 1127 dbSNP
rs1288308146 1129 dbSNP
rs148690433 1130 dbSNP
rs1414349494 1137 dbSNP
rs1427858823 1138 dbSNP
rs1161789868 1140 dbSNP
rs753870351 1143 dbSNP
rs1478854140 1147 dbSNP
rs781338992 1148 dbSNP
rs1407156981 1155 dbSNP
rs1251347924 1162 dbSNP
rs1175770759 1163 dbSNP
rs1160410135 1166 dbSNP
rs1038359656 1172 dbSNP
rs940874764 1177 dbSNP
rs1209542696 1197 dbSNP
rs796168975 1200 dbSNP
rs1439051024 1204 dbSNP
rs908030078 1205 dbSNP
rs575837909 1211 dbSNP
rs987241038 1212 dbSNP
rs1312134341 1215 dbSNP
rs780272635 1226 dbSNP
rs547185820 1227 dbSNP
rs1328295452 1232 dbSNP
rs369417198 1236 dbSNP
rs1453605638 1237 dbSNP
rs1286227506 1242 dbSNP
rs1397355043 1246 dbSNP
rs1379468668 1253 dbSNP
rs1301712731 1257 dbSNP
rs1202139167 1261 dbSNP
rs1470408689 1262 dbSNP
rs1180359083 1263 dbSNP
rs1443470517 1279 dbSNP
rs1163745759 1286 dbSNP
rs114939488 1289 dbSNP
rs144097370 1290 dbSNP
rs978809298 1292 dbSNP
rs1354267294 1293 dbSNP
rs750271337 1294 dbSNP
rs1447986623 1299 dbSNP
rs1333881913 1300 dbSNP
rs1245331888 1302 dbSNP
rs1381296778 1302 dbSNP
rs1284894766 1305 dbSNP
rs370738241 1306 dbSNP
rs1212987558 1308 dbSNP
rs967884674 1328 dbSNP
rs1022067523 1329 dbSNP
rs767211625 1332 dbSNP
rs1458091343 1334 dbSNP
rs545711411 1347 dbSNP
rs1157394247 1348 dbSNP
rs1460848798 1348 dbSNP
rs955900699 1352 dbSNP
rs575963169 1355 dbSNP
rs1474156927 1361 dbSNP
rs761866321 1362 dbSNP
rs1166885908 1363 dbSNP
rs1419801370 1364 dbSNP
rs377533784 1369 dbSNP
rs1003210831 1377 dbSNP
rs1404498222 1379 dbSNP
rs1035464919 1382 dbSNP
rs1452610717 1383 dbSNP
rs1335487548 1395 dbSNP
rs886099798 1397 dbSNP
rs1428738420 1398 dbSNP
rs1003597048 1402 dbSNP
rs1269815851 1404 dbSNP
rs906593799 1405 dbSNP
rs751468217 1409 dbSNP
rs1220210872 1412 dbSNP
rs1047506264 1423 dbSNP
rs1249812399 1424 dbSNP
rs1322584484 1436 dbSNP
rs1200920804 1437 dbSNP
rs1209202401 1445 dbSNP
rs560703197 1464 dbSNP
rs1024059705 1471 dbSNP
rs1012290618 1472 dbSNP
rs899155632 1485 dbSNP
rs1246755774 1498 dbSNP
rs1478621399 1499 dbSNP
rs1321918441 1502 dbSNP
rs1311633009 1509 dbSNP
rs1196268242 1512 dbSNP
rs182238593 1514 dbSNP
rs762584257 1515 dbSNP
rs1405056701 1517 dbSNP
rs775092312 1519 dbSNP
rs1366825966 1529 dbSNP
rs1297703603 1532 dbSNP
rs1341340808 1535 dbSNP
rs1402030459 1536 dbSNP
rs1281654595 1538 dbSNP
rs1436388349 1542 dbSNP
rs1233719996 1554 dbSNP
rs940905950 1564 dbSNP
rs1287447545 1567 dbSNP
rs375130206 1574 dbSNP
rs1348535656 1576 dbSNP
rs1204003821 1577 dbSNP
rs1039237406 1580 dbSNP
rs200663666 1584 dbSNP
rs144425967 1585 dbSNP
rs199694133 1585 dbSNP
rs199976064 1586 dbSNP
rs35004007 1586 dbSNP
rs372763534 1587 dbSNP
rs921659963 1591 dbSNP
rs1267751137 1598 dbSNP
rs1039190925 1600 dbSNP
rs554004717 1607 dbSNP
rs934714611 1626 dbSNP
rs572163628 1627 dbSNP
rs1392034561 1651 dbSNP
rs554027150 1659 dbSNP
rs1290992768 1660 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cuuguauuGUGCCUAUUGGAGa 5'
                  |||   ||||||| 
Target 5' ------cuCAC-UUUAACCUCc 3'
1 - 15
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000254190.3 | 3UTR | CUCACUUUAACCUCCACUUCCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
91 hsa-miR-655-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT080691 KIAA1468 KIAA1468 2 2
MIRT095086 SEC24A SEC24 homolog A, COPII coat complex component 2 4
MIRT122450 SMIM13 small integral membrane protein 13 2 2
MIRT214635 SMAD5 SMAD family member 5 2 4
MIRT268267 CCND1 cyclin D1 2 2
MIRT312418 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT329008 DSTN destrin, actin depolymerizing factor 2 2
MIRT329824 PDCD4 programmed cell death 4 2 4
MIRT389635 LRRC58 leucine rich repeat containing 58 2 6
MIRT443969 FAM198B family with sequence similarity 198 member B 2 2
MIRT444080 C12orf73 chromosome 12 open reading frame 73 2 2
MIRT444886 TMEM196 transmembrane protein 196 2 2
MIRT445506 CRNKL1 crooked neck pre-mRNA splicing factor 1 2 4
MIRT446292 ACSL3 acyl-CoA synthetase long chain family member 3 2 2
MIRT446462 THAP1 THAP domain containing 1 2 2
MIRT446472 THUMPD3 THUMP domain containing 3 2 2
MIRT447413 MED21 mediator complex subunit 21 2 2
MIRT447491 KIAA1715 lunapark, ER junction formation factor 2 2
MIRT448965 CDADC1 cytidine and dCMP deaminase domain containing 1 2 2
MIRT449602 INIP INTS3 and NABP interacting protein 2 2
MIRT449607 PRPF4 pre-mRNA processing factor 4 2 2
MIRT449737 TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 2 2
MIRT451668 KRT8 keratin 8 2 4
MIRT452424 QDPR quinoid dihydropteridine reductase 2 2
MIRT455187 AGTRAP angiotensin II receptor associated protein 2 2
MIRT456059 SLC25A28 solute carrier family 25 member 28 2 2
MIRT456488 SERAC1 serine active site containing 1 2 2
MIRT456631 ARMCX6 armadillo repeat containing, X-linked 6 2 2
MIRT459621 SLC25A33 solute carrier family 25 member 33 2 2
MIRT461162 SLC11A2 solute carrier family 11 member 2 2 4
MIRT461990 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT463149 ZNF385A zinc finger protein 385A 2 4
MIRT463465 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT463801 XPOT exportin for tRNA 2 2
MIRT464010 WDR26 WD repeat domain 26 2 2
MIRT465302 TRIB1 tribbles pseudokinase 1 2 2
MIRT468837 RRM2 ribonucleotide reductase regulatory subunit M2 2 2
MIRT469132 RNF126 ring finger protein 126 2 2
MIRT469244 RHOB ras homolog family member B 2 2
MIRT472414 NCKAP1 NCK associated protein 1 2 2
MIRT472432 NCBP2 nuclear cap binding protein subunit 2 2 2
MIRT472808 MTMR12 myotubularin related protein 12 2 2
MIRT477893 DVL3 dishevelled segment polarity protein 3 2 4
MIRT477963 DPM2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory 2 2
MIRT479258 CHSY1 chondroitin sulfate synthase 1 2 2
MIRT479718 CCNF cyclin F 2 2
MIRT480231 C9orf41 carnosine N-methyltransferase 1 2 2
MIRT482600 ABHD14B abhydrolase domain containing 14B 2 2
MIRT483096 TFPI tissue factor pathway inhibitor 2 2
MIRT484644 TBC1D5 TBC1 domain family member 5 2 4
MIRT488899 CLDND1 claudin domain containing 1 2 2
MIRT491954 VPS52 VPS52, GARP complex subunit 2 2
MIRT496937 LBR lamin B receptor 2 2
MIRT498546 TMEM30B transmembrane protein 30B 2 2
MIRT501778 NRBF2 nuclear receptor binding factor 2 2 6
MIRT516286 DBT dihydrolipoamide branched chain transacylase E2 2 2
MIRT516351 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT516751 ZNF100 zinc finger protein 100 2 2
MIRT517939 ZNF431 zinc finger protein 431 2 4
MIRT518295 ZNF514 zinc finger protein 514 2 4
MIRT518515 CASP10 caspase 10 2 2
MIRT519017 NOA1 nitric oxide associated 1 2 2
MIRT519171 SCO1 SCO1, cytochrome c oxidase assembly protein 2 2
MIRT519470 SPTLC2 serine palmitoyltransferase long chain base subunit 2 2 2
MIRT521029 SLC30A5 solute carrier family 30 member 5 2 2
MIRT521251 SAMD8 sterile alpha motif domain containing 8 2 2
MIRT521682 PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha 2 2
MIRT529386 SKP1 S-phase kinase associated protein 1 2 2
MIRT545507 NAP1L1 nucleosome assembly protein 1 like 1 2 2
MIRT549655 RSL1D1 ribosomal L1 domain containing 1 2 2
MIRT551041 CTSB cathepsin B 2 4
MIRT551441 ZNF490 zinc finger protein 490 2 4
MIRT554778 RHEBP1 RHEB pseudogene 1 2 4
MIRT565793 SEC14L5 SEC14 like lipid binding 5 2 2
MIRT566727 MSL2 MSL complex subunit 2 2 2
MIRT574668 HNRNPDL heterogeneous nuclear ribonucleoprotein D like 2 2
MIRT610128 DENND5B DENN domain containing 5B 2 2
MIRT624919 FBXW2 F-box and WD repeat domain containing 2 2 2
MIRT641830 TRIM71 tripartite motif containing 71 2 2
MIRT662165 IFNAR2 interferon alpha and beta receptor subunit 2 2 2
MIRT667150 NRXN3 neurexin 3 2 2
MIRT689085 ADNP2 ADNP homeobox 2 2 2
MIRT696322 DCAF15 DDB1 and CUL4 associated factor 15 2 2
MIRT699062 SNX4 sorting nexin 4 2 2
MIRT703229 GOLGA1 golgin A1 2 2
MIRT705743 AMD1 adenosylmethionine decarboxylase 1 2 2
MIRT706087 HNRNPU heterogeneous nuclear ribonucleoprotein U 2 2
MIRT709288 MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 2 2
MIRT711457 RNF145 ring finger protein 145 2 2
MIRT714708 PPP3CC protein phosphatase 3 catalytic subunit gamma 2 2
MIRT719871 CYP4F11 cytochrome P450 family 4 subfamily F member 11 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-655 Gefitinib approved 123631 Quantitative real-time PCR lung adenocarcinoma cells 24258346 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-655 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-655 Androstenedione 6128 NSC9563 resistant cell line (MCF-7)
hsa-mir-655 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-655-5p Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-655-5p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-655-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-655-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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